10 results on '"Luczy J"'
Search Results
2. One-stage surgical approach to coarctation of the aorta and ascending aortic aneurysm
- Author
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Sabol, F., primary, Mistrikova, L., additional, Kolesar, A., additional, Luczy, J., additional, Toporcer, T., additional, and Beres, A., additional
- Published
- 2014
- Full Text
- View/download PDF
3. Hybrid repair of aortic arch aneurysm
- Author
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Sabol, F., Bily, B., Kolesar, A., Artemiou, P., Spak, L., and Luczy, J.
- Published
- 2014
- Full Text
- View/download PDF
4. The possible role of machine learning in detection of increased cardiovascular risk patients - KSC MR Study (design).
- Author
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Pella D, Toth S, Paralic J, Gonsorcik J, Fedacko J, Jarcuska P, Pella D, Pella Z, Sabol F, Jankajova M, Valocik G, Putrya A, Kirschová A, Plachy L, Rabajdova M, Hunavy M, Kafkova B, Doci I, Timkova S, Dvorožňáková M, Babic F, Butka P, Dimunova L, Marekova M, Paralicova Z, Majernik J, Luczy J, Janosik J, and Kmec M
- Abstract
Introduction: Currently, just a few major parameters are used for cardiovascular (CV) risk quantification to identify many of the high-risk subjects; however, they leave a lot of them with an underestimated level of CV risk which does not reflect the reality., Material and Methods: The submitted study design of the Kosice Selective Coronarography Multiple Risk (KSC MR) Study will use computer analysis of coronary angiography results of admitted patients along with broad patients' characteristics based on questionnaires, physical findings, laboratory and many other examinations., Results: Obtained data will undergo machine learning protocols with the aim of developing algorithms which will include all available parameters and accurately calculate the probability of coronary artery disease., Conclusions: The KSC MR study results, if positive, could establisha base for development of proper software for revealing high-risk patients, as well as patients with suggested positive coronary angiography findings, based on the principles of personalised medicine., Competing Interests: The authors declare no conflict of interest., (Copyright: © 2020 Termedia & Banach.)
- Published
- 2020
- Full Text
- View/download PDF
5. Genistein Improves Skin Flap Viability in Rats: A Preliminary In Vivo and In Vitro Investigation.
- Author
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Fáber L, Kováč I, Mitrengová P, Novotný M, Varinská L, Vasilenko T, Kello M, Čoma M, Kuruc T, Petrová K, Miláčková I, Kuczmannová A, Peržeľová V, Mižáková Š, Dosedla E, Sabol F, Luczy J, Nagy M, Majerník J, Koščo M, Mučaji P, and Gál P
- Subjects
- Animals, Cell Survival, Endothelial Cells drug effects, Endothelial Cells metabolism, Gene Expression Profiling, Gene Expression Regulation drug effects, Genistein pharmacology, Human Umbilical Vein Endothelial Cells, Humans, Models, Animal, Rats, Time Factors, Up-Regulation, Endothelial Cells cytology, Genistein administration & dosage, Proto-Oncogene Proteins c-bcl-2 metabolism, Superoxide Dismutase metabolism, Surgical Flaps physiology
- Abstract
Selective estrogen receptor modulators (SERMs) have been developed to achieve beneficial effects of estrogens while minimizing their side effects. In this context, we decided to evaluate the protective effect of genistein, a natural SERM, on skin flap viability in rats and in a series of in vitro experiments on endothelial cells (migration, proliferation, antioxidant properties, and gene expression profiling following genistein treatment). Our results showed that administration of genistein increased skin flap viability, but importantly, the difference is only significant when treatment is started 3 days prior the flap surgery. Based on our in vitro experiments, it may be hypothesized that the underlying mechanism may rather by mediated by increasing SOD activity and Bcl-2 expression. The gene expression profiling further revealed 9 up-regulated genes (angiogenesis/inflammation promoting: CTGF, CXCL5, IL-6, ITGB3, MMP-14, and VEGF-A; angiogenesis inhibiting: COL18A1, TIMP-2, and TIMP-3). In conclusion, we observed a protective effect of genistein on skin flap viability which could be potentially applied in plastic surgery to women undergoing a reconstructive and/or plastic intervention. Nevertheless, further research is needed to explain the exact underlying mechanism and to find the optimal treatment protocol., Competing Interests: The authors declare no conflict of interest.
- Published
- 2018
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6. Aortic Valve Repair of a Stenotic Unicuspid Aortic Valve in Young Patients.
- Author
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Kolesar A, Toporcer T, Bajmoczi M, Luczy J, Candik P, and Sabol F
- Subjects
- Adult, Age Factors, Animals, Aortic Valve surgery, Aortic Valve Insufficiency etiology, Aortic Valve Stenosis etiology, Bicuspid Aortic Valve Disease, Cohort Studies, Female, Heart Defects, Congenital complications, Heart Valve Diseases complications, Horses, Humans, Male, Pericardium, Treatment Outcome, Young Adult, Aortic Valve Insufficiency surgery, Aortic Valve Stenosis surgery, Bioprosthesis, Heart Defects, Congenital surgery, Heart Valve Diseases surgery, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation
- Abstract
Background: The unicuspid aortic valve (UAV) is a well-described pediatric congenital abnormality, with incidence of 0.02% in the general population. Bicuspidization has been described as a potential surgical option to repair this defect., Methods: Seventeen symptomatic young patients with a unicuspid valve combined with either valve insufficiency or valve stenosis underwent aortic valve (AV) bicuspidization procedure by using an equine pericardium. In addition to bicuspidization, 8 patients underwent aortic ring implantation and 5 patients underwent supracoronary replacement of the aorta., Results: Our results show safety of the bicuspidization procedure. No deaths occurred during our average follow-up period of 26 months. Freedom from reoperation for any valve-related reason was 100% during this follow-up period. We observed a statistically significant increase in the AV area from 0.8 ± 0.1 cm
2 to 2.8 ± 0.7 cm2 (p < 0.01), a statistically significant decrease in the mean systolic pressure gradient from 36 ± 13.3 mm Hg to 9 ± 4 mm Hg (p < 0.001), a statistically significant decrease in aortic insufficiency grade from 2.1 ± 1.0 to 0.6 ± 0.7 (p < 0.01) before and after bicuspidization, respectively, and a statistically significant decrease in the left ventricular end-diastolic diameter from 49.88 ± 5.11 mm to 40.46 ± 7.20 mm (p < 0.0005) and a statistically significant increase of the left ventricular ejection fraction from 56% ± 8.20% to 64% ± 7.83% at the time of follow-up., Conclusions: From our study, bicuspidization is an attractive surgical option to repair UAV, particularly in young patients who do not want to be subjected to long-term anticoagulation therapy or who refuse a more traditional surgical approach, such as Ross procedure, for reasons described previously., (Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)- Published
- 2018
- Full Text
- View/download PDF
7. "V" aortoplasty of the proximal descending aorta in the elephant trunk procedure.
- Author
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Kolesar A, Bily B, Spak L, Luczy J, Artemiou P, and Sabol F
- Subjects
- Aorta surgery, Aorta, Thoracic diagnostic imaging, Aortic Aneurysm diagnostic imaging, Female, Humans, Middle Aged, Stents, Tomography, X-Ray Computed, Vascular Surgical Procedures methods, Aorta, Thoracic surgery, Aortic Aneurysm surgery
- Abstract
Complex pathology of the aorta, especially in patients presenting an aneurysm involving the entire aortic arch and proximal descending aorta has been approached in one or two stages. Surgical management of those with an extremely wide diameter of the proximal descending aorta is not yet well defined. The patient in this case was an asymptomatic 47-year-old female with systemic lupus erythematosus (SLE) associated with aneurysm of the ascending aorta, whose aortic arch and descending aorta had presented only overall weakness (examination by inspection and palpation without histological verification). The imaging identified a giant aorta arising at the level of the sinotubular junction (STJ), ending up immediately below the diaphragm. In the first stage she underwent surgical replacement of the entire ascending aorta, aortic arch and proximal part of the descending aorta by combining the elephant trunk with a new type of aortoplasty. In the second stage an endovascular stent graft was inserted into the elephant trunk in the descending aorta. The patient continues to do well 20 months following the repair. In this manuscript type we describe a novel technique of "V" aortoplasty of the proximal descending aorta in order to facilitate the performing of anastomosis between the Dacron graft and aortic aneurysm.
- Published
- 2015
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8. Aortic valve-sparing operation versus Bentall and mechanical aortic valve replacement--midterm results.
- Author
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Sabol F, Kolesar A, Jankajova M, Luczy J, Holoubek D, Artemiou P, Toporcer T, Jevcakova J, Valocik G, Porubcinova I, Dvoroznakova M, Candik P, Jakubova M, Torok P, Beres A, Mistrikova L, Safar P, and Ledecky M
- Subjects
- Aortic Dissection mortality, Aortic Aneurysm mortality, Aortic Valve Insufficiency mortality, Female, Hospital Mortality, Humans, Male, Middle Aged, Postoperative Complications mortality, Reoperation, Retrospective Studies, Treatment Outcome, Aortic Dissection surgery, Aortic Aneurysm surgery, Aortic Valve Insufficiency surgery, Heart Valve Prosthesis Implantation methods
- Abstract
Objectives: The primary aim of this retrospective study was to evaluate short-term (one-to-six months) and mid-term (six-to-forty-eight months) results of aortic valve-sparing procedures. The second endpoint was to compare the results with the group of patients undergoing mechanical aortic valve replacement during the same period., Methods: Between April 2008 and May 2012 at our institution, we treated 76 patients either with ascending aorta/root aneurysm/dissection or with isolated aortic regurgitation. A total of seventy-six patients undergoing aortic valve surgery., Results: Analyzed parameters were divided into two parts as function of time. In the first part, i.e. during hospitalization, the mortality, duration of hospitalization, duration of extra corporeal circulation (ECC), and duration of cardiac arrest (CA) were compared and assessed. In the second part, i.e. during monitoring of the patients after their discharge from hospital (one-to-six months, and six-to-forty-eight months), the grade of postoperative AR aimed mainly at the group of aortic valve-sparing operations (subgroups A1, A2, A3), postoperative peak gradient, presence of thromboembolic and bleeding complications, postoperative endocarditis and need for reoperation or hospitalization due to cardiac reasons were analyzed., Conclusion: Based on our first experience, we believe that in spite of higher technical difficulty, the aortic valve-sparing operations can be possibly performed with the same or respectively lower rate of postoperative morbidity and mortality. Presented results show that compared with the aortic valve replacement, the aortic valve-sparing operation is a promising method, and an interesting therapeutic alternative for patients. After proper indications, we consider it to be a method of choice (Tab. 6, Fig. 7, Ref. 28).
- Published
- 2014
- Full Text
- View/download PDF
9. One-stage surgical approach to coarctation of the aorta and ascending aortic aneurysm.
- Author
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Sabol F, Mistrikova L, Kolesar A, Luczy J, Toporcer T, and Beres A
- Subjects
- Adult, Aortic Aneurysm complications, Aortic Coarctation complications, Aortic Valve Insufficiency etiology, Female, Humans, Aortic Aneurysm surgery, Aortic Coarctation surgery, Aortic Valve Insufficiency surgery
- Abstract
Background: Aortic coarctation in adults is sometimes associated with concomitant cardiovascular pathologies which require intervention. The optimal operative approach for such patients remains unsettled. An extra-anatomic aortic bypass from the ascending aorta to the descending aorta via median sternotomy allows simultaneous performance of repair of complex aortic coarctation and concomitant cardiac operation., Case Report: We present herein an adult female with coarctation of the aorta combined with an ascending aortic aneurysm associated with concomitant aortic valve regurgitation. We performed a single-stage operation which consisted of Bentall's procedure and extra-anatomic bypass from the ascending to the descending aorta. The patient's postoperative period was uneventful and twelve months after the surgery she is doing well.The conclusions of our work resulted in one essential experience, namely that clinically serious, previously almost intractable conditions can be successfully resolved in unusual ways. Extra-anatomic reconstruction of aorta coarctation that for various reasons could not have been solved by resection of the affected aortic segment allowed us to achieve a structurally as well as functionally excellent outcome. Therefore, we recommend to consider this option in appropriate patients and/or incorporate it into the therapeutic armamentarium of cardiosurgical centers (Fig. 5, Ref. 11).
- Published
- 2014
- Full Text
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10. Use of left ventricle assist device in a pregnant woman with acute aortic and coronary dissections.
- Author
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Kolesar A, Sabol F, Luczy J, and Bajmoczi M
- Subjects
- Acute Disease, Aortic Dissection physiopathology, Aortic Aneurysm physiopathology, Cesarean Section, Coronary Aneurysm physiopathology, Female, Hemodynamics, Humans, Live Birth, Myocardial Infarction physiopathology, Pregnancy, Pregnancy Complications, Cardiovascular physiopathology, Pregnancy Trimester, Third, Shock, Cardiogenic etiology, Treatment Outcome, Aortic Dissection surgery, Aortic Aneurysm surgery, Blood Vessel Prosthesis Implantation adverse effects, Coronary Aneurysm surgery, Coronary Artery Bypass adverse effects, Heart-Assist Devices, Myocardial Infarction surgery, Pregnancy Complications, Cardiovascular surgery, Shock, Cardiogenic therapy
- Abstract
We report the case of a 31-year-old female in her 32nd week of pregnancy, who experienced an acute type A aortic dissection resulting in severe aortic insufficiency, dissection of the left anterior descending coronary artery, and left ventricular infarct with ejection fraction of 20%. After a successful cesarean section, she underwent a Bentall operation and three-vessel coronary artery bypass grafting. Despite maximal inotropic support, her cardiovascular indices deteriorated postoperatively. On the first postoperative day she was started on mechanical circulatory support with the Levitronix CentriMag left ventricular assist device. Her myocardial function improved and she was successfully weaned from this mechanical support on post-implant day 14. She remains alive and well to date.
- Published
- 2010
- Full Text
- View/download PDF
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