6 results on '"MA Asafa"'
Search Results
2. Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats
- Author
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Benson Akinloye Fadeyi, Modinat A. Adefisayo, MA Asafa, Quadri K. Alabi, Joseph Gbenga Omole, Oladele A. Ayoka, and Babalola Olusegun Olubunmi
- Subjects
Male ,antioxidant ,Antioxidant ,medicine.medical_treatment ,lcsh:RX1-681 ,030204 cardiovascular system & hematology ,Pharmacology ,medicine.disease_cause ,030226 pharmacology & pharmacy ,chemistry.chemical_compound ,0302 clinical medicine ,lcsh:Homeopathy ,Malondialdehyde ,biology ,lcsh:Other systems of medicine ,Glutathione ,Nitrogen mustard ,Leukemia ,Seeds ,Original Article ,medicine.drug ,cardiac troponin I ,Cyclophosphamide ,cardiotoxicity ,Garcinia kola ,Protective Agents ,03 medical and health sciences ,medicine ,Animals ,Humans ,Rats, Wistar ,kolaviron ,Antineoplastic Agents, Alkylating ,Flavonoids ,Cardiotoxicity ,Plant Extracts ,Superoxide Dismutase ,business.industry ,medicine.disease ,biology.organism_classification ,lcsh:RZ201-999 ,Rats ,Oxidative Stress ,Complementary and alternative medicine ,chemistry ,cyclophosphamide ,business ,Oxidative stress - Abstract
Background.Cyclophosphamide (CP) is a nitrogen mustard alkylating drug used for the treatment of chronic and acute malignant lymphomas, myeloma, leukemia, neuroblastoma, adenocarcinoma, retinoblastoma, breast carcinoma, and immunosuppressive therapy. Despite its vast therapeutic uses, it is known to cause severe cardiac toxicity. Kolaviron (KV), a Garcinia kola seed extract containing a mixture of flavonoids, is reputed for its antioxidant and membrane stabilizing properties.Objective.This study investigated the protective effect of KV on CP-induced cardiotoxicity in rats.Methods.Thirty rats were used, and they were divided into 6 groups of 5 rats each. Group I received 2 mL/kg propylene glycol orally for 14 days; group II received CP (50 mg/kg/d, intraperitoneally [i.p.]) for 3 days; groups III and IV received 200 and 400 mg/kg/d KV, respectively, orally for 14 days and groups V and VI were pretreated with 200 and 400 mg/kg/d KV, respectively, orally for 14 days followed by CP (50 mg/kg/d, i.p.) for 3 days.Results.CP treatment resulted in a significantly lower food consumption and body weight in rats. The lactate dehydrogenase and creatine kinase enzymes in cardiac tissues of rats treated with CP were significantly higher. In cardiac tissues, 3-day doses of CP resulted in significantly higher heart weight, cardiac troponin I, myeloperoxidase, malondialdehyde, hydrogen peroxide and lower superoxide dismutase, catalase, glutathione peroxidase activities, and reduced glutathione levels. Histological examination of cardiac tissues showed sign of necrosis of myocardium after CP treatment. However, administration of KV at 200 and 400 mg/kg for 14 days prior to CP treatment, increase food consumption, body weight, and attenuates the biochemical and histological changes induced by CP.Conclusions.These results revealed that KV attenuates CP-induced cardiotoxicity by inhibiting oxidative stress and preserving the activity of antioxidant enzymes.
- Published
- 2018
3. The role of electrocardiogram in the diagnosis of dextrocardia with mirror image atrial arrangement and ventricular position in a young adult Nigerian in Ile-Ife: a case report
- Author
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Adedayo I. Irinoye, Rufus O. Akomolafe, A. O. Ajao, Olumide S. Akinsomisoye, MA Asafa, A. O. Ayoka, and Oluwadare Ogunlade
- Subjects
Male ,medicine.medical_specialty ,Black People ,Nigeria ,Cardiomegaly ,Case Report ,Dextrocardia ,Inferior vena cava ,Apex beat ,Diagnosis, Differential ,Electrocardiography ,Young Adult ,QRS complex ,Right ventricular hypertrophy ,Internal medicine ,Abdomen ,medicine ,Humans ,Ultrasonography ,Medicine(all) ,Incidental Findings ,medicine.diagnostic_test ,Nigerian ,business.industry ,General Medicine ,Situs Inversus ,medicine.disease ,Precordium ,Electrocardiogram ,Surgery ,Viscera ,Situs inversus ,medicine.anatomical_structure ,medicine.vein ,Cardiology ,cardiovascular system ,business - Abstract
Introduction Dextrocardia with situs inversus is a rare congenital disease. In patients with this condition, the heart is presented as a mirror image of itself with its apex pointing to the right. The pulmonary and abdominal anatomies are reversed. Dextrocardia with situs inversus occurs at birth but its diagnosis may be in adulthood. This case advances knowledge by graphically describing the unusual electrocardiographic features of dextrocardia in a young adult. Case presentation We report a case of a 22-year-old Nigerian man of Yoruba ethnicity who presented himself for preadmission medical test. He had a standard 12-lead electrocardiogram which revealed uncommon features: inversion of P waves in leads I, aVL and aVR; dominantly negative QRS waves in leads I, V1 to V6; reverse R wave progression in chest leads; low voltage in V4 to V6; extreme QRS axis; flattened T waves in V4 to V6 and aVR; and inverted T waves in lead I and aVL. An electrocardiogram diagnosis of dextrocardia was made. The differential diagnosis considered was right ventricular hypertrophy. A cardiovascular examination showed pulse rate of 70 beats per minute, blood pressure of 119/62mmHg, visible cardiac impulse at right precordium, apex beat was located at his fifth right intercostal space mid-clavicular line. A chest X-ray (posterior anterior view) including upper abdomen showed dextrocardia; his aortic arch was located on the right. His stomach bubble was located below his right hemidiaphragm. His trachea was slightly deviated to the left. The findings in his lung fields were not remarkable. Abdominopelvic ultrasonography showed that right-sided intra-abdominal organs (liver, gallbladder) were located on the left while left-sided organs (stomach, spleen) were located on the right. His abdominal aorta was on the right while his inferior vena cava was located on the left. A diagnosis of dextrocardia with situs inversus was made ultrasonographically. Conclusions A properly interpreted electrocardiogram was useful in suspecting the diagnosis of dextrocardia with situs inversus. So, an analysis of a relatively simple and non-invasive diagnostic tool such as an electrocardiogram allows for suspicion of a cardiovascular anomaly in a setting of scarce diagnostic resources.
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4. The role of electrocardiogram in sex verification in a young adult with primary amenorrhea: a case report.
- Author
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Asafa MA, Bolarinwa RA, Eluwole OA, Ibitoye BO, Adegoke AM, and Ogunlade O
- Subjects
- Adult, Amenorrhea genetics, Female, Genitalia, Female diagnostic imaging, Humans, Karyotyping, Male, Testis diagnostic imaging, Ultrasonography, Cryptorchidism diagnostic imaging, Electrocardiography, Sex Determination Analysis
- Abstract
Background: The use of electrocardiogram for sex verification in adults is an emerging concept in medicine. It is feasible through the utilization of Ogunlade Sex Determination Electrocardiographic Score. The aim of this study was to use an electrocardiogram to verify the sex of a woman with primary amenorrhea., Case Presentation: We report a case of a 36-year-old woman of Yoruba ethnicity who presented with primary amenorrhea. A physical examination revealed a woman with a feminine appearance characterized by long plaited hair and well-developed breasts. As part of the investigations to unravel the sex status, she had a resting standard 12-lead electrocardiogram which revealed a masculine electrocardiogram pattern with Ogunlade Sex Determination Electrocardiographic Score of 9 (T-wave pattern in lead V
1 , 3; ST segment in lead V2 or V3 , 3; QRS rotation, 2; heart rate of 79, 1). An abdominopelvic ultrasonography done by a radiologist showed absence of uterus, fallopian tubes, and ovaries. When our patient was considered for transvaginal scan, she declined but embraced translabial ultrasound as she claimed to be a virgin. Translabial ultrasonography revealed the presence of undescended hypoplastic testes with associated testicular microlithiasis at the external inguinal rings bilaterally. Karyotyping using a blood sample revealed 46,XY and a sex-determining region Y report showed that the blood sample was positive for the SRY gene confirming the status as male. This synchronized with the initial electrocardiogram evaluation. The testes were later removed., Conclusion: This report concluded that an electrocardiogram as a cheap, readily available and non-invasive test has a role in sex verification in young adults with primary amenorrhea.- Published
- 2018
- Full Text
- View/download PDF
5. Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats.
- Author
-
Omole JG, Ayoka OA, Alabi QK, Adefisayo MA, Asafa MA, Olubunmi BO, and Fadeyi BA
- Subjects
- Animals, Cardiotoxicity etiology, Cardiotoxicity metabolism, Glutathione metabolism, Humans, Male, Malondialdehyde metabolism, Oxidative Stress drug effects, Rats, Rats, Wistar, Seeds chemistry, Superoxide Dismutase metabolism, Antineoplastic Agents, Alkylating adverse effects, Cardiotoxicity prevention & control, Cyclophosphamide adverse effects, Flavonoids administration & dosage, Garcinia kola chemistry, Plant Extracts administration & dosage, Protective Agents administration & dosage
- Abstract
Background: Cyclophosphamide (CP) is a nitrogen mustard alkylating drug used for the treatment of chronic and acute malignant lymphomas, myeloma, leukemia, neuroblastoma, adenocarcinoma, retinoblastoma, breast carcinoma, and immunosuppressive therapy. Despite its vast therapeutic uses, it is known to cause severe cardiac toxicity. Kolaviron (KV), a Garcinia kola seed extract containing a mixture of flavonoids, is reputed for its antioxidant and membrane stabilizing properties., Objective: This study investigated the protective effect of KV on CP-induced cardiotoxicity in rats., Methods: Thirty rats were used, and they were divided into 6 groups of 5 rats each. Group I received 2 mL/kg propylene glycol orally for 14 days; group II received CP (50 mg/kg/d, intraperitoneally [i.p.]) for 3 days; groups III and IV received 200 and 400 mg/kg/d KV, respectively, orally for 14 days and groups V and VI were pretreated with 200 and 400 mg/kg/d KV, respectively, orally for 14 days followed by CP (50 mg/kg/d, i.p.) for 3 days., Results: CP treatment resulted in a significantly lower food consumption and body weight in rats. The lactate dehydrogenase and creatine kinase enzymes in cardiac tissues of rats treated with CP were significantly higher. In cardiac tissues, 3-day doses of CP resulted in significantly higher heart weight, cardiac troponin I, myeloperoxidase, malondialdehyde, hydrogen peroxide and lower superoxide dismutase, catalase, glutathione peroxidase activities, and reduced glutathione levels. Histological examination of cardiac tissues showed sign of necrosis of myocardium after CP treatment. However, administration of KV at 200 and 400 mg/kg for 14 days prior to CP treatment, increase food consumption, body weight, and attenuates the biochemical and histological changes induced by CP., Conclusions: These results revealed that KV attenuates CP-induced cardiotoxicity by inhibiting oxidative stress and preserving the activity of antioxidant enzymes.
- Published
- 2018
- Full Text
- View/download PDF
6. The role of electrocardiogram in the diagnosis of dextrocardia with mirror image atrial arrangement and ventricular position in a young adult Nigerian in Ile-Ife: a case report.
- Author
-
Ogunlade O, Ayoka AO, Akomolafe RO, Akinsomisoye OS, Irinoye AI, Ajao A, and Asafa MA
- Subjects
- Black People, Cardiomegaly diagnosis, Dextrocardia physiopathology, Diagnosis, Differential, Humans, Incidental Findings, Male, Nigeria, Situs Inversus physiopathology, Ultrasonography, Young Adult, Abdomen diagnostic imaging, Dextrocardia diagnosis, Electrocardiography, Situs Inversus diagnosis, Viscera diagnostic imaging
- Abstract
Introduction: Dextrocardia with situs inversus is a rare congenital disease. In patients with this condition, the heart is presented as a mirror image of itself with its apex pointing to the right. The pulmonary and abdominal anatomies are reversed. Dextrocardia with situs inversus occurs at birth but its diagnosis may be in adulthood. This case advances knowledge by graphically describing the unusual electrocardiographic features of dextrocardia in a young adult., Case Presentation: We report a case of a 22-year-old Nigerian man of Yoruba ethnicity who presented himself for preadmission medical test. He had a standard 12-lead electrocardiogram which revealed uncommon features: inversion of P waves in leads I, aVL and aVR; dominantly negative QRS waves in leads I, V1 to V6; reverse R wave progression in chest leads; low voltage in V4 to V6; extreme QRS axis; flattened T waves in V4 to V6 and aVR; and inverted T waves in lead I and aVL. An electrocardiogram diagnosis of dextrocardia was made. The differential diagnosis considered was right ventricular hypertrophy. A cardiovascular examination showed pulse rate of 70 beats per minute, blood pressure of 119/62mmHg, visible cardiac impulse at right precordium, apex beat was located at his fifth right intercostal space mid-clavicular line. A chest X-ray (posterior anterior view) including upper abdomen showed dextrocardia; his aortic arch was located on the right. His stomach bubble was located below his right hemidiaphragm. His trachea was slightly deviated to the left. The findings in his lung fields were not remarkable. Abdominopelvic ultrasonography showed that right-sided intra-abdominal organs (liver, gallbladder) were located on the left while left-sided organs (stomach, spleen) were located on the right. His abdominal aorta was on the right while his inferior vena cava was located on the left. A diagnosis of dextrocardia with situs inversus was made ultrasonographically., Conclusions: A properly interpreted electrocardiogram was useful in suspecting the diagnosis of dextrocardia with situs inversus. So, an analysis of a relatively simple and non-invasive diagnostic tool such as an electrocardiogram allows for suspicion of a cardiovascular anomaly in a setting of scarce diagnostic resources.
- Published
- 2015
- Full Text
- View/download PDF
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