Search

The incidence of cerebral apoplexy has been on the rise in recent years, and research on the treatment and care of this disease has also received much attention. Therefore, a clinical study of neurological care for cerebral apoplexy rehabilitation care was conducted. Firstly, the Diffie-Hellman key exchange algorithm is introduced, and then the Diffie-Hellman prediction model is established. The patient is taken as an example to carry out simulation test, and the prediction model is compared with the real data. The data of the network model training set, the verification set and the test set are obtained. Patients were divided into observation group and control group by random number table method. The evaluation indicators included the treatment efficiency and the quality of life of the two groups. The results showed that the effective rate of the observation group was higher than that of the control group, and the difference between the two groups was statistically significant (P < 0.05). The experiment proves that the clinical effect of neurological nursing on cerebral apoplexy rehabilitation nursing is positive, which can improve the limb movement and self-living ability of patients, improve the quality of life of patients and improve patient satisfaction. Clinical study of neurology nursing on cerebral apoplexy rehabilitation nursing is discussed in this paper, and the rehabilitation nursing method and formal standardized nursing process of this disease are standardized.

Amyloid precursor protein (APP) metabolism is central to Alzheimer's disease (AD) pathogenesis, but the key etiological driver remains elusive. Recent failures of clinical trials targeting amyloid-β (Aβ) peptides, the proteolytic fragments of amyloid precursor protein (APP) that are the main component of amyloid plaques, suggest that the proteostasis-disrupting, key pathogenic species remain to be identified. Previous studies suggest that APP C-terminal fragment (APP.C99) can cause disease in an Aβ-independent manner. The mechanism of APP.C99 pathogenesis is incompletely understood. We used Drosophila models expressing APP.C99 with the native ER-targeting signal of human APP, expressing full-length human APP only, or co-expressing full-length human APP and β-secretase (BACE), to investigate mechanisms of APP.C99 pathogenesis. Key findings are validated in mammalian cell culture models, mouse 5xFAD model, and postmortem AD patient brain materials. We find that ribosomes stall at the ER membrane during co-translational translocation of APP.C99, activating ribosome-associated quality control (RQC) to resolve ribosome collision and stalled translation. Stalled APP.C99 species with C-terminal extensions (CAT-tails) resulting from inadequate RQC are prone to aggregation, causing endolysosomal and autophagy defects and seeding the aggregation of amyloid β peptides, the main component of amyloid plaques. Genetically removing stalled and CAT-tailed APP.C99 rescued proteostasis failure, endolysosomal/autophagy dysfunction, neuromuscular degeneration, and cognitive deficits in AD models. Our finding of RQC factor deposition at the core of amyloid plaques from AD brains further supports the central role of defective RQC of ribosome collision and stalled translation in AD pathogenesis. These findings demonstrate that amyloid plaque formation is the consequence and manifestation of a deeper level proteostasis failure caused by inadequate RQC of translational stalling and the resultant aberrantly modified APP.C99 species, previously unrecognized etiological drivers of AD and newly discovered therapeutic targets.

To address the lack of reliable measurement methods for identifying wear mechanisms and predicting the state of mechanical seal tribo-parts, this study proposes a method for characterizing tribological behavior based on measuring face vibration acceleration. It aims to uncover the source mechanism of mechanical seal face vibration acceleration influenced by tribology and dynamic behavior. This research delves into the dynamic behavior characteristics and vibration acceleration of the mechanical seal stationary ring. We explored the variation pattern of face vibration acceleration root mean square (RMS) with rotation speed, sealing medium pressure, and face surface roughness. The results indicate that under constant medium pressure, an increase in rotation speed leads to a decrease in acceleration RMS and an increase in face temperature. Similarly, under constant rotation speed, an increase in medium pressure results in nonlinear changes in acceleration RMS, forming an "M" shape, along with an increase in face temperature. Furthermore, under conditions of constant medium pressure and rotation speed, an increase in the surface roughness of the rotating ring face corresponds to an increase in acceleration RMS and face temperature. Upon starting the mechanical seal, both acceleration RMS and temperature initially increase before decreasing, a trend consistent with the Stribeck curve. [ABSTRACT FROM AUTHOR]

Based on mortar composites with a low water–cement ratio, the effects of hybrid aramid fiber (AF), calcium sulfate whisker (CSW), and basalt fiber (BF) on their mechanical properties and wear resistance were studied, and the correlation between wear resistance and compressive strength are discussed. A microstructure analysis was conducted through scanning electron microscopy (SEM) and the nitrogen-adsorption method (BET). The research results show that compared with the control group, the compressive strength, flexural strength, and wear resistance of the hybrid AF, CSW, and BF mortar composites with a low water–cement ratio increased by up to 33.6%, 32%, and 40.8%, respectively; there is a certain linear trend between wear resistance and compressive strength, but the discreteness is large. The microstructure analysis shows that CSW, AF, and BF mainly dissipate energy through bonding, friction, mechanical interlocking with the mortar matrix, and their own pull out and fracture, thereby enhancing and toughening the mortar. A single doping of CSW and co-doping of CSW and AF can refine the pore structure of the mortar, making the mortar structure more compact. [ABSTRACT FROM AUTHOR]

Spring-energized seals demonstrate good sealing performance over a wide range of pressures and temperatures and can compensate for installation eccentricity, high-temperature aging, etc. However, as a contact seal, its polytetrafluoroethylene (PTFE) jacket material is easily worn during the rotation of the end face, which leads to a decline in sealing performance and, ultimately, seal failure. Based on the Archard wear model, a performance prediction model of the spring-energized seal was established by combining tests and numerical analyses. In order to improve the tribological performance of spring-energized seals made of PTFE, varied fillers were added to modify the PTFE, and the tribological and mechanical properties of PTFE composites with varied fillers were measured in experiments. Using a performance prediction model for spring-energized seals, the variation in the friction performance of seals made of these filled PTFEs during the operating cycle was analyzed. The results showed that the performance prediction model can accurately simulate this variation. After a certain amount of wear, the deviation between the simulated data and the experimental data was within ±5%. Compared with spring-energized seals made of pure PTFE, the friction torque of spring-energized seals made of GF/PTFE was reduced by 28.97% at most, and the friction torque reduction rate was lowered by 22.25%. [ABSTRACT FROM AUTHOR]

Low-heat Portland cement and ground granulated blast furnace slag are widely used for the preparation of hydraulic concrete. Nevertheless, the effect and mechanism of corrosion on low-heat Portland cement paste mixed with ground granulated blast furnace slag need to be further explored. This paper investigated the impact of ground granulated blast furnace slag on the calcium leaching of low-heat Portland cement paste by evaluating its mass loss, porosity, leaching depth, compressive strength, and Vickers hardness, and comparing it with the leaching performance of ordinary Portland cement paste. Furthermore, the phase composition and morphology of low-heat Portland cement paste containing ground granulated blast furnace slag were analyzed by X-ray diffraction, mercury intrusion porosimetry, and scanning electron microscopy. The results indicate that, after 180 days of soaking in ammonium chloride solution, the mass loss rate, growth rate of porosity, leaching depth, and compressive strength loss rate of low-heat Portland cement paste were 8.0%, 43.6%, 9.1 mm, and 27.7%, respectively, while those of ordinary Portland cement paste were 7.4%, 37.8%, 8.4 mm, and 30.1%, indicating that low-heat Portland cement paste is slightly more damaging than ordinary Portland cement. The addition of ground granulated blast furnace slag could significantly improve the leaching resistance of low-heat Portland cement. For instance, after adding 20% ground granulated blast furnace slag, the above test values were 2.4%, 28.5%, 5.6 mm, and 20.8%, respectively. The reason for this is that ground granulated blast furnace slag has the potential to reduce the porosity of low-heat Portland cement paste, and it can also undergo the secondary hydration reaction with its hydration product Ca(OH)2 to enhance the paste structure. Considering the cost performance, the suitable dosage of low-heat Portland cement paste for satisfactory leaching resistance is about 20%. [ABSTRACT FROM AUTHOR]

Background: Nonylphenol (NP) is widely recognized as a crucial environmental endocrine-disrupting chemical and persistent toxic substance. The remediation of NP-contaminated sites primarily relies on biological degradation. Compound microbial products, as opposed to pure strains, possess a greater variety of metabolic pathways and can thrive in a wider range of environmental conditions. This characteristic is believed to facilitate the synergistic degradation of pollutants. Limited research has been conducted to thoroughly examine the potential compatibility of compound microbial agents with indigenous microflora, their ability to function effectively in practical environments, their capacity to enhance the dissipation of NP, and their potential to improve soil physicochemical and biological characteristics. Methods: In order to efficiently eliminate NP in contaminated soil in an eco-friendly manner, a simulation study was conducted to investigate the impact of bioaugmentation using the functional compound microbial agent NP-M2 at varying concentrations (50 and 200 mg/L) on the dynamics of the soil microbial community. The treatments were set as follows: sterilized soil with 50 mg/kg NP (CK50) or 200 mg/kg NP (CK200); non-sterilized soil with 50 mg/kg NP (TU50) or 200 mg/kg NP (TU200); non-sterilized soil with the compound microbial agent NP-M2 at 50 mg/kg NP (J50) or 200 mg/kg NP (J200). Full-length 16S rRNA analysis was performed using the PacBio Sequel II platform. Results: Both the indigenous microbes (TU50 and TU200 treatments) and the application of NP-M2 (J50 and J200 treatments) exhibited rapid NP removal, with removal rates ranging from 93% to 99%. The application of NP-M2 further accelerated the degradation rate of NP for a subtle lag period. Although the different treatments had minimal impacts on the soil bacterial α-diversity, they significantly altered the β-diversity and composition of the bacterial community. The dominant phyla were Proteobacteria (35.54%–44.14%), Acidobacteria (13.55%–17.07%), Planctomycetes (10.78%–11.42%), Bacteroidetes (5.60%–10.74%), and Actinobacteria (6.44%–8.68%). The core species were Luteitalea_pratensis, Pyrinomonas_methylaliphatogenes, Fimbriiglobus_ruber, Longimicrobium_terrae, and Massilia_sp003590855. The bacterial community structure and taxon distribution in polluted soils were significantly influenced by the activities of soil catalase, sucrase, and polyphenol oxidase, which were identified as the major environmental factors. Notably, the concentration of NP and, to a lesser extent, the compound microbial agent NP-M2 were found to cause major shifts in the bacterial community. This study highlights the importance of conducting bioremediation experiments in conjunction with microbiome assessment to better understand the impact of bioaugmentation/biostimulation on the potential functions of complex microbial communities present in contaminated soils, which is essential for bioremediation success. [ABSTRACT FROM AUTHOR]