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1. Prevalence of schizophrenia spectrum disorders among adults in the Lazio region, Italy: use of an algorithm based on health information systems

Author: A. Forastiere, S. Cascini, E. Calandrini, N. Agabiti, M. Davoli, and A. Bargagli
Subjects: Schizophrenia spectrum disorders, Health Information System, Epidemiology, Prevalence, Psychiatry, RC435-571
Abstract: Introduction Mental healthcare provision is undergoing substantial reconfiguration in many regions of the world. Such changes require a broad evidence-based approach incorporating epidemiological data and information of local needs. Objectives To estimate the prevalence of schizophrenia spectrum disorders (SSDs) in the Lazio region and its geographical distribution using the regional health information systems (HIS). Methods Cases of SSDs (15-64-year-old) were identified using an algorithm based on data from the hospital discharge registry [ICD IX CM: 295, 297, 298 (excl. 298.0)] and the ticket exemption database [code 044], between 2006 and 2019. Crude, and age- and gender-specific prevalence estimates on December 31, 2019, were calculated. To compare prevalence between different areas within the region, we calculated age- and gender-adjusted prevalence rates Results A total of 18,371 cases were identified. Crude prevalence rate was 4.29/1,000 (95% CI 4.29-4.30) and 5.93/1,000 (95% CI 5.92-5.949 for women and men, respectively. An increase in the prevalence rate by age was observed in both genders. The age- and gender-adjusted prevalence rate was 5.03/1,000 (95 % CI 4.96-5.10), with significant differences within the region, ranging from 4.25/1,000 in the province of Viterbo to 5.42/1,000 in the city of Rome and 6.02/1000 in the province of Frosinone. Conclusions Our results showed that the overall prevalence of SSDs among adults in the Lazio region is similar to estimates published in prior reviews, but an uneven regional geographical distribution was observed. While possible underestimation must be considered, HIS represents a valuable source of information useful for epidemiological surveillance and healthcare planning. Disclosure No significant relationships.
Published: 2022
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2. Engineered mesoporous silica-based nanoparticles as smart chemotherapy nanodevice for bortezomib administration

Author: M. De Santo, A. Giovinazzo, M. Fava, E. Mazzotta, I. E. De Napoli, M. Greco, A. Comandé, A. Nigro, P. Argurio, I. Perrotta, M. Davoli, A. Tagarelli, R. Elliani, T. Granato, G. Nicolini, A. Chiorazzi, S. Semperboni, E. Ballarini, C. Crocamo, G. Cavaletti, D. Lombardo, D. Sisci, C. Morelli, A. Leggio, L. Pasqua, De Santo, M, Giovinazzo, A, Fava, M, Mazzotta, E, De Napoli, I, Greco, M, Comande, A, Nigro, A, Argurio, P, Perrotta, I, Davoli, M, Tagarelli, A, Elliani, R, Granato, T, Nicolini, G, Chiorazzi, A, Semperboni, S, Ballarini, E, Crocamo, C, Cavaletti, G, Lombardo, D, Sisci, D, Morelli, C, Leggio, A, and Pasqua, L
Subjects: mesoporous silica, bortezomib, Materials Chemistry, General Materials Science
Abstract: Adverse reactions, toxicity, and poor compliance from patients still represent major challenges for conventional chemotherapy treatments. Localized drug delivery would ideally improve therapeutic efficacy, minimizing the side effects. An MSU-type mesoporous silica-based nanodevice (FOL-MSN-BTZ), able to selectively deliver the antineoplastic drug bortezomib (BTZ) to folate receptor over-expressing multiple myeloma (FR+ MM) cells is described. The receptor-specific ligand, folic acid, grafted on the external surface of the nanosystem, allows tumor recognition and cell internalization, while BTZ, mainly linked to the pore internal surface through a covalent pH-sensitive bond, is released in an acidic tumor environment. A detailed investigation showed that only the fine balancing of different functionalities of the nanodevice around the external and internal surfaces of MSN particles shows the absence of toxicity towards healthy cells in vitro and negligible BTZ-release at physiological pH, which are suitable features for applicative purposes in the engineering of therapies. After complete characterization in vitro, an accurate suspendability assessment, which considered the sedimentation process that reduces the particle amount and, consequently, drug content in the suspensions, allowed the development of an injectable formulation of FOL-MSN-BTZ that showed higher antitumor efficacy and an overall tendency to lower toxicity in a MM mice model compared to the conventional bortezomib chemotherapy.
Published: 2023

3. COVID-19 restrictions and NUTS-3 deprivation: multilevel approach in Italy during the second wave

Author: L Dei Bardi, A Acampora, M Di Martino, M Davoli, N Agabiti, and G Cesaroni
Subjects: Public Health, Environmental and Occupational Health
Abstract: Background To face the second COVID-19 wave, Italy implemented a tiered restriction system with different risk levels (yellow=low; orange=medium, red=high). It is unknown whether the effect of the tiers was equal among provinces with varying levels of socioeconomic deprivation (SED). At each restriction level, we analyzed the impact of the province's SED on the SARS-CoV-2 daily reproduction number (Rt). Methods We considered the Rt (Nov 2020-May 2021) as the dependent variable and the SED as the independent variable. The Rt was estimated using daily incidence data from the Civil Protection Department as the instantaneous Rt. The province SED was measured using the percentage of individuals whose yearly income was less than 10,000€ (2019 data from the Ministry of Economy and Finance). We used multilevel linear regression models with random intercepts stratified by restriction level to estimate the effect of the SED on Rt (β) and its Standard Error (SE). Our analyses adjusted the estimates for the number of days into the tier first and then for other covariates. Results We found different levels and trends of Rt by SED in every restriction. Days-adjusted models found a containing effect for the red and the orange tier, while the Rt had an increasing trend in yellow. Higher SED was associated with higher Rt: β was positive and significant in red (β = 0.004 SE = 0.001) and orange (β = 0.002 SE = 0.001) but not in the lowest tier (β = 0.001 SE = 0.001). We found a significant interaction between the number of days into the restriction and the SED in the complete models. Compared to less deprived, more deprived provinces had slower Rt reduction in the highest tier. However, they had steeper Rt reductions in orange and slower increasing trends in yellow. Conclusions The highest restriction had milder effects in more deprived provinces, while lower tiers were more effective. These results underline the importance of accounting for SED when implementing public health measures. Key messages • Area-level deprivation can modify the effects of public health measures. • Socioeconomic characteristics of the areas should be considered when implementing policies aimed to prevent the spread of epidemics.
Published: 2022
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4. Visual and Hearing Impairment Are Associated With Delirium in Hospitalized Patients: Results of a Multisite Prevalence Study

Author: Alessandro Morandi, Marco Inzitari, Cristina Udina, Neus Gual, Miriam Mota, Elena Tassistro, Anita Andreano, Antonio Cherubini, Simona Gentile, Enrico Mossello, Alessandra Marengoni, Anna Olivé, Francesc Riba, Domingo Ruiz, Elisabet de Jaime, Giuseppe Bellelli, A. Tarasconi, M. Sella, S. Auriemma, G. Paternò, G. Faggian, C. Lucarelli, N. De Grazia, C. Alberto, A. Margola, L. Porcella, I. Nardiello, E. Chimenti, M. Zeni, A. Giani, S. Famularo, E. Romairone, C. Minaglia, C. Ceccotti, G. Guerra, G. Mantovani, F. Monacelli, T. Candiani, A. Ballestrero, F. Santolini, M. Rosso, V. Bono, S. Sibilla, P. Dal Santo, M. Ceci, P. Barone, T. Schirinzi, A. Formenti, G. Nastasi, G. Isaia, D. Gonella, A. Battuello, S. Casson, D. Calvani, F. Boni, A. Ciaccio, R. Rosa, G. Sanna, S. Manfredini, L. Cortese, M. Rizzo, R. Prestano, A. Greco, M. Lauriola, G. Gelosa, V. Piras, M. Arena, D. Cosenza, A. Bellomo, M. LaMontagna, L. Gabbani, L. Lambertucci, S. Perego, G. Parati, G. Basile, V. Gallina, G. Pilone, C. Giudice, F. De, L. Pietrogrande, B. De, M. Mosca, I. Corazzin, P. Rossi, V. Nunziata, F. D'Amico, A. Grippa, S. Giardini, R. Barucci, A. Cossu, L. Fiorin, M. Distefano, M. Lunardelli, M. Brunori, I. Ruffini, E. Abraham, A. Varutti, E. Fabbro, A. Catalano, G. Martino, D. Leotta, A. Marchet, G. Dell'Aquila, A. Scrimieri, M. Davoli, M. Casella, A. Cartei, G. Polidori, D. Brischetto, S. Motta, R. Saponara, P. Perrone, G. Russo, D. Del, C. Car, T. Pirina, S. Franzoni, A. Cotroneo, F. Ghiggia, G. Volpi, C. Menichetti, M. Bo, A. Panico, P. Calogero, G. Corvalli, M. Mauri, E. Lupia, R. Manfredini, F. Fabbian, A. March, M. Pedrotti, M. Veronesi, E. Strocchi, C. Borghi, A. Bianchetti, A. Crucitti, V. DiFrancesco, G. Fontana, L. Bonanni, F. Barbone, C. Serrati, G. Ballardini, M. Simoncelli, G. Ceschia, C. Scarpa, R. Brugiolo, S. Fusco, T. Ciarambino, C. Biagini, E. Tonon, M. Porta, D. Venuti, M. DelSette, M. Poeta, G. Barbagallo, G. Trovato, A. Delitala, P. Arosio, F. Reggiani, G. Zuliani, B. Ortolani, E. Mussio, A. Girardi, A. Coin, G. Ruotolo, A. Castagna, M. Masina, R. Cimino, A. Pinciaroli, G. Tripodi, U. Cannistrà, F. Cassadonte, M. Vatrano, L. Scaglione, P. Fogliacco, C. Muzzuilini, F. Romano, A. Padovani, L. Rozzini, A. Cagnin, F. Fragiacomo, G. Desideri, E. Liberatore, A. Bruni, G. Orsitto, M. Franco, L. Bonfrate, M. Bonetto, N. Pizio, G. Magnani, G. Cecchetti, A. Longo, V. Bubba, L. Marinan, M. Cotelli, M. Turla, M. Sessa, L. Abruzzi, G. Castoldi, D. LoVetere, C. Musacchio, M. Novello, A. Cavarape, A. Bini, A. Leonardi, F. Seneci, W. Grimaldi, F. Fimognari, V. Bambara, A. Saitta, F. Corica, M. Braga, E. Ettorre, C. Camellini, G. Bellelli, G. Annoni, A. Marengoni, A. Crescenzo, G. Noro, R. Turco, M. Ponzetto, L. Giuseppe, B. Mazzei, G. Maiuri, D. Costaggiu, R. Damato, M. Formilan, G. Patrizia, M. Gallucci, M. Paragona, P. Bini, D. Modica, C. Abati, M. Clerici, I. Barbera, F. NigroImperiale, A. Manni, C. Votino, C. Castiglioni, M. Di, M. Degl'Innocenti, G. Moscatelli, S. Guerini, C. Casini, D. Dini, E. D'Imporzano, S. DeNotariis, F. Bonometti, C. Paolillo, A. Riccardi, A. Tiozzo, M. DiBari, S. Vanni, A. Scarpa, D. Zara, P. Ranieri, M. Alessandro, F. Di, D. Pezzoni, C. Platto, V. D'Ambrosio, C. Ivaldi, P. Milia, F. DeSalvo, C. Solaro, M. Strazzacappa, M. Cazzadori, S. Confente, M. Grasso, E. Troisi, V. Guerini, B. Bernardini, C. Corsini, S. Boffelli, A. Filippi, K. Delpin, B. Faraci, E. Bertoletti, M. Vannucci, F. Tesi, P. Crippa, A. Malighetti, D. Bettini, F. Maltese, G. Abruzzese, D. Cosimo, M. Azzini, M. Colombo, G. Procino, S. Fascendini, F. Barocco, P. Del, A. Mazzone, E. Riva, D. Dell'Acqua, M. Cottino, G. Vezzadini, S. Avanzi, C. Brambilla, S. Orini, F. Sgrilli, A. Mello, L. Lombardi, E. Muti, B. Dijk, S. Fenu, C. Pes, P. Gareri, M. Passamonte, R. Rigo, L. Locusta, L. Caser, G. Rosso, S. Cesarini, R. Cozzi, C. Santini, P. Carbone, I. Cazzaniga, R. Lovati, A. Cantoni, P. Ranzani, D. Barra, G. Pompilio, S. Dimori, S. Cernesi, C. Riccò, F. Piazzolla, E. Capittini, C. Rota, F. Gottardi, L. Merla, A. Barelli, A. Millul, G. De, G. Morrone, M. Bigolari, M. Macchi, F. Zambon, C. Pizzorni, G. DiCasaleto, G. Menculini, M. Marcacci, G. Catanese, D. Sprini, T. DiCasalet, M. Bocci, S. Borga, P. Caironi, C. Cat, E. Cingolani, L. Avalli, G. Greco, G. Citerio, L. Gandini, G. Cornara, R. Lerda, L. Brazzi, F. Simeone, M. Caciorgna, D. Alampi, S. Francesconi, E. Beck, B. Antonini, K. Vettoretto, M. Meggiolaro, E. Garofalo, S. Notaro, R. Varutti, F. Bassi, G. Mistraletti, A. Marino, R. Rona, E. Rondelli, I. Riva, A. Scapigliati, A. Cortegiani, F. Vitale, L. Pistidda, R. D'Andrea, L. Querci, P. Gnesin, M. Todeschini, M. Lugano, G. Castelli, M. Ortolani, A. Cotoia, S. Maggiore, L. DiTizio, R. Graziani, I. Testa, E. Ferretti, C. Castioni, F. Lombardi, R. Caserta, M. Pasqua, S. Simoncini, F. Baccarini, M. Rispoli, F. Grossi, L. Cancelliere, M. Carnelli, F. Puccini, G. Biancofiore, A. Siniscalchi, C. Laici, E. Mossello, M. Torrini, G. Pasetti, S. Palmese, R. Oggioni, V. Mangani, S. Pini, M. Martelli, E. Rigo, F. Zuccalà, A. Cherri, R. Spina, I. Calamai, N. Petrucci, A. Caicedo, F. Ferri, P. Gritti, N. Brienza, R. Fonnesu, M. Dessena, G. Fullin, D. Saggioro, Morandi, A, Inzitari, M, Udina, C, Gual, N, Mota, M, Tassistro, E, Andreano, A, Cherubini, A, Gentile, S, Mossello, E, Marengoni, A, Olivé, A, Riba, F, Ruiz, D, de Jaime, E, Bellelli, G, Alessandro Morandi, Marco Inzitari, Cristina Udina, Neus Gual, Miriam Mota, Elena Tassistro, Anita Andreano, Antonio Cherubini, Simona Gentile, Enrico Mossello, Alessandra Marengoni, Anna Olivé, Francesc Riba, Domingo Ruiz, Elisabet de Jaime, Giuseppe Bellelli, Italian Study Group of Delirium, Claudio Borghi, Morandi, Alessandro, Inzitari, Marco, Udina, Cristina, Gual, Neu, Mota, Miriam, Tassistro, Elena, Andreano, Anita, Cherubini, Antonio, Gentile, Simona, Mossello, Enrico, Marengoni, Alessandra, Olivé, Anna, Riba, Francesc, Ruiz, Domingo, de Jaime, Elisabet, Bellelli, Giuseppe, and A Tarasconi, M Sella, S Auriemma, G Paternò, G Faggian, C Lucarelli, N De Grazia, C Alberto, A Margola, L Porcella, I Nardiello, E Chimenti, M Zeni, A Giani, S Famularo, E Romairone, C Minaglia, C Ceccotti, G Guerra, G Mantovani, F Monacelli, C Minaglia, T Candiani, A Ballestrero, C Minaglia, F Santolini, C Minaglia, M Rosso, V Bono, S Sibilla, P Dal Santo, M Ceci, P Barone, T Schirinzi, A Formenti, G Nastasi, G Isaia, D Gonella, A Battuello, S Casson, D Calvani, F Boni, A Ciaccio, R Rosa, G Sanna, S Manfredini, L Cortese, M Rizzo, R Prestano, A Greco, M Lauriola, G Gelosa, V Piras, M Arena, D Cosenza, A Bellomo, M LaMontagna, L Gabbani, L Lambertucci, S Perego, G Parati, G Basile, V Gallina, G Pilone, C Giudice, F De, L Pietrogrande, B De, M Mosca, I Corazzin, P Rossi, V Nunziata, F D'Amico, A Grippa, S Giardini, R Barucci, A Cossu, L Fiorin, M Arena, M Distefano, M Lunardelli, M Brunori, I Ruffini, E Abraham, A Varutti, E Fabbro, A Catalano, G Martino, D Leotta, A Marchet, G Dell'Aquila, A Scrimieri, M Davoli, M Casella, A Cartei, G Polidori, G Basile, D Brischetto, S Motta, R Saponara, P Perrone, G Russo, D Del, C Car, T Pirina, S Franzoni, A Cotroneo, F Ghiggia, G Volpi, C Menichetti, M Bo, A Panico, P Calogero, G Corvalli, M Mauri, E Lupia, R Manfredini, F Fabbian, A March, M Pedrotti, M Veronesi, E Strocchi, C Borghi, A Bianchetti, A Crucitti, V DiFrancesco, G Fontana, L Bonanni, F Barbone, C Serrati, G Ballardini, M Simoncelli, G Ceschia, C Scarpa, R Brugiolo, S Fusco, T Ciarambino, C Biagini, E Tonon, M Porta, D Venuti, M DelSette, M Poeta, G Barbagallo, G Trovato, A Delitala, P Arosio, F Reggiani, G Zuliani, B Ortolani, E Mussio, A Girardi, A Coin, G Ruotolo, A Castagna, M Masina, R Cimino, A Pinciaroli, G Tripodi, U Cannistrà, F Cassadonte, M Vatrano, L Scaglione, P Fogliacco, C Muzzuilini, F Romano, A Padovani, L Rozzini, A Cagnin, F Fragiacomo, G Desideri, E Liberatore, A Bruni, G Orsitto, M Franco, L Bonfrate, M Bonetto, N Pizio, G Magnani, G Cecchetti, A Longo, V Bubba, L Marinan, M Cotelli, M Turla, M Brunori, M Sessa, L Abruzzi, G Castoldi, D LoVetere, C Musacchio, M Novello, A Cavarape, A Bini, A Leonardi, F Seneci, W Grimaldi, F Seneci, F Fimognari, V Bambara, A Saitta, F Corica, M Braga, E Ettorre, C Camellini, G Bellelli, G Annoni, A Marengoni, A Bruni, A Crescenzo, G Noro, R Turco, M Ponzetto, L Giuseppe, B Mazzei, G Maiuri, D Costaggiu, R Damato, E Fabbro, M Formilan, G Patrizia, M Gallucci, C Minaglia, M Paragona, P Bini, D Modica, C Abati, M Clerici, I Barbera, F NigroImperiale, A Manni, C Votino, C Castiglioni, M Di, M Degl'Innocenti, G Moscatelli, S Guerini, C Casini, D Dini, E D'Imporzano, S DeNotariis, F Bonometti, C Paolillo, A Riccardi, A Tiozzo, A Riccardi, C Paolillo, M DiBari, S Vanni, A Scarpa, D Zara, P Ranieri, M Alessandro, P Calogero, G Corvalli, F Di, D Pezzoni, C Platto, V D'Ambrosio, C Ivaldi, P Milia, F DeSalvo, C Solaro, M Strazzacappa, M Bo, A Panico, M Cazzadori, S Confente, M Bonetto, M Grasso, E Troisi, G Magnani, G Cecchetti, V Guerini, B Bernardini, C Corsini, S Boffelli, A Filippi, K Delpin, B Faraci, E Bertoletti, M Vannucci, F Tesi, P Crippa, A Malighetti, D Bettini, F Maltese, M Formilan, G Abruzzese, C Minaglia, D Cosimo, M Azzini, M Cazzadori, M Colombo, G Procino, S Fascendini, F Barocco, P Del, F D'Amico, A Grippa, A Mazzone, E Riva, D Dell'Acqua, M Cottino, G Vezzadini, S Avanzi, C Brambilla, S Orini, F Sgrilli, A Mello, L Lombardi, E Muti, B Dijk, S Fenu, C Pes, P Gareri, A Castagna, M Passamonte, F De, R Rigo, L Locusta, L Caser, G Rosso, S Cesarini, R Cozzi, C Santini, P Carbone, I Cazzaniga, R Lovati, A Cantoni, P Ranzani, D Barra, G Pompilio, S Dimori, S Cernesi, C Riccò, F Piazzolla, E Capittini, C Rota, F Gottardi, L Merla, A Barelli, A Millul, G De, G Morrone, M Bigolari, C Minaglia, M Macchi, F Zambon, F D'Amico, F D'Amico, C Pizzorni, G DiCasaleto, G Menculini, M Marcacci, G Catanese, D Sprini, T DiCasalet, M Bocci, S Borga, P Caironi, C Cat, E Cingolani, L Avalli, G Greco, G Citerio, L Gandini, G Cornara, R Lerda, L Brazzi, F Simeone, M Caciorgna, D Alampi, S Francesconi, E Beck, B Antonini, K Vettoretto, M Meggiolaro, E Garofalo, A Bruni, S Notaro, R Varutti, F Bassi, G Mistraletti, A Marino, R Rona, E Rondelli, I Riva, A Scapigliati, A Cortegiani, F Vitale, L Pistidda, R D'Andrea, L Querci, P Gnesin, M Todeschini, M Lugano, G Castelli, M Ortolani, A Cotoia, S Maggiore, L DiTizio, R Graziani, I Testa, E Ferretti, C Castioni, F Lombardi, R Caserta, M Pasqua, S Simoncini, F Baccarini, M Rispoli, F Grossi, L Cancelliere, M Carnelli, F Puccini, G Biancofiore, A Siniscalchi, C Laici, E Mossello, M Torrini, G Pasetti, S Palmese, R Oggioni, V Mangani, S Pini, M Martelli, E Rigo, F Zuccalà, A Cherri, R Spina, I Calamai, N Petrucci, A Caicedo, F Ferri, P Gritti, N Brienza, R Fonnesu, M Dessena, G Fullin, D Saggioro
Subjects: medicine.medical_specialty, Activities of daily living, Cross-sectional study, Hearing loss, medicine.medical_treatment, Visual impairment, Psychological intervention, visual impairment, Socio-culturale, behavioral disciplines and activities, Hearing impairment, delirium, older, sensory deficits, visual impairment, sensory deficit, Hearing impairment, 03 medical and health sciences, delirium, older, sensory deficits, 0302 clinical medicine, Risk Factors, Activities of Daily Living, mental disorders, medicine, Humans, Dementia, 030212 general & internal medicine, LS4_4, Hearing Loss, General Nursing, Rehabilitation, business.industry, Health Policy, General Medicine, medicine.disease, nervous system diseases, Cross-Sectional Studies, Italy, Emergency medicine, Delirium, Geriatrics and Gerontology, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: Objective: Sensory deficits are important risk factors for delirium but have been investigated in single-center studies and single clinical settings. This multicenter study aims to evaluate the association between hearing and visual impairment or bi-sensory impairment (visual and hearing impairment) and delirium. Design: Cross-sectional study nested in the 2017 "Delirium Day" project. Setting and participants: Patients 65 years and older admitted to acute hospital medical wards, emergency departments, rehabilitation wards, nursing homes, and hospices in Italy. Methods: Delirium was assessed with the 4AT (a short tool for delirium assessment) and sensory deficits with a clinical evaluation. We assessed the association between delirium, hearing and visual impairment in multivariable logistic regression models, adjusting for: Model 1, we included predisposing factors for delirium (ie, dementia, weight loss and autonomy in the activities of daily living); Model 2, we added to Model 1 variables, which could be considered precipitating factors for delirium (ie, psychoactive drugs and urinary catheters). Results: A total of 3038 patients were included; delirium prevalence was 25%. Patients with delirium had a higher prevalence of hearing impairment (30.5% vs 18%; P < .001), visual impairment (24.2% vs 15.7%; P < .01) and bi-sensory impairment (16.2% vs 7.5%) compared with those without delirium. In the multivariable logistic regression analysis, the presence of bi-sensory impairment was associated with delirium in Model 1 [odds ratio (OR) 1.5, confidence interval (CI) 1.2-2.1; P = .00] and in Model 2 (OR 1.4; CI 1.1-1.9; P = .02), whereas the presence of visual and hearing impairment alone was not associated with delirium either in Model 1 (OR 0.8; CI 0.6-1.2, P = .36; OR 1.1; CI 0.8-1.4; P = .42) or in Model 2 (OR 0.8, CI 0.6-1.2, P = .27; OR 1.1, CI 0.8-1.4, P = .63). Conclusions and implications: Our findings support the importance of routine screening and specific interventions by a multidisciplinary team to implement optimal management of sensory impairments and hence prevention and the management of the patients with delirium.
Published: 2021

5. Audit and feedback strategies: study protocol and preliminary results from the EASY-NET project

Author: N Agabiti, R Grilli, F Valent, G Ciccone, G Marchesini Reggiani, G Marenzi, C Di Carlo, P Bramanti, and M Davoli
Subjects: Public Health, Environmental and Occupational Health
Abstract: Background In Italy there is evidence of a large variability in health care services and health outcomes. This multi-regional project is funded on Ministry of Health and Health Regional Authorities (code NET-2016-02364191). The aims are: 1) To test the effectiveness of Audit and Feedback (A&F) interventions in improving health professional practices and patients' outcomes in different settings using both a quantitative and a qualitative approach. 2) To examine factors that may explain variations in the effectiveness of A&F. 3) To evaluate the impact of A&F in reducing avoidable differences in access to effective health care interventions in socioeconomically disadvantaged populations. Methods In the 7 participating Regions (about 33 million inhabitants) experimental study designs have been implemented in different clinical areas (e.g. before-after controlled study, cluster randomized trial): in Lazio emergency care and chronic diseases care, in Friuli Venezia Giulia emergency care, in Piemonte oncology care, in Emilia Romagna chronic disease care, in Lombardia cardiovascular care, in Calabria deliveries and maternal health, in Sicilia emergency care. The effectiveness of different types of A&F are compared in term of outcomes using health information system databases. Results Preliminary results show large heterogeneity in developing and conducting A&F, in term of team project composition, type of intervention, clinicians' behavior to be changed, outcomes indicators, professionals involved, structure and timing of data reporting, actions to be implemented after the intervention. Limited awareness and interest of clinicians in A&F interventions was found. Conclusions The project represents a unique opportunity to explore how A&F interventions could be better designed. Different A&F strategies will be compared in term of clinical outcomes. The identification of barriers/facilitating factors will supply knowledge on mechanisms and tools to enhance A&F effectiveness. Key messages The project supports providers in reducing gap between knowledge and practice. The project promotes culture of interprofessional collaboration as a key point for high quality care.
Published: 2021
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6. Does air pollution modify the effect of heat on mortality during the warm season? Results from a multi-country study

Author: M. Davoli, M. Scortichini, M. Stafoggia, Paola Michelozzi, and de’Donato F
Subjects: Air pollution, medicine, General Earth and Planetary Sciences, Environmental science, Atmospheric sciences, medicine.disease_cause, Warm season, General Environmental Science, Multi country
Published: 2020
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7. Elemental constituents of particulate matter and pregnancy outcomes

Author: G, Cesaroni, primary, F, Cerza, additional, M, Davoli, additional, and P, Michelozzi, additional
Published: 2019
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8. Short-Term Effects of Temperature on Peadiatric Hospital Admissions for Respiratory Diseases in Italy

Author: M, Scortichini, primary, F, de’ Donato, additional, C, Gariazzo, additional, M, Stafoggia, additional, M, Davoli, additional, G, Viegi, additional, S, La Grutta, additional, S, Fasola, additional, S, Maio, additional, and P, Michelozzi, additional
Published: 2019
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9. Future attributable deaths of heatwaves in Italian cities using high resolution climate change scenarios

Author: F, de’Donato, primary, M, Scortichini, additional, V, Villani, additional, P, Mercogliano, additional, M, De Sario, additional, M, Davoli, additional, and P, Michelozzi, additional
Published: 2019
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10. Nationwide analysis on the effect of outdoor temperature on occupational injuries in Italy.

Author: M, Scortichini, primary, M, Bonafede, additional, A, Leva, additional, F, de’ Donato, additional, P, Michelozzi, additional, M, Davoli, additional, M, Stafoggia, additional, G, Viegi, additional, C, Gariazzo, additional, and A, Marinaccio, additional
Published: 2019
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11. Low concentration of cadmium, nickel, and lead in human body and cardio-metabolic diseases in the industrial area of Civitavecchia

Author: L, Bauleo, primary, F, Forastiere, additional, F, Ruggieri, additional, B, Bocca, additional, A, Alimonti, additional, M, Davoli, additional, P, Michelozzi, additional, and C, Ancona, additional
Published: 2019
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12. The body of evidence on pollen-related asthma exacerbations in children in the climate change era

Author: M, De Sario, primary, E, Falcone, additional, F, de’Donato, additional, M, Scortichini, additional, M, D’Ovidio, additional, M, Davoli, additional, and P, Michelozzi, additional
Published: 2019
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13. Long-term exposure to ultrafine particles and cause-specific mortality in the Rome Longitudinal Study

Author: G, Cesaroni, primary, C, Ancona, additional, G, Cattani, additional, A, Gaeta, additional, C, Badaloni, additional, P, Michelozzi, additional, M, Davoli, additional, F, Forastiere, additional, and M, Stafoggia, additional
Published: 2019
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14. A nationwide study of particulate matter and daily hospitalizations for respiratory diseases in Italy.

Author: M, Renzi, primary, P, Michelozzi, additional, C, Gariazzo, additional, S, Maio, additional, M, Davoli, additional, F, Forastiere, additional, G, Viegi, additional, and M, Stafoggia, additional
Published: 2019
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15. Short-term effects of heat and cold on cause-specific hospital admissions at municipal level in Italy – a national approach

Author: M, Scortichini, primary, F, de’ Donato, additional, P, Michelozzi, additional, S, Maio, additional, S, Fasola, additional, M, Davoli, additional, C, Gariazzo, additional, G, Viegi, additional, and M, Stafoggia, additional
Published: 2019
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16. Air pollution exposure and respiratory symptoms between 12 and 24 months

Author: F, Asta, primary, D, Porta, additional, M, Stafoggia, additional, F, Rusconi, additional, L, Gagliardi, additional, C, Pizzi, additional, L, Ronfani, additional, S, Brescianini, additional, M, Davoli, additional, and P, Michelozzi, additional
Published: 2019
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17. Short-term association between daily PM2.5 and PM10 concentrations and cardiovascular admissions in Italy – a national approach

Author: M, Stafoggia, primary, M, Renzi, additional, C, Gariazzo, additional, S, Fasola, additional, P, Michelozzi, additional, F, Forastiere, additional, M, Davoli, additional, and G, Viegi, additional
Published: 2019
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18. Greenness and cognitive development at age 7 years in a Rome birth cohort

Author: F, Asta, primary, D, Porta, additional, M, De Sario, additional, G, Cesaroni, additional, M, Davoli, additional, and P, Michelozzi, additional
Published: 2019
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19. Association between air pollution and venous thromboembolism

Author: A, Solimini, primary, M, Renzi, additional, M, Stafoggia, additional, P, Michelozzi, additional, F, Forastiere, additional, and M, Davoli, additional
Published: 2019
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20. P6250Cardiovascular risk factors among 94,473 acute coronary syndrome patients in Europe

Author: Danilo Fusco, M. Davoli, S. Huo Yung Kai, Irene R. Dégano, Ana Azevedo, Dimitrios Farmakis, Jean Ferrières, A. Malmivaara, Inge Kirchberger, Marina Torre, and Jaume Marrugat
Subjects: Acute coronary syndrome, medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, medicine.disease, business
Published: 2017
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21. DIALYSIS VASCULAR ACCESS

Author: N. Fontsere, G. Mestres, M. Burrel, M. Barrufet, X. Montana, M. Arias, R. Ojeda, F. Maduell, J. M. Campistol, P. Nagaraja, D. Rees, T. Husein, J. Chess, C.-C. Lin, W.-C. Yang, M. Khosravi, H. Kandil, J. Cross, S. Hopkins, S. Collier, D. Lopes, S. Pereira, A. M. Gomes, A. Ventura, V. Martins, J. Seabra, T. C. Rothuizen, F. Damanik, M. J. T. Visser, T. Lavrijsen, M. A. J. Cox, L. Moroni, T. J. Rabelink, J. I. Rotmans, C. Cardozo, J. Donate, A. Soriano, M. Muros, M. Pons, J. Mensa, J. F. Navarro-Gonzalez, A. Wijewardane, A. Murley, S. Powers, C. Allen, J. Baharani, T. Wilmink, M. Esenturk, M. Zengin, M. Dal, N. Tahtal, K. Shibata, T. Shinzato, H. Satta, M. Nishihara, N. Koguchi, T. Kuji, S. Kawata, T. Kaneda, G. Yasuda, J. Scrivano, L. Pettorini, T. Rutigliano, G. M. Ciavarella, L. De Biase, G. Punzo, P. Mene, N. Pirozzi, W. El Haggan, K. Belazrague, S. Ehoussou, V. Foucher, M. El Salhy, G. Ouellet, J. Davis, P. Caron, M. Leblanc, F. Romitelli, L. Fazzari, G. Ortu, E. Di Stasio, G. Loizzo, S. M. Vigano, G. Bacchini, E. Rocchi, V. Sala, G. Pontoriero, K. Letachowicz, T. Go biowski, M. Kusztal, W. Letachowicz, W. Weyde, M. Klinger, L. Hollingsworth, R. Roca-Tey, R. Samon, O. Ibrik, A. Roda, J. C. Gonzalez-Oliva, R. Martinez-Cercos, J. Viladoms, C. J. Renaud, E. K. Lim, T. Y. Seow, H. S. Teh, J. Tosic, A. Jankovic, P. Djuric, V. Radovic Maslarevic, J. Popovic, N. Dimkovic, A. Kazantzi, K. Trigka, F. Buono, S. Laurino, G. Toriello, R. Di Luccio, A. Galise, Y. O. Kim, S. A. Yoon, Y. S. Kim, S. J. Choi, J. W. Min, M. A. Cheong, M. Asano, K. Oguchi, A. Saito, Y. Onishi, Y. Yamamoto, S. Fukuhara, T. Akiba, T. Akizawa, K. Kurokawa, M. Guedes Marques, J. Ibeas, P. Maia, P. Ponce, K. Y. Chang, H. S. Park, H. W. Kim, B. S. Choi, C. W. Park, C. W. Yang, D. C. Jin, E. Likaj, S. Seferi, G. Caco, E. Petrela, M. Barbullushi, A. Idrizi, N. Thereska, C. Lomonte, F. Casucci, P. Libutti, P. Lisi, C. Basile, P. Ancarani, G. Valsuani, L. Cavallo, D. Parodi, C. Lorusso, C. Renaud, B. C. Lai, S. Tho, L. Yeoh, C. Botelho, A. Yankovoy, S. Alexandr, A. Smoliacov, V. Stepanov, C. Parker, P. Davies, S. Taylor, A. Mikhail, J. Gubensek, V. Persic, B. Vajdic, R. Ponikvar, J. Buturovic-Ponikvar, U. Hadimeri, A. V. Warme, B. Stegmayr, S. Suvakov, T. Damjanovic, S. Bajcetic, V. Radovic-Maslarevic, T. Simic, M. Rroji, H. L. Chua, H. Kanda, S. L. See, N. C. Liew, K. Tsuchida, T. Tomo, M. Fukasawa, S. Kawashima, J. Minakuchi, V. Thanaraj, A. Dhaygude, K. Ikeda, G. Forneris, P. Cecere, M. Pozzato, M. Trogolo, A. Vallero, P. Mesiano, D. Roccatello, L. Keskin, J. R. Casey, C. S. Hanson, W. C. Winkelmayer, J. Craig, S. Palmer, G. Strippoli, A. Tong, D. Ferrara, S. Scamarda, L. Bernardino, L. Amico, M. C. Lorito, f. Incalcaterra, L. Visconti, G. Visconti, F. Valenza, F. D'Amato, A. Di Napoli, L. Tazza, S. Chicca, E. Lapucci, P. Silvestri, D. Di Lallo, P. Michelozzi, and M. Davoli
Subjects: Transplantation, medicine.medical_specialty, Nephrology, business.industry, Vascular access, medicine, Intensive care medicine, Dialysis (biochemistry), business
Published: 2014
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22. Short-Term Effects of Temperature on Peadiatric Hospital Admissions for Respiratory Diseases in Italy

Author: Matteo Scortichini, Michelozzi P, Gariazzo C, Stafoggia M, M. Davoli, La S, de’ F, Maio S, Viegi G, and Salvatore Fasola
Subjects: Global and Planetary Change, medicine.medical_specialty, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Emergency medicine, Public Health, Environmental and Occupational Health, medicine, Respiratory system, business, Pollution, Term (time)
Published: 2019
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23. Short-term association between daily PM2.5 and PM10 concentrations and cardiovascular admissions in Italy – a national approach

Author: Gariazzo C, Salvatore Fasola, Viegi G, Michelozzi P, Stafoggia M, M. Davoli, Renzi M, and Forastiere F
Subjects: Global and Planetary Change, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Environmental health, Public Health, Environmental and Occupational Health, Medicine, business, Association (psychology), Pollution, Term (time)
Published: 2019
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24. Percutaneous coronary intervention reduces mortality in myocardial infarction patients with comorbidities: Implications for elderly patients with diabetes or kidney disease

Author: Dégano, I.R. Subirana, I. Fusco, D. Tavazzi, L. Kirchberger, I. Farmakis, D. Ferrières, J. Azevedo, A. Torre, M. Garel, P. Brosa, M. Davoli, M. Meisinger, C. Bongard, V. Araújo, C. Lekakis, J. Francès, A. Castell, C. Elosua, R. Marrugat, J. on behalf of the EUROTRACS investigators
Abstract: Background Percutaneous coronary intervention (PCI) reduces mortality in most myocardial infarction (MI) patients but the effect on elderly patients with comorbidities is unclear. Our aim was to analyse the effect of PCI on in-hospital mortality of MI patients, by age, sex, ST elevation on presentation, diabetes mellitus (DM) and chronic kidney disease (CKD). Methods Cohort study of 79,791 MI patients admitted at European hospitals during 2000–2014. The effect of PCI on in-hospital mortality was analysed by age group (18–74, ≥ 75 years), sex, presence of ST elevation, DM and CKD, using propensity score matching. The number needed to treat (NNT) to prevent a fatal event was calculated. Sensitivity analyses were conducted. Results PCI was associated with lower in-hospital mortality in ST and non-ST elevation MI (STEMI and NSTEMI) patients. The effect was stronger in men [Odds ratio (95% confidence interval) 0.30 (0.25–0.35)] than in women [0.46 (0.39–0.54)] aged ≥ 75 years, and in NSTEMI [0.22 (0.17–0.28)] than in STEMI patients [0.40 (0.31–0.5)] aged < 75 years. PCI reduced in-hospital mortality risk in patients with and without DM or CKD (54–72% and 52–73% reduction in DM and CKD patients, respectively). NNT was lower in patients with than without CKD [≥ 75 years: STEMI = 6(5–8) vs 9(8–10); NSTEMI = 10(8–13) vs 16(14–20)]. Sensitivity analyses such as exclusion of hospital stays < 2 days yielded similar results. Conclusions PCI decreased in-hospital mortality in MI patients regardless of age, sex, and presence of ST elevation, DM and CKD. This supports the recommendation for PCI in elderly patients with DM or CKD. © 2017 The Authors
Published: 2017

25. Abstracts

Author: O. Barthelemy, J. Silvain, D. Brieger, A. Bellemain-Appaix, G. Cayla, F. Beygui, R. Lancar, J. P. Collet, A. Mercadier, G. Montalescot, K. S. Cha, Y. H. Nam, J. H. Kim, S. Y. Park, T. H. Park, M. H. Kim, Y. D. Kim, H. C. Lee, M. S. Ahn, T. J. Hong, R. Blanco, F. Blanco, J. Szarfer, A. Garcia Escudero, G. Gigena, J. Gagliardi, A. Rodriguez, R. Sarmiento, S. Affatatto, M. Riccitelli, A. Petris, M. D. Datcu, C. Pop, M. Radoi, C. Arsenescu-Georgescu, I. Petrescu, L. Petrescu, L. Serban, E. Nechita, G. Tatu-Chitoiu, M. Dorobantu, I. Benedek, E. Craiu, C. Sinescu, D. D. Ionescu, C. Ginghina, B. Minescu, A. Izzo, P. Mantovani, L. Tomasi, L. Dall'oglio, S. Bonatti, R. Rosiello, M. Romano, F. Agostini, R. Zanini, Z. Y. Zhao, Y. J. Wu, J. J. Li, Y. J. Yany, H. Y. Qian, Y. D. Tang, A. T. Timoteo, A. Toste, A. Lousinha, R. Ramos, J. A. Oliveira, M. L. Ferreira, R. C. Ferreira, C. Cabades, J. L. Diez Gil, P. Aguar, D. Sanmiguel, A. Lopez-March, R. Marmol, L. Guerra, V. Girbes, J. Ferrando, A. Rincon De Arellano, L. Patricio, M. Blondal, T. Ainla, T. Marandi, J. Eha, M. M. Oliveira, M. N. Silva, P. S. Cunha, J. Feliciano, S. Silva, J. Kanovsky, P. Kala, J. Parenica, M. Poloczek, K. Prymusova, L. Kubkova, J. Spinar, D. Olinic, C. Homorodean, M. Ober, M. Olinic, C. Andrioaia, A. Condac, M. Masmoudi, B. Berdaoui, S. Labidi, C. Tapia Ballesteros, C. Hernandez Luis, M. G. Sandin, J. M. Vegas, R. Andion, N. Martinez, I. A. Gonzalez, M. Alvarado, I. J. Amat, J. A. San Roman, M. J. Garcia Gonzalez, E. Arroyo Ucar, C. Hernandez Garcia, M. Dorta Martin, F. Marrero Rodriguez, R. Dragu, M. Kapeliovich, H. Hammerman, D. Silva, N. Cortez-Dias, C. Jorge, J. Silva Marques, P. Carilho Ferreira, S. Robalo Martins, M. Almeida Ribeiro, C. Calisto, M. Fiuza, M. G. Lopes, P. Milicevic, M. Panic, I. Stankovic, D. Milicevic, T. Kalezic, S. Kafedzic, I. Ilic, M. Cerovic, B. Putnikovic, A. Neskovic, D. Rott, D. Leibowitz, Z. Monhart, J. Reissigova, H. Grunfeldova, P. Jansky, B. Valente, I. Villanueva Benito, I. Solla, E. Paredes, O. Diaz Castro, F. Calvo, J. A. Baz, A. Iniguez, A. Aleksova, R. Gerloni, R. Belfiore, C. Carriere, G. Barbati, E. Fabris, F. Possa, D. Nait, M. Milo, G. Sinagra, N. Marques, J. Mimoso, V. Gomes, R. M. Agra Bermejo, E. A. A. Emad Abu Assi, S. R. R. Sergio Raposeiras Roubin, P. C. G. Pilar Cabanas Grandio, C. P. G. Carlos Pena Gil, J. M. G. A. Jose Maria Garcia Acuna, J. R. G. J. Jose Ramon Gonzalez Juanatey, M. J. Daly, P. Scott, C. G. Owens, A. Tomlin, B. Smith, A. A. J. Adgey, L. R. Alvarez-Contreras, U. Juarez, A. Altamirano, A. Arias, A. Alvarez-San Gabriel, H. Gonzalez-Pacheco, C. Martinez-Sanchez, M. Rahnavardi, M. Keshtkar-Jahromi, H. Vakili, S. Gholamin, S. M. Razavi, T. Gilis-Januszewski, K.- P. Mellwig, M. Wiemer, J. Gilis-Januszewski, A. Peterschroeder, J. Koerfer, D. Horstkotte, M. Vrsalovic, B. Getaldic, N. Vrkic, H. Pintaric, S. Khan, B. Wasan, L. Moretti, P. Grossi, S. Silenzi, M. Testa, L. Candelori, L. N. Clementi, M. Forlini, L. Lando, M. L. Pezzuoli, P. Corradetti, G. Leurent, P. Y. Pennec, E. Filippi, B. Moquet, J. P. Hacot, P. Druelles, A. Rialan, G. Rouault, I. Coudert, H. Le Breton, S. Gevaert, F. Tromp, E. Vandecasteele, F. De Somer, Y. Van Belleghem, S. Bouchez, F. Martens, I. Herck, M. De Pauw, O. Ludka, M. Sepsi, R. Miklik, L. Dusek, D. Tomcikova, J. M. Garcia-Acuna, P. Aguiar-Souto, S. Raposeiras Roubin, R. Agra-Bermejo, M. Jacquet, E. Abu-Assi, J. R. Gonzalez-Juanatey, A. Ibatov, R. Labrova, R. Karlik, P. Lokaj, Q. She, S. B. Deng, S. H. Huang, L. J. Gu, J. I. A. N. Rong, Z. K. Wu, Y. Li, J. Zhang, L. Parascan, A. Campanile, L. Spinelli, G. Santulli, M. Ciccarelli, S. De Gennaro, E. Assante Di Panzillo, B. Trimarco, G. Iaccarino, E. Bobescu, G. Datcu, D. Dobreanu, B. Doka, J.- C. Charniot, C. Cosson, J. P. Albertini, R. Bittar, P. Giral, C. Cherfils, E. Guillerm, D. Bonnefont-Rousselot, A. Rusali, L. Cojocaru, I. Parepa, T. Koizumi, S. Iida, J. Sato, T. Kikutani, T. 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Alvarado Montes De Oca, V. Dytrych, T. Kovarnik, O. Smid, A. Kral, A. G. Aroutunov, S. Intwala, I. Jegere, H. S. H. Shaalan, Z. Pagava, R. Agladze, R. Shakarishvili, N. Sharashidze, L. Gujejiani, G. Saatashvili, T. Z. Katova, V. Kostova, Y. Simova, S. Vukotic, S. Rafajlovski, R. Romanovic, N. Antonijevic, B. Gligic, M. Hutyra, T. Skala, D. Horak, D. Vindis, M. Taborsky, A. Contine, M. Del Pinto, F. Angeli, P. Verdecchia, F. Borgognoni, E. Grikstaite, P. Pantano, G. Ambrosio, C. Cavallini, C. Bonanad, J. Sanchis, V. Bodi, J. Nunez, X. Bosch, M. Heras, M. Pellicer, A. Llacer, L. Adao, M. Oliveira, H. Goncalves, J. Primo, V. Gama, C. Lombardi, M. Metra, S. Bugatti, E. Pasotti, F. Quinzani, M. Adamo, C. Villa, R. Rovetta, A. Manerba, M. Mariani, A. Dushpanova, M. Baroni, E. Cerone, A. Nardelli, J. Gianetti, S. Berti, F. Feliciano, R. Soares, S. Santos, A. Kruger, D. Vondrakova, J. Herget, C. Navarro, N. A. Cromie, J. A. A. Adgey, D. Caeiro Pereira, P. Braga, R. Fontes Carvalho, A. Rodrigues, M. Goncalves, L. Simoes, and K. V. Borisov
Subjects: Cardiology and Cardiovascular Medicine
Published: 2010
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26. Desert Dust Outbreaks in Southern Europe: Contribution to Daily PM10 Concentrations and Short-Term Associations with Mortality and Hospital Admissions

Author: Stafoggia, Massimo Zauli-Sajani, Stefano Pey, Jorge Samoli, Evangelia Alessandrini, Ester Basagana, Xavier Cernigliaro, Achille Chiusolo, Monica Demaria, Moreno Diaz, Julio and Faustini, Annunziata Katsouyanni, Klea Kelessis, Apostolos G. and Linares, Cristina Marchesi, Stefano Medina, Sylvia and Pandolfi, Paolo Perez, Noemi Querol, Xavier Randi, Giorgia and Ranzi, Andrea Tobias, Aurelio Forastiere, Francesco and Alessandrini, E. Angelini, P. Berti, G. Bisanti, L. and Cadum, E. Catrambone, M. Chiusolo, M. Davoli, M. de' Donato, F. Demaria, M. Gandini, M. Grosa, M. Faustini, A. Ferrari, S. Forastiere, F. Pandolfi, P. Pelosini, R. and Perrino, C. Pietrodangelo, A. Pizzi, L. Poluzzi, V. and Priod, G. Randi, G. Ranzi, A. Rowinski, M. Scarinzi, C. and Stafoggia, M. Stivanello, E. Zauli-Sajani, S. and Dimakopoulou, K. Elefteriadis, K. Katsouyanni, K. Kelessis, A. Maggos, T. Michalopoulos, N. Pateraki, S. Petrakakis, M. Rodopoulou, S. Samoli, E. Sypsa, V. Agis, D. and Alguacil, J. Artinano, B. Barrera-Gomez, J. Basagana, X. and de la Rosa, J. Diaz, J. Fernandez, R. Jacquemin, B. and Karanasiou, A. Linares, C. Ostro, B. Perez, N. Pey, J. and Querol, X. Salvador, Pedro Sanchez, A. M. Sunyer, J. and Tobias, A. Bidondo, M. Declercq, C. Le Tertre, A. and Lozano, P. Medina, S. Pascal, L. Pascal, M. and MED-PARTICLES Study Grp
Subjects: fungi, complex mixtures, geographic locations, respiratory tract diseases
Abstract: BACKGROUND: Evidence on the association between short-term exposure to desert dust and health outcomes is controversial. OBJECTIVES: We aimed to estimate the short-term effects of particulate matter 0 mu g/m(3)). Most episodes occurred in spring-summer, with increasing gradient of both frequency and intensity north-south and west-east of the Mediterranean basin. We found significant associations of both PM10 concentrations with mortality. Increases of 10 mu g/m(3) in non-desert and desert PM10 (lag 0-1 days) were associated with increases in natural mortality of 0.55% (95% CI: 0.24, 0.87%) and 0.65% (95% CI: 0.24, 1.06%), respectively. Similar associations were estimated for cardio-respiratory mortality and hospital admissions. CONCLUSIONS: PM10 originating from the desert was positively associated with mortality and hospitalizations in Southern Europe. Policy measures should aim at reducing population exposure to anthropogenic airborne particles even in areas with large contribution from desert dust advections.
Published: 2016

27. The risks of acute exposure to black carbon in Southern Europe: Results from the med-particles project

Author: Ostro, B. Tobias, A. Karanasiou, A. Samoli, E. Querol, X. Rodopoulou, S. Basagaña, X. Eleftheriadis, K. Diapouli, E. Vratolis, S. Jacquemin, B. Katsouyanni, K. Sunyer, J. Forastiere, F. Stafoggia, M. Alessandrini, E. Angelini, P. Berti, G. Bisanti, L. Cadum, E. Catrambone, M. Chiusolo, M. Davoli, M. De'Donato, F. Demaria, M. Gandini, M. Grosa, M. Faustini, A. Ferrari, S. F, F. Pandolfi, P. Pelosini, R. Perrino, C. Pietrodangelo, A. Pizzi, L. Poluzzi, V. Randi, G. Ranzi, A. Rowinski, M. Scarinzi, C. S, M. Stivanello, E. ZauliSajani, S. Dimakopoulou, K. E, K. K, K. Kelessis, A.G. Maggos, T. Mihalopoulos, N. Pateraki, S. Petrakakis, M. R, S. S, E. Sypsa, V. Agis, D. Artiñano, B. BarreraGómez, J. B, X. De La Rosa, J. Diaz, J. Fernandez, R. J, B. K, A. Linares, C. O, B. Perez, N. Pey, J. Q, X. Sanchez, A.M. S, J. T, A. Bidondo, M. Declercq, C. Le Tertre, A. Lozano, P. Medina, S. Pascal, L. Pascal, M. MED-PARTICLES Study Group
Abstract: Objectives: While several studies have reported associations of daily exposures to PM2.5 (particles less than 2.5 μm) with mortality, few studies have examined the impact of its constituents such as black carbon (BC), which is also a significant contributor to global climate change. Methods: We assessed the association between daily concentrations of BC and total, cardiovascular and respiratory mortality in two southern Mediterranean cities. Daily averages of BC were collected for 2 years in Barcelona, Spain and Athens, Greece. We used case-crossover analysis and examined single and cumulative lags up to 3 days. Results: We observed associations between BC and all mortality measures. For a 3-day moving average, cardiovascular mortality increased by 4.5% (95% CI 0.7 to 8.5) and 2.0% (95% CI 0 to 4.0) for an interquartile change in BC in Athens and Barcelona, respectively. Considerably higher effects for respiratory mortality and for those above age 65 were observed. In addition, BC exhibited much greater toxicity per microgram than generic PM2.5. Conclusions: Our findings suggest that BC, derived in western industrialised nations primarily from diesel engines and biomass burning, poses a significant burden to public health, particularly in European cities with high-traffic density.
Published: 2015

28. Short-term effects of particulate matter constituents on daily hospitalizations and mortality in five South-European cities: Results from the MED-PARTICLES project

Author: Basagaña, X. Jacquemin, B. Karanasiou, A. Ostro, B. Querol, X. Agis, D. Alessandrini, E. Alguacil, J. Artiñano, B. Catrambone, M. De La Rosa, J.D. Díaz, J. Faustini, A. Ferrari, S. Forastiere, F. Katsouyanni, K. Linares, C. Perrino, C. Ranzi, A. Ricciardelli, I. Samoli, E. Zauli-Sajani, S. Sunyer, J. Stafoggia, M. Angelini, P. Berti, G. Bisanti, L. Cadum, E. Chiusolo, M. Davoli, M. De'Donato, F. Demaria, M. Gandini, M. Grosa, M. Pandolfi, P. Pelosini, R. Pietrodangelo, A. Pizzi, L. Poluzzi, V. Priod, G. Randi, G. Rowinski, M. Scarinzi, C. Stivanello, E. Dimakopoulou, K. Elefteriadis, K. Kelessis, A. Maggos, T. Michalopoulos, N. Pateraki, S. Petrakakis, M. Rodopoulou, S. Sypsa, V. Barrera-Gómez, J. Fernandez, R. Perez, N. Pey, J. Salvador, P. Sanchez, A.M. Tobias, A. Bidondo, M. Declercq, C. Le Tertre, A. Lozano, P. Medina, S. Pascal, L. Pascal, M. MED-PARTICLES Study group
Abstract: Background: Few recent studies examined acute effects on health of individual chemical species in the particulate matter (PM) mixture, and most of them have been conducted in North America. Studies in Southern Europe are scarce. The aim of this study is to examine the relationship between particulate matter constituents and daily hospital admissions and mortality in five cities in Southern Europe. Methods: The study included five cities in Southern Europe, three cities in Spain: Barcelona (2003-2010), Madrid (2007-2008) and Huelva (2003-2010); and two cities in Italy: Rome (2005-2007) and Bologna (2011-2013). A case-crossover design was used to link cardiovascular and respiratory hospital admissions and total, cardiovascular and respiratory mortality with a pre-defined list of 16 PM10and PM2.5constituents. Lags 0 to 2 were examined. City-specific results were combined by random-effects meta-analysis. Results: Most of the elements studied, namely EC, SO4 2-, SiO2,Ca, Fe, Zn, Cu, Ti, Mn, V and Ni, showed increased percent changes in cardiovascular and/or respiratory hospitalizations, mainly at lags 0 and 1. The percent increase by one interquartile range (IQR) change ranged from 0.69% to 3.29%. After adjustment for total PM levels, only associations for Mn, Zn and Ni remained significant. For mortality, although positive associations were identified (Fe and Ti for total mortality; EC and Mg for cardiovascular mortality; and NO3 -for respiratory mortality) the patterns were less clear. Conclusions: The associations found in this study reflect that several PM constituents, originating from different sources, may drive previously reported results between PM and hospital admissions in the Mediterranean area. © 2014 Elsevier Ltd.
Published: 2015

29. Short-term effects of particulate matter on mortality during forest fires in Southern Europe: Results of the MED-PARTICLES project

Author: Faustini, A. Alessandrini, E.R. Pey, J. Perez, N. Samoli, E. Querol, X. Cadum, E. Perrino, C. Ostro, B. Ranzi, A. Sunyer, J. Stafoggia, M. Forastiere, F. Angelini, P. Berti, G. Bisanti, L. Catrambone, M. Chiusolo, M. Davoli, M. De'donato, F. Demaria, M. Gandini, M. Grosa, M. Ferrari, S. Pandolfi, P. Pelosini, R. Pietrodangelo, A. Pizzi, L. Poluzzi, V. Priod, G. Randi, G. Rowinski, M. Scarinzi, C. Stivanello, E. Zauli-Sajani, S. Dimakopoulou, K. Elefteriadis, K. Katsouyanni, K. Kelessis, A. Maggos, T. Michalopoulos, N. Pateraki, S. Petrakakis, M. Rodopoulou, S. Sypsa, V. Agis, D. Artiñano, B. Barrera-Gómez, J. Basagaña, X. De La Rosa, J. Diaz, J. Fernandez, R. Jacquemin, B. Karanasiou, A. Linares, C. Sanchez, A.M. Tobias, A. Bidondo, M. Declercq, C. Le Tertre, A. Lozano, P. Medina, S. Pascal, L. Pascal, M.
Abstract: Background: An association between occurrence of wildfires and mortality in the exposed population has been observed in several studies with controversial results for cause-specific mortality. In the Mediterranean area, forest fires usually occur during spring-summer, they overlap with Saharan outbreaks, are associated with increased temperature and their health effects are probably due to an increase in particulate matter. Aim and methods: We analysed the effects of wildfires and particulate matter (PM10) on mortality in 10 southern European cities in Spain, France, Italy and Greece (2003-2010), using satellite data for exposure assessment and Poisson regression models, simulating a case-crossover approach. Results: We found that smoky days were associated with increased cardiovascular mortality (lag 0-5, 6.29%, 95% CIs 1.00 to 11.85). When the effect of PM10 (per 10 mg/m3) was evaluated, there was an increase in natural mortality (0.49%), cardiovascular mortality (0.65%) and respiratory mortality (2.13%) on smoke-free days, but PM10-related mortality was higher on smoky days (natural mortality up to 1.10% and respiratory mortality up to 3.90%) with a suggestion of effect modification for cardiovascular mortality (3.42%, p value for effect modification 0.055), controlling for Saharan dust advections. Conclusions: Smoke is associated with increased cardiovascular mortality in urban residents, and PM10 on smoky days has a larger effect on cardiovascular and respiratory mortality than on other days.
Published: 2015

30. Particulate matter and gaseous pollutants in the Mediterranean Basin: Results from the MED-PARTICLES project

Author: Karanasiou, A. Querol, X. Alastuey, A. Perez, N. Pey, J. Perrino, C. Berti, G. Gandini, M. Poluzzi, V. Ferrari, S. de la Rosa, J. Pascal, M. Samoli, E. Kelessis, A. Sunyer, J. Alessandrini, E. Stafoggia, M. Forastiere, F. Angelini, P. Bisanti, L. Cadum, E. Catrambone, M. Chiusolo, M. Davoli, M. de'Donato, F. Demaria, M. Grosa, M. Faustini, A. Pandolfi, P. Pelosini, R. Pietrodangelo, A. Pizzi, L. Priod, G. Randi, G. Ranzi, A. Rowinski, M. Scarinzi, C. Stivanello, E. Zauli-Sajani, S. Dimakopoulou, K. Elefteriadis, K. Katsouyanni, K. Maggos, T. Michalopoulos, N. Pateraki, S. Petrakakis, M. Rodopoulou, S. Sypsa, V. Artiñano, B. Barrera-Gómez, J. Basagaña, X. Diaz, J. Jacquemin, B. Linares, C. Ostro, B. Tobias, A. Bidondo, M. Declercq, C. Le Tertre, A. Lozano, P. Medina, S. Pascal, M.
Abstract: Previous studies reported significant variability of air pollutants across Europe with the lowest concentrations generally found in Northern Europe and the highest in Southern European countries. Within the MED-PARTICLES project the spatial and temporal variations of long-term PM and gaseous pollutants data were investigated in traffic and urban background sites across Southern Europe. The highest PM levels were observed in Greece and Italy (Athens, Thessaloniki, Turin and Rome) while all traffic sites showed high NO2levels, frequently exceeding the established limit value. High PM2.5/PM10ratios were calculated indicating that fine particles comprise a large fraction of PM10, with the highest values found in the urban background sites. It seems that although in traffic sites the concentrations of both PM2.5and PM10are significantly higher than those registered in urban background sites, the coarse fraction PM2.5-10is more important at the traffic sites. This fact is probably due to the high levels of resuspended road dust in sites highly affected by traffic, a phenomenon particularly relevant for Mediterranean countries. The long-term trends of air pollutants revealed a significant decrease of the concentration levels for PM, SO2and CO while for NO2no clear trend or slightly increasing trends were observed. This reduction could be attributed to the effectiveness of abatement measures and strategies and also to meteorological conditions and to the economic crisis that affected Southern Europe. © 2014 Elsevier B.V.
Published: 2014

31. Which specific causes of death are associated with short term exposure to fine and coarse particles in Southern Europe? Results from the MED-PARTICLES project

Author: Samoli, E. Stafoggia, M. Rodopoulou, S. Ostro, B. Alessandrini, E. Basagan~a, X. Di´az, J. Faustini, A. Gandini, M. Karanasiou, A. Kelessis, A.G. Le Tertre, A. Linares, C. Ranzi, A. Scarinzi, C. Katsouyanni, K. Forastiere, F. Angelini, P. Berti, G. Bisanti, L. Cadum, E. Catrambone, M. Chiusolo, M. Davoli, M. de' Donato, F. Demaria, M. Grosa, M. Ferrari, S. Pandolfi, P. Pelosini, R. Perrino, C. Pietrodangelo, A. Pizzi, L. Poluzzi, V. Priod, G. Randi, G. Rowinski, M. Stivanello, E. Zauli-Sajani, S. Dimakopoulou, K. Elefteriadis, K. Kelessis, A. Maggos, T. Michalopoulos, N. Pateraki, S. Petrakakis, M. Sypsa, V. Agis, D. Artiñano, B. Barrera-Gómez, J. de la Rosa, J. Diaz, J. Fernandez, R. Jacquemin, B. Perez, N. Pey, J. Querol, X. Sanchez, AM. Sunyer, J. Tobias, A. Bidondo, M. Declercq, C. Lozano, P. Medina, S. Pascal, L. Pascal, M. MED-PARTICLES Study group
Abstract: We investigated the short-term effects of particles with aerodynamic diameter less than 2.5μm (PM2.5), between 2.5 and 10μm (PM2.5-10) and less than 10μm (PM10) on deaths from diabetes, cardiac and cerebrovascular causes, lower respiratory tract infections (LRTI) and chronic obstructive pulmonary disease (COPD) in 10 European Mediterranean metropolitan areas participating in the MED-PARTICLES project during 2001-2010.In the first stage of the analysis, data from each city were analyzed separately using Poisson regression models, whereas in the second stage, the city-specific air pollution estimates were combined to obtain overall estimates. We investigated the effects following immediate (lags 0-1), delayed (lags 2-5) and prolonged exposure (lags 0-5) and effect modification patterns by season. We evaluated the sensitivity of our results to co-pollutant exposures or city-specific model choice. We applied threshold models to investigate the pattern of selected associations.For a 10μg/m3 increase in two days' PM2.5 exposure there was a 1.23% (95% confidence interval (95% CI): -1.63%, 4.17%) increase in diabetes deaths, while six days' exposure statistically significantly increased cardiac deaths by 1.33% (95% CI: 0.27, 2.40%), COPD deaths by 2.53% (95% CI: -0.01%, 5.14%) and LRTI deaths by 1.37% (95% CI: -1.94%, 4.78%). PM2.5 results were robust to co-pollutant adjustments and alternative modeling approaches. Stronger effects were observed in the warm season. Coarse particles displayed positive, even if not statistically significant, associations with mortality due to diabetes and cardiac causes that were more variable depending on exposure period, co-pollutant and seasonality adjustment.Our findings provide support for positive associations between PM2.5 and mortality due to diabetes, cardiac causes, COPD, and to a lesser degree to cerebrovascular causes, in the European Mediterranean region, which seem to drive the particles short-term health effects. © 2014 Elsevier Ltd.
Published: 2014

32. Associations between fine and coarse particles and mortality in Mediterranean cities: Results from the MED-PARTICLES project

Author: Samoli, E. Stafoggia, M. Rodopoulou, S. Ostro, B. Declercq, C. Alessandrini, E. Díaz, J. Karanasiou, A. Kelessis, A.G. Tertre, A.L. Pandolfi, P. Randi, G. Scarinzi, C. Zauli-Sajani, S. Katsouyanni, K. Forastiere, F. Alessandrini, E. Angelini, P. Berti, G. Bisanti, L. Cadum, E. Catrambone, M. Chiusolo, M. Davoli, M. de’ Donato, F. Demaria, M. Gandini, M. Grosa, M. Faustini, A. Ferrari, S. Forastiere, F. Pandolfi, P. Pelosini, R. Perrino, C. Pietrodangelo, A. Pizzi, L. Poluzzi, V. Priod, G. Randi, G. Ranzi, A. Rowinski, M. Scarinzi, C. Stivanello, E. Zauli-Sajani, S. Dimakopoulou, K. Elefteriadis, K. Katsouyanni, K. G.Kelessis, A. Maggos, T. Michalopoulos, N. Pateraki, S. Petrakakis, M. Rodopoulou, S. Samoli, E. Sypsa, V. Agis, D. Alguacil, J. Artiñano, B. Barrera-Gómez, J. Basagaña, X. de la Rosa, J. Diaz, J. Fernandez, R. Jacquemin, B. Linares, C. Ostro, B. Pérez, N. Pey, J. Querol, X. Sanchez, AM. Sunyer, J. Tobias, A. Bidondo, M. Declercq, C. Le Tertre, A. Lozano, P. Medina, S. Pascal, L. Pascal, M. MED-PARTICLES Study Group
Subjects: complex mixtures
Abstract: Background: Few studies have investigated the independent health effects of different size fractions of particulate matter (PM) in multiple locations, especially in Europe. Objectives: We estimated the short-term effects of PM with aerodynamic diameter ≤ ; 10; μm (PM10), ≤ 2.5; μm (PM2.5), and between 2.5 and 10; μm (PM2.5-10) on all-cause, cardiovascular, and respiratory mortality in 10 European Mediterranean metropolitan areas within the MED-PARTICLES project. Methods: We analyzed data from each city using Poisson regression models, and combined city-specific estimates to derive overall effect estimates. We evaluated the sensitivity of our estimates to co-pollutant exposures and city-specific model choice, and investigated effect modification by age, sex, and season. We applied distributed lag and threshold models to investigate temporal patterns of associations. Results: A 10-μg/m3 increase in PM2.5 was associated with a 0.55% (95% CI: 0.27, 0.84%) increase in all-cause mortality (0-1 day cumulative lag), and a 1.91% increase (95% CI: 0.71, 3.12%) in respiratory mortality (0-5 day lag). In general, associations were stronger for cardiovascular and respiratory mortality than all-cause mortality, during warm versus cold months, and among those ≥ 75 versus < 75 years of age. Associations with PM2.5-10 were positive but not statistically significant in most analyses, whereas associations with PM10 seemed to be driven by PM2.5. Conclusions: We found evidence of adverse effects of PM2.5 on mortality outcomes in the European Mediterranean region. Associations with PM2.5-10 were positive but smaller in magnitude. Associations were stronger for respiratory mortality when cumulative exposures were lagged over 0-5 days, and were modified by season and age.
Published: 2013

33. Short-term associations between fine and coarse particulate matter and hospitalizations in Southern Europe: Results from the MED-PARTICLES project

Author: Stafoggia, M. Samoli, E. Alessandrini, E. Cadum, E. Ostro, B. Berti, G. Faustini, A. Jacquemin, B. Linares, C. Pascal, M. Randi, G. Ranzi, A. Stivanello, E. Forastiere, F. Angelini, P. Bisanti, L. Catrambone, M. Chiusolo, M. Davoli, M. de’ Donato, F. Demaria, M. Gandini, M. Grosa, M. Ferrari, S. Pandolfi, P. Pelosini, R. Perrino, C. Pietrodangelo, A. Pizzi, L. Poluzzi, V. Priod, G. Rowinski, M. Scarinzi, C. Zauli-Sajani, S. Dimakopoulou, K. Elefteriadis, K. Katsouyanni, K. Kelessis, A. Maggos, T. Michalopoulos, N. Pateraki, S. Petrakakis, M. Rodopoulou, S. Sypsa, V. Artiñano, B. Barrera-Gómez, J. Basagaña, X. de la Rosa, J. Diaz, J. Karanasiou, A. Pey, J. Querol, X. Sunyer, J. Tobias, A. Bidondo, M. Declercq, C. Le Tertre, A. Lozano, P. Medina, S. Pascal, L. MED-PARTICLES Study Group
Subjects: complex mixtures
Abstract: Background: Evidence on the short-term effects of fine and coarse particles on morbidity in Europe is scarce and inconsistent. Objectives: We aimed to estimate the association between daily concentrations of fine and coarse particles with hospitalizations for cardiovascular and respiratory conditions in eight Southern European cities, within the MED-PARTICLES project. Methods: City-specific Poisson models were fitted to estimate associations of daily concentrations of particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5), ≤ 10 (PM10), and their difference (PM2.5-10) with daily counts of emergency hospitalizations for cardiovascular and respiratory diseases. We derived pooled estimates from random-effects meta-analysis and evaluated the robustness of results to co-pollutant exposure adjustment and model specification. Pooled concentration-response curves were estimated using a meta-smoothing approach. Results: We found significant associations between all PM fractions and cardiovascular admissions. Increases of 10 μg/m3 in PM2.5, 6.3 μg/m3 in PM2.5-10, and 14.4 μg/m3 in PM10 (lag 0-1 days) were associated with increases in cardiovascular admissions of 0.51% (95% CI: 0.12, 0.90%), 0.46% (95% CI: 0.10, 0.82%), and 0.53% (95% CI: 0.06, 1.00%), respectively. Stronger associations were estimated for respiratory hospitalizations, ranging from 1.15% (95% CI: 0.21, 2.11%) for PM10 to 1.36% (95% CI: 0.23, 2.49) for PM2.5 (lag 0-5 days). Conclusions: PM2.5 and PM2.5-10 were positively associated with cardiovascular and respiratory admissions in eight Mediterranean cities. Information on the short-term effects of different PM fractions on morbidity in Southern Europe will be useful to inform European policies on air quality standards.
Published: 2013

34. Heroin maintenance for chronic heroin dependents

Author: M, Ferri, M, Davoli, and C A, Perucci
Subjects: Heroin, Narcotics, Heroin Dependence, Humans, Randomized Controlled Trials as Topic
Abstract: Dependent heroin users are characterised by the persistence of use in spite of the difficulties they experience with health, law, social achievements and personal relationships. The present review will consider maintenance treatment in which the patients enter programs of pharmacological administration tailored to achieve patient stabilisation. Many medications have been used for this purpose such as: Methadone, Buprenorphine and LAAM. The present review will focus on maintenance treatment through the prescription of heroin.To assess the efficacy and acceptability of heroin maintenance versus methadone or other substitution treatments for opioid dependence, in retaining patients in treatment; reducing the use of illicit substances and improving health and social functioning.The Cochrane Central Register of Trials (CENTRAL) issue 4, 2002; MEDLINE (on Silver Platter) 1966-2002; EMBASE (on OVID) 1980-2000 and CINAHL till 2000 were searched. There was no language or publication year restrictions. Many researchers were contacted for information.Randomised controlled trials of heroin (alone or combined with methadone) maintenance treatment compared with any other pharmacological treatments.The trials were independently assessed for inclusion and methodological quality by the reviewers. Data were extracted independently and double checked. Studies were not pooled together because of heterogeneity.2400 references were obtained and 20 studies were eligible, 4 met the inclusion criteria for a total of 577 patients. The studies included could not be analysed cumulatively because of heterogeneity of interventions and outcomes considered. Two studies compared injected heroin to oral methadone for 1 year (270 patients) but considered different outcomes; one study compared injected heroin and methadone to oral methadone for 6 months (51 patients); and one compared inhaled heroin and methadone to oral methadone for 1 year (235 patients). Retention in treatment: in two studies there was no statistical difference between groups; one study (N=90) had a RR=2.49 (95% CI 1.51-4.10) in favour of heroin; one study (N=235) had a RR 0.79 (95%CI 0.68-0.90) in favour of methadone. Relapse to illegal heroin use, based on self report: in one study the proportion of people still using heroin were 64% in the heroin group, 59% methadone group; in the other study the RR was 0.33 (95%CI 0.15-0.72) in favour of heroin. The remaining studies did not provide the data. Criminal offence: one of the two studies which provided details about this showed the potential of heroin prescription in reducing the risk of being charged RR 0.32 (95% CI 0.14-0.78). Social functioning: the two studies reporting this outcome did not show statistical difference between intervention groups. The two most recent studies considered criminal offence and social functioning as part of a multidomain outcome measure and showed higher improvement among those treated with heroin plus methadone over those on methadone only.No definitive conclusions about the overall effectiveness of heroin prescription is possible because of non-comparability of the experimental studies available to be included in this review. Results favouring heroin treatment come from studies conducted in countries where the treatment system is comprehensive and easy accessible Methadone Maintenance Treatment at effective dosages is available. In those studies heroin prescription was addressed to patients who had failed previous methadone treatments.
Published: 2003

35. Methadone at tapered doses for the management of opioid withdrawal

Author: L, Amato, M, Davoli, M, Ferri, and R, Ali
Subjects: Narcotics, Humans, Opioid-Related Disorders, Methadone, Randomized Controlled Trials as Topic, Substance Withdrawal Syndrome
Abstract: Despite widespread use in many countries of tapered methadone for detoxification from opiate dependence, the evidence of efficacy to prevent relapse and promote lifestyle change has not been systematically evaluated.To determine whether tapered methadone is effective to manage withdrawal from opioids.We searched: the Cochrane Controlled Trials Register (Issue 1, 2000), MEDLINE (OVID 1966-2000), EMBASE (1980-2000); scan of reference list of relevant articles; personal communication; conference abstracts; unpublished trials from pharmaceutical industry; Internet (NIDA, Clinical Trials.org, BMJ).All randomised controlled trials which focus on the use of tapered methadone (length of treatment max 30 days) versus all other pharmacological detoxification treatments, placebo and different modalities of methadone detoxification programs for the treatment of opiate withdrawal. Trials including patients with additional diagnoses such as benzodiazepine dependence were also eligible.One reviewer (LA) assessed studies for inclusion and undertook data extraction. Inclusion decisions and the overall process were confirmed by consultation between reviewers. Qualitative assessments of the methodology of eligible studies were carried out using validated checklists. Where possible analysis was carried out according to the "intention to treat" principles.20 studies were included in the review, with 1357 people randomised. 10 studies compared methadone with adrenergic agonists, 7 studies compared different modalities of methadone detoxification, 2 studies compared methadone with other opioid agonists, 1 study compared methadone with chlordiazepoxide one with placebo. The conclusions of the 10 studies that compared methadone with adrenergic agonists showed no substantial clinical difference of the two treatments in terms of retention in treatment, degree of discomfort and detoxification success rates. The conclusions of the 6 studies that compare different methadone reduction schedules, showed that different types of methadone withdrawal schedule produce different responses in terms of time course of withdrawal, the severity of withdrawal response and possibly in terms of subsequent engagement with treatment. Regarding the studies that compare methadone with other opioid agonists, in Sorensen 1982 methadyl acetate performed similarly to methadone on most process and outcome measures, while in Tennant 1975, methadone reduced severity of withdrawal and had fewer drop-outs than did a propoxyphene group. In Drummond 1989, using chlordiazepoxide vs methadone, the results suggest that the two drugs had similar results in terms of overall effectiveness.San 1992 compared methadone with placebo and found more severe withdrawal and more drop outs in the placebo group. The results indicate that tapered methadone and other medications used in the included studies are effective in the treatment of the heroin withdrawal syndrome, although symptoms experienced by subjects differed according to the medication used and the program adopted. It seems that regardless of which medication is selected for heroin detoxification, the rates of subsequent heroin abstinence are about equal. This suggests that the medications are similar in terms of overall effectiveness. Improvements were achieved when other services such as counseling and other supporting services were offered contemporaneously with detoxification.Data from literature are hardly comparable; programs vary widely with regard to duration, design and treatment objectives, impairing the application of meta-analysis. Results of many outcomes could not be summarised because they were presented either in graphical form or provided only statistical tests and p-values. For most studies standard deviation for continuous variables were not provided. The studies included in this review confirm that slow tapering with temporary substitution of long acting opioids, accompanied by medicaopioids, accompanied by medical supervision and ancillary medications can reduce withdrawal severity. Nevertheless the majority of patients relapsed to heroin use. However this cannot be considered a goal for a detoxification as heroin dependence is a chronic, relapsing disorder and the goal of detoxification should be to remove or reduce dependence on heroin in a controlled and human fashion and not a treatment for heroin dependence.
Published: 2002

36. P2-141 Definition and validation of an algorithm to identify COPD patients from administrative databases

Author: Silvia Cascini, M Davoli, Danilo Fusco, Valeria Belleudi, Massimo Arcà, L Bauleo, Nera Agabiti, Ursula Kirchmayer, and Luigi Pinnarelli
Subjects: COPD, Database, Epidemiology, Copd patients, business.industry, Public Health, Environmental and Occupational Health, External validation, Pulmonary disease, computer.software_genre, medicine.disease, respiratory tract diseases, Respiratory failure, medicine, Outpatient clinic, Medical prescription, business, computer, Algorithm, Record linkage
Abstract: Introduction Administrative databases are increasingly used to identify patients with chronic conditions, however the optimal methodology for Chronic Obstructive Pulmonary Disease (COPD) is still debated. Objective To develop and validate an algorithm to identify patients with COPD in Lazio (2 625 102 residents over 45) linking clinical and administrative data. Methods From the regional hospitalisation, drug prescription and outpatient registries, through record linkage, we identified patterns of specific drug use (minimum 2 prescription during 12 months) and COPD hospitalisations during a 9-year period in 428 patients with COPD, who attended an outpatient clinic in 2006, and in 2140 people without COPD. Through a Bootstrap-Stepwise procedure we selected COPD associated factors. We validated the algorithm through internal (cross-validation-bootstrap, jack-knife) and external validation (comparison with external COPD patients with confirmed diagnosis). Results A total of 205 611 (7.8%) COPD patients were identified. Factors associated with COPD were: prescription of β2-agonists, anticholinergics, corticosteroids, oxygen, and previous hospitalisation for COPD and respiratory failure. For each patient we estimated an expected probability to suffer from COPD. Depending on the cut-point of expected probability, sensibility (SE) ranged from 0.15 to 0.87 and specificity (SP) from 0.79 to 0.99. We defined a cut-point of 0.30 (SE=64%; SP=97%) to identify the COPD patients. Applying our algorithm on external COPD patients we succeeded to identify 86%. Conclusion The algorithm showed good performance to identify COPD patients among those individuals registered in the regional healthcare system confirming the strength of administrative data for monitoring chronic diseases.
Published: 2011
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37. P1-193 Two-years mortality after evidence based drug therapy of acute myocardial infarction: a population-based cohort study in Rome, Italy

Author: L Bauleo, Ursula Kirchmayer, Nera Agabiti, M D Martino, Luigi Pinnarelli, Massimo Arcà, Danilo Fusco, M Davoli, and Valeria Belleudi
Subjects: Drug, education.field_of_study, Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, media_common.quotation_subject, Population, Public Health, Environmental and Occupational Health, medicine.disease, Logistic regression, Pharmacotherapy, medicine, Observational study, Myocardial infarction, Medical prescription, education, business, media_common, Cohort study
Abstract: Introduction Clinical guidelines recommend treatment with evidence-based (EB) drug therapy (antiplatelets, β-blockers, agents acting on the renin-angiotensin system, statins) for patients with acute myocardial infarction (AMI). Results on long term outcomes from observational population studies are scarce. Objectives Analysing the association between EB drug therapy and 2 years mortality in AMI patients. Methods Twothousand-twohundred-and-four AMI patients, discharged in 2006 and resident in Rome were selected from the Hospital Information System, excluding deaths during the first month after discharge. Exposure information was collected from the drug claims data considering EB drug prescriptions at discharge and during the first month; exposure was defined as at least one prescription, comparing different composite treatments (1, 2, 3 or 4 EB drug groups). The association between exposure to EB drug therapy and all-cause mortality during a 24 months follow-up was analysed through logistic regression, adjusting for gender, age and co-morbidities. Results Most patients were treated with EB drug combinations (0: 9.5%, 1: 4.6%, 2: 14.7%, 3: 30.1%, 4: 41.1%); 7.4% of the patients died during follow-up. Mortality risk decreased with increasing number of prescribed EB drugs; combinations of 3 or 4 EB drugs were associated with a significant protective effect vs no EB drugs (4 vs 0 EB drugs: OR adj =0.46; 95% CI 0.27 to 0.78; 3 vs 0 EB drugs: OR adj =0.50; 95% CI 0.29 to 0.86; 2 vs 0 EB drugs: OR adj =0.69; 95% CI 0.39 to 1.23; 1 vs 0 EB drugs: OR adj =0.49; 95% CI 0.21 to 1.13). Conclusions In Rome, most patients are treated with EB drugs after AMI; first-month poly-drug therapy is associated with reduction in 2 years mortality.
Published: 2011
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38. Naltrexone maintenance treatment for opioid dependence

Author: U, Kirchmayer, M, Davoli, and A, Verster
Subjects: Male, Narcotic Antagonists, Humans, Female, Controlled Clinical Trials as Topic, Opioid-Related Disorders, Naltrexone
Abstract: Despite widespread use of naltrexone maintenance in many countries for more than a decade, the evidence of its effects has not yet been systematically evaluated.To evaluate the effects of naltrexone maintenance treatment in preventing relapse in opioid addicts after detoxification.We searched MEDLINE (1973-first year of naltrexone use in humans-July 2000), EMBASE (1974-July 2000), Cochrane Controlled Trials Register (Cochrane Library issue 2001.4) and handsearched the "Bolletino per le Farmacodipendenze e l'Alcolismo" (1978 to 1997) and reference lists of relevant articles. We contacted pharmaceutical producers of naltrexone, authors and other Cochrane review groups. Date of most recent searches: December 2001.All controlled studies of naltrexone; treatment of heroin addicts after detoxification.Reviewers evaluated data independently and analysed outcome measures taking into consideration adherence to and success of the study intervention. Data were extracted and analysed stratifying for the three categories of study quality. Where possible, meta-analysis was performed.Eleven studies met the criteria for inclusion in this review, even if not all of them were randomised. The methodological quality of the included studies varied, but was generally poor. Meta-analysis could be performed to a very low degree only, because the studies and their outcome measures were very heterogeneous. A statistically significant reduction of (re-)incarcerations was found for patients treated with naltrexone and behaviour therapy in respect to those treated with behaviour therapy only. The other outcomes considered in the meta-analysis did not yield any significant results. Final conclusions on whether naltrexone treatment may be considered effective in maintenance therapy cannot be drawn from the clinical trials available so far.The available trials do not allow a final evaluation of naltrexone maintenance treatment yet. A trend in favour of treatment with naltrexone was observed for certain target groups (particularly people who are highly motivated), as has been previously described in the literature.
Published: 2000

39. Mortality among patients with ulcerative colitis: Rome 1970-1989

Author: M, Davoli, C, Prantera, E, Berto, M L, Scribano, and D, D'Ippoliti
Subjects: Adult, Male, Time Factors, Rome, Case-Control Studies, Cause of Death, Confidence Intervals, Odds Ratio, Humans, Colitis, Ulcerative, Female, Prospective Studies, Sex Distribution, Follow-Up Studies
Abstract: The aim of this study was to analyze the pattern of mortality among patients with ulcerative colitis (UC) and compare it with mortality in the general population of the same age and sex. All patients with UC admitted to one of the Inflammatory Bowel Disease Clinics in Rome, from January 1970 to December 31, 1989 were enrolled. Vital status was ascertained through the Registry Office of the last municipality of residence as of July 1, 1990. Cause of death was ascertained through record linkage with the national or regional mortality file and coded using the ninth revision of the International Classification of Diseases. Standardized Mortality Ratios (SMRs) were computed to compare mortality among UC patients with mortality in the general population of the same age and sex. Out of a total of 508 UC patients admitted during the study period, 27 deaths were observed, compared with 27.6 expected (SMR = 98). After excluding prevalent cases, an excess risk of death was observed among newly diagnosed cases in the first year after diagnosis (SMR = 644; p0.001); ulcerative colitis was the main reason for this excess mortality. Mortality for other diseases was close to that expected. In conclusion, ulcerative colitis impairs life expectancy in the first year after diagnosis, while no excess mortality seems to be present afterwards.
Published: 1997

40. OP94 Evidence for the Effectiveness Ofopiate Substitution Treatment in Relation to HIV Transmission in People who Inject Drugs: A Systematic Review and Meta-Analysis

Author: Natasha K. Martin, Peter Vickerman, Matthew Hickman, Georgina J MacArthur, M Davoli, Julie Bruneau, and S Minozzi
Subjects: Harm reduction, Epidemiology, Transmission (medicine), business.industry, Public Health, Environmental and Occupational Health, Psychological intervention, Heroin, Meta-analysis, Environmental health, medicine, Risk factor, business, medicine.drug, Cohort study, Methadone
Abstract: Background Injecting drug use is a major risk factor for the acquisition and transmission of HIV among people who inject drugs (PWID), and between PWID and the wider community. Worldwide there are an estimated 15.9 million PWID of whom 3 million may be HIV-positive. Methadone and buprenorphine (opiate substitution treatments, OST) reduce heroin use, injecting risk behaviour, and drug related mortality and are included in the World Health Organization list of essential medicines. A small number of individual cohort studies and a Cochrane narrative systematic review suggest that OST may reduce HIV incidence, but no pooled quantitative synthesis has been carried out. We have undertaken a systematic review and meta-analysis of published and unpublished studies to quantify the effect of OST on HIV transmission. Methods Medline, EMBASE and PsychINFO were searched to October 2011 to identify studies that examined the effectiveness of OST in relation to HIV transmission. Authors of prospective studies that assessed HIV incidence in PWID were contacted to obtain unpublished data. Results Fifteen studies conducted in seven countries were relevant for inclusion. Data from ten of the studies were pooled, two of which were unpublished. Analysis included over 22,000 person-years of follow-up and 738 incident HIV infections. Preliminary random effects meta-analysis demonstrates that OST reduces risk of HIV transmission among PWID by 49% (RR 0.51, 95% CI 0.37–0.71; p 2 59.5%, χ 2 22.2, p=0.008). Study-level covariates including publication year, gender, median age, and ethnicity of participants did not significantly influence the impact of OST in meta-regression analyses. However, sub-group analysis demonstrated that whilst continuous OST significantly reduced risk of HIV infection, the effectiveness of interrupted or detoxification treatment was less clear (RR 1.26, 95% CI 0.77–2.07; p=0.360). Conclusion These preliminary data provide further evidence that OST can reduce the risk of HIV infection among PWID and for the first time quantify the effect. Ensuring sufficient coverage of OST as part of a package of harm reduction interventions is critical to reduce the burden of HIV among PWID and to prevent onward transmission between PWID and to the wider community.
Published: 2012
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41. P2-142 Effect of chronic therapy with statins before infarction in patients with acute myocardial infarction

Author: Chiara Sorge, Danilo Fusco, Valeria Belleudi, Carlo A. Perucci, M Davoli, Ursula Kirchmayer, Nera Agabiti, and Anna Patrizia Barone
Subjects: medicine.medical_specialty, Statin, Epidemiology, business.industry, medicine.drug_class, Confounding, Public Health, Environmental and Occupational Health, Infarction, Disease, Logistic regression, medicine.disease, Surgery, Lazio region, Internal medicine, Medicine, In patient, cardiovascular diseases, Myocardial infarction, business
Abstract: Introduction Efficacy of preventive therapy with statins in reducing mortality and cardiovascular morbidity in patients with and without cardiovascular disease has been shown in clinical settings, but effectiveness results were not reported. Objectives To evaluate whether chronic statin therapy before infarction reduces mortality within 30 days after acute myocardial infarction (AMI) and investigate potential confounders/effect modifiers (gender, age and comorbidities). Methods Hospital discharges of AMI patients (≥35 years) resident in the Lazio region in 2007–2008, were selected, excluding patients with AMI or revascularisation procedures (aortocoronary bypass, PTCA) in the preceding 9 years. Statin use (ATC: C10AA, C10B) during 1 year preceding the index admission was assessed through the drug claims information system; patients were defined “partially adherent” with 20%–80% days covered by statin doses and “adherent” with 80% and more coverage. Crude and adjusted 30-day mortality risks of statin users vs nonusers were estimated using logistic regression models. The role of gender and age as effect modifiers, interaction terms were included in the model. Results Among 6790 AMI patients statin users showed reduced mortality risk compared to nonusers (OR=0.75, 95% CI 0.58 to 0.98 for partially adherent, OR=0.85 95% CI 0.66 to 1.09 for adherent). The protective effect was more evident in females (OR=0.74, 95% CI 0.52 to 1.05 for partially adherent, OR=0.67 95% CI 0.46 to 0.97 for adherent) and in older people (>85 years) (OR=0.84, 95% CI 0.50 to 1.40 for partially adherent, OR=0.51 95% CI 0.29 to 0.91 for adherent). Conclusions Chronic statin therapy before infarction reduced 30 days mortality in patients with AMI, especially in females and elderly.
Published: 2011
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42. Longitudinal and cross sectional mortality studies in injecting drug-users

Author: Francesco Forastiere, E Rapiti, M. Davoli, Carlo A. Perucci, and D. D. Abeni
Subjects: Adult, Male, Gerontology, Drug, Adolescent, Epidemiology, business.industry, Cross-sectional study, media_common.quotation_subject, Public Health, Environmental and Occupational Health, Middle Aged, Suicide, Scotland, Cause of Death, HIV Seropositivity, Humans, Medicine, Female, Drug Overdose, Substance Abuse, Intravenous, business, Research Article, Retrospective Studies, media_common
Abstract: The aim was to quantify all cause mortality among injecting drug users.This was a retrospective analysis of 1989 data on injecting drug users and mortality obtained from three independent agencies: the Procurator Fiscal's Office, the General Register Office, and the Scottish HIV-test register.Greater Glasgow, Scotland.Drug injectors, estimated population 9424.81 names were found using the three sources to identify deaths. After removing duplicates, 51 deaths were found. This represented a mortality rate of 0.54% in the estimated population. Among female injectors the mortality rate was 0.85%, significantly higher than the rate of 0.42% among male injectors (95% CI for the true difference in mortality rates between female and male injectors was 0.31%-0.55%). Over 90% of deaths were attributed to overdose or suicide. Although AIDS caused only one death, 19% of cases (5/27) whose HIV antibody status could be ascertained were positive. The mortality rate among HIV positive injectors (3.8%) was significantly higher than among HIV negative injectors (0.49%).Comprehensive coverage using three data sources revealed a far greater annual number of all cause deaths among injectors than would have been expected from previous research. The observed mortality rate was lower than in previous studies where the denominators used to calculate rates had an element of underenumeration. For the foreseeable future it is unlikely that AIDS will have much impact on mortality among injectors in Glasgow, because of the low prevalence of HIV infection among injectors in the city, and because HIV positive injectors are dying for reasons other than AIDS; rather, overdose and suicide will continue to be the main causes of death.
Published: 1994
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43. Pleural mesothelioma risk in the construction industry: a case–control study in Italy, 2000–2018

Author: Stefania Curti, Stefano Mattioli, Dario Consonni, Sara Piro, Lucia Miligi, L Mangone, Maria Teresa Landi, Neil E Caporaso, Carolina Mensi, L Giovannetti, Elisabetta Chellini, Elisa Romeo, Alessandro Marinaccio, Antonella Stura, A Martini, Giovanni Brandi, Carlo Genova, M Gangemi, M Davoli, L Richiardi, P Michelozzi, G Serio, Luigi Vimercati, A Caputi, Enrica Migliore, AC Pesatori, L De Maria, Veronica Casotto, B Dallari, M Bonzini, U Fedeli, Alessandra Binazzi, Corrado Negro, Antonio Romanelli, Francesco Carrozza, Domenica Cavone, Federico Tallarigo, Massimo Melis, C Brentisci, M Gilardetti, C Storchi, O Sala, V Cacciarini, L Ancona, Sg Lio, G Frasca, Mc Giurdanella, C Martorana, P Rollo, E Spata, G Dardanoni, S Scondotto, S Stecchi, D Mirabelli, P De Michieli, Simona Stella, Carmela Gioscia, Silvia Eccher, Stefano Murano, Vera Comiati, Flavia D'Agostin, Lucia Benfatto, Iolanda Grappasonni, Gabriella Madeo, Ilaria Cozzi, Staniscia Tommaso, Michele Labianca, Giuseppe Cascone, D Di Marzio, S Rugarli, C Pascucci, A Balestri, MC Delfino, F Pentimone, and MR Angius
Subjects: Medicine
Abstract: Objectives Workers in the construction industry have been exposed to asbestos in various occupations. In Italy, a National Mesothelioma Registry has been implemented more than 20 years ago. Using cases selected from this registry and exploiting existing control data sets, we estimated relative risks for pleural mesothelioma (PM) among construction workers.Design Case–control study.Setting Cases from the National Mesothelioma Registry (2000–2018), controls from three previous case–control studies.Methods We selected male PM incident cases diagnosed in 2000–2018. Population controls were taken from three studies performed in six Italian regions within two periods (2002–2004 and 2012–2016). Age-adjusted and period-adjusted unconditional logistic regression models were fitted to estimate odds ratios (OR) for occupations in the construction industry. We followed two approaches, one (primary) excluding and the other (secondary) including subjects employed in other non-construction blue collar occupations for >5 years. For both approaches, we performed an overall analysis including all cases and, given the incomplete temporal and geographic overlap of cases and controls, three time or/and space restricted sensitivity analyses.Results The whole data set included 15 592 cases and 2210 controls. With the primary approach (4797 cases and 1085 controls), OR was 3.64 (2181 cases) for subjects ever employed in construction. We found elevated risks for blue-collar occupations (1993 cases, OR 4.52), including bricklayers (988 cases, OR 7.05), general construction workers (320 cases, OR 4.66), plumbers and pipe fitters (305 cases, OR 9.13), painters (104 cases, OR 2.17) and several others. Sensitivity analyses yielded very similar findings. Using the secondary approach, we observed similar patterns, but ORs were remarkably lower.Conclusions We found markedly increased PM risks for most occupations in the construction industry. These findings are relevant for compensation of subjects affected with mesothelioma in the construction industry.
Published: 2023
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44. Prevalence and features of delirium in older patients admitted to rehabilitation facilities

Author: Sidoli, Chiara, Zambon, Antonella, Tassistro, Elena, Rossi, Emanuela, Mossello, Enrico, Inzitari, Marco, Cherubini, Antonio, Marengoni, Alessandra, Morandi, Alessandro, Bellelli, Giuseppe, Tarasconi, A, Sella, M, Paternò, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D’Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell’Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Geriatria, A, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambar, V, Saitta, A, Corica, F, Braga, M, Servi, Null, Ettorre, E, Camellini Bellelli, C G, Annoni, G, Marengoni, A, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuar, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl’Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samysalamafahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Di, F, Pezzoni, D, Platto, C, D’Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi Muti, L E, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Riccò, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D’Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Mossello, E, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccalà, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, Saggioro, D, Sidoli, Chiara, Zambon, Antonella, Tassistro, Elena, Rossi, Emanuela, Mossello, Enrico, Inzitari, Marco, Cherubini, Antonio, Marengoni, Alessandra, Morandi, Alessandro, Bellelli, Giuseppe, A Tarasconi, M Sella, G Paternò, G Faggian, C Lucarelli, N De Grazia, C Alberto, L Porcella, I Nardiello, E Chimenti, M Zeni, E Romairone, C Minaglia, C Ceccotti, G Guerra, G Mantovani, F Monacelli, C Minaglia, T Candiani, F Santolini, C Minaglia, M Rosso, V Bono, S Sibilla, P Dal Santo, M Ceci, P Barone, T Schirinzi, A Formenti, G Nastasi, G Isaia, D Gonella, A Battuello, S Casson, D Calvani, F Boni, A Ciaccio, R Rosa, G Sanna, S Manfredini, L Cortese, M Rizzo, R Prestano, A Greco, M Lauriola, G Gelosa, V Piras, M Arena, D Cosenza, A Bellomo, M LaMontagna, L Gabbani, L Lambertucci, S Perego, G Parati, G Basile, V Gallina, G Pilone, C Giudice, L Pietrogrande, M Mosca, I Corazzin, P Rossi, V Nunziata, F D’Amico, A Grippa, S Giardini, R Barucci, A Cossu, L Fiorin, M Arena , M Distefano, M Lunardelli, M Brunori, I Ruffini, E Abraham, A Varutti, E Fabbro, A Catalano, G Martino, D Leotta, A Marchet, G Dell’Aquila, A Scrimieri, M Davoli, M Casella, A Cartei, G Polidori, G Basile, D Brischetto, S Motta, R Saponara, P Perrone, G Russo, D Del, C Car, T Pirina, S Franzoni, A Cotroneo, F Ghiggia, G Volpi, C Menichetti, M Bo, A Panico, P Calogero, G Corvalli, M Mauri, E Lupia, R Manfredini, F Fabbian, A March, M Pedrotti, M Veronesi, E Strocchi, C Borghi, A Bianchetti, A Crucitti, V DiFrancesco, G Fontana, A Geriatria, L Bonanni, F Barbone, C Serrati, G Ballardini, M Simoncelli, G Ceschia, C Scarpa, R Brugiolo, S Fusco, T Ciarambino, C Biagini, E Tonon, M Porta , D Venuti, M DelSette, M Poeta, G Barbagallo, G Trovato, A Delitala, P Arosio, F Reggiani, G Zuliani, B Ortolani, E Mussio, A Girardi, A Coin, G Ruotolo, A Castagna, M Masina, R Cimino, A Pinciaroli, G Tripodi, F Cassadonte, M Vatrano, L Scaglione, P Fogliacco, C Muzzuilini, F Romano, A Padovani, L Rozzini, A Cagnin, F Fragiacomo, G Desideri, E Liberatore, A Bruni, G Orsitto, M Franco, L Bonfrate, M Bonetto, N Pizio, G Magnani, G Cecchetti, A Longo, V Bubba, L Marinan, M Cotelli, M Turla, M Brunori, M Sessa, L Abruzzi, G Castoldi, D LoVetere, C Musacchio, M Novello, A Cavarape, A Bini, A Leonardi, F Seneci, W Grimaldi, F Seneci, F Fimognari, V Bambar, A Saitta, F Corica, M Braga, Servi, E Ettorre , C G Camellini Bellelli, G Annoni, A Marengoni, A Bruni, A Crescenzo, G Noro, R Turco, M Ponzetto, L Giuseppe, B Mazzei, G Maiuri, D Costaggiu, R Damato, E Fabbro, M Formilan, G Patrizia, L Santuar , M Gallucci, C Minaglia, M Paragona, P Bini, D Modica, C Abati, M Clerici, I Barbera, F NigroImperiale, A Manni, C Votino, C Castiglioni, M Di, M Degl’Innocenti, G Moscatelli, S Guerini, C Casini, D Dini, S DeNotariis, F Bonometti, C Paolillo, A Riccardi, A Tiozzo, A SamySalamaFahmy, A Riccardi, C Paolillo, M DiBari, S Vanni, A Scarpa, D Zara, P Ranieri, M Alessandro, P Calogero, G Corvalli, F Di, D Pezzoni, C Platto, V D’Ambrosio, C Ivaldi, P Milia, F DeSalvo, C Solaro, M Strazzacappa, M Bo, A Panico, M Cazzadori, M Bonetto, M Grasso, E Troisi, G Magnani, G Cecchetti, V Guerini, B Bernardini, C Corsini, S Boffelli, A Filippi, K Delpin, B Faraci, E Bertoletti, M Vannucci, P Crippa, A Malighetti, C Caltagirone, S DiSant, D Bettini, F Maltese, M Formilan, G Abruzzese, C Minaglia, D Cosimo, M Azzini, M Cazzadori, M Colombo, G Procino, S Fascendini, F Barocco, P Del, F D’Amico, A Grippa , A Mazzone, M Cottino, G Vezzadini, S Avanzi, C Brambilla, S Orini, F Sgrilli, A Mello, L E Lombardi Muti, B Dijk , S Fenu, C Pes, P Gareri, A Castagna, M Passamonte, R Rigo, L Locusta, L Caser, G Rosso, S Cesarini, R Cozzi, C Santini, P Carbone, I Cazzaniga, R Lovati, A Cantoni, P Ranzani, D Barra, G Pompilio, S Dimori, S Cernesi, C Riccò, F Piazzolla, E Capittini, C Rota, F Gottardi, L Merla, A Barelli, A Millul , G De, G Morrone, M Bigolari, C Minaglia, M 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Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D'Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccala, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, and Saggioro, D
Subjects: Aging, Disability, Rehabilitation, Delirium, Dementia, Physical restraint, Cross-Sectional Studies, Activities of Daily Living, mental disorders, Prevalence, Humans, Geriatrics and Gerontology, Aged
Abstract: Background: Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation. Aim: We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three editions of the “Delirium Day project”. Methods: We conducted a cross-sectional study in which 1237 older patients (age ≥ 65 years old) admitted to 50 Italian rehabilitation wards during the three editions of the “Delirium Day project” (2015 to 2017) were included. Delirium was evaluated through the 4AT and its motor subtype with the Delirium Motor Subtype Scale. Results: Delirium was detected in 226 patients (18%), and the most recurrent motor subtype was mixed (37%), followed by hypoactive (26%), hyperactive (21%) and non-motor one (16%). In a multivariate Poisson regression model with robust variance, factors associated with delirium were: disability in basic (PR 1.48, 95%CI: 1.17–1.9, p value 0.001) and instrumental activities of daily living (PR 1.58, 95%CI: 1.08–2.32, p value 0.018), dementia (PR 2.10, 95%CI: 1.62–2.73, p value < 0.0001), typical antipsychotics (PR 1.47, 95%CI: 1.10–1.95, p value 0.008), antidepressants other than selective serotonin reuptake inhibitors (PR 1.3, 95%CI: 1.02–1.66, p value 0.035), and physical restraints (PR 2.37, 95%CI: 1.68–3.36, p value < 0.0001). Conclusion: This multicenter study reports that 2 out 10 patients admitted to rehabilitations had delirium on the index day. Mixed delirium was the most prevalent subtype. Delirium was associated with unmodifiable (dementia, disability) and modifiable (physical restraints, medications) factors. Identification of these factors should prompt specific interventions aimed to prevent or mitigate delirium.
Published: 2022
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45. The association between low skeletal muscle mass and delirium: results from the nationwide multi-centre Italian Delirium Day 2017

Author: Zucchelli, A, Manzoni, F, Morandi, A, Di Santo, S, Rossi, E, Valsecchi, Mg, Inzitari, M, Cherubini, A, Bo, M, Mossello, E, Marengoni, A, Bellelli, G, Tarasconi, A, Sella, M, Auriemma, S, Paternò, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Margola, A, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Giani, A, Famularo, S, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Ballestrero, A, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, De, F, Pietrogrande, L, De, B, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D'Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell'Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Bianchetti, A, Crucitti, A, Di Francesco, V, Fontana, G, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, 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Basile, V Gallina, G Pilone, C Giudice, F De, L Pietrogrande, B De, M Mosca, I Corazzin, P Rossi, V Nunziata, F D'Amico, A Grippa, S Giardini, R Barucci, A Cossu, L Fiorin, M Arena, M Distefano, M Lunardelli, M Brunori, I Ruffini, E Abraham, A Varutti, E Fabbro, A Catalano, G Martino, D Leotta, A Marchet, G Dell'Aquila, A Scrimieri, M Davoli, M Casella, A Cartei, G Polidori, G Basile, D Brischetto, S Motta, R Saponara, P Perrone, G Russo, D Del, C Car, T Pirina, S Franzoni, A Cotroneo, F Ghiggia, G Volpi, C Menichetti, M Bo, A Panico, P Calogero, G Corvalli, M Mauri, E Lupia, R Manfredini, F Fabbian, A March, M Pedrotti, M Veronesi, E Strocchi, A Bianchetti, A Crucitti, V Di Francesco, G Fontana, L Bonanni, F Barbone, C Serrati, G Ballardini, M Simoncelli, G Ceschia, C Scarpa, R Brugiolo, S Fusco, T Ciarambino, C Biagini, E Tonon, M Porta, D Venuti, M DelSette, M Poeta, G Barbagallo, G Trovato, A Delitala, P Arosio, F Reggiani, G Zuliani, B Ortolani, E Mussio, A Girardi, A Coin, G Ruotolo, A Castagna, M Masina, R Cimino, A Pinciaroli, G Tripodi, U Cannistrà, F Cassadonte, M Vatrano, F Cassandonte, L Scaglione, P Fogliacco, C Muzzuilini, F Romano, A Padovani, L Rozzini, A Cagnin, F Fragiacomo, G Desideri, E Liberatore, A Bruni, G Orsitto, M Franco, L Bonfrate, M Bonetto, N Pizio, G Magnani, G Cecchetti, A Longo, V Bubba, L Marinan, M Cotelli, M Turla, M Brunori, M Sessa, L Abruzzi, G Castoldi, D LoVetere, C Musacchio, M Novello, A Cavarape, A Bini, A Leonardi, F Seneci, W Grimaldi, F Fimognari, V Bambara, A Saitta, F Corica, M Braga, E Ettorre, C Camellini, A Marengoni, A Bruni, A Crescenzo, G Noro, R Turco, M Ponzetto, L Giuseppe, B Mazzei, G Maiuri, D Costaggiu, R Damato, E Fabbro, G Patrizia, L Santuari, M Gallucci, C Minaglia, M Paragona, P Bini, D Modica, C Abati, M Clerici, I Barbera, F NigroImperiale, A Manni, C Votino, C Castiglioni, M Di, M Degl'Innocenti, G Moscatelli, S Guerini, C Casini, D Dini, S DeNotariis, F Bonometti, C Paolillo, A Riccardi, A Tiozzo, A SamySalamaFahmy, A Riccardi, C Paolillo, M DiBari, S Vanni, A Scarpa, D Zara, P Ranieri, P Calogero, G Corvalli, D Pezzoni, S Gentile, A Morandi, C Platto, V D'Ambrosio, B Faraci, C Ivaldi, P Milia, F DeSalvo, C Solaro, M Strazzacappa, M Bo, A Panico, M Cazzadori, S Confente, M Bonetto, G Magnani, G Cecchetti, V Guerini, B Bernardini, C Corsini, S Boffelli, A Filippi, K Delpin, E Bertoletti, M Vannucci, F Tesi, P Crippa, A Malighetti, C Caltagirone, S DiSant, D Bettini, F Maltese, M Formilan, G Abruzzese, C Minaglia, D Cosimo, M Azzini, M Cazzadori, M Colombo, G Procino, S Fascendini, F Barocco, P Del, F D'Amico, A Grippa, A Mazzone, E Riva, D Dell'Acqua, M Cottino, G Vezzadini, S Avanzi, S Orini, F Sgrilli, A Mello, L Lombardi, E Muti, B Dijk, S Fenu, C Pes, P Gareri, A Castagna, M Passamonte, F De, R Rigo, L Locusta, L Caser, G Rosso, S Cesarini, R Cozzi, C Santini, P Carbone, I Cazzaniga, R Lovati, A Cantoni, P Ranzani, D Barra, G Pompilio, S Dimori, S Cernesi, C Riccò, F Piazzolla, E Capittini, C Rota, F Gottardi, L Merla, A Barelli, A Millul, G De, G Morrone, M Bigolari, C Minaglia, M Macchi, F Zambon, F D'Amico, F D'Amico, C Pizzorni, G DiCasaleto, G Menculini, M Marcacci, G Catanese, D Sprini, T DiCasalet, M Bocci, S Borga, P Caironi, C Cat, E Cingolani, L Avalli, G Greco, G Citerio, L Gandini, G Cornara, R Lerda, L Brazzi, F Simeone, M Caciorgna, D Alampi, S Francesconi, E Beck, B Antonini, K Vettoretto, M Meggiolaro, E Garofalo, A Bruni, S Notaro, R Varutti, F Bassi, G Mistraletti, A Marino, R Rona, E Rondelli, I Riva, A Scapigliati, A Cortegiani, F Vitale, L Pistidda, R D'Andrea, L Querci, P Gnesin, M Todeschini, M Lugano, G Castelli, M Ortolani, A Cotoia, S Maggiore, L DiTizio, R Graziani, I Testa, E Ferretti, C Castioni, F Lombardi, R Caserta, M Pasqua, S Simoncini, F Baccarini, M Rispoli, F Grossi, L Cancelliere, M Carnelli, F Puccini, G Biancofiore, A Siniscalchi, C Laici, E Mossello, M Torrini, G Pasetti, S Palmese, R Oggioni, V Mangani, S Pini, M Martelli, E Rigo, F Zuccalà, A Cherri, R Spina, I Calamai, N Petrucci, A Caicedo, F Ferri, P Gritti, N Brienza, R Fonnesu, M Dessena, G Fullin, D Saggioro
Subjects: Male, Aging, medicine.medical_specialty, Sarcopenia, medicine.medical_treatment, Socio-culturale, Older person, Logistic regression, Delirium, Older persons, Sarcopenia, Internal medicine, mental disorders, Delirium, Older persons, medicine, Dementia, Humans, LS4_4, Muscle, Skeletal, Pathological, Aged, Rehabilitation, business.industry, Area under the curve, Settore MED/23 - Chirurgia Cardiaca, Skeletal, medicine.disease, Skeletal muscle mass, Cross-Sectional Studies, Italy, Muscle, Female, Geriatrics and Gerontology, medicine.symptom, business
Abstract: Introduction Delirium and sarcopenia are common, although underdiagnosed, geriatric syndromes. Several pathological mechanisms can link delirium and low skeletal muscle mass, but few studies have investigated their association. We aimed to investigate (1) the association between delirium and low skeletal muscle mass and (2) the possible role of calf circumference mass in finding cases with delirium. Methods The analyses were conducted employing the cross-sectional “Delirium Day” initiative, on patient 65 years and older admitted to acute hospital medical wards, emergency departments, rehabilitation wards, nursing homes and hospices in Italy in 2017. Delirium was diagnosed as a 4 + score at the 4-AT scale. Low skeletal muscle mass was operationally defined as calf circumference ≤ 34 cm in males and ≤ 33 cm in females. Logistic regression models were used to investigate the association between low skeletal muscle mass and delirium. The discriminative ability of calf circumference was evaluated using non-parametric ROC analyses. Results A sample of 1675 patients was analyzed. In total, 73.6% of participants had low skeletal muscle mass and 24.1% exhibited delirium. Low skeletal muscle mass and delirium showed an independent association (OR: 1.50; 95% CI 1.09–2.08). In the subsample of patients without a diagnosis of dementia, the inclusion of calf circumference in a model based on age and sex significantly improved its discriminative accuracy [area under the curve (AUC) 0.69 vs 0.57, p Discussion and conclusion Low muscle mass is independently associated with delirium. In patients without a previous diagnosis of dementia, calf circumference may help to better identify those who develop delirium.
Published: 2022

46. Short-term effects of particulate matter constituents on daily hospitalizations and mortality in five South-European cities: Results from the MED-PARTICLES project

Author: Basagana X., Jacquemin B., Karanasiou A., Ostro B., Querol X., Agis D., Alessandrini E., Alguacil J., Artinano B., Catrambone M., de la Rosa J.D., Diaz J., Faustini A., Ferrari S., Forastiere F., Katsouyanni K., Linares C., Perrino C., Ranzi A., Ricciardelli I., Samoli E., Zauli-Sajani S., Sunyer J., Stafoggia M., Angelini P., Berti G., Bisanti L., Cadum E., Chiusolo M., Davoli M., de'Donato F., Demaria M., Gandini M., Grosa M., Pandolfi P., Pelosini R., Pietrodangelo A., Pizzi L., Poluzzi V., Priod G., Randi G., Rowinski M., Scarinzi C., Stivanello E., Dimakopoulou K., Elefteriadis K., Kelessis A., Maggos T., Michalopoulos N., Pateraki S., Petrakakis M., Rodopoulou S., Sypsa V., Barrera-Gomez J., delaRosa J., Fernandez R., Perez N., Pey J., Salvador P., Sanchez AM, Tobias A., Bidondo M., Declercq C., LeTertre A., Lozano P., Medina S., Pascal L., Pascal M., European Commission, Xavier Basagaña, Bénédicte Jacquemin, Angeliki Karanasiou, Bart Ostro, Xavier Querol, David Agi, Ester Alessandrini, Juan Alguacil, Begoña Artiñano, Maria Catrambone, Jesús D. de la Rosa, Julio Díaz, Annunziata Faustini, Silvia Ferrari, Francesco Forastiere, Klea Katsouyanni, Cristina Linare, Cinzia Perrino, Andrea Ranzi, Isabella Ricciardelli, Evangelia Samoli, Stefano Zauli-Sajani, Jordi Sunyer, Massimo Stafoggia, on behalf of the MED-PARTICLES Study group: […, E. Alessandrini, P. Angelini, G. Berti, L.Bisanti, E. Cadum, M. Catrambone, M. Chiusolo, M. Davoli, F. de' Donato, M. Demaria, M. Gandini, M. Grosa, A. Faustini, S. Ferrari, F. Forastiere, P. Pandolfi, R.Pelosini, C. Perrino, A. Pietrodangelo, L. Pizzi, V. Poluzzi, G.Priod, G. Randi, A. Ranzi, M. Rowinski, C.Scarinzi, M.Stafoggia, E. Stivanello, S.Zauli-Sajani, and …]
Subjects: Acute effects, Pediatrics, medicine.medical_specialty, genetic structures, Respiratory Tract Diseases, Chemical constituent, Nitrate, Air pollutants, Specie, Interquartile range, Environmental health, Cardiovascular Disease, Metals, Heavy, medicine, Humans, Cities, Particle Size, Mortality, Respiratory Tract Disease, lcsh:Environmental sciences, General Environmental Science, Cardiovascular mortality, Hospital admissions, lcsh:GE1-350, Species, Air Pollutants, Nitrates, business.industry, Sulfates, Particulates, Hospital admission, Sulfate, Citie, Total mortality, Hospitalization, Italy, Air Pollutant, Cardiovascular Diseases, Spain, Mediterranean area, Particulate Matter, business, Particulate matter, Human
Abstract: BACKGROUND: Few recent studies examined acute effects on health of individual chemical species in the particulate matter (PM) mixture, and most of them have been conducted in North America. Studies in Southern Europe are scarce. The aim of this study is to examine the relationship between particulate matter constituents and daily hospital admissions and mortality in five cities in Southern Europe. METHODS: The study included five cities in Southern Europe, three cities in Spain: Barcelona (2003-2010), Madrid (2007-2008) and Huelva (2003-2010); and two cities in Italy: Rome (2005-2007) and Bologna (2011-2013). A case-crossover design was used to link cardiovascular and respiratory hospital admissions and total, cardiovascular and respiratory mortality with a pre-defined list of 16 PM10 and PM2.5 constituents. Lags 0 to 2 were examined. City-specific results were combined by random-effects meta-analysis. RESULTS: Most of the elements studied, namely EC, SO4(2-), SiO2, Ca, Fe, Zn, Cu, Ti, Mn, V and Ni, showed increased percent changes in cardiovascular and/or respiratory hospitalizations, mainly at lags 0 and 1. The percent increase by one interquartile range (IQR) change ranged from 0.69% to 3.29%. After adjustment for total PM levels, only associations for Mn, Zn and Ni remained significant. For mortality, although positive associations were identified (Fe and Ti for total mortality; EC and Mg for cardiovascular mortality; and NO3(-) for respiratory mortality) the patterns were less clear. CONCLUSIONS: The associations found in this study reflect that several PM constituents, originating from different sources, may drive previously reported results between PM and hospital admissions in the Mediterranean area. The research described in this article was conducted under the grant agreement European Commission, Environment LIFE10/IT/327. We thank the Instituto Nacional de Estadística and the Agència de Salut Pública de Barcelona for providing the mortality data, the Consorci Sanitari de Barcelona (Cat-Salut) for providing hospitalization data for Barcelona and the Agencia Estatal de Meteorologia (Ministerio de Agricultura, Alimentación y Medio Ambiente) for providing the weather data for Spain. Sí
Published: 2015
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47. I papiri e gli ostraka greci, figurati e copti (2001-2009)

Author: CAPASSO, Mario, Capasso M, Davoli P, and Capasso, Mario
Subjects: ostraka, Soknopaiou Nesos, Papiri
Abstract: Catalogo dei papiri e degli ostraka greci rinvenuti dalla Missione Archeologica del Centro di Studi Papirologici dell'Università del Salento nel sito di epoca greco-romana di Soknopaiou Nesos (Fayyum, Egitto).
Published: 2012

48. Introduzione: Dime in età moderna

Author: CAPASSO, Mario, DAVOLI, PAOLA, Capasso M, Davoli P., Capasso, Mario, and Davoli, Paola
Subjects: Soknopaiou Neso, Dime, Studi, Età Moderna
Abstract: Introduzione sulla città di Dime, anticamente chiamata Soknopaiou Nesos, nel cui sito Archeologico scava la Missione Archeologica del Centro di Studi Papirologici dell'Università del Salento.
Published: 2012

49. Prefazione/Preface

Author: CAPASSO, Mario, Capasso M, Davoli P, and Capasso, Mario
Subjects: Soknopaiou Neso, Dime, Scavi
Abstract: Introduzione al volume sull'attività di scavo condotta dalla Missione Archeologica del Centro di Studi Papirologici dell'Università del Salento a Soknopaiou Nesos (Fayyum, Egitto) dal 2003 al 2009.
Published: 2012

50. Gli ostraka della Campagna del 2001

Author: CAPASSO, Mario, CAPASSO M, DAVOLI P, PERNIGOTTI S ED., Capasso, Mario, PERNIGOTTI S, and CAPASSO M. DAVOLI P
Published: 2002

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