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177 results on '"Liu, J.H."'

6. Niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer using an individualized starting dose (NORA): a randomized, double-blind, placebo-controlled phase III trial☆

Author

Wu, X.H., Zhu, J.Q., Yin, R.T., Yang, J.X., Liu, J.H., Wang, J., Wu, L.Y., Liu, Z.L., Gao, Y.N., Wang, D.B., Lou, G., Yang, H.Y., Zhou, Q., Kong, B.H., Huang, Y., Chen, L.P., Li, G.L., An, R.F., Wang, K., Zhang, Y., Yan, X.J., Lu, X., Lu, W.G., Hao, M., Wang, L., Cui, H., Chen, Q.H., Abulizi, G., Huang, X.H., Tian, X.F., Wen, H., Zhang, C., Hou, J.M., and Mirza, M.R.

Published
2021
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24. REGENERATING GENE IA PREDICTS RADIOSENSITIVITY AND SURVIVAL IN NASOPHARYNGEAL CARCINOMA.

Author

XING, H.J., CHEN, X.D., SUN, H.X., DAI, Y., HAN, Y.F., DING, L.L., LIU, J.H., and CHEN, H.B.

Abstract

Nasopharyngeal carcinoma (NPC) is a common malignancy in Southern China and Southeast Asia. Radiotherapy is the main treatment option. However, radiotherapy does not benefit all patients because there is no known precise biomarker that can be used for screening radioresistant patients. Genetic predisposition is closely related to tumor development, therapeutic response, and prognosis. The relationship between regenerating gene IA (REGIA) and NPC is unclear. This study aimed to retrospectively analyze the association between REGIA expression and metastasis, radiosensitivity, and survival in patients with NPC as well as assess the effect of radiation on REGIA expression in vitro. Immunohistochemical staining was used to detect REGIA. The relationship between REGIA expression in radioresistant NPC and the prognosis of CNE1 NPC cells were analyzed using quantitative real-time polymerase chain reaction and Western blotting. We found that increased doses of radiation in CNE1 cells significantly decreased REGIA expression (P<0.05). The overall rate of REGIA-positive expression was 47.15% in NPC tissues and 45.00% and 61.02% in radiosensitive and radioresistant cases, respectively, showing significant differences (P<0.05). A REGIA-positive protein expression rate had a negative correlation with radiosensitivity in NPC (r= –0.109, P=0.047). Both REGIApositive and REGIA-negative expression strongly predicted the overall survival rate and progression-free survival of NPC patients (P<0.01). A multivariate analysis indicated that REGIA was an inverse prognostic factor in NPC patients (REGIA-positive expression: hazard ratio (HR)=2.139, 95% confidence interval (CI)=1.56–2.94, P<0.001 and REGIAnegative expression: HR=1.958, 95% CI=1.42–2.69, P<0.001). In conclusion: Radiation can affect REGIA expression. The REGIA expression level correlated with radioresistance and a poor prognosis. In addition, REGIA expression might act as a potential therapeutic target and prognostic predictor in NPC patients. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Environmental planning, biodiversity and the development process: the case of Hong Kong's Chinese white dolphins

Author

Liu, J.H. and Hills, Peter

Subjects
Hong Kong -- Environmental aspects, Environmental protection -- Hong Kong, Dolphins -- Protection and preservation, Environmental issues
Abstract

The controversy regarding the fate of the Chinese white dolphin (Sousa chinensis) was addressed. The habitat and future existence of the local Indo-Pacific humped-back dolphin in Hongkong is threatened by marine pollution, fishing, increasing shipping movements and major infrastructure projects. A dolphin sanctuary within a designated marine park area was proposed. Lack of an overall conservation strategy, shortcomings in the territory's environmental impact assessment system, and the limited local scientific knowledge concerning the dolphin population were cited as causes of the dolphin problem.

Published
1997

28. Mass measurements of neutron-deficient Y, Zr, and Nb isotopes and their impact on rp and νp nucleosynthesis processes

Author

Xing, Y.M., Li, K.A., Zhang, Y.H., Zhou, X.H., Wang, M., Litvinov, Yu.A., Blaum, K., Wanajo, S., Kubono, S., Martínez-Pinedo, G., Sieverding, A., Chen, R.J., Shuai, P., Fu, C.Y., Yan, X.L., Huang, W.J., Xu, X., Tang, X.D., Xu, H.S., Bao, T., Chen, X.C., Gao, B.S., He, J.J., Lam, Y.H., Li, H.F., Liu, J.H., Ma, X.W., Mao, R.S., Si, M., Sun, M.Z., Tu, X.L., Wang, Q., Yang, J.C., Yuan, Y.J., Zeng, Q., Zhang, P., Zhou, X., Zhan, W.L., Litvinov, S., Audi, G., Uesaka, T., Yamaguchi, Y., Yamaguchi, T., Ozawa, A., Fröhlich, C., Rauscher, T., Thielemann, F.-K., Sun, B.H., Sun, Y., Dai, A.C., and Xu, F.R.

Published
2018
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31. Committee II.2: Dynamic Response

Author

Ergin, A., Alley, E., Brandt, A., Drummen, I, Hermundstad, Ole Andreas, Huh, Y.C., Ivaldi, A., Liu, J.H., Malenica, S., El Moctar, Ould, Shyu, R.J., Storhaug, G., Vladimir, N., Yamada, Y., Zhan, D., and Zhang, G.

Abstract

Concern for the dynamic structural response of ships and offshore structures as required for safety and serviceability assessments, including habitability. This should include steady state, transient and random response. Attention shall be given to dynamic responses resulting from environmental, machinery and propeller excitation. Uncertainties associated with modelling should be highlighted.

Published
2018

50. Rapid analysis of pyrethroid insecticides in aquaculture seawater samples via membrane-assisted solvent extraction coupled with gas chromatography-electron capture detection

Author

Shi, X.Z., Song, S.Q., Sun, A.L., Liu, J.H., Li, D.X., and Chen, J.

Abstract

A simple, efficient, and environmentally friendly membrane-assisted solvent extraction (MASE) method for the extraction and preconcentration of six pyrethroid insecticides from aquaculture seawater samples followed by gas chromatography-electron capture detection (GC-ECD) was successfully proposed. The operating conditions for MASE, such as the extraction solvent, solvent volume, NaCl concentration, stirring rate, extraction time, and temperature, were optimized. Compared to conventional Florisil-solid phase extraction (SPE), higher extraction recoveries (85.9% to 105.9%) of three spiked levels of the six pyrethroid pesticides in aquaculture seawater were obtained using MASE, and the RSD values were lower than 7.9%. The limits of detection (LOD, signal-to-noise ratio (S/N)=3) and quantification (LOQ, S/N = 10) were in the range of 0.037–0.166 and 0.12–0.55 µg L-1, respectively. The results demonstrate the excellent applicability of the MASE method in analyzing the six pyrethroid pesticides in aqueous samples. The proposed method exhibited a high potential for routine monitoring analysis of pyrethroid insecticides in seawater samples.

Published
2012

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