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Yan Lin,1,* Xing Gao,1,* Ziyu Liu,1 Zhihui Liu,1 Yongqiang Li,1 Rong Liang,1 Zhiling Liao,2 Jiazhou Ye3 1Department of Medical Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People’s Republic of China; 2Department of Pathology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People’s Republic of China; 3Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rong Liang, Department of Medical Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China, Tel +86 771 5335155, Fax +86 771 5335155, Email liangrong@gxmu.edu.cn Jiazhou Ye, Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China, Tel +86 771 5331211, Fax +86 771 5331211, Email yejiazhou@gxmu.edu.cnAbstract: Low-grade myofibroblastic sarcoma (LGMS) is a rare, poorly differentiated, malignant tumor. The disease mainly occurs in the head and neck and rarely metastasizes at any age. Currently, there is no consensus regarding the treatment of metastatic LGMS. Here, we report the case of a 45-year-old man who was admitted to our hospital with cough for two weeks and abdominal pain for one week. Preoperative computed tomography revealed a large mass (116× 35 mm) in both the lungs and jejunal mass (maximum diameter, 32 mm). The tumor was excised, and immunohistochemical staining was positive for SMA and CD117 and negative for desmin and CD34, indicating a case of LGMS. The patient was effectively treated with apatinib (250 mg/day) after failure of imatinib, liposomal doxorubicin, and ifosfamide. The progression-free survival time was 8.5 months, and the overall survival time was 17 months after treatment with apatinib. No grade 3 or 4 side effects were observed, except hand-foot syndrome. Whole-exome sequencing (WES) and RNA sequencing (RNA-seq) were performed on the patient’s jejunal tumor and para-cancerous tissue samples, and bioinformatics analysis was performed on the results. WES identified five mutations in MKI67, OR2J2, EPPK1, FCGBP, and OR10G4. RNA-seq revealed that 1422 genes were upregulated and 1890 genes were downregulated. The differentially expressed genes were mainly enriched in the phosphatidylinositol 3-kinase (PI3K) signaling pathway, neuroactive ligand-receptor interaction signaling pathway, and cAMP signaling pathway. Our study indicated that apatinib may be a potential novel and effective treatment for LGMS.Keywords: low-grade myofibroblastic sarcoma, apatinib, VEGFR-PI3K/Akt signaling pathway, whole-exome sequencing, RNA sequencing

Notice of Violation of IEEE Publication Principles “Single-Phase Common-Ground-Type Transformerless PV Grid-Connected Inverters” By Zhiling Liao, Chenchen Cao , Diancheng Qiu, and Changbo Xu In IEEE Access, Vol 7, 2019 After careful and considered review of the content and authorship of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE’s Publication Principles. The content of this paper contains significant similarities with the paper cited below that were presented with insufficient attribution. “Common-Ground-Type Transformerless Inverters for Single-Phase Solar Photovoltaic Systems” by Yam P. Siwakoti and Frede Blaabjerg in IEEE Transactions on Industrial Electronics, Vol. 65, No. 3, March 2018 This paper presents a family of novel common-ground-type transformerless photovoltaic (PV) grid-connected inverters, which requires only five power switches, one capacitor, and one filter. A simple dual-closed led-loop control is used to improve control stabilization and accuracy. The main advantages of proposed inverters are: 1) the leakage current is completely eliminated (unlike traditional topologies, which can only suppress leakage current); 2) the devices used are a few and the cost is low; 3) low loss and high efficiency; 4) the ability of realizing reactive power; and 5) there is no need for high DC input voltage compared with half-bridge-type topologies. The operating principle, modulation mode, and control strategy are introduced in detail. The performance of the proposed topology is compared with that of several traditional topologies. The leakage current suppression ability and efficiency of the proposed topology are superior to those of the traditional topologies. The model predictive control (MPC) is applied in the proposed topology, which is easy to realize and can accelerate the dynamic response. Finally, the simulation and experimental results of a 1-kVA prototype are given, which proves the validity of the proposed topology in PV grid-connected system.