Search

Your search keyword '"Lange, E."' showing total 635 results
Start Over Author "Lange, E." Search Limiters Full Text
635 results on '"Lange, E."'

3. Citizen science shows that small agricultural streams in Germany are in a poor ecological status

Author

von Gönner, Julia, Gröning, Jonas, Grescho, Volker, Neuer, L., Gottfried, B., Hänsch, V.G., Molsberger-Lange, E., Wilharm, E., Liess, Matthias, Bonn, Aletta, von Gönner, Julia, Gröning, Jonas, Grescho, Volker, Neuer, L., Gottfried, B., Hänsch, V.G., Molsberger-Lange, E., Wilharm, E., Liess, Matthias, and Bonn, Aletta

Abstract

Agricultural pesticides, nutrients, and habitat degradation are major causes of insect declines in lowland streams. To effectively conserve and restore stream habitats, standardized stream monitoring data and societal support for freshwater protection are needed. Here, we sampled 137 small stream monitoring sites across Germany, 83 % of which were located in agricultural catchments, with >900 citizen scientists in 96 monitoring groups. Sampling was carried out according to Water Framework Directive standards as part of the citizen science freshwater monitoring program FLOW in spring and summer 2021, 2022 and 2023. The biological indicator SPEARpesticides was used to assess pesticide exposure and effects based on macroinvertebrate community composition. Overall, 58 % of the agricultural monitoring sites failed to achieve a good ecological status in terms of macroinvertebrate community composition and indicated high pesticide exposure (SPEARpesticides status class: 29 % “moderate”, 19 % “poor”, 11 % “bad”). The indicated pesticide pressure in streams was related to the proportion of arable land in the catchment areas (R2 = 0.23, p < 0.001). Also with regards to hydromorphology, monitoring results revealed that 65 % of the agricultural monitoring sites failed to reach a good status. The database produced by citizen science groups was characterized by a high degree of accuracy, as results obtained by citizen scientists and professionals were highly correlated for SPEARpesticides index (R2 = 0.79, p < 0.001) and hydromorphology index values (R2 = 0.72, p < 0.001). Such citizen-driven monitoring of the status of watercourses could play a crucial role in monitoring and implementing the objectives of the European Water Framework Directive, thus contributing to restoring and protecting freshwater ecosystems.

Published
2024

5. Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue

Author

Liu, MB, De Lange, E, Garfinkel, A, Weiss, JN, and Qu, Z

Subjects
Cardiovascular System & Hematology, Biomedical Engineering, Cardiorespiratory Medicine and Haematology
Abstract

Background Delayed afterdepolarizations (DADs) have been well characterized as arrhythmia triggers, but their role in generating a tissue substrate vulnerable to reentry is not well understood. Objective The purpose of this study was to test the hypothesis that random DADs can self-organize to generate both an arrhythmia trigger and a vulnerable substrate simultaneously in cardiac tissue as a result of gap junction coupling. Methods Computer simulations in 1-dimensional cable and 2-dimensional tissue models were performed. The cellular DAD amplitude was varied by changing the strength of sarcoplasmic reticulum calcium release. Random DAD latency and amplitude in different cells were simulated using gaussian distributions. Results Depending on the strength of spontaneous sarcoplasmic reticulum calcium release and other conditions, random DADs in cardiac tissue resulted in the following behaviors: (1) triggered activity (TA); (2) a vulnerable tissue substrate causing unidirectional conduction block and reentry by inactivating sodium channels; (3) both triggers and a vulnerable substrate simultaneously by generating TA in regions next to regions with subthreshold DADs susceptible to unidirectional conduction block and reentry. The probability of the latter 2 behaviors was enhanced by reduced sodium channel availability, reduced gap junction coupling, increased tissue heterogeneity, and less synchronous DAD latency. Conclusion DADs can self-organize in tissue to generate arrhythmia triggers, a vulnerable tissue substrate, and both simultaneously. Reduced sodium channel availability and gap junction coupling potentiate this mechanism of arrhythmias, which are relevant to a variety of heart disease conditions.

Published
2015

6. Dynamic Glass Transition in Two Dimensions

Author

Bayer, M., Brader, J., Ebert, F., Lange, E., Fuchs, M., Maret, G., Schilling, R., Sperl, M., and Wittmer, J. P.

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Statistical Mechanics
Abstract

The question about the existence of a structural glass transition in two dimensions is studied using mode coupling theory (MCT). We determine the explicit d-dependence of the memory functional of mode coupling for one-component systems. Applied to two dimensions we solve the MCT equations numerically for monodisperse hard discs. A dynamic glass transition is found at a critical packing fraction phi_c^{d=2} = 0.697 which is above phi_c^{d=3} = 0.516 by about 35%. phi^d_c scales approximately with phi^d_{\rm rcp} the value for random close packing, at least for d=2, 3. Quantities characterizing the local, cooperative 'cage motion' do not differ much for d=2 and d=3, and we e.g. find the Lindemann criterion for the localization length at the glass transition. The final relaxation obeys the superposition principle, collapsing remarkably well onto a Kohlrausch law. The d=2 MCT results are in qualitative agreement with existing results from MC and MD simulations. The mean squared displacements measured experimentally for a quasi-two-dimensional binary system of dipolar hard spheres can be described satisfactorily by MCT for monodisperse hard discs over four decades in time provided the experimental control parameter Gamma (which measures the strength of dipolar interactions) and the packing fraction phi are properly related to each other., Comment: 14 pages, 15 figures

Published
2007
Full Text
View/download PDF

7. Randomized phase-II trial evaluating induction therapy with idarubicin and etoposide plus sequential or concurrent azacitidine and maintenance therapy with azacitidine

Author

Schlenk, R. F., Weber, D., Herr, W., Wulf, G., Salih, H. R., Derigs, H. G., Kuendgen, A., Ringhoffer, M., Hertenstein, B., Martens, U. M., Grießhammer, M., Bernhard, H., Krauter, J., Girschikofsky, M., Wolf, D., Lange, E., Westermann, J., Koller, E., Kremers, S., Wattad, M., Heuser, M., Thol, F., Göhring, G., Haase, D., Teleanu, V., Gaidzik, V., Benner, A., Döhner, K., Ganser, A., Paschka, P., and Döhner, H.

Published
2019
Full Text
View/download PDF

8. Landau Theory of the Finite Temperature Mott Transition

Author

Kotliar, G., Lange, E., and Rozenberg, M. J.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

In the context of the dynamical mean-field theory of the Hubbard model, we identify microscopically an order parameter for the finite temperature Mott endpoint. We derive a Landau functional of the order parameter. We then use the order parameter theory to elucidate the singular behavior of various physical quantities which are experimentally accessible., Comment: 4 pages, 2 figures

Published
2000
Full Text
View/download PDF

9. Two-scale analysis of the SU(N) Kondo Model

Author

Villani, D., Lange, E., Avella, A., and Kotliar, G.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We show how to resolve coherent low-energy features embedded in a broad high-energy background by use of a fully self-consistent calculation for composite particle operators. The method generalizes the formulation of Roth, which linearizes the dynamics of composite operators at any energy scale. Self-consistent equations are derived and analyzed in the case of the single-impurity SU(N) Kondo model., Comment: 4 RevTeX pages, 3 embedded EPS figures

Published
1999
Full Text
View/download PDF

10. Eye blinking, musical processing, and subjective states—A methods account (Earlly view)

Author

Lange, E., https://orcid.org/0000-0002-8928-3718, Fink, L., and https://orcid.org/0000-0001-6699-750X

Abstract

Affective sciences often make use of self-reports to assess subjective states. Seeking a more implicit measure for states and emotions, our study explored spontaneous eye blinking during music listening. However, blinking is understudied in the context of research on subjective states. Therefore, a second goal was to explore different ways of analyzing blink activity recorded from infra-red eye trackers, using two additional data sets from earlier studies differing in blinking and viewing instructions. We first replicate the effect of increased blink rates during music listening in comparison with silence and show that the effect is not related to changes in self-reported valence, arousal, or to specific musical features. Interestingly, but in contrast, felt absorption reduced participants' blinking. The instruction to inhibit blinking did not change results. From a methodological perspective, we make suggestions about how to define blinks from data loss periods recorded by eye trackers and report a data-driven outlier rejection procedure and its efficiency for subject-mean analyses, as well as trial-based analyses. We ran a variety of mixed effects models that differed in how trials without blinking were treated. The main results largely converged across accounts. The broad consistency of results across different experiments, outlier treatments, and statistical models demonstrates the reliability of the reported effects. As recordings of data loss periods come for free when interested in eye movements or pupillometry, we encourage researchers to pay attention to blink activity and contribute to the further understanding of the relation between blinking, subjective states, and cognitive processing.

Published
2023

15. The Influence of Socio-Demographic Factors on Preference and Park Usage in Guangzhou, China

Author

Ma, Y., Brindley, P., and Lange, E.

Subjects
Global and Planetary Change, Ecology, park usage, demographic difference, visiting preference, structured questionnaire survey, statistical analysis, Nature and Landscape Conservation
Abstract

Urban green space (UGS) provides a range of services to visitors and is particularly important for recreation and well-being. There are a number of approaches to research visitor accessibility, but implications for demographic differences of users are typically ignored. In order to more precisely model usage of UGS regarding visitor preference, this study used Guangzhou (China) as a case study, concentrating on residents’ visitation to parks and their factors across different groups (for example, by gender, education level, age and visiting frequency). Online questionnaires from 2360 adults were collected on visiting preferences, such as traveling time, visiting frequency, visit duration within parks, visiting reasons and barriers. Results indicate that women were less likely than men to undertake longer walking trips to access parks (over 40 min). Elderly people tended to have longer visit durations, and lower-educated people tended to have shorter visiting times (particularly less than 15 min) in parks. Visit duration in parks had a positive association with walking time and a negative association with visiting frequency. Furthermore, the proportion of people visiting parks to relieve stress declined with increasing age. Infrequent park users (visiting parks less than once a month) rarely visited to gain inspiration or to socialize with strangers. Barriers to use of parks were correlated with socio-demographic factors, highlighting that older people identified poor quality of parks and long walking times as critical barriers. This study provides evidence that there is no one-size-fits-all modeling approach for UGS usage; instead, it demonstrates the importance of considering the socio-demographic characteristics of users.

Published
2022
Full Text
View/download PDF

16. Outside (r) Fetishisms

Author

Lange, Elena Louisa, Pickett-Depaolis, Joshua, Lange, E L ( Elena Louisa ), Pickett-Depaolis, J ( Joshua ), Steineck, Raji; https://orcid.org/0000-0002-0407-5697, Lange, Elena Louisa, Pickett-Depaolis, Joshua, Lange, E L ( Elena Louisa ), Pickett-Depaolis, J ( Joshua ), and Steineck, Raji; https://orcid.org/0000-0002-0407-5697

Published
2022

17. Outside(r) fetishisms: Pathologies of Displaced Critique

Author

Lange, Elena L; https://orcid.org/0000-0002-8275-6869, Pickett-Depaolis, Joshua, Lange, E L ( Elena L ), Pickett-Depaolis, J ( Joshua ), Steineck, Raji; https://orcid.org/0000-0002-0407-5697, Lange, Elena L; https://orcid.org/0000-0002-8275-6869, Pickett-Depaolis, Joshua, Lange, E L ( Elena L ), Pickett-Depaolis, J ( Joshua ), and Steineck, Raji; https://orcid.org/0000-0002-0407-5697

Published
2022

18. Systematic stepwise screening of new microbial antagonists for biological control of European canker

Author

Elena, G., Groenenboom-de Haas, B.H., Houwers, I., de Lange, E., Schnabel, S.K., Köhl, J., Elena, G., Groenenboom-de Haas, B.H., Houwers, I., de Lange, E., Schnabel, S.K., and Köhl, J.

Abstract

Neonectria ditissima is the causal agent of European canker. This pathogen causes cankers on apple branches and the main stem, which may lead to the loss of the whole tree. Chemical control is the essential component in disease management and no suitable biocontrol products are commercially available. This study aimed at selecting potential microbial antagonists against N. ditissima through a systematic stepwise screening program for the development of a new biocontrol product. A total of 520 potential candidates were isolated from apple branches showing canker symptoms. Important characteristics for application of Microbial Biological Control Agents were tested per each candidate: spore production, spore survival during storage, cold tolerance, drought tolerance and UV-B resistance. Isolates able to germinate and grow at human body temperature were excluded. A total of 252 candidates fulfilled the stablished criteria. All 520 candidates belonged to 44 different taxonomic groups, being the most abundant Alternaria spp. (22.2 %), Aureobasidium pullulans (16.1 %), Cladosporium spp. (9.5 %) and Fusarium spp. (9.0 %). Information on possible pathogenicity and toxicity for humans, animals, plants and the environment and on patents in biocontrol use was collected per each identified species. A total of 158 candidates belonging to species that did not show potential risks or patent conflicts were assessed by their antagonistic behaviour against N. ditissima in bioassays in planta. Each candidate was inoculated in ‘Elstar’ apple branches inoculated with N. ditissima 24 h before. Inoculated branches were incubated at 17 °C, 16 h light per day and RH > 90 %. After four weeks, canker symptom expression was visually assessed. The capacity of the candidates to reduce colonisation of N. ditissima in the branches was evaluated by quantifying N. ditissima DNA concentration using qPCR. Four candidates of Clonostachys rosea showed antagonistic properties; after four weeks of treatmen

Published
2022

20. Stakeholder characteristics and interactions in a participatory community renewal project : a case study of Pun Tong Wuyue village, Guangzhou

Author

Lu, X. and Lange, E.

Abstract

In community renewal, a thorough understanding of the characteristics of stakeholders and their interactions is essential for achieving community consensus and optimizing the renewal outcomes. Different from the descriptive approaches that are often used for stakeholder analysis in community renewal, this research systematically analyzes the dynamics of the stakeholder network in participatory planning using the case of the Pun Tong Wuyue Micro-renewal Project. Drawing on the influence-interest grid, actor-linkage matrix and statistical analysis, data are collected through ethnographic observations, surveys and semi-structured interviews. The research is divided into three steps: 1) A total of 145 participants were grouped in 14 stakeholder categories; 2) The characteristics, including the influence, interest and participation level of each stakeholder, were analyzed; 3) The communications and relationships between various stakeholder categories were examined. The results highlight the effectiveness of holding participatory activities and establishing common interests in building positive stakeholder relationships. They also show the importance of community planners and designers, clan representatives, relevant governmental departments, and news media in mobilizing information. The marginalization of the elderly, females, less educated people and other less influential social groups was revealed, calling for more inclusive participation. The findings are of significance for the implementation of future participatory community renewal practices.

Published
2021

22. Randomized clinical trial of selective decontamination of the digestive tract in elective colorectal cancer surgery (SELECT trial)

Author

Abis, G. S. A., Stockmann, H. B. A. C., Bonjer, H. J., van Veenendaal, N., van Doorn-Schepens, M. L. M., Budding, A. E., Wilschut, J. A., van Egmond, M., Oosterling, S. J., de Lange, E. S. M., Tuynman, J. B., e. Vandenbroucke-Grauls, C. M. J., C. Stockmann, H. B. A., van der Bij, G. J., de Korte, N., Acherman, Y. I. Z., den Boer, F. C., Sonneveld, D. J. A., Poort, L., e Vandenbroucke-Grauls, C. M. J., C Stockmann, H. B. A., VU University medical center, CCA - Cancer Treatment and quality of life, APH - Quality of Care, APH - Global Health, Surgery, Medical Microbiology and Infection Prevention, AGEM - Digestive immunity, AII - Infectious diseases, Epidemiology and Data Science, Molecular cell biology and Immunology, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer biology and immunology, and ACS - Microcirculation

Subjects
Male, musculoskeletal diseases, medicine.medical_specialty, Colectomies, Colorectal cancer, Cefazolin, 030230 surgery, Anastomosis, Risk Assessment, law.invention, Hospitals, University, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Reference Values, Preoperative Care, medicine, Humans, Surgical Wound Infection, Antibiotic prophylaxis, Colectomy, Decontamination, Aged, Netherlands, Academic Medical Centers, Analysis of Variance, business.industry, Anastomosis, Surgical, Perioperative, Antibiotic Prophylaxis, Middle Aged, Interim analysis, medicine.disease, Surgery, Treatment Outcome, Elective Surgical Procedures, Multivariate Analysis, Tobramycin, 030211 gastroenterology & hepatology, Female, business, Colorectal Neoplasms, medicine.drug, Follow-Up Studies
Abstract

Background Infectious complications and anastomotic leakage affect approximately 30 per cent of patients after colorectal cancer surgery. The aim of this multicentre randomized trial was to investigate whether selective decontamination of the digestive tract (SDD) reduces these complications of elective colorectal cancer surgery. Methods The effectiveness of SDD was evaluated in a multicentre, open-label RCT in six centres in the Netherlands. Patients with colorectal cancer scheduled for elective curative surgery with a primary anastomosis were eligible. Oral colistin, tobramycin and amphotericin B were administered to patients in the SDD group to decontaminate the digestive tract. Both treatment and control group received intravenous cefazolin and metronidazole for perioperative prophylaxis. Mechanical bowel preparation was given for left-sided colectomies, sigmoid and anterior resections. Anastomotic leakage was the primary outcome; infectious complications and mortality were secondary outcomes. Results The outcomes for 228 patients randomized to the SDD group and 227 randomized to the control group were analysed. The trial was stopped after interim analysis demonstrated that superiority was no longer attainable. Effective SDD was confirmed by interspace DNA profiling analysis of rectal swabs. Anastomotic leakage was observed in 14 patients (6·1 per cent) in the SDD group and in 22 patients (9·7 per cent) in the control group (odds ratio (OR) 0·61, 95 per cent c.i. 0·30 to 1·22). Fewer patients in the SDD group had one or more infectious complications than patients in the control group (14·9 versus 26·9 per cent respectively; OR 0·48, 0·30 to 0·76). Multivariable analysis indicated that SDD reduced the rate of infectious complications (OR 0·47, 0·29 to 0·76). Conclusion SDD reduces infectious complications after colorectal cancer resection but did not significantly reduce anastomotic leakage in this trial. Registration number: NCT01740947 (https://www.clinicaltrials.gov).

Published
2019

24. Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR–ABL1-positive acute lymphoblastic leukemia

Author

Pfeifer, H, Wassmann, B, Bethge, W, Dengler, J, Bornhäuser, M, Stadler, M, Beelen, D, Vucinic, V, Burmeister, T, Stelljes, M, Faul, C, Dreger, P, Kiani, A, Schäfer-Eckart, K, Schwerdtfeger, R, Lange, E, Kubuschok, B, Horst, H A, Gramatzki, M, Brück, P, Serve, H, Hoelzer, D, Gökbuget, N, and Ottmann, O G

Published
2013
Full Text
View/download PDF

25. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Author

Natarajan, P. (Pradeep), Pampana, A. (Akhil), Graham, S. E. (Sarah E.), Ruotsalainen, S. E. (Sanni E.), Perry, J. A. (James A.), de Vries, P. S. (Paul S.), Broome, J. G. (Jai G.), Pirruccello, J. P. (James P.), Honigbere, M. C. (Michael C.), Aragam, K. (Krishna), Wolford, B. (Brooke), Brody, J. A. (Jennifer A.), Antonacci-Fulton, L. (Lucinda), Arden, M. (Moscati), Aslibekyan, S. (Stella), Assimes, T. L. (Themistocles L.), Ballantyne, C. M. (Christie M.), Bielak, L. F. (Lawrence F.), Bisl, J. C. (Joshua C.), Cade, B. E. (Brian E.), Do, R. (Ron), Doddapaneni, H. (Harsha), Emery, L. S. (Leslie S.), Hung, Y.-J. (Yi-Jen), Irvin, M. R. (Marguerite R.), Khan, A. T. (Alyna T.), Lange, L. (Leslie), Lee, J. (Jiwon), Lemaitre, R. N. (Rozenn N.), Martin, L. W. (Lisa W.), Metcalf, G. (Ginger), Montasser, M. E. (May E.), Moon, J.-Y. (Jee-Young), Muzny, D. (Donna), Connell, J. R. (Jeffrey R. O.), Palmer, N. D. (Nicholette D.), Peralta, J. M. (Juan M.), Peyser, P. A. (Patricia A.), Stilp, A. M. (Adrienne M.), Tsai, M. (Michael), Wang, F. F. (Fei Fei), Weeks, D. E. (Daniel E.), Yanek, L. R. (Lisa R.), Wilson, J. G. (James G.), Abecasis, G. (Goncalo), Arnett, D. K. (Donna K.), Becker, L. C. (Lewis C.), Blangercy, J. (John), Boerwinkle, E. (Eric), Bowden, D. W. (Donald W.), Chang, Y.-C. (Yi-Cheng), Chen, Y. I. (Yii-Der, I), Choi, W. J. (Won Jung), Correa, A. (Adolfo), Curran, J. E. (Joanne E.), Daly, M. J. (Mark J.), DutcherE, S. K. (Susan K.), Ellinor, P. T. (Patrick T.), Fornage, M. (Myriam), Freedman, B. I. (Barry, I), Gabriel, S. (Stacey), Germer, S. (Soren), Gibbs, R. A. (Richard A.), He, J. (Jiang), Hveem, K. (Kristian), Jarvik, G. P. (Gail P.), Kaplan, R. C. (Robert C.), Kardia, S. L. (Sharon L. R.), Kennyn, E. (Eimear), Kim, R. W. (Ryan W.), Kooperberg, C. (Charles), Laurie, C. C. (Cathy C.), Lee, S. (Seonwook), Lloyd-Jones, D. M. (Don M.), Loos, R. J. (Ruth J. F.), Lubitz, S. A. (Steven A.), Mathias, R. A. (Rasika A.), Martinez, K. A. (Karine A. Viaud), McGarvey, S. T. (Stephen T.), Mitche, B. D. (Braxton D.), Nickerson, D. A. (Deborah A.), North, K. E. (Kari E.), Palotie, A. (Aarno), Park, C. J. (Cheol Joo), Psat, B. M. (Bruce M. Y.), Rao, D. C. (D. C.), Redline, S. (Susan), Reiner, A. P. (Alexander P.), Seo, D. (Daekwan), Seo, J.-S. (Jeong-Sun), Smith, A. V. (Albert, V), Tracy, R. P. (Russell P.), Kathiresan, S. (Sekar), Cupples, L. A. (L. Adrienne), Rotten, J. I. (Jerome, I), Morrison, A. C. (Alanna C.), Rich, S. S. (Stephen S.), Ripatti, S. (Samuli), Wilier, C. (Cristen), Peloso, G. M. (Gina M.), Vasan, R. S. (Ramachandran S.), Abe, N. (Namiko), Albert, C. (Christine), Almasy, L. (Laura), Alonso, A. (Alvaro), Ament, S. (Seth), Anderson, P. (Peter), Applebaum-Bowden, D. (Deborah), Arking, D. (Dan), Ashley-Koch, A. (Allison), Auer, P. (Paul), Avramopoulos, D. (Dimitrios), Barnard, J. (John), Barnes, K. (Kathleen), Barr, R. G. (R. Graham), Barron-Casella, E. (Emily), Beaty, T. (Terri), Becker, D. (Diane), Beer, R. (Rebecca), Begum, F. (Ferdouse), Beitelshees, A. (Amber), Benjamin, E. (Emelia), Bezerra, M. (Marcos), Bielak, L. (Larry), Blackwel, T. (Thomas), Bowler, R. (Russell), Broecke, U. (Ulrich), Bunting, K. (Karen), Burchard, E. (Esteban), Buth, E. (Erin), Cardwel, J. (Jonathan), Carty, C. (Cara), Casaburi, R. (Richard), Casella, J. (James), Chaffin, M. (Mark), Chang, C. (Christy), Chasman, D. (Daniel), Chavan, S. (Sameer), Chen, B.-J. (Bo-Juen), Chen, W.-M. (Wei-Min), Chol, M. (Michael), Choi, S. H. (Seung Hoan), Chuang, L.-M. (Lee-Ming), Chung, M. (Mina), Conomos, M. P. (Matthew P.), Cornell, E. (Elaine), Crapo, J. (James), Curtis, J. (Jeffrey), Custer, B. (Brian), Damcott, C. (Coleen), Darbar, D. (Dawood), Das, S. (Sayantan), David, S. (Sean), Davis, C. (Colleen), Daya, M. (Michelle), de Andrade, M. (Mariza), DeBaunuo, M. (Michael), Duan, Q. (Qing), Devine, R. D. (Ranjan Deka Dawn DeMeo Scott), Duggirala, Q. R. (Qing Ravi), Durda, J. P. (Jon Peter), Dutcher, S. (Susan), Eaton, C. (Charles), Ekunwe, L. (Lynette), Farber, C. (Charles), Farnaml, L. (Leanna), Fingerlin, T. (Tasha), Flickinger, M. (Matthew), Franceschini, N. (Nora), Fu, M. (Mao), Fullerton, S. M. (Stephanie M.), Fulton, L. (Lucinda), Gan, W. (Weiniu), Gao, Y. (Yan), Gass, M. (Margery), Ge, B. (Bruce), Geng, X. P. (Xiaoqi Priscilla), Gignoux, C. (Chris), Gladwin, M. (Mark), Glahn, D. (David), Gogarten, S. (Stephanie), Gong, D.-W. (Da-Wei), Goring, H. (Harald), Gu, C. C. (C. Charles), Guan, Y. (Yue), Guo, X. (Xiuqing), Haessler, J. (Jeff), Hall, M. (Michael), Harris, D. (Daniel), Hawle, N. Y. (Nicola Y.), Heavner, B. (Ben), Heckbert, S. (Susan), Hernandez, R. (Ryan), Herrington, D. (David), Hersh, C. (Craig), Hidalgo, B. (Bertha), Hixson, J. (James), Hokanson, J. (John), Hong, E. (Elliott), Hoth, K. (Karin), Hsiung, C. A. (Chao Agnes), Huston, H. (Haley), Hwu, C. M. (Chii Min), Jackson, R. (Rebecca), Jain, D. (Deepti), Jaquish, C. (Cashell), Jhun, M. A. (Min A.), Johnsen, J. (Jill), Johnson, A. (Andrew), Johnson, C. (Craig), Johnston, R. (Rich), Jones, K. (Kimberly), Kang, H. M. (Hyun Min), Kaufman, L. (Laura), Kell, S. Y. (Shannon Y.), Kessler, M. (Michael), Kinney, G. (Greg), Konkle, B. (Barbara), Kramer, H. (Holly), Krauter, S. (Stephanie), Lange, C. (Christoph), Lange, E. (Ethan), Laurie, C. (Cecelia), LeBoff, M. (Meryl), Lee, S. S. (Seunggeun Shawn), Lee, W.-J. (Wen-Jane), LeFaive, J. (Jonathon), Levine, D. (David), Levy, D. (Dan), Lewis, J. (Joshua), Li, Y. (Yun), Lin, H. (Honghuang), Lin, K. H. (Keng Han), Lin, X. (Xihong), Liu, S. (Simin), Liu, Y. (Yongmei), Lunetta, K. (Kathryn), Luo, J. (James), Mahaney, M. (Michael), Make, B. (Barry), Manichaikul, A. (Ani), Mansonl, J. (JoAnn), Margolin, L. (Lauren), Mathai, S. (Susan), McArdle, P. (Patrick), Mcdonald, M.-L. (Merry-Lynn), McFarland, S. (Sean), McHugh, C. (Caitlin), Mei, H. (Hao), Meyers, D. A. (Deborah A.), Mikulla, J. (Julie), Min, N. (Nancy), Minear, M. (Mollie), Minster, R. L. (Ryan L.), Musani, S. (Solomon), Mwasongwe, S. (Stanford), Mychaleckyj, J. C. (Josyf C.), Nadkarni, G. (Girish), Naik, R. (Rakhi), Naseri, T. (Take), Nekhai, S. (Sergei), Nelson, S. C. (Sarah C.), Nickerson, D. (Deborah), Connell, J. O. (Jeff O.), Connor, T. O. (Tim O.), Ochs-Balcom, H. (Heather), Pankow, J. (James), Papanicolaou, G. (George), Parkerl, M. (Margaret), Parsa, A. (Afshin), Penchey, S. (Sara), Perez, M. (Marco), Peters, U. (Ulrike), Phillips, L. S. (Lawrence S.), Phillips, S. (Sam), Pollin, T. (Toni), Post, W. (Wendy), Becker, J. P. (Julia Powers), Boorgula, M. P. (Meher Preethi), Preuss, M. (Michael), Prokopenko, D. (Dmitry), Qasba, P. (Pankaj), Qiao, D. (Dandi), Rafaels, N. (Nicholas), Raffield, L. (Laura), Rasmussen-Torvik, L. (Laura), Ratan, A. (Aakrosh), Reed, R. (Robert), Reganl, E. (Elizabeth), Reupena, M. S. (Muagututi Sefuiva), Rice, K. (Ken), Roden, D. (Dan), Roselli, C. (Carolina), Ruczinski, I. (Ingo), Russel, P. (Pamela), Ruuska, S. (Sarah), Ryan, K. (Kathleen), Sabino, E. C. (Ester Cerdeira), Sakornsakolpatl, P. (Phuwanat), Salzberg, S. (Steven), Sandow, K. (Kevin), Sankaran, V. G. (Vijay G.), Scheller, C. (Christopher), Schmidt, E. (Ellen), Schwander, K. (Karen), Schwartz, D. (David), Sciurba, F. (Frank), Seidman, C. (Christine), Seidman, J. (Jonathan), Sheehan, V. (Vivien), Shetty, A. (Amol), Shetty, A. (Aniket), Sheu, W. H. (Wayne Hui-Heng), Shoemaker, M. B. (M. Benjamin), Silver, B. (Brian), Silvermanl, E. (Edwin), Smith, J. (Jennifer), Smith, J. (Josh), Smith, N. (Nicholas), Smith, T. (Tanja), Smoller, S. (Sylvia), Snively, B. (Beverly), Soferlm, T. (Tamar), Streeten, E. (Elizabeth), Su, J. L. (Jessica Lasky), Sung, Y. J. (Yun Ju), Sylvia, J. (Jody), Sztalryd, C. (Carole), Taliun, D. (Daniel), Tang, H. (Hua), Taub, M. (Margaret), Taylor, K. D. (Kent D.), Taylor, S. (Simeon), Telen, M. (Marilyn), Thornton, T. A. (Timothy A.), Tinker, L. (Lesley), Tirschwel, D. (David), Tiwari, H. (Hemant), Vaidya, D. (Dhananjay), VandeHaar, P. (Peter), Vrieze, S. (Scott), Walker, T. (Tarik), Wallace, R. (Robert), Waits, A. (Avram), Wan, E. (Emily), Wang, H. (Heming), Watson, K. (Karol), Weir, B. (Bruce), Weiss, S. (Scott), Weng, L.-C. (Lu-Chen), Williams, K. (Kayleen), Williams, L. K. (L. Keoki), Wilson, C. (Carla), Wong, Q. (Quenna), Xu, H. (Huichun), Yang, I. (Ivana), Yang, R. (Rongze), Zaghlou, N. (Norann), Zekavat, M. (Maryam), Zhang, Y. (Yingze), Zhao, S. X. (Snow Xueyan), Zhao, W. (Wei), Zni, D. (Degui), Zhou, X. (Xiang), Zhu, X. (Xiaofeng), Zody, M. (Michael), Zoellner, S. (Sebastian), Daly, M. (Mark), Jacob, H. (Howard), Matakidou, A. (Athena), Runz, H. (Heiko), John, S. (Sally), Plenge, R. (Robert), McCarthy, M. (Mark), Hunkapiller, J. (Julie), Ehm, M. (Meg), Waterworth, D. (Dawn), Fox, C. (Caroline), Malarstig, A. (Anders), Klinger, K. (Kathy), Call, K. (Kathy), Mkel, T. (Tomi), Kaprio, J. (Jaakko), Virolainen, P. (Petri), Pulkki, K. (Kari), Kilpi, T. (Terhi), Perola, M. (Markus), Partanen, J. (Jukka), Pitkranta, A. (Anne), Kaarteenaho, R. (Riitta), Vainio, S. (Seppo), Savinainen, K. (Kimmo), Kosma, V.-M. (Veli-Matti), Kujala, U. (Urho), Tuovila, O. (Outi), Hendolin, M. (Minna), Pakkanen, R. (Raimo), Waring, J. (Jeff), Riley-Gillis, B. (Bridget), Liu, J. (Jimmy), Biswas, S. (Shameek), Diogo, D. (Dorothee), Marshall, C. (Catherine), Hu, X. (Xinli), Gossel, M. (Matthias), Schleutker, J. (Johanna), Arvas, M. (Mikko), Hinttala, R. (Reetta), Kettunen, J. (Johannes), Laaksonen, R. (Reijo), Mannermaa, A. (Arto), Paloneva, J. (Juha), Soininen, H. (Hilkka), Julkunen, V. (Valtteri), Remes, A. (Anne), Klviinen, R. (Reetta), Hiltunen, M. (Mikko), Peltola, J. (Jukka), Tienari, P. (Pentti), Rinne, J. (Juha), Ziemann, A. (Adam), Waring, J. (Jeffrey), Esmaeeli, S. (Sahar), Smaoui, N. (Nizar), Lehtonen, A. (Anne), Eaton, S. (Susan), Landenper, S. (Sanni), Michon, J. (John), Kerchner, G. (Geoff), Bowers, N. (Natalie), Teng, E. (Edmond), Eicher, J. (John), Mehta, V. (Vinay), Gormle, P. Y. (Padhraig Y.), Linden, K. (Kari), Whelan, C. (Christopher), Xu, F. (Fanli), Pulford, D. (David), Frkkil, M. (Martti), Pikkarainen, S. (Sampsa), Jussila, A. (Airi), Blomster, T. (Timo), Kiviniemi, M. (Mikko), Voutilainen, M. (Markku), Georgantas, B. (Bob), Heap, G. (Graham), Rahimov, F. (Fedik), Usiskin, K. (Keith), Maranville, J. (Joseph), Lu, T. (Tim), Oh, D. (Danny), Kalpala, K. (Kirsi), Miller, M. (Melissa), McCarthy, L. (Linda), Eklund, K. (Kari), Palomki, A. (Antti), Isomki, P. (Pia), Piri, L. (Laura), Kaipiainen-Seppnen, O. (Oili), Lertratanaku, A. (Apinya), Bing, D. C. (David Close Marla Hochfeld Nan), Gordillo, J. E. (Jorge Esparza), Mars, N. (Nina), Laitinen, T. (Tarja), Pelkonen, M. (Margit), Kauppi, P. (Paula), Kankaanranta, H. (Hannu), Harju, T. (Terttu), Greenberg, S. (Steven), Chen, H. (Hubert), Betts, J. (Jo), Ghosh, S. (Soumitra), Salomaa, V. (Veikko), Niiranen, T. (Teemu), Juonala, M. (Markus), Metsrinne, K. (Kaj), Khnen, M. (Mika), Junttila, J. (Juhani), Laakso, M. (Markku), Pihlajamki, J. (Jussi), Sinisalo, J. (Juha), Taskinen, M.-R. (Marja-Riitta), Tuomi, T. (Tiinamaija), Laukkanen, J. (Jari), Challis, B. (Ben), Peterson, A. (Andrew), Chu, A. (Audrey), Parkkinen, J. (Jaakko), Muslin, A. (Anthony), Joensuu, H. (Heikki), Meretoja, T. (Tuomo), Aaltonen, L. (Lauri), Auranen, A. (Annika), Karihtala, P. (Peeter), Kauppila, S. (Saila), Auvinen, P. (Pivi), Elenius, K. (Klaus), Popovic, R. (Relja), Schutzman, J. (Jennifer), Loboda, A. (Andrey), Chhibber, A. (Aparna), Lehtonen, H. (Heli), McDonough, S. (Stefan), Crohns, M. (Marika), Kulkarni, D. (Diptee), Kaarniranta, K. (Kai), Turunen, J. (Joni), Ollila, T. (Terhi), Seitsonen, S. (Sanna), Uusitalo, H. (Hannu), Aaltonen, V. (Vesa), Uusitalo-Jrvinen, H. (Hannele), Luodonp, M. (Marja), Hautala, N. (Nina), Strauss, E. (Erich), Chen, H. (Hao), Podgornaia, A. (Anna), Hoffman, J. (Joshua), Tasanen, K. (Kaisa), Huilaja, L. (Laura), Hannula-Jouppi, K. (Katariina), Salmi, T. (Teea), Peltonen, S. (Sirkku), Koulu, L. (Leena), Harvima, I. (Ilkka), Wu, Y. (Ying), Choy, D. (David), Jalanko, A. (Anu), Kajanne, R. (Risto), Lyhs, U. (Ulrike), Kaunisto, M. (Mari), Davis, J. W. (Justin Wade), Quarless, D. (Danjuma), Petrovski, S. (Slav), Chen, C.-Y. (Chia-Yen), Bronson, P. (Paola), Yang, R. (Robert), Chang, D. (Diana), Bhangale, T. (Tushar), Holzinger, E. (Emily), Wang, X. (Xulong), Chen, X. (Xing), Auro, K. (Kirsi), Wang, C. (Clarence), Xu, E. (Ethan), Auge, F. (Franck), Chatelain, C. (Clement), Kurki, M. (Mitja), Karjalainen, J. (Juha), Havulinna, A. (Aki), Palin, K. (Kimmo), Palta, P. (Priit), Parolo, P. D. (Pietro Della Briotta), Zhou, W. (Wei), Lemmel, S. (Susanna), Rivas, M. (Manuel), Harju, J. (Jarmo), Lehisto, A. (Arto), Ganna, A. (Andrea), Llorens, V. (Vincent), Karlsson, A. (Antti), Kristiansson, K. (Kati), Hyvrinen, K. (Kati), Ritari, J. (Jarmo), Wahlfors, T. (Tiina), Koskinen, M. (Miika), Pylkäs, K. (Katri), Kalaoja, M. (Marita), Karjalainen, M. (Minna), Mantere, T. (Tuomo), Kangasniemi, E. (Eeva), Heikkinen, S. (Sami), Laakkonen, E. (Eija), Kononen, J. (Juha), Loukola, A. (Anu), Laiho, P. (Pivi), Sistonen, T. (Tuuli), Kaiharju, E. (Essi), Laukkanen, M. (Markku), Jrvensivu, E. (Elina), Lhteenmki, S. (Sini), Mnnikk, L. (Lotta), Wong, R. (Regis), Mattsson, H. (Hannele), Hiekkalinna, T. (Tero), Jimnez, M. G. (Manuel Gonzlez), Donner, K. (Kati), Prn, K. (KaIle), Nunez-Fontarnau, J. (Javier), Kilpelinen, E. (Elina), Sipi, T. P. (Timo P.), Brein, G. (Georg), Dada, A. (Alexander), Awaisa, G. (Ghazal), Shcherban, A. (Anastasia), Sipil, T. (Tuomas), Laivuori, H. (Hannele), Kiiskinen, T. (Tuomo), Siirtola, H. (Harri), Tabuenca, J. G. (Javier Gracia), Kallio, L. (Lila), Soini, S. (Sirpa), Pitknen, K. (Kimmo), and Kuopio, T. (Teijo)

Subjects
Cardiovascular genetics, Genome-wide association studies
Abstract

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10−72), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls (P = 1.7 × 10−4), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls (P = 1.4 × 10−5). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids.

Published
2021

26. De blauwdruk van de Apartheid: Hoe de Tweede Boerenoorlog identiteit en rassenscheiding heeft vormgegeven in Zuid-Afrika

Author

Draaijer, T.H., Lange, E., de (Thesis Advisor), Draaijer, T.H., and Lange, E., de (Thesis Advisor)

Abstract

De Apartheid staat alom bekend als het symbool van de rassenscheiding in Zuid-Afrika, terwijl de Tweede Boerenoorlog zich veelal in de obscuriteit bevindt. Opvallend, aangezien de Tweede Boerenoorlog het fundament van het Apartheidsregime is en het conflict het hedendaagse Zuid-Afrika nog steeds beïnvloedt. Deze scriptie onderzoekt de invloed van de geweldsomslag in de Tweede Boerenoorlog op raciale en nationale identiteit in Zuid-Afrika van 1899 tot 1913, een onderwerp dat pas na het einde van het kolonialisme en de Apartheid is opgepakt door historici. Halverwege 1900 sloeg de Boerenoorlog om van een conventionele oorlog naar een guerrillaoorlog. Deze overgang in oorlogsvoering veranderde ook de geweldsvormen. De Engelse counter-guerrillatactieken met de verschroeide aarde, interneringskampen en blokhuizen hadden blijvende gevolgen voor de Boerse samenleving en resulteerden in het volledig tot wasdom komen van het Afrikanernationalisme. Tegelijkertijd emancipeerde de zwarte bevolking door de toenemende participatie in de guerrillafase en ontstond hieruit het zwart nationalisme. Om de Boeren na de oorlog te binden in een gezamenlijk bestuur, gebruikten de Engelsen het wit nationalisme als natievormingsinstrument. De door het guerrillageweld verhardde anti-Britse Afrikanernationalisme werd zo onklaar gemaakt, doordat de Engelsen inspeelden op de eeuwenoude Boerse angst voor zwarte dominantie. Uit dit beleid ontsproot steeds verdere segregatie en uiteindelijk het Apartheidsregime. Raciale en nationale identiteit raakten nog meer verweven in Zuid-Afrika en de grenslijn tussen wit en zwart verhardde, wat tot op de dag van vandaag doorwerkt.

Published
2021

28. Het International Criminal Court en political trials in de strafzaak tegen Kenia

Author

Lubbers, I., Lange, E. de (Thesis Advisor), Lubbers, I., and Lange, E. de (Thesis Advisor)

Abstract

In deze scriptie is onderzoek gedaan naar de strafzaak van het International Criminal Court (ICC) tegen Kenia, om zo uit te zoeken welke kenmerken van een political trial deze strafzaak vertoonde. De kenmerken zijn zowel in de totstandkoming van de aanklacht van het ICC als in het daadwerkelijke proces terug te zien. De strafzaak betrof de rol van de Keniaanse regering in het geweld na de verkiezingen. Tijdens het geweld na afloop van de verkiezingen van 2007 zouden er volgens het ICC ‘crimes against humanity’ in Kenia hebben plaatsgevonden. Het ICC klaagde de Keniaanse regering, in de strafzaak beschreven als de ‘Ocampo six’, aan voor moord, deportatie, het vervolgen van etnische groepen, verkrachting en andere vormen van seksueel geweld en andere misdaden tegen de menselijkheid. Aan de hand van een samengesteld kader waarin de acht criteria van Barbara Falk voor political trials leidend zijn, wordt in deze scriptie onderzocht welke kenmerken van een political trial de strafzaak vertoonde. De scriptie legt een uniek verband tussen een strafzaak van het ICC en de kenmerken van een political trial. Bovendien leert het ons meer over de rol van politiek in de werking van het ICC.

Published
2021

29. De Nederlandse besluitvorming rondom UNIFIL 1979-1985: De rol van morele overwegingen

Author

Oskam, W.D.F., de Lange, E. (Thesis Advisor), Oskam, W.D.F., and de Lange, E. (Thesis Advisor)

Abstract

In 1979 kreeg Nederland het verzoek om deel te nemen aan de United Nations Interim Force in Libanon (UNIFIL). De historiografie benoemt dat de Nederlandse staat voornamelijk op grond van politieke overwegingen rondom eigenbelang besloot om deel te nemen. In deze scriptie wordt onderzocht of ook morele overwegingen ten behoeve van de vrede en veiligheid van Libanon en haar inwoners een rol speelden bij de besluitvorming. Tijdens de initiële besluitvorming in januari 1979 komen vooral politieke argumenten naar voren die vrezen voor imagoschade van Nederland wanneer het verzoek tot deelname wordt afgewezen. Morele overwegingen over het belang van vrede in Libanon hebben een ondergeschikte rol. Deze morele overwegingen zijn meer op de voorgrond in juni en oktober 1982, toen de Nederlandse staat wederom moest beslissen over de toekomst van UNIFIL. Het belang van vrede in Libanon en de veiligheid van de lokale bevolking waren toen de voornaamste reden om de bijdrage aan UNIFIL niet stop te zetten. Deze scriptie toont aan dat morele overwegingen onderdeel waren van de besluitvorming rondom UNIFIL en naarmate de tijd vorderde steeds sterker op de voorgrond kwamen.

Published
2021

30. Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci

Author

Breeze, CE, Batorsky, A, Lee, MK, Szeto, MD, Xu, X, McCartney, DL, Jiang, R, Patki, A, Kramer, HJ, Eales, JM, Raffield, L, Lange, L, Lange, E, Durda, P, Liu, Y, Tracy, RP, van den Berg, D, Evans, KL, Kraus, WE, Shah, S, Tiwari, HK, Hou, L, Whitsel, EA, Jiang, X, Charchar, FJ, Baccarelli, AA, Rich, SS, Morris, AP, Irvin, MR, Arnett, DK, Hauser, ER, Rotter, JI, Correa, A, Hayward, C, Horvath, S, Marioni, RE, Tomaszewski, M, Beck, S, Berndt, SI, London, SJ, Mychaleckyj, JC, Franceschini, N, Breeze, CE, Batorsky, A, Lee, MK, Szeto, MD, Xu, X, McCartney, DL, Jiang, R, Patki, A, Kramer, HJ, Eales, JM, Raffield, L, Lange, L, Lange, E, Durda, P, Liu, Y, Tracy, RP, van den Berg, D, Evans, KL, Kraus, WE, Shah, S, Tiwari, HK, Hou, L, Whitsel, EA, Jiang, X, Charchar, FJ, Baccarelli, AA, Rich, SS, Morris, AP, Irvin, MR, Arnett, DK, Hauser, ER, Rotter, JI, Correa, A, Hayward, C, Horvath, S, Marioni, RE, Tomaszewski, M, Beck, S, Berndt, SI, London, SJ, Mychaleckyj, JC, and Franceschini, N

Abstract

BACKGROUND: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic and ethnic-specific differentially methylated positions (DMPs) associated with eGFR using an agnostic, genome-wide approach. METHODS: The study included up to 5428 participants from multi-ethnic studies for discovery and 8109 participants for replication. We tested the associations between whole blood DNAm and eGFR using beta values from Illumina 450K or EPIC arrays. Ethnicity-stratified analyses were performed using linear mixed models adjusting for age, sex, smoking, and study-specific and technical variables. Summary results were meta-analyzed within and across ethnicities. Findings were assessed using integrative epigenomics methods and pathway analyses. RESULTS: We identified 93 DMPs associated with eGFR at an FDR of 0.05 and replicated 13 and 1 DMPs across independent samples in trans-ethnic and African American meta-analyses, respectively. The study also validated 6 previously published DMPs. Identified DMPs showed significant overlap enrichment with DNase I hypersensitive sites in kidney tissue, sites associated with the expression of proximal genes, and transcription factor motifs and pathways associated with kidney tissue and kidney development. CONCLUSIONS: We uncovered trans-ethnic and ethnic-specific DMPs associated with eGFR, including DMPs enriched in regulatory elements in kidney tissue and pathways related to kidney development. These findings shed light on epigenetic mechanisms associated with kidney function, bridging the gap between population-specific eGFR-associated DNAm and tissue-specific regulatory context.

Published
2021

37. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x)

Author

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T., Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., M. C. Y., Ng, Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Marchiori, Allison, Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. -D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Galbany, J. C., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Di Angelantonio, E., Drenos, F., Du, M., Dube, M. -P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A. -E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H. -J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, O., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J. -H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jorgensen, M. E., Jorgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kahonen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimaki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K. -H., Lin, L. -A., Lin, X., Lind, L., Lindstrom, J., Linneberg, A., Liu, C. -T., Liu, D. J., Liu, Y., K. S., Lo, Lophatananon, A., Lotery, A. J., Loukola, A., Luan, J., Lubitz, S. A., Lyytikainen, L. -P., Mannisto, S., Marenne, G., Mazul, A. L., Mccarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Muller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njolstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Loohuis, L. M. O., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renstrom, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. -H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J. -C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tonjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Edwards, D. R. V., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Volker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N., Loos, R. J. F., Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T., Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Marchiori, Allison, Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. -D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Galbany, J. C., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Di Angelantonio, E., Drenos, F., Du, M., Dube, M. -P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A. -E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H. -J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, O., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J. -H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jorgensen, M. E., Jorgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kahonen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimaki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K. -H., Lin, L. -A., Lin, X., Lind, L., Lindstrom, J., Linneberg, A., Liu, C. -T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, J., Lubitz, S. A., Lyytikainen, L. -P., Mannisto, S., Marenne, G., Mazul, A. L., Mccarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Muller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njolstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Loohuis, L. M. O., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renstrom, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. -H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J. -C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tonjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Edwards, D. R. V., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Volker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N., and Loos, R. J. F.

Subjects
Publisher correction
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2019

40. Menacing Tides: Security, Piracy and Empire in the Nineteenth-century Mediterranean

Author

de Lange, E., Internationale en Politieke geschiedenis, OGKG - Internationale en Politieke geschiedenis, LS History of Intern. Rel. & Global Gov., de Graaf, Beatrice, and Hoffenaar, Jan

Subjects
Congress System, imperialism, piracy, international relations, Mediterranean Sea, Barbary corsairs, security, North Africa, Post-Napoleonic Europe
Abstract

The fight against piracy changed the face of the Mediterranean forever. Over the course of the nineteenth century, the repression of the so-called ‘Barbary pirates’ from the North African states of Algiers, Tunis and Tripoli inspired diplomatic interventions, destructive bombardments and unprecedented forms of military cooperation. It also opened the door to European imperial expansion and colonial rule on the Mediterranean’s southern shores. Menacing Tides explains why the fight against Mediterranean piracy began and uncovers the importance of security thinking to this repressive effort. Starting in 1815, when peace in Europe brought different states together in new projects of cooperation, this work analyses how perceptions of a piratical threat were turned into implemented policies and military campaigns. Menacing Tides draws from various archives and tells the stories of high-ranking diplomats, pirate captains, ruined merchants and unsuspecting tourists, clarifying how the Mediterranean Sea was turned into a space of security.

Published
2020

44. Walking The Thin Line Between War and Peace: Hybrid Threats and the Dutch Security Culture between 2009 and 2019

Author

Lammertse, L., de Lange, E. (Thesis Advisor), Lammertse, L., and de Lange, E. (Thesis Advisor)

Abstract

Hybrid tactics of war considerably impact the feeling and understanding of the individual, national and international security. This thesis identifies how the Netherlands had to adapt to these hybrid tactics of war by researching how a hybrid security culture concerning hybrid warfare took shape in the Netherlands between 2009 and 2019. To understand if the growing attention towards hybrid conflict did cause a change in the ways of doing security in the Netherlands, this research identifies the core characteristics of the Dutch security culture. The research shows how the perception of threats presented by Dutch media coverage and knowledge institutes, can be divided into three waves. These three waves represented the contemporary state of mind regarding hybrid threats. Securitization theory helps in explaining how the third wave marked the beginning of the centrality of the audience. Mary Kaldor’s framework of four ideal types of security cultures is tested against the Dutch situation. Interviews with Dutch security officers and examination of official announcements made by the House of Representatives show how the Netherlands adhere to a combination of a ‘geo-political’ security culture and a ‘liberal peace’ security culture. This outcome goes against Kaldor’s assumption of how hybrid warfare fits in a mixture of ‘geo-political’ and ‘new wars’ security cultures. The convergence of the security cultures ‘liberal peace’ and ‘geo-politics’ in the Dutch case, shows that the way of dealing with hybrid warfare, can be much more diverse than is stated in the security culture literature presented by Kaldor. Moreover, the Dutch case highlights new continuities concerning Cold War practices.

Published
2020

45. Law, Peace and Status: Brazil as a Middle Power during the Second Hague Peace Conference 1907

Author

Janssen, L.W., de Lange, E. (Thesis Advisor), Janssen, L.W., and de Lange, E. (Thesis Advisor)

Abstract

This thesis provides new insights into Brazil’s adoption of the principle of sovereign equality during the Second Hague Peace Conference of 1907. Thus far, historians have mostly remained unexplanatory in their narratives, while IR theorist have been unable to engage with the historical context and the primary sources. I combine historical research with a staunch theoretical analysis to provide an explanation for Brazil’s performance. First, we should understand Brazil as a middle power. In this thesis I develop a historical model for defining middle powers and work out the foreign policy strategies of these powers. Secondly, we should understand Brazil’s foreign policy as driven by status concerns. By doing extensive archival research and historical contextualisation, this thesis reveals the status-seeking motivations behind Brazil’s performance during the Conference. Next to improving our understanding of this case, the research also changes our understanding of middle powers, their role in the dynamics of the international order, and the theory behind middle powers. As such, the thesis also presents new ways for thinking about and analysing middle powers throughout history.

Published
2020

46. Timeless Racism: A Study of the Evolution of the Concept of Racism in the United Nations’ World Conferences Against Racism (1978-2001)

Author

Enden, J.S. van den, Lange, E. de (Thesis Advisor), Enden, J.S. van den, and Lange, E. de (Thesis Advisor)

Abstract

Advocacy against racism has been a principal element of the human rights mechanism of the United Nations ever since the Universal Declaration of Human Rights in 1948. This thesis examines the conceptualization of racism within two United Nations World Conferences Against Racism (1978 and 2001) that were designed within this mechanism and analyzes whether the conceptualization of racism changed between the two summits. The general claim of this thesis is that racism, as a highly normative concept, is directly influenced by historical socio-political developments, and concludes that the conferences in 1978 and 2001 each present a different approach to racism. In 1978, the concept of racism was deliberately shaped to support the United Nations' struggle against the social segregation policies in South Africa (apartheid). In 2001, however, the conference presented a much broader, and less implicit conceptualization of racism, as the conference was set in a period of transformation within the UN in regard to its human rights mechanism. With this comparative case-study, this thesis shows how socio-political currents, as well as the organization of the conference and the influence of individual delegations have the ability to cause significant fluctuations in the conceptualization and definition of racism, indicating that ideology within the framework of human rights is highly politicized and constantly shifting.

Published
2020

47. The repression of chaos: Legal, economic and cultural repression in the early Soviet Union

Author

Aarden, R.S., de Lange, E. (Thesis Advisor), Aarden, R.S., and de Lange, E. (Thesis Advisor)

Abstract

This thesis analyses the relation between the social context of the early Soviet Union and the repressive policies that were implemented. The Central Communist government made use of legal, economic and cultural repression with the intention of controlling Soviet society. The central argument in this thesis is that the instigation and intensification of repression was often related to a perceived or present sense of chaos or disorder. The Bolshevik party did not hold a position of unchallenged authority in the early years of the Soviet Union and often acted out of suspicion and paranoia. Social disorder was therefore referred to as a new form of class war, partly because it could jeopardize the power of the communist regime. By analyzing all these aspects of repression, this thesis will provide an answer to the question: How were different forms of repressive policy connected to the social context of the Soviet Union between 1917 and 1941? After social disorder was appointed the new class war, all individuals seen as threats to social order or the socialist ideal state were attacked with repressive measures. These threats encompassed a wide variety of different groups within Soviet society. Wealthier citizens, members of the old regime, petty thieves, other socialists, ethnic groups, religious believers and political opposers all became victims of the repressive policies. By eliminating these factors from Soviet society, the government hoped to create a unified socialist state that was under their complete control. The use of visual and textual propaganda aided the implementation of such policies. Campaigns were set out to rally support for initiatives such as collectivization or state atheism. The success of these policies was varied and differed depending on region and time. Throughout the years of the early Soviet Union, it does, however, become apparent that both legal and economic repression proved more successful in fulfilling the desired effect of the governm

Published
2020

48. Residual abdominal lymphadenopathy after intensive frontline chemoimmunotherapy is associated with inferior outcome independently of minimal residual disease status in chronic lymphocytic leukemia

Author

Fuerstenau, M., Bahlo, J., Fink, A. M., Lange, E., Dreger, P., Dreyling, M., Hess, G., Ritgen, M., Kneba, M., Doehner, H., Stilgenbauer, S., Wendtner, C. M., Goede, V., Fischer, K., Boettcher, S., Hallek, M., Eichhorst, B., Fuerstenau, M., Bahlo, J., Fink, A. M., Lange, E., Dreger, P., Dreyling, M., Hess, G., Ritgen, M., Kneba, M., Doehner, H., Stilgenbauer, S., Wendtner, C. M., Goede, V., Fischer, K., Boettcher, S., Hallek, M., and Eichhorst, B.

Published
2020

49. Menacing Tides: Security, Piracy and Empire in the Nineteenth-century Mediterranean

Author

Internationale en Politieke geschiedenis, OGKG - Internationale en Politieke geschiedenis, LS History of Intern. Rel. & Global Gov., de Graaf, Beatrice, Hoffenaar, Jan, de Lange, E., Internationale en Politieke geschiedenis, OGKG - Internationale en Politieke geschiedenis, LS History of Intern. Rel. & Global Gov., de Graaf, Beatrice, Hoffenaar, Jan, and de Lange, E.

Published
2020

50. Starten in de landbouw : De uitkomsten van het project Startersboerderij in beeld

Author

Baan, I., Bremmer, B., Dekker, D., Lange, E. de, Leeuwen, M. van, Raaij, C. van, Smeets, J., Baan, I., Bremmer, B., Dekker, D., Lange, E. de, Leeuwen, M. van, Raaij, C. van, and Smeets, J.

Abstract

In 2018 is in samenwerking met varkenshouder Dirk Dekker het project Startersboerderij gestart. Dekker maakt zich - als ondernemer zonder opvolger - hard voor nieuwkomers in de agrarische sector. Steeds meer burgers hebben de ambitie om een agrarisch bedrijf te runnen. Ze zijn innovatief, hebben een frisse blik en zorgen voor bedrijvigheid en werkgelegenheid op het platteland. De weg ernaartoe is er echter één van puzzelen en uitdagingen aangaan. Want boer of tuinder worden: hoe pak je dat aan? Gedurende het project Startersboerderij is gewerkt aan een verkenning van deze uitdagingen. Waarom is het zo lastig om als nieuwe boer toe te treden tot de agrarische sector? Wat hebben starters nodig om succesvol te kunnen starten? Welke oplossingen dragen zij zelf aan en wat is hiervoor nodig? Welke rol kunnen huidige boeren zonder opvolgers hierin spelen?

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results