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1. Reorganisation of GP surgeries during the COVID-19 outbreak: analysis of guidelines from 15 countries

Author

Tsopra, Rosy, Frappe, Paul, Streit, Sven, Neves, Ana Luisa, Honkoop, Persijn J., Espinosa-Gonzalez, Ana Belen, Geroğlu, Berk, Jahr, Tobias, Lingner, Heidrun, Nessler, Katarzyna, Pesolillo, Gabriella, Sivertsen, Øyvind Stople, Thulesius, Hans, Zoitanu, Raluca, Burgun, Anita, Kinouani, Shérazade, Sciences de l’information au service de la médecine personnalisée = Information Sciences to support Personalized Medicine [CRC], Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC CHU Lyon (inserm), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Bern, Imperial College London, Federal University of Health Sciences of Porto Alegre = Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Leiden University Medical Center (LUMC), Izmir Institute of Technology (IZTECH), Hannover Medical School [Hannover] (MHH), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Lund University [Lund], Linneaus University, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Biotechnologie et Microbiologie Appliquée (LBMA), Université Bordeaux Segalen - Bordeaux 2-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade do Porto = University of Porto, Universiteit Leiden, İzmir Karşıyaka District Health Directorate [İzmir, Turkey] (IKDHD), Medizinische Hochschule Hannover (MHH), German Center for Lung Research, ASL Teramo [Abruzzo, Italy] (ASLT), Torshovdalen Health Center [Oslo, Norway] (THC), National Federation of Family Medicine Employers in Romania [București, Romania] (FNPMF), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), HAL-SU, Gestionnaire, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École pratique des hautes études (EPHE), CIC Saint Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Nord (Saint Etienne), and TSOPRA, Rosy

Subjects
Medicine (General), Internationality, [SDV]Life Sciences [q-bio], General Practice, Guidelines as Topic, 1110 Nursing, 610 Medicine & health, MESH: Primary Health Care, 1117 Public Health and Health Services, Medicine, General & Internal, R5-920, 360 Social problems & social services, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, General & Internal Medicine, MESH: General Practice, SURVEILLANCE, Humans, MESH: COVID-19, General&#160, General Practitioner, Practitioner, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Science & Technology, MESH: Humans, Primary Health Care, Pandemic, CLINICAL GUIDELINES, MESH: Guidelines as Topic, COVID-19, Primary care, [SDV] Life Sciences [q-bio], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Internationality, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, Clinical Practice Guidelines, Life Sciences & Biomedicine, Research Article
Abstract

Background General practitioners (GPs) play a key role in managing the COVID-19 outbreak. However, they may encounter difficulties adapting their practices to the pandemic. We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the pandemic from 15 countries. Methods A network of GPs collaborated together in a three-step process: (i) identification of key recommendations of GP surgery reorganisation, according to WHO, CDC and health professional resources from health care facilities; (ii) collection of key recommendations included in the guidelines published in 15 countries; (iii) analysis, comparison and synthesis of the results. Results Recommendations for the reorganisation of GP surgeries of four types were identified: (i) reorganisation of GP consultations (cancelation of non-urgent consultations, follow-up via e-consultations), (ii) reorganisation of GP surgeries (area partitioning, visual alerts and signs, strict hygiene measures), (iii) reorganisation of medical examinations by GPs (equipment, hygiene, partial clinical examinations, patient education), (iv) reorganisation of GP staff (equipment, management, meetings, collaboration with the local community). Conclusions We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the COVID-19 outbreak from 15 countries. These guidelines focus principally on clinical care, with less attention paid to staff management, and the area of epidemiological surveillance and research is largely neglected. The differences of guidelines between countries and the difficulty to apply them in routine care, highlight the need of advanced research in primary care. Thereby, primary care would be able to provide recommendations adapted to the real-world settings and with stronger evidence, which is especially necessary during pandemics. Supplementary Information The online version contains supplementary material available at 10.1186/s12875-021-01413-z.

Published
2021

2. Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

Author

Dan M. Roden, Marylyn D. Ritchie, Jae-Gook Shin, Braxton D. Mitchell, Teri E. Klein, Gian Franco Gensini, Jurriën M. ten Berg, Pierre Fontana, Lene Holmvang, Israel Fernandez-Cadenas, Willibald Hochholzer, Stefan Winter, Tabassome Simon, Ruth E. Pakyz, Paul A. Gurbel, Richard B. Horenstein, Ming-Shien Wen, Tobias Geisler, John H. Cleator, Marco Valgimigli, Ho-Sook Kim, Jean-Sébastien Hulot, Jolanta M. Siller-Matula, Dietmar Trenk, Gianluca Campo, Michiaki Kubo, Elke Schaeffeler, Nadia Paarup Dridi, Ming Ta Michael Lee, Li Gong, Joshua P. Lewis, Jean-Pierre Déry, Rossella Marcucci, Kiyuk Chang, Meinrad Gawaz, Kevin P. Bliden, Alan R. Shuldiner, Daniel Aradi, Thomas O. Bergmeijer, Betti Giusti, Russ B. Altman, Dimitrios Alexopoulos, Matthias Schwab, Ryan Whaley, Jean-Luc Reny, Joan Montaner, Eun Young Kim, Reny, Jean-Luc, Fontana, Pierre, Centre de Ressources Biologiques HUEP-UPMC (CRB HUEP-UPMC), UMS omique (OMIQUE), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Oncology, Male, Candidate gene, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Internationality, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Genome-wide association study, 030204 cardiovascular system & hematology, Cardiovascular Medicine, MESH: Risk Assessment, MESH: Receptors, Purinergic P2Y12, 0302 clinical medicine, P2Y12, MESH: Molecular Targeted Therapy, Receptors, Medicine, 030212 general & internal medicine, Molecular Targeted Therapy, MESH: Treatment Outcome, MESH: Genetic Association Studies, Cardiology, Cardiovascular Medicine, MESH: Aged, ddc:616, Acute Coronary Syndrome/diagnosis/drug therapy/mortality, MESH: Middle Aged, Purinergic P2Y12/drug effects/genetics, Middle Aged, Clopidogrel, Prognosis, Receptors, Purinergic P2Y12, 3. Good health, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Survival Rate, Treatment Outcome, Female, Cardiology and Cardiovascular Medicine, medicine.drug, circulatory and respiratory physiology, Acute coronary syndrome, medicine.medical_specialty, MESH: Survival Rate, Cardiology, MESH: Pharmacogenetics, CYP2C19, Clopidogrel/therapeutic use, Risk Assessment, MESH: Prognosis, Article, NO, 03 medical and health sciences, Internal medicine, Humans, cardiovascular diseases, Acute Coronary Syndrome, Genetic Association Studies, Aged, MESH: Humans, business.industry, MESH: Clopidogrel, medicine.disease, Genome-wide association approach, candidate gene approaches, clopidogrel, efficacy, pharmacodynamic, clinical end points, International Clopidogrel Pharmacogenomics Consortium (ICPC), Cardiovascular Medicine, MESH: Acute Coronary Syndrome, MESH: Male, Pharmacogenetics, Pharmacogenomics, MESH: Genome-Wide Association Study, ddc:618.97, MESH: Internationality, business, MESH: Female, Molecular Targeted Therapy/methods, Genome-Wide Association Study
Abstract

RATIONALE: The P2Y(12) receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention or ischemic stroke. Platelet inhibition by clopidogrel shows wide inter-patient variability and high on-treatment platelet reactivity is a risk factor for atherothrombotic events, particularly in high-risk populations. CYP2C19 polymorphism plays an important role in this variability, but heritability estimates suggest that additional genetic variants remain unidentified. The aim of the International Clopidogrel Pharmacogenomics Consortium (ICPC) is to identify genetic determinants of clopidogrel pharmacodynamics and clinical response. STUDY DESIGN: Based on the data published on www.clinicaltrials.gov, clopidogrel intervention studies containing genetic and platelet function data were identified for participation. Lead investigators were invited to share DNA samples, platelet function test results, patient characteristics and cardiovascular outcomes, to perform candidate gene and genome-wide association studies. RESULTS: In total, 17 study sites from 13 countries participate in the ICPC, contributing individual patient data from 8,829 patients. Available adenosine diphosphate (ADP) stimulated platelet function tests included Vasodilator-Stimulated Phosphoprotein (VASP) assay, Light Transmittance Aggregometry (LTA) and the VerifyNow P2Y(12) assay. A proof of principle analysis based on genotype data provided by each group showed a strong and consistent association between CYP2C19*2 and platelet reactivity (p-value = 5.1×10(−40)). CONCLUSION: The ICPC aims to identify new loci influencing clopidogrel efficacy by using state-of-the-art genetic techniques in a large cohort of clopidogrel-treated patients in order to better understand the genetic basis of on-treatment response variability.

Published
2017

3. Diagnosis and management of Silver-Russell syndrome: first international consensus statement

Author

Frédéric Brioude, I. Karen Temple, Jet Bliek, Adda Grimberg, Thomas Eggermann, Gudrun E. Moore, Agnès Linglart, Klaus Mohnike, Zeynep Tümer, Edith Said, Ana Pinheiro Machado Canton, Renuka P Dias, Oluwakemi Lokulo-Sodipe, Madeleine D. Harbison, Meropi Toumba, Gerhard Binder, Béatrice Dubern, Anita C. S. Hokken-Koelega, Jennifer Salem, Deborah J G Mackay, Susan M. O’Connell, Miriam Elbracht, Irène Netchine, Justin H Davies, David Monk, Silvia Russo, Emma Wakeling, Mohamad Maghnie, Isabelle Oliver Petit, Krystyna H. Chrzanowska, Eloise Giabicani, Philip Murray, Masayo Kagami, Alexander A. L. Jorge, Tsutomu Ogata, Karen Grønskov, Pediatrics, North West london hospitals NHS Trust, Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), MAGIC Foundation, Department of Clinical Genetics, University of Amsterdam [Amsterdam] (UvA), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU), Clinical genetic clinic, Copenhagen University Hospital, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Service d'endocrinologie pédiatrique [CHU Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Fetal Growth and Developmental Group, University College of London [London] (UCL), Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Department of Pediatrics and Medical Genetics, St. Luke's Hospital, Service de néphrologie et pédiatrie générale [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Human Genetics and Genomic Medicine group, Faculty of Medicine, Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP], and Human Genetics

Subjects
0301 basic medicine, medicine.medical_specialty, Pediatrics, Internationality, Endocrinology, Diabetes and Metabolism, Gonadotropin-Releasing Hormone/therapeutic use, Human Growth Hormone/therapeutic use, MESH: Disease Management, law.invention, Gonadotropin-Releasing Hormone, 03 medical and health sciences, Endocrinology, Randomized controlled trial, law, Internal medicine, MESH: Gonadotropin-Releasing Hormone, medicine, MESH: Human Growth Hormone, Humans, Silver-Russell Syndrome/diagnosis, Motor skill, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, Human Growth Hormone, business.industry, Adrenarche, Disease Management, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, 3. Good health, Diabetes and Metabolism, Growth hormone treatment, Natural history, Silver-Russell Syndrome, 030104 developmental biology, MESH: Silver-Russell Syndrome, Speech delay, MESH: Internationality, Small for gestational age, medicine.symptom, business, Psychosocial
Abstract

International audience; This Consensus Statement summarizes recommendations for clinical diagnosis, investigation and management of patients with Silver-Russell syndrome (SRS), an imprinting disorder that causes prenatal and postnatal growth retardation. Considerable overlap exists between the care of individuals born small for gestational age and those with SRS. However, many specific management issues exist and evidence from controlled trials remains limited. SRS is primarily a clinical diagnosis; however, molecular testing enables confirmation of the clinical diagnosis and defines the subtype. A 'normal' result from a molecular test does not exclude the diagnosis of SRS. The management of children with SRS requires an experienced, multidisciplinary approach. Specific issues include growth failure, severe feeding difficulties, gastrointestinal problems, hypoglycaemia, body asymmetry, scoliosis, motor and speech delay and psychosocial challenges. An early emphasis on adequate nutritional status is important, with awareness that rapid postnatal weight gain might lead to subsequent increased risk of metabolic disorders. The benefits of treating patients with SRS with growth hormone include improved body composition, motor development and appetite, reduced risk of hypoglycaemia and increased height. Clinicians should be aware of possible premature adrenarche, fairly early and rapid central puberty and insulin resistance. Treatment with gonadotropin-releasing hormone analogues can delay progression of central puberty and preserve adult height potential. Long-term follow up is essential to determine the natural history and optimal management in adulthood.

Published
2017

4. Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017)

Author

Adams, M, Lefkowitz, E, King, A, Harrach, B, Harrison, R, Knowles, N, Kropinski, A, Krupovic, M, Kuhn, J, Mushegian, A, Nibert, M, Sabanadzovic, S, Sanfaçon, H, Siddell, S, Simmonds, P, Varsani, A, Zerbini, F, Gorbalenya, A, Davison, A, International Committee on Taxonomy of Viruses (ICTV), University of Alabama at Birmingham [ Birmingham] (UAB), Institute for Animal Health, the Pirbright Institute, Hungarian Academy of Sciences (MTA), United States Department of Agriculture (USDA), University of Guelph, Biologie Moléculaire du Gène chez les Extrêmophiles (BMGE), Institut Pasteur [Paris], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), National Science Foundation [Arlington] (NSF), Harvard Medical School [Boston] (HMS), Mississippi State University [Mississippi], Agriculture and Agri-Food [Ottawa] (AAFC), University of Bristol [Bristol], University of Oxford [Oxford], Arizona State University [Tempe] (ASU), Universidade Federal de Vicosa (UFV), Leiden University Medical Center (LUMC), Lomonosov Moscow State University (MSU), University of Glasgow, A.R.M. is a Program Director at the U.S. National Science Foundation (NSF), his work on this project was supported in part by the NSF Independent Research and Development program, but the statements and opinions expressed herein are made in the personal capacity and do not constitute the endorsement by NSF or the government of the United States. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services or of the institutions and companies affiliated with the authors. This work was supported in part through Battelle Memorial Institute’s prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. A subcontractor to Battelle Memorial Institute who performed this work is: J.H.K., an employee of Tunnell Government Services, Inc. N.J.K. is partially supported by core funding provided by the Biotechnology and Biological Sciences Research Council, UK. B.H. is partially supported by National Research, Development and Innovation Office—NKFIH, K100163. A.E.G. is partially supported by EU project EVAg 653316 and the Leids Universiteits Fonds. A.J.D. is supported by the Medical Research Council (MC_UU_12014/3). S.S. acknowledges partial support from Mississippi Agricultural and Forestry Experiment Station (MAFES)., The Pirbright Institute, Biotechnology and Biological Sciences Research Council (BBSRC), Institut Pasteur [Paris] (IP), Agriculture and Agri-Food (AAFC), University of Oxford, Universidade Federal de Viçosa = Federal University of Viçosa (UFV), and Universiteit Leiden

Subjects
0301 basic medicine, MESH: Terminology as Topic, Internationality, viruses, [SDV]Life Sciences [q-bio], education, 030106 microbiology, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, MESH: Viruses, 03 medical and health sciences, Specific proposal, Terminology as Topic, Virology, Humans, skin and connective tissue diseases, health care economics and organizations, Suffix, Executive Committee, MESH: Humans, Specific Proposal, General Medicine, International Committee, 3. Good health, 030104 developmental biology, Viruses, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Internationality, sense organs, International Code
Abstract

International audience; This article lists the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in March 2017.

Published
2017
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5. Medical informatics and bioinformatics: A bibliometric study

Author

Dominic Clark, J. van der Lei, Ioannis G. Tollis, J.L. Coatrieux, Francesco Beltrame, Luciano Milanesi, Graham Cameron, E.D.H. Barbolla, J.Y. Bansard, Fernando Martin-Sanchez, E.M. van Mulligen, Dietrich Rebholz-Schuhmann, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Department of medical informatics, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Bioengineering (DIST), Universita degli studi di Genova, Universite Polytechnica de Madrid, Universidad Politécnica de Madrid (UPM), Medical Bioinformatics department, Institute of Health 'Carlos III', Institute for Biomedical Technologies (ITB), Consiglio Nazionale delle Ricerche [Roma] (CNR), Foundation for Research and Technology, SYMBIOmatics Project A Specific Support Action supported by the European Commission. This project included international expert survey in addition to statistical analysis of the literature, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Genova = University of Genoa (UniGe), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Senhadji, Lotfi, and Medical Informatics

Subjects
Internationality, medicine, Computer science, Bioinformatics, Health informatics, correspondence analysis, MESH: Natural Language Processing, Health Administration Informatics, [SHS.STAT] Humanities and Social Sciences/Methods and statistics, informatics, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], Principal Component Analysis, PCA, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SHS.STAT]Humanities and Social Sciences/Methods and statistics, Translational bioinformatics, biology, 05 social sciences, MESH: Vocabulary, Controlled, bioinformatics, General Medicine, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Computer Science Applications, Vocabulary, Controlled, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Periodicals as Topic, 050904 information & library sciences, MESH: Computational Biology, Biotechnology, MEDLINE, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, Bibliometrics, 050905 science studies, [SHS.INFO] Humanities and Social Sciences/Library and information sciences, Article, bioinformatics (BI), Controlled vocabulary, MESH: MEDLINE, Translational research informatics, Electrical and Electronic Engineering, Natural Language Processing, [SDV.IB] Life Sciences [q-bio]/Bioengineering, business.industry, MCA, Engineering informatics, Computational Biology, Databases, Bibliographic, Data science, MESH: Medical Informatics, MESH: Databases, Bibliographic, Informatics, MESH: Internationality, bibliometrics, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], 0509 other social sciences, business, Medical Informatics, MESH: Periodicals as Topic
Abstract

International audience; This paper reports on an analysis of the bioinformatics and medical informatics literature with the objective to identify upcoming trends that are shared among both research fields to derive benefits from potential collaborative initiatives for their future. Our results present the main characteristics of the two fields and show that these domains are still relatively separated.

Published
2007

6. Familial occurrence and heritable connective tissue disorders in cervical artery dissection

Author

Ayse Altintas, Didier Leys, Paolo Costa, Ralf W. Baumgartner, Christian Stapf, Stefano Paolucci, Valeria Caso, Anna Bersano, Yves Samson, Yannick Béjot, Barbara Goeggel Simonetti, Sabrina Schilling, Emmanuel Touzé, Caspar Grond-Ginsbach, Philippe Lyrer, Urs Fischer, C. Lamy, Tobias Brandt, Antti J. Metso, Stefan T. Engelter, Juan Jose Martin, Jean Dallongeville, Hugues Chabriat, Michael Frank, Manja Kloss, Elisabeth Tournier-Lasserve, Vincent Thijs, Maria Sessa, Ingrid Hausser, Christoph Lichy, Marcel Arnold, Dominique P. Germain, Stéphanie Debette, Alessandro Pezzini, Simon Jung, Turgut Tatlisumak, Marie-Germaine Bousser, Armin J. Grau, Tiina M. Metso, Dominique Hervé, Hakan Sarikaya, INSERM U897, University of Bordeaux, France, Department for Internal Medicine, Staedtische Kliniken Moenchengladbach, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Universität Heidelberg [Heidelberg], Fondazione Santa Lucia [IRCCS], Clinical and Behavioral Neurology [IRCCS Santa Lucia], Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Laboratoire de physique des interfaces et des couches minces [Palaiseau] (LPICM), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), Institute for Infectiology (IMED), Friedrich-Loeffler-Institut (FLI), Centre d'Etudes Supérieures de Civilisation médiévale (CESCM), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Écophysiologie des Plantes sous Stress environnementaux (LEPSE), Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Deparment of Neurology (LARIBOISIERE - Neurologie), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7), AP-HP Hôpital Raymond Poincaré [Garches], GEOMAR - Helmholtz Centre for Ocean Research [Kiel] (GEOMAR), Université Paris Diderot - Paris 7 (UPD7), U 744, Laboratoire d’Epidémiologie et de Santé Publique, Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (Inserm)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Universität Heidelberg [Heidelberg] = Heidelberg University, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Hôpital Raymond Poincaré [AP-HP], Helmholtz Centre for Ocean Research [Kiel] (GEOMAR), Université Lille Nord de France (COMUE)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (Inserm), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers, Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), DAM Île-de-France ( DAM/DIF ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière ( NEMESIS-CRICM ), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière ( CRICM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Laboratoire de physique des interfaces et des couches minces [Palaiseau] ( LPICM ), École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Institute for Infectiology ( IMED ), Friedrich-Loeffler-Institut ( FLI ), Centre d'Etudes Supérieures de Civilisation médiévale ( CESCM ), Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ), Écophysiologie des Plantes sous Stress environnementaux ( LEPSE ), Institut National de la Recherche Agronomique ( INRA ) -Centre international d'études supérieures en sciences agronomiques ( Montpellier SupAgro ) -Institut national d’études supérieures agronomiques de Montpellier ( Montpellier SupAgro ), Deparment of Neurology ( LARIBOISIERE - Neurologie ), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ), GEOMAR - Helmholtz Centre for Ocean Research [Kiel] ( GEOMAR ), Université Paris Diderot - Paris 7 ( UPD7 ), Université Lille Nord de France-Institut National de la Santé et de la Recherche Médicale ( Inserm ) -Institut Pasteur de Lille, Centre européen de recherche et d'enseignement de géosciences de l'environnement ( CEREGE ), and Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Collège de France ( CdF ) -Institut National de la Recherche Agronomique ( INRA ) -Institut national des sciences de l'Univers ( INSU - CNRS )

Subjects
Marfan syndrome, Male, Pathology, Internationality, Cervical Artery, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Vertebral artery dissection, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 030204 cardiovascular system & hematology, [ INFO.INFO-CV ] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Cohort Studies, 0302 clinical medicine, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, MESH : Female, 030212 general & internal medicine, Family history, Connective Tissue Diseases, MESH: Cohort Studies, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Vertebral Artery Dissection, MESH: Middle Aged, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, MESH : Adult, Middle Aged, 3. Good health, Dissection, medicine.anatomical_structure, Osteogenesis imperfecta, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], MESH : Connective Tissue Diseases, Female, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Cohort study, Adult, medicine.medical_specialty, MESH : Male, MESH : Cohort Studies, Connective tissue, MESH: Vertebral Artery Dissection, Dissection (medical), Article, 03 medical and health sciences, MESH : Internationality, Internal medicine, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, MESH : Middle Aged, MESH: Connective Tissue Diseases, MESH: Humans, MESH : Vertebral Artery Dissection, business.industry, MESH : Humans, Correction, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], MESH: Adult, medicine.disease, MESH: Male, Surgery, Ehlers–Danlos syndrome, MESH: Internationality, Neurology (clinical), business, MESH: Female, 030217 neurology & neurosurgery
Abstract

Erratum in: Familial occurrence and heritable connective tissue disorders in cervical artery dissection. [Neurology. 2016]; International audience; In a large series of patients with cervical artery dissection (CeAD), a major cause of ischemic stroke in young and middle-aged adults, we aimed to examine frequencies and correlates of family history of CeAD and of inherited connective tissue disorders. We combined data from 2 large international multicenter cohorts of consecutive patients with CeAD in 23 neurologic departments participating in the CADISP-plus consortium, following a standardized protocol. Frequency of reported family history of CeAD and of inherited connective tissue disorders was assessed. Putative risk factors, baseline features, and 3-month outcome were compared between groups. Among 1,934 consecutive patients with CeAD, 20 patients (1.0%, 95% confidence interval: 0.6%-1.5%) from 17 families (0.9%, 0.5%-1.3%) had a family history of CeAD. Family history of CeAD was significantly more frequent in patients with carotid location of the dissection and elevated cholesterol levels. Two patients without a family history of CeAD had vascular Ehlers-Danlos syndrome with a mutation in COL3A1. This diagnosis was suspected in 2 additional patients, but COL3A1 sequencing was negative. Two patients were diagnosed with classic and hypermobile Ehlers-Danlos syndrome, one patient with Marfan syndrome, and one with osteogenesis imperfecta, based on clinical criteria only. In this largest series of patients with CeAD to date, family history of symptomatic CeAD was rare and inherited connective tissue disorders seemed exceptional. This finding supports the notion that CeAD is a multifactorial disease in the vast majority of cases.

Published
2014

7. Regional differences in heart failure with preserved ejection fraction trials: when nephrology meets cardiology but east does not meet west

Author

Faiez Zannad, Patrick Rossignol, Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Service de Cardiologie [CHRU Nancy], and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)

Subjects
Nephrology, Male, Internationality, MESH: Geography, MESH: Rosuvastatin Calcium, MESH: Sulfonamides, Tetrazoles, 030204 cardiovascular system & hematology, Spironolactone, MESH: Stroke Volume, chemistry.chemical_compound, 0302 clinical medicine, 030212 general & internal medicine, Rosuvastatin Calcium, kidney function, ComputingMilieux_MISCELLANEOUS, Mineralocorticoid Receptor Antagonists, Sulfonamides, Ejection fraction, clinical trials as topic, Geography, 3. Good health, MESH: Patients, MESH: Spironolactone, Cardiology, ventricular function, mineralocorticoids, Female, Cardiology and Cardiovascular Medicine, MESH: Biphenyl Compounds, Cardiac function curve, medicine.medical_specialty, Patients, MESH: Mineralocorticoid Receptor Antagonists, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, left, Physiology (medical), Internal medicine, Post-hoc analysis, medicine, Humans, Heart Failure, aldosterone, MESH: Humans, business.industry, MESH: Tetrazoles, Biphenyl Compounds, Editorials, Stroke Volume, Irbesartan, medicine.disease, MESH: Male, Fluorobenzenes, MESH: Fluorobenzenes, Blood pressure, Pyrimidines, chemistry, MESH: Pyrimidines, Heart failure, MESH: Heart Failure, MESH: Internationality, Benzimidazoles, MESH: Benzimidazoles, business, Heart failure with preserved ejection fraction, MESH: Female
Abstract

In heart failure (HF) with reduced ejection fraction (HF-REF), renin-angiotensin-aldosterone system (RAAS) inhibitors are the Level 1A evidence-based cornerstones of pharmacological treatment. As a result of trial-based progress in medical therapy in the last 2 decades, mortality associated with HF-REF has declined almost 3-fold. In sharp contrast, HF with preserved ejection fraction (HF-PEF) is still lacking evidence-based therapies.1,2 Indeed, the 3 major outcome trials performed in HF-PEF with RAAS inhibitors did not meet their primary end points.3–5 A post hoc analysis of the latest trial, TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist), identified an unusually large difference (≈4-fold) in the placebo group primary event rate of patients randomized from Russia and Georgia (Russia/Georgia) compared with those enrolled from the United States, Argentina, Brazil, and Canada (ie, the Americas).5 Articles see p 34 and p 43 In an effort to better understand this regional heterogeneity, in this issue of Circulation , Pfeffer et al6 performed a comprehensive assessment of clinically relevant variables that may have led to such striking regional discrepancies in terms of patient response to spironolactone. Beyond the inherent limitations of any post hoc analysis, the present data provide major insights into the TOPCAT results that may help change practice in HF-PEF, given the lack of other available therapy in this syndrome. Within each region, the randomized treatment groups were well balanced, whereas between these regions, for almost every variable, baseline characteristics were distinctly different. Over and above the differences in baseline features, the magnitude of changes in blood pressure, kidney function, and potassium kinetics in patients receiving spironolactone was strikingly different across the different geographical areas, being strikingly less pronounced in patients from Russia/Georgia. In the Americas, these changes were more in line with that …

Published
2014

8. Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: Results from a prospective multinational study

Author

Najia Hajjaj-Hassouni, Hassane Awada, M.A.F.J. van de Laar, Maxime Dougados, Claire Bombardier, David T. Felson, Nicholas Bellamy, M. Hochberg, D. van der Heijde, Emilio Martín-Mola, Florence Tubach, Marco Matucci-Cerinic, Philippe Ravaud, Isabelle Logeart, Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Investigation Clinique - Epidémiologie Clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-PRES Sorbonne Paris Cité-Institut National de la Santé et de la Recherche Médicale (INSERM), Rheumatology Department, Universidad Autónoma de Madrid (UAM)-Hospital Universitario La Paz, Université Saint-Joseph de Beyrouth (USJ)-Hotel-Dieu de France Hospital, Centre of National Research on Disability and Rehabilitation Medicine (CONROD), University of Queensland [Brisbane]-Royal Brisbane and Women's Hospital, Institute for Work and Health (IWH), University of Toronto-St. Michael's Hospital-Institute of Medical Sciences, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine (BUSM), Boston University [Boston] (BU)-Boston University [Boston] (BU)-Arthritis Center, Rheumatology and Physical Rehabilitaion Department, Université Mohammed V de Rabat [Agdal] (UM5)-El Ayachi Hospital, Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine, University of Maryland System-University of Maryland System, Pfizer France, Pfizer, Departments of Medicine, Biomedicine & Rheumatology, Università degli Studi di Firenze = University of Florence (UniFI)-Division of Rheumatology AOUC - Denothe Centre, Department of Rheumatology, Arthritis Centre Twente-University of Twente and Medisch Spectrum Twente, University Hospital Maastricht, Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Gillet, Catherine, Faculty of Behavioural, Management and Social Sciences, Psychology, Health & Technology, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-PRES Sorbonne Paris Cité-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Autonoma de Madrid (UAM)-Hospital Universitario La Paz, University of Mohammed V-El Ayachi Hospital, Pfizer Ltd France, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)-Division of Rheumatology AOUC - Denothe Centre, Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques, Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris] - PRES Sorbonne Paris Cité - Institut National de la Santé et de la Recherche Médicale (INSERM) - AP-HP, Universidad Autonoma de Madrid (UAM) - Hospital Universitario La Paz, Université Saint-Joseph de Beyrouth (USJ) - Hotel-Dieu de France Hospital, University of Queensland [Brisbane] - Royal Brisbane and Women's Hospital, University of Toronto - St. Michael's Hospital - Institute of Medical Sciences, Boston University School of Medicine - Arthritis Center, University of Mohammed V - El Ayachi Hospital, Pfizer SAS, Division of Rheumatology AOUC - Denothe Centre - University of Florence, Arthritis Centre Twente - University of Twente and Medisch Spectrum Twente, and Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP]

Subjects
Male, rheumatoid arthritis, Percentile, Internationality, MESH : Aged, MESH : Prospective Studies, MESH : Spondylitis, Ankylosing, MESH : Rheumatic Diseases, Osteoarthritis, Severity of Illness Index, Osteoarthritis, Hip, MESH: Rheumatic Diseases, Arthritis, Rheumatoid, Cohort Studies, Disability Evaluation, 0302 clinical medicine, MESH : Back Pain, reflect, Back pain, MESH: Osteoarthritis, Knee, MESH : Female, 030212 general & internal medicine, Prospective Studies, MESH: Cohort Studies, MESH: Treatment Outcome, MESH: Aged, MESH: Arthritis, Rheumatoid, IR-83841, MESH: Middle Aged, MESH: Disability Evaluation, MESH : Adult, Middle Aged, Osteoarthritis, Knee, MESH: Spondylitis, Ankylosing, 3. Good health, Treatment Outcome, Patient Satisfaction, Rheumatoid arthritis, MESH : Severity of Illness Index, Female, medicine.symptom, MESH : Osteoarthritis, Hip, Chronic Pain, Cohort study, Adult, medicine.medical_specialty, MESH : Patient Satisfaction, MESH : Male, MESH : Chronic Pain, MESH : Cohort Studies, MESH : Disability Evaluation, MESH : Treatment Outcome, 03 medical and health sciences, MESH : Internationality, Rheumatology, Rheumatic Diseases, MESH: Severity of Illness Index, ankylosing spondylitis, medicine, Humans, MESH : Middle Aged, Spondylitis, Ankylosing, METIS-291293, MESH : Osteoarthritis, Knee, Aged, 030203 arthritis & rheumatology, Ankylosing spondylitis, MESH: Humans, business.industry, MESH : Humans, MESH: Adult, medicine.disease, PASS, Confidence interval, MESH: Male, MESH: Patient Satisfaction, MESH: Prospective Studies, MICC, Back Pain, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH : Arthritis, Rheumatoid, MESH: Back Pain, Physical therapy, MESH: Internationality, MESH: Chronic Pain, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Osteoarthritis, Hip, business, MESH: Female, Hand osteoarthritis
Abstract

International audience; OBJECTIVE: To estimate the minimum clinically important improvement (MCII) and patient acceptable symptom state (PASS) values for 4 generic outcomes in 5 rheumatic diseases and 7 countries. METHODS: We conducted a multinational (Australia, France, Italy, Lebanon, Morocco, Spain, and The Netherlands) 4-week cohort study involving 1,532 patients who were prescribed nonsteroidal antiinflammatory drugs for ankylosing spondylitis, chronic back pain, hand osteoarthritis, hip and/or knee osteoarthritis, or rheumatoid arthritis. The MCII and PASS values were estimated with the 75th percentile approach for 4 generic outcomes: pain, patient global assessment, functional disability, and physician global assessment, all normalized to a 0-100 score. RESULTS: For the whole sample, the estimated MCII values for absolute change at 4 weeks were -17 (95% confidence interval [95% CI] -18, -15) for pain; -15 (95% CI -16, -14) for patient global assessment; -12 (95% CI -13, -11) for functional disability assessment; and -14 (95% CI -15, -14) for physician global assessment. For the whole sample, the estimated PASS values were 42 (95% CI 40, 44) for pain; 43 (95% CI 41, 45) for patient global assessment; 43 (95% CI 41, 44) for functional disability assessment; and 39 (95% CI 37, 40) for physician global assessment. Estimates were consistent across diseases and countries (for subgroups ≥20 patients). CONCLUSION: This work allows for promoting the use of values of MCII (15 of 100 for absolute improvement, 20% for relative improvement) and PASS (40 of 100) in reporting the results of trials of any of the 5 involved rheumatic diseases with pain, patient global assessment, physical function, or physician global assessment used as outcome criteria.

Published
2012

9. International recommendations for glucose control in adult non diabetic critically ill patients

Author

Ichai, Carole, Preiser, Jean-Charles, Société Française d'Anesthésie-Réanimation, Société de Réanimation de langue Française, Annane, D, Bouglé, A, Chioléro, R, Damoisel, C, Devos, P, Gunst, Jan, Halimi, S, Jacqueminet, S, Kalfon, P, Lacherade, JC, Laudenbach, V, Leverve, X, Losser, MR, Ouattara, A, Payen de la Garanderie, D, Seematter, G, Tappy, L, Van den Berghe, Greet, Vanhorebeek, Ilse, Wion-Barbot, N, Leone, M, Veber, B, Cariou, A, Barnoud, D, Service de réanimation médicochirurgicale, Centre Hospitalier Universitaire de Nice (CHU Nice), Department of General Intensive Care, Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), The authors thank the SFAR and SRLF for supporting this study., Société Française d'Anesthésie-Réanimation (SFAR), Société de Réanimation de langue Française (SRLF), Experts group, and Hamant, Sarah

Subjects
Blood Glucose, Internationality, 030204 cardiovascular system & hematology, Blood Glucose -- drug effects -- metabolism, Critical Care and Intensive Care Medicine, 0302 clinical medicine, Insulin, Insulin -- pharmacology -- therapeutic use, 030212 general & internal medicine, KUL-METH-Criticalillness, Critical Care -- methods -- standards, Age Factors, Sciences bio-médicales et agricoles, MESH: Health Planning Guidelines, 3. Good health, MESH: Glucose, Glycemic index, Scale (social sciences), MESH: Critical Illness, Adult, medicine.medical_specialty, Critical Care, Health Planning Guidelines, Critical Illness, MEDLINE, Blood sugar, MESH: Insulin, Hypoglycemia, 03 medical and health sciences, MESH: Critical Care, Diabetes mellitus, Intervention (counseling), [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Intensive care medicine, Glycemic, MESH: Age Factors, MESH: Humans, business.industry, Research, Critical Illness -- epidemiology -- therapy, MESH: Adult, Glucose -- metabolism, medicine.disease, Glucose, Glycemic Index, Glycemic Index -- drug effects -- physiology, MESH: Internationality, MESH: Blood Glucose, MESH: Glycemic Index, business
Abstract

The purpose of this research is to provide recommendations for the management of glycemic control in critically ill patients., Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published, Pour la Société Française d'Anesthésie-Réanimation (SFAR); Société de Réanimation de langue Française (SRLF) and the Experts group

Published
2010

10. A genome-wide linkage and association scan reveals novel loci for autism

Author

Zak Kohane, Jeremy Goldberg, Carine Mantoulan, Shaun Purcell, Jessica Brian, Magdalena Laskawiec, Christopher A. Walsh, Irma Moilanen, Ridha Joober, Peter Szatmari, Olena Korvatska, Kerim Munir, James F. Gusella, Rudolph E. Tanzi, David L. Pauls, Generoso G. Gascon, Christine Stevens, Linda Lotspeich, John I. Nurnberger, Ramzi Nazir, Jonathan Green, Brian L. Yaspan, Marion Leboyer, Ann P. Thompson, Shun-Chiao Chang, Carolyn Bridgemohan, Louise Gallagher, Jeff Munson, Michael Gill, Guiqing Cai, Fritz Poustka, Regina Regan, Aislyn Cangialose, Gerard D. Schellenberg, Christopher J. McDougle, Christina Corsello, Wendy Roberts, Thomas H. Wassink, Majid Ghadami, Ellen M. Hanson, Benjamin M. Neale, Stacey Gabriel, Lonnie Zwaigenbaum, John Tsiantis, Hanna Ebeling, Sabine M. Klauck, Elaine LeClair, Bernie Devlin, Steven A. McCarroll, Ashley O'Connor, Andrew Pickles, Emily L. Crawford, Katja Jussila, Helen McConachie, Christopher Gillberg, Brenda E. Barry, Lou Kunkel, Seung Yun Yoo, Jennifer N. Partlow, Stephanie Brewster O'Neil, Ingrid A. Holm, Judith Miller, Guy A. Rouleau, Val C. Sheffield, Catherine Lord, Judith S. Palfrey, Ellen M. Wijsman, Astrid M. Vicente, Azam Hosseinipour, Ronald E. Becker, James S. Sutcliffe, Fred R. Volkmar, Marja Leena Mattila, Katerina Papanikolaou, Jennifer Reichert, Edwin H. Cook, Pamela Sklar, Elena Maestrini, Hilary Coon, Sek Won Kong, Stephen A. Haddad, Todd Green, Gillian Baird, Andrew Kirby, Patrick Bolton, Robert Sean Hill, Eric M. Morrow, Tom Berney, Jonathan L. Haines, Maryam Valujerdi, Casey Gates, David J. Posey, Karola Rehnström, Alistair T. Pagnamenta, Christine M. Freitag, Eric Fombonne, Janice Ware, Christian R. Marshall, Janine A. Lamb, Lauren A. Weiss, Agatino Battaglia, Nancy J. Minshew, Roksana Sasanfar, Elizabeth Baroni, Maretha de Jonge, Lennart von Wendt, Gina Hilton, Dalila Pinto, Nahit Motavalli Mukaddes, Ala Tolouei, Catalina Betancur, Michael Rutter, Tram Tran, Eftichia Duketis, Laurent Mottron, Margaret A. Pericak-Vance, Kristen West, Joachim Hallmayer, Kirsty Wing, Kerstin Wittemeyer, Rachel J. Hundley, Herman van Engeland, Judith Conroy, Mark J. Daly, Asif Hashmi, Michael L. Cuccaro, Geraldine Dawson, Sanna Kuusikko, Richard Anney, Anthony P. Monaco, Brian Winkloski, Samira Al-Saad, Dan E. Arking, Veronica J. Vieland, Stephen W. Scherer, Soher Balkhy, Kara Andresen, Rebecca L. Tomlinson, Joseph D. Buxbaum, Aravinda Chakravarti, Xiao-Qing Liu, Lindsay Jackson, Jaakko Ignatius, Catarina Correia, Leonard Rappaport, Heather Peters, Julie Gauthier, John R. Gilbert, Jeremy R. Parr, Carrie Sougnez, Katherine E. Tansey, Bennett L. Leventha, Annemarie Poustka, Daniel H. Geschwind, Annette Estes, Leena Peltonen, Maryam Rostami, Jeff Salt, David Altshuler, Simon Wallace, Susan E. Bryson, William M. Mahoney, Katy Renshaw, Robert M. Joseph, Lisa H. Albers, Inês Cabrito, Sean Ennis, Vanessa Hus, Guiomar Oliveira, Ann Le Couteur, Joseph Piven, Sandra L. Friedman, Penny Farrar, Joshua M. Korn, Sven Bölte, Camille W. Brune, Esau Simmons, Susan L. Santangelo, Andrew D. Paterson, Rita M. Cantor, Andrew B. West, Finny G Kuruvilla, Tiago R. Magalhaes, Andrew Green, Alison Schonwald, Stephen J. Guter, Anthony J. Bailey, Bernadette Rogé, William M. McMahon, Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Johns Hopkins University (JHU), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Génétique de l'autisme = Genetics of Autism (NPS-01), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Betancur, Catalina, University of Helsinki, Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), WEISS LA, ARKING DE, and GENE DISCOVERY PROJECT OF JOHNS HOPKINS & THE AUTISM CONSORTIUM, DALY MJ, CHAKRAVARTI A, BRUNE CW, WEST K, O'CONNOR A, HILTON G, TOMLINSON RL, WEST AB, COOK EH JR, CHAKRAVARTI A, WEISS LA, GREEN T, CHANG SC, GABRIEL S, GATES C, HANSON EM, KIRBY A, KORN J, KURUVILLA F, MCCARROLL S, MORROW EM, NEALE B, PURCELL S, SASANFAR R, SOUGNEZ C, STEVENS C, ALTSHULER D, GUSELLA J, SANTANGELO SL, SKLAR P, TANZI R, DALY MJ, ANNEY R, BAILEY AJ, BAIRD G, BATTAGLIA A, BERNEY T, BETANCUR C, BÖLTE S, BOLTON PF, BRIAN J, BRYSON SE, BUXBAUM JD, CABRITO I, CAI G, CANTOR RM, COOK EH JR, COON H, CONROY J, CORREIA C, CORSELLO C, CRAWFORD EL, CUCCARO ML, DAWSON G, DE JONGE M, DEVLIN B, DUKETIS E, ENNIS S, ESTES A, FARRAR P, FOMBONNE E, FREITAG CM, GALLAGHER L, GESCHWIND DH, GILBERT J, GILL M, GILLBERG C, GOLDBERG J, GREEN A, GREEN J, GUTER SJ, HAINES JL, HALLMAYER JF, HUS V, KLAUCK SM, KORVATSKA O, LAMB JA, LASKAWIEC M, LEBOYER M, COUTEUR AL, LEVENTHAL BL, LIU XQ, LORD C, LOTSPEICH LJ, MAESTRINI E, MAGALHAES T, MAHONEY W, MANTOULAN C, MCCONACHIE H, MCDOUGLE CJ, MCMAHON WM, MARSHALL CR, MILLER J, MINSHEW NJ, MONACO AP, MUNSON J, NURNBERGER JI JR, OLIVEIRA G, PAGNAMENTA A, PAPANIKOLAOU K, PARR JR, PATERSON AD, PERICAK-VANCE MA, PICKLES A, PINTO D, PIVEN J, POSEY DJ, POUSTKA A, POUSTKA F, REGAN R, REICHERT J, RENSHAW K, ROBERTS W, ROGE B, RUTTER ML, SALT J, SCHELLENBERG GD, SCHERER SW, SHEFFIELD V, SUTCLIFFE JS, SZATMARI P, TANSEY K, THOMPSON AP, TSIANTIS J, VAN ENGELAND H, VICENTE AM, VIELAND VJ, VOLKMAR F, WALLACE S, WASSINK TH, WIJSMAN EM, WING K, WITTEMEYER K, YASPAN BL, ZWAIGENBAUM L, MORROW EM, YOO SY, HILL RS, MUKADDES NM, BALKHY S, GASCON G, AL-SAAD S, HASHMI A, WARE J, JOSEPH RM, LECLAIR E, PARTLOW JN, BARRY B, WALSH CA, PAULS D, MOILANEN I, EBELING H, MATTILA ML, KUUSIKKO S, JUSSILA K, IGNATIUS J, SASANFAR R, TOLOUEI A, GHADAMI M, ROSTAMI M, HOSSEINIPOUR A, VALUJERDI M, SANTANGELO SL, ANDRESEN K, WINKLOSKI B, HADDAD S, KUNKEL L, KOHANE Z, TRAN T, KONG SW, O'NEIL SB, HANSON EM, HUNDLEY R, HOLM I, PETERS H, BARONI E, CANGIALOSE A, JACKSON L, ALBERS L, BECKER R, BRIDGEMOHAN C, FRIEDMAN S, MUNIR K, NAZIR R, PALFREY J, SCHONWALD A, SIMMONS E, RAPPAPORT LA, GAUTHIER J, MOTTRON L, JOOBER R, FOMBONNE E, ROULEAU G, REHNSTROM K, VON WENDT L, PELTONEN L.

Subjects
Perturbação Autística, Internationality, Genetic Linkage, Genome-wide association study, MESH: Semaphorins, Semaphorins, [SDV.GEN] Life Sciences [q-bio]/Genetics, 0302 clinical medicine, Neurodevelopmental disorder, Heritability of autism, MESH: Nerve Tissue Proteins, Association mapping, Genetics, 0303 health sciences, Multidisciplinary, MESH: Polymorphism, Single Nucleotide, MESH: Genetic Predisposition to Disease, Brain, Chromosome Mapping, Chromosomes, Human, Pair 5, MESH: Membrane Proteins, MESH: Chromosomes, Human, Pair 5, MESH: Autistic Disorder, MESH: Genetic Linkage, Single-nucleotide polymorphism, Nerve Tissue Proteins, Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, MESH: Brain, Genetic linkage, medicine, Humans, Genetic Predisposition to Disease, Autistic Disorder, MESH: Sample Size, 030304 developmental biology, Genetic association, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, Membrane Proteins, medicine.disease, Sample Size, Perturbações do Desenvolvimento Infantil e Saúde Mental, MESH: Genome-Wide Association Study, MESH: Internationality, Autism, MESH: Chromosome Mapping, Predisposição Genética para Doença, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Member of the Autism Genome Project Consortium: Astrid M. Vicente Although autism is a highly heritable neurodevelopmental disorder, attempts to identify specific susceptibility genes have thus far met with limited success. Genome-wide association studies using half a million or more markers, particularly those with very large sample sizes achieved through meta-analysis, have shown great success in mapping genes for other complex genetic traits. Consequently, we initiated a linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms (SNPs) in a common set of 1,031 multiplex autism families (1,553 affected offspring). We identified regions of suggestive and significant linkage on chromosomes 6q27 and 20p13, respectively. Initial analysis did not yield genome-wide significant associations; however, genotyping of top hits in additional families revealed an SNP on chromosome 5p15 (between SEMA5A and TAS2R1) that was significantly associated with autism (P = 2 x 10(-7)). We also demonstrated that expression of SEMA5A is reduced in brains from autistic patients, further implicating SEMA5A as an autism susceptibility gene. The linkage regions reported here provide targets for rare variation screening whereas the discovery of a single novel association demonstrates the action of common variants.

Published
2009

11. Ready for avian flu?

Author

Alice Dautry, Mark Walport, Tadataka Yamada, Bill & Melinda Gates Foundation's Global Health Program, Bill & Melinda Gates Foundation [Seattle], Institut Pasteur [Paris] (IP), Wellcome Trust, and Institut Pasteur [Paris]

Subjects
History, Research groups, Internationality, MESH: Influenza A Virus, H5N1 Subtype, Influenza vaccine, medicine.disease_cause, World health, MESH: Population Surveillance, MESH: Influenza Vaccines, Birds, 03 medical and health sciences, 0302 clinical medicine, MESH: Influenza in Birds, Influenza, Human, medicine, Animals, Humans, MESH: Animals, 030212 general & internal medicine, 030304 developmental biology, 0303 health sciences, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Multidisciplinary, MESH: Humans, Influenza A Virus, H5N1 Subtype, business.industry, MESH: Influenza, Human, Public relations, Influenza pandemic, Transparency (behavior), Virology, Influenza A virus subtype H5N1, Checklist, Intellectual Property, 3. Good health, Influenza Vaccines, Influenza in Birds, Population Surveillance, MESH: Birds, MESH: Internationality, MESH: Intellectual Property, business
Abstract

Committing to a vaccine stockpile is just the beginning. Tadataka Yamada, Alice Dautry and Mark Walport offer a roadmap for heading off a global avian influenza catastrophe. The 'official' influenza vaccine failed this year. Each year the World Health Organization selects strains for the vaccine based on epidemiological data. Most of the time it works, but what can be done to prevent future failures? Steven Salzberg thinks the answer lies in better tracking of virus mutations. This means that some research groups need to change their ways. Instead of guarding their data, the priority should be the rapid dissemination of genome sequence data on all isolates — human and avian. More transparency is one of the recommendations made by Yamada et al. in a checklist on how we should prepare for the next influenza pandemic. Other suggestions include stockpiling standard (inter-pandemic) flu vaccine, a special pricing model for poor countries, and improved surveillance mechanisms. For more on this week's Commentaries, visit the podcast page.

Published
2008

12. [The framing on human stem cells research under the screen of French Parliament]

Author

Bénédicte, de Boischevalier, Duchange, Nathalie, Département Recherche Clinique et Thérapeutique, Mission Ethique (DRCT), and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Internationality, MESH: Humans, Oocyte Donation, [SDV.ETH] Life Sciences [q-bio]/Ethics, [SDV.ETH]Life Sciences [q-bio]/Ethics, MESH: France, Embryo Research, MESH: Research Embryo Creation, Research Support as Topic, MESH: Women's Rights, MESH: European Union, MESH: Internationality, Humans, Women's Rights, Female, Research Embryo Creation, MESH: Embryo Research, MESH: Research Support, European Union, France, MESH: Oocyte Donation, MESH: Embryonic Stem Cells, MESH: Female, Embryonic Stem Cells, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

13. Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002

Author

Victoria Lewis, Katharina Stoeck, Markus Glatzel, Vittorio Mellina, Pascual Sánchez-Juan, Steven J. Collins, Jean-Philippe Brandel, Inga Zerr, N. Delasnerie-Laupretre, Javier Almazán, Jesús de Pedro-Cuesta, Cornelia M. van Duijn, Gerard H. Jansen, Herbert Budka, Ellen Gelpi, Michael B. Coulthart, Maurizio Pocchiari, Hans A Kretszchmar, Annick Alpérovitch, Maria Puopolo, Eva Mitrova, Unión Europea. Comisión Europea. 6 Programa Marco, Departamento de Epidemiologia Aplicada, Instituto de Salud Carlos III [Madrid] (ISC)-Centro Nacional de Epidemiologia, Institute of Neuropathology, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), University hospital of Zurich [Zurich], Registry of Creutzfeldt-Jakob disease -Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita [Rome], Department of Neurology, Georg-August-University [Göttingen], Department of Neuropathology, Ludwig-Maximilians-Universität München (LMU), Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Biostatistics, ERASMUS, Australian National Creutzfeldt-Jakob disease Registry, Department of Pathology, University of Melbourne, CJD Surveillance System, Division of Host Genetics and Prion Diseases, Public Health Agency of Canada, Institute of Neurology, Universität Wien-Austrian Reference Centre for Human Prion Diseases, Research base of Slovak Medical University, Slovak Medical University of Bratislava (SMU), This study was funded through NeuroPrion, an EU Network of Excellence funded by Framework 6 Programme, Contract number: FOOD CT 2004 056579, and EUROCJD funded by DG SANCO, Contract number: 2003201., Istituto Superiore di Sanità (ISS), Georg-August-University = Georg-August-Universität Göttingen, Epidemiology, and Autard, Delphine

Subjects
MESH: Re, Internationality, animal diseases, Iatrogenic Disease, Creutzfeldt-Jakob Syndrome, MESH: Magnetic Resonance Imaging, MESH: Genotype, 0302 clinical medicine, MESH: Cross-Cultural Comparison, Medicine, Registries, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, 0303 health sciences, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, lcsh:Public aspects of medicine, Electroencephalography, Magnetic Resonance Imaging, MESH: Iatrogenic Disease, 3. Good health, Europe, Italy, Population Surveillance, MESH: Great Britain, France, Prion Proteins, 44.90, Research Article, Cross-Cultural Comparison, Canada, Slovakia, 616.8, Genotype, Prions, MESH: Australia, MESH: Population Surveillance, Time, 03 medical and health sciences, MESH: Prions, MESH: Canada, Neurologie, MESH: Electroencephalography, mental disorders, Iatrogenic disease, Humans, 030304 developmental biology, MESH: Humans, business.industry, Australia, Public Health, Environmental and Occupational Health, MED 530, MESH: Italy, lcsh:RA1-1270, MESH: Creutzfeldt-Jakob Syndrome, Virology, United Kingdom, nervous system diseases, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Internationality, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, 030217 neurology & neurosurgery
Abstract

Background The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. Methods From data collected for surveillance purposes, we describe annual proportions of deaths due to different human transmissible spongiform encephalopathies in eleven EUROCJD-consortium countries over the period 1993–2002, as well as variations in the use of diagnostic tests. Using logistic models we quantified international differences and changes across time. Results In general, pre-mortem use of diagnostic investigations increased with time. International differences in pathological confirmation of sporadic Creutzfeldt-Jakob disease, stable over time, were evident. Compared to their counterparts, some countries displayed remarkable patterns, such as: 1) the high proportion, increasing with time, of variant Creutzfeldt-Jakob disease in the United Kingdom, (OR 607.99 95%CI 84.72–4363.40), and France (OR 18.35, 95%CI 2.20–152.83); 2) high, decreasing proportions of iatrogenic Creutzfeldt-Jakob disease in France, (OR 5.81 95%CI 4.09–8.24), and the United Kingdom, (OR 1.54 95%CI 1.03–2.30); and, 3) high and stable ratios of genetic forms in Slovakia (OR 21.82 95%CI 12.42–38.33) and Italy (OR 2.12 95%CI 1.69–2.68). Conclusion Considerable international variation in aetiological subtypes of human transmissible spongiform encephalopathies was evident over the observation period. With the exception of variant Creutzfeldt-Jakob disease and iatrogenic Creutzfeldt-Jakob disease in France and the United Kingdom, these differences persisted across time.

Published
2006

14. Protecting Vulnerable Road Users from Injury

Author

Emmanuel Lagarde, Aymery Constant, Autard, Delphine, Epidémiologie et Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2, Equipe avenir, prévention et prise en charge des traumatismes, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2

Subjects
MESH: Accidents, Traffic, Internationality, Public Health and Epidemiology/Environmental Health, Injury control, Accident prevention, Internet privacy, Public Health and Epidemiology, lcsh:Medicine, Poison control, MESH: Public Policy, Public Policy, Walking, Public Health and Epidemiology/Health Policy, MESH: Bicycling, MESH: Motorcycles, Energy absorption, Injury prevention, MESH: Walking, Humans, MESH: Data Collection, Crash data, ComputingMilieux_MISCELLANEOUS, Critical Care and Emergency Medicine/Trauma, Road user, Policy Forum, MESH: Humans, business.industry, Data Collection, lcsh:R, Accidents, Traffic, Public Health and Epidemiology/Global Health, General Medicine, Bicycling, Motorcycles, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Internationality, Public Health and Epidemiology/Preventive Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Business, Alcohol consumption
Abstract

Aymery Constant and Emmanuel Lagarde discuss policies to protect pedestrians, and pedal and motor cyclists, from injury.

Published
2010

15. Crédits, cauchemars et nuits blanches

Author

Hervé Chneiweiss, Chaire Neuropharmacologie (INSERM U114), Collège de France (CdF (institution)), Maylin, Françoise, and Collège de France - Chaire Neuropharmacologie (INSERM U114)

Subjects
MESH: France, 0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, MESH: Internationality, MESH: Research Support, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], General Medicine, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030217 neurology & neurosurgery, General Biochemistry, Genetics and Molecular Biology, 030304 developmental biology
Abstract

> C’est un cauchemar si habituel qu’il ne viendrait a l’esprit d’aucun scientifique de s’en offusquer ou meme d’imaginer qu’il puisse en etre autrement. Une large partie de la vie d’un chercheur est consacree a rediger des demandes de credits, puis attendre la reponse... trop souvent tardive, negative, ou amputee de la moitie des credits. Eclosion ou explosion, le developpement du systeme est encore recent en France, mais son rythme de croissance soutenu nous a permis de nous hisser tres rapidement au plus haut niveau international. Les organismes de recherche et les associations caritatives avaient deja ouverts le bal depuis longtemps, mais le tempo restait lent, sur une base annuelle, permettant quelques periodes de pointe, autour du 15 octobre ou du 15 mars, apres quoi tout redevenait calme. Trop calme manifestement. On vit d’abord apparaitre, et monter en regime, au cours des annees 90, les appels d’offre du ministere, avec une nette acceleration dans le cadre du Fond National de la Science (FNS) ou du Fond de Recherche Technologique (FRT). Et puis les Regions, les Universites, les organismes de nouveau, les nouvelles agences et les grands programmes par eux-memes, declines en GIS ou GIP, se lancerent dans la danse. Comme la communaute se plaignait de ne pouvoir tenir le rythme, la belle orchestration des Etats Generaux de Grenoble en 2004 (➜) demanda une pause et un seul chef d’orchestre. Alors vint l’ANR et son nouvel appel d’offre subquotidien, sur lequel enchaina l’evaluation desdits appels d’offre. Une fois, deux fois, trois fois car il semble que meme l’informatique ait des soucis pour suivre la cadence ! Certains eurent meme bientot leur propre projet de recherche a evaluer ! La boucle etait bouclee : un jour j’ecris, le lendemain j‘evalue, le troisieme temps de la valse etant consacre a des reunions destinees a preparer, corriger le texte d’annonce, choisir les evaluateurs ou evaluer l’evaluation des appels d’offre. On pourrait croire la caricature trop typique du systeme francofrancais et de son besoin permanent de multiplier les couches du millefeuilles administratif. Le numero du 14 septembre dernier de la revue Nature [1] nous rassure : le cauchemar est international ! Et loin d’etre un privilege reserve aux biologistes. Faire l’aveu que l’on considere la reponse aux appels d’offre comme la pire partie de notre metier est une telle honte, la peur des retorsion vis-a-vis de la « main qui vous nourrit » MEDECINE/SCIENCES 2005 ; 21 : 1115-6

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