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3 results on '"M, Tzagarakis"'

1. Epidural metastasis from orbital malignant fibrous histiocytoma - A case report

Author

Kaseta, M. Tzagarakis, G.P. Khaldi, L. Nikolopoulos, K. Zoubos, A.B. Korres, D.S.

Abstract

This report describes a patient complaining of low back pain and presenting with neurological symptoms that proved to be due to epidural metastasis from retroorbital malignant fibrous histiocytoma (MFH). Because of its origin, primary or metastatic MFH can appear virtually anywhere. Both imaging studies and intraoperative findings of this patient clearly demonstrated tumor in the epidural space but no involvement of vertebra. Resection of the tumor was followed by adjuvant radiotherapy, but the patient died 6 months postoperatively. On the basis of histologic examination, the tumor was diagnosed as a histiocytoma. Orbital and epidural MFH are very rare. This is the first reported case of epidural metastasis from retroorbital MFH. MFH is a highly malignant neoplasm with guarded prognosis despite treatment.

Published
2003

2. Collaborative mining and interpretation of large-scale data for biomedical research insights.

Author

Tsiliki G, Karacapilidis N, Christodoulou S, and Tzagarakis M

Subjects
Algorithms, Cooperative Behavior, Humans, Biomedical Research organization & administration, Data Mining methods, Information Dissemination, Software
Abstract

Biomedical research becomes increasingly interdisciplinary and collaborative in nature. Researchers need to efficiently and effectively collaborate and make decisions by meaningfully assembling, mining and analyzing available large-scale volumes of complex multi-faceted data residing in different sources. In line with related research directives revealing that, in spite of the recent advances in data mining and computational analysis, humans can easily detect patterns which computer algorithms may have difficulty in finding, this paper reports on the practical use of an innovative web-based collaboration support platform in a biomedical research context. Arguing that dealing with data-intensive and cognitively complex settings is not a technical problem alone, the proposed platform adopts a hybrid approach that builds on the synergy between machine and human intelligence to facilitate the underlying sense-making and decision making processes. User experience shows that the platform enables more informed and quicker decisions, by displaying the aggregated information according to their needs, while also exploiting the associated human intelligence.

Published
2014
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3. Association between squamous cell carcinoma of the head and neck and serum folate and homocysteine.

Author

Eleftheriadou A, Chalastras T, Ferekidou E, Yiotakis I, Kyriou L, Tzagarakis M, Ferekidis E, and Kandiloros D

Subjects
Aged, Carcinoma, Squamous Cell pathology, Female, Head and Neck Neoplasms pathology, Humans, Hyperhomocysteinemia blood, Hyperhomocysteinemia complications, Male, Middle Aged, Neoplasm Staging, Prospective Studies, Smoking blood, Carcinoma, Squamous Cell blood, Folic Acid blood, Head and Neck Neoplasms blood, Homocysteine blood
Abstract

Unlabelled: The aim of this study was to evaluate the serum levels of folate and homocysteine in patients with squamous cell carcinoma of the head and neck (SCCHN) and to correlate them with the clinical stage. An attempt was made to associate the results with the effects of smoking., Materials and Methods: Serum levels of folate and homocysteine were measured in 150 patients with histologically-proven SCCHN before any treatment and in 150 healthy volunteers (77 smokers and 73 nonsmokers)., Results: The study indicated a positive correlation between hyperhomocysteinemia and hypofolatemia and the presence of SCCHN. Folate deficiency and high levels of homocysteine were noted in a large number of healthy smokers., Conclusion: If metabolic disorders of the methionine cycle are confirmed as risk factors for SCCHN, folate as a dietary supplement might play a role in chemoprevention and the posttreatment care of SCCHN patients.

Published
2006

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