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Introduction: The purpose of this study was to determine the most common orthopedic diagnoses and procedures among patients who experience domestic violence (DV) and to determine whether these were more common in patients who experienced DV compared with those who did not., Methods: We performed a retrospective cohort study of all patients identified in the National Trauma Data Bank. Patients were divided into two cohorts for comparison: victims of DV and all other patients. The main outcome measurements were a diagnosis of an orthopedic injury and/or a procedure performed for an orthopedic diagnosis., Results: In total, 1,204,596 patients were included in the analysis, of whom 3191 (0.26%) were victims of DV. Adult trauma patients with DV were more likely to have a diagnosis of neck and back sprain (odds ratio 1.98, 95% confidence interval 1.60 to 2.44, P < 0.0001) and more likely to undergo surgical repair of the flexor tendon of the hand (odds ratio 2.76, 95% confidence interval 1.75 to 4.35, P < 0.0001) than patients without a diagnosis of DV., Discussion: Patients who experience DV were more likely to have back and neck sprain and more likely to undergo repair of flexor tendon of the hand than those who do not experience DV., (Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Orthopaedic Surgeons.)