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6. Protective Effects of Enzymatic Products from Sturgeon Roe on Alcohol-induced Hepatic Cell Damage and Virtual Screening of Active Peptides.

Author

ZHANG Lijun, ZHAO Tiantian, CHEN Jieqiong, ZHONG Kangrong, GUAN Yongjian, LUO Rui, LIN Chunyan, NAN Haijun, and ZHANG Yehui

Subjects
ALCOHOL dehydrogenase, ALKALINE protease, AQUATIC resources, SUPEROXIDE dismutase, ASPARTATE aminotransferase
Abstract

This study was designed to explore the hepatoprotective effects of enzymatic degradation products derived from sturgeon roe on alcohol-damaged hepatocytes and to elucidate the underlying mechanisms. Utilizing sturgeon roe as the research material, the enzymatic process was optimized by focusing on key parameters such as enzymatic efficiency and in vitro activity. The protective effects on hepatocytes were systematically investigated by using the HepG2 cell model. Advanced computerized virtual screening technology was employed to identify potential bioactive peptides within the sturgeon roe. The findings indicated that the optimum enzymatic product of sturgeon roe was obtained under the conditions of 1:1 compounding of alkaline protease (1343 U/g) and trypsin (27 U/g) for 8 h, yielded a protein recovery of 49.30%±0.57%, a hydrolysis degree of 46.05%±0.92%, and ABTS+ free radical scavenging rate of 51.45%±0.66%. Notably, at a concentration of 5 mg/mL, this product significantly enhanced the activity of alcohol dehydrogenase (ADH) by 168.64%±1.42% (P<0.05). The product prepared under this enzymatic condition at 0.3~2 mg/mL significantly elevated superoxide dismutase (SOD) activity, glutathione (GSH) contents, and reduced malondialdehyde (MDA) contents in alcohol-injured HepG2 cells compared to the model group (P<0.05). In addition, the product at 0.3~2 mg/mL also significantly reduced alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities (P<0.05). Virtual screening identified 5 peptides, including LPG and FLPR, in the sturgeon roe enzymatic degradation product, showed promising hepatoprotective properties against alcohol-induced hepatocyte injury. Consequently, this study lays a solid foundation for the further development and utilization of aquatic resources, such as sturgeon roe, in hepatoprotective applications. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway

Author

Ye,Guangyao, Lin,Chunyan, Zhang,Yu, Ma,Zihan, Chen,Yuebo, Kong,Lingsi, Yuan,Liyong, Ma,Tao, Ye,Guangyao, Lin,Chunyan, Zhang,Yu, Ma,Zihan, Chen,Yuebo, Kong,Lingsi, Yuan,Liyong, and Ma,Tao

Abstract

Guangyao Ye,1,* Chunyan Lin,1,* Yu Zhang,1 Zihan Ma,2 Yuebo Chen,1 Lingsi Kong,1 Liyong Yuan,1 Tao Ma3 1Department of Anesthesiology, Ningbo No.6 Hospital, Ningbo, 315040, People’s Republic of China; 2School of Medicine, Ningbo University, Ningbo, 315211, People’s Republic of China; 3Department of Anesthesiology and Pharmacology, Xuzhou Medical University, Xuzhou, 221000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liyong YuanDepartment of Anesthesiology, Ningbo No.6 Hospital, Ningbo, 315040, People’s Republic of ChinaEmail yuanl1973@yeah.netTao MaDepartment of Anesthesiology and Pharmacology, Xuzhou Medical University, Xuzhou, 221000, People’s Republic of ChinaEmail Matao201006@126.comContext: Quercetin (que) is one abundant flavonol with a variety of biological activities. Previous studies have shown quercetin can reduce neuropathic pain in rats with chronic constriction injury (CCI).Objective: To evaluate the effects of quercetin on neuropathic pain in CCI model and explore its underlying mechanism in vivo.Materials and Methods: CCI model was established by ligating the sciatic nerve of right leg on the SD rats. They were divided into ten groups: sham group, CCI model, sham+ que, CCI+ que group (30, 60, 120 mg/kg), CCI+ AICAR, CCI+ que+ compound C, CCI+etoricoxib, and the control group. They were administered for 28 days, and were performed the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) during the experiment. At the end of the experiment, sciatic nerves and spinal cord segments of rats were collected, ELISA detected the expression of inflammatory factors, detected the microglia and astrocytes with fluorescence, and Western blot detected AMPK/MAPK pathway.Results: Que could increase the MWT of CCI rats, improve the TWL of plantar, and reduce the inflammatory cells at the ligation site of the sciatic nerve. Also, que could reduce the levels

Published
2021

28. Molecular epidemiology of measles viruses in China, 1995–2003

Author

Ma Yujie, Yang Xiuhui, Liu Wei, Ba Zhuoma, Zhou Shunde, Lu Yiyu, Zhang Jinlin, Yang Xuelei, Zhang Hong, Yan Xinge, Liu Guiyan, Zhou Jianhui, He Weikuan, Guan Ronghui, Li Ping, Ma Yan, Tian Jiang, He Jilan, Lin Chunyan, Zhao Chunfang, Ling Hua, Tian Hong, Zheng Lei, Wang Tongzhan, Li Congyong, Wang Changyin, Tang Wei, Zhang Zhenying, Hu Jiayu, Wang Jianguo, Rota Paul A, Jiang Xiaohong, Zhu Zhen, Zhang Yan, Liang Yong, Li Yeqiang, Ji Yixin, Featherstone David, Bellini William J, Xu Songtao, Liang Guodong, and Xu Wenbo

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces of China between 1995 and 2003. Phylogenetic analysis of the N gene sequences showed that all of the isolates belonged to genotype H1 except 3 isolates, which were genotype A. The nucleotide sequence and predicted amino acid homologies of the 294-genotype H1 strains were 94.7%–100% and 93.3%–100%, respectively. The genotype H1 isolates were divided into 2 clusters, which differed by approximately 2.9% at the nucleotide level. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Even though other measles genotypes have been detected in countries that border China, this report shows that genotype H1 is widely distributed throughout the country and that China has a single, endemic genotype. This important baseline data will help to monitor the progress of measles control in China.

Published
2007
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30. RETRACTED: Research on Application of Automatic Weather Station Based on Internet of Things

Author

Sun Yunfan, Chen Jianyun, and Lin Chunyan

Subjects
Automatic weather station, business.industry, Environmental science, General Medicine, General Chemistry, Internet of Things, business, Telecommunications
Abstract

In this paper, the Internet of Things is briefly introduced, and then its application in the weather station is studied. A method of data acquisition and transmission based on NB-iot communication mode is proposed, Introduction of Internet of things technology, Sensor digital and independent power supply as the technical basis, In the construction of Automatic To realize the intelligent interconnection of the automatic weather station, and then to form an automatic weather station based on the Internet of things. A network structure of automatic weather station based on Internet of things technology is constructed to realize the independent operation of intelligent sensors and wireless data transmission. Research on networking data collection and dissemination of meteorological data, through the data platform for data analysis, the preliminary work of meteorological information publishing standards, networking of meteorological information receiving terminal provides the data interface, to the wisdom of the city, the wisdom of the purpose of the meteorological service.

Published
2017

33. Automatic Alignment Fiber Optic Coupling System for Optimal Signal Transmission

Author

SPACE AND NAVAL WARFARE SYSTEMS CENTER PACIFIC SAN DIEGO CA ADVANCED TECHNOLOGY BRANCH (55430), Lu, Ryan P, Lin, Chunyan, Ramirez, Ayax D, Garcia, Gabe V, SPACE AND NAVAL WARFARE SYSTEMS CENTER PACIFIC SAN DIEGO CA ADVANCED TECHNOLOGY BRANCH (55430), Lu, Ryan P, Lin, Chunyan, Ramirez, Ayax D, and Garcia, Gabe V

Abstract

This report describes an automated alignment system developed to aid in the process to evaluate the optical characteristics of waveguides that are manufactured for research in optical communications. Using the current method of characterizing the waveguides, it can take up to 8 hours to characterize the waveguides on a single silicon wafer. Using the computer automation system developed, the characterization process has been reduced to less than an hour., The original document contains color images. Prepared in collaboration with New Mexico State University, Las Cruces. Sponsored in part by DARPA.

Published
2014

34. Molecular epidemiology of measles viruses in China, 1995–2003

Author

Zhang, Yan, Zhu, Zhen, Rota, Paul A, Jiang, Xiaohong, Hu, Jiayu, Wang, Jianguo, Tang, Wei, Zhang, Zhenying, Li, Congyong, Wang, Changyin, Wang, Tongzhan, Zheng, Lei, Tian, Hong, Ling, Hua, Zhao, Chunfang, Ma, Yan, Lin, Chunyan, He, Jilan, Tian, Jiang, Li, Ping, Guan, Ronghui, He, Weikuan, Zhou, Jianhui, Liu, Guiyan, Zhang, Hong, Yan, Xinge, Yang, Xuelei, Zhang, Jinlin, Lu, Yiyu, Zhou, Shunde, Ba, Zhuoma, Liu, Wei, Yang, Xiuhui, Ma, Yujie, Liang, Yong, Li, Yeqiang, Ji, Yixin, Featherstone, David, Bellini, William J, Xu, Songtao, Liang, Guodong, Xu, Wenbo, Zhang, Yan, Zhu, Zhen, Rota, Paul A, Jiang, Xiaohong, Hu, Jiayu, Wang, Jianguo, Tang, Wei, Zhang, Zhenying, Li, Congyong, Wang, Changyin, Wang, Tongzhan, Zheng, Lei, Tian, Hong, Ling, Hua, Zhao, Chunfang, Ma, Yan, Lin, Chunyan, He, Jilan, Tian, Jiang, Li, Ping, Guan, Ronghui, He, Weikuan, Zhou, Jianhui, Liu, Guiyan, Zhang, Hong, Yan, Xinge, Yang, Xuelei, Zhang, Jinlin, Lu, Yiyu, Zhou, Shunde, Ba, Zhuoma, Liu, Wei, Yang, Xiuhui, Ma, Yujie, Liang, Yong, Li, Yeqiang, Ji, Yixin, Featherstone, David, Bellini, William J, Xu, Songtao, Liang, Guodong, and Xu, Wenbo

Abstract

This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces of China between 1995 and 2003. Phylogenetic analysis of the N gene sequences showed that all of the isolates belonged to genotype H1 except 3 isolates, which were genotype A. The nucleotide sequence and predicted amino acid homologies of the 294-genotype H1 strains were 94.7%–100% and 93.3%–100%, respectively. The genotype H1 isolates were divided into 2 clusters, which differed by approximately 2.9% at the nucleotide level. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Even though other measles genotypes have been detected in countries that border China, this report shows that genotype H1 is widely distributed throughout the country and that China has a single, endemic genotype. This important baseline data will help to monitor the progress of measles control in China.

Published
2007

36. Molecular epidemiology of measles viruses in China, 1995–2003

Author

Zhang, Yan, primary, Zhu, Zhen, additional, Rota, Paul A, additional, Jiang, Xiaohong, additional, Hu, Jiayu, additional, Wang, Jianguo, additional, Tang, Wei, additional, Zhang, Zhenying, additional, Li, Congyong, additional, Wang, Changyin, additional, Wang, Tongzhan, additional, Zheng, Lei, additional, Tian, Hong, additional, Ling, Hua, additional, Zhao, Chunfang, additional, Ma, Yan, additional, Lin, Chunyan, additional, He, Jilan, additional, Tian, Jiang, additional, Li, Ping, additional, Guan, Ronghui, additional, He, Weikuan, additional, Zhou, Jianhui, additional, Liu, Guiyan, additional, Zhang, Hong, additional, Yan, Xinge, additional, Yang, Xuelei, additional, Zhang, Jinlin, additional, Lu, Yiyu, additional, Zhou, Shunde, additional, Ba, Zhuoma, additional, Liu, Wei, additional, Yang, Xiuhui, additional, Ma, Yujie, additional, Liang, Yong, additional, Li, Yeqiang, additional, Ji, Yixin, additional, Featherstone, David, additional, Bellini, William J, additional, Xu, Songtao, additional, Liang, Guodong, additional, and Xu, Wenbo, additional

Published
2007
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