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1. A precise measurement of 180 GeV muon energy losses in iron

Author

Amaral, P, Amorim, A, Anderson, K, Artikov, A, Benetta, R, Berglund, S, Biscarat, C, Blanch, O, Blanchot, G, Bogush, A, Bohm, C, Boldea, V, Borisov, O, Bosman, M, Bromberg, C, Bravo, S, Budagov, J, Burdin, S, Caloba, L, Camarena, F, Carvalho, J, Castillo, MV, Cavalli-Sforza, M, Cavasinni, V, Cerqueira, AS, Chadelas, R, Chirikov-Zorin, I, Chlachidze, G, Cobal, M, Cogswell, F, Cologna, S, Constantinescu, S, Costanzo, D, Cowan, B, Crouau, M, Daudon, F, David, M, Davidek, T, Dawson, J, De, K, Delfino, M, Del Prete, T, De Santo, A, Di Girolamo, B, Dita, S, Downing, R, Engström, M, Errede, D, Errede, S, Fassi, F, Fenyuk, A, Ferrer, A, Flaminio, V, Flix, J, Garabik, R, Gil, I, Gildemeister, O, Glagolev, V, Gomes, A, Gonzalez, V, González De La Hoz, S, Grabski, V, Grenier, P, Hakopian, H, Haney, M, Hellman, S, Henriques, A, Hebrard, C, Higon, E, Holik, P, Holmgren, S, Hruska, I, Huston, J, Jon-And, K, Kakurin, S, Karyukhin, A, Khubua, J, Kopikov, S, Krivkova, P, Kukhtin, V, Kulchitsky, Y, Kuzmin, M, Lami, S, Lapin, V, Lazzeroni, C, Lebedev, A, Leitner, R, Li, J, Lomakin, Y, Lomakina, O, Lokajicek, M, Lopez Amengual, JM, Maio, A, Malyukov, S, Marroquin, F, Mataix, L, Mazzoni, E, Merritt, F, Miller, R, and Minashvili, I

Subjects
Nuclear & Particles Physics, Quantum Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

The energy loss spectrum of 180 GeV muons has been measured with the 5.6 m long finely segmented Module 0 of the ATLAS hadron Tile Calorimeter at the CERN SPS. The differential probability dP/dv per radiation length of a fractional energy loss v = ΔΕμ/Εμ has been measured in the range 0.025 ≤ v ≤ 0.97; it is compared with theoretical predictions for energy losses due to bremsstrahlung, production of electron-positron pairs, and energetic knock-on electrons. The iron elastic form factor correction ΔelFe = 1.63 ± 0.17stat ± 0.23Syst±0.200.14theor to muon bremsstrahlung in the region of no screening of the nucleus by atomic electrons has been measured for the first time, and is compared with different theoretical predictions.

Published
2001

2. “Shielding” of Cytokine Induction by the Periodontal Microbiome in Patients with Periodontitis Associated with Type 2 Diabetes Mellitus

Author

Balmasova, I. P., primary, Lomakin, Y. A., additional, Babaev, E. A., additional, Tsarev, V. N., additional, Gabibov, A. G., additional, Smirnov, I. V., additional, Knorre, V. D., additional, Ovchinnikova, L. A., additional, Gnuchev, N. V., additional, Khurs, E. N., additional, Deev, M. S., additional, Kostin, N. N., additional, and Arutyunov, S. D., additional

Published
2019
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4. Divergent immunomodulation capacity of individual myelin peptides-components of liposomal therapeutic against multiple sclerosis

Author

Ivanova V., Khaiboullina S., Gomzikova M., Martynova E., Ferreira A., Garanina E., Sakhapov D., Lomakin Y., Khaibullin T., Granatov E., Khabirov F., Rizvanov A., Gabibov A., and Belogurov A.

Subjects
Multiple sclerosis, Treatment, Myelin basic protein, T helper cells, T regulatory cells, Cytokines/chemokines, Liposomal peptide therapeutic, Dendritic cells
Abstract

© 2017 Ivanova, Khaiboullina, Gomzikova, Martynova, Ferreira, Garanina, Sakhapov, Lomakin, Khaibullin, Granatov, Khabirov, Rizvanov, Gabibov and Belogurov. Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and consequent neuron injury. Although the pathogenesis of MS is largely unknown, a breach in immune self-tolerance to myelin followed by development of autoreactive encephalitogenic T cells is suggested to play the central role. The myelin basic protein (MBP) is believed to be one of the main targets for autoreactive lymphocytes. Recently, immunodominant MBP peptides encapsulated into the mannosylated liposomes, referred as Xemys, were shown to suppress development of experimental autoimmune encephalomyelitis, a rodent model of MS, and furthermore passed the initial stage of clinical trials. Here, we investigated the role of individual polypeptide components [MBP peptides 46-62 (GH17), 124-139 (GK16), and 147-170 (QR24)] of this liposomal peptide therapeutic in cytokine release and activation of immune cells from MS patients and healthy donors. The overall effects were assessed using peripheral blood mononuclear cells (PBMCs), whereas alterations in antigen-presenting capacities were studied utilizing plasmacytoid dendritic cells (pDCs). Among three MBP-immunodominant peptides, QR24 and GK16 activated leukocytes, while GH17 was characterized by an immunosuppressive effect. Peptides QR24 and GK16 upregulated CD4 over CD8 T cells and induced proliferation of CD25 + cells, whereas GH17 decreased the CD4/CD8 T cell ratio and had limited effects on CD25 + T cells. Accordingly, components of liposomal peptide therapeutic differed in upregulation of cytokines upon addition to PBMCs and pDCs. Peptide QR24 was evidently more effective in upregulation of pro-inflammatory cytokines, whereas GH17 significantly increased production of IL-10 through treated cells. Altogether, these data suggest a complexity of action of the liposomal peptide therapeutic that does not seem to involve simple helper T cells (Th)-shift but rather the rebalancing of the immune system.

Published
2017

5. Analysis of Immunogenicity of Intracellular CTAR Fragments of Epstein—Barr Virus Latent Phase Protein LMP1

Author

Lomakin Y., Shmidt A., Bobik T., Chernov A., Pyrkov A., Aleksandrova N., Okunola D., Vaskina M., Ponomarenko N., Telegin G., Dubina M., and Belogurov A.

Subjects
stomatognathic diseases, epitope detection, prokaryotic expression, S12 monoclonal antibody, otorhinolaryngologic diseases, latent membrane protein 1 (LMP1)
Abstract

© 2017, Springer Science+Business Media, LLC. Intracellular fragments of latent phase protein LMP1 of Epstein—Barr virus, denoted as CTAR1/2/3, can trigger a variety of cell cascades and contribute to the transforming potential of the virus. Generation of recombinant proteins CTAR1/2/3 is expected to yield more ample data on functional and immunogenic characteristics of LMP1. We created genetic constructs for prokaryotic expression of LMP1 CTAR fragments and selected optimal conditions for their production and purification. Using a new library of LMP1 CTAR fragments, we carried out epitope mapping of a diagnostic anti-LMP1 antibody S12. Analysis of polyclonal serum antibodies from mice immunized with full-length LMP1 confirmed immunogenicity of CTAR elements comparable with that of full-length protein.

Published
2017

6. Single-Molecule Interactions of a Monoclonal Anti-DNA Antibody with DNA

Author

Nevzorova T., Zhao Q., Lomakin Y., Ponomareva A., Mukhitov A., Purohit P., Weisel J., and Litvinov R.

Subjects
Two-dimensional kinetics, Single-molecule force spectroscopy, DNA, Anti-DNA antibody, Nanomechanics, Optical trap
Abstract

© 2016, Springer Science+Business Media New York.Interactions of DNA with proteins are essential for key biological processes and have both a fundamental and practical significance. In particular, DNA binding to anti-DNA antibodies is a pathogenic mechanism in autoimmune pathology, such as systemic lupus erythematosus. Here we measured at the single-molecule level binding and forced unbinding of surface-attached DNA and a monoclonal anti-DNA antibody MRL4 from a lupus erythematosus mouse. In optical trap-based force spectroscopy, a microscopic antibody-coated latex bead is trapped by a focused laser beam and repeatedly brought into contact with a DNA-coated surface. After careful discrimination of non-specific interactions, we showed that the DNA-antibody rupture force spectra had two regimes, reflecting formation of weaker (20–40 pN) and stronger (>40 pN) immune complexes that implies the existence of at least two bound states with different mechanical stability. The two-dimensional force-free off-rate for the DNA-antibody complexes was ∼2.2 × 10−3 s−1, the transition state distance was ∼0.94 nm, the apparent on-rate was ∼5.26 s−1, and the stiffness of the DNA-antibody complex was characterized by a spring constant of 0.0021 pN/nm, suggesting that the DNA-antibody complex is a relatively stable, but soft and deformable macromolecular structure. The stretching elasticity of the DNA molecules was characteristic of single-stranded DNA, suggesting preferential binding of the MRL4 antibody to one strand of DNA. Collectively, the results provide fundamental characteristics of formation and forced dissociation of DNA-antibody complexes that help to understand principles of DNA-protein interactions and shed light on the molecular basis of autoimmune diseases accompanied by formation of anti-DNA antibodies.

Published
2017

7. Peptides against autoimmune neurodegeneration

Author

Stepanov A., Lomakin Y., Gabibov A., and Belogurov A.

Subjects
Multiple sclerosis, Immunotoxins, Liposomes, Cross-reactivity, Specific allergen immunotherapy, Tolerance, Autoantibodies, Autoreactive B cell elimination
Abstract

© 2017 Bentham Science Publishers. The mammalian immune system is a nearly perfect defensive system polished by a hundred million years of evolution. Unique flexibility and adaptivity have created a virtually impenetrable barrier to numerous exogenous pathogens that are assaulting us every moment. Unfortunately, triggers that remain mostly enigmatic will sometimes persuade the immune system to retarget against self-antigens. This civil war remains underway, showing no mercy and taking no captives, eventually leading to irreversible pathological changes in the human body. Research that has emerged during the last two decades has given us hope that we may have a chance to overcome autoimmune diseases using a variety of techniques to "reset" the immune system. In this report, we summarize recent advances in utilizing short polypeptides - mostly fragments of autoantigens - in the treatment of autoimmune neurodegeneration.

Published
2017

8. Exposure to the Epstein-Barr viral antigen latent membrane protein 1 induces myelin-reactive antibodies in vivo

Author

Lomakin Y., Arapidi G., Chernov A., Ziganshin R., Tcyganov E., Lyadova I., Butenko I., Osetrova M., Ponomarenko N., Telegin G., Govorun V., Gabibov A., and Belogurov A.

Subjects
Multiple sclerosis, Myelin basic protein, Latent membrane protein 1, Cross-reactivity, Epstein-Barr virus, Epitope spreading, Autoantibodies
Abstract

© 2017 Lomakin, Arapidi, Chernov, Ziganshin, Tcyganov, Lyadova, Butenko, Osetrova, Ponomarenko, Telegin, Govorun, Gabibov and Belogurov. Multiple sclerosis (MS) is an autoimmune chronic inflammatory disease of the central nervous system (CNS). Cross-reactivity of neuronal proteins with exogenous antigens is considered one of the possible mechanisms of MS triggering. Previously, we showed that monoclonal myelin basic protein (MBP)-specific antibodies from MS patients cross-react with Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1). In this study, we report that exposure of mice to LMP1 results in induction of myelin-reactive autoantibodies in vivo. We posit that chronic exposure or multiple acute exposures to viral antigen may redirect B cells from production of antiviral antibodies to antibodies, specific to myelin antigen. However, even in inbred animals, which are almost identical in terms of their genomes, such an effect is only observed in 20-50% of animals, indicating that this change occurs by chance, rather than systematically. Cross-immunoprecipitation analysis showed that only part of anti-MBP antibodies from LMP1-immunized mice might simultaneously bind LMP1. In contrast, the majority of anti-LMP1 antibodies from MBP-immunized mice bind MBP. De novo sequencing of anti-LMP1 and anti-MBP antibodies by mass spectrometry demonstrated enhanced clonal diversity in LMP1-immunized mice in comparison with MBP-immunized mice. We suggest that induction of MBP-reactive antibodies in LMP1-immunized mice may be caused by either Follicular dendritic cells (FDCs) or by T cells that are primed by myelin antigens directly in CNS. Our findings help to elucidate the still enigmatic link between EBV infection and MS development, suggesting that myelin-reactive antibodies raised as a response toward EBV protein LMP1 are not truly cross-reactive but are primarily caused by epitope spreading.

Published
2017

10. Polyreactive Monoclonal Autoantibodies in Multiple Sclerosis: Functional Selection from Phage Display Library and Characterization by Deep Sequencing Analysis

Author

Lomakin, Y. A., Zakharova, M. Y., Belogurov, A. A., Bykova, N. A., Dronina, M. A., Tupikin, A. E., Knorre, V. D., Boyko, A. N., Favorov, A. V., Marsel Kabilov, Ponomarenko, N. A., and Gabibov, A. G.

Subjects
Multiple sclerosis, deep sequencing, cross-reactivity, viral triggers, autoreactive B cells, myelin basic protein, Molecular Biology, Research Article
Abstract

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system that primarily affects young and middle-aged people. It is widely accepted that B lymphocyte activation is required for MS progression. Despite the fact that the exact triggering mechanisms of MS remain enigmatic, one may suggest that MS can be induced by viral or bacterial infection in combination with specific genetic and environmental factors. Using deep sequencing and functional selection methodologies we characterized clones of poly- and cross-reactive antibodies that are capable of simultaneous recognition of viral proteins and autoantigens. The latter, in turn, possibly may trigger MS progression through molecular mimicry. It was identified that two cross-reactive antigens are probably recognized by light or heavy chains individually. According to the high structural homology between selected autoantibodies and a number of various antiviral IgGs, we suggest that a wide range of pathogens, instead of a single virus, be regarded as possible triggers of MS.

Published
2013

11. Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF- α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients

Author

Lomakin Y., Belogurov A., Glagoleva I., Stepanov A., Zakharov K., Okunola J., Smirnov I., Genkin D., and Gabibov A.

Abstract

© 2016 Yakov Lomakin et al.We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys administration in MS patients. We observed a statistically significant decrease of MCP-1/CCL2, MIP-1β/CCL4, IL-7, and IL-2 at the time of study completion. In contrast, the serum levels of TNF-α were remarkably elevated. Our data suggest that the administration of Xemys leads to a normalization of cytokine status in MS patients to values commonly reported for healthy subjects. These data are an important contribution for the upcoming Xemys clinical trials.

Published
2016

12. CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Author

Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., and Evdoshenko E.

Subjects
Clinical trial, Myelin basic protein, Xemys, Liposomes, Mannose, MRI
Abstract

© 2016, The Author(s).Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental autoimmune encephalomyelitis in dark Agouti rats. The objective of this study was to assess the safety of Xemys in the treatment of patients with relapsing-remitting multiple sclerosis (MS) and secondary progressive MS, who failed to achieve a sustained response to first-line disease-modifying therapies. In this phase I, open-label, dose-escalating, proof-of-concept study, 20 patients with relapsing-remitting or secondary progressive MS received weekly subcutaneously injections with ascending doses of Xemys up to a total dose of 2.675 mg. Clinical examinations, including Expanded Disability Status Scale score, magnetic resonance imaging results, and serum cytokine concentrations, were assessed before the first injection and for up to 17 weeks after the final injection. Xemys was safe and well tolerated when administered for 6 weeks to a maximum single dose of 900 μg. Expanded Disability Status Scale scores and numbers of T2-weighted and new gadolinium-enhancing lesions on magnetic resonance imaging were statistically unchanged at study exit compared with baseline; nonetheless, the increase of number of active gadolinium-enhancing lesions on weeks 7 and 10 in comparison with baseline was statistically significant. During treatment, the serum concentrations of the cytokines monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and interleukin-7 decreased, whereas the level of tumor necrosis factor-α increased. These results provide evidence for the further development of Xemys as an antigen-specific, disease-modifying therapy for patients with MS.

Published
2016

13. Myelin-Reactive Monoclonal Antibodies from Multiple Sclerosis Patients Cross-React with Nucleoproteins in HEp-2 Lysate

Author

Lomakin Y., Shmidt A., Glagoleva I., Okunola J., Vaskina M., Belogurov A., and Gabibov A.

Subjects
Myelin basic protein, IgG, Cross-reactivity, Autoimmunity, MS, Polyreactivity
Abstract

© 2016, Springer Science+Business Media New York.Autoimmune disorders are characterized by appearance of self-reactive species of immune system such as T cells, B cells and antibodies. For the majority of autoimmune pathologies the list of specific autoantigens is known. Myelin basic protein (MBP) is one of the most important autoantigens in multiple sclerosis (MS), which destruction is a hallmark of disease progression. Antibodies toward MBP are found in serum and cerebrospinal fluid of MS patients. Here we investigated whether monoclonal human MBP-specific antibodies selected from MS patients repertoire cross-react with other autoimmune markers. For this purpose we performed Western blot analysis of recombinant anti-MBP antibodies with HEp-2 cell lysate. Our data suggest existence of enhanced level of cross-reactivity of anti-MBP antibodies with ribonucleoprotein A (RNP A), a marker of Sharp’s syndrome and systemic lupus erythematosus, ribosomal P protein (Rib. P-Prot), a marker for systemic lupus erythematosus, and centromere protein A/B (CENP A/B), markers for progressive systemic sclerosis.

Published
2016

14. Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity

Author

Belogurov A., Kuzina E., Kudriaeva A., Kononikhin A., Kovalchuk S., Surina Y., Smirnov I., Lomakin Y., Bacheva A., Stepanov A., Karpova Y., Lyupina Y., Kharybin O., Melamed D., Ponomarenko N., Sharova N., Nikolaev E., and Gabibov A.

Subjects
Multiple sclerosis, Experimental autoimmune encephalomyelitis, Oligodendrocytes, Antigen presentation, Immunoproteasome
Abstract

© The Author(s). Recent findings indicate that the ubiquitin-proteasome system is involved in the pathogenesis of cancer as well as autoimmune and several neurodegenerative diseases, and is thus a target for novel therapeutics. One disease that is related to aberrant protein degradation is multiple sclerosis, an autoimmune disorder involving the processing and presentation of myelin autoantigens that leads to the destruction of axons. Here, we show that brainderived proteasomes from SJL mice with experimental autoimmune encephalomyelitis (EAE) in an ubiquitinindependent manner generate significantly increased amounts of myelin basic protein peptides that induces cytotoxic lymphocytes to target mature oligodendrocytes ex vivo. Ten times enhanced release of immunogenic peptides by cerebral proteasomes from EAE-SJL mice is caused by a dramatic shift in the balance between constitutive and β1ihigh immunoproteasomes in the CNS of SJL mice with EAE. We found that during EAE, β1i is increased in resident CNS cells, whereas β5i is imported by infiltrating lymphocytes through the blood-brain barrier. Peptidyl epoxyketone specifically inhibits brain-derived β1ihigh immunoproteasomes in vitro (kobs/[I] = 240 M-1s-1), and at a dose of 0.5 mg/kg, it ameliorates ongoing EAE in vivo. Therefore, our findings provide novel insights into myelin metabolism in pathophysiologic conditions and reveal that the β1i subunit of the immunoproteasome is a potential target to treat autoimmune neurologic diseases.

Published
2015

15. The optical instrumentation of the ATLAS Tile Calorimeter

Author

Abdallah, J. Adragna, P. Alexa, C. Alves, R. Amaral, P. and Ananiev, A. Anderson, K. Andresen, X. Antonaki, A. and Batusov, V. Bednar, P. Bergeaas, E. Biscarat, C. Blanch, O. Blanchot, G. Bohm, C. Boldea, V. Bosi, F. Bosman, M. Bromberg, C. Budagov, J. Calvet, D. Cardeira, C. and Carli, T. Carvalho, J. Cascella, M. Castillo, M. V. and Costelo, J. Cavalli-Sforza, M. Cavasinni, V. Cerqueira, A. S. Clement, C. Cobal, M. Cogswell, F. Constantinescu, S. and Costanzo, D. Da Silva, P. David, M. Davidek, T. and Dawson, J. De, K. Del Prete, T. Diakov, E. Di Girolamo, B. Dita, S. Dolejsi, J. Dolezal, Z. Dotti, A. and Downing, R. Drake, G. Efthymiopoulos, I. Errede, D. and Errede, S. Farbin, A. Fassouliotis, D. Feng, E. Fenyuk, A. Ferdi, C. Ferreira, B. C. Ferrer, A. Flaminio, V. and Flix, J. Francavilla, P. Fullana, E. Garde, V. and Gellerstedt, K. Giakoumopoulou, V. Giangiobbe, V. and Gildemeister, O. Gilewsky, V. Giokaris, N. Gollub, N. and Gomes, A. Gonzalez, V. Gouveia, J. Grenier, P. Gris, P. and Guarino, V. Guicheney, C. Gupta, A. Hakobyan, H. and Haney, M. Hellman, S. Henriques, A. Higon, E. Hill, N. and Holmgren, S. Hruska, I. Hurwitz, M. Huston, J. and Plante, I. Jen-La Jon-And, K. Junk, T. Karyukhin, A. and Khubua, J. Klereborn, J. Konstantinov, V. Kopikov, S. and Korolkov, I. Krivkova, P. Kulchitsky, Y. Kurochkin, Yu and Kuzhir, P. Lapin, V. LeCompte, T. Lefevre, R. Leitner, R. Li, J. Liablin, M. Lokajicek, M. Lomakin, Y. and Lourtie, P. Lovas, L. Lupi, A. Maidantchik, C. Maio, A. and Maliukov, S. Manousakis, A. Marques, C. Marroquim, F. and Martin, F. Mazzoni, E. Merritt, F. Miagkov, A. and Miller, R. Minashvili, I. Miralles, L. Montarou, G. and Nemecek, S. Nessi, M. Nikitine, I. Nodulman, L. and Norniella, O. Onofre, A. Oreglia, M. Palan, B. Pallin, D. Pantea, D. Pereira, A. Pilcher, J. Pina, J. and Pinhao, J. Pod, E. Podlyski, F. Portell, X. Poveda, J. and Pribyl, L. Price, E. Proudfoot, J. Ramalho, M. and Ramstedt, M. Raposeiro, L. Reis, J. Richards, R. Roda, C. Romanov, V. Rosnet, P. Roy, P. Ruiz, A. and Rumiantsau, V. Russakovich, N. Da Costa, J. Sa Salto, O. and Salvachua, B. Sanchis, E. Sanders, H. Santoni, C. and Santos, J. Saraiva, J. G. Sarri, F. Says, L. -P. and Schlager, G. Schlereth, J. Seixas, J. M. Sellden, B. and Shalanda, N. Shevtsov, P. Shochet, M. Silva, J. and Simaitis, V. Simonyan, M. Sissakian, A. Sjoelin, J. and Solans, C. Solodkov, A. Solovianov, O. Sosebee, M. and Spano, F. Speckmeyer, P. Stanek, R. Starchenko, E. and Starovoitov, P. Suk, M. Sykora, I. Tang, F. Tas, P. and Teuscher, R. Tischenko, M. Tokar, S. Topilin, N. Torres, J. Underwood, D. Usai, G. Valero, A. Valkar, S. and Valls, J. A. Vartapetian, A. Vazeille, F. Vellidis, C. and Ventura, F. Vichou, I. Vivarelli, I. Volpi, M. White, A. and Zaitsev, A. Zaytsev, Yu Zenin, A. Zenis, T. Zenonos, Z. Zenz, S. Zilka, B. ATLAS Tile Calorimeter Community

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Experiment
Abstract

The Tile Calorimeter, covering the central region of the ATLAS experiment up to pseudorapidities of +/-1.7, is a sampling device built with scintillating tiles that alternate with iron plates. The light is collected in wave-length shifting (WLS) fibers and is read out with photomultipliers. In the characteristic geometry of this calorimeter the tiles lie in planes perpendicular to the beams, resulting in a very simple and modular mechanical and optical layout. This paper focuses on the procedures applied in the optical instrumentation of the calorimeter, which involved the assembly of about 460,000 scintillator tiles and 550,000 WLS fibers. The outcome is a hadronic calorimeter that meets the ATLAS performance requirements, as shown in this paper.

Published
2013

16. Mechanical construction and installation of the ATLAS tile calorimeter

Author

Abdallah, J. Adragna, P. Alexa, C. Alves, R. Amaral, P. Ananiev, A. Anderson, K. Andresen, X. Antonaki, A. Batusov, V. Bednar, P. Behrens, A. Bergeaas, E. Biscarat, C. Blanch, O. Blanchot, G. Blocki, J. Bohm, C. Boldea, V. Bosi, F. Bosman, M. Bromberg, C. Brunel, B. Budagov, J. Calderón, D. Calvet, D. Cardeira, C. Carli, T. Carvalho, J. Cascella, M. Castillo, M.V. Costello, J. Cavalli-Sforza, M. Cavasinni, V. Cerqueira, A.S. Clement, C. Cobal, M. Cogswell, F. Constantinescu, S. Costanzo, D. Da Silva, P. David, M. Davidek, T. Dawson, J. De, K. Del Prete, T. Di Girolamo, B. Dita, S. Dolejsi, J. Dolezal, Z. Dotti, A. Downing, R. Drake, G. Efthymiopoulos, I. Errede, D. Errede, S. Farbin, A. Fassouliotis, D. Feng, E. Fenyuk, A. Ferdi, C. Ferreira, B.C. Ferrer, A. Ferrer, J. Flaminio, V. Flix, J. Francavilla, P. Fullana, E. Garde, V. Gayde, J.C. Gellerstedt, K. Giakoumopoulou, V. Giangiobbe, V. Gildemeister, O. Gilewsky, V. Giokaris, N. Gollub, N. Gomes, A. Gonzalez, V. Gouveia, J. Grenier, P. Gris, P. Grudzinski, J. Guarino, V. Guicheney, C. Gupta, A. Hakobyan, H. Haney, M. Hellman, S. Henriques, A. Higon, E. Hill, N. Holmgren, S. Hruska, I. Hurwitz, M. Huston, J. Jen-La Plante, I. Jon-And, K. Junk, T. Karyukhin, A. Khubua, J. Klereborn, J. Kopikov, S. Korolkov, I. Krivkova, P. Kulchitsky, Y. Kurochkin, Y. Kuzhir, P. Lapin, V. Lasseur, C. Lecompte, T. Lefevre, R. Leitner, R. Li, J. Lyablin, M. Lim, H. Lokajicek, M. Lomakin, Y. Lourtie, P. Lovas, L. Lupi, A. Maidantchik, C. Maio, A. Maliukov, S. Manousakis, A. Marques, C. Marroquim, F. Martin, F. Mazzoni, E. Mergelkuhl, D. Merritt, F. Miagkov, A. Miller, R. Minashvili, I. Miralles, L. Montarou, G. Nemecek, S. Nessi, M. Nikitine, I. Nodulman, L. Norniella, O. Nyman, T. Onofre, A. Oreglia, M. Palan, B. Pallin, D. Pantea, D. Pereira, A. Pilcher, J. Pina, J. Pinhão, J. Pod, E. Podlyski, F. Portell, X. Poveda, J. Pribyl, L. Price, L.E. Proudfoot, J. Ramalho, M. Ramstedt, M. Raposeiro, L. Reis, J. Richards, R. Roda, C. Romanov, V. Rose-Dulcina, L. Rosnet, P. Roy, P. Ruiz, A. Rumiantsau, V. Russakovich, N. Sa Da Costa, J. Salto, O. Salvachua, B. Sanchis, E. Sanders, H. Santoni, C. Santos, J. Saraiva, J.G. Sarri, F. -P Says, L. Schlager, G. Schlereth, J. Seixas, J.M. Selldèn, B. Shalanda, N. Shchelchkov, A. Shevtsov, P. Shochet, M. Silva, J. Simaitis, V. Simonyan, M. Sissakian, A. Sjoelin, J. Skrzecz, F. Solans, C. Solodkov, A. Solovianov, O. Sorokina, J. Sosebee, M. Spano, F. Speckmeyer, P. Stanek, R. Starchenko, E. Starovoitov, P. Suk, M. Sykora, I. Tang, F. Tas, P. Teuscher, R. Tokar, S. Topilin, N. Torres, J. Underwood, D. Usai, G. Utkin, V. Valero, A. Valkar, S. Valls, J.A. Vartapetian, A. Vazeille, F. Vellidis, C. Ventura, F. Vichou, I. Vivarelli, I. Volpi, M. White, A. Wood, K. Zaitsev, A. Zenin, A. Zenis, T. Zenonos, Z. Zenz, S. Zilka, B.

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Experiment
Abstract

This paper summarises the mechanical construction and installation of the Tile Calorimeter for the ATLAS experiment at the Large Hadron Collider in CERN, Switzerland. The Tile Calorimeter is a sampling calorimeter using scintillator as the sensitive detector and steel as the absorber and covers the central region of the ATLAS experiment up to pseudorapidities ±1.7. The mechanical construction of the Tile Calorimeter occurred over a period of about 10 years beginning in 1995 with the completion of the Technical Design Report and ending in 2006 with the installation of the final module in the ATLAS cavern. During this period approximately 2600 metric tons of steel were transformed into a laminated structure to form the absorber of the sampling calorimeter. Following instrumentation and testing, which is described elsewhere, the modules were installed in the ATLAS cavern with a remarkable accuracy for a structure of this size and weight. © CERN 2013 for the benefit of the ATLAS collaboration.

Published
2013

17. Testbeam studies of production modules of the ATLAS Tile Calorimeter

Author

Adragna, P. Alexa, C. Anderson, K. Antonaki, A. Arabidze, A. Batkova, L. Batusov, V. Beck, H.P. Bednar, P. Bergeaas Kuutmann, E. Biscarat, C. Blanchot, G. Bogush, A. Bohm, C. Boldea, V. Bosman, M. Bromberg, C. Budagov, J. Burckhart-Chromek, D. Caprini, M. Caloba, L. Calvet, D. Carli, T. Carvalho, J. Cascella, M. Castelo, J. Castillo, M.V. Cavalli-Sforza, M. Cavasinni, V. Cerqueira, A.S. Clement, C. Cobal, M. Cogswell, F. Constantinescu, S. Costanzo, D. Corso-Radu, A. Cuenca, C. Damazio, D.O. David, M. Davidek, T. De, K. Del Prete, T. Di Girolamo, B. Dita, S. Djobava, T. Dobson, M. Dolejsi, J. Dolezal, Z. Dotti, A. Downing, R. Efthymiopoulos, I. Eriksson, D. Errede, D. Errede, S. Farbin, A. Fassouliotis, D. Febbraro, R. Fedorko, I. Fenyuk, A. Ferdi, C. Ferrer, A. Flaminio, V. Francis, D. Fullana, E. Gadomski, S. Gameiro, S. Garde, V. Gellerstedt, K. Giakoumopoulou, V. Gildemeister, O. Gilewsky, V. Giokaris, N. Gollub, N. Gomes, A. Gonzalez, V. Gorini, B. Grenier, P. Gris, P. Gruwe, M. Guarino, V. Guicheney, C. Gupta, A. Haeberli, C. Hakobyan, H. Haney, M. Hellman, S. Henriques, A. Higon, E. Holmgren, S. Hurwitz, M. Huston, J. Iglesias, C. Isaev, A. Jen-La Plante, I. Jon-And, K. Joos, M. Junk, T. Karyukhin, A. Kazarov, A. Khandanyan, H. Khramov, J. Khubua, J. Kolos, S. Korolkov, I. Krivkova, P. Kulchitsky, Y. Kurochkin, Yu. Kuzhir, P. Le Compte, T. Lefevre, R. Lehmann, G. Leitner, R. Lembesi, M. Lesser, J. Li, J. Liablin, M. Lokajicek, M. Lomakin, Y. Lupi, A. Maidanchik, C. Maio, A. Makouski, M. Maliukov, S. Manousakis, A. Mapelli, L. Marques, C. Marroquim, F. Martin, F. Mazzoni, E. Merritt, F. Miagkov, A. Miller, R. Minashvili, I. Miralles, L. Montarou, G. Mosidze, M. Myagkov, A. Nemecek, S. Nessi, M. Nodulman, L. Nordkvist, B. Norniella, O. Onofre, A. Oreglia, M. Pallin, D. Pantea, D. Petersen, J. Pilcher, J. Pina, J. Pinhão, J. Podlyski, F. Portell, X. Poveda, J. Pribyl, L. Price, L.E. Proudfoot, J. Ramstedt, M. Richards, R. Roda, C. Romanov, V. Rosnet, P. Roy, P. Ruiz, A. Rumiantsev, V. Russakovich, N. Saltó, O. Salvachua, B. Sanchis, E. Sanders, H. Santoni, C. Santos, J. Saraiva, J.G. Sarri, F. Satsunkevitch, I. Says, L.-P. Schlager, G. Schlereth, J. Seixas, J.M. Selldèn, B. Shalanda, N. Shevtsov, P. Shochet, M. Silva, J. Da Silva, P. Simaitis, V. Simonyan, M. Sissakian, A. Sjölin, J. Solans, C. Solodkov, A. Soloviev, I. Solovyanov, O. Sosebee, M. Spanò, F. Stanek, R. Starchenko, E. Starovoitov, P. Stavina, P. Suk, M. Sykora, I. Tang, F. Tas, P. Teuscher, R. Tokar, S. Topilin, N. Torres, J. Tremblet, L. Tsiareshka, P. Tylmad, M. Underwood, D. Unel, G. Usai, G. Valero, A. Valkar, S. Valls, J.A. Vartapetian, A. Vazeille, F. Vichou, I. Vinogradov, V. Vivarelli, I. Volpi, M. White, A. Zaitsev, A. Zenine, A. Zenis, T.

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Experiment
Abstract

We report test beam studies of 11% of the production ATLAS Tile Calorimeter modules. The modules were equipped with production front-end electronics and all the calibration systems planned for the final detector. The studies used muon, electron and hadron beams ranging in energy from 3 to 350 GeV. Two independent studies showed that the light yield of the calorimeter was ∼ 70 pe / GeV, exceeding the design goal by 40%. Electron beams provided a calibration of the modules at the electromagnetic energy scale. Over 200 calorimeter cells the variation of the response was 2.4%. The linearity with energy was also measured. Muon beams provided an intercalibration of the response of all calorimeter cells. The response to muons entering in the ATLAS projective geometry showed an RMS variation of 2.5% for 91 measurements over a range of rapidities and modules. The mean response to hadrons of fixed energy had an RMS variation of 1.4% for the modules and projective angles studied. The response to hadrons normalized to incident beam energy showed an 8% increase between 10 and 350 GeV, fully consistent with expectations for a noncompensating calorimeter. The measured energy resolution for hadrons of σ / E = 52.9 % / sqrt(E) ⊕ 5.7 % was also consistent with expectations. Other auxiliary studies were made of saturation recovery of the readout system, the time resolution of the calorimeter and the performance of the trigger signals from the calorimeter. © 2009 Elsevier B.V. All rights reserved.

Published
2009

18. The Production and Qualification of Scintillator Tiles for the ATLAS Hadronic Calorimeter

Author

Abdallah, J, Adragna, P, Alexa, C, Alves, R, Amaral, P, Ananiev, A, Anderson, K, Andresen, X, Antonaki, A, Batusov, V, Bednar, P, Bergeaas, E, Biscarat, C, Blanch, O, Blanchot, G, Bohm, C, Boldea, V, Bosi, F, Bosman, M, Bromberg, C, Budagov, Yu, Calvet, D, Cardeira, C, Carli, T, Carvalho, J, Cascella, M, Castillo, M V, Costello, J, Cavalli-Sforza, M, Cavasinni, V, Cerqueira, A S, Clément, C, Cobal, M, Cogswell, F, Constantinescu, S, Costanzo, D, Da Silva, P, David, M, Davidek, T, Dawson, J, De, K, Del Prete, T, Diakov, E, Di Girolamo, B, Dita, S, Dolejsi, J, Dolezal, Z, Dotti, A, Downing, R, Drake, G, Efthymiopoulos, I, Errede, D, Errede, S, Farbin, A, Fassouliotis, D, Feng, E, Fenyuk, A, Ferdi, C, Ferreira, B C, Ferrer, A, Flaminio, V, Flix, J, Francavilla, P, Fullana, E, Garde, V, Gellerstedt, K, Giakoumopoulou, V, Giangiobbe, V, Gildemeister, O, Gilewsky, V, Giokaris, N, Gollub, N, Gomes, A, González, V, Gouveia, J, Grenier, P, Gris, P, Guarino, V, Guicheney, C, Sen-Gupta, A, Hakobyan, H, Haney, M, Hellman, S, Henriques, A, Higón, E, Hill, N, Holmgren, S, Hruska, I, Hurwitz, M, Huston, J, Jen-La Plante, I, Jon-And, K, Junk, T, Karyukhin, A, Khubua, J, Klereborn, J, Konsnantinov, V, Kopikov, S, Korolkov, I, Krivkova, P, Kulchitskii, Yu A, Kurochkin, Yu, Kuzhir, P, Lapin, V, LeCompte, T, Lefèvre, R, Leitner, R, Li, J, Liablin, M, Lokajícek, M, Lomakin, Y, Lourtie, P, Lovas, L, Lupi, A, Maidantchik, C, Maio, A, Maliukov, S, Manousakis, A, Marques, C, Marroquim, F, Martin, F, Mazzoni, E, Merritt, F S, Myagkov, A, Miller, R, Minashvili, I, Miralles, L, Montarou, G, Némécek, S, Nessi, M, Nikitine, I, Nodulman, L, Norniella, O, Onofre, A, Oreglia, M, Palan, B, Pallin, D, Pantea, D, Pereira, A, Pilcher, J E, Pina, J, Pinhão, J, Pod, E, Podlyski, F, Portell, X, Poveda, J, Pribyl, a L, Price, L E, Proudfoot, J, Ramalho, M, Ramstedt, M, Raposeiro, L, Reis, J, Richards, R, Roda, C, Romanov, V, Rosnet, P, Roy, P, Ruiz, A, Rumiantsau, V, Rusakovich, N, Sada Costa, J, Salto, O, Salvachúa, B, Sanchis, E, Sanders, H, Santoni, C, Santos, J, Saraiva, J G, Sarri, F, Says, L P, Schlager, G, Schlereth, J L, Seixas, J M, Selldén, B, Shalanda, N, Shevtsov, P, Shochet, M, Silva, J, Simaitis, V, Simonyan, M, Sisakian, A, Sjölin, J, Solans, C, Solodkov, A, Solovyanov, O, Sosebee, M, Spanó, F, Speckmeyer, P, Stanek, R, Starchenko, E, Starovoitov, P, Suk, M, Sykora, I, Tang, F, Tas, P, Teuscher, R, Tischenko, M, Tokar, S, Topilin, N, Torres, J, Underwood, D, Usai, G, Valero, A, Valkár, S, Valls, J A, Vartapetian, A, Vazeille, F, Vellidis, C, Ventura, F, Vichou, I, Vivarelli, I, Volpi, M, White, A, Zaitsev, A, Zaytsev, Yu, Zenin, A, Zenis, T, Zenonos, Z, Zenz, S, and Zilka, B

Subjects
Physics::Instrumentation and Detectors, Detectors and Experimental Techniques
Abstract

The production of the scintillator tiles for the ATLAS Tile Calorimeter is presented. In addition to the manufacture and production, the properties of the tiles will be presented including light yield, uniformity and stability.

Published
2007

19. The ATLAS hadronic Tile Calorimeter: From construction toward physics

Author

Adragna, P. Cavasinni, V. Costanzo, D. del Prete, T. Dotti, A. Flaminio, V. Lupi, A. Mazzoni, E. Roda, C. Sarri, F. Usai, G. Vivarelli, I. Alexa, C. Boldea, V. Constantinescu, S. Dita, S. Pantea, D. Anderson, K. Farbin, A. Gupta, A. Hurwitz, M. Merritt, F. Oreglia, M. Pilcher, J. Sanders, H. Shochet, M. Tang, F. Teuscher, R. Antonaki, A. Fassouliotis, D. Giakoumopoulou, V. Giokaris, N. Lembesi, M. Manousakis, A. Batusov, V. Budagov, J. Liablin, M. Lomakin, Y. Maliukov, S. Minashvili, I. Romanov, V. Russakovich, N. Sissakian, A. Topilin, N. Vinogradov, V. Bednar, P. Fedorko, I. Sykora, I. Tokar, S. Zenis, T. Biscarat, C. Calvet, D. Ferdi, C. Garde, V. Gris, P. Guicheney, C. Lefevre, R. Montarou, G. Pallin, D. Podlyski, F. Rosnet, P. Roy, P. Santoni, C. Says, L.-P. Vazeille, F. Blanchot, G. Bosman, M. Cavalli-Sforza, M. Korolkov, I. Miralles, L. Norniella, O. Portell, X. Saltó, O. Volpi, M. Bogush, A. Gilewsky, V. Kurochkin, Y. Satsunkevitch, I. Bohm, C. Holmgren, S. Jon-And, K. Klereborn, J. Ramstedt, M. Selldèn, B. Bromberg, C. Huston, J. Miller, R. Richards, R. Caloba, L. Cerqueira, A.S. Damazio, D.O. Maidantchik, C. Marroquim, F. Seixas, J.M. da Silva, P. Carvalho, J. Pinhão, J. Castelo, J. Castillo, M.V. Cuenca, C. Ferrer, A. Fullana, E. Gonzalez, V. Higon, E. Iglesias, C. Lopez Amengual, J.M. Poveda, J. Salvachua, B. Sanchis, E. Torres, J. Valls, J.A. Cobal, M. di Girolamo, B. Efthymiopoulos, I. Gildemeister, O. Grenier, P. Henriques, A. Martin, F. Nessi, M. Schlager, G. Spanó, F. Cogswell, F. Downing, R. Errede, D. Errede, S. Haney, M. Junk, T. Simaitis, V. Vichou, I. David, M. Gomes, A. Maio, A. Marques, C. Pina, J. Saraiva, J.G. Silva, J. Santos, J. Davidek, T. Dolejsi, J. Dolezal, Z. Krivkova, P. Leitner, R. Suk, M. Tas, P. Valkar, S. De, K. Li, J. Sosebee, M. Vartapetian, A. White, A. Fenyuk, A. Karyukhin, A. Miagkov, A. Solodkov, A. Solovianov, O. Starchenko, E. Zaitsev, A. Zenine, A. Guarino, V. le Compte, T. Nodulman, L. Price, L.E. Proudfoot, J. Schlereth, J. Stanek, R. Underwood, D. Hakobyan, H. Simonyan, M. Khubua, J. Kulchitsky, Y. Kuzhir, P. Rumiantsau, V. Shevtsov, P. Starovoitov, P. Lokajicek, M. Nemecek, S. Pribyl, L. Onofre, A.

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Experiment
Abstract

The Tile Calorimeter, which constitutes the central section of the ATLAS hadronic calorimeter, is a non-compensating sampling device made of iron and scintillating tiles. The construction phase of the calorimeter is nearly complete, and most of the effort now is directed toward the final assembly and commissioning in the underground experimental hall. The layout of the calorimeter and the tasks carried out during construction are described, first with a brief reminder of the requirements that drove the calorimeter design. During the last few years a comprehensive test-beam program has been followed in order to establish the calorimeter electromagnetic energy scale, to study its uniformity, and to compare real data to Monte Carlo simulation. The test-beam setup and first results from the data are described. During the test-beam period in 2004, lasting several months, data have been acquired with a complete slice of the central ATLAS calorimeter. The data collected in the test-beam are crucial in order to study algorithms for hadronic energy reconstruction using single particles. The generalization of these algorithms to reconstruct jet energies will be the starting point for numerous physics studies in which jets play a leading role. The results obtained in applying these algorithms to simulated di-jet events are given in the last section of the note. © 2006 IEEE.

Published
2006

20. A measurement of the photonuclear interactions of 180 GeV muons in iron: The tilecal system of the ATLAS collaboration

Author

Alexa, C. Anderson, K. Antonaki, A. Batusov, V. Berglund, S. Biscarat, C. Blanch, O. Blanchot, G. Bogush, A. Bohm, C. Boldea, V. Bosman, M. Bromberg, C. Budagov, J. Caloba, L. Calvet, D. Camarena, F. Carvalho, J. Castelo, J. Castillo, M.V. Cavalli-Sforza, M. Cavasinni, V. Cerqueira, A.S. Cobal, M. Cogswell, F. Constantinescu, S. Costanzo, D. Cowan, B. Cuenca, C. Damazio, D.O. David, M. Davidek, T. De, K. Delfino, M. Del Prete, T. Di Girolamo, B. Dita, S. Dolejsi, J. Dolezal, Z. Dotti, A. Downing, R. Efthymiopoulos, I. Engström, M. Errede, D. Errede, S. Fassi, F. Fassouliotis, D. Fedorko, I. Fenyuk, A. Ferdi, C. Ferrer, A. Flaminio, V. Flix, J. Fullana, E. Garabik, R. Garde, V. Giakoumopoulou, V. Gildemeister, O. Gilewsky, V. Giokaris, N. Gomes, A. Gonzalez, V. de la Hoz, S.G. Grabsky, V. Grenier, P. Gris, P. Guarino, V. Guicheney, C. Gupta, A. Hakobyan, H. Haney, M. Henriques, A. Higon, E. Holmgren, S. Huston, J. Iglesias, C. Jon-And, K. Junk, T. Karyukhin, A. Khubua, J. Kopikov, S. Korolkov, I. Krivkova, P. Kulchitsky, Y. Kuzhir, P. Lapin, V. Le Compte, T. Lefevre, R. Leitner, R. Lembesi, M. Li, J. Liablin, M. Lomakin, Y. Lokajicek, M. Lopez Amengual, J.M. Maio, A. Maliukov, S. Manousakis, A. Marques, C. Marroquim, F. Martin, F. Mazzoni, E. Merritt, F. Miller, R. Minashvili, I. Miralles, L. Montarou, G. Nemecek, S. Nessi, M. Nodulman, L. Norniella, O. Onofre, A. Oreglia, M. Pacheco, A. Pallin, D. Pantea, D. Pilcher, J. Pina, J. Pinhão, J. Podlyski, F. Portell, X. Price, L.E. Proudfoot, J. Richards, R. Roda, C. Romanov, V. Rosnet, P. Roy, P. Rumiantsau, V. Russakovich, N. Salvachua, B. Sanchis, E. Sanders, H. Santoni, C. Saraiva, J.G. Satsunkevitch, I. Says, L.-P. Schlereth, J. Seixas, J.M. Selldèn, B. Shalanda, N. Shevtsov, P. Shochet, M. Silva, J. Simaitis, V. Sissakian, A. Sjölin, J. Soares, S. Solodkov, A. Solovianov, O. Sosebee, M. Stanek, R. Starchenko, E. Starovoitov, P. Stavina, P. Suk, M. Sykora, I. Tang, F. Tas, P. Teuscher, R. Tokar, S. Topilin, N. Torres, J. Tsulaia, V. Underwood, D. Usai, G. Valkar, S. Varanda, M.J. Vartapetian, A. Vazeille, F. Vichou, I. Vinogradov, V. Vivarelli, I. White, A. Zaitsev, A. Zenis, T.

Abstract

The energy spectrum and the cross section of photonuclear interactions of 180 GeV muons in iron were measured at the CERN SPS using prototype modules of the ATLAS hadron calorimeter. The differential cross section (NA/A)vdσ/dv for a muon fractional energy loss v = ΔEμ/Eμ was measured in the range 0.1

Published
2003

21. A measurement of the photonuclear interactions of 180 GeV muons in iron

Author

Alexa, C, Anderson, K, Antonaki, A, Batusov, V, Berglund, S, Biscarat, C, Blanch, O, Blanchot, G, Bogush, A, Bohm, C, Boldea, V, Bosman, M, Bromberg, C, Budagov, J, Caloba, L, Calvet, D, Camarena, F, Carvalho, J, Castelo, J, Castillo, Mv, Cavalli Sforza, M, Cavasinni, Vincenzo, Cerqueira, As, Cobal, M, Cogswell, F, Constantinescu, S, Costanzo, D, Cowan, B, Cuenca, C, Damazio, Do, David, M, Davidek, T, De, K, Delfino, M, Del Prete, T, Di Girolamo, B, Dita, S, Dolejsi, J, Dolezal, Z, Dotti, A, Downing, R, Efthymiopoulos, I, Engstrom, M, Errede, D, Errede, S, Fassi, F, Fassouliotis, D, Fedorko, I, Fenyuk, A, Ferdi, C, Ferrer, A, Flaminio, V, Flix, J, Fullana, E, Garabik, R, Garde, V, Giakoumopoulou, V, Gildemeister, O, Gilewsky, V, Giokaris, N, Gomes, A, Gonzalez, V, De La Hoz SG, Grabsky, V, Grenier, P, Gris, P, Guarino, V, Guicheney, C, Gupta, A, Hakobyan, H, Haney, M, Henriques, A, Higon, E, Holmgren, S, Huston, J, Iglesias, C, Jon And, K, Junk, T, Karyukhin, A, Khubua, J, Kopikov, S, Korolkov, I, Krivkova, P, Kulchitsky, Y, Kuzhir, P, Lapin, V, Le Compte, T, Lefevre, R, Leitner, R, Lembesi, M, Li, J, Liablin, M, Lomakin, Y, Lokajicek, M, Amengual, Jml, Maio, A, Maliukov, S, Manousakis, A, Marques, C, Marroquim, F, Martin, F, Mazzoni, E, Merritt, F, Miller, R, Minashvili, I, Miralles, L, Montarou, G, Nemecek, S, Nessi, M, Nodulman, L, Norniella, O, Onofre, A, Oreglia, M, Pacheco, A, Pallin, D, Pantea, D, Pilcher, J, Pina, J, Pinh ao, J, Podlyski, F, Portell, X, Price, Le, Proudfoot, J, Richards, R, Roda, CHIARA MARIA ANGELA, Romanov, V, Rosnet, P, Roy, P, Rumiantsau, V, Russakovich, N, Salvachua, B, Sanchis, E, Sanders, H, Santoni, C, Saraiva, Jg, Satsunkevitch, I, Says, Lp, Schlereth, J, Seixas, Jm, Sellden, B, Shalanda, N, Shevtsov, P, Shochet, M, Silva, J, Simaitis, V, Sissakian, A, Sjolin, J, Soares, S, Solodkov, A, Solovianov, O, Sosebee, M, Stanek, R, Starchenko, E, Starovoitov, P, Stavina, P, Suk, M, Sykora, I, Tang, F, Tas, P, Teuscher, R, Tokar, S, Topilin, N, Torres, J, Tsulaia, V, Underwood, D, Usai, G, Valkar, S, Varanda, Mj, Vartapetian, A, Vazeille, F, Vichou, I, Vinogradov, V, Vivarelli, I, White, A, Zaitsev, A, and Zenis, T.

Subjects
Scattering cross-section, Physics, Nuclear physics, Energy loss, Particle physics, Muon, Physics and Astronomy (miscellaneous), Energy spectrum, High Energy Physics::Experiment, Nuclear Experiment, Engineering (miscellaneous), Hadron calorimeter
Abstract

The energy spectrum and the cross section of photonuclear interactions of 180 GeV muons in iron were measured at the CERN SPS using prototype modules of the ATLAS hadron calorimeter. The differential cross section $(N_{A}/A)v{d}\sigma/{d}v$ for a muon fractional energy loss $v = \Delta E_{\mu} / E_{\mu}$ was measured in the range 0.1

Published
2003

22. The optical instrumentation of the ATLAS Tile Calorimeter

Author

Abdallah, J., Adragna, P., Alexa, C., Alves, R., Amaral, P., Ananiev, A., Anderson, K., Andresen, X., Antonaki, A., Batusov, V., Bednar, P., Bergeås, Elin, Biscarat, C., Blanch, O., Blanchot, G., Bohm, Christian, Boldea, V., Bosi, F., Bosman, M., Bromberg, C., Budagov, J., Calvet, D., Cardeira, C., Carli, T., Carvalho, J., Cascella, M., Castillo, M. V., Costelo, J., Cavalli-Sforza, M., Cavasinni, V., Cerqueira, A. S., Clément, Christophe, Cobal, M., Cogswell, F., Constantinescu, S., Costanzo, D., Da Silva, P., David, M., Davidek, T., Dawson, J., De, K., Del Prete, T., Diakov, E., Di Girolamo, B., Dita, S., Dolejsi, J., Dolezal, Z., Dotti, A., Downing, R., Drake, G., Efthymiopoulos, I., Errede, D., Errede, S., Farbin, A., Fassouliotis, D., Feng, E., Fenyuk, A., Ferdi, C., Ferreira, B. C., Ferrer, A., Flaminio, V., Flix, J., Francavilla, P., Fullana, E., Garde, V., Gellerstedt, Karl, Giakoumopoulou, V., Giangiobbe, V., Gildemeister, O., Gilewsky, V., Giokaris, N., Gollub, N., Gomes, A., Gonzalez, V., Gouveia, J., Grenier, P., Gris, P., Guarino, V., Guicheney, C., Gupta, A., Hakobyan, H., Haney, M., Hellman, Sten, Henriques, A., Higon, E., Hill, N., Holmgren, Sven-Olof, Hruska, I., Hurwitz, M., Huston, J., Plante, I. Jen-La, Jon-And, Kerstin, Junk, T., Karyukhin, A., Khubua, J., Klereborn, Jonas, Konstantinov, V., Kopikov, S., Korolkov, I., Krivkova, P., Kulchitsky, Y., Kurochkin, Yu, Kuzhir, P., Lapin, V., LeCompte, T., Lefevre, R., Leitner, R., Li, J., Liablin, M., Lokajicek, M., Lomakin, Y., Lourtie, P., Lovas, L., Lupi, A., Maidantchik, C., Maio, A., Maliukov, S., Manousakis, A., Marques, C., Marroquim, F., Martin, F., Mazzoni, E., Merritt, F., Miagkov, A., Miller, R., Minashvili, I., Miralles, L., Montarou, G., Nemecek, S., Nessi, M., Nikitine, I., Nodulman, L., Norniella, O., Onofre, A., Oreglia, M., Palan, B., Pallin, D., Pantea, D., Pereira, A., Pilcher, J., Pina, J., Pinhao, J., Pod, E., Podlyski, F., Portell, X., Poveda, J., Pribyl, L., Price, E., Proudfoot, J., Ramalho, M., Ramstedt, Magnus, Raposeiro, L., Reis, J., Richards, R., Roda, C., Romanov, V., Rosnet, P., Roy, P., Ruiz, A., Rumiantsau, V., Russakovich, N., Da Costa, J. Sa, Salto, O., Salvachua, B., Sanchis, E., Sanders, H., Santoni, C., Santos, J., Saraiva, J. G., Sarri, F., Says, L. -P, Schlager, G., Schlereth, J., Seixas, J. M., Sellden, Björn, Shalanda, N., Shevtsov, P., Shochet, M., Silva, J., Simaitis, V., Simonyan, M., Sissakian, A., Sjölin, Jörgen, Solans, C., Solodkov, A., Solovianov, O., Sosebee, M., Spano, F., Speckmeyer, P., Stanek, R., Starchenko, E., Starovoitov, P., Suk, M., Sykora, I., Tang, F., Tas, P., Teuscher, R., Tischenko, M., Tokar, S., Topilin, N., Torres, J., Underwood, D., Usai, G., Valero, A., Valkar, S., Valls, J. A., Vartapetian, A., Vazeille, F., Vellidis, C., Ventura, F., Vichou, I., Vivarelli, I., Volpi, M., White, A., Zaitsev, A., Zaytsev, Yu, Zenin, A., Zenis, T., Zenonos, Z., Zenz, S., Zilka, B., Abdallah, J., Adragna, P., Alexa, C., Alves, R., Amaral, P., Ananiev, A., Anderson, K., Andresen, X., Antonaki, A., Batusov, V., Bednar, P., Bergeås, Elin, Biscarat, C., Blanch, O., Blanchot, G., Bohm, Christian, Boldea, V., Bosi, F., Bosman, M., Bromberg, C., Budagov, J., Calvet, D., Cardeira, C., Carli, T., Carvalho, J., Cascella, M., Castillo, M. V., Costelo, J., Cavalli-Sforza, M., Cavasinni, V., Cerqueira, A. S., Clément, Christophe, Cobal, M., Cogswell, F., Constantinescu, S., Costanzo, D., Da Silva, P., David, M., Davidek, T., Dawson, J., De, K., Del Prete, T., Diakov, E., Di Girolamo, B., Dita, S., Dolejsi, J., Dolezal, Z., Dotti, A., Downing, R., Drake, G., Efthymiopoulos, I., Errede, D., Errede, S., Farbin, A., Fassouliotis, D., Feng, E., Fenyuk, A., Ferdi, C., Ferreira, B. C., Ferrer, A., Flaminio, V., Flix, J., Francavilla, P., Fullana, E., Garde, V., Gellerstedt, Karl, Giakoumopoulou, V., Giangiobbe, V., Gildemeister, O., Gilewsky, V., Giokaris, N., Gollub, N., Gomes, A., Gonzalez, V., Gouveia, J., Grenier, P., Gris, P., Guarino, V., Guicheney, C., Gupta, A., Hakobyan, H., Haney, M., Hellman, Sten, Henriques, A., Higon, E., Hill, N., Holmgren, Sven-Olof, Hruska, I., Hurwitz, M., Huston, J., Plante, I. Jen-La, Jon-And, Kerstin, Junk, T., Karyukhin, A., Khubua, J., Klereborn, Jonas, Konstantinov, V., Kopikov, S., Korolkov, I., Krivkova, P., Kulchitsky, Y., Kurochkin, Yu, Kuzhir, P., Lapin, V., LeCompte, T., Lefevre, R., Leitner, R., Li, J., Liablin, M., Lokajicek, M., Lomakin, Y., Lourtie, P., Lovas, L., Lupi, A., Maidantchik, C., Maio, A., Maliukov, S., Manousakis, A., Marques, C., Marroquim, F., Martin, F., Mazzoni, E., Merritt, F., Miagkov, A., Miller, R., Minashvili, I., Miralles, L., Montarou, G., Nemecek, S., Nessi, M., Nikitine, I., Nodulman, L., Norniella, O., Onofre, A., Oreglia, M., Palan, B., Pallin, D., Pantea, D., Pereira, A., Pilcher, J., Pina, J., Pinhao, J., Pod, E., Podlyski, F., Portell, X., Poveda, J., Pribyl, L., Price, E., Proudfoot, J., Ramalho, M., Ramstedt, Magnus, Raposeiro, L., Reis, J., Richards, R., Roda, C., Romanov, V., Rosnet, P., Roy, P., Ruiz, A., Rumiantsau, V., Russakovich, N., Da Costa, J. Sa, Salto, O., Salvachua, B., Sanchis, E., Sanders, H., Santoni, C., Santos, J., Saraiva, J. G., Sarri, F., Says, L. -P, Schlager, G., Schlereth, J., Seixas, J. M., Sellden, Björn, Shalanda, N., Shevtsov, P., Shochet, M., Silva, J., Simaitis, V., Simonyan, M., Sissakian, A., Sjölin, Jörgen, Solans, C., Solodkov, A., Solovianov, O., Sosebee, M., Spano, F., Speckmeyer, P., Stanek, R., Starchenko, E., Starovoitov, P., Suk, M., Sykora, I., Tang, F., Tas, P., Teuscher, R., Tischenko, M., Tokar, S., Topilin, N., Torres, J., Underwood, D., Usai, G., Valero, A., Valkar, S., Valls, J. A., Vartapetian, A., Vazeille, F., Vellidis, C., Ventura, F., Vichou, I., Vivarelli, I., Volpi, M., White, A., Zaitsev, A., Zaytsev, Yu, Zenin, A., Zenis, T., Zenonos, Z., Zenz, S., and Zilka, B.

Abstract

The Tile Calorimeter, covering the central region of the ATLAS experiment up to pseudorapidities of +/-1.7, is a sampling device built with scintillating tiles that alternate with iron plates. The light is collected in wave-length shifting (WLS) fibers and is read out with photomultipliers. In the characteristic geometry of this calorimeter the tiles lie in planes perpendicular to the beams, resulting in a very simple and modular mechanical and optical layout. This paper focuses on the procedures applied in the optical instrumentation of the calorimeter, which involved the assembly of about 460,000 scintillator tiles and 550,000 WLS fibers. The outcome is a hadronic calorimeter that meets the ATLAS performance requirements, as shown in this paper., AuthorCount:221

Published
2013
Full Text
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23. Mechanical construction and installation of the ATLAS tile calorimeter

Author

Abdallah, J., Adragna, P., Alexa, C., Alves, R., Amaral, P., Ananiev, A., Anderson, K., Andresen, X., Antonaki, A., Batusov, V., Bednar, P., Behrens, A., Bergeås, Elin, Biscarat, C., Blanch, O., Blanchot, G., Blocki, J., Bohm, Christian, Boldea, V., Bosi, F., Bosman, M., Bromberg, C., Brunel, B., Budagov, J., Calderon, D., Calvet, D., Cardeira, C., Carli, T., Carvalho, J., Cascella, M., Castillo, M. V., Costello, J., Cavalli-Sforza, M., Cavasinni, V., Cerqueira, A. S., Clément, Christophe, Cobal, M., Cogswell, F., Constantinescu, S., Costanzo, D., Da Silva, P., David, M., Davidek, T., Dawson, J., De, K., Del Prete, T., Di Girolamo, B., Dita, S., Dolejsi, J., Dolezal, Z., Dotti, A., Downing, R., Drake, G., Efthymiopoulos, I., Errede, D., Errede, S., Farbin, A., Fassouliotis, D., Feng, E., Fenyuk, A., Ferdi, C., Ferreira, B. C., Ferrer, A., Ferrer, J., Flaminio, V., Flix, J., Francavilla, P., Fullana, E., Garde, V., Gaydee, J. C., Gellerstedt, Karl, Giakoumopoulou, V., Giangiobbe, V., Gildemeister, O., Gilewsky, V., Giokaris, N., Gollub, N., Gomes, A., Gonzalez, V., Gouveia, J., Grenier, P., Gris, P., Grudzinski, J., Guarino, V., Guicheney, C., Gupta, A., Hakobyan, H., Haney, M., Hellman, Sten, Henriques, A., Higon, E., Hill, N., Holmgren, Sven-Olof, Hruska, I., Hurwitz, M., Huston, J., Jen-La Plante, I., Jon-And, Kerstin, Junk, T., Karyukhin, A., Khubua, J., Klereborn, Jonas, Kopikov, S., Korolkov, I., Krivkova, P., Kulchitsky, Y., Kurochkin, Y., Kuzhir, P., Lapin, V., Lasseure, C., LeCompte, T., Lefevre, R., Leitner, R., Li, J., Lyablin, M., Lim, H., Lokajicek, M., Lomakin, Y., Lourtie, P., Lovas, L., Lupi, A., Maidantchik, C., Maio, A., Maliukov, S., Manousakis, A., Marques, C., Marroquim, F., Martin, F., Mazzoni, E., Mergelkuhl, D., Merritt, F., Miagkov, A., Miller, R., Minashvili, I., Miralles, L., Montarou, G., Nemecek, S., Nessi, M., Nikitine, I., Nodulman, L., Norniella, O., Nyman, T., Onofre, A., Oreglia, M., Palan, B., Pallin, D., Pantea, D., Pereira, A., Pilcher, J., Pina, J., Pinhao, J., Pod, E., Podlyski, F., Portell, X., Poveda, J., Pribyl, L., Price, L. E., Proudfoot, J., Ramalho, M., Ramstedt, Magnus, Raposeiro, L., Reis, J., Richards, R., Roda, C., Romanov, V., Rose-Dulcina, L., Rosnet, P., Roy, P., Ruiz, A., Rumiantsau, V., Russakovich, N., da Costa, J. Sa, Salto, O., Salvachua, B., Sanchis, E., Sanders, H., Santoni, C., Santos, J., Saraiva, J. G., Sarri, F., Says, L. -P, Schlager, G., Schlereth, J., Seixas, J. M., Sellden, Björn, Shalanda, N., Shchelchkov, A., Shevtsov, P., Shochet, M., Silva, J., Simaitis, V., Simonyan, M., Sissakian, A., Sjölin, Jörgen, Skrzecz, F., Solans, C., Solodkov, A., Solovianov, O., Sorokina, J., Sosebee, M., Spano, F., Speckmeyer, P., Stanek, R., Starchenko, E., Starovoitov, P., Suk, M., Sykora, I., Tang, F., Tas, P., Teuscher, R., Tokar, S., Topilin, N., Torres, J., Underwood, D., Usai, G., Utkin, V., Valero, A., Valkar, S., Valls, J. A., Vartapetian, A., Vazeille, F., Vellidis, C., Ventura, F., Vichou, I., Vivarelli, I., Volpi, M., White, A., Wood, K., Zaitsev, A., Zenin, A., Zenis, T., Zenonos, Z., Zenz, S., Zilka, B., Abdallah, J., Adragna, P., Alexa, C., Alves, R., Amaral, P., Ananiev, A., Anderson, K., Andresen, X., Antonaki, A., Batusov, V., Bednar, P., Behrens, A., Bergeås, Elin, Biscarat, C., Blanch, O., Blanchot, G., Blocki, J., Bohm, Christian, Boldea, V., Bosi, F., Bosman, M., Bromberg, C., Brunel, B., Budagov, J., Calderon, D., Calvet, D., Cardeira, C., Carli, T., Carvalho, J., Cascella, M., Castillo, M. V., Costello, J., Cavalli-Sforza, M., Cavasinni, V., Cerqueira, A. S., Clément, Christophe, Cobal, M., Cogswell, F., Constantinescu, S., Costanzo, D., Da Silva, P., David, M., Davidek, T., Dawson, J., De, K., Del Prete, T., Di Girolamo, B., Dita, S., Dolejsi, J., Dolezal, Z., Dotti, A., Downing, R., Drake, G., Efthymiopoulos, I., Errede, D., Errede, S., Farbin, A., Fassouliotis, D., Feng, E., Fenyuk, A., Ferdi, C., Ferreira, B. C., Ferrer, A., Ferrer, J., Flaminio, V., Flix, J., Francavilla, P., Fullana, E., Garde, V., Gaydee, J. C., Gellerstedt, Karl, Giakoumopoulou, V., Giangiobbe, V., Gildemeister, O., Gilewsky, V., Giokaris, N., Gollub, N., Gomes, A., Gonzalez, V., Gouveia, J., Grenier, P., Gris, P., Grudzinski, J., Guarino, V., Guicheney, C., Gupta, A., Hakobyan, H., Haney, M., Hellman, Sten, Henriques, A., Higon, E., Hill, N., Holmgren, Sven-Olof, Hruska, I., Hurwitz, M., Huston, J., Jen-La Plante, I., Jon-And, Kerstin, Junk, T., Karyukhin, A., Khubua, J., Klereborn, Jonas, Kopikov, S., Korolkov, I., Krivkova, P., Kulchitsky, Y., Kurochkin, Y., Kuzhir, P., Lapin, V., Lasseure, C., LeCompte, T., Lefevre, R., Leitner, R., Li, J., Lyablin, M., Lim, H., Lokajicek, M., Lomakin, Y., Lourtie, P., Lovas, L., Lupi, A., Maidantchik, C., Maio, A., Maliukov, S., Manousakis, A., Marques, C., Marroquim, F., Martin, F., Mazzoni, E., Mergelkuhl, D., Merritt, F., Miagkov, A., Miller, R., Minashvili, I., Miralles, L., Montarou, G., Nemecek, S., Nessi, M., Nikitine, I., Nodulman, L., Norniella, O., Nyman, T., Onofre, A., Oreglia, M., Palan, B., Pallin, D., Pantea, D., Pereira, A., Pilcher, J., Pina, J., Pinhao, J., Pod, E., Podlyski, F., Portell, X., Poveda, J., Pribyl, L., Price, L. E., Proudfoot, J., Ramalho, M., Ramstedt, Magnus, Raposeiro, L., Reis, J., Richards, R., Roda, C., Romanov, V., Rose-Dulcina, L., Rosnet, P., Roy, P., Ruiz, A., Rumiantsau, V., Russakovich, N., da Costa, J. Sa, Salto, O., Salvachua, B., Sanchis, E., Sanders, H., Santoni, C., Santos, J., Saraiva, J. G., Sarri, F., Says, L. -P, Schlager, G., Schlereth, J., Seixas, J. M., Sellden, Björn, Shalanda, N., Shchelchkov, A., Shevtsov, P., Shochet, M., Silva, J., Simaitis, V., Simonyan, M., Sissakian, A., Sjölin, Jörgen, Skrzecz, F., Solans, C., Solodkov, A., Solovianov, O., Sorokina, J., Sosebee, M., Spano, F., Speckmeyer, P., Stanek, R., Starchenko, E., Starovoitov, P., Suk, M., Sykora, I., Tang, F., Tas, P., Teuscher, R., Tokar, S., Topilin, N., Torres, J., Underwood, D., Usai, G., Utkin, V., Valero, A., Valkar, S., Valls, J. A., Vartapetian, A., Vazeille, F., Vellidis, C., Ventura, F., Vichou, I., Vivarelli, I., Volpi, M., White, A., Wood, K., Zaitsev, A., Zenin, A., Zenis, T., Zenonos, Z., Zenz, S., and Zilka, B.

Abstract

This paper summarises the mechanical construction and installation of the Tile Calorimeter for the ATLAS experiment at the Large Hadron Collider in CERN, Switzerland. The Tile Calorimeter is a sampling calorimeter using scintillator as the sensitive detector and steel as the absorber and covers the central region of the ATLAS experiment up to pseudorapidities +/- 1.7. The mechanical construction of the Tile Calorimeter occurred over a period of about 10 years beginning in 1995 with the completion of the Technical Design Report and ending in 2006 with the installation of the final module in the ATLAS cavern. During this period approximately 2600 metric tons of steel were transformed into a laminated structure to form the absorber of the sampling calorimeter. Following instrumentation and testing, which is described elsewhere, the modules were installed in the ATLAS cavern with a remarkable accuracy for a structure of this size and weight., AuthorCount:234

Published
2013
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24. A precise measurement of 180 GeV muon energy losses in iron

Author

Amaral, P., Amorim, A., Anderson, K., Artikov, A., Benetta, R., Berglund, S., Biscarat, C., Blanch, O., Blanchot, G., Bogush, A., Boehm, C., Boldea, V., Borisov, O., Bosman, M., Bromberg, C., Bravo, S., Budagov Yu, A., Burdin, S., Caloba, L., Camarena, F., Carvalho, J., Castillo, M V., Cavalli Sforza, T., Cavasinni, V., Cerqueira, a S., Chadelas, R., Chirikov Zorin, I., Chlachidze, G., Cobal, M., Cogswell, F., Cologna, S., Constantinescu, S., Costanzo, D., Cowan, B., Crouau, M., Daudon, F., David, M., Davidek, T., Dawson, J., De, K., Delfino, M., del Prete, T., de Santo, A., Di Girolamo, B., Dita, S., Downing, R., Engstroem, M., Errede, D., Errede, S., Fassi, F., Fenyuk, A., Ferrer, A., Flaminio, V., Flix, J., Garabik, R., Gil, I., Gildemeister, O., Glagoley, V., Gomes, A., Gonzalez de La Hoz, S., Grabski, V., Grenier, P., Hakopian, H., Haney, M., Hellman, S., Henriques, A., Hebrard, C., Higon, E., Holik, P., Holmgren, S., Hruska, I., Huston, J., Jo And, K., Kakurin, S., Karyukhin, A., Khubua, J., Kopikov, S., Krivkova, P., Kukhtin, V., Jkulchitsky, Y., Kuzmin, M., Lami, S., Lapin, V., Lazzeroni, C., Lebedev, A., Leitner, R., Li, J., Lomakin, Y., Lomakina, O., Lokajicek, M., Lopez-Amengual, J M., Maio, A., Malyukov, S., Marroquin, F., Mataix, L., Mazzoni, E., Merritt, F S., Miller, R., Minashvili, I., Miralles, L., Montarou, Gerard, Nemecek, S., Nessi, M., Onofre, A., Ostankov, a P., Pacheco, A., Pallin, D., Pantea, D., Paoletti, R., Park, I C., Pilcher, J E., Pinhao, J., Price, L., Proudfoot, J., Pukhov, O., Reinmuth, G., Renzoni, G., Richards, R., Roda, C., Roldan, J., Romance, J B., Romanov, V., Rosnet, P., Ruiz, H., Rusakovitch, N., Sanchis, E., Sanders, H., Santoni, C., Santo, J., Says, L. P., Seixas, J M., Sellden, B., Semenov, A., Shcelchkov, A., Shochet, M., Silva, J., Simaitis, V., Sissakian, a N., Solodkov, A., Solovyanov, O., Sosebee, M., Soustruznik, K., Spano, F., Stanek, R., Starchenko, E., Stavina, Op., Suk, M., Sykora, I., Tang, F., Tas, P., Thaler, J., Thome Filho, Z D., Tokar, S., Topilin, N., Valklar, S., Varanda, M J., Vartapetian, A., Vazeille, F., Vichou, I., Vinogradov, V., Vorozhtsov, S., White, A., Wolters, H., Yamdagni, N., Yarygin, G., Yosef, C., Zaitsev, A., Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and ATLAS

Subjects
[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, Nuclear Experiment
Abstract

The energy loss spectrum of 180 GeV muons has been measured with the 5.6 m long finely segmented Module 0 of the ATLAS hadron tile calorimeter at the CERN SPS. The differential probability dP/d nu per radiation length of a fractional energy loss nu = Delta E/sub mu //E /sub mu / has been measured in the range 0.025 or= nu or=0.97; it is compared with theoretical predictions for energy losses due to bremsstrahlung, production of electron-positron pairs, and energetic knock-on electrons. The iron elastic form factor correction Delta /sub Fe//sup el/=1.63+or-0.17/sub stat/+or-023/sub syst$/ -/sub 0.14 //sup +0.20//sub theor/ to muon bremsstrahlung in the region of no screening of the nucleus by atomic electrons has been measured for the first time, and is compared with different theoretical predictions. (31 refs).

Published
2001

25. ATLAS detector and physics performance: Technical Design Report, 2

Author

Airapetian, A., Grabsky, V., Hakopian, H., Vartapetian, A., Dick, B., Fares, F., Guy, L.P., Moorhead, G.F., Sevior, M.E., Taylor, G.N., Tovey, S.N., Hashemi-Nezhad, R., Peak, L., Saavedra, A., Ulrichs, J., Epp, B., Ghete, V.M., Girtler, P., Kneringer, E., Kuhn, D., Nairz, A., Rudolph, G., Schaller, M., Schweiger, D., Abdinov, O.B., Akhmedov, A., Akhoundov, A., Javadov, N., Khalilzade, F.T., Mekhdiyev, R.R., Oussoubov, Z., Rzayev, H.J., Baturitsky, M.A., Bogush, A.A., Gazizov, A.Z., Gilevsky, V.V., Kulchitsky, Y., Kuzmin, M.V., Levchuk, M.I., Satsunkevich, I.S., Kuzhir, P., Medvedev, V., Pazin, A., Prokoshin, F., Soroko, A., Starovoytov, P., Caloba, L.P., Dos Anjos, A., Gomes, R., Maidantchik, C.L., Marroquim, F., Seixas, J.M., Thome, Z.D., Armstrong, W.W., Burris, W., Davis, R., Gingrich, D.M., Hewlett, J.C., Holm, L., Macpherson, A.L., Mullin, S., Pinfold, J.L., Schaapman, J., Soukup, J., Wampler, L., Axen, D., Armitage, J., Dixit, M., Estabrooks, P., Losty, M., Neuheimer, E., O'Neil, M., Oakham, G., Azuelos, G., Leroy, C., Marullo, F., Mazini, R., Roy, P., Bailey, D.C., Bhadra, S., Martin, J.F., Mayer, J.K., Orr, R.S., Sinervo, P.K., Stairs, G.G., Trischuk, W., Astbury, A., Birney, P., Hodges, T., Langstaff, R., Oram, C., Dobbs, M., Fincke-Keeler, M., Fortin, D., Keeler, R., Lefebvre, M., O'Neil, D., Poffenberger, P., Roney, M., Sobie, R., Aleksa, M., Ambrosini, G., Anderssen, E., Anghinolfi, F., Arnaud, C., Bachy, G., Barberio, E., Benincasa, G., Bergsma, F., Bertinelli, F., Bjorset, L., Bloess, D., Bock, R., Bogaerts, J., Boosten, M., Bremer, J., Burckhart, D., Burckhart, H.J., Butin, F., Cataneo, F., Chesi, E., Chevalley, J.L., Cobal, M., Danielsson, H., Dauvergne, J.P., Dell'Acqua, A., Dittus, F., Dobinson, R., Dobson, M., Drevermann, H., Dudarev, A., Dydak, F., Ellis, N., Fabjan, C.W., Farthouat, P., Fassnacht, P., Fernandez, A., Flegel, W., Francis, D., Froidevaux, D., Giancomini, F., Gianotti, F., Gildemeister, O., Gschwendtner, E.M., Hallgren, B., Hansen, J., Hatch, M., Haug, F., Hauser, R., Hauviller, C., Havet, C., Heeley, R., Henriques, A., Hervas, L., Hoffmann, H.F., Hogbe-Nlend, F., Hoimyr, N., Jarp, S., Jarron, P., Jenni, P., Jones, R., Kantardjian, G., Kaplon, J., Klioutchnikova, T., Knobloch, J., Kulseth, M., Lacasta, C., Lasseur, C., Lehraus, I., Lemeilleur, F., Lichard, P., Linde, F., Lopez, J., Lozano, J., Mandl, M., Mapelli, L., Martin, B., Maugain, J.-M., McLaren, R.A., Meier, D., Meinhard, H., Mitsou, V., Mornacchi, G., Myers, D., Nessi, M., Nicquevert, B., Niinikoski, T., Onions, C., Pailler, P., Passardi, G., Petersen, J., Placci, A., Poppleton, A., Posch, C., Poulard, G., Price, M., Riedler, P., Roe, S., Rohrbach, F., Rudge, A., Schmid, P., Schuler, G., Schwick, C., Shears, T., Simion, S., Soulhat, J., Spiwoks, R., Stavrianakou, M., Stavropoulos, G., Szeless, B., Tapprogge, S., Tartarelli, G.F., Ten Kate, H., Teterin, V., Tischhauser, H., Treichel, M., Tremblet, L., Tuura, L., Turala, M., Unel, G., Van der Bij, H., Vincke, H., von Boehn-Bucholz, R., Voss, R., Vreeswijk, M., Vuillemin, V., Weilhammer, P., Werner, P., Witzeling, W., Wotschack, J., Chen, C., Chen, T-Y., Cheng, S., Feng, C., Fu, Y., Kong, F., Li, H., Liu, T., Lu, W.D., Ma, J.M., Meng, X., Ouyang, Q., Qi, M., Tong, G.L., Wang, C., Xie, Y.G., Xue, L., Xu, G.F., Yang, B., Yang, T., Ye, B., Yu, X.Q., Zhang, B., Zhang, N., Zhang, Q.J., Zhao, J., Jinan, Bohm, J., Hakl, F., Hrivnac, J., Jirina, M., Lednicky, R., Lokajicek, M., Mares, J.J., Nemecek, S., Rizek, S., Sicho, P., Simak, V., Stastny, J., Stedron, M., Vanickova, M., Vrba, V., Weichert, J., Zitek, K., Davidek, T., Dolejsi, J., Dolezal, Z., Kucera, M., Leitner, R., Soustruznik, K., Suk, M., Tas, P., Trka, Z., Valkar, S., Wilhelm, I., Zdrazil, M., Jakubek, J., Kubasta, J., Ota, J., Pospisil, S., Sinor, M., Sodomka, J., Sopko, B., Stekl, I., Tomiak, Z., Dam, M., Hansen, J.D., Hansen, J.R., Hansen, P., Aubert, B., Beaugiraud, B., Billat, C., Boniface, J., Cailles, M., Chollet-LeFlour, F., Colas, J., Duchesneau, A., Dumont-Dayot, N., Girard, C., Gouanere, M., Jezequel, S., Kambara, H., Lafaye, R., Lesueur, J., Masserot, A., Massol, N., Moynot, M., Perrodo, P., Perrot, G., Prast, J., Riccadonna, X., Sauvage, G., Thion, J., Wingerter-Seez, I., Zitoun, R., Zolnierowski, Y., Biscarat, C., Chadelas, R., Crouau, M., Daudon, F., Grenier, P., Guicheney, Ch., Hebrard, C., Lefevre, R., Montarou, G., Pallin, D., Podlyski, F., Reinmuth, G., Santoni, C., Says, L.P., Vazeille, F., Andrieux, M.L., Collot, J., Dzahini, D., Ferrari, A., Hostachy, J.Y., Martin, Ph., Pouxe, J., Rabier, C., Rey-Campagnolle, M., De Saintignon, P., Stassi, P., Bee, C., Blanquart, L., Breugnon, P., Calvet, D., Clemens, J-C., Delpierre, P., Dinkespiler, B., Djama, F., Duval, P-Y., Etienne, F., Fede, E., Hallewell, G., Henry-Couannier, F., Hinz, L., Karst, P., Laugier, D., Le Van Suu, A., Martin, L., Martin, O., Meessen, C., Mirea, A., Monnier, E., Mouthuy, T., Nacasch, R., Nagy, E., Negroni, S., Nicod, D., Olivier, C., Pralavorio, P., Quian, Z., Repetti, B., Rondot, C., Rousseau, D., Rozanov, A., Sauvage, D., Tisserant, S., Touchard, F., Vacavant, L., Valin, I., Vigeolas, E., Wielers, M., Arnault, C., Auge, E., Barrand, G., Belot, G., Beney, J.L., Blaquiere, M., Bonivento, W., Bourdarios, C., Breton, D., Chollet, C., Coulon, J-P., Cros, Ph., De la Taille, C., Delebecque, P., Falleau, I., Fallou, A., Fournier, D., Grivaz, J-F., Imbert, P., Jacquier, Y., Mace, G., Martin-Chassard, G., Mencik, M., Merkel, B., Noppe, J-M., Parrour, G., Perus, A., Petroff, P., Puzo, P., Richer, J-P., Schaffer, A-C., Seguin-Moreau, N., Serin, L., Tocut, V., Vales, F., Veillet, J-J., Vernay, E., Zerwas, D., Astesan, F., Bertoli, W., Canton, B., David, J., Fichet, S., Fleuret, F., Imbault, D., Lacour, D., Laforge, B., Le Dortz, O., Martin, D., Poggioli, L., Rossel, F., Schwemling, P., Amadon, A., Bauer, F., Belorgey, J., Berriaud, C., Berthier, R., Borgeaud, P., Bystricky, J., Cacaut, D., Chalifour, M., Chevalier, L., Cloue, O., Dael, A., Delagnes, E., Desages, F., Durand, D., Ernwein, J., Gachelin, O., Gallet, B., Gastineau, B., de Girolamo, P., Guyot, C., Hansl-Kozanecka, T., Hubbard, J.R., Huet, M., Joudon, A., Juster, F.P., Kiourkos, S., Kozanecki, W., Laporte, J.F., Le Coreller, A., Le Du, P., Lesmond, C., Lugiez, F., Machefert, F., Mandjavidze, I., Mansoulie, B., Mayri, C., Molinie, F., Mur, M., Pabot, Y., Pascual, J., Perrin, P., Ponsot, P., Rey, J.M., Rouger, M., Schuller, J.P., Schune, Ph., Schwindling, J., Sun, Z., Taguet, J.P., Teiger, J., Thooris, B., Tirler, R., Van Hille, H., Virchaux, M., Chikovani, L., Chiladze, B., Djobava, T., Gabunia, L., Gogiberidze, G., Grigalashvili, T., Khelashvili, A., Khorguashvili, Z., Khubua, J., Kipiani, K., Koshtoev, V., Liparteliani, A., Metreveli, Z., Mosidze, M., Salukvadze, R., Sopromadze, D., Topchishvili, L., Ackers, M., Andre, F., Andreazza, A., Comes, G., Fischer, P., Geich-Gimbel, C., Klasen, V., Keil, M., Kobel, M., Kuhl, T., Meuser, S., Ockenfels, W., Stockmanns, T., Treis, J., Wermes, N., Geiser, A., Goessling, C., Huegging, F., Wuestenfeld, J., Wunstorf, R., Baer, Th., Chen, J., Ebling, D.G., Herten, G., Irsigler, R., Kollefrath, M., Landgraf, U., Lauxtermann, S., Ludwig, J., Mohr, W., Paschhoff, V., Rehmann, V., Rolker, B., Runge, K., Schaefer, F., Scherberger, G., Schmid, T., Webel, M., Weber, C., Geweniger, C., Hanke, P., Kluge, E.-E., Mahboubi, K., Meier, K., Pfeiffer, U., Putzer, A., Schumacher, C., Tittel, K., Wunsch, M., Fuchs, K., Geib, K.H., Jakobs, K., Kleinknecht, K., Koepke, L., Marschalkowski, E., Merle, K., Othegraven, R., Quast, G., Renk, B., Schaefer, U., Walkowiak, W., Zeitnitz, C., Kornmesser, K., Kugel, A., Lay, R., Ludvig, J., Maenner, R., Noffz, K-H., Ruehl, S., Sessler, M., Simmler, H., Singpiel, H., Chouridou, S., Deile, M., Kortner, O., Hessey, N.P., Schaile, D., Staude, A., Strohmer, R., Trefzger, T., Ackermann, K., Aderholz, M., Andricek, L., Blum, W., Bratzler, U., Brettel, H., Dietl, H., Dulny, B., Fent, J., Gruhn, C., Hauff, D., Koffeman, E., Kroha, H., Lutz, G., Manz, A., Moser, H.-G., Oberlack, H., Ostapchuk, A., Richter, R., Richter, R.H., Schacht, P., Schael, S., Soergel, V., Stenzel, H., Striegel, D., Tribanek, W., Holder, M., Schoefer, B., Ziolkowski, M., Becks, K.H., Braun, H., Drees, J., Gerlach, P., Glitza, K.W., Gregor, I.M., Hamacher, K., Kersten, S., Lenzen, G., Linder, C., Thadome, J., Wahlen, H., Dris, M., Filippas, A., Fokitis, E., Gazis, E.N., Katsoufis, E., Maltezos, S., Papadopoulou, T., Fasssouliotis, D., Giokaris, N., Ioannou, P., Kourkoumelis, C., Pancheluga, V., Petridis, A., Tatsis, S., Tzanakos, G.S., Vassiliou, M., Bouzakis, C., Chardalas, M., Dedoussis, S., Efstathiou, K., Lagouri, Th., Liolios, A., Paschalias, P., Petridou, C., Sampsonidis, D., Vichou, I., Zamani, M., Dado, S., Harel, A., Landesman, H., Lupu, N., Robins, S., Rozen, Y., Tarem, S., Abramowicz, H., Alexander, G., Bella, G., Benary, O., Dagan, S., Etzion, E., Grunhaus, J., Oren, Y., Breskin, A., Chechik, R., Duchovni, E., Eisenberg, Y., Gross, E., Hass, M., Karshon, U., Lellouch, D., Levinson, L., Mikenberg, G., Ayad, R., Capua, M., Lagatta, A., La Rotonda, L., Schioppa, M., Susinno, G., Valdata-Nappi, M., Bilokon, H., Cerutti, F., Chiarella, V., Curatolo, M., Dulach, B., Esposito, B., Ferrer, M.L., Maccarrone, G., Moccia, S., Pace, E., Pepe-Altarelli, M., Spitalieri, M., Zuffranieri, F., Barberis, D., Beccherle, R., Caso, C., Dameri, M., Darbo, G., Gagliardi, G., Gemme, C., Morettini, P., Musico, P., Olcese, M., Osculati, B., Parodi, F., Pozzo, A., Ridolfi, G., Rossi, L., Sette, G., Creti, P., Gorini, E., Grancagnolo, F., Palamara, O., Petrera, S., Primavera, M., Acerbi, E., Aleppo, M., Alessandria, F., Battistoni, G., Broggi, F., Caccia, M., Camin, D., Cavalli, D., Costa, G., Fanti, M., LaBanca, N., Lari, T., Mandelli, L., Mazzanti, M., Meroni, C., Perini, L., Ragusa, F., Resconi, S., Sala, P., Troncon, C., Vanini, S., Vegni, G., Volpini, G., Aloisio, A., Alviggi, M.G., Cevenini, F., Chiefari, G., De Asmundis, R., Merola, L., Napolitano, M., Patricelli, S., Cambiaghi, M., Conta, C., Ferrari, R., Fraternali, M., Lanza, A., Livan, M., Negri, A., Polesello, G., Rimoldi, A., Vercesi, V., Cavasinni, V., Cologna, S., Costanzo, D., Del Prete, T., Di Girolamo, B., Flaminio, V., Lami, S., Marrocchesi, P.S., Mazzoni, E., Paoletti, R., Renzoni, G., Roda, C., Spano, F., Suglia, R., Usai, G., Bagnaia, P., Bini, C., Caloi, R., Cardini, A., Cavallari, A., Ciapetti, G., De Zorzi, G., DiMattia, A., Falciano, S., Gauzzi, P., Gentile, S., Lacava, F., Luci, C., Luminari, L., Marzano, F., Mirabelli, G., Nisati, A., Petrolo, E., Pontecorvo, L., Veneziano, S., Zanello, L., Aielli, G., Baranov, S., Camarri, P., Cardarelli, R., Di Ciaccio, A., Liberti, B., Paoloni, A., Santonico, R., Bacci, C., Baroncelli, A., Ceradini, F., Farilla, A., Iodice, M., Orestano, D., Pastore, F., Spiriti, E., Stanescu, C., Cauz, D., D'Auria, S., De Angelis, A., Pauletta, G., Santi, L., Scuri, B., Waldner, F., del Papa, C., Tanaka, S., Asai, M., Iwata, Y., Ohsugi, T., Amako, K., Arai, Y., Fujii, H., Haruyama, T., Ikeno, M., Iwasaki, H., Kanzaki, J., Kohriki, T., Kondo, T., Manabe, A., Morita, Y., Nomachi, M., Ohska, T.K., Sasaki, O., Sasaki, T., Terada, S., Unno, Y., Watase, Y., Yamamoto, A., Yasu, Y., Kawagoe, K., Kurashige, H., Nozaki, M., Takeda, H., Sakamoto, H., Sasao, N., Takashima, R., Nagasaka, Y., Tanaka, Y., Nagamatsu, M., Yoshida, H., Takeshita, T., Hasegawa, Y., Homma, K., Imori, M., Kawamoto, T., Kobayashi, T., Fukunaga, C., Hamatsu, R., Emura, T., Chakir, H., Cherkaoui, R., Goujdami, D., El Kacimi, M., Hoummada, A., Saidi, H., Sayouty, E., Bobbink, G.J., Bos, K., Boterenbrood, H., Buis, E.J., Dankers, R.J., Daum, C., Groenstege, H., Hartjes, F., Hendriks, P., Heubers, W., Kaan, B., Kieft, G.N.M., Kluit, P., Kluit, R., Massaro, G.G.G., Meddeler, G., Peeters, S., Reichold, A., Rewiersma, P.A.M., Schuijlenburg, H., Spelt, J., Vermeulen, J.C., Werneke, P., Woudstra, M., van Eijk, B., van der Graaf, H., Brouwer, C., Crijns, F.J.G.H., Dijkema, J.A., De Jong, S.J., Kittel, W., Klok, P.F., Lavrijsen, W.T.L.P., Koenig, A.C., Metzger, W.J., Pols, G.-J., Schotanus, D.J., Wijnen, Th.A.M., Eigen, G., Frodesen, A.G., Klovning, A., Stugu, B., Bugge, L., Buran, T., Dorholt, O., Kristiansen, H., Madsen, R.A., Marshal, A., Midttun, G., Read, A.L., Rohne, O.M., Stapnes, S., Strandlie, A., Sundal, B., Blocki, J., Bocian, D., Gadomski, S., Gornicki, E., Godlewski, J., Hajduk, Z., Iwanski, W., Kaczmarska, A., Kisielewski, B., Korcyl, K., Madeyski, B., Malecki, P., Moszczynski, A., Olszowska, J., Piotrzkowski, K., Richter-Was, E., Sapinski, M., Wolter, M., Dabrowski, W., Grybos, P., Idzik, M., Jagielski, S., Jelen, K., Kiesilewska, D., Koperny, S., Kowalski, T., Rulikowska-Zarebska, E., Amaral, P., Amorim, A., Carvalho, J., Casarejos, E., David, M., Gomes, A., Gomes, J., Ivaniouchenkov, I., Maio, A., Maneira, M., Martins, J.P., Onofre, A., Pinhao, J., Santos, J., Silva, J., Varanda, M., Wolters, H., Portuguesa U., Figueira da Foz & Nova U., Lisboa, Alexa, C., Arsenescu, R., Badescu, E., Boldea, V., Caprini, I., Caprini, M., Constantin, F., Constantinescu, S., Dita, P., Dita, S., Micu, A., Micu, L., Niculescu, M., Pantea, D., Radu, A., Artamonov, A., Epchtein, V., Gorbunov, P., Gurin, R., Jemanov, V., Khovansky, V., Koutchenkov, A., Kruchinin, S., Maslennikov, A., Ryabinin, M., Shatalov, P., Tsoukerman, I., Zaitsev, V., Zeldovich, S., Akimov, A., Belov, M., Blagov, M., Fedorchuk, R., Gavrilenko, I., Kaioumov, F., Komar, A., Konovalov, S., Kopytine, M., Mouraviev, S., Popov, L., Shikanyan, A., Shmeleva, A., Snesarev, A., Speransky, M., Sulin, V., Tikhomirov, V., Vassilieva, L., Yakimenko, M., Bondarenko, V., Dolgoshein, B., Konstantinov, A., Romaniouk, A., Semenov, S., Smirnov, S., Sosnovtzev, V., Bashindjagian, G.L., Basiladze, S.G., Berejnoi, A., Erasov, A.B., Grishkevich, Y., Karmanov, D.E., Kramarenko, V.A., Larichev, A.N., Melikhov, D.I., Merkin, M.M., Nikitin, N.V., Rizatdinova, F.K., Selikov, A.V., Sivoklokov, S.Yu., Smirnova, L.N., Zverev, E.G., Batrakov, A., Chekhtman, A., Fedotov, M., Gaponenko, I., Klimenko, S., Kollegov, M., Kozlov, V., Kuper, E., Merzlyakov, Y., Panin, V., Shamov, A., Telnov, V., Tikhonov, Y., Velikzhanin, Y., Amelin, D.V., Ammosov, V.V., Antipov, Yu.M., Batarin, V., Bogoliubsky, M.Yu., Borissov, A.A., Borissov, E., Bozko, N.I., Bryzgalov, V.V., Chekulaev, S.V., Denisov, S.P., Dushkin, A.Yu., Fakhroutdinov, R., Fenyuk, A.B., Gapienko, V.A., Gilitsky, Yu.V., Goryatchev, V., Gouz, Yu.P., Karyukhin, A.N., Khokhlov, Yu.A., Kirsanov, M.M., Kiryunin, A.E., Klyukhin, V., Kojine, A., Kononov, A.I., Konstantinov, V., Kopikov, S.V., Korotkov, V.A., Kostrikov, M.E., Kostyukhin, V.V., Kravtsov, V.I., Kulemzin, A., Kurchaninov, L.L., Lapin, V.V., Levitsky, M.L., Los, S., Maximov, V., Miagkov, A.G., Mikhailin, V.N., Minaenko, A.A., Moiseev, A.M., Onuchin, V.A., Pleskach, A.V., Salomatin, Yu.I., Senko, V.A., Shein, I., Soldatov, A.P., Solodkov, A.A., Solovianov, O.V., Starchenko, E.A., Sviridov, Yu., Sytnik, V.V., Tchmil, V., Tchountonov, A., Tikhonov, V.V., Tsyupa, Yu., Usenko, E., Vorobiev, A.P., Vovenko, A.S., Zaets, V.G., Zaitsev, A.M., Zimin, S., Zmouchhko, V., Fedin, O., Filimonov, V., Gavrilov, G., Ivochkin, V., Khomoutnikov, V., Kolos, S., Krivchitch, A., Lochak, I., Maleev, V., Nadtochy, A., Patritchev, S., Prokofiev, D., Riabov, J., Schegelsky, V., Soloviev, I., Spiridenkov, E., Zalite, A., Alexandrov, I., Alexeev, G., Alikov, B., Anosov, V., Astvatsaturov, A., Azhgirei, L., Backovic, S., Boyko, I., Budagov, J., Chelkov, G., Cheplakov, A., Chirikov-Zorin, I., Chlachidze, G., Dedovich, D., Dodonov, V., Evtukhovich, P., Fedorov, A., Feshenko, A., Flyagin, V., Glagolev, V., Golikov, V., Golubykh, S., Gongadze, A., Gornushkin, Y., Gostkin, M., Iamburenko, V., Ignatenko, M., Juravlev, N., Kakurin, S., Kallinikov, V., Kalinichenko, V., Kazarinov, M., Kazymov, A., Kekelidze, G., Khasanov, A., Khomenko, B., Khovansky, N., Kotov, S., Kotov, V., Kovtun, V., Krumstein, Z., Kukhtin, V., Kuznetsov, O., Ladygin, E.U., Lazarev, A., Lebedev, A., Ljablin, M., Lomakin, Y., Malyshev, V., Malyukov, S., Manjavidze, D., Merekov, Y., Minashvili, I., Nikolenko, M., Nozdrin, A., Olshevski, A., Peshekhonov, V., Pisarev, I., Podkladkin, S., Pose, R., Potrap, I., Pukhov, O., Romanov, V., Rumyantsev, V., Russakovich, N., Ryabchenko, K., Salihagic, D., Savin, I., Scheltckov, A., Sedykh, Y., Semenov, A., Senchishin, V., Shabalin, D., Shalyugin, A., Shigaev, V., Shilov, S., Simic, M., Sissakian, A., Snyatkov, V., Sorokina, J., Tchepournov, V., Tkachev, L., Tokmenin, V., Topilin, N., Tskhadadze, E., Usov, Y., Vertogradov, L., Vinogradov, V., Vorozhtsov, S., Yarygin, G., Zhuravlev, V., Ban, J., Bruncko, D., Chochula, P., Chytracek, R., Dubnicka, S., Dubnickova, A., Ferencei, J., Garabik, R., Holik, P., Jusko, A., Kladiva, E., Kocper, B., Kubinec, P., Kurca, T., Luptak, M., Masarik, J., Povinec, P., Rosinsky, P., Stanicek, J., Stavina, P., Strizenec, P., Sykora, I., Tokar, S., Vanko, J., Cindro, V., Filipcic, A., Kramberger, G., Mandic, I., Mikuz, M., Tadel, M., Zontar, D., Blanch, O., Blanchot, G., Bosman, M., Cavalli-Sforza, M., Crespo, J.M., Dosil, M., Fernandez, E., Flix, J., Korolkov, I., Martinez, M., Miralles, Ll., Ostankov, A., Pacheco, A., Pena, J.C., Zamora, Y., Barreiro, F., Del Peso, J., Labarga, L., Ballester, F., Bernabeu, J., Camarena, F., Campabadal, F., Carrasco, R., Castillo, M.V., Costa, M.J., Ferrer, A., Fuster, J., Garcia, C., Gonzalez, V., Gonzalez de la Hoz, S., Higon, H., Lopez, J.M., Martinez, C., Modesto, P., Moreno, A., Lozano, M., Roldan, J., Romance, J.B., Ros, E., Salt, J., Sanchez, J., Sanchis, E., Santander, J., Ullan, M., Akesson, T., Almehed, S., Carling, H., Danielson, H., Eerola, P., Egede Anderson, U., Hedberg, V., Jarlskog, G., Korsmo, H., Lorstad, B., Lundberg, B., Mjornmark, U., Akerman, D., Carlson, P., Clement, C., Leven, S., Lund-Jensen, B., Pearce, M., Soderqvist, J., Vanyashin, A., Berglund, S., Bohm, C., Engstrom, M., Hellman, S., Holmgren, S-O., Johansson, E., Jon-And, K., Klereborn, J., Sellden, B., Silverstein, S., Sjolin, J., Yamdagni, N., Bingefors, N., Botner, O., Brenner, R., Bystrom, O., Coadou, Y., Damet, J., Ekelof, T., Gustafsson, L., Hallgren, A., Kullander, S., Staaf, P., Beck, H.P., Borer, K., Hess, M., Lehmann, G., Mommsen, R., Pretzl, K., Bonino, R., Clark, A.G., Couyoumtzelis, C., Demierre, Ph., Efthymiopoulos, I., Kowalewski, R., La Marra, D., Leger, A., Perrin, E., Vuandel, B., Wu, X., Atag, A., Cakir, O., Meric, N., Sultansoy, S., Turk, I., Ulvi Yilmazer, A., Arik, E., Celik, O., Cetin, S.A., Conka, T., Hacinliyan, A., Kurtulus, O., Mailov, A., Nurdan, K., Tanoren, B., Bright-Thomas, P., Charlton, D.G., Dowell, J.D., Garvey, J., Hillier, S.J., Homer, R.J., Jovanovic, P., Kenyon, I.R., McMahon, T.J., O'Neale, S.W., Staley, R.J., Watkins, P.M., Watson, A.T., Watson, N.K., Wilson, J.A., Batley, J.R., Carter, J.R., Drage, L., Goodrick, M.J., Hill, J.C., Munday, D.J., Parker, M.A., Robinson, D., Wyllie, K.H., Boyle, O., Candlin, D.J., Candlin, E.R.S., Knowles, I.G., Doyle, A.T., Flavell, A.J., Lynch, J.G., Martin, D.J., O'Shea, V., Raine, C., Saxon, D.H., Skillicorn, I.O., Smith, K.M., Brodbeck, T.J., Chilingarov, A., Henderson, R.C.W., Hughes, G., Jones, R.W.L., Ratoff, P.N., Sloan, T., Smizanska, M., Allport, P.P., Booth, P.S.L., Carroll, L.J., Cooke, P.A., Greenall, A., Houlden, M.A., Jackson, J.N., Jones, T.J., King, B.T., Maxfield, S.J., Moreton, A., Smith, N.A., Sutcliffe, P., Turner, P.R., Wells, D., Beck, G.A., Carter, A.A., Eisenhandler, E.F., Hughes, D.M., Kyberd, P., Landon, M., Lloyd, S.L., Newman-Coburn, D., Pentney, J.M., Pritchard, T.W., Thompson, G., Blair, G.A., George, S., Green, B.J., Medcalf, T., Strong, J.A., Anderson, B., Attree, D., Butterworth, J., Charalambous, A., Clarke, P., Cranfield, R., Crone, G., Fraser, J., Hayes, D., Hoare, T., Jones, T., Lane, J., Postranecky, M., Sherwood, P., Wheeler, S., Duerdoth, I.P., Dunne, P.W., Foster, J.M., Freestone, J., Hughes-Jones, R.E., Ibbotson, M., Kerr, A., Kolya, S.D., Loebinger, F.K., Marshall, R., Mercer, D., Pater, J., Snow, S., Thompson, R.J., Buira-Clarke, D., Cashmore, R., Coe, P., Hawes, B.M., Hill, J., Holmes, A., Howell, D., Huffman, B.T., Kundu, N., Loken, J.G., Mitra, A., Nickerson, R.B., Reichold, A.R., Renton, P.B., Segar, A.M., Wastie, R.L., Weidberg, A.R., Apsimon, R.J., Baines, J.T., Baynham, D.E., Botterill, D.R., Clifft, R.W., Edwards, M., English, R.L., Fisher, S.M., Gee, C.N.P., Gibson, M.D., Gillman, A.R., Greenfield, D., Hart, J.C., Hatley, R.W., Haywood, S.J., Hill, D.L., McCubbin, N.A., Middleton, R.P., Morrissey, M.C., Murray, W.J., Nichols, A., Norton, P.R., Payne, B.T., Perera, V.J.O., Phillips, P.W., Pilling, A., Saunders, B.J., Shah, T.P., Tappern, G.J., Tyndel, M., White, D.J., Wickens, F.J., Booth, C.N., Buttar, C.M., Combley, F.H., Dawson, I., Grigson, C., Lehto, M.H., Alam, S., Athar, B., Mahmood, A., Timm, S., Wappler, F., Zhichao, L., Berger, E.L., Blair, R., Dawson, J., Drake, G., Guarino, V., Hill, N., May, E.N., Nodulman, L.J., Price, L.E., Proudfoot, J., Schlereth, J.L., Stanek, R., Wagner, R.G., Wicklund, A.B., Yoshida, R., Cheu, E., Embry, T., Johns, K., Loch, P., Rutherfoord, J., Savine, A., Shaver, L., Shupe, M., Steinberg, J., Tompkins, D., De, K., Gallas, E., Li, J., Sosebee, M., Stephens, R., White, A., Barnett, M., Bintinger, D., Ciocio, A., Einsweiler, K., Gilchriese, M., Haber, C., Hinchliffe, I., Joshi, A., Loken, S., Marchesini, R., Milgrome, O., Niggli, H., Palaio, N., Richardson, J., Shapiro, M., Siegrist, J., Spieler, H., Trilling, G., Ahlen, S., Hazen, E., Shank, J., Simmons, E., Whitaker, J.S., Zhou, B., Behrends, S., Bensinger, J.R., Blocker, C., Hashemi, K., Kirsh, L.E., Wellenstein, H., Alforque, S., Barratt, R., Citterio, M., Gordeev, A., Gordon, H., Graf, N., Gratchev, V., Kandasamy, A., Koehler, J., Kotcher, J., Lissauer, D., Ma, H., Makowiecki, D., Murtagh, M.J., Norton, S., O'Connor, P., Paige, F., Polychronakos, V., Protopopescu, S., Radeka, V., Rahm, D.C., Rajagopalan, S., Rescia, S., Smith, G., Sondericker, J., Stephani, D., Stumer, I., Takai, H., Tcherniatine, V., Yu, B., Anderson, K., Bellerive, A., Blucher, E., Glenzinsky, D., Merritt, F., Oreglia, M., Pilcher, J., Pod, E., Sanders, H., Shochet, M., Tang, F., Teuscher, R., Wu, H., Cartiglia, N., Cunitz, H., Dodd, J., Gara, J., Leltchouk, M., Parsons, J., Seman, M., Shaevitz, M., Sippach, W., Willis, W., Zhang, L., Ebenstein, W.L., Goshaw, A.T., Lee, A.M., Oh, S.H., Robertson, W.J., Wang, C.H., Assamagan, K.A., Baker, O.K., McFarlane, W.K., Brandenburg, G., Feldman, G.J., Felt, N., Franklin, M.E.B., Huth, J., Oliver, J., Riegler, W., Callahan, J., Hanson, G., Luehring, F., Ogren, H., Rust, D.R., Fahlund, T., Hackett, C., Hall, R., Lankford, A.J., Pier, S., Schernau, M., Stoker, D., Haridas, P., Osborne, L.S., Paradiso, J.A., Pless, I.A., Taylor, F.E., Wadsworth, B.F., Ball, R., Campbell, M., Chapman, J.W., Diehl, E., Goldfarb, S., Hou, S., Kouba, D., Levin, D., McKee, S., Neal, H.A., Qian, J., Schick, H., Tarle, G., Thun, R., Weaverdyck, C., Abolins, M., Brock, R., Bromberg, C., Ermoline, Y., Huston, J., Linnemann, J., Miller, R., Pineiro, B., Pope, B.G., Richards, R., Weerts, H., Gold, M., Gorfine, G., Hoeferkamp, M., Seidel, S., Fortner, M., Sirotenko, V.I., Willis, S.E., Gan, K.K., Honscheid, K., Kagan, H., Kass, R., Boyd, R., Gutierrez, P., McMahon, T., Severini, H., Skubic, P., Snow, J., Strauss, M., Dressnandt, N., Keener, P., Newcomer, F.M., Van Berg, R., Williams, H.H., Cleland, W.E., Mcdonald, J.E., Paolone, V., Rabel, J., Zuk, G., England, D., Haelen, T., Slattery, P., Dorfan, D., Dubbs, T., Grillo, A., Heusch, C., Kashigin, S., Litke, A., Sadrozinski, H., Seiden, A., Spencer, E., Webster, A., Chou, T.-M., Evans, G., Stroynowski, R., Ye, J., Engelmann, R., Grannis, P., Hobbs, J., Jung, C.K., McCarthy, B., Rijssenbeek, M., Schamberger, D., Yanagisawa, C., Mann, A., Milburn, R., Napier, A., Sliwa, K., Errede, D., Errede, S., Haney, M.J., Thaler, J., Burnett, T.H., Cook, V., Daly, C., Davisson, R., Forbush, D., Guldenmann, H., Lubatti, H.J., Mockett, P.M., Rothberg, J., Zhao, T., Fasching, D., Gonzalez, S., Jared, R.C., Pan, Y.B., Scott, I.J., Wu, S.L., Yamartino, J.M., and Zobernig, G.

Subjects
Detectors and Experimental Techniques
Published
1999

26. ATLAS detector and physics performance: Technical Design Report, 1

Author

Airapetian, A., Grabsky, V., Hakopian, H., Vartapetian, A., Dick, B., Fares, F., Guy, L.P., Moorhead, G.F., Sevior, M.E., Taylor, G.N., Tovey, S.N., Hashemi-Nezhad, R., Peak, L., Saavedra, A., Ulrichs, J., Epp, B., Ghete, V.M., Girtler, P., Kneringer, E., Kuhn, D., Nairz, A., Rudolph, G., Schaller, M., Schweiger, D., Abdinov, O.B., Akhmedov, A., Akhoundov, A., Javadov, N., Khalilzade, F.T., Mekhdiyev, R.R., Oussoubov, Z., Rzayev, H.J., Baturitsky, M.A., Bogush, A.A., Gazizov, A.Z., Gilevsky, V.V., Kulchitsky, Y., Kuzmin, M.V., Levchuk, M.I., Satsunkevich, I.S., Kuzhir, P., Medvedev, V., Pazin, A., Prokoshin, F., Soroko, A., Starovoytov, P., Caloba, L.P., Dos Anjos, A., Gomes, R., Maidantchik, C.L., Marroquim, F., Seixas, J.M., Thome, Z.D., Armstrong, W.W., Burris, W., Davis, R., Gingrich, D.M., Hewlett, J.C., Holm, L., Macpherson, A.L., Mullin, S., Pinfold, J.L., Schaapman, J., Soukup, J., Wampler, L., Axen, D., Armitage, J., Dixit, M., Estabrooks, P., Losty, M., Neuheimer, E., O'Neil, M., Oakham, G., Azuelos, G., Leroy, C., Marullo, F., Mazini, R., Roy, P., Bailey, D.C., Bhadra, S., Martin, J.F., Mayer, J.K., Orr, R.S., Sinervo, P.K., Stairs, G.G., Trischuk, W., Astbury, A., Birney, P., Hodges, T., Langstaff, R., Oram, C., Dobbs, M., Fincke-Keeler, M., Fortin, D., Keeler, R., Lefebvre, M., O'Neil, D., Poffenberger, P., Roney, M., Sobie, R., Aleksa, M., Ambrosini, G., Anderssen, E., Anghinolfi, F., Arnaud, C., Bachy, G., Barberio, E., Benincasa, G., Bergsma, F., Bertinelli, F., Bjorset, L., Bloess, D., Bock, R., Bogaerts, J., Boosten, M., Bremer, J., Burckhart, D., Burckhart, H.J., Butin, F., Cataneo, F., Chesi, E., Chevalley, J.L., Cobal, M., Danielsson, H., Dauvergne, J.P., Dell'Acqua, A., Dittus, F., Dobinson, R., Dobson, M., Drevermann, H., Dudarev, A., Dydak, F., Ellis, N., Fabjan, C.W., Farthouat, P., Fassnacht, P., Fernandez, A., Flegel, W., Francis, D., Froidevaux, D., Giancomini, F., Gianotti, F., Gildemeister, O., Gschwendtner, E.M., Hallgren, B., Hansen, J., Hatch, M., Haug, F., Hauser, R., Hauviller, C., Havet, C., Heeley, R., Henriques, A., Hervas, L., Hoffmann, H.F., Hogbe-Nlend, F., Hoimyr, N., Jarp, S., Jarron, P., Jenni, P., Jones, R., Kantardjian, G., Kaplon, J., Klioutchnikova, T., Knobloch, J., Kulseth, M., Lacasta, C., Lasseur, C., Lehraus, I., Lemeilleur, F., Lichard, P., Linde, F., Lopez, J., Lozano, J., Mandl, M., Mapelli, L., Martin, B., Maugain, J.-M., McLaren, R.A., Meier, D., Meinhard, H., Mitsou, V., Mornacchi, G., Myers, D., Nessi, M., Nicquevert, B., Niinikoski, T., Onions, C., Pailler, P., Passardi, G., Petersen, J., Placci, A., Poppleton, A., Posch, C., Poulard, G., Price, M., Riedler, P., Roe, S., Rohrbach, F., Rudge, A., Schmid, P., Schuler, G., Schwick, C., Shears, T., Simion, S., Soulhat, J., Spiwoks, R., Stavrianakou, M., Stavropoulos, G., Szeless, B., Tapprogge, S., Tartarelli, G.F., Ten Kate, H., Teterin, V., Tischhauser, H., Treichel, M., Tremblet, L., Tuura, L., Turala, M., Unel, G., Van der Bij, H., Vincke, H., von Boehn-Bucholz, R., Voss, R., Vreeswijk, M., Vuillemin, V., Weilhammer, P., Werner, P., Witzeling, W., Wotschack, J., Chen, C., Chen, T-Y., Cheng, S., Feng, C., Fu, Y., Kong, F., Li, H., Liu, T., Lu, W.D., Ma, J.M., Meng, X., Ouyang, Q., Qi, M., Tong, G.L., Wang, C., Xie, Y.G., Xue, L., Xu, G.F., Yang, B., Yang, T., Ye, B., Yu, X.Q., Zhang, B., Zhang, N., Zhang, Q.J., Zhao, J., Jinan, Bohm, J., Hakl, F., Hrivnac, J., Jirina, M., Lednicky, R., Lokajicek, M., Mares, J.J., Nemecek, S., Rizek, S., Sicho, P., Simak, V., Stastny, J., Stedron, M., Vanickova, M., Vrba, V., Weichert, J., Zitek, K., Davidek, T., Dolejsi, J., Dolezal, Z., Kucera, M., Leitner, R., Soustruznik, K., Suk, M., Tas, P., Trka, Z., Valkar, S., Wilhelm, I., Zdrazil, M., Jakubek, J., Kubasta, J., Ota, J., Pospisil, S., Sinor, M., Sodomka, J., Sopko, B., Stekl, I., Tomiak, Z., Dam, M., Hansen, J.D., Hansen, J.R., Hansen, P., Aubert, B., Beaugiraud, B., Billat, C., Boniface, J., Cailles, M., Chollet-LeFlour, F., Colas, J., Duchesneau, A., Dumont-Dayot, N., Girard, C., Gouanere, M., Jezequel, S., Kambara, H., Lafaye, R., Lesueur, J., Masserot, A., Massol, N., Moynot, M., Perrodo, P., Perrot, G., Prast, J., Riccadonna, X., Sauvage, G., Thion, J., Wingerter-Seez, I., Zitoun, R., Zolnierowski, Y., Biscarat, C., Chadelas, R., Crouau, M., Daudon, F., Grenier, P., Guicheney, Ch., Hebrard, C., Lefevre, R., Montarou, G., Pallin, D., Podlyski, F., Reinmuth, G., Santoni, C., Says, L.P., Vazeille, F., Andrieux, M.L., Collot, J., Dzahini, D., Ferrari, A., Hostachy, J.Y., Martin, Ph., Pouxe, J., Rabier, C., Rey-Campagnolle, M., De Saintignon, P., Stassi, P., Bee, C., Blanquart, L., Breugnon, P., Calvet, D., Clemens, J-C., Delpierre, P., Dinkespiler, B., Djama, F., Duval, P-Y., Etienne, F., Fede, E., Hallewell, G., Henry-Couannier, F., Hinz, L., Karst, P., Laugier, D., Le Van Suu, A., Martin, L., Martin, O., Meessen, C., Mirea, A., Monnier, E., Mouthuy, T., Nacasch, R., Nagy, E., Negroni, S., Nicod, D., Olivier, C., Pralavorio, P., Quian, Z., Repetti, B., Rondot, C., Rousseau, D., Rozanov, A., Sauvage, D., Tisserant, S., Touchard, F., Vacavant, L., Valin, I., Vigeolas, E., Wielers, M., Arnault, C., Auge, E., Barrand, G., Belot, G., Beney, J.L., Blaquiere, M., Bonivento, W., Bourdarios, C., Breton, D., Chollet, C., Coulon, J-P., Cros, Ph., De la Taille, C., Delebecque, P., Falleau, I., Fallou, A., Fournier, D., Grivaz, J-F., Imbert, P., Jacquier, Y., Mace, G., Martin-Chassard, G., Mencik, M., Merkel, B., Noppe, J-M., Parrour, G., Perus, A., Petroff, P., Puzo, P., Richer, J-P., Schaffer, A-C., Seguin-Moreau, N., Serin, L., Tocut, V., Vales, F., Veillet, J-J., Vernay, E., Zerwas, D., Astesan, F., Bertoli, W., Canton, B., David, J., Fichet, S., Fleuret, F., Imbault, D., Lacour, D., Laforge, B., Le Dortz, O., Martin, D., Poggioli, L., Rossel, F., Schwemling, P., Amadon, A., Bauer, F., Belorgey, J., Berriaud, C., Berthier, R., Borgeaud, P., Bystricky, J., Cacaut, D., Chalifour, M., Chevalier, L., Cloue, O., Dael, A., Delagnes, E., Desages, F., Durand, D., Ernwein, J., Gachelin, O., Gallet, B., Gastineau, B., de Girolamo, P., Guyot, C., Hansl-Kozanecka, T., Hubbard, J.R., Huet, M., Joudon, A., Juster, F.P., Kiourkos, S., Kozanecki, W., Laporte, J.F., Le Coreller, A., Le Du, P., Lesmond, C., Lugiez, F., Machefert, F., Mandjavidze, I., Mansoulie, B., Mayri, C., Molinie, F., Mur, M., Pabot, Y., Pascual, J., Perrin, P., Ponsot, P., Rey, J.M., Rouger, M., Schuller, J.P., Schune, Ph., Schwindling, J., Sun, Z., Taguet, J.P., Teiger, J., Thooris, B., Tirler, R., Van Hille, H., Virchaux, M., Chikovani, L., Chiladze, B., Djobava, T., Gabunia, L., Gogiberidze, G., Grigalashvili, T., Khelashvili, A., Khorguashvili, Z., Khubua, J., Kipiani, K., Koshtoev, V., Liparteliani, A., Metreveli, Z., Mosidze, M., Salukvadze, R., Sopromadze, D., Topchishvili, L., Ackers, M., Andre, F., Andreazza, A., Comes, G., Fischer, P., Geich-Gimbel, C., Klasen, V., Keil, M., Kobel, M., Kuhl, T., Meuser, S., Ockenfels, W., Stockmanns, T., Treis, J., Wermes, N., Geiser, A., Goessling, C., Huegging, F., Wuestenfeld, J., Wunstorf, R., Baer, Th., Chen, J., Ebling, D.G., Herten, G., Irsigler, R., Kollefrath, M., Landgraf, U., Lauxtermann, S., Ludwig, J., Mohr, W., Paschhoff, V., Rehmann, V., Rolker, B., Runge, K., Schaefer, F., Scherberger, G., Schmid, T., Webel, M., Weber, C., Geweniger, C., Hanke, P., Kluge, E.-E., Mahboubi, K., Meier, K., Pfeiffer, U., Putzer, A., Schumacher, C., Tittel, K., Wunsch, M., Fuchs, K., Geib, K.H., Jakobs, K., Kleinknecht, K., Koepke, L., Marschalkowski, E., Merle, K., Othegraven, R., Quast, G., Renk, B., Schaefer, U., Walkowiak, W., Zeitnitz, C., Kornmesser, K., Kugel, A., Lay, R., Ludvig, J., Maenner, R., Noffz, K-H., Ruehl, S., Sessler, M., Simmler, H., Singpiel, H., Chouridou, S., Deile, M., Kortner, O., Hessey, N.P., Schaile, D., Staude, A., Strohmer, R., Trefzger, T., Ackermann, K., Aderholz, M., Andricek, L., Blum, W., Bratzler, U., Brettel, H., Dietl, H., Dulny, B., Fent, J., Gruhn, C., Hauff, D., Koffeman, E., Kroha, H., Lutz, G., Manz, A., Moser, H.-G., Oberlack, H., Ostapchuk, A., Richter, R., Richter, R.H., Schacht, P., Schael, S., Soergel, V., Stenzel, H., Striegel, D., Tribanek, W., Holder, M., Schoefer, B., Ziolkowski, M., Becks, K.H., Braun, H., Drees, J., Gerlach, P., Glitza, K.W., Gregor, I.M., Hamacher, K., Kersten, S., Lenzen, G., Linder, C., Thadome, J., Wahlen, H., Dris, M., Filippas, A., Fokitis, E., Gazis, E.N., Katsoufis, E., Maltezos, S., Papadopoulou, T., Fasssouliotis, D., Giokaris, N., Ioannou, P., Kourkoumelis, C., Pancheluga, V., Petridis, A., Tatsis, S., Tzanakos, G.S., Vassiliou, M., Bouzakis, C., Chardalas, M., Dedoussis, S., Efstathiou, K., Lagouri, Th., Liolios, A., Paschalias, P., Petridou, C., Sampsonidis, D., Vichou, I., Zamani, M., Dado, S., Harel, A., Landesman, H., Lupu, N., Robins, S., Rozen, Y., Tarem, S., Abramowicz, H., Alexander, G., Bella, G., Benary, O., Dagan, S., Etzion, E., Grunhaus, J., Oren, Y., Breskin, A., Chechik, R., Duchovni, E., Eisenberg, Y., Gross, E., Hass, M., Karshon, U., Lellouch, D., Levinson, L., Mikenberg, G., Ayad, R., Capua, M., Lagatta, A., La Rotonda, L., Schioppa, M., Susinno, G., Valdata-Nappi, M., Bilokon, H., Cerutti, F., Chiarella, V., Curatolo, M., Dulach, B., Esposito, B., Ferrer, M.L., Maccarrone, G., Moccia, S., Pace, E., Pepe-Altarelli, M., Spitalieri, M., Zuffranieri, F., Barberis, D., Beccherle, R., Caso, C., Dameri, M., Darbo, G., Gagliardi, G., Gemme, C., Morettini, P., Musico, P., Olcese, M., Osculati, B., Parodi, F., Pozzo, A., Ridolfi, G., Rossi, L., Sette, G., Creti, P., Gorini, E., Grancagnolo, F., Palamara, O., Petrera, S., Primavera, M., Acerbi, E., Aleppo, M., Alessandria, F., Battistoni, G., Broggi, F., Caccia, M., Camin, D., Cavalli, D., Costa, G., Fanti, M., LaBanca, N., Lari, T., Mandelli, L., Mazzanti, M., Meroni, C., Perini, L., Ragusa, F., Resconi, S., Sala, P., Troncon, C., Vanini, S., Vegni, G., Volpini, G., Aloisio, A., Alviggi, M.G., Cevenini, F., Chiefari, G., De Asmundis, R., Merola, L., Napolitano, M., Patricelli, S., Cambiaghi, M., Conta, C., Ferrari, R., Fraternali, M., Lanza, A., Livan, M., Negri, A., Polesello, G., Rimoldi, A., Vercesi, V., Cavasinni, V., Cologna, S., Costanzo, D., Del Prete, T., Di Girolamo, B., Flaminio, V., Lami, S., Marrocchesi, P.S., Mazzoni, E., Paoletti, R., Renzoni, G., Roda, C., Spano, F., Suglia, R., Usai, G., Bagnaia, P., Bini, C., Caloi, R., Cardini, A., Cavallari, A., Ciapetti, G., De Zorzi, G., DiMattia, A., Falciano, S., Gauzzi, P., Gentile, S., Lacava, F., Luci, C., Luminari, L., Marzano, F., Mirabelli, G., Nisati, A., Petrolo, E., Pontecorvo, L., Veneziano, S., Zanello, L., Aielli, G., Baranov, S., Camarri, P., Cardarelli, R., Di Ciaccio, A., Liberti, B., Paoloni, A., Santonico, R., Bacci, C., Baroncelli, A., Ceradini, F., Farilla, A., Iodice, M., Orestano, D., Pastore, F., Spiriti, E., Stanescu, C., Cauz, D., D'Auria, S., De Angelis, A., Pauletta, G., Santi, L., Scuri, B., Waldner, F., del Papa, C., Tanaka, S., Asai, M., Iwata, Y., Ohsugi, T., Amako, K., Arai, Y., Fujii, H., Haruyama, T., Ikeno, M., Iwasaki, H., Kanzaki, J., Kohriki, T., Kondo, T., Manabe, A., Morita, Y., Nomachi, M., Ohska, T.K., Sasaki, O., Sasaki, T., Terada, S., Unno, Y., Watase, Y., Yamamoto, A., Yasu, Y., Kawagoe, K., Kurashige, H., Nozaki, M., Takeda, H., Sakamoto, H., Sasao, N., Takashima, R., Nagasaka, Y., Tanaka, Y., Nagamatsu, M., Yoshida, H., Takeshita, T., Hasegawa, Y., Homma, K., Imori, M., Kawamoto, T., Kobayashi, T., Fukunaga, C., Hamatsu, R., Emura, T., Chakir, H., Cherkaoui, R., Goujdami, D., El Kacimi, M., Hoummada, A., Saidi, H., Sayouty, E., Bobbink, G.J., Bos, K., Boterenbrood, H., Buis, E.J., Dankers, R.J., Daum, C., Groenstege, H., Hartjes, F., Hendriks, P., Heubers, W., Kaan, B., Kieft, G.N.M., Kluit, P., Kluit, R., Massaro, G.G.G., Meddeler, G., Peeters, S., Reichold, A., Rewiersma, P.A.M., Schuijlenburg, H., Spelt, J., Vermeulen, J.C., Werneke, P., Woudstra, M., van Eijk, B., van der Graaf, H., Brouwer, C., Crijns, F.J.G.H., Dijkema, J.A., De Jong, S.J., Kittel, W., Klok, P.F., Lavrijsen, W.T.L.P., Koenig, A.C., Metzger, W.J., Pols, G.-J., Schotanus, D.J., Wijnen, Th.A.M., Eigen, G., Frodesen, A.G., Klovning, A., Stugu, B., Bugge, L., Buran, T., Dorholt, O., Kristiansen, H., Madsen, R.A., Marshal, A., Midttun, G., Read, A.L., Rohne, O.M., Stapnes, S., Strandlie, A., Sundal, B., Blocki, J., Bocian, D., Gadomski, S., Gornicki, E., Godlewski, J., Hajduk, Z., Iwanski, W., Kaczmarska, A., Kisielewski, B., Korcyl, K., Madeyski, B., Malecki, P., Moszczynski, A., Olszowska, J., Piotrzkowski, K., Richter-Was, E., Sapinski, M., Wolter, M., Dabrowski, W., Grybos, P., Idzik, M., Jagielski, S., Jelen, K., Kiesilewska, D., Koperny, S., Kowalski, T., Rulikowska-Zarebska, E., Amaral, P., Amorim, A., Carvalho, J., Casarejos, E., David, M., Gomes, A., Gomes, J., Ivaniouchenkov, I., Maio, A., Maneira, M., Martins, J.P., Onofre, A., Pinhao, J., Santos, J., Silva, J., Varanda, M., Wolters, H., Portuguesa U., Figueira da Foz & Nova U., Lisboa, Alexa, C., Arsenescu, R., Badescu, E., Boldea, V., Caprini, I., Caprini, M., Constantin, F., Constantinescu, S., Dita, P., Dita, S., Micu, A., Micu, L., Niculescu, M., Pantea, D., Radu, A., Artamonov, A., Epchtein, V., Gorbunov, P., Gurin, R., Jemanov, V., Khovansky, V., Koutchenkov, A., Kruchinin, S., Maslennikov, A., Ryabinin, M., Shatalov, P., Tsoukerman, I., Zaitsev, V., Zeldovich, S., Akimov, A., Belov, M., Blagov, M., Fedorchuk, R., Gavrilenko, I., Kaioumov, F., Komar, A., Konovalov, S., Kopytine, M., Mouraviev, S., Popov, L., Shikanyan, A., Shmeleva, A., Snesarev, A., Speransky, M., Sulin, V., Tikhomirov, V., Vassilieva, L., Yakimenko, M., Bondarenko, V., Dolgoshein, B., Konstantinov, A., Romaniouk, A., Semenov, S., Smirnov, S., Sosnovtzev, V., Bashindjagian, G.L., Basiladze, S.G., Berejnoi, A., Erasov, A.B., Grishkevich, Y., Karmanov, D.E., Kramarenko, V.A., Larichev, A.N., Melikhov, D.I., Merkin, M.M., Nikitin, N.V., Rizatdinova, F.K., Selikov, A.V., Sivoklokov, S.Yu., Smirnova, L.N., Zverev, E.G., Batrakov, A., Chekhtman, A., Fedotov, M., Gaponenko, I., Klimenko, S., Kollegov, M., Kozlov, V., Kuper, E., Merzlyakov, Y., Panin, V., Shamov, A., Telnov, V., Tikhonov, Y., Velikzhanin, Y., Amelin, D.V., Ammosov, V.V., Antipov, Yu.M., Batarin, V., Bogoliubsky, M.Yu., Borissov, A.A., Borissov, E., Bozko, N.I., Bryzgalov, V.V., Chekulaev, S.V., Denisov, S.P., Dushkin, A.Yu., Fakhroutdinov, R., Fenyuk, A.B., Gapienko, V.A., Gilitsky, Yu.V., Goryatchev, V., Gouz, Yu.P., Karyukhin, A.N., Khokhlov, Yu.A., Kirsanov, M.M., Kiryunin, A.E., Klyukhin, V., Kojine, A., Kononov, A.I., Konstantinov, V., Kopikov, S.V., Korotkov, V.A., Kostrikov, M.E., Kostyukhin, V.V., Kravtsov, V.I., Kulemzin, A., Kurchaninov, L.L., Lapin, V.V., Levitsky, M.L., Los, S., Maximov, V., Miagkov, A.G., Mikhailin, V.N., Minaenko, A.A., Moiseev, A.M., Onuchin, V.A., Pleskach, A.V., Salomatin, Yu.I., Senko, V.A., Shein, I., Soldatov, A.P., Solodkov, A.A., Solovianov, O.V., Starchenko, E.A., Sviridov, Yu., Sytnik, V.V., Tchmil, V., Tchountonov, A., Tikhonov, V.V., Tsyupa, Yu., Usenko, E., Vorobiev, A.P., Vovenko, A.S., Zaets, V.G., Zaitsev, A.M., Zimin, S., Zmouchhko, V., Fedin, O., Filimonov, V., Gavrilov, G., Ivochkin, V., Khomoutnikov, V., Kolos, S., Krivchitch, A., Lochak, I., Maleev, V., Nadtochy, A., Patritchev, S., Prokofiev, D., Riabov, J., Schegelsky, V., Soloviev, I., Spiridenkov, E., Zalite, A., Alexandrov, I., Alexeev, G., Alikov, B., Anosov, V., Astvatsaturov, A., Azhgirei, L., Backovic, S., Boyko, I., Budagov, J., Chelkov, G., Cheplakov, A., Chirikov-Zorin, I., Chlachidze, G., Dedovich, D., Dodonov, V., Evtukhovich, P., Fedorov, A., Feshenko, A., Flyagin, V., Glagolev, V., Golikov, V., Golubykh, S., Gongadze, A., Gornushkin, Y., Gostkin, M., Iamburenko, V., Ignatenko, M., Juravlev, N., Kakurin, S., Kallinikov, V., Kalinichenko, V., Kazarinov, M., Kazymov, A., Kekelidze, G., Khasanov, A., Khomenko, B., Khovansky, N., Kotov, S., Kotov, V., Kovtun, V., Krumstein, Z., Kukhtin, V., Kuznetsov, O., Ladygin, E.U., Lazarev, A., Lebedev, A., Ljablin, M., Lomakin, Y., Malyshev, V., Malyukov, S., Manjavidze, D., Merekov, Y., Minashvili, I., Nikolenko, M., Nozdrin, A., Olshevski, A., Peshekhonov, V., Pisarev, I., Podkladkin, S., Pose, R., Potrap, I., Pukhov, O., Romanov, V., Rumyantsev, V., Russakovich, N., Ryabchenko, K., Salihagic, D., Savin, I., Scheltckov, A., Sedykh, Y., Semenov, A., Senchishin, V., Shabalin, D., Shalyugin, A., Shigaev, V., Shilov, S., Simic, M., Sissakian, A., Snyatkov, V., Sorokina, J., Tchepournov, V., Tkachev, L., Tokmenin, V., Topilin, N., Tskhadadze, E., Usov, Y., Vertogradov, L., Vinogradov, V., Vorozhtsov, S., Yarygin, G., Zhuravlev, V., Ban, J., Bruncko, D., Chochula, P., Chytracek, R., Dubnicka, S., Dubnickova, A., Ferencei, J., Garabik, R., Holik, P., Jusko, A., Kladiva, E., Kocper, B., Kubinec, P., Kurca, T., Luptak, M., Masarik, J., Povinec, P., Rosinsky, P., Stanicek, J., Stavina, P., Strizenec, P., Sykora, I., Tokar, S., Vanko, J., Cindro, V., Filipcic, A., Kramberger, G., Mandic, I., Mikuz, M., Tadel, M., Zontar, D., Blanch, O., Blanchot, G., Bosman, M., Cavalli-Sforza, M., Crespo, J.M., Dosil, M., Fernandez, E., Flix, J., Korolkov, I., Martinez, M., Miralles, Ll., Ostankov, A., Pacheco, A., Pena, J.C., Zamora, Y., Barreiro, F., Del Peso, J., Labarga, L., Ballester, F., Bernabeu, J., Camarena, F., Campabadal, F., Carrasco, R., Castillo, M.V., Costa, M.J., Ferrer, A., Fuster, J., Garcia, C., Gonzalez, V., Gonzalez de la Hoz, S., Higon, H., Lopez, J.M., Martinez, C., Modesto, P., Moreno, A., Lozano, M., Roldan, J., Romance, J.B., Ros, E., Salt, J., Sanchez, J., Sanchis, E., Santander, J., Ullan, M., Akesson, T., Almehed, S., Carling, H., Danielson, H., Eerola, P., Egede Anderson, U., Hedberg, V., Jarlskog, G., Korsmo, H., Lorstad, B., Lundberg, B., Mjornmark, U., Akerman, D., Carlson, P., Clement, C., Leven, S., Lund-Jensen, B., Pearce, M., Soderqvist, J., Vanyashin, A., Berglund, S., Bohm, C., Engstrom, M., Hellman, S., Holmgren, S-O., Johansson, E., Jon-And, K., Klereborn, J., Sellden, B., Silverstein, S., Sjolin, J., Yamdagni, N., Bingefors, N., Botner, O., Brenner, R., Bystrom, O., Coadou, Y., Damet, J., Ekelof, T., Gustafsson, L., Hallgren, A., Kullander, S., Staaf, P., Beck, H.P., Borer, K., Hess, M., Lehmann, G., Mommsen, R., Pretzl, K., Bonino, R., Clark, A.G., Couyoumtzelis, C., Demierre, Ph., Efthymiopoulos, I., Kowalewski, R., La Marra, D., Leger, A., Perrin, E., Vuandel, B., Wu, X., Atag, A., Cakir, O., Meric, N., Sultansoy, S., Turk, I., Ulvi Yilmazer, A., Arik, E., Celik, O., Cetin, S.A., Conka, T., Hacinliyan, A., Kurtulus, O., Mailov, A., Nurdan, K., Tanoren, B., Bright-Thomas, P., Charlton, D.G., Dowell, J.D., Garvey, J., Hillier, S.J., Homer, R.J., Jovanovic, P., Kenyon, I.R., McMahon, T.J., O'Neale, S.W., Staley, R.J., Watkins, P.M., Watson, A.T., Watson, N.K., Wilson, J.A., Batley, J.R., Carter, J.R., Drage, L., Goodrick, M.J., Hill, J.C., Munday, D.J., Parker, M.A., Robinson, D., Wyllie, K.H., Boyle, O., Candlin, D.J., Candlin, E.R.S., Knowles, I.G., Doyle, A.T., Flavell, A.J., Lynch, J.G., Martin, D.J., O'Shea, V., Raine, C., Saxon, D.H., Skillicorn, I.O., Smith, K.M., Brodbeck, T.J., Chilingarov, A., Henderson, R.C.W., Hughes, G., Jones, R.W.L., Ratoff, P.N., Sloan, T., Smizanska, M., Allport, P.P., Booth, P.S.L., Carroll, L.J., Cooke, P.A., Greenall, A., Houlden, M.A., Jackson, J.N., Jones, T.J., King, B.T., Maxfield, S.J., Moreton, A., Smith, N.A., Sutcliffe, P., Turner, P.R., Wells, D., Beck, G.A., Carter, A.A., Eisenhandler, E.F., Hughes, D.M., Kyberd, P., Landon, M., Lloyd, S.L., Newman-Coburn, D., Pentney, J.M., Pritchard, T.W., Thompson, G., Blair, G.A., George, S., Green, B.J., Medcalf, T., Strong, J.A., Anderson, B., Attree, D., Butterworth, J., Charalambous, A., Clarke, P., Cranfield, R., Crone, G., Fraser, J., Hayes, D., Hoare, T., Jones, T., Lane, J., Postranecky, M., Sherwood, P., Wheeler, S., Duerdoth, I.P., Dunne, P.W., Foster, J.M., Freestone, J., Hughes-Jones, R.E., Ibbotson, M., Kerr, A., Kolya, S.D., Loebinger, F.K., Marshall, R., Mercer, D., Pater, J., Snow, S., Thompson, R.J., Buira-Clarke, D., Cashmore, R., Coe, P., Hawes, B.M., Hill, J., Holmes, A., Howell, D., Huffman, B.T., Kundu, N., Loken, J.G., Mitra, A., Nickerson, R.B., Reichold, A.R., Renton, P.B., Segar, A.M., Wastie, R.L., Weidberg, A.R., Apsimon, R.J., Baines, J.T., Baynham, D.E., Botterill, D.R., Clifft, R.W., Edwards, M., English, R.L., Fisher, S.M., Gee, C.N.P., Gibson, M.D., Gillman, A.R., Greenfield, D., Hart, J.C., Hatley, R.W., Haywood, S.J., Hill, D.L., McCubbin, N.A., Middleton, R.P., Morrissey, M.C., Murray, W.J., Nichols, A., Norton, P.R., Payne, B.T., Perera, V.J.O., Phillips, P.W., Pilling, A., Saunders, B.J., Shah, T.P., Tappern, G.J., Tyndel, M., White, D.J., Wickens, F.J., Booth, C.N., Buttar, C.M., Combley, F.H., Dawson, I., Grigson, C., Lehto, M.H., Alam, S., Athar, B., Mahmood, A., Timm, S., Wappler, F., Zhichao, L., Berger, E.L., Blair, R., Dawson, J., Drake, G., Guarino, V., Hill, N., May, E.N., Nodulman, L.J., Price, L.E., Proudfoot, J., Schlereth, J.L., Stanek, R., Wagner, R.G., Wicklund, A.B., Yoshida, R., Cheu, E., Embry, T., Johns, K., Loch, P., Rutherfoord, J., Savine, A., Shaver, L., Shupe, M., Steinberg, J., Tompkins, D., De, K., Gallas, E., Li, J., Sosebee, M., Stephens, R., White, A., Barnett, M., Bintinger, D., Ciocio, A., Einsweiler, K., Gilchriese, M., Haber, C., Hinchliffe, I., Joshi, A., Loken, S., Marchesini, R., Milgrome, O., Niggli, H., Palaio, N., Richardson, J., Shapiro, M., Siegrist, J., Spieler, H., Trilling, G., Ahlen, S., Hazen, E., Shank, J., Simmons, E., Whitaker, J.S., Zhou, B., Behrends, S., Bensinger, J.R., Blocker, C., Hashemi, K., Kirsh, L.E., Wellenstein, H., Alforque, S., Barratt, R., Citterio, M., Gordeev, A., Gordon, H., Graf, N., Gratchev, V., Kandasamy, A., Koehler, J., Kotcher, J., Lissauer, D., Ma, H., Makowiecki, D., Murtagh, M.J., Norton, S., O'Connor, P., Paige, F., Polychronakos, V., Protopopescu, S., Radeka, V., Rahm, D.C., Rajagopalan, S., Rescia, S., Smith, G., Sondericker, J., Stephani, D., Stumer, I., Takai, H., Tcherniatine, V., Yu, B., Anderson, K., Bellerive, A., Blucher, E., Glenzinsky, D., Merritt, F., Oreglia, M., Pilcher, J., Pod, E., Sanders, H., Shochet, M., Tang, F., Teuscher, R., Wu, H., Cartiglia, N., Cunitz, H., Dodd, J., Gara, J., Leltchouk, M., Parsons, J., Seman, M., Shaevitz, M., Sippach, W., Willis, W., Zhang, L., Ebenstein, W.L., Goshaw, A.T., Lee, A.M., Oh, S.H., Robertson, W.J., Wang, C.H., Assamagan, K.A., Baker, O.K., McFarlane, W.K., Brandenburg, G., Feldman, G.J., Felt, N., Franklin, M.E.B., Huth, J., Oliver, J., Riegler, W., Callahan, J., Hanson, G., Luehring, F., Ogren, H., Rust, D.R., Fahlund, T., Hackett, C., Hall, R., Lankford, A.J., Pier, S., Schernau, M., Stoker, D., Haridas, P., Osborne, L.S., Paradiso, J.A., Pless, I.A., Taylor, F.E., Wadsworth, B.F., Ball, R., Campbell, M., Chapman, J.W., Diehl, E., Goldfarb, S., Hou, S., Kouba, D., Levin, D., McKee, S., Neal, H.A., Qian, J., Schick, H., Tarle, G., Thun, R., Weaverdyck, C., Abolins, M., Brock, R., Bromberg, C., Ermoline, Y., Huston, J., Linnemann, J., Miller, R., Pineiro, B., Pope, B.G., Richards, R., Weerts, H., Gold, M., Gorfine, G., Hoeferkamp, M., Seidel, S., Fortner, M., Sirotenko, V.I., Willis, S.E., Gan, K.K., Honscheid, K., Kagan, H., Kass, R., Boyd, R., Gutierrez, P., McMahon, T., Severini, H., Skubic, P., Snow, J., Strauss, M., Dressnandt, N., Keener, P., Newcomer, F.M., Van Berg, R., Williams, H.H., Cleland, W.E., Mcdonald, J.E., Paolone, V., Rabel, J., Zuk, G., England, D., Haelen, T., Slattery, P., Dorfan, D., Dubbs, T., Grillo, A., Heusch, C., Kashigin, S., Litke, A., Sadrozinski, H., Seiden, A., Spencer, E., Webster, A., Chou, T.-M., Evans, G., Stroynowski, R., Ye, J., Engelmann, R., Grannis, P., Hobbs, J., Jung, C.K., McCarthy, B., Rijssenbeek, M., Schamberger, D., Yanagisawa, C., Mann, A., Milburn, R., Napier, A., Sliwa, K., Errede, D., Errede, S., Haney, M.J., Thaler, J., Burnett, T.H., Cook, V., Daly, C., Davisson, R., Forbush, D., Guldenmann, H., Lubatti, H.J., Mockett, P.M., Rothberg, J., Zhao, T., Fasching, D., Gonzalez, S., Jared, R.C., Pan, Y.B., Scott, I.J., Wu, S.L., Yamartino, J.M., and Zobernig, G.

Subjects
Detectors and Experimental Techniques
Published
1999

27. Hadronic Shower Development in Iron-Scintillator Tile Calorimetry

Author

Amaral, P, Amorim, A, Anderson, K, Barreira, G, Benetta, R, Berglund, S, Biscarat, C, Blanchot, G, Blucher, E, Bogush, A, Bohm, C, Boldea, V, Borisov, O, Bosman, M, Bromberg, C, Budagov, J, Burdin, S, Caloba, L, Carvalho, J, Casado, P, Castillo, MV, Cavalli-Sforza, M, Cavasinni, V, Chadelas, R, Chirikov-Zorin, I, Chlachidze, G, Cobal, M, Cogswell, F, Colaco, F, Cologna, S, Constantinescu, S, Costanzo, D, Crouau, M, Daudon, F, David, J, David, M, Davidek, T, Dawson, J, De, K, Del Prete, T, De Santo, A, Di Girolamo, B, Dita, S, Dolejsi, J, Dolezal, Z, Downing, R, Efthymiopoulos, I, Engstrom, M, Errede, D, Errede, S, Evans, H, Fenyuk, A, Ferrer, A, Flaminio, V, Gallas, E, Gaspar, M, Gil, I, Gildemeister, O, Glagolev, V, Gomes, A, Gonzalez, V, De la Hoz, SG, Grabski, V, Grauges, E, Grenier, P, Hakopian, H, Haney, M, Hansen, M, Hellman, S, Henriques, A, Hebrard, C, Higon, E, Holmgren, S, Huston, J, Ivanyushenkov, Y, Jon-And, K, Juste, A, Kakurin, S, Karapetian, G, Karyukhin, A, Kopikov, S, Kukhtin, V, Kulchitsky, Y, Kurzbauer, W, Kuzmin, M, Lami, S, Lapin, V, Lazzeroni, C, Lebedev, A, Leitner, R, Li, J, Lomakin, Y, Lomakina, O, Lokajicek, M, Amengual, JML, Maio, A, Malyukov, S, Marroquin, F, Martins, JP, Mazzoni, E, Merritt, F, Miller, R, Minashvili, I, Miralles, L, Montarou, G, Munar, A, Nemecek, S, Nessi, M, Onofre, A, Orteu, S, Park, IC, Pallin, D, Pantea, D, Paoletti, R, Patriarca, J, Pereira, A, Perlas, JA, Petit, P, Pilcher, J, Pinhao, J, Poggioli, L, Price, L, Proudfoot, J, Pukhov, O, Reinmuth, G, Renzoni, G, Richards, R, Roda, C, Romance, JB, Romanov, V, Ronceux, B, Rosnet, P, Rumyantsev, V, Russakovich, N, Sanchis, E, Sanders, H, Santoni, C, Santos, J, Sawyer, L, Says, LP, Seixas, JM, Sellden, B, Semenov, A, Shchelchkov, A, Shochet, M, Simaitis, V, Sissakian, A, Solodkov, A, Solovianov, O, Sonderegger, P, Sosebee, M, Soustruznik, K, Spano, F, Stanek, R, Starchenko, E, Stephens, R, Suk, M, Tang, F, Tas, P, Thaler, J, Tokar, S, Topilin, N, Trka, Z, Turcot, A, Turcotte, M, Valkar, S, Varandas, MJ, Vartapetian, A, Vazeille, F, Vichou, I, Vinogradov, V, Vorozhtsov, S, Wagner, D, White, A, Wolters, H, Yamdagni, N, Yarygin, G, Yosef, C, Zaitsev, A, Zdrazil, M, Zuniga, J, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and ATLAS

Subjects
Nuclear and High Energy Physics, Particle physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Calorimetry, Scintillator, 01 natural sciences, Particle detector, Partícules (Física nuclear), High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, Computer data analysis, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, Nuclear Experiment, Instrumentation, Physics, 010308 nuclear & particles physics, PROFILES, Calorimeter, Transverse plane, visual_art, Scintillation counter, visual_art.visual_art_medium, Measuring instrument, Física nuclear, High Energy Physics::Experiment, Tile
Abstract

The lateral and longitudinal profiles of hadronic showers detected by a prototype of the ATLAS Iron-Scintillator Tile Hadron Calorimeter have been investigated. This calorimeter uses a unique longitudinal configuration of scintillator tiles. Using a fine-grained pion beam scan at 100 GeV, a detailed picture of transverse shower behavior is obtained. The underlying radial energy densities for four depth segments and for the entire calorimeter have been reconstructed. A three-dimensional hadronic shower parametrization has been developed. The results presented here are useful for understanding the performance of iron-scintillator calorimeters, for developing fast simulations of hadronic showers, for many calorimetry problems requiring the integration of a shower energy deposition in a volume and for future calorimeter design., Comment: 36 pages, 20 firures. Submitted to NIM A

Published
1999
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28. Results from a combined test of an electromagnetic liquid argon calorimeter with a hadronic scintillating-tile calorimeter

Author

Ajaltouni, Z, Albiol, F, Alifanov, A, Amaral, P, Ambrosini, G, Amorim, A, Anderson, K, Astvatsaturov, A, Aubert, B, Auge, E, Autiero, D, Azuelos, G, Badaud, F, Baisin, L, Battistoni, G, Bazan, A, Bee, C, Bellettini, G, Berglund, S, Berset, JC, Blaj, C, Blanchot, G, Blucher, E, Bogush, A, Bohm, C, Boldea, V, Borisov, O, Bosman, M, Bouhemaid, N, Brette, P, Bromberg, C, Brossard, M, Budagov, J, Buono, S, Caloba, L, Camin, DV, Canton, B, Casado, P, Cavalli, D, CavalliSforza, M, Cavasinni, V, Chadelas, R, Chase, R, Chekhtman, A, Chevaleyre, JC, Chevalley, JL, ChirikovZorin, I, Chlachidze, G, Chollet, JC, Cobal, M, Cogswell, F, Colas, J, Collot, J, Cologna, S, Constantinescu, S, Costa, G, Costanzo, D, Cozzi, L, Crouau, M, Dargent, P, Daudon, F, David, M, Davidek, T, Dawson, J, De, K, delaTaille, C, DelPrete, T, Depommier, P, deSaintignon, P, DeSanto, A, Dinkespiller, B, DiGirolamo, B, Dita, S, Dolejsi, J, Dolezal, Z, Downing, R, Dugne, JJ, Duval, PY, Dzahini, D, Efthymiopoulos, I, Errede, D, Errede, S, Etienne, F, Evans, H, Fassnacht, P, Fedyakin, N, Ferrari, A, Ferreira, P, Ferrer, A, Flaminio, V, Fouchez, D, Fournier, D, Fumagalli, G, Gallas, E, Gaspar, M, Gianotti, F, Gildemeister, O, Gingrich, DM, Glagolev, V, Golubev, V, Gomes, A, Gonzalez, J, Gordon, HA, Grabsky, V, Hakopian, H, Haney, M, Hellman, S, Henriques, A, Holmgren, S, Honore, PF, Hostachy, JY, Huston, J, Ivanyushenkov, Y, Jezequel, S, Johansson, E, JonAnd, K, Jones, R, Juste, A, Kakurin, S, Karapetian, G, Karyukhin, A, Khokhlov, Y, Klyukhin, V, Kolomoets, V, Kopikov, S, Kostrikov, M, Kovtun, V, Kukhtin, V, Kulagin, M, Kulchitsky, Y, Laborie, G, Lami, S, Lapin, V, Lebedev, A, Lefebvre, M, Leflour, T, Leitner, R, LeonFlorian, E, Leroy, C, LeVanSuu, A, Li, J, Liba, I, Linossier, O, Lokajicek, M, Lomakin, Y, Lomakina, O, LundJensen, B, Mahout, G, Maio, A, Malyukov, S, Mandelli, L, Mansoulie, B, Mapelli, L, Marin, CP, Marroquin, F, Martin, L, Mazzanti, M, Mazzoni, E, Merritt, F, Michel, B, Miller, R, Minashvili, I, Miotto, A, Miralles, L, Mnatsakanian, E, Monnier, E, Montarou, G, Mornacchi, G, Muanza, GS, Nagy, E, Nemecek, S, Nessi, M, Nicoleau, S, Noppe, JM, Olivetto, C, Orteu, S, Padilla, C, Pallin, D, Pantea, D, Parrour, G, Pereira, A, Perini, L, Perlas, JA, Petroff, P, Pilcher, J, Pinfold, JL, PlothowBesch, H, Poggioli, L, Poirot, S, Polesello, G, Price, L, Protopopov, Y, Proudfoot, J, Pukhov, O, Radeka, V, Rahm, D, Reinmuth, G, Renardy, JF, Renzoni, G, Resconi, S, Richards, R, Riu, I, Romanov, V, Ronceux, B, Rumyantsev, V, Russakovich, N, Sala, P, Sanders, H, Sauvage, G, Savard, P, SavoyNavarro, A, Sawyer, L, Says, LP, Schaffer, A, Scheel, C, Schwemling, P, Schwindling, J, SeguinMoreau, N, Seixas, JM, Sellden, B, Seman, M, Semenov, A, Senchishin, V, Serin, L, Shchelchkov, A, Shevtsov, V, Shochet, M, Sidorov, V, Simaitis, V, Simion, S, Sissakian, A, Solodkov, A, Sonderegger, P, Soustruznik, K, Stanek, R, Starchenko, E, Stephani, D, Stephens, R, Studenov, S, Suk, M, Surkov, A, Tang, F, Tardell, S, Tas, P, Teiger, J, Teubert, F, Thaler, J, Tisserand, V, Tisserant, S, Tokar, S, Topilin, N, Trka, Z, Turcot, A, Turcotte, M, Valkar, S, Vartapetian, A, Vazeille, F, Vichou, I, Vinogradov, V, Vorozhtsov, S, Vuillemin, V, Wagner, D, White, A, WingerterSeez, I, Yamdagni, N, Yarygin, G, Yosef, C, Zaitsev, A, Zdrazil, M, Zitoun, R, Zolnierowski, YP, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), ATLAS, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, 0103 physical sciences, High Energy Physics::Experiment, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, Nuclear Experiment, 010306 general physics, 01 natural sciences, Instrumentation
Abstract

The first combined test of an electromagnetic liquid argon accordion calorimeter and a hadronic scintillating-tile calorimeter was carried out at the CERN SPS. These devices are prototypes of the barrel calorimeter of the future ATLAS experiment at the LHC. The energy resolution of pions in the energy range from 20 to 300~GeV at an incident angle $\theta$ of about 11$^\circ$ is well-described by the expression $\sigma/E = ((46.5 \pm 6.0)\%/\sqrt{E} +(1.2 \pm 0.3)\%) \oplus (3.2 \pm 0.4)~\mbox{GeV}/E$. Shower profiles, shower leakage, and the angular resolution of hadronic showers were also studied.

Published
1997
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29. A precise measurement of 180 GeV muon energy losses in iron

Author

Amaral, P., Antonio Amorim, Anderson, K., Artikov, A., Benetta, R., Berglund, S., Biscarat, C., Blanch, O., Blanchot, G., Bogush, A., Bohm, C., Boldea, V., Borisov, O., Bosman, M., Bromberg, C., Bravo, S., Budagov, J., Burdin, S., Caloba, L., Camarena, F., Carvalho, J., Castillo, M. V., Cavalli-Sforza, M., Cavasinni, V., Cerqueira, A. S., Chadelas, R., Chirikov-Zorin, I., Chlachidze, G., Cobal, M., Cogswell, F., Cologna, S., Constantinescu, S., Costanzo, D., Cowan, B., Crouau, M., Daudon, F., David, M., Davidek, T., Dawson, J., De, K., Delfino, M., Del Prete, T., Santo, A., Di Girolamo, B., Dita, S., Downing, R., Engström, M., Errede, D., Errede, S., Fassi, F., Fenyuk, A., Ferrer, A., Flaminio, V., Flix, J., Garabik, R., Gil, I., Gildemeister, O., Glagolev, V., Gomes, A., Gonzalez, V., González La Hoz, S., Grabski, V., Grenier, P., Hakopian, H., Haney, M., Hellman, S., Henriques, A., Hebrard, C., Higon, E., Holik, P., Holmgren, S., Hruska, I., Huston, J., Jon-And, K., Kakurin, S., Karyukhin, A., Khubua, J., Kopikov, S., Krivkova, P., Kukhtin, V., Kulchitsky, Y., Kuzmin, M., Lami, S., Lapin, V., Lazzeroni, C., Lebedev, A., Leitner, R., Li, J., Lomakin, Y., Lomakina, O., Lokajicek, M., Lopez Amengual, J. M., Maio, A., Malyukov, S., Marroquin, F., Mataix, L., Mazzoni, E., Merritt, F., Miller, R., Minashvili, I., Miralles, L., Montarou, G., Nemecek, S., Nessi, M., Onofre, A., Ostankov, A., Pacheco, A., Pallin, D., Pantea, D., Paoletti, R., Park, I. C., Pilcher, J., Pinhão, J., Price, L., Proudfoot, J., Pukhov, O., Reinmuth, G., Renzoni, G., Richards, R., Roda, C., Roldan, J., Romance, J. B., Romanov, V., Rosnet, P., Ruiz, H., Russakovich, N., Sanchis, E., Sanders, H., Santoni, C., Santos, J., Says, L. -P, Seixas, J. M., Selldèn, B., Semenov, A., Shchelchkov, A., Shochet, M., Silva, J., Simaitis, V., Sissakian, A., Solodkov, A., Solovianov, O., Sosebee, M., Soustruznik, K., Spanó, F., Stanek, R., Starchenko, E., Stavina, P., Suk, M., Sykora, I., Tang, F., Tas, P., Thaler, J., Thome-Filho, Z. D., Tokar, S., Topilin, N., Valkar, S., Varanda, M. J., Vartapetian, A., Vazeille, F., Vichou, I., Vinogradov, V., Vorozhtsov, S., White, A., Wolters, H., Yamdagni, N., Yarygin, G., Yosef, C., and Zaitsev, A.

Subjects
Physics, BREMSSTRAHLUNG, Muon, Large Hadron Collider, Physics and Astronomy (miscellaneous), PAIR PRODUCTION, Hadron, Bremsstrahlung, Form factor (quantum field theory), Electron, Radiation length, CALORIMETER, Nuclear physics, Pair production, High Energy Physics::Experiment, Atomic physics, Nuclear Experiment, Engineering (miscellaneous)
Abstract

The energy loss spectrum of 180 GeV muons has been measured with the 5.6 m long finely segmented Module 0 of the ATLAS hadron tile calorimeter at the CERN SPS. The differential probability dP/d nu per radiation length of a fractional energy loss nu = Delta E/sub mu //E /sub mu / has been measured in the range 0.025 or= nu or=0.97; it is compared with theoretical predictions for energy losses due to bremsstrahlung, production of electron-positron pairs, and energetic knock-on electrons. The iron elastic form factor correction Delta /sub Fe//sup el/=1.63+or-0.17/sub stat/+or-023/sub syst$/ -/sub 0.14 //sup +0.20//sub theor/ to muon bremsstrahlung in the region of no screening of the nucleus by atomic electrons has been measured for the first time, and is compared with different theoretical predictions. (31 refs).

30. CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Author

Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., Evdoshenko E., Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., and Evdoshenko E.

Abstract

© 2016 The Author(s)Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental autoimmune encephalomyelitis in dark Agouti rats. The objective of this study was to assess the safety of Xemys in the treatment of patients with relapsing-remitting multiple sclerosis (MS) and secondary progressive MS, who failed to achieve a sustained response to first-line disease-modifying therapies. In this phase I, open-label, dose-escalating, proof-of-concept study, 20 patients with relapsing-remitting or secondary progressive MS received weekly subcutaneously injections with ascending doses of Xemys up to a total dose of 2.675 mg. Clinical examinations, including Expanded Disability Status Scale score, magnetic resonance imaging results, and serum cytokine concentrations, were assessed before the first injection and for up to 17 weeks after the final injection. Xemys was safe and well tolerated when administered for 6 weeks to a maximum single dose of 900 μg. Expanded Disability Status Scale scores and numbers of T2-weighted and new gadolinium-enhancing lesions on magnetic resonance imaging were statistically unchanged at study exit compared with baseline; nonetheless, the increase of number of active gadolinium-enhancing lesions on weeks 7 and 10 in comparison with baseline was statistically significant. During treatment, the serum concentrations of the cytokines monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and interleukin-7 decreased, whereas the level of tumor necrosis factor-α increased. These results provide evidence for the further development of Xemys as an antigen-specific, disease-modifying therapy for patients with MS.

31. CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Author

Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., Evdoshenko E., Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., and Evdoshenko E.

Abstract

© 2016, The Author(s).Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental autoimmune encephalomyelitis in dark Agouti rats. The objective of this study was to assess the safety of Xemys in the treatment of patients with relapsing-remitting multiple sclerosis (MS) and secondary progressive MS, who failed to achieve a sustained response to first-line disease-modifying therapies. In this phase I, open-label, dose-escalating, proof-of-concept study, 20 patients with relapsing-remitting or secondary progressive MS received weekly subcutaneously injections with ascending doses of Xemys up to a total dose of 2.675 mg. Clinical examinations, including Expanded Disability Status Scale score, magnetic resonance imaging results, and serum cytokine concentrations, were assessed before the first injection and for up to 17 weeks after the final injection. Xemys was safe and well tolerated when administered for 6 weeks to a maximum single dose of 900 μg. Expanded Disability Status Scale scores and numbers of T2-weighted and new gadolinium-enhancing lesions on magnetic resonance imaging were statistically unchanged at study exit compared with baseline; nonetheless, the increase of number of active gadolinium-enhancing lesions on weeks 7 and 10 in comparison with baseline was statistically significant. During treatment, the serum concentrations of the cytokines monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and interleukin-7 decreased, whereas the level of tumor necrosis factor-α increased. These results provide evidence for the further development of Xemys as an antigen-specific, disease-modifying therapy for patients with MS.

32. Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF- α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients

Author

Lomakin Y., Belogurov A., Glagoleva I., Stepanov A., Zakharov K., Okunola J., Smirnov I., Genkin D., Gabibov A., Lomakin Y., Belogurov A., Glagoleva I., Stepanov A., Zakharov K., Okunola J., Smirnov I., Genkin D., and Gabibov A.

Abstract

© 2016 Yakov Lomakin et al.We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys administration in MS patients. We observed a statistically significant decrease of MCP-1/CCL2, MIP-1β/CCL4, IL-7, and IL-2 at the time of study completion. In contrast, the serum levels of TNF-α were remarkably elevated. Our data suggest that the administration of Xemys leads to a normalization of cytokine status in MS patients to values commonly reported for healthy subjects. These data are an important contribution for the upcoming Xemys clinical trials.

33. Mediators and biomarkers of inflammation in meningitis: Cytokine and peptidome profiling of cerebrospinal fluid

Author

Belogurov A., Ivanova O., Lomakin Y., Ziganshin R., Vaskina M., Knorre V., Klimova E., Gabibov A., Ivanov V., Govorun V., Belogurov A., Ivanova O., Lomakin Y., Ziganshin R., Vaskina M., Knorre V., Klimova E., Gabibov A., Ivanov V., and Govorun V.

Abstract

© 2016, Pleiades Publishing, Ltd.Differential diagnosis of bacterial and viral meningitis is an urgent problem of the modern clinical medicine. Early and accurate detection of meningitis etiology largely determines the strategy of its treatment and significantly increases the likelihood of a favorable outcome for the patient. In the present work, we analyzed the peptidome and cytokine profiles of cerebrospinal fluid (CSF) of 17 patients with meningitis of bacterial and viral etiology and of 20 neurologically healthy controls. In addition to the identified peptides (potential biomarkers), we found significant differences in the cytokine status of the CSF of the patients. We found that cut-off of 100 pg/ml of IL-1β, TNF, and GM-CSF levels discriminates bacterial and viral meningitis with 100% specificity and selectivity. We demonstrated for the first time the reduction in the level of two cytokines, IL-13 and GM-CSF, in the CSF of patients with viral meningitis in comparison with the controls. The decrease in GM-CSF level in the CSF of patients with viral meningitis can be explained by a disproportionate increase in the levels of cytokines IL-10, IFN-γ, and IL-4, which inhibit the GM-CSF expression, whereas IL-1, IL-6, and TNF activate it. These observations suggest an additional approach for differential diagnosis of bacterial and viral meningitis based on the normalized ratio IL-10/IL-1β and IL-10/TNF > 1, as well as on the ratio IFN-γ/IL-1β and IFN-γ/ TNF < 0.1. Our findings extend the panel of promising clinical and diagnostic biomarkers of viral and bacterial meningitis and reveal opposite changes in the cytokine expression in meningitis due to compensatory action of proand antiinflammatory factors.

34. Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity

Author

Belogurov A., Kuzina E., Kudriaeva A., Kononikhin A., Kovalchuk S., Surina Y., Smirnov I., Lomakin Y., Bacheva A., Stepanov A., Karpova Y., Lyupina Y., Kharybin O., Melamed D., Ponomarenko N., Sharova N., Nikolaev E., Gabibov A., Belogurov A., Kuzina E., Kudriaeva A., Kononikhin A., Kovalchuk S., Surina Y., Smirnov I., Lomakin Y., Bacheva A., Stepanov A., Karpova Y., Lyupina Y., Kharybin O., Melamed D., Ponomarenko N., Sharova N., Nikolaev E., and Gabibov A.

Abstract

© The Author(s). Recent findings indicate that the ubiquitin-proteasome system is involved in the pathogenesis of cancer as well as autoimmune and several neurodegenerative diseases, and is thus a target for novel therapeutics. One disease that is related to aberrant protein degradation is multiple sclerosis, an autoimmune disorder involving the processing and presentation of myelin autoantigens that leads to the destruction of axons. Here, we show that brainderived proteasomes from SJL mice with experimental autoimmune encephalomyelitis (EAE) in an ubiquitinindependent manner generate significantly increased amounts of myelin basic protein peptides that induces cytotoxic lymphocytes to target mature oligodendrocytes ex vivo. Ten times enhanced release of immunogenic peptides by cerebral proteasomes from EAE-SJL mice is caused by a dramatic shift in the balance between constitutive and β1ihigh immunoproteasomes in the CNS of SJL mice with EAE. We found that during EAE, β1i is increased in resident CNS cells, whereas β5i is imported by infiltrating lymphocytes through the blood-brain barrier. Peptidyl epoxyketone specifically inhibits brain-derived β1ihigh immunoproteasomes in vitro (kobs/[I] = 240 M-1s-1), and at a dose of 0.5 mg/kg, it ameliorates ongoing EAE in vivo. Therefore, our findings provide novel insights into myelin metabolism in pathophysiologic conditions and reveal that the β1i subunit of the immunoproteasome is a potential target to treat autoimmune neurologic diseases.

35. CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Author

Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., Evdoshenko E., Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., and Evdoshenko E.

Abstract

© 2016, The Author(s).Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental autoimmune encephalomyelitis in dark Agouti rats. The objective of this study was to assess the safety of Xemys in the treatment of patients with relapsing-remitting multiple sclerosis (MS) and secondary progressive MS, who failed to achieve a sustained response to first-line disease-modifying therapies. In this phase I, open-label, dose-escalating, proof-of-concept study, 20 patients with relapsing-remitting or secondary progressive MS received weekly subcutaneously injections with ascending doses of Xemys up to a total dose of 2.675 mg. Clinical examinations, including Expanded Disability Status Scale score, magnetic resonance imaging results, and serum cytokine concentrations, were assessed before the first injection and for up to 17 weeks after the final injection. Xemys was safe and well tolerated when administered for 6 weeks to a maximum single dose of 900 μg. Expanded Disability Status Scale scores and numbers of T2-weighted and new gadolinium-enhancing lesions on magnetic resonance imaging were statistically unchanged at study exit compared with baseline; nonetheless, the increase of number of active gadolinium-enhancing lesions on weeks 7 and 10 in comparison with baseline was statistically significant. During treatment, the serum concentrations of the cytokines monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and interleukin-7 decreased, whereas the level of tumor necrosis factor-α increased. These results provide evidence for the further development of Xemys as an antigen-specific, disease-modifying therapy for patients with MS.

36. Mediators and biomarkers of inflammation in meningitis: Cytokine and peptidome profiling of cerebrospinal fluid

Author

Belogurov A., Ivanova O., Lomakin Y., Ziganshin R., Vaskina M., Knorre V., Klimova E., Gabibov A., Ivanov V., Govorun V., Belogurov A., Ivanova O., Lomakin Y., Ziganshin R., Vaskina M., Knorre V., Klimova E., Gabibov A., Ivanov V., and Govorun V.

Abstract

© 2016, Pleiades Publishing, Ltd.Differential diagnosis of bacterial and viral meningitis is an urgent problem of the modern clinical medicine. Early and accurate detection of meningitis etiology largely determines the strategy of its treatment and significantly increases the likelihood of a favorable outcome for the patient. In the present work, we analyzed the peptidome and cytokine profiles of cerebrospinal fluid (CSF) of 17 patients with meningitis of bacterial and viral etiology and of 20 neurologically healthy controls. In addition to the identified peptides (potential biomarkers), we found significant differences in the cytokine status of the CSF of the patients. We found that cut-off of 100 pg/ml of IL-1β, TNF, and GM-CSF levels discriminates bacterial and viral meningitis with 100% specificity and selectivity. We demonstrated for the first time the reduction in the level of two cytokines, IL-13 and GM-CSF, in the CSF of patients with viral meningitis in comparison with the controls. The decrease in GM-CSF level in the CSF of patients with viral meningitis can be explained by a disproportionate increase in the levels of cytokines IL-10, IFN-γ, and IL-4, which inhibit the GM-CSF expression, whereas IL-1, IL-6, and TNF activate it. These observations suggest an additional approach for differential diagnosis of bacterial and viral meningitis based on the normalized ratio IL-10/IL-1β and IL-10/TNF > 1, as well as on the ratio IFN-γ/IL-1β and IFN-γ/ TNF < 0.1. Our findings extend the panel of promising clinical and diagnostic biomarkers of viral and bacterial meningitis and reveal opposite changes in the cytokine expression in meningitis due to compensatory action of proand antiinflammatory factors.

37. CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Author

Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., Evdoshenko E., Belogurov A., Zakharov K., Lomakin Y., Surkov K., Avtushenko S., Kruglyakov P., Smirnov I., Makshakov G., Lockshin C., Gregoriadis G., Genkin D., Gabibov A., and Evdoshenko E.

Abstract

© 2016 The Author(s)Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental autoimmune encephalomyelitis in dark Agouti rats. The objective of this study was to assess the safety of Xemys in the treatment of patients with relapsing-remitting multiple sclerosis (MS) and secondary progressive MS, who failed to achieve a sustained response to first-line disease-modifying therapies. In this phase I, open-label, dose-escalating, proof-of-concept study, 20 patients with relapsing-remitting or secondary progressive MS received weekly subcutaneously injections with ascending doses of Xemys up to a total dose of 2.675 mg. Clinical examinations, including Expanded Disability Status Scale score, magnetic resonance imaging results, and serum cytokine concentrations, were assessed before the first injection and for up to 17 weeks after the final injection. Xemys was safe and well tolerated when administered for 6 weeks to a maximum single dose of 900 μg. Expanded Disability Status Scale scores and numbers of T2-weighted and new gadolinium-enhancing lesions on magnetic resonance imaging were statistically unchanged at study exit compared with baseline; nonetheless, the increase of number of active gadolinium-enhancing lesions on weeks 7 and 10 in comparison with baseline was statistically significant. During treatment, the serum concentrations of the cytokines monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and interleukin-7 decreased, whereas the level of tumor necrosis factor-α increased. These results provide evidence for the further development of Xemys as an antigen-specific, disease-modifying therapy for patients with MS.

38. Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF- α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients

Author

Lomakin Y., Belogurov A., Glagoleva I., Stepanov A., Zakharov K., Okunola J., Smirnov I., Genkin D., Gabibov A., Lomakin Y., Belogurov A., Glagoleva I., Stepanov A., Zakharov K., Okunola J., Smirnov I., Genkin D., and Gabibov A.

Abstract

© 2016 Yakov Lomakin et al.We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys administration in MS patients. We observed a statistically significant decrease of MCP-1/CCL2, MIP-1β/CCL4, IL-7, and IL-2 at the time of study completion. In contrast, the serum levels of TNF-α were remarkably elevated. Our data suggest that the administration of Xemys leads to a normalization of cytokine status in MS patients to values commonly reported for healthy subjects. These data are an important contribution for the upcoming Xemys clinical trials.

39. Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity

Author

Belogurov A., Kuzina E., Kudriaeva A., Kononikhin A., Kovalchuk S., Surina Y., Smirnov I., Lomakin Y., Bacheva A., Stepanov A., Karpova Y., Lyupina Y., Kharybin O., Melamed D., Ponomarenko N., Sharova N., Nikolaev E., Gabibov A., Belogurov A., Kuzina E., Kudriaeva A., Kononikhin A., Kovalchuk S., Surina Y., Smirnov I., Lomakin Y., Bacheva A., Stepanov A., Karpova Y., Lyupina Y., Kharybin O., Melamed D., Ponomarenko N., Sharova N., Nikolaev E., and Gabibov A.

Abstract

© The Author(s). Recent findings indicate that the ubiquitin-proteasome system is involved in the pathogenesis of cancer as well as autoimmune and several neurodegenerative diseases, and is thus a target for novel therapeutics. One disease that is related to aberrant protein degradation is multiple sclerosis, an autoimmune disorder involving the processing and presentation of myelin autoantigens that leads to the destruction of axons. Here, we show that brainderived proteasomes from SJL mice with experimental autoimmune encephalomyelitis (EAE) in an ubiquitinindependent manner generate significantly increased amounts of myelin basic protein peptides that induces cytotoxic lymphocytes to target mature oligodendrocytes ex vivo. Ten times enhanced release of immunogenic peptides by cerebral proteasomes from EAE-SJL mice is caused by a dramatic shift in the balance between constitutive and β1ihigh immunoproteasomes in the CNS of SJL mice with EAE. We found that during EAE, β1i is increased in resident CNS cells, whereas β5i is imported by infiltrating lymphocytes through the blood-brain barrier. Peptidyl epoxyketone specifically inhibits brain-derived β1ihigh immunoproteasomes in vitro (kobs/[I] = 240 M-1s-1), and at a dose of 0.5 mg/kg, it ameliorates ongoing EAE in vivo. Therefore, our findings provide novel insights into myelin metabolism in pathophysiologic conditions and reveal that the β1i subunit of the immunoproteasome is a potential target to treat autoimmune neurologic diseases.

40. Probing surface membrane receptors using engineered bacteriophage bioconjugates

Author

Lomakin Y., Kaminskaya A., Stepanov A., Shmidt A., Gabibov A., Belogurov A., Lomakin Y., Kaminskaya A., Stepanov A., Shmidt A., Gabibov A., and Belogurov A.

Abstract

© 2019 American Chemical Society. Specific recognition of ligands by surface receptors of eukaryotic cells is a fundamental process in sensing of the exogenous environment, including cell-to-cell communication. These interactions are therefore widely probed in both basic studies and drug development to enhance or interrupt them. Here, we designed a high-throughput publicly available platform for visualization and selection of eukaryotic cells according to the specificity of surface-exposed receptors by consolidation of phage display and flow cytometry techniques. Polypeptide ligands for membrane receptors are incorporated into every copy of p3 protein of M13K07 bacteriophage, which is intracellularly biotinylated to further accept PE-Cy7-labled streptavidin. Transgenic antigen-specific B-cells expressing membrane-tethered lymphoid B-cell receptor in a single-chain format interacted with engineered bacteriophages exposing the polypeptide ligand with an unprecedented selectivity of 97% and a false-positive detection value of 2.0%. Multivalent binding of the phage bioconjugates with the receptor provided significantly better specificity and sensitivity allowing application of engineered bacteriophage bioconjugates at a concentration 3 orders of magnitude lower in comparison with synthetic biotinylated peptide. We suggest that the platform described in this work may be applied either for routine staining or characterization of orphan membrane receptors exposed on the surface of living mammalian cells in their native environment.

41. High-Throughput Platform for B-Cell Screening Based on Fluorescent Phage-Display Technology

Author

Lomakin Y., Kaminskaya A., Stepanov A., Shmidt A., Gabibov A., Belogurov A., Lomakin Y., Kaminskaya A., Stepanov A., Shmidt A., Gabibov A., and Belogurov A.

Abstract

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. A system for detection of malignantly transformed cells, including follicular lymphoma Bcells, was developed and experimentally validated. The system is based on the use of bacteriophages carrying exposed ligands for pathogenic B-cell receptors. The efficiency of binding to target cells is several times higher than in systems with chemically synthesized biotinylated peptides. The new method is proposed as a noninvasive diagnostic test for mapping B-cell lymphoma and for determining the specificity of B-cell receptors and high-throughput combinatorial selection of various repertories of B cells.

42. Differential Diagnostics of Active Progressing Multiple Sclerosis Using a Fluorescent Biomarker with Resonance Energy Transfer

Author

Lomakin Y., Kudryaeva A., Kostin N., Terekhov S., Kaminskaya A., Zakharova M., Ivanova M., Simaniv T., Gabibov A., Belogurov A., Lomakin Y., Kudryaeva A., Kostin N., Terekhov S., Kaminskaya A., Zakharova M., Ivanova M., Simaniv T., Gabibov A., and Belogurov A.

Abstract

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Previous data showed that myelin-reactive autoantibodies found in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis recognize and hydrolyze various fragments of myelin basic protein (MBP). Moreover, antibody-mediated cleavage of the encephalithogenic fragment MBP81-103 flanked with two fluorescent proteins can serve as a new biomarker of multiple sclerosis. Here we describe creation of the next generation of this biomarker based on antibody-dependent degradation of a new chemically synthesized fluorescent substrate with resonance energy transfer that contains fluorophore Cy5 and quencher QXL680 separated by MBP81-99 protein (Cy5-MBP81-99-QXL680). This substrate is degraded during incubation with purified antibodies and B cells from patients with multiple sclerosis, but not healthy volunteers.

43. Diagnostics of autoimmune neurodegeneration using fluorescent probing

Author

Lomakin Y., Kudriaeva A., Kostin N., Terekhov S., Kaminskaya A., Chernov A., Zakharova M., Ivanova M., Simaniv T., Telegin G., Gabibov A., Belogurov A., Lomakin Y., Kudriaeva A., Kostin N., Terekhov S., Kaminskaya A., Chernov A., Zakharova M., Ivanova M., Simaniv T., Telegin G., Gabibov A., and Belogurov A.

Abstract

© 2018, The Author(s). The discovery of antibody-mediated catalysis was a breakthrough that showed antibody function is not limited to specific binding interactions, and that immunoglobulins (Igs) may also chemically transform their target antigens. Recently, so-called “natural catalytic antibodies” have been intimately linked with several pathologies, where they either protect the organism or contribute to the development of autoimmune abnormalities. Previously, we showed that myelin-reactive autoantibodies from patients with multiple sclerosis (MS) and mice with experimental autoimmune encephalomyelitis (EAE) exhibit the ability to recognize and hydrolyse distinct epitopes within myelin basic protein (MBP). Further, the antibody-mediated cleavage of encephalitogenic MBP peptide 81–103, flanked by two fluorescent proteins, can serve as a novel biomarker for MS. Here, we report the next generation of this biomarker, based on the antibody-mediated degradation of a novel chemically synthesized FRET substrate, comprising the fluorophore Cy5 and the quencher QXL680, interconnected by the MBP peptide 81–99: Cy5-MBP81–99-QXL680. This substrate is degraded upon incubation with either purified antibodies from MS patients but not healthy donors or purified antibodies and splenocytes from EAE but not from non-immunized mice. Data presented herein suggest the elaboration of potential specific, rapid, and sensitive diagnostic criteria of active progressive MS.

44. Myelin-Reactive Monoclonal Antibodies from Multiple Sclerosis Patients Cross-React with Nucleoproteins in HEp-2 Lysate

Author

Lomakin Y., Shmidt A., Glagoleva I., Okunola J., Vaskina M., Belogurov A., Gabibov A., Lomakin Y., Shmidt A., Glagoleva I., Okunola J., Vaskina M., Belogurov A., and Gabibov A.

Abstract

© 2016, Springer Science+Business Media New York.Autoimmune disorders are characterized by appearance of self-reactive species of immune system such as T cells, B cells and antibodies. For the majority of autoimmune pathologies the list of specific autoantigens is known. Myelin basic protein (MBP) is one of the most important autoantigens in multiple sclerosis (MS), which destruction is a hallmark of disease progression. Antibodies toward MBP are found in serum and cerebrospinal fluid of MS patients. Here we investigated whether monoclonal human MBP-specific antibodies selected from MS patients repertoire cross-react with other autoimmune markers. For this purpose we performed Western blot analysis of recombinant anti-MBP antibodies with HEp-2 cell lysate. Our data suggest existence of enhanced level of cross-reactivity of anti-MBP antibodies with ribonucleoprotein A (RNP A), a marker of Sharp’s syndrome and systemic lupus erythematosus, ribosomal P protein (Rib. P-Prot), a marker for systemic lupus erythematosus, and centromere protein A/B (CENP A/B), markers for progressive systemic sclerosis.

45. Single-Molecule Interactions of a Monoclonal Anti-DNA Antibody with DNA

Author

Nevzorova T., Zhao Q., Lomakin Y., Ponomareva A., Mukhitov A., Purohit P., Weisel J., Litvinov R., Nevzorova T., Zhao Q., Lomakin Y., Ponomareva A., Mukhitov A., Purohit P., Weisel J., and Litvinov R.

Abstract

© 2016, Springer Science+Business Media New York.Interactions of DNA with proteins are essential for key biological processes and have both a fundamental and practical significance. In particular, DNA binding to anti-DNA antibodies is a pathogenic mechanism in autoimmune pathology, such as systemic lupus erythematosus. Here we measured at the single-molecule level binding and forced unbinding of surface-attached DNA and a monoclonal anti-DNA antibody MRL4 from a lupus erythematosus mouse. In optical trap-based force spectroscopy, a microscopic antibody-coated latex bead is trapped by a focused laser beam and repeatedly brought into contact with a DNA-coated surface. After careful discrimination of non-specific interactions, we showed that the DNA-antibody rupture force spectra had two regimes, reflecting formation of weaker (20–40 pN) and stronger (>40 pN) immune complexes that implies the existence of at least two bound states with different mechanical stability. The two-dimensional force-free off-rate for the DNA-antibody complexes was ∼2.2 × 10−3 s−1, the transition state distance was ∼0.94 nm, the apparent on-rate was ∼5.26 s−1, and the stiffness of the DNA-antibody complex was characterized by a spring constant of 0.0021 pN/nm, suggesting that the DNA-antibody complex is a relatively stable, but soft and deformable macromolecular structure. The stretching elasticity of the DNA molecules was characteristic of single-stranded DNA, suggesting preferential binding of the MRL4 antibody to one strand of DNA. Collectively, the results provide fundamental characteristics of formation and forced dissociation of DNA-antibody complexes that help to understand principles of DNA-protein interactions and shed light on the molecular basis of autoimmune diseases accompanied by formation of anti-DNA antibodies.

46. Divergent immunomodulation capacity of individual myelin peptides-components of liposomal therapeutic against multiple sclerosis

Author

Ivanova V., Khaiboullina S., Gomzikova M., Martynova E., Ferreira A., Garanina E., Sakhapov D., Lomakin Y., Khaibullin T., Granatov E., Khabirov F., Rizvanov A., Gabibov A., Belogurov A., Ivanova V., Khaiboullina S., Gomzikova M., Martynova E., Ferreira A., Garanina E., Sakhapov D., Lomakin Y., Khaibullin T., Granatov E., Khabirov F., Rizvanov A., Gabibov A., and Belogurov A.

Abstract

© 2017 Ivanova, Khaiboullina, Gomzikova, Martynova, Ferreira, Garanina, Sakhapov, Lomakin, Khaibullin, Granatov, Khabirov, Rizvanov, Gabibov and Belogurov. Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and consequent neuron injury. Although the pathogenesis of MS is largely unknown, a breach in immune self-tolerance to myelin followed by development of autoreactive encephalitogenic T cells is suggested to play the central role. The myelin basic protein (MBP) is believed to be one of the main targets for autoreactive lymphocytes. Recently, immunodominant MBP peptides encapsulated into the mannosylated liposomes, referred as Xemys, were shown to suppress development of experimental autoimmune encephalomyelitis, a rodent model of MS, and furthermore passed the initial stage of clinical trials. Here, we investigated the role of individual polypeptide components [MBP peptides 46-62 (GH17), 124-139 (GK16), and 147-170 (QR24)] of this liposomal peptide therapeutic in cytokine release and activation of immune cells from MS patients and healthy donors. The overall effects were assessed using peripheral blood mononuclear cells (PBMCs), whereas alterations in antigen-presenting capacities were studied utilizing plasmacytoid dendritic cells (pDCs). Among three MBP-immunodominant peptides, QR24 and GK16 activated leukocytes, while GH17 was characterized by an immunosuppressive effect. Peptides QR24 and GK16 upregulated CD4 over CD8 T cells and induced proliferation of CD25 + cells, whereas GH17 decreased the CD4/CD8 T cell ratio and had limited effects on CD25 + T cells. Accordingly, components of liposomal peptide therapeutic differed in upregulation of cytokines upon addition to PBMCs and pDCs. Peptide QR24 was evidently more effective in upregulation of pro-inflammatory cytokines, whereas GH17 significantly increased production of IL-10 through treated cells. Altogether, these data suggest a complexity of action of the liposomal peptide thera

47. Exposure to the Epstein-Barr viral antigen latent membrane protein 1 induces myelin-reactive antibodies in vivo

Author

Lomakin Y., Arapidi G., Chernov A., Ziganshin R., Tcyganov E., Lyadova I., Butenko I., Osetrova M., Ponomarenko N., Telegin G., Govorun V., Gabibov A., Belogurov A., Lomakin Y., Arapidi G., Chernov A., Ziganshin R., Tcyganov E., Lyadova I., Butenko I., Osetrova M., Ponomarenko N., Telegin G., Govorun V., Gabibov A., and Belogurov A.

Abstract

© 2017 Lomakin, Arapidi, Chernov, Ziganshin, Tcyganov, Lyadova, Butenko, Osetrova, Ponomarenko, Telegin, Govorun, Gabibov and Belogurov. Multiple sclerosis (MS) is an autoimmune chronic inflammatory disease of the central nervous system (CNS). Cross-reactivity of neuronal proteins with exogenous antigens is considered one of the possible mechanisms of MS triggering. Previously, we showed that monoclonal myelin basic protein (MBP)-specific antibodies from MS patients cross-react with Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1). In this study, we report that exposure of mice to LMP1 results in induction of myelin-reactive autoantibodies in vivo. We posit that chronic exposure or multiple acute exposures to viral antigen may redirect B cells from production of antiviral antibodies to antibodies, specific to myelin antigen. However, even in inbred animals, which are almost identical in terms of their genomes, such an effect is only observed in 20-50% of animals, indicating that this change occurs by chance, rather than systematically. Cross-immunoprecipitation analysis showed that only part of anti-MBP antibodies from LMP1-immunized mice might simultaneously bind LMP1. In contrast, the majority of anti-LMP1 antibodies from MBP-immunized mice bind MBP. De novo sequencing of anti-LMP1 and anti-MBP antibodies by mass spectrometry demonstrated enhanced clonal diversity in LMP1-immunized mice in comparison with MBP-immunized mice. We suggest that induction of MBP-reactive antibodies in LMP1-immunized mice may be caused by either Follicular dendritic cells (FDCs) or by T cells that are primed by myelin antigens directly in CNS. Our findings help to elucidate the still enigmatic link between EBV infection and MS development, suggesting that myelin-reactive antibodies raised as a response toward EBV protein LMP1 are not truly cross-reactive but are primarily caused by epitope spreading.

48. Peptides against autoimmune neurodegeneration

Author

Stepanov A., Lomakin Y., Gabibov A., Belogurov A., Stepanov A., Lomakin Y., Gabibov A., and Belogurov A.

Abstract

© 2017 Bentham Science Publishers. The mammalian immune system is a nearly perfect defensive system polished by a hundred million years of evolution. Unique flexibility and adaptivity have created a virtually impenetrable barrier to numerous exogenous pathogens that are assaulting us every moment. Unfortunately, triggers that remain mostly enigmatic will sometimes persuade the immune system to retarget against self-antigens. This civil war remains underway, showing no mercy and taking no captives, eventually leading to irreversible pathological changes in the human body. Research that has emerged during the last two decades has given us hope that we may have a chance to overcome autoimmune diseases using a variety of techniques to "reset" the immune system. In this report, we summarize recent advances in utilizing short polypeptides - mostly fragments of autoantigens - in the treatment of autoimmune neurodegeneration.

49. Analysis of Immunogenicity of Intracellular CTAR Fragments of Epstein—Barr Virus Latent Phase Protein LMP1

Author

Lomakin Y., Shmidt A., Bobik T., Chernov A., Pyrkov A., Aleksandrova N., Okunola D., Vaskina M., Ponomarenko N., Telegin G., Dubina M., Belogurov A., Lomakin Y., Shmidt A., Bobik T., Chernov A., Pyrkov A., Aleksandrova N., Okunola D., Vaskina M., Ponomarenko N., Telegin G., Dubina M., and Belogurov A.

Abstract

© 2017, Springer Science+Business Media, LLC. Intracellular fragments of latent phase protein LMP1 of Epstein—Barr virus, denoted as CTAR1/2/3, can trigger a variety of cell cascades and contribute to the transforming potential of the virus. Generation of recombinant proteins CTAR1/2/3 is expected to yield more ample data on functional and immunogenic characteristics of LMP1. We created genetic constructs for prokaryotic expression of LMP1 CTAR fragments and selected optimal conditions for their production and purification. Using a new library of LMP1 CTAR fragments, we carried out epitope mapping of a diagnostic anti-LMP1 antibody S12. Analysis of polyclonal serum antibodies from mice immunized with full-length LMP1 confirmed immunogenicity of CTAR elements comparable with that of full-length protein.

50. Peptides against autoimmune neurodegeneration

Author

Stepanov A., Lomakin Y., Gabibov A., Belogurov A., Stepanov A., Lomakin Y., Gabibov A., and Belogurov A.

Abstract

© 2017 Bentham Science Publishers. The mammalian immune system is a nearly perfect defensive system polished by a hundred million years of evolution. Unique flexibility and adaptivity have created a virtually impenetrable barrier to numerous exogenous pathogens that are assaulting us every moment. Unfortunately, triggers that remain mostly enigmatic will sometimes persuade the immune system to retarget against self-antigens. This civil war remains underway, showing no mercy and taking no captives, eventually leading to irreversible pathological changes in the human body. Research that has emerged during the last two decades has given us hope that we may have a chance to overcome autoimmune diseases using a variety of techniques to "reset" the immune system. In this report, we summarize recent advances in utilizing short polypeptides - mostly fragments of autoantigens - in the treatment of autoimmune neurodegeneration.

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