1. A LONG-RANGE RESTRICTION MAP OF HUMAN CHROMOSOME-5Q21-Q23
- Author
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J.R.Tristan Ward, Sally Cottrell, Huw J.W. Thomas, Tania A. Jones, Cathy M. Howe, Garret M. Hampton, Larry Deaven, Denise Sheer, Walter F. Bodmer, Ellen Solomon, and Anna-Maria Frischauf
- Subjects
Genetic Markers ,Genetics ,biology ,Gene map ,Genome, Human ,Adenomatous polyposis coli ,Hybridization probe ,Restriction Mapping ,Chromosome ,Cosmids ,Restriction map ,Adenomatous Polyposis Coli ,Gene mapping ,Genetic marker ,biology.protein ,Chromosomes, Human, Pair 5 ,Humans ,Chromosomes, Fungal ,DNA Probes ,Gene ,In Situ Hybridization, Fluorescence ,Polymorphism, Restriction Fragment Length ,Gene Library - Abstract
A long-range restriction map encompassing the APC (adenomatous polyposis coli) gene has been constructed. The map includes 35 DNA markers and consists of two segments of 10 and 2.5 Mb. Published genetic markers have been connected using additional, nonpolymorphic DNA probes. The map clarifies marker order and allows comparison of physical and genetic data.