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1. Association of leptin receptor gene Gln223Arg polymorphism with insulin resistance and hyperglycemia in patients with metabolic syndrome.

Author

Mirrakhimov, Erkin, Bektasheva, Erkaiym, Isakova, Jainagul, Lunegova, Olga, Kerimkulova, Alina, Abilova, Saamay, Neronova, Ksenya, Alibaeva, Nazira, Mamatuulu, Yrysbek U., Kudaibergenova, Indira, Banach, Maciej, and Mirrakhimov, Aibek

Subjects
LEPTIN receptors, INSULIN resistance, METABOLIC syndrome, GENETIC polymorphisms, HYPERGLYCEMIA, GENETIC markers
Abstract

Introduction: Worldwide, there has been an increase in the incidence of metabolic syndrome. The search for genetic markers of this syndrome is ongoing. The leptin receptor has recently received attention. One of the polymorphisms (Gln223Arg) is possibly associated with the development of obesity and insulin resistance. However, the results of studies on this polymorphism remain equivocal. Gln223Arg polymorphism has not been studied previously in the Kyrgyz population. Thus, we aimed to investigate the possible association of the Gln223Arg polymorphism of the leptin receptor gene with metabolic syndrome components in the Kyrgyz population. Material and methods: 237 Kyrgyz subjects, aged 35-70 years, were studied. For the analysis anthropometric data, glucose, insulin, lipid spectrum, leptin were obtained. The genotype of the Gln223Arg leptin polymorphism was evaluated using TaqMan real-time PCR. Results: The distribution of genotypes was as follows: Gln223Gln 46.4%, Gln223Arg 40.1%, Arg223Arg 13.5%. In the study no association was found with abdominal obesity, arterial hypertension, hypertriglyceridemia or low-density cholesterol levels. Relationships of Gln223Arg and Arg223Arg genotypes with insulin resistance (p < 0.03) were found. Gln223Arg polymorphism was associated with a higher level of glycemia (5.54 vs. 5.39 mmol/l, p < 0.05) and insulinemia (8.3 vs. 7.1 µIU/ml, p < 0.05). Correlation analysis showed that carriers of the Arg223 allele demonstrated a higher risk of insulin resistance (odds ratio (OR) = 1.83, 95% CI: 1.03-3.24; p < 0.03) than carriers of the Gln223 allele. Conclusions: Gln223Arg polymorphism of the leptin receptor gene may be a marker of predisposition to insulin resistance in the Kyrgyz population. Further studies are necessary to confirm these results in populations from other regions. [ABSTRACT FROM AUTHOR]

Published
2024
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3. May Measurement Month 2019: analysis of blood pressure screening in Bishkek, Kyrgyzstan

Author

Mirrakhimov, Erkin, primary, Zakirov, Umid, additional, Abilova, Saamay, additional, Asanbaev, Azamat, additional, Bektasheva, Erkaiym, additional, Asanaliev, Nursultan, additional, uulu, Yrysbek Mamat, additional, Alibaeva, Nazira, additional, Neronova, Ksenya, additional, Kerimkulova, Alina, additional, Lunegova, Olga, additional, Altymysheva, Aliina, additional, Wang, Wei, additional, Beaney, Thomas, additional, and Poulter, Neil R, additional

Published
2022
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4. 2019 ESC Guidelines for the management of patients with supraventricular tachycardiaThe Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)

Author

Brugada, Josep, Katritsis, Demosthenes, Arbelo, Elena, Arribas, Fernando, Bax, Jeroen, Blomström-Lundqvist, Carina, Calkins, Hugh, Corrado, Domenico, Deftereos, Spyridon, Diller, Gerhard-Paul, Gomez-Doblas, Juan, Gorenek, Bulent, Grace, Andrew, Ho, Siew Yen, Kaski, Juan-Carlos, Kuck, Karl-Heinz, Lambiase, Pier David, Sacher, Frederic, Sarquella-Brugada, Georgia, Suwalski, Piotr, Zaza, Antonio, De Potter, Tom, Sticherling, Christian, Basso, Cristina, Bocchiardo, Mario, Budts, Werner, Dobrev, Dobromir, Gevaert, Sofie, Heidbuchel, Hein, Kanagaratnam, Prapa, Kriebel, Thomas, Lancellotti, Patrizio, Lopatin, Yury, Merkely, Béla, Paul, Thomas, Pavlović, Nikola, Potpara, Tatjana, Scherr, Daniel, Zeppenfeld, Katja, Windecker, Stephan, Aboyans, Victor, Baigent, Colin, Collet, Jean-Philippe, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gale, Chris, Grobbee, Diederick, Halvorsen, Sigrun, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo, Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil, Merkely, Bela, Mueller, Christian, Petersen, Steffen, Petronio, Anna Sonia, Richter, Dimitrios, Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain, Sousa-Uva, Miguel, Touyz, Rhian, Amara, Walid, Grigoryan, Svetlana, Podczeck-Schweighofer, Andrea, Chasnoits, Alexandr, Vandekerckhove, Yves, Sokolovich, Sekib, Traykov, Vassil, Skoric, Bosko, Papasavvas, Elias, Kautzner, Josef, Riahi, Sam, Kampus, Priit, Parikka, Hannu, Piot, Olivier, Etsadashvili, Kakhaber, STELLBRINK, CHRISTOPH, Manolis, Antonis, Csanádi, Zoltán, Gudmundsson, Kristjan, Erwin, John, Barsheshet, Alon, De Ponti, Roberto, Abdrakhmanov, Ayan, Jashari, Haki, Lunegova, Olga, Jubele, Kristine, Refaat, Marwan, Puodziukynas, Aras, Groben, Laurent, Grosu, Aurel, Pavlovic, Nikola, Ibtissam, Fellat, Trines, Serge, Poposka, Lidija, Haugaa, Kristina, Kowalski, Oskar, Cavaco, Diogo, Dobreanu, Dan, Mikhaylov, Evgeny, Zavatta, Marco, Nebojša, Mujović, Hlivak, Peter, Ferreira-Gonzalez, Ignacio, Juhlin, Tord, Reichlin, Tobias, Haouala, Habib, Akgun, Taylan, Gupta, Dhiraj, IHU-LIRYC, and Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]

Subjects
Tachycardia, pre-excitation, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, focal, [SDV]Life Sciences [q-bio], Cardiology, Guidelines, 030204 cardiovascular system & hematology, tachycardia, arrhythmia, ablation, atrioventricular, flutter, junctional, macro–re-entrant, nodal, re-entrant, supraventricular, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Tachycardia, Supraventricular, medicine, Humans, cardiovascular diseases, ComputingMilieux_MISCELLANEOUS, reproductive and urinary physiology, Task force, business.industry, Arrhythmias, Cardiac, 030229 sport sciences, medicine.disease, 3. Good health, EBSTEIN ANOMALY, embryonic structures, Emergency medicine, Catheter Ablation, cardiovascular system, Re entrant, Supraventricular tachycardia, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

2019 ESC Guidelines for the management of patients with supraventricular tachycardia : The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC): Developed in collaboration with the Association for European Paediatric and Congenital Cardiology (AEPC)

Published
2019
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5. 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS)

Author

Aboyans, Victor, Ricco, Jean-Baptiste, Bartelink, Marie-Louise E. L., Björck, Martin, Brodmann, Marianne, Cohnert, Tina, Collet, Jean-Philippe, Czerny, Martin, De Carlo, Marco, Debus, Sebastian, Espinola-Klein, Christine, Kahan, Thomas, Kownator, Serge, Mazzolai, Lucia, Naylor, A Ross, Roffi, Marco, Röther, Joachim, Sprynger, Muriel, Tendera, Michal, Tepe, Gunnar, Venermo, Maarit, Vlachopoulos, Charalambos, Desormais, Ileana, Widimsky, Petr, Kolh, Philippe, Agewall, Stefan, Bueno, Héctor, Coca, Antonio, De Borst, Gert J., Delgado, Victoria, Dick, Florian, Erol, Cetin, Ferrini, Marc, Kakkos, Stavros, Katus, Hugo A., Knuuti, Juhani, Lindholt, Jes, Mattle, Heinrich, Pieniazek, Piotr, Piepoli, Massimo Francesco, Scheinert, Dierk, Sievert, Horst, Simpson, Iain, Sulzenko, Jakub, Tamargo, Juan, Tokgozoglu, Lale, Torbicki, Adam, Tsakountakis, Nikolaos, Tuñón, José, De Ceniga, Melina Vega, Windecker, Stephan, Zamorano, Jose Luis, Barbato, Emanuele, Coman, Ioan Mircea, Dean, Veronica, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Juni, Peter, Lancellotti, Patrizio, Leclercq, Christophe, McDonagh, Theresa, Ponikowski, Piotr, Richter, Dimitrios J., Shlyakhto, Evgeny, Simpson, Iain A., Zelveian, Parounak H., Haumer, Markus, Isachkin, Dzmitry, De Backer, Tine, Dilic, Mirza, Petrov, Ivo, Kirhmajer, Majda Vrkic, Karetova, Debora, Prescott, Eva, Soliman, Hamdy, Paapstel, Ants, Makinen, Kimmo, Tosev, Slavco, Messas, Emmanuel, Pagava, Zurab, Müller, Oliver J., Naka, Katerina K., Járai, Zoltán, Gudjonsson, Thorbjorn, Jonas, Michael, Novo, Salvatore, Ibrahimi, Pranvera, Lunegova, Olga, Dzerve, Vilnis, Misonis, Nerijus, Beissel, Jean, Pllaha, Elton, Taberkant, Mustapha, Bakken, Torbjørn, Teles, Rui, Lighezan, Daniel, Konradi, Alexandra, Zavatta, Marco, Madaric, Juraj, Fras, Zlatko, Melchor, Lorenzo Silva, Näslund, Ulf, Amann-Vesti, Beatrice, Obiekezie, Agu, Aboyans, Victor, Ricco, Jean-Baptiste, Bartelink, Marie-Louise E.L., Björck, Martin, Brodmann, Marianne, Cohnert, Tina, Collet, Jean-Philippe, Czerny, Martin, De Carlo, Marco, Debus, Sebastian, Espinola-Klein, Christine, Kahan, Thoma, Kownator, Serge, Mazzolai, Lucia, Naylor, A Ro, Roffi, Marco, Röther, Joachim, Sprynger, Muriel, Tendera, Michal, Tepe, Gunnar, Venermo, Maarit, Vlachopoulos, Charalambo, Desormais, Ileana, Widimsky, Petr, Kolh, Philippe, Agewall, Stefan, Bueno, Héctor, Coca, Antonio, De Borst, Gert J., Delgado, Victoria, Dick, Florian, Erol, Cetin, Ferrini, Marc, Kakkos, Stavro, Katus, Hugo A., Knuuti, Juhani, Lindholt, Je, Mattle, Heinrich, Pieniazek, Piotr, Piepoli, Massimo Francesco, Scheinert, Dierk, Sievert, Horst, Simpson, Iain, Sulzenko, Jakub, Tamargo, Juan, Tokgozoglu, Lale, Torbicki, Adam, Tsakountakis, Nikolao, Tuñón, José, De Ceniga, Melina Vega, Windecker, Stephan, Zamorano, Jose Lui, Barbato, Emanuele, Coman, Ioan Mircea, Dean, Veronica, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Juni, Peter, Lancellotti, Patrizio, Leclercq, Christophe, McDonagh, Theresa, Ponikowski, Piotr, Richter, Dimitrios J., Shlyakhto, Evgeny, Simpson, Iain A., Zelveian, Parounak H., Haumer, Marku, Isachkin, Dzmitry, De Backer, Tine, Dilic, Mirza, Petrov, Ivo, Kirhmajer, Majda Vrkic, Karetova, Debora, Prescott, Eva, Soliman, Hamdy, Paapstel, Ant, Makinen, Kimmo, Tosev, Slavco, Messas, Emmanuel, Pagava, Zurab, Müller, Oliver J., Naka, Katerina K., Járai, Zoltán, Gudjonsson, Thorbjorn, Jonas, Michael, Novo, Salvatore, Ibrahimi, Pranvera, Lunegova, Olga, Dzerve, Vilni, Misonis, Neriju, Beissel, Jean, Pllaha, Elton, Taberkant, Mustapha, Bakken, Torbjørn, Teles, Rui, Lighezan, Daniel, Konradi, Alexandra, Zavatta, Marco, Madaric, Juraj, Fras, Zlatko, Melchor, Lorenzo Silva, Näslund, Ulf, Amann-Vesti, Beatrice, and Obiekezie, Agu

Subjects
medicine.medical_specialty, Carotid artery disease, business.industry, Atherosclerotic disease, Upper extremity artery disease, Guideline, 030204 cardiovascular system & hematology, Vascular surgery, Lower extremity artery disease, Multisite artery disease, Peripheral Arterial Diseases, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Renal artery disease, Internal medicine, Peripheral arterial disease, medicine, Cardiology, Mesenteric artery disease, 030212 general & internal medicine, Vertebral artery disease, Cardiology and Cardiovascular Medicine, business
Abstract

2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS) : Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries

Published
2017
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8. Cut off values for abdominal obesity as a criterion of metabolic syndrome in an ethnic Kyrgyz population (Central Asian region)

Author

Mirrakhimov Aibek E, Lunegova Olga S, Kerimkulova Alina S, Moldokeeva Cholpon B, Nabiev Malik P, and Mirrakhimov Erkin M

Subjects
Obesity, Abdominal obesity, Waist circumference insulin resistance, Metabolic syndrome, Cardiovascular risk, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background People of different racial and ethnic backgrounds have a distinct pattern of central fat deposition, thus making it necessary to devise a race based approach for the diagnosis and evaluation of abdominal obesity (AO). This is the first study to determine the optimal waist circumference (WC) cutoff values for definition of AO in an ethnic Kyrgyz population. Methods 323 persons of Kyrgyz ethnicity (183 women and 140 men), with a mean age of 51.8 ± 9.5 years old were included in the study. Measurement of blood pressure (BP), anthropometric data (including body mass index calculation and WC measurement), fasting blood sugar, serum lipid parameters and insulin were performed in all examined individuals. Insulin resistance (IR) was considered as HOMA index (insulin × fasting glucose/22.5) ≥ 2.77. Sensitivity and specificity for the presence of IR or two other criteria of MS (according to the international classification, 2009) were calculated by using receiver operating characteristic (ROC) curves for men and women separately. Results The optimal sensitivity and specificity obtained from the ROC curves for IR were 88 cm in women (sensitivity of 0.85, 95%CI (0.72-0.93), specificity of 0.58, 95%CI (0.49-0.66)) and 94 cm for men (sensitivity of 0.8, 95% CI (0.65-0.91), specificity of 0.61, 95% CI (0.51-0.71)). The data from the ROC curve for any two other MS criteria confirmed the results and the WC 88 cm in women (sensitivity of 0.82, 95% CI (0.72-0.9), specificity of 0.72, 95% CI (0.62-0.8)) and 94 cm in men (sensitivity of 0.74, 95% CI (0.62-0.84), specificity of 0.73, 95% CI (0.61-0.83)) were corresponded to the optimal sensitivity and specificity. Conclusion WC ≥ 88 cm and ≥ 94 cm should be used as a criterion for the diagnosis of AO for Kyrgyz women and men respectively based on these results.

Published
2012
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9. 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS)

Author

Ricco, Jean-Baptiste, Bartelink, Marie-Louise, Björck, Martin, Brodmann, Marianne, Cohnert, Tina, Czerny, Martin, De Carlo, Marco, Debus, Sebastian, Espinola-Klein, Christine, Kahan, Thomas, Kownator, Serge, Mazzolai, Lucia, Naylor, A Ross, Röther, Joachim, Sprynger, Muriel, Tendera, Michal, Tepe, Gunnar, Venermo, Maarit, Vlachopoulos, Charalambos, Desormais, Iléana, Widimsky, Petr, Kolh, Philippe, De Borst, Gert, Dick, Florian, Erol, Cetin, Ferrini, Marc, Kakkos, Stavros, Lindholt, Jes, Mattle, Heinrich, Pieniazek, Piotr, Scheinert, Dierk, Sievert, Horst, Sulzenko, Jakub, Tamargo, Juan, Tokgözoglu, Lale, Torbicki, Adam, Tsakountakis, Nikolaos, Tuñón, José, de Ceniga, Melina Vega, Windecker, Stephan, Aboyans, Victor, Agewall, Stefan, Barbato, Emanuele, Bueno, Hector, Coca, Antonio, Collet, Jean-Philippe, Coman, Ioan Mircea, Dean, Veronica, Delgado, Victor, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo, Knuuti, Juhani, Lancellotti, Patrizio, Leclercq, Christophe, Mcdonagh, Theresa, Piepoli, Massimo Francesco, Ponikowski, Piotr, Richter, Dimitrios, Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain, Zamorano, Jose Luis, Zelveian, Parounak, Haumer, Markus, Isachkin, Dzmitry, De Backer, Tine, Dilic, Mirza, Petrov, Petr, Kirhmajer, Majda Vrkic, Karetova, Debora, Prescott, Eva, Soliman, Hamdy, Paapstel, Ants, Makinen, Kimmo, Tosev, Slavco, Messas, Emmanuel, Pagava, Zurab, Müller, Oliver, Naka, Katerina, Járai, Zoltán, Gudjonsson, Thorbjorn, Jonas, Michael, Novo, Salvatore, Ibrahimi, Pranvera, Lunegova, Olga, Dzerve, Vilnis, Misonis, Nerijus, Beissel, Jean, Pllaha, Elton, Taberkant, Mustapha, Bakken, Torbjørn, Teles, Rui, Lighezan, Daniel, Konradi, Alexandra, Zavatta, Marco, Madaric, Juraj, Fras, Zlatko, Melchor, Lorenzo Silva, Näslund, Ulf, Amann-Vesti, Beatrice, Obiekezie, Agu, Service de cardiologie [CHU de Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Julius Centre for Health Sciences and Primary Health Care, Department of Internal Medicine, Medizinische Universität Graz, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet [Stockholm], Department of Neurology, Asklepios Klinik Altona, Centre Hospitalier Universitaire de Liège (CHU-Liège), Third Division of Cardiology, Medical University of Silesia (SUM), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Hacettepe University = Hacettepe Üniversitesi, Karolinska Institute, karolinska institute, 'Federico II' University of Naples Medical School, Hospital General Universitario 'Gregorio Marañón' [Madrid], Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CHU de Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), St. Michael's Hospital, Heidelberg University Hospital [Heidelberg], Turku PET Centre, University of Turku, Wroclaw Medical University, Universidad de Alcalá - University of Alcalá (UAH), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Michaelid Cardiac Ctr, University of Ioannina, Medical University of Silesia, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Européen Georges Pompidou [APHP] (HEGP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

10. An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

Author

Abilova Samai S, Zalesskaya Yulia V, Moldokeeva Cholpon B, Lunegova Olga S, Kerimkulova Alina S, Mirrakhimov Aibek E, Sovhozova Nurmira A, Aldashev Almaz A, and Mirrakhimov Erkin M

Subjects
metabolic syndrome, B adrenoreceptors, Trp64Arg polymorphism, abdominal obesity, dyslipidemia, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Backgrounds B3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic abnormalities in the setting of modern sedentary lifestyle. ADRB3 gene polymorphism association with metabolic disturbances has never been studied before in the ethnic Kyrgyz population. Aim To study an association between Trp64Arg polymorphism of the ADRB3 and metabolic syndrome (MS) components in an ethnic Kyrgyz group. Materials and methods 213 Ethnic Kyrgyz volunteers over the age of 30 were enrolled in the study. The assessment plan for each individual comprised of general physical and anthropometric exams as well as laboratory tests (glucose, lipid panel, insulin) and genotyping by Trp64Arg polymorphism of the ADRB3. MS diagnosis was consistent with modified ATP III criteria (2005). Logistic regression analysis was performed to test the potential independent association between Arg64 allele with obesity, abdominal obesity (AO) and arterial hypertension (AH). Results Trp64Arg polymorphism of the ADRB3 was assessed in 213 individuals (145 men, 68 women) aged 30-73 (mean age 50.7 ± 7.6). Arg64 allele frequency was 0.239; ADRB3 genotype distribution among participants was: Trp64 homozygotes 54.5%, Trp64Arg 43.2% and Arg64 homozygotes 2.3%. There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03). The logistic regression analysis showed the correlation of the Arg64 allele with obesity (OR 3.159; 95% CI 1.789-5.577) and AO (OR 1.973; 95% CI 1.118-3.481). The association between Arg64 allele and AH lost its significance after adjustment for obesity. Conclusion Arg64 allele of the ADRB3 gene in the studied group has an association with MS components such as obesity, AO and decreased HDL-C level.

Published
2011
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12. The prevalence of major cardiovascular risk factors in a rural population of the Chui region of Kyrgyzstan: The results of an epidemiological study.

Author

Polupanov, Andrey G., Khalmatov, Abdimetalib N., Altymysheva, Alina T., Lunegova, Olga S., Mirrakhimov, Aibek E., Sabirov, Ibragim S., Kontsevaya, Anna V., Dzhumagulova, Aynagul S., and Mirrakhimov, Erkin M.

Subjects
CARDIOVASCULAR diseases risk factors, RURAL population, LIPID metabolism disorders, BLOOD pressure, WAIST circumference
Abstract

Objective: To study the prevalence of cardiovascular (CV) risk factors (RFs) in the rural population of the Chui region of Kyrgyzstan (Central Asia). Methods: The sample was representative of the population in terms of age and sex and included at least 10% of the population aged 18-65 y. Of the 1,672 people included in the cohort, 1.330 people responded to the invitation (79.5% of the total sample population). All study participants were interviewed using standardized questionnaires and examined by a cardiologist. Blood pressure (BP), weight, height, waist circumference (WC), fasting serum glucose, and fasting lipid level were measured. Results: The prevalence of major CV RFs in the examined sample was as follows: arterial hypertension 34.1%, obesity 25.7%, and abdominal obesity 52.3%; the factors were significantly more prevalent in women (68.2%) and increased with age. The frequency of lipid metabolism disorders was 88.4% in the examined subjects, and an increased level of low-density cholesterol (70.5%) was common. Hypodynamia was detected in 15.6% of the subjects, diabetes mellitus in 3.76%, and a family history of cardiovascular disease was present in 34.8% of the examined subjects. The frequency of smoking was 24.6% and was significantly higher in men (46.9%). Conclusion: Abdominal obesity, followed by hypercholesterolemia and arterial hypertension were the most common RFs among the rural population of the Chui region of Kyrgyzstan. Smoking was the most common RF among men. The prevalence of traditional CV RFs, except smoking, increased with age. [ABSTRACT FROM AUTHOR]

Published
2020
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13. Frequency of C825T G protein β3 subunit gene polymorphism and its association with obesity in the Kyrgyz population

Author

Mirrakhimov Erkin, Lunegova Olga, Mirrakhimov Aibek, Zalesskaya Yuliya, Aldashev Almaz, Kerimkulova Alina, Abilova Saamai, Nabiev Malik, Alibaeva Nazira, and Starov Nurdin

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Population, Public Health, Environmental and Occupational Health, Type 2 diabetes, Odds ratio, medicine.disease, Obesity, Genotype frequency, Endocrinology, Polymorphism (computer science), Internal medicine, Genotype, medicine, Gene polymorphism, Family Practice, education, business
Abstract

Objective: To examine the frequency of C825T G protein β3 subunit gene polymorphism and its association with obesity of ethnic Kyrgyz. Methods: The study enrolled 210 people, 89 patients (35 females, 54 males) with obesity (BMI ≥ 30 kg/m2) and 121 practically healthy patients (38 females, 83 males) with normal body weight and no signs of type 2 diabetes (group of control), who were not observed before by a cardiologist. The blood pressure, anthropometry, glucose and lipid profile were examined among all subjects. Ge - nomic DNA was extracted from peripheral blood cells. G protein β3 subunit C825T polymorphism was determined by polymerase chain reaction (PCR). Results: TT and CT genotypes carriers were grouped together in one group because the TT genotype was rare. CT + TT genotype frequency in the group with obesity made 0.72 and was sig- nificantly higher than that in the control group - 0.52 (χ2-8.44; P = 0.004; odds ratio - 2.55; 95%CI 1.31-4.23). The statistical analysis revealed that hypertension (45% vs. 31.3%, P = 0.049) and obe- sity (51.2% vs. 30%, P

Published
2013
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16. The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population.

Author

Mirrakhimov, Erkin M., Kerimkulova, Alina S., Lunegova, Olga S, Mirrakhimov, Aibek E, Nabiev, Malik P., Neronova, Kseniya V., Bayramukova, Asiyat A., Alibaeva, Nazira T., and Satarov, Nurdin

Subjects
LEPTIN, HORMONES, NUTRITION disorders, OBESITY, TYPE 2 diabetes, ANALYSIS of variance
Abstract

Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ⩾30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. [ABSTRACT FROM AUTHOR]

Published
2014
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17. Influence of one-year treatment with lovastatin on myocardial remodeling and ischemia in patients with coronary artery disease.

Author

Kerimkulova, Alina, Noruzbaeva, Aygul, Lunegova, Olga, Gotfrid, Irina, Mirrakhimov, Aybek, Davydova, Nailya, Moldokeeva, Cholpon, and Mirrakhimov, Erkin

Subjects
STATINS (Cardiovascular agents), CORONARY disease, ISCHEMIA, ELECTROCARDIOGRAPHY, AMINOTRANSFERASES, T-test (Statistics), PATIENTS
Abstract

Copyright of Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011
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