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9. Additional file 1 of 13C15N: glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans

Author

Renuse, Santosh, Benson, Linda M., Vanderboom, Patrick M., Ruchi, F. N. U., Yadav, Yogesh R., Johnson, Kenneth L., Brown, Benjamin C., Peterson, Jane A., Basu, Rita, McCormick, Daniel J., Pandey, Akhilesh, and Basu, Ananda

Abstract

Additional file 1: Figure S1. Representative MS/MS spectra showing mapped b-ions for ions for endogenous glucagon (pink color), F22 glucagon (spike-in standard) (blue color), FF glucagon (brown color) and FFLA glucagon (green color) for respective b253+ ions (panel A), b263+ ions (panel B) and b273 + ions (panel C).

Published
2022
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14. Preeclamptic women have decreased circulating IL-10 values at the time of preeclampsia diagnosis: Systematic review and meta-analysis

Author

Nath, Meryl C., Cubro, Hajrunisa, McCormick, Daniel J., Milic, Natasa M., and Garovic, Vesna D.

Subjects
Adult, Pre-Eclampsia, Pregnancy, Hypertension, Humans, Blood Pressure, Female, Article, Biomarkers, Interleukin-10
Abstract

A key immunomodulatory cytokine, Interleukin-10 (IL-10), has been shown to be dysregulated in preeclampsia, a pregnancy-specific hypertensive disorder, further characterized by multi-system involvement. However, studies have reported inconsistent findings about circulating IL-10 levels in preeclamptic versus normotensive pregnancies. The aim of the present systematic review and meta-analysis was to assess circulating IL-10 levels in preeclamptic and normotensive pregnancies at two time points: before, and at the time of preeclampsia diagnosis. PubMED, EMBASE and Web of Science databases were searched to include all published studies examining circulating IL-10 levels in preeclamptic and normotensive pregnancies. Differences in IL-10 levels were evaluated by standardized mean differences (SMD). Of 876 abstracts screened, 56 studies were included in the meta-analysis. Circulating IL-10 levels were not different before the time of active disease (SMD: −0.01, 95% confidence interval [CI]: −0.11, 0.08; P = 0.76). At the time of active disease, women with preeclampsia (n=1599) had significantly lower IL-10 levels compared to normotensive controls (n=1998) (SMD: −0.79, 95% CI: −1.22, −0.35; P = 0.0004). IL-10 levels were lower in both early/severe and late/mild forms of preeclampsia. Subgroup analysis revealed that IL-10 measurement methodology (ELISA or multiplex bead array) and the sample type (plasma or serum) significantly influenced the observed differences, with the use of sera paired with ELISA technology providing the best distinction in IL-10 levels between preeclamptic and normotensive pregnancies. These findings support the role of decreased IL-10 levels in the pathophysiology of preeclampsia. Future studies should address the therapeutic potential of IL-10 in preeclampsia.

Published
2020

16. 13C15N: glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans.

Author

Renuse, Santosh, Benson, Linda M., Vanderboom, Patrick M., Ruchi, F. N. U., Yadav, Yogesh R., Johnson, Kenneth L., Brown, Benjamin C., Peterson, Jane A., Basu, Rita, McCormick, Daniel J., Pandey, Akhilesh, and Basu, Ananda

Subjects
GLUCAGON, MASS spectrometry, ISOTOPE dilution analysis, TYPE 1 diabetes, ARTIFICIAL pancreases, BLOOD sugar monitoring, DILUTION, PSYCHOLOGICAL feedback
Abstract

Background: Glucagon serves as an important regulatory hormone for regulating blood glucose concentration with tight feedback control exerted by insulin and glucose. There are critical gaps in our understanding of glucagon kinetics, pancreatic α cell function and intra-islet feedback network that are disrupted in type 1 diabetes. This is important for translational research applications of evolving dual-hormone (insulin + glucagon) closed-loop artificial pancreas algorithms and their usage in type 1 diabetes. Thus, it is important to accurately measure glucagon kinetics in vivo and to develop robust models of glucose-insulin-glucagon interplay that could inform next generation of artificial pancreas algorithms. Methods: Here, we describe the administration of novel 13C15N heavy isotope-containing glucagon tracers—FF glucagon [(Phe 6 13C9,15N; Phe 22 13C9,15N)] and FFLA glucagon [(Phe 6 13C9,15N; Phe 22 13C9,15N; Leu 14 13C6,15N; Ala 19 13C3)] followed by anti-glucagon antibody-based enrichment and LC–MS/MS based-targeted assays using high-resolution mass spectrometry to determine levels of infused glucagon in plasma samples. The optimized assay results were applied for measurement of glucagon turnover in subjects with and without type 1 diabetes infused with isotopically labeled glucagon tracers. Results: The limit of quantitation was found to be 1.56 pg/ml using stable isotope-labeled glucagon as an internal standard. Intra and inter-assay variability was < 6% and < 16%, respectively, for FF glucagon while it was < 5% and < 23%, respectively, for FFLA glucagon. Further, we carried out a novel isotope dilution technique using glucagon tracers for studying glucagon kinetics in type 1 diabetes. Conclusions: The methods described in this study for simultaneous detection and quantitation of glucagon tracers have clinical utility for investigating glucagon kinetics in vivo in humans. [ABSTRACT FROM AUTHOR]

Published
2022
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17. 152-OR: Postabsorptive Splanchnic and Leg Glucagon Metabolism in Healthy Subjects: Use of 13C 15N Glucagon

Author

RUCHI, FNU, primary, YADAV, YOGESH R., additional, ROMERES, DAVIDE, additional, SAWLEH, SAFIA, additional, BENSON, LINDA M., additional, JOHNSON, KENNETH L., additional, MAN, CHIARA DALLA, additional, COBELLI, CLAUDIO, additional, MCCORMICK, DANIEL J., additional, WILKINS, LUKE R., additional, BASU, RITA, additional, and BASU, ANANDA, additional

Published
2020
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18. 1910-P: Effects of Glucagon Concentrations on Splanchnic and Leg Glucagon Extraction in Healthy Humans

Author

RUCHI, FNU, primary, YADAV, YOGESH R., additional, ROMERES, DAVIDE, additional, SAWLEH, SAFIA, additional, BENSON, LINDA M., additional, JOHNSON, KENNETH L., additional, MAN, CHIARA DALLA, additional, COBELLI, CLAUDIO, additional, MCCORMICK, DANIEL J., additional, WILKINS, LUKE R., additional, BASU, RITA, additional, and BASU, ANANDA, additional

Published
2020
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22. Hemoglobin Old Dominion/Burton-upon-Trent, beta 143 (H21) His[right arrow]Tyr, Codon 143 CAC[right arrow]TAC-a Variant With Altered Oxygen Affinity That Compromises Measurement of Glycated Hemoglobin in Diabetes Mellitus: Structure, Function, and DNA Sequence

Author

Elder, G. Elizabeth, Lappin, Terry R. J., Horne, Allen B., Fairbanks, Virgil F., Jones, Richard T., Winter, Paul C., Green, Brian N., Hoyer, James D., Reynolds, Timothy M., Shih, Daniel T.-B., McCormick, Daniel J., Kubik, Kathleen S., Madden, Benjamin J., Head, Charlotte G., Harvey, D., and Roberts, Norman B.

Published
1998

24. Calmodulin interacts with amphiphilic peptides composed of all D-amino acids

Author

Fisher, Phyllis J., Prendergast, Franklyn G., Ehrhardt, Mark R., Urbauer, Jeffrey L., Wand, A. Joshua, Sedarous, Salah S., McCormick, Daniel J., and Buckley, Paul

Subjects
Calmodulin -- Research, Amino acid sequence -- Analysis, Cooperative binding (Biochemistry) -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Use of melittin and RS20 that contain only D-amino acids indicates that calmodulin binds avidly to both, revealing the high sterical tolerance of the calmodulin-peptide binding surface. This may lead to the development of non- or slowly-hydrolysable calmodulin inhibitors that function at the intracellular level. The binding site is the same as that for peptides possessing L-amino acids.

Published
1994

27. Identification of Biomarkers for PKD1 Using Urinary Exosomes

Author

Hogan, Marie C., primary, Bakeberg, Jason L., additional, Gainullin, Vladimir G., additional, Irazabal, Maria V., additional, Harmon, Amber J., additional, Lieske, John C., additional, Charlesworth, M. Cristine, additional, Johnson, Kenneth L., additional, Madden, Benjamin J., additional, Zenka, Roman M., additional, McCormick, Daniel J., additional, Sundsbak, Jamie L., additional, Heyer, Christina M., additional, Torres, Vicente E., additional, Harris, Peter C., additional, and Ward, Christopher J., additional

Published
2015
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28. Proximal Versus Distal Embolic Protection for Carotid Artery Stenting

Author

Giri, Jay, primary, Parikh, Sahil A., additional, Kennedy, Kevin F., additional, Weinberg, Ido, additional, Donaldson, Cameron, additional, Hawkins, Beau M., additional, McCormick, Daniel J., additional, Jackson, Benjamin, additional, Armstrong, Ehrin J., additional, Ramchand, Preethi, additional, White, Christopher J., additional, Jaff, Michael R., additional, Rosenfield, Kenneth, additional, and Yeh, Robert W., additional

Published
2015
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30. Comparison of Trends and Outcomes of Carotid Artery Stenting and Endarterectomy in the United States, 2001 to 2010

Author

Kim, Luke K, primary, Yang, David C., additional, Swaminathan, Rajesh V., additional, Minutello, Robert M., additional, Okin, Peter M., additional, Lee, Min Kyeong, additional, Sun, Xuming, additional, Wong, S. Chiu, additional, McCormick, Daniel J., additional, Bergman, Geoffrey, additional, Allareddy, Veerasathpurush, additional, Singh, Harsimran, additional, and Feldman, Dmitriy N., additional

Published
2014
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36. Hemoglobin Old Dominion/Burton-upon-Trent, β143 (H21) His→Tyr, Codon 143 CAC→TAC—a Variant With Altered Oxygen Affinity That Compromises Measurement of Glycated Hemoglobin in Diabetes Mellitus: Structure, Function, and DNA Sequence

Author

Elder, G. Elizabeth, primary, Lappin, Terry R.J., additional, Horne, Allen B., additional, Fairbanks, Virgil F., additional, Jones, Richard T., additional, Winter, Paul C., additional, Green, Brian N., additional, Hoyer, James D., additional, Reynolds, Timothy M., additional, Shih, Daniel T.-B., additional, McCormick, Daniel J., additional, Kubik, Kathleen S., additional, Madden, Benjamin J., additional, Head, Charlotte G., additional, Harvey, D., additional, and Roberts, Norman B., additional

Published
1998
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37. Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis

Author

Martins, Luis M., primary, Mesner, Peter W., additional, Kottke, Timothy J., additional, Basi, Guriqbal S., additional, Sinha, Sukanto, additional, Tung, Jay S., additional, Svingen, Phyllis A., additional, Madden, Benjamin J., additional, Takahashi, Atsushi, additional, McCormick, Daniel J., additional, Earnshaw, William C., additional, and Kaufmann, Scott H., additional

Published
1997
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38. Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

Author

Martins, Luis M., primary, Kottke, Timothy, additional, Mesner, Peter W., additional, Basi, Guriqbal S., additional, Sinha, Sukanto, additional, Frigon, Normand, additional, Tatar, Eric, additional, Tung, Jay S., additional, Bryant, Karin, additional, Takahashi, Atsushi, additional, Svingen, Phyllis A., additional, Madden, Benjamin J., additional, McCormick, Daniel J., additional, Earnshaw, William C., additional, and Kaufmann, Scott H., additional

Published
1997
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44. Comparative Effectiveness of Commonly Used Devices for Carotid Artery Stenting An NCDR Analysis (National Cardiovascular Data Registry)

Author

Giri, Jay, Kennedy, Kevin F., Weinberg, Ido, Hawkins, Beau M., Press, Marcella Calfon, Drachman, Douglas, McCormick, Daniel J., Aronow, Herbert D., White, Christopher J., Rosenfield, Kenneth, and Yeh, Robert W.

Subjects
embolic protection devices, carotid artery stenting, carotid artery stenosis
Abstract

ObjectivesThis study sought to characterize usage and outcomes of carotid stenting platforms.BackgroundA variety of stents and embolic protection devices (EPDs) are used for carotid artery stenting. Little is known about current usage patterns and differences in outcomes with these devices.MethodsWe analyzed 12,135 consecutive carotid stent procedures in the NCDR (National Cardiovascular Data Registry) CARE (Carotid Artery Revascularization and Endarterectomy) registry performed between January 1, 2007 and March 31, 2012. We compared baseline characteristics and crude and multivariable-adjusted rates of in-hospital combined death/stroke among patients treated with Acculink/Accunet (Abbott Laboratories, Abbott Park, Illinois), Xact/Emboshield (Abbott), and Precise/Angioguard (Cordis Corporation, Bridgewater, New Jersey) stent/EPD combinations.ResultsIn 78.2% of cases, stents were used in conjunction with their specific, corresponding U.S. Food and Drug Administration–approved EPD. The Acculink/Accunet (n = 2,617, 21.6%), Xact/Emboshield (n = 3,507, 28.9%), and Precise/Angioguard (n = 2,696, 22.2%) stent/EPD combinations were used in 72.7% of all cases. The Protégé/SpiderFx (ev3 Endovascular Inc., Plymouth, Minnesota) (n = 453, 3.7%) and Wallstent/Filterwire (Boston Scientific, Natick, Massachusetts) (n = 213, 1.8%) devices were used in a minority of cases. In unadjusted analyses, the Precise/Angioguard system was associated with higher rates of the primary outcome than were the Acculink/Accunet (2.5% vs. 1.8%; p = 0.058) and Xact/Emboshield (2.5% vs. 1.9%; p = 0.14) systems that were not statistically different. In adjusted analyses, differences between Precise/Angioguard and Accunet/Acculink (odds ratio [OR]: 1.48, 95% confidence interval [CI]: 0.89 to 2.47; p = 0.065), Precise/Angioguard and Xact/Emboshield (OR: 1.16, 95% CI: 0.77 to 1.76; p = 0.38), and Xact/Emboshield and Accunet/Acculink (OR: 1.28, 95% CI: 0.82 to 1.97; p = 0.18) remained nonsignificant.ConclusionsIn modern U.S. practice, the Acculink/Accunet, Xact/Emboshield, and Precise/Angioguard carotid stenting systems are used in most cases and are associated with similarly low rates of adverse events.

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45. Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo

Author

Tyler, Beth M, McCormick, Daniel J, Hoshall, Clark V, Douglas, Christopher L, Jansen, Karen, Lacy, Benjamin W, Cusack, Bernadette, and Richelson, Elliott

Abstract

Peptide nucleic acids (PNAs) are DNA analogs that can hybridize to complementary sequences with high affinity and stability. Here, we report the first evidence of intracellular delivery of PNAs in vivo. Two CNS receptors, an opioid (mu) and a neurotensin (NTR‐1), were targeted independently by repeated microinjection of PNAs into the periaqueductal gray. Behavioral responses to neurotensin (antinociception and hypothermia) and morphine (antinociception) were lost in a specific manner. Binding studies confirmed a large reduction in receptor sites. The loss of behavioral responses was long lasting but did fully recover. The implications of specifically and readily turning off gene expression in vivo are profound.

Published
1998
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46. Percutaneous balloon valvuloplasty of the pulmonary valve: Role of right to left shunting through a patent foramen ovale

Author

Shuck, John W., McCormick, Daniel J., Cohen, Ira S., Oetgen, William J., and Brinker, Jeffrey A.

Abstract

Percutaneous balloon valvuloplasty was performed on a patient with pulmonary stenosis. Right to left shunting through a patent foramen ovale during balloon inflation was documented by contrast two-dimensional echocardiography. Right and left ventricular pressures recorded during balloon inflation showed a decrease in left ventricular end-diastolic pressure and equilibration with right ventricular end-diastolic pressure. Systemic hypotension was minimal during balloon inflation, possibly due to persistent filling of the left ventricle via the patent foramen ovale. Persistent right ventricular systolic hypertension immediately after valvuloplasty may have been due to infundibular narrowing and resolved on restudy 2 weeks later.

Published
1984
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48. 1003-94 Rheolytic thrombectomy for the treatment of acute myocardial infarction in patients with angiographic large thrombus burden: One-year results of the VeGAS 2 acute myocardial infarction registry.

Author

Silva, Jose A, Ramee, Stephen R, Cohen, David, Carrozza, Joseph P, Popma, Jeffrey J, Dandreo, Kim, Lansky, Alexandra A, Baim, Donald S, George, Barry S, McCormick, Daniel J, Sefum, Cindy M, and Kuntz, Richard E

Subjects
*MYOCARDIAL infarction treatment, *ANGIOGRAPHY, *ECHOCARDIOGRAPHY, *MEDICAL registry personnel, *CLINICAL trials
Published
2004
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49. Multipeptide stimulated PBMCs generate T EM /T CM for adoptive cell therapy in multiple myeloma.

Author

Vardam-Kaur T, Pathangey LB, McCormick DJ, Bergsagel PL, Cohen PA, and Gendler SJ

Abstract

Multiple Myeloma (MM) patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses. Here we evaluate the possibility of adoptive cell transfer (ACT) by generating ex vivo T cells from peripheral blood mononuclear cells (PBMCs) isolated from MM patients by employing our previously devised protocols. We designed peptides from antigens (Ags) including cancer testis antigens (CTAs) that are over expressed in MM. We exposed PBMCs from different healthy donors (HDs) to single peptides. We observed reproducible Ag-specific cluster of differentiation 4 + (CD4 + ) and CD8 + T cell responses on exposure of PBMCs to different single peptide sequences. These peptide sequences were used to compile four different peptide cocktails. Naïve T cells from PBMCs from MM patients or HDs recognized the cognate Ag in all four peptide cocktails, leading to generation of multiclonal Ag-specific CD4 + and CD8 + effector and central memory T (T EM and T CM , respectively) cells which produced interferon-gamma (IFN-γ), granzyme B and perforin on secondary restimulation. Furthermore, this study demonstrated that immune cells from MM patients are capable of switching metabolic programs to induce effector and memory responses. Multiple peptides and cocktails were identified that induce IFN-γ + , T1-type, metabolically active T cells, thereby paving the way for feasibility testing of ACT in phase I clinical trials., Competing Interests: CONFLICTS OF INTEREST The authors declare no conflicts of interest., (Copyright: © 2021 Vardam-Kaur et al.)

Published
2021
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50. Myocardial revascularization in patients with left main coronary disease.

Author

Apostolidou E, Kalisetti D, Logani S, McCormick DJ, and Goldberg S

Subjects
Coronary Artery Bypass, Follow-Up Studies, Humans, Percutaneous Coronary Intervention, Treatment Outcome, Coronary Artery Disease therapy, Myocardial Revascularization
Abstract

While coronary artery bypass grafting (CABG) has been the standard of care for patients with unprotected left main coronary artery disease, advances in percutaneous coronary intervention (PCI) have made stent placement a reasonable alternative in selected patients. In this review, we address the results of studies comparing PCI with CABG, discuss the invasive evaluation of these patients, and the technical approach to percutaneous revascularization. Furthermore, we discuss future pivotal trials, which will help define long-term outcomes comparing PCI with surgery.

Published
2013

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