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5. Therapeutic Strategies for COVID-19 Lung Disease in Children

Author

Gatti, Elisabetta, primary, Piotto, Marta, additional, Lelii, Mara, additional, Pensabene, Mariacarola, additional, Madini, Barbara, additional, Cerrato, Lucia, additional, Hassan, Vittoria, additional, Aliberti, Stefano, additional, Bosis, Samantha, additional, Marchisio, Paola, additional, and Patria, Maria Francesca, additional

Published
2022
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6. Can Asymptomatic or Non-Severe SARS-CoV-2 Infection Cause Medium-Term Pulmonary Sequelae in Children?

Author

Bottino, Ilaria, primary, Patria, Maria F., additional, Milani, Gregorio P., additional, Agostoni, Carlo, additional, Marchisio, Paola, additional, Lelii, Mara, additional, Alberzoni, Marco, additional, Dell'Era, Laura, additional, Castellazzi, Massimo L., additional, Senatore, Laura, additional, Madini, Barbara, additional, Pensabene, Maria C., additional, and Rocchi, Alessia, additional

Published
2021
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7. Familial Sleep Disorders in Unknown Genetic Syndrome

Author

Lelii, Mara, additional, Baggi, Elena, additional, Senatore, Laura, additional, Bedeschi, Maria Francesca, additional, Dilena, Robertino, additional, Iascone, Maria, additional, Gangi, Silvana, additional, Marchisio, Paola, additional, and Patria, Maria Francesca, additional

Published
2019
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14. Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine

Author

Esposito, Susanna, primary, Terranova, Leonardo, additional, Patria, Maria Francesca, additional, Marseglia, Gian Luigi, additional, Miraglia del Giudice, Michele, additional, Bodini, Alessandro, additional, Martelli, Alberto, additional, Baraldi, Eugenio, additional, Mazzina, Oscar, additional, Tagliabue, Claudia, additional, Licari, Amelia, additional, Ierardi, Valentina, additional, Lelii, Mara, additional, and Principi, Nicola, additional

Published
2015
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20. Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine.

Author

Esposito, Susanna, Terranova, Leonardo, Patria, Maria Francesca, Marseglia, Gian Luigi, del Giudice, Michele Miraglia, Bodini, Alessandro, Martelli, Alberto, Baraldi, Eugenio, Mazzina, Oscar, Tagliabue, Claudia, Licari, Amelia, Ierardi, Valentina, Lelii, Mara, Principi, Nicola, and Miraglia Del Giudice, Michele

Subjects
STREPTOCOCCUS pneumoniae, ASTHMA in children, PNEUMOCOCCAL vaccines, RESPIRATORY diseases, CHRONIC diseases, LUNG diseases, BACTERIAL colonies, ASTHMA prevention, NASOPHARYNX microbiology, STREPTOCOCCAL disease prevention, ASTHMA, CLINICAL trials, COMPARATIVE studies, CLINICAL drug trials, RESEARCH methodology, MEDICAL cooperation, RESEARCH, STREPTOCOCCAL diseases, STREPTOCOCCUS, VACCINES, EVALUATION research, PHYSIOLOGY
Abstract

Background: The main aim of this study was to evaluate Streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pneumococcal disease (IPD) of such patients and the potential protective efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13).Methods: Oropharyngeal samples were obtained from 423 children with documented asthma (300 males, 70.9%), and tested for the autolysin-A-encoding (lytA) and the wzg (cpsA) gene of S. pneumoniae by means of real-time polymerase chain reaction.Results: S. pneumoniae was identified in the swabs of 192 subjects (45.4%): 48.4% of whom were aged <10 years, 46.9% aged 10-14 years, and 4.7% aged ≥15 years (p < 0.001). Carriage was significantly less frequent among the children who had received recent antibiotic therapy (odds ratio [OR 0.41]; 95% confidence interval [95% CI] 0.22-0.76). Multivariate analyses showed no association between carriage and vaccination status, with ORs of 1.05 (95% CI 0.70-1.58) for carriers of any pneumococcal serotype, 1.08 (95% CI 0.72-1.62) for carriers of any of the serotypes included in 7-valent pneumococcal conjugate vaccine (PCV7), and 0.76 (95% CI 0.45-1.28) for carriers of any of the six additional serotypes of PCV13. Serotypes 19 F, 4 and 9 V were the most frequently identified serotypes in vaccinated subjects.Conclusions: These results showed that carriage of S. pneumoniae is relatively common in all school-aged children and adolescents with asthma, regardless of the severity of disease and the administration of PCV7 in the first years of life. This highlights the problem of the duration of the protection against colonisation provided by pneumococcal conjugate vaccine, and the importance of re-colonization by the same pneumococcal serotypes included in the previously used vaccine. [ABSTRACT FROM AUTHOR]

Published
2016
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21. Streptococcus pneumoniae colonisation in children and adolescents with asthma: Impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine

Author

Mara Lelii, Oscar Mazzina, Eugenio Baraldi, Gian Luigi Marseglia, Susanna Esposito, Arabella Martelli, Alessandro Bodini, Maria Francesca Patria, Valentina Ierardi, Michele Miraglia Del Giudice, Leonardo Terranova, Amelia Licari, Nicola Principi, Claudia Tagliabue, Esposito, Susanna, Terranova, Leonardo, Patria, Maria Francesca, Marseglia, Gian Luigi, MIRAGLIA DEL GIUDICE, Michele, Bodini, Alessandro, Martelli, Alberto, Baraldi, Eugenio, Mazzina, Oscar, Tagliabue, Claudia, Licari, Amelia, Ierardi, Valentina, Lelii, Mara, and Principi, Nicola

Subjects
0301 basic medicine, Male, Heptavalent Pneumococcal Conjugate Vaccine, PCV13, medicine.disease_cause, Pneumococcal conjugate vaccine, Asthma, Asthmatic children, Chronic respiratory disease, PCV7, Pneumococcal colonisation, Pulmonary disease, Streptococcus pneumoniae, Infectious Diseases, 0302 clinical medicine, Medical microbiology, vaccine, Nasopharynx, 030212 general & internal medicine, Child, Streptococcus, Pneumococcal infections, Child, Preschool, Female, Research Article, medicine.drug, Human, medicine.medical_specialty, Adolescent, Pneumococcal Infection, Pneumococcal Infections, 03 medical and health sciences, medicine, Humans, Vaccines, Conjugate, business.industry, medicine.disease, Streptococcus, asthma, vaccine, 030104 developmental biology, Carriage, Immunology, Drug Evaluation, business
Abstract

Background The main aim of this study was to evaluate Streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pneumococcal disease (IPD) of such patients and the potential protective efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods Oropharyngeal samples were obtained from 423 children with documented asthma (300 males, 70.9 %), and tested for the autolysin-A-encoding (lytA) and the wzg (cpsA) gene of S. pneumoniae by means of real-time polymerase chain reaction. Results S. pneumoniae was identified in the swabs of 192 subjects (45.4 %): 48.4 % of whom were aged

Published
2016

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