1. Timing of antioxidant supplementation is critical in improving anorexia in an experimental model of cancer
- Author
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Gennaro Citro, Maurizio Muscaritoli, Alessandro Laviano, Lucia Fazi, Alessia Mari, Simona De Luca, Alessio Molfino, Filippo Rossi Fanelli, and C. Ramaccini
- Subjects
Male ,medicine.medical_specialty ,Food intake ,Antioxidant ,medicine.medical_treatment ,Interleukin-1beta ,anorexia ,antioxidants ,cancer ,inflammation ,interleukin-1 beta ,oxidative stress ,Inflammation ,Anorexia ,Ascorbic Acid ,Biology ,medicine.disease_cause ,Drug Administration Schedule ,chemistry.chemical_compound ,Random Allocation ,Internal medicine ,medicine ,Animals ,Vitamin E ,Experimental model ,Body Weight ,Cancer ,Sarcoma ,Hydrogen Peroxide ,medicine.disease ,Rats, Inbred F344 ,Diet ,Disease Models, Animal ,Endocrinology ,chemistry ,Methylcholanthrene ,Dietary Supplements ,medicine.symptom ,Energy Intake ,Oxidative stress ,Food Science - Abstract
Increased oxidative stress may contribute to cancer anorexia, which could be ameliorated by antioxidant supplementation. methylcholanthrene (MCA) sarcoma-bearing Fisher rats were studied. After tumour inoculation, rats were randomly assigned to standard diet (CTR group, n = 6), or to an antioxidant-enriched diet (AOX group, n = 8). Eight more rats (STD-AOX group) switched from standard to antioxidant diet when anorexia developed. At the end of the study, food intake (FI, g/d), body weight and tumour weight (g) were recorded, and plasma samples were obtained. On day 16, anorexia has appeared only in CTR and STD-AOX animals. At the end of the study, FI in AOX animals was still higher than in the other groups (p = 0.08). No differences in body and tumour weights were observed among groups. However, hydrogen peroxide and interleukin-1β levels were significantly reduced only in AOX rats. Data obtained suggest that early antioxidant supplementation improves cancer anorexia, ameliorates oxidative stress and reduces inflammation.
- Published
- 2013