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Objective To explore the effect of ambient music on sleep quality and cognitive function of college students with neurotic personality tendency. Methods Thirty college students with neurotic personality tendency who majored in clinical medicine and had sleep problems with Pittsburgh sleep quality index (PSQI) ≥8 were recruited from a medical university during October 2021 and January 2022. They were randomly assigned into the control and test groups (n=15). The test group received a 30-minute ambient music intervention via a Bluetooth music box before bedtime, and the control group had no music playing in the Bluetooth music box. Both groups were intervened for 2 d. The parameters of sleep quality, including sleep onset latency (SOL), total sleep time (TST), sleep efficiency (SE), rapid eye movement (REM), non-rapid eye movement (NREM), and the indicators in cognitive function, such as fatigue induction paradigm, attention network test (ANT), N-back paradigm, were compared pre- and post-intervention in both groups. Results Compared to the control group, the SOL of NREM (N1), N2 and N3 [4.000 (3.000, 6.000) vs 10.000 (7.500, 12.000), P=0.003; 6.000 (5.500, 9.000) vs 12.500 (9.500, 17.500), P=0.006; 16.000 (13.000, 19.500) vs 34.500 (22.000, 46.000), P=0.002] were significantly shorter, and the total N3 duration (109.433±27.281 vs 85.233±23.426, P=0.018) was obviously longer in the test group. In terms of cognitive function, statistically higher ANT correct rate (98.333±1.247 vs 96.154± 2.851, P=0.016) was observed in the test group. Conclusion Ambient music can improve the sleep quality of college students with neurotic personality tendency by shortening SOL and prolonging total N3 duration, and then enhances their concentration levels.

Background Atrial fibrillation (AF) patients are prone to stroke and peripheral arterial embolism. Studying the pathogenesis of thrombosis formation in AF and providing effective interventions to reduce the risk is an important direction of clinical and basic research on AF. Objective To investigate the correlation of markers of inflammation and endothelial injury with thrombosis in the left atrium (LA) in AF patients. Methods Twenty-nine patients with valvular heart disease and 10 patients with coronary heart disease who underwent thoracotomy at the First Affiliated Hospital of Guangxi Medical University from July 2017 to December 2019 were selected, and divided into sinus rhythm group (15 cases) and AF group 〔24 cases, including 12 with left atrial appendage thrombus (LAAT), and 12 without LAAT〕 according to heart rhythm. General demographics were collected. Besides that, other data were also collected, including left atrial diameter (LAD) and left ventricular ejection fraction (LVEF), levels of protein kinase B (AKT), nuclear factor-κ B (NF-κ B), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), IL-8, tumor necrosis factor (TNF-α), endothelin-1 (ET-1), nitric oxide (NO), von Willebrand factor (VWF), intercellular adhesion molecule (ICAM-1) and vascular cell adhesion factor (VCAM-1) in the left atrial blood sample, and calculated thrombus area in patients with AF and LAAT. The relationships of LAD, LVEF, markers of inflammation and endothelial injury with calculated area of thrombus in AF with LAAT patients were analyzed by Pearson correlation. Results There were significant differences in LAD and LVEF between sinus rhythm patients and AF patients with or without LAAT (P0.05). AF patients without LAAT had higher levels of AKT, NF-κB, IL-8, ET-1, ICAM-1 and VCAM-1 and lower NO level in left atrium than patients with sinus rhythm (P0.05). The maximum area, minimum area, and average area of the left atrial appendage thrombus in AF patients with LAAT were 4.8 cm2, 1.67 cm2, and (3.48±0.83) cm2, respectively. Pearson correlation analysis showed LAD, LVEF, AKT, NF-κB, hs-CRP, IL-6, IL-8, TNF-α, ET-1, NO, vWF, ICAM-1, and VCAM-1 had no linear correlation with the area of thrombus in AF patients with LAAT (P>0.05) . Conclusion Increased levels of markers of inflammation and endothelial injury in left atrium were found in AF patients, which were even more higher when the patients also had LAAT. Detecting the markers of inflammation and endothelial injury in left atrium is helpful to evaluate the thrombus prevalence in AF patients.

Objective. Currently, the summaries of research on periodontal ligament stem cells (PDLSCs) are mainly reviews, and the systematic evaluation of all relevant studies is lacking. The aim of our study was to reveal the research status and developmental trends of PDLSCs using bibliometric analyses. Methods. Publications on PDLSC from 2004 to 2023 in the PubMed database were searched and then screened according to certain inclusion and exclusion criteria. Two researchers browsed the included papers and recorded information such as the research type and research model. The VOSviewer software was used to analyze the distribution of authors, journals, and institutions. The contents and directions of PDLSC research were summarized by analyzing high‐frequency keywords. The CiteSpace software was used to monitor burst words, determine hot factors, and indicate developmental trends. Results. During the past two decades, the number of studies on PDLSCs increased. China published the most related papers. The primary type of article was basic research. Among core journals, the Journal of Periodontal Research had the highest number of publications. The Fourth Military Medical University (China) was leading in the number of articles on PDLSCs. Research topics mainly included mechanism of periodontal diseases, tissue engineering and regeneration, biological characteristics of PDLSCs, and comparison with other stem cells. Infectious inflammation and mechanical stimulation were important pathological conditions and research topics. Conclusion. The research of PDLSCs is still in a rapid development stage. Our study provides new insights into the current research status and future trend in this field. [ABSTRACT FROM AUTHOR]

Purpose: With the increasing need for well-­-prepared and leading practitioners in the field of education as well as the renewed efforts to further distinguish the EdD from the PhD in higher education in recent years, the curriculum of EdD programs nationwide has been questioned and criticized for its disconnection from the needs of leading practitioners and schools. The primary purpose of this study is to examine the practical relevance of the coursework of EdD programs in PK-­12 school leadership. Methods: Three hundred and forty-two principals from California public schools, and 43 EdD program graduates and 38 doctoral faculty members from the California State University system participated in this study. A survey instrument developed on the basis of ISLLC 1996 and ISLLC 2008 was used to measure respondents' perceived importance of the knowledge, skills, and values for effective school leadership and the extent to which they were included in the EdD coursework. MANOVA and discriminant analysis were conducted to answer the specific research questions. Findings: Results indicate that the curriculum of the EdD leadership programs lacks practical relevance. In practice the EdD has not been differentiated from the PhD with respect to the coursework. Implications: The practical relevance of the coursework should be considered in the assessment and evaluation of the quality or effectiveness of an EdD program, and used to distinguish the EdD from the PhD. The findings add empirical evidence to the renewed debate over the distinction between the EdD and the PhD, and spur revitalization of the EdD.

Optimizing the design of the conformal cooling channel can increase the cooling rate of injection mold. The aim of this study was the problem of low cooling efficiency of injection mold for deep-cavity plastic parts under the conventional cooling channel. Based on the analysis of the heat transfer principle of the injection mold, a mathematical description of the cooling time of the conformal cooling channel was made. By designing orthogonal experiments and using simulation methods in the Autodesk Moldflow 2019 software, with the minimum cooling time of the mold as the optimization goal, experimental optimization was carried out for the three design variables of the channel, thereby obtaining the optimal combination of design variables for the conformal cooling channel. The conformal cooling channel layout was innovatively designed, and through computer simulation experiments, it was concluded that the conformal cooling channel adopted a series flat-head layout, which has the shortest cooling time and the fastest cooling rate. Metal additive manufacturing technology was used to complete the manufacturing of the mold insert with the conformal cooling channel. After the trial production of the conformal cooling injection mold, the molding cycle was obviously shortened, and the injection molding production efficiency was significantly improved. [ABSTRACT FROM AUTHOR]

To study the relevant factors affecting corporate financial fraud and the interaction between factors, this paper extracts 19 factors affecting corporate financial fraud from 5 aspects. Then it divides the hierarchy using the interpretative structural modeling (ISM) respectively to clarify the logical relationships and calculate the values of dependency and driving force jointly with the Fuzzy MICMAC (MICMAC) to categorize the indicators affecting financial fraud. We found that: 6 indicators, such as profit and tax mismatch, are the key factors influencing corporate financial fraud and will directly lead to fraud; 6 indicators, such as income and long-term asset variation, have a high degree of correlation with other indicators and a wide range of influence on fraud; 7 indicators such as excessive managerial power, have a low probability of being influenced by other factors but have a higher probability of influencing other factors. Combining the research results with the actual situation, we finally provide suggestions for solving corporate financial fraud from 3 perspectives.

The application of livelihood resilience theory to villages that have been resettled due to coal mining provides insights into the levels and impediments of livelihood resilience under different resettlement models. Such an exploration holds critical significance for enhancing the livelihood resilience of the resettled households and promoting sustainable development in coal mining areas. Grounded in the theoretical framework of livelihood resilience and considering the realities of mining areas, by referring to existing studies, this study devises an evaluative index system. Utilizing the TOPSIS model to calculate the level of livelihood resilience, and we delve into the impediments to livelihood resilience of households that resettled under different models using the obstacle model. The results indicate the following: (1) Overall, the level of livelihood resilience in areas resettled due to coal mining of Huaibei City is low. Significant disparities exist among the households resettled under different models in terms of buffering capacity, self-organizing ability, and learning ability. (2) Factors such as the quantity of labor, policy awareness, and participation in village collective meetings significantly influence households' livelihood resilience, albeit to varying degrees across different resettlement models. (3) Future interventions should address the challenges faced by the four types of resettled households by increasing employment opportunities, intensifying policy advocacy, and augmenting investments in education resources to elevate the livelihood standards of various households. [ABSTRACT FROM AUTHOR]