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Your search keyword '"Lam, Wynnie Wai-man"' showing total 2 results
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2 results on '"Lam, Wynnie Wai-man"'

1. A cross-sectional magnetic resonance imaging assessment of organ specific hemosiderosis in 180 thalassemia major patients in Hong Kong.

Author

Au WY, Lam WW, Chu WW, Yuen HL, Ling AS, Li RC, Chan HM, Lee HK, Law MF, Liu HS, Liang R, and Ha SY

Subjects
Adolescent, Adult, Algorithms, Child, Female, Hematology methods, Hemosiderosis complications, Hemosiderosis ethnology, Hong Kong, Humans, Male, Middle Aged, Pancreas pathology, Pituitary Gland pathology, beta-Thalassemia complications, beta-Thalassemia ethnology, Hemosiderosis pathology, Magnetic Resonance Imaging methods, beta-Thalassemia pathology
Published
2008
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2. A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major.

Author

Au WY, Lam WW, Chu W, Tam S, Wong WK, Liang R, and Ha SY

Subjects
Adolescent, Adult, Chelating Agents pharmacology, Child, Female, Ferritins metabolism, Humans, Liver metabolism, Male, Middle Aged, Iron metabolism, Iron Overload diagnosis, Iron Overload pathology, Magnetic Resonance Imaging methods, Pancreas metabolism, Pancreas pathology, beta-Thalassemia metabolism, beta-Thalassemia pathology
Abstract

We studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI-T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (beta cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels. This suggested that improved chelation may improve beta cell reserve and prevent pancreatic atrophy.

Published
2008
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