326 results on '"Laine, Matti"'
Search Results
2. Fluctuations of Attention During Self-paced Naturalistic Goal-Directed Behavior in Attention-Deficit/Hyperactivity Disorder
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Salmi, Juha, Merzon, Liya, Eräste, Tilda, Seesjärvi, Erik, Huhdanpää, Hanna, Aronen, Eeva T., Mannerkoski, Minna, MacInnes, W. Joseph, and Laine, Matti
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- 2024
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3. Working memory training restores aberrant brain activity in adult attention-deficit hyperactivity disorder.
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Salmi, Juha, Soveri, Anna, Salmela, Viljami, Alho, Kimmo, Leppämäki, Sami, Tani, Pekka, Koski, Anniina, Jaeggi, Susanne, and Laine, Matti
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ADHD ,brain imaging ,cognitive training ,working memory ,Adult ,Attention Deficit Disorder with Hyperactivity ,Cerebellum ,Cerebral Cortex ,Cognitive Remediation ,Default Mode Network ,Executive Function ,Humans ,Magnetic Resonance Imaging ,Male ,Memory ,Short-Term ,Nerve Net ,Outcome Assessment ,Health Care ,Psychomotor Performance ,Young Adult - Abstract
The development of treatments for attention impairments is hampered by limited knowledge about the malleability of underlying neural functions. We conducted the first randomized controlled trial to determine the modulations of brain activity associated with working memory (WM) training in adults with attention-deficit hyperactivity disorder (ADHD). At baseline, we assessed the aberrant functional brain activity in the n-back WM task by comparing 44 adults with ADHD with 18 healthy controls using fMRI. Participants with ADHD were then randomized to train on an adaptive dual n-back task or an active control task. We tested whether WM training elicits redistribution of brain activity as observed in healthy controls, and whether it might further restore aberrant activity related to ADHD. As expected, activity in areas of the default-mode (DMN), salience (SN), sensory-motor (SMN), frontoparietal (FPN), and subcortical (SCN) networks was decreased in participants with ADHD at pretest as compared with healthy controls, especially when the cognitive load was high. WM training modulated widespread FPN and SN areas, restoring some of the aberrant activity. Training effects were mainly observed as decreased brain activity during the trained task and increased activity during the untrained task, suggesting different neural mechanisms for trained and transfer tasks.
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- 2020
4. Video gaming and working memory: A large-scale cross-sectional correlative study
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Waris, Otto, Jaeggi, Susanne M, Seitz, Aaron R, Lehtonen, Minna, Soveri, Anna, Lukasik, Karolina M, Söderström, Ulrika, Hoffing, Russell C, and Laine, Matti
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Psychology ,Applied and Developmental Psychology ,Behavioral and Social Science ,Basic Behavioral and Social Science ,Clinical Research ,Mental health ,Video game ,Working memory ,Cognition ,Playing time ,Self-report ,cognition ,playing time ,self-report ,video game ,working memory ,Information Systems ,Cognitive Sciences ,Education ,Human-centred computing ,Applied and developmental psychology ,Cognitive and computational psychology - Abstract
Studies have indicated that video gaming is positively associated with cognitive performance in select cognitive domains, but the magnitudes of these associations have been called into question, as they have frequently been based on extreme groups analyses that have compared video gamers with non-gamers. When including the whole range of participants, and not just extreme cases, these effects were observed to reduce markedly (Unsworth et al., 2015). To further study this issue, we compared the associations between video gaming and aspects of working memory (WM) performance in an extreme groups design to those of a design that includes the full range of participants in a large adult sample (n = 503). WM was measured with three composite scores (verbal WM, visuospatial WM, n-back). The extreme groups analyses showed that video gamers performed better than non-gamers on all three WM measures, while the whole sample analyses indicated weak positive associations between the time spent playing video games and visuospatial WM and n-back performance. Thus, study design modulated the effects, but two of the three associations between WM and video gaming were consistent across both analysis techniques. A separate study confirmed that our questionnaire-based estimate of gaming hours was reliable when compared with one-week diaries of videogame playing. While the present cross-sectional results preclude causal inferences, possible mechanisms of WM - videogame playing associations and future research directions are discussed. Overall, our results indicate that cognition - videogame playing relationships, albeit weak, are not solely due to recently discussed methodological artefacts concerning the particular analytical approach and survey reliability.
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- 2019
5. The Outcome after Endovascular and Open Repair of Abdominal Aortic Aneurysms—A Binational Study Conducted between 1998 and 2017.
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Pirinen, Riku, Laine, Matti T., Mani, Kevin, Gunnarsson, Kim, Wanhainen, Anders, Sund, Reijo, and Venermo, Maarit
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ENDOVASCULAR aneurysm repair , *ENDOVASCULAR surgery , *ABDOMINAL aortic aneurysms , *VASCULAR surgery , *AGE groups - Abstract
Objective: We aimed to analyse patient outcomes following open (OAR) or endovascular repair (EVAR) of an abdominal aortic aneurysm (AAA) in Finland and Sweden from 1998 to 2017. Both intact and ruptured AAAs (rAAAs) were included in the analysis. Methods: Patient-level data from national registries in Finland and Sweden were analysed, pairing operations for intact and ruptured AAA repair with mortality data (date of death). All-cause mortality was the primary endpoint. Anonymized patient data from both countries were pooled, comprising a total of 32,324 operations. Ruptured and intact AAAs were considered separately. In total, EVAR was performed on 9619 intact AAAs and 1470 rAAAs, while OAR was performed on 13,241 intact AAAs and 7994 rAAAs. The patient's age, sex and the date of operation were obtained as demographic information. Cox regression and Kaplan–Meier analyses were used to evaluate long-term (10-year) survival after the treatment of AAA or rAAA with either modality. Kaplan–Meier analysis was performed in three different age groups (<65 years, 65–79 years and ≥80 years). Results: Considering all age groups together, the 1-, 3- and 10-year Kaplan–Meier survival rates after EVAR were 93.4%, 80.5% and 35.3%, respectively, for intact AAA repair and 67.2%, 55.9% and 22.2%, respectively, for rAAA repair. For OAR of intact AAAs, the 1-, 3- and 10-year Kaplan–Meier survival rates were 92.1%, 84.8% and 48.7%, respectively. The respective rates for OAR of rAAAs were 55.4%, 49.3% and 24.6%. In a Cox regression analysis, a more recent year of operation was associated with improved survival, and older age affected survival negatively for both intact and ruptured AAA repair. If patients survived the first 90 days after the operation, the survival after intact AAA repair was 13.5 years for those <65 years (general population: 18.0 years), and 7.3 years for those ≥80 years (general population: 7.9 years). After rAAA repair, the mean survival was 13.1 years for patients <65 years and 5.5 years for patients ≥80 years, respectively. Conclusions: The long-term survival of patients undergoing intact AAA treatment at the age of 80 or older is close to that of the general population, provided they survive the operation. Conversely, for patients younger than 65, the long-term survival is markedly worse. The long-term survival of AAA patients has improved over time. Open surgery is still a safe and effective option for young patients undergoing intact AAA repair. Our results support the ESVS guidelines recommendation of EVAR being the first-line treatment for patients with rAAA. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study
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Ruffino, Maria Antonella, Chan, Sharon, Coughlin, Patrick, Awopetu, Ayoola, Stather, Philip, Lane, Tristan, Theodosiou, Dimitrios, Ahmed, Mohamed Abozeid, Vasudevan, Thodur, Ibrahim, Mohammed, Al Maadany, Faraj, Eljareh, Mohamed, Alkhafeefi, Fatimah Saad, Coscas, Raphael, Ünal, Ertekin Utku, Pulli, Raffaele, Zacà, Sergio, Angiletta, Domenico, Kotsis, Thomas, Moawad, Magdy, Tozzi, Matteo, Patelis, Nikolaos, Lazaris, Andreas M., Chuen, Jason, Croo, Alexander, Tsolaki, Elpiniki, Zenunaj, Gladiol, Kamal, Dhafer, Tolba, Mahmoud MH., Maresch, Martin, Khetarpaul, Vipul, Mills, Joseph, Gangwani, Gaurav, Elahwal, Mohamed, Khalil, Rana, Azab, Mohammed A., Mahomed, Anver, Whiston, Richard, Contractor, Ummul, Esposito, Davide, Pratesi, Carlo, Giacomelli, Elena, Troncoso, Martín Veras, Elkouri, Stephane, Johansson, Flavia Gentile, Dodos, Ilias, Benezit, Marie, Vidoedo, José, Rocha-Neves, João, Pereira-Neves, António Henrique, Dias-Neto, Marina Felicidade, Campos Jácome, Ana Filipa, Loureiro, Luis, Silva, Ivone, Garza-Herrera, Rodrigo, Canata, Victor, Bezard, Charlotte, Bowser, Kathryn, Tobar, Jorge Felipe, Vera, Carlos Gomez, Parra, Carolina Salinas, Lopez, Eugenia, Serra, Yvis Gadelha, Varela, Juan, Rubio, Vanessa, Victoria, Gerardo, Johnson, Adam, O’Banion, Leigh Ann, Makar, Ragai, Tantawy, Tamer Ghatwary, Storck, Martin, Jongkind, Vincent, falah, Orwa, McBride, Olivia, Isik, Arda, Papaioannou, Athanasios, Ocke Reis, Paulo Eduardo, Bracale, Umberto Marcello, Atkins, Ellie, Tinelli, Giovanni, Scott, Emma, Wales, Lucy, Sivaharan, Ashwin, Priona, Georgia, Nesbitt, Craig, Grainger, Tabitha, Shelmerdine, Lauren, Chong, Patrick, Bajwa, Adnan, Arwynck, Luke, Hadjievangelou, Nancy, Elbasty, Ahmed, Rubio, Oscar, Ricardo, Michael, Ulloa, Jorge H., Tarazona, Marcos, Pabon, Manuel, Pitoulias, Georgios, Corless, Kevin, Ioannidis, Orestis, Friedrich, Oliver, Van Herzeele, Isabelle, Vijaynagar, Badri, Cohnert, Tina, Bell, Rachel, Moore, Hayley, Saha, Prakash, Gifford, Edward, Laine, Matti, Barkat, Adel, Karkos, Christos, Binti Safri, Lenny Suryani, Buitron, Gabriel, Del Castillo, Javier, Carrera, Paul, Salinas, Nilson, Biagioni, Rodrigo Bruno, Benites, Sergio, Mafla, César Andrés, Pian, Putera Mas, Albino, Pereira, Serrano, Ernesto, Marin, Andres, González, Marco, Foreroga, Marsha, Russo, Alejandro, Reyes, Andrés, Guglielmone, Daniel, Grillo, Lorena, Flumignan, Ronald, Palones, Francisco Gomez, Silveira, Pierre Galvagni, Ramely, Rosnelifaizur Bin, Edeiken, Sara, Chetter, Ian, Green, Lucy, Sudarsanam, Abhilash, Lyons, Oliver, Lemmon, Gary, Neville, Richard, Castelli, Mariano, Hinojosa, Carlos A., Carvajal, Rubén Rodríguez, Rivera, Aksim, Wong, Peng, Drudi, Laura, Perkins, Jeremy, Sieunarine, Kishore, Attia, Doaa, Atef, Mahmoud, Eftychios, Lostoridis, Weaver, Fred, Ren, Leong Chuo, Alomari, Mohannad, Jamjoom, Reda, Aljarrah, Qusai, Abbas, Ayman, Alomran, Faris, Kumar, Ambrish, Altoijri, Abdulmajeed, ElSanhoury, Kareem T., Alhumaid, Ahmed, Fekry, Tamer, Sekhar, Raghuram, Theodoridis, Panagiotis, Panagiotis, Theodoridis, Roditis, Konstantinos, Tsiantoula, Paraskevi, Antoniou, Afroditi, Soler, Raphael, Hasemaki, Natasha, Baili, Efstratia, Mpaili, Eustratia, Huasen, Bella, Wallace, Tom, Duncan, Andrew, Metcalfe, Matthew, Mannoia, Kristyn, Bechara, Carlos F., Tsilimparis, Nikolaos, Aranson, Nathan, Riding, David, Palena, Mariano, McDonnell, Ciarán, Mouawad, Nicolas J., Banegas, Shonda, Rossi, Peter, Oshodi, Taohid, Diaz, Rodney, Afifi, Rana, Dindyal, Shiva, Thapar, Ankur, Kordzadeh, Ali, Pullas, Gonzalo, Lin, Stephanie, Davies, Chris, Darvall, Katy, Kodama, Akio, Gooneratne, Thushan, Gunawansa, Nalaka, Munoz, Alberto, Jie, Ng Jun, Bradley, Nicholas, Al-Jundi, Wissam, Meyer, Felicity, Lee, Cheong, Malina, Martin, Renton, Sophie, Lui, Dennis, Batchelder, Andrew, Oszkinis, Grzegorz, Freyrie, Antonio, Giordano, Jacopo, Saratzis, Nikolaos, Tigkiropoulos, Konstantinos, Kyriakos, Stavridis, Popov, Guriy, Cheema, Muhammad Usman, Lapolla, Pierfrancesco, Ling Patricia, Yih Chun, Ennab, Raed, Ullery, Brant W., Pasenidou, Ketino, Tam, Jacky, Sidel, Gabriel, Jayaprakash, Vivek Vardhan, Bennett, Lisa, Hardy, Simon, Davies, Emma, Baker, Sara, Wijesinghe, Lasantha, Tam, Adam, McCune, Ken, Chana, Manik, Lowe, Chris, Goh, Aaron, Powezka, Katarzyna, Kyrou, Ioanna, Altaf, Nishath, Harkin, Denis, Travers, Hannah, Cragg, James, sharif, Atif, Akhtar, Tasleem, Chávez, José Antonio, Ordonez, Claudia, Mazzurco, Martin, Choke, Edward, Asghar, Imran, Summerour, Virginia, Dunlop, Paul, Morley, Rachel, Hardy, Thomas, Bevis, Paul, Cuff, Robert, Stavroulakis, Konstantinos, Beropoulis, Efthymios, Argyriou, Angeliki, Loftus, Ian, Azhar, Bilal, Sheth, Sharvil, Usai, Marco Virgilio, Choudhry, Asad, Nicole, Kira, Boyle, Emily, Joyce, Doireann, Abdelaty Hassan, Mohammed Hassan, Saltiel, Alberto, Frahm-Jensen, Gert, Antoniou, George, Elhadi, Muhammed, Kimyaghalam, Ali, Malgor, Rafael, O'Banion, Leigh Ann, Telve, Diego, Isaak, Andrej, Schmidli, Jürg, McKevitt, Kevin, Siddiqui, Tam, Asciutto, Giuseppe, Floros, Nikolaos, Papadopoulos, George, Kafetzakis, Alexandros, Koutsias, Stylianos G., Nana, Petroula, Giannoukas, Athanasios, Kakkos, Stavros, Moulakakis, Konstantinos G., Shafique, Natasha, Jawien, Arkadiusz, Popplewell, Matthew, Imray, Chris, Abayasekara, Kumar, Rowlands, Timothy, Kuhan, Ganesh, Rajagopalan, Sriram, Jaipersad, Anthony, Sadia, Uzma, Kobe, Isaac, Mittapalli, Devender, Enemosah, Ibrahim, Behrendt, Christian-Alexander, Beck, Adam, Almudhafer, Muayyad, Ancetti, Stefano, Jacobs, Donald, Jayakumar, Priya, Malekpour, Fatemeh, Shalhub, Sherene, Keldiyorov, Boboyor, Simon, Meryl, Khashram, Manar, Rich, Nicole, Shepherd, Amanda, Meecham, Lewis, Doherty, Daniel, and Benson, Ruth A.
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- 2022
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7. Latent Structure of Executive Functioning/Learning Tasks in the CogState Computerized Battery
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Nordenswan, Elisabeth, Kataja, Eeva-Leena, Deater-Deckard, Kirby, Korja, Riikka, Karrasch, Mira, Laine, Matti, Karlsson, Linnea, and Karlsson, Hasse
- Abstract
This study tested whether executive functioning (EF)/learning tasks from the CogState computerized test battery show a unitary latent structure. This information is important for the construction of composite measures on these tasks for applied research purposes. Based on earlier factor analytic research, we identified five CogState tasks that have been labeled as EF/learning tasks and examined their intercorrelations in a new sample of Finnish birth cohort mothers (N = 233). Using confirmatory factor analyses, we compared two single-factor EF/learning models. The first model included the recommended summative scores for each task. The second model exchanged summative scores for first test round results for the three tasks providing these data, as initial task performance is expected to load more heavily on EF. A single-factor solution provided a good fit for the present five EF/learning tasks. The second model, which was hypothesized to tap more onto EF, had slightly better fit indices, X[superscript 2](5) = 1.37, p = 0.93, standardized root mean square residual (SRMR) = 0.02, root mean square error of approximation (RMSEA) = 0.00, 90% CI = [0.00-0.03], comparative fit index (CFI) = 1.00, and more even factor loadings (0.30-0.56) than the first model, X[superscript 2](5) = 4.56, p = 0.47, SRMR = 0.03, RMSEA = 0.00, 90% CI = [0.00-0.09], CFI = 1.00, factor loadings (0.20-0.74), which was hypothesized to tap more onto learning. We conclude that the present CogState sum scores can be used for studying EF/learning in healthy adult samples, but call for further research to validate these sum scores against other EF tests.
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- 2020
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8. Effect of EVAR on International Ruptured AAA Mortality—Sex and Geographic Disparities
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Png, C. Y. Maximilian, primary, Pendleton, A. Alaska, additional, Altreuther, Martin, additional, Budtz-Lilly, Jacob W., additional, Gunnarsson, Kim, additional, Kan, Chung-Dann, additional, Khashram, Manar, additional, Laine, Matti T., additional, Mani, Kevin, additional, Pederson, Christian C., additional, Srivastava, Sunita D., additional, and Eagleton, Matthew J., additional
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- 2024
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9. The interplay between domain-general and domain-specific mechanisms during the time-course of verbal associative learning: An event-related potential study
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Ramos-Escobar, Neus, Laine, Matti, Sanseverino-Dillenburg, Mariana, Cucurell, David, François, Clément, and Rodriguez-Fornells, Antoni
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- 2021
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10. Strategy use and its evolvement in word list learning: a replication study
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Laine, Matti, primary, Fellman, Daniel, additional, Eräste, Tilda, additional, Ritakallio, Liisa, additional, and Salmi, Juha, additional
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- 2024
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11. A Latent Factor Analysis of Working Memory Measures Using Large-Scale Data
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Waris, Otto, Soveri, Anna, Ahti, Miikka, Hoffing, Russell C, Ventus, Daniel, Jaeggi, Susanne M, Seitz, Aaron R, and Laine, Matti
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Biological Psychology ,Psychology ,Applied and Developmental Psychology ,Mental Health ,Clinical Research ,Neurosciences ,working memory ,latent variable ,confirmatory factor analysis ,exploratory factor analysis ,simple span ,complex span ,running memory task ,n-back ,Cognitive Sciences ,Biomedical and clinical sciences - Abstract
Working memory (WM) is a key cognitive system that is strongly related to other cognitive domains and relevant for everyday life. However, the structure of WM is yet to be determined. A number of WM models have been put forth especially by factor analytical studies. In broad terms, these models vary by their emphasis on WM contents (e.g., visuospatial, verbal) vs. WM processes (e.g., maintenance, updating) as critical, dissociable elements. Here we conducted confirmatory and exploratory factor analyses on a broad set of WM tasks, half of them numerical-verbal and half of them visuospatial, representing four commonly used task paradigms: simple span, complex span, running memory, and n-back. The tasks were selected to allow the detection of both content-based (visuospatial, numerical-verbal) and process-based (maintenance, updating) divisions. The data were collected online which allowed the recruitment of a large and demographically diverse sample of adults (n = 711). Both factor analytical methods pointed to a clear division according to task content for all paradigms except n-back, while there was no indication for a process-based division. Besides the content-based division, confirmatory factor analyses supported a model that also included a general WM factor. The n-back tasks had the highest loadings on the general factor, suggesting that this factor reflected high-level cognitive resources such as executive functioning and fluid intelligence that are engaged with all WM tasks, and possibly even more so with the n-back. Together with earlier findings that indicate high variability of process-based WM divisions, we conclude that the most robust division of WM is along its contents (visuospatial vs. numerical-verbal), rather than along its hypothetical subprocesses.
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- 2017
12. Spontaneous strategy use during a working memory updating task
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Waris, Otto, Jylkkä, Jussi, Fellman, Daniel, and Laine, Matti
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- 2021
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13. Breaking down the cocktail party: Attentional modulation of cerebral audiovisual speech processing
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Wikman, Patrik, Sahari, Elisa, Salmela, Viljami, Leminen, Alina, Leminen, Miika, Laine, Matti, and Alho, Kimmo
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- 2021
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14. Effect of EVAR on International Ruptured AAA Mortality-Sex and Geographic Disparities
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Png, C. Y. Maximilian, Pendleton, A. Alaska, Altreuther, Martin, Budtz-Lilly, Jacob W., Gunnarsson, Kim, Kan, Chung-Dann, Khashram, Manar, Laine, Matti T., Mani, Kevin, Pederson, Christian C., Srivastava, Sunita D., Eagleton, Matthew J., Png, C. Y. Maximilian, Pendleton, A. Alaska, Altreuther, Martin, Budtz-Lilly, Jacob W., Gunnarsson, Kim, Kan, Chung-Dann, Khashram, Manar, Laine, Matti T., Mani, Kevin, Pederson, Christian C., Srivastava, Sunita D., and Eagleton, Matthew J.
- Abstract
Background: We sought to investigate the differential impact of EVAR (endovascular aneurysm repair) vis-á-vis OSR (open surgical repair) on ruptured AAA (abdominal aortic aneurysm) mortality by sex and geographically. Methods: We performed a retrospective study of administrative data on EVAR from state statistical agencies, vascular registries, and academic publications, as well as ruptured AAA mortality rates from the World Health Organization for 14 14 states across Australasia, East Asia, Europe, and North America. Results: Between 2011-2016, the proportion of treatment of ruptured AAAs by EVAR increased from 26.1 to 43.8 percent among females, and from 25.7 to 41.2 percent among males, and age-adjusted ruptured AAA mortality rates fell from 12.62 to 9.50 per million among females, and from 34.14 to 26.54 per million among males. The association of EVAR with reduced mortality was more than three times larger (2.2 vis-á-vis 0.6 percent of prevalence per 10 percentage point increase in EVAR) among females than males. The association of EVAR with reduced mortality was substantially larger (1.7 vis-á-vis 1.1 percent of prevalence per 10 percentage point increase in EVAR) among East Asian states than European+ states. Conclusions: The increasing adoption of EVAR coincided with a decrease in ruptured AAA mortality. The relationship between EVAR and mortality was more pronounced among females than males, and in East Asian than European+ states. Sex and ethnic heterogeneity should be further investigated.
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- 2024
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15. ADHD desynchronizes brain activity during watching a distracted multi-talker conversation
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Salmi, Juha, Metwaly, Mostafa, Tohka, Jussi, Alho, Kimmo, Leppämäki, Sami, Tani, Pekka, Koski, Anniina, Vanderwal, Tamara, and Laine, Matti
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- 2020
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16. Attention to audiovisual speech shapes neural processing through feedback-feedforward loops between different nodes of the speech network.
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Wikman, Patrik, Salmela, Viljami, Sjöblom, Eetu, Leminen, Miika, Laine, Matti, and Alho, Kimmo
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SPEECH ,FUNCTIONAL magnetic resonance imaging ,EXECUTIVE function ,AUDITORY cortex ,SELECTIVITY (Psychology) ,SPEECH perception - Abstract
Selective attention-related top-down modulation plays a significant role in separating relevant speech from irrelevant background speech when vocal attributes separating concurrent speakers are small and continuously evolving. Electrophysiological studies have shown that such top-down modulation enhances neural tracking of attended speech. Yet, the specific cortical regions involved remain unclear due to the limited spatial resolution of most electrophysiological techniques. To overcome such limitations, we collected both electroencephalography (EEG) (high temporal resolution) and functional magnetic resonance imaging (fMRI) (high spatial resolution), while human participants selectively attended to speakers in audiovisual scenes containing overlapping cocktail party speech. To utilise the advantages of the respective techniques, we analysed neural tracking of speech using the EEG data and performed representational dissimilarity-based EEG-fMRI fusion. We observed that attention enhanced neural tracking and modulated EEG correlates throughout the latencies studied. Further, attention-related enhancement of neural tracking fluctuated in predictable temporal profiles. We discuss how such temporal dynamics could arise from a combination of interactions between attention and prediction as well as plastic properties of the auditory cortex. EEG-fMRI fusion revealed attention-related iterative feedforward-feedback loops between hierarchically organised nodes of the ventral auditory object related processing stream. Our findings support models where attention facilitates dynamic neural changes in the auditory cortex, ultimately aiding discrimination of relevant sounds from irrelevant ones while conserving neural resources. Selective attention enables separation of overlapping speech in noisy environments. This study shows that attention triggers bidirectional informational flow from sensory regions to regions associated with semantic, syntactic and executive functions during active processing of cocktail-party speech. [ABSTRACT FROM AUTHOR]
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- 2024
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17. The Effect of a Suspended Radiation Protection System on Occupational Radiation Doses During Infrarenal EVAR Procedures: A Randomised Controlled Study
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Serna Santos, Juan, primary, Kaasalainen, Touko, additional, Laukontaus, Sani, additional, Björkman, Patrick, additional, Heinola, Ivika, additional, Laine, Matti, additional, Vikatmaa, Pirkka, additional, Pekkarinen, Antti, additional, Venermo, Maarit, additional, and Aho, Pekka, additional
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- 2023
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18. Assessment of goal-directed behavior and prospective memory in adult ADHD with an online 3D videogame simulating everyday tasks
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Jylkkä, Jussi, primary, Ritakallio, Liisa, additional, Merzon, Liya, additional, Kangas, Suvi, additional, Kliegel, Matthias, additional, Zuber, Sascha, additional, Hering, Alexandra, additional, Laine, Matti, additional, and Salmi, Juha, additional
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- 2023
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19. Assessing goal-directed behavior in virtual reality with the neuropsychological task EPELI: children prefer head-mounted display but flat screen provides a viable performance measure for remote testing
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Seesjärvi, Erik, primary, Laine, Matti, additional, Kasteenpohja, Kaisla, additional, and Salmi, Juha, additional
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- 2023
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20. Assessment of goal-directed behavior with the 3D videogame EPELI: Psychometric features in a web-based adult sample
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Jylkkä, Jussi, primary, Ritakallio, Liisa, additional, Merzon, Liya, additional, Kangas, Suvi, additional, Kliegel, Matthias, additional, Zuber, Sascha, additional, Hering, Alexandra, additional, Salmi, Juha, additional, and Laine, Matti, additional
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- 2023
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21. Spontaneous memory strategies in a videogame simulating everyday memory tasks
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Laine, Matti, Jylkka, Jussi, Ritakallio, Liisa, Eraste, Tilda, Kangas, Suvi, Hering, Alexandra, Zuber, Sascha, Kliegel, Matthias, Fellman, Daniel, Salmi, Juha, Laine, Matti, Jylkka, Jussi, Ritakallio, Liisa, Eraste, Tilda, Kangas, Suvi, Hering, Alexandra, Zuber, Sascha, Kliegel, Matthias, Fellman, Daniel, and Salmi, Juha
- Abstract
People can use different internal strategies to manage their daily tasks, but systematic research on these strategies and their significance for actual performance is still quite sparse. Here we examined self-reported internal strategy use with a 10-block version of the videogame EPELI (Executive Performance in Everyday LIving) in a group of 202 neurotypical adults of 18-50 years of age. In the game, participants perform lists of everyday tasks from memory while navigating in a virtual apartment. Open-ended strategy reports were collected after each EPELI task block, and for comparison also after an EPELI Instruction Recall task and a Word List Learning task assessing episodic memory. On average, 45% of the participants reported using some strategy in EPELI, the most common types being grouping (e.g., performing the tasks room by room), utilising a familiar action schema, and condensing information (e.g., memorising only keywords). Our pre-registered hypothesis on the beneficial effect of self-initiated strategy use gained support, as strategy users showed better performance on EPELI as compared with no strategy users. One of the strategies, grouping, was identified as a clearly effective strategy type. Block-by-block transitions suggested gradual stabilisation of strategy use over the 10 EPELI blocks. The proneness to use strategies showed a weak but reliable association between EPELI and Word List Learning. Overall, the present results highlight the importance of internal strategy use for understanding individual differences in memory performance, as well as the potential benefit for internal strategy employment when faced with everyday memory tasks.
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- 2023
22. EPELI: A novel virtual reality task for the assessment of goal-directed behavior in real-life contexts
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Seesjärvi, Erik, Puhakka, Jasmin, Aronen, Eeva T., Hering, Alexandra, Zuber, Sascha, Merzon, Liya, Kliegel, Matthias, Laine, Matti, Salmi, Juha, Seesjärvi, Erik, Puhakka, Jasmin, Aronen, Eeva T., Hering, Alexandra, Zuber, Sascha, Merzon, Liya, Kliegel, Matthias, Laine, Matti, and Salmi, Juha
- Abstract
A recently developed virtual reality task, EPELI (Executive Performance in Everyday LIving), quantifies goal-directed behavior in naturalistic conditions. Participants navigate a virtual apartment, performing household chores given by a virtual character. EPELI aims to tap attention, executive function, and prospective memory. To ensure its applicability to further research and clinical work and to study its relationship to relevant background factors, we examined several key properties of EPELI in 77 typically developing 9–13-year-old children. These included EPELI’s internal consistency, age and gender differences, sensitivity to gaming experience, head-mounted display (HMD) type, and verbal recall ability, as well as its relationships with parent-rated everyday executive problems. Of the eight EPELI measures, the following six showed acceptable internal consistency: task and navigation efficacy, number of correctly performed tasks and overall actions, time monitoring, and controller movement. Some measures were associated with age, gender, or verbal encoding ability. Moreover, EPELI performance was associated with parent-rated everyday executive problems. There were no significant associations of gaming background, task familiarity, or HMD type with the EPELI measures. These results attest to the reliability and ecological validity of this new virtual reality tool for the assessment of attention, executive functions, and prospective memory in children.
- Published
- 2023
23. Abnormal wiring of the structural connectome in adults with ADHD
- Author
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Tolonen, Tuija, primary, Roine, Timo, additional, Alho, Kimmo, additional, Leppämäki, Sami, additional, Tani, Pekka, additional, Koski, Anniina, additional, Laine, Matti, additional, and Salmi, Juha, additional
- Published
- 2023
- Full Text
- View/download PDF
24. Routine Inferior Mesenteric Artery Embolisation is Unnecessary Before Endovascular Aneurysm Repair
- Author
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Väärämäki, Suvi, primary, Viitala, Herman, additional, Laukontaus, Sani, additional, Uurto, Ilkka, additional, Björkman, Patrick, additional, Tulamo, Riikka, additional, Aho, Pekka, additional, Laine, Matti, additional, Suominen, Velipekka, additional, and Venermo, Maarit, additional
- Published
- 2022
- Full Text
- View/download PDF
25. The Pursuit of Effective Working Memory Training : a Pre-registered Randomised Controlled Trial with a Novel Varied Training Protocol
- Author
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Ritakallio, Liisa, Fellman, Daniel, Jylkkä, Jussi, Waris, Otto, Lönnroth, Nelly, Nervander, Reidar, Salmi, Juha, Laine, Matti, Ritakallio, Liisa, Fellman, Daniel, Jylkkä, Jussi, Waris, Otto, Lönnroth, Nelly, Nervander, Reidar, Salmi, Juha, and Laine, Matti
- Abstract
Working memory (WM) training, typically entailing repetitive practice with one or two tasks, has mostly yielded only limited task-specific transfer effects. We developed and tested a new WM training approach where the task paradigm, stimulus type, and predictability of the stimulus sequence were constantly altered during the 4-week training period. We expected that this varied training protocol would generate more extensive transfer by facilitating the use of more general strategies that could be applied to a range of WM tasks. Pre-post transfer effects following varied training (VT group, n = 60) were compared against traditional training (TT group, training a single adaptive WM task, n = 63), and active controls (AC, n = 65). As expected, TT evidenced strong task-specific near transfer as compared to AC. In turn, VT exhibited task-specific near transfer only on one of the measures, and only as compared to the TT group. Critically, no evidence for task-general near transfer or far transfer effects was observed. In sum, the present form of VT failed to demonstrate broader transfer. Nevertheless, as VT has met with success in other cognitive domains, future studies should probe if and how it would be possible to design WM training protocols that promote structural learning where common features of specific tasks would be identified and utilised when selecting strategies for novel memory tasks.
- Published
- 2022
- Full Text
- View/download PDF
26. Quantifying ADHD symptoms in open-ended everyday life contexts with a new virtual reality task
- Author
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Seesjärvi, Erik, Puhakka, Jasmin, Aronen, Eeva T., Lipsanen, Jari, Mannerkoski, Minna, Hering, Alexandra, Zuber, Sascha, Kliegel, Matthias, Laine, Matti, Salmi, Juha, Seesjärvi, Erik, Puhakka, Jasmin, Aronen, Eeva T., Lipsanen, Jari, Mannerkoski, Minna, Hering, Alexandra, Zuber, Sascha, Kliegel, Matthias, Laine, Matti, and Salmi, Juha
- Abstract
Objective: To quantify goal-directed behavior and ADHD symptoms in naturalistic conditions, we developed a virtual reality task, EPELI (Executive Performance in Everyday LIving), and tested its predictive, discriminant and concurrent validity. Method: We collected EPELI data, conventional neuropsychological task data, and parent-ratings of executive problems and symptoms in 38 ADHD children and 38 typically developing controls. Results:EPELI showed predictive validity as the ADHD group exhibited higher percentage of irrelevant actions reflecting lower attentional-executive efficacy and more controller movements and total game actions, both indicative of hyperactivity-impulsivity. Further, the five combined EPELI measures showed excellent discriminant validity (area under curve 88 %), while the correlations of the EPELI efficacy measure with parent-rated executive problems (r =.57) and ADHD symptoms (r =.55) pointed to its concurrent validity. Conclusion: We provide a proof-of-concept validation for a new virtual reality tool for ecologically valid assessment of ADHD symptoms.
- Published
- 2022
27. A Population-Based Study of Abdominal Aortic Aneurysm Treatment in Finland 2000 to 2014
- Author
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Laine, Matti T., Laukontaus, Sani J., Sund, Reijo, Aho, Pekka S., Kantonen, Ilkka, Albäck, Anders, and Venermo, Maarit
- Published
- 2017
- Full Text
- View/download PDF
28. Few internal iliac artery aneurysms rupture under 4 cm
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Laine, Matti T., Björck, Martin, Beiles, Barry C., Szeberin, Zoltán, Thomson, Ian, Altreuther, Martin, Debus, Sebastian E., Mani, Kevin, Menyhei, Gábor, and Venermo, Maarit
- Published
- 2017
- Full Text
- View/download PDF
29. Routine Inferior Mesenteric Artery Embolisation is Unnecessary Before Endovascular Aneurysm Repair.
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Väärämäki, Suvi, Viitala, Herman, Laukontaus, Sani, Uurto, Ilkka, Björkman, Patrick, Tulamo, Riikka, Aho, Pekka, Laine, Matti, Suominen, Velipekka, and Venermo, Maarit
- Abstract
A type II endoleak is the most common complication during surveillance after endovascular aneurysm repair (EVAR), and a patent inferior mesenteric artery (IMA) is a known risk factor for an endoleak. The effect of routine IMA embolisation prior to EVAR on overall outcome is unknown. The aim of the study was to compare two strategies: routine attempted IMA embolisation prior to EVAR (strategy in centre A) and leaving the IMA untouched (strategy in centre B). Patients were treated with EVAR in two centres during the period 2005 – 2015, and the data were reviewed retrospectively. The primary endpoints were re-intervention rate due to type II endoleaks and the late IMA embolisation rate. Secondary endpoints included EVAR related re-intervention, sac enlargement, aneurysm rupture, and open conversion rates. Strategy A was used to treat 395 patients. The IMA was patent in 268 (67.8%) patients, and embolisation was performed in 164 (41.5%). The corresponding figures for strategy B were 337 patients with 279 (82.8%) patent IMAs, two (0.6%) of which were embolised. The mean duration of follow up was 70 months for strategy A and 68.2 months for strategy B. The re-intervention rates due to a type II endoleak were 12.9% and 10.4%, respectively (p =.29), with no significant difference in the rate of re-interventions to occlude a patent IMA (2.0% and 4.7%, respectively; p =.039). The EVAR related re-intervention rate was similar, regardless of strategy (24.1% and 24.6%, respectively; p =.93). Significant sac enlargement was seen in 20.3% of cases treated with strategy A and in 19.6% treated with strategy B (p =.82). The rupture and conversion rates were 2.5% and 2.1% (p =.69) and 1.0% and 1.5% (p =.40), respectively. The strategy of routinely embolising the IMA does not seem to yield any significant clinical benefit and should therefore be abandoned. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
30. Effects of Working-Memory Training on Striatal Dopamine Release
- Author
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Bäckman, Lars, Nyberg, Lars, Soveri, Anna, Johansson, Jarkko, Andersson, Micael, Dahlin, Erika, Neely, Anna S., Virta, Jere, Laine, Matti, and Rinne, Juha O.
- Published
- 2011
- Full Text
- View/download PDF
31. The Pursuit of Effective Working Memory Training
- Author
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Ritakallio, Liisa, Fellman, Daniel, Jylkka, Jussi, Waris, Otto, Lonnroth, Nelly, Nervander, Reidar, Salmi, Juha, Laine, Matti, Aalto University, Department of Neuroscience and Biomedical Engineering, and Aalto-yliopisto
- Subjects
Cognitive training ,AGE-DIFFERENCES ,Working memory ,TASK ,SHORT-TERM ,FAR-TRANSFER ,STRATEGY USE ,SPAN ,Memory training ,Structural learning ,Varied training ,Skill acquisition - Abstract
Working memory (WM) training, typically entailing repetitive practice with one or two tasks, has mostly yielded only limited task-specific transfer effects. We developed and tested a new WM training approach where the task paradigm, stimulus type, and predictability of the stimulus sequence were constantly altered during the 4-week training period. We expected that this varied training protocol would generate more extensive transfer by facilitating the use of more general strategies that could be applied to a range of WM tasks. Pre-post transfer effects following varied training (VT group, n = 60) were compared against traditional training (TT group, training a single adaptive WM task, n = 63), and active controls (AC, n = 65). As expected, TT evidenced strong task-specific near transfer as compared to AC. In turn, VT exhibited task-specific near transfer only on one of the measures, and only as compared to the TT group. Critically, no evidence for task-general near transfer or far transfer effects was observed. In sum, the present form of VT failed to demonstrate broader transfer. Nevertheless, as VT has met with success in other cognitive domains, future studies should probe if and how it would be possible to design WM training protocols that promote structural learning where common features of specific tasks would be identified and utilised when selecting strategies for novel memory tasks.
- Published
- 2021
32. Paradoxical Vocabulary Learning in the Face of Extensive Left Temporal Lobe Damage and Chronic Aphasia
- Author
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Tuomiranta, Leena, Rautakoski, Pirkko, Martin, Nadine, and Laine, Matti
- Published
- 2011
- Full Text
- View/download PDF
33. Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study
- Author
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Benson, Ruth A., primary, Ruffino, Maria Antonella, additional, Chan, Sharon, additional, Coughlin, Patrick, additional, Awopetu, Ayoola, additional, Stather, Philip, additional, Lane, Tristan, additional, Theodosiou, Dimitrios, additional, Ahmed, Mohamed Abozeid, additional, Vasudevan, Thodur, additional, Ibrahim, Mohammed, additional, Al Maadany, Faraj, additional, Eljareh, Mohamed, additional, Alkhafeefi, Fatimah Saad, additional, Coscas, Raphael, additional, Ünal, Ertekin Utku, additional, Pulli, Raffaele, additional, Zacà, Sergio, additional, Angiletta, Domenico, additional, Kotsis, Thomas, additional, Moawad, Magdy, additional, Tozzi, Matteo, additional, Patelis, Nikolaos, additional, Lazaris, Andreas M., additional, Chuen, Jason, additional, Croo, Alexander, additional, Tsolaki, Elpiniki, additional, Zenunaj, Gladiol, additional, Kamal, Dhafer, additional, Tolba, Mahmoud MH., additional, Maresch, Martin, additional, Khetarpaul, Vipul, additional, Mills, Joseph, additional, Gangwani, Gaurav, additional, Elahwal, Mohamed, additional, Khalil, Rana, additional, Azab, Mohammed A., additional, Mahomed, Anver, additional, Whiston, Richard, additional, Contractor, Ummul, additional, Esposito, Davide, additional, Pratesi, Carlo, additional, Giacomelli, Elena, additional, Troncoso, Martín Veras, additional, Elkouri, Stephane, additional, Johansson, Flavia Gentile, additional, Dodos, Ilias, additional, Benezit, Marie, additional, Vidoedo, José, additional, Rocha-Neves, João, additional, Pereira-Neves, António Henrique, additional, Dias-Neto, Marina Felicidade, additional, Campos Jácome, Ana Filipa, additional, Loureiro, Luis, additional, Silva, Ivone, additional, Garza-Herrera, Rodrigo, additional, Canata, Victor, additional, Bezard, Charlotte, additional, Bowser, Kathryn, additional, Tobar, Jorge Felipe, additional, Vera, Carlos Gomez, additional, Parra, Carolina Salinas, additional, Lopez, Eugenia, additional, Serra, Yvis Gadelha, additional, Varela, Juan, additional, Rubio, Vanessa, additional, Victoria, Gerardo, additional, Johnson, Adam, additional, O’Banion, Leigh Ann, additional, Makar, Ragai, additional, Tantawy, Tamer Ghatwary, additional, Storck, Martin, additional, Jongkind, Vincent, additional, falah, Orwa, additional, McBride, Olivia, additional, Isik, Arda, additional, Papaioannou, Athanasios, additional, Ocke Reis, Paulo Eduardo, additional, Bracale, Umberto Marcello, additional, Atkins, Ellie, additional, Tinelli, Giovanni, additional, Scott, Emma, additional, Wales, Lucy, additional, Sivaharan, Ashwin, additional, Priona, Georgia, additional, Nesbitt, Craig, additional, Grainger, Tabitha, additional, Shelmerdine, Lauren, additional, Chong, Patrick, additional, Bajwa, Adnan, additional, Arwynck, Luke, additional, Hadjievangelou, Nancy, additional, Elbasty, Ahmed, additional, Rubio, Oscar, additional, Ricardo, Michael, additional, Ulloa, Jorge H., additional, Tarazona, Marcos, additional, Pabon, Manuel, additional, Pitoulias, Georgios, additional, Corless, Kevin, additional, Ioannidis, Orestis, additional, Friedrich, Oliver, additional, Van Herzeele, Isabelle, additional, Vijaynagar, Badri, additional, Cohnert, Tina, additional, Bell, Rachel, additional, Moore, Hayley, additional, Saha, Prakash, additional, Gifford, Edward, additional, Laine, Matti, additional, Barkat, Adel, additional, Karkos, Christos, additional, Binti Safri, Lenny Suryani, additional, Buitron, Gabriel, additional, Del Castillo, Javier, additional, Carrera, Paul, additional, Salinas, Nilson, additional, Biagioni, Rodrigo Bruno, additional, Benites, Sergio, additional, Mafla, César Andrés, additional, Pian, Putera Mas, additional, Albino, Pereira, additional, Serrano, Ernesto, additional, Marin, Andres, additional, González, Marco, additional, Foreroga, Marsha, additional, Russo, Alejandro, additional, Reyes, Andrés, additional, Guglielmone, Daniel, additional, Grillo, Lorena, additional, Flumignan, Ronald, additional, Palones, Francisco Gomez, additional, Silveira, Pierre Galvagni, additional, Ramely, Rosnelifaizur Bin, additional, Edeiken, Sara, additional, Chetter, Ian, additional, Green, Lucy, additional, Sudarsanam, Abhilash, additional, Lyons, Oliver, additional, Lemmon, Gary, additional, Neville, Richard, additional, Castelli, Mariano, additional, Hinojosa, Carlos A., additional, Carvajal, Rubén Rodríguez, additional, Rivera, Aksim, additional, Wong, Peng, additional, Drudi, Laura, additional, Perkins, Jeremy, additional, Sieunarine, Kishore, additional, Attia, Doaa, additional, Atef, Mahmoud, additional, Eftychios, Lostoridis, additional, Weaver, Fred, additional, Ren, Leong Chuo, additional, Alomari, Mohannad, additional, Jamjoom, Reda, additional, Aljarrah, Qusai, additional, Abbas, Ayman, additional, Alomran, Faris, additional, Kumar, Ambrish, additional, Altoijri, Abdulmajeed, additional, ElSanhoury, Kareem T., additional, Alhumaid, Ahmed, additional, Fekry, Tamer, additional, Sekhar, Raghuram, additional, Theodoridis, Panagiotis, additional, Panagiotis, Theodoridis, additional, Roditis, Konstantinos, additional, Tsiantoula, Paraskevi, additional, Antoniou, Afroditi, additional, Soler, Raphael, additional, Hasemaki, Natasha, additional, Baili, Efstratia, additional, Mpaili, Eustratia, additional, Huasen, Bella, additional, Wallace, Tom, additional, Duncan, Andrew, additional, Metcalfe, Matthew, additional, Mannoia, Kristyn, additional, Bechara, Carlos F., additional, Tsilimparis, Nikolaos, additional, Aranson, Nathan, additional, Riding, David, additional, Palena, Mariano, additional, McDonnell, Ciarán, additional, Mouawad, Nicolas J., additional, Banegas, Shonda, additional, Rossi, Peter, additional, Oshodi, Taohid, additional, Diaz, Rodney, additional, Afifi, Rana, additional, Dindyal, Shiva, additional, Thapar, Ankur, additional, Kordzadeh, Ali, additional, Pullas, Gonzalo, additional, Lin, Stephanie, additional, Davies, Chris, additional, Darvall, Katy, additional, Kodama, Akio, additional, Gooneratne, Thushan, additional, Gunawansa, Nalaka, additional, Munoz, Alberto, additional, Jie, Ng Jun, additional, Bradley, Nicholas, additional, Al-Jundi, Wissam, additional, Meyer, Felicity, additional, Lee, Cheong, additional, Malina, Martin, additional, Renton, Sophie, additional, Lui, Dennis, additional, Batchelder, Andrew, additional, Oszkinis, Grzegorz, additional, Freyrie, Antonio, additional, Giordano, Jacopo, additional, Saratzis, Nikolaos, additional, Tigkiropoulos, Konstantinos, additional, Kyriakos, Stavridis, additional, Popov, Guriy, additional, Cheema, Muhammad Usman, additional, Lapolla, Pierfrancesco, additional, Ling Patricia, Yih Chun, additional, Ennab, Raed, additional, Ullery, Brant W., additional, Pasenidou, Ketino, additional, Tam, Jacky, additional, Sidel, Gabriel, additional, Jayaprakash, Vivek Vardhan, additional, Bennett, Lisa, additional, Hardy, Simon, additional, Davies, Emma, additional, Baker, Sara, additional, Wijesinghe, Lasantha, additional, Tam, Adam, additional, McCune, Ken, additional, Chana, Manik, additional, Lowe, Chris, additional, Goh, Aaron, additional, Powezka, Katarzyna, additional, Kyrou, Ioanna, additional, Altaf, Nishath, additional, Harkin, Denis, additional, Travers, Hannah, additional, Cragg, James, additional, sharif, Atif, additional, Akhtar, Tasleem, additional, Chávez, José Antonio, additional, Ordonez, Claudia, additional, Mazzurco, Martin, additional, Choke, Edward, additional, Asghar, Imran, additional, Summerour, Virginia, additional, Dunlop, Paul, additional, Morley, Rachel, additional, Hardy, Thomas, additional, Bevis, Paul, additional, Cuff, Robert, additional, Stavroulakis, Konstantinos, additional, Beropoulis, Efthymios, additional, Argyriou, Angeliki, additional, Loftus, Ian, additional, Azhar, Bilal, additional, Sheth, Sharvil, additional, Usai, Marco Virgilio, additional, Choudhry, Asad, additional, Nicole, Kira, additional, Boyle, Emily, additional, Joyce, Doireann, additional, Abdelaty Hassan, Mohammed Hassan, additional, Saltiel, Alberto, additional, Frahm-Jensen, Gert, additional, Antoniou, George, additional, Elhadi, Muhammed, additional, Kimyaghalam, Ali, additional, Malgor, Rafael, additional, O'Banion, Leigh Ann, additional, Telve, Diego, additional, Isaak, Andrej, additional, Schmidli, Jürg, additional, McKevitt, Kevin, additional, Siddiqui, Tam, additional, Asciutto, Giuseppe, additional, Floros, Nikolaos, additional, Papadopoulos, George, additional, Kafetzakis, Alexandros, additional, Koutsias, Stylianos G., additional, Nana, Petroula, additional, Giannoukas, Athanasios, additional, Kakkos, Stavros, additional, Moulakakis, Konstantinos G., additional, Shafique, Natasha, additional, Jawien, Arkadiusz, additional, Popplewell, Matthew, additional, Imray, Chris, additional, Abayasekara, Kumar, additional, Rowlands, Timothy, additional, Kuhan, Ganesh, additional, Rajagopalan, Sriram, additional, Jaipersad, Anthony, additional, Sadia, Uzma, additional, Kobe, Isaac, additional, Mittapalli, Devender, additional, Enemosah, Ibrahim, additional, Behrendt, Christian-Alexander, additional, Beck, Adam, additional, Almudhafer, Muayyad, additional, Ancetti, Stefano, additional, Jacobs, Donald, additional, Jayakumar, Priya, additional, Malekpour, Fatemeh, additional, Shalhub, Sherene, additional, Keldiyorov, Boboyor, additional, Simon, Meryl, additional, Khashram, Manar, additional, Rich, Nicole, additional, Shepherd, Amanda, additional, Meecham, Lewis, additional, and Doherty, Daniel, additional
- Published
- 2022
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- View/download PDF
34. Maternal Psychological Distress and Executive Functions Are Associated During Early Parenthood – A FinnBrain Birth Cohort Study
- Author
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Nordenswan, Elisabeth, primary, Deater-Deckard, Kirby, additional, Kataja, Eeva-Leena, additional, Karrasch, Mira, additional, Pelto, Juho, additional, Laine, Matti, additional, Karlsson, Hasse, additional, Karlsson, Linnea, additional, and Korja, Riikka, additional
- Published
- 2021
- Full Text
- View/download PDF
35. Maternal Executive Functioning, Emotional Availability and Psychological Distress During Toddlerhood: A FinnBrain Birth Cohort Study
- Author
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Nordenswan, Elisabeth, primary, Deater-Deckard, Kirby, additional, Karrasch, Mira, additional, Laine, Matti, additional, Kataja, Eeva-Leena, additional, Holmberg, Eeva, additional, Eskola, Eeva, additional, Hakanen, Hetti, additional, Karlsson, Hasse, additional, Karlsson, Linnea, additional, and Korja, Riikka, additional
- Published
- 2021
- Full Text
- View/download PDF
36. Long-Term Test–Retest Reliability of Striatal and Extrastriatal Dopamine D2/3 Receptor Binding: Study with [11C]Raclopride and High-Resolution PET
- Author
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Alakurtti, Kati, Johansson, Jarkko J, Joutsa, Juho, Laine, Matti, Bäckman, Lars, Nyberg, Lars, and Rinne, Juha O
- Published
- 2015
- Full Text
- View/download PDF
37. Breaking down the cocktail party
- Author
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Wikman, Patrik, Sahari, Elisa, Salmela, Viljami, Leminen, Alina, Leminen, Miika, Laine, Matti, Alho, Kimmo, University of Helsinki, Åbo Akademi University, Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, and Aalto University
- Subjects
Audiovisual speech ,Multivariate pattern analysis (MVPA) ,fMRI ,otorhinolaryngologic diseases ,Selective attention ,Cocktail party ,Semantics - Abstract
Recent studies utilizing electrophysiological speech envelope reconstruction have sparked renewed interest in the cocktail party effect by showing that auditory neurons entrain to selectively attended speech. Yet, the neural networks of attention to speech in naturalistic audiovisual settings with multiple sound sources remain poorly understood. We collected functional brain imaging data while participants viewed audiovisual video clips of lifelike dialogues with concurrent distracting speech in the background. Dialogues were presented in a full-factorial design, comprising task (listen to the dialogues vs. ignore them), audiovisual quality and semantic predictability. We used univariate analyses in combination with multivariate pattern analysis (MVPA) to study modulations of brain activity related to attentive processing of audiovisual speech. We found attentive speech processing to cause distinct spatiotemporal modulation profiles in distributed cortical areas including sensory and frontal-control networks.Semantic coherence modulated attention-related activation patterns in the earliest stages of auditory cortical processing, suggesting that the auditory cortex is involved in high-level speech processing. Our results corroborate views that emphasize the dynamic nature of attention, with task-specificity and context as cornerstones of the underlying neuro-cognitive mechanisms.
- Published
- 2021
38. Stimulus novelty, task demands, and strategy use in episodic memory
- Author
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Waris, Otto, Fellman, Daniel, Jylkkä, Jussi, Laine, Matti, Waris, Otto, Fellman, Daniel, Jylkkä, Jussi, and Laine, Matti
- Abstract
Cognitive task performance is a dynamic process that evolves over time, starting from the first encounters with a task. An important aspect of these task dynamics is the employment of strategies to support successful performance and task acquisition. Focusing on episodic memory performance, we: (1) tested two hypotheses on the effects of novelty and task difficulty on strategy use, (2) replicated our previous results regarding strategy use in a novel memory task, and (3) evaluated whether repeated open-ended strategy queries affect task performance and/or strategy use. The present pre-registered online study comprised 161 adult participants who were recruited through the Prolific crowdsourcing platform. We employed two separate 5-block list learning tasks, one with 10 pseudowords and the other with 18 common nouns, and collected recall performance and strategy reports for each block. Using Bayesian linear mixed effects models, the present findings (1) provide some support for the hypothesis that task-initial strategy development is not triggered only by task novelty, but can appear also in a familiar, moderately demanding task; (2) replicate earlier findings from an adaptive working memory task indicating strategy use from the beginning of a task, associations between strategy use and objective task performance, and only modest agreement between open-ended versus list-based strategy reports; and (3) indicate that repeated open-ended strategy reports do not affect objective recall. We conclude that strategy use is an important aspect of memory performance right from the start of a task, and it undergoes development at the initial stages depending on task characteristics. In a larger perspective, the present results concur with the views of skill learning and adaptivity in cognitive task performance.
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- 2021
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- View/download PDF
39. Music and speech listening enhance the recovery of early sensory processing after stroke
- Author
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Sarkamo, Teppo, Pihko, Elina, Laitinen, Sari, Forsblom, Anita, Soinila, Seppo, Mikkonen, Mikko, Autti, Taina, Silvennoinen, Heli M., Erkkila, Jaakko, Laine, Matti, Peretz, Isabelle, Hietanen, Marja, and Tervaniemi, Mari
- Subjects
Stroke (Disease) -- Care and treatment ,Stroke (Disease) -- Research ,Listening -- Physiological aspects ,Listening -- Research ,Music -- Research ,Sensory memory -- Research ,Health ,Psychology and mental health - Published
- 2010
40. Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury
- Author
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Martínez-Molina, Noelia, primary, Siponkoski, Sini-Tuuli, additional, Kuusela, Linda, additional, Laitinen, Sari, additional, Holma, Milla, additional, Ahlfors, Mirja, additional, Jordan-Kilkki, Päivi, additional, Ala-Kauhaluoma, Katja, additional, Melkas, Susanna, additional, Pekkola, Johanna, additional, Rodríguez-Fornells, Antoni, additional, Laine, Matti, additional, Ylinen, Aarne, additional, Rantanen, Pekka, additional, Koskinen, Sanna, additional, Cowley, Benjamin Ultan, additional, and Särkämö, Teppo, additional
- Published
- 2021
- Full Text
- View/download PDF
41. Disentangling the Role of Working Memory in Parkinson’s Disease
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Salmi, Juha, Ritakallio, Liisa, Fellman, Daniel, Ellfolk, Ulla, Rinne, Juha O., Laine, Matti, Department of Neuroscience and Biomedical Engineering, Åbo Akademi University, Turku University Hospital, Aalto-yliopisto, and Aalto University
- Subjects
depression ,Parkinson’s disease ,affective symptoms ,working memory ,Neuroscience ,Original Research ,cognitive impairment - Abstract
Working memory (WM) represents a core cognitive function with a major striatal contribution, and thus WM deficits, commonly observed in Parkinson’s disease (PD), could also relate to many other problems in PD patients. Our online study aimed to determine the subdomains of WM that are particularly affected in PD and to clarify the links between WM and everyday cognitive deficits, other executive functions, psychiatric and PD symptoms, as well as early cognitive impairment. Fifty-two mild-to-moderate PD patients and 54 healthy controls performed seven WM tasks tapping selective updating, continuous monitoring, or maintenance of currently active information. Self-ratings of everyday cognition, depression, and apathy symptoms, as well as screenings of global cognitive impairment, were also collected. The data were analyzed using structural equation modeling. Of the three WM domains, only selective updating was directly predictive of PD group membership. More widespread WM deficits were observed only in relation to global cognitive impairment in PD patients. Self-rated everyday cognition or psychiatric symptoms were not linked to WM performance but correlated with each other. Our findings suggest that WM has a rather limited role in the clinical manifestation of PD. Nevertheless, due to its elementary link to striatal function, the updating component of WM could be a candidate for a cognitive marker of PD also in patients who are otherwise cognitively well-preserved.
- Published
- 2020
42. Beginning of the Pandemic : COVID-19-Elicited Anxiety as a Predictor of Working Memory Performance
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Fellman, Daniel, Ritakallio, Liisa, Waris, Otto, Jylkka, Jussi, Laine, Matti, Fellman, Daniel, Ritakallio, Liisa, Waris, Otto, Jylkka, Jussi, and Laine, Matti
- Abstract
Increasing evidence indicates that the coronavirus disease 2019 (COVID-19) pandemic is associated with adverse psychological effects, including heightened levels of anxiety. This study examined whether COVID-19-related anxiety levels during the early stage of the pandemic predicted demanding working memory (WM) updating performance. Altogether, 201 healthy adults (age range, 18-50) mostly from North America and the British Isles were recruited to this study via the crowdsourcing site . The results showed that higher levels of COVID-19-related anxiety during the first weeks of the pandemic outbreak were associated with poorer WM performance as measured by the n-back paradigm. Critically, the unique role of COVID-19-related anxiety on WM could not be explained by demographic factors, or other psychological factors such as state and trait anxiety or fluid intelligence. Moreover, across three assessment points spanning 5-6 weeks, COVID-19-related anxiety levels tended to decrease over time. This pattern of results may reflect an initial psychological "shock wave" of the pandemic, the cognitive effects of which may linger for some time, albeit the initial anxiety associated with the pandemic would change with habituation and increasing information. Our results contribute to the understanding of cognitive-affective reactions to a major disaster.
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- 2020
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43. The role of strategy use in working memory training outcomes
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Fellman, Daniel, Jylkkä, Jussi, Waris, Otto, Soveri, Anna, Ritakallio, Liisa, Haga, Sarah, Salmi, Juha, Nyman, Thomas J., Laine, Matti, Fellman, Daniel, Jylkkä, Jussi, Waris, Otto, Soveri, Anna, Ritakallio, Liisa, Haga, Sarah, Salmi, Juha, Nyman, Thomas J., and Laine, Matti
- Abstract
Cognitive mechanisms underlying the limited transfer effects of working memory (WM) training remain poorly understood. We tested in detail the Strategy Mediation hypothesis, according to which WM training generates task-specific strategies that facilitate performance on the trained task and its untrained variants. This large-scale pre-registered randomized controlled trial (n = 258) used a 4-week adaptive WM training with a single digit n-back task. Strategy use was probed with open-ended strategy reports. We employed a Strategy training group (n = 73) receiving external strategy instruction, a Traditional training group (n = 118) practicing without strategy instruction, and Passive controls (n = 67). Both training groups showed emerging transfer to untrained n-back task variants already at intermediate test after 3 training sessions, extending to all untrained n-back task variants at posttest after 12 training sessions. The Strategy training group outperformed the Traditional training group only at the beginning of training, indicating short-lived strategy manipulation effects. Importantly, in the Traditional training group, strategy evolvement modulated the gains in the trained and untrained n -back tasks, supporting the Strategy Mediation hypothesis. Our results concur with the view of WM training as cognitive skill learning.
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- 2020
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44. Strategy mediation in working memory training in younger and older adults
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Forsberg, Alicia, Fellman, Daniel, Laine, Matti, Johnson, Wendy, Logie, Robert H., Forsberg, Alicia, Fellman, Daniel, Laine, Matti, Johnson, Wendy, and Logie, Robert H.
- Abstract
Working memory (WM) training with the N-Back task has been argued to improve cognitive capacity and general cognitive abilities (the Capacity Hypothesis of training), although several studies have shown little or no evidence for such improvements beyond tasks that are very similar to the trained task. Laine et al. demonstrated that instructing young adult participants to use a specific visualisation strategy for N-back training resulted in clear, generalised benefits from only 30 min of training (Strategy Mediation Hypothesis of training). Here, we report a systematic replication and extension of the Laine et al. study, by administering 60 younger and 60 older participants a set of WM tasks before and after a 30-min N-back training session. Half the participants were instructed to use a visualisation strategy, the others received no instruction. The pre-post test battery encompassed a criterion task (digit N-back), two untrained tasks N-back tasks (letters and colours), and three structurally different WM tasks. The instructed visualisation strategy significantly boosted at least some measures of N-back performance in participants of both age groups, although the strategy generally appeared more difficult to implement and less beneficial for older adults. However, the strategy did not improve performance on structurally different WM tasks. We also found significant associations between N-back performance and the type and level of detail of self-generated strategies in the uninstructed participants, as well as age group differences in reported strategy types. WM performance appeared to partly reflect the application of strategies, and Strategy Mediation should be considered to understand the mechanisms of WM training. Claims of efficient training should demonstrate useful improvement beyond task-specific strategies.
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- 2020
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45. Correction to: Bilingualism is associated with a delayed onset of dementia but not with a lower risk of developing it: A systematic review with meta-analyses
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Brini, Stefano, Sohrabi, Hamid R., Hebert, Jeffrey J., Forrest, Mitchell R. L., Laine, Matti, Hämäläinen, Heikki, Karrasch, Mira, Peiffer, Jeremiah J., Martins, Ralph N., Fairchild, Timothy J., Brini, Stefano, Sohrabi, Hamid R., Hebert, Jeffrey J., Forrest, Mitchell R. L., Laine, Matti, Hämäläinen, Heikki, Karrasch, Mira, Peiffer, Jeremiah J., Martins, Ralph N., and Fairchild, Timothy J.
- Abstract
The original version of this article unfortunately contained the following mistakes. 1. In the Results section under the paragraph Disease Severity, the sentence “The PIs ranged between -0.47 and 0.57 MMSE points” should read -0.49 and 0.59 MMSE points. 2. In Figs. 3, 5, and 7, the labels “favour bilinguals” and “favours monolinguals” should be inverted. Therefore, it should be “favours monolinguals” and “favours bilinguals”. Please see below for the correct figures. © 2020, The Author(s).
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- 2020
46. Bilingualism is associated with a delayed onset of dementia but not with a lower risk of developing it: A systematic review with meta-analyses
- Author
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Brini, Stefano, Sohrabi, Hamid R., Hebert, Jeffrey J., Forrest, Mitchell R.L., Laine, Matti, Hämäläinen, Heikki, Karrasch, Mira, Peiffer, Jeremiah, Martins, Ralph, Fairchild, Timothy J., Brini, Stefano, Sohrabi, Hamid R., Hebert, Jeffrey J., Forrest, Mitchell R.L., Laine, Matti, Hämäläinen, Heikki, Karrasch, Mira, Peiffer, Jeremiah, Martins, Ralph, and Fairchild, Timothy J.
- Abstract
Some studies have linked bilingualism with a later onset of dementia, Alzheimer’s disease (AD), and mild cognitive impairment (MCI). Not all studies have observed such relationships, however. Differences in study outcomes may be due to methodological limitations and the presence of confounding factors within studies such as immigration status and level of education. We conducted the first systematic review with meta-analysis combining cross-sectional studies to explore if bilingualism might delay symptom onset and diagnosis of dementia, AD, and MCI. Primary outcomes included the age of symptom onset, the age at diagnosis of MCI or dementia, and the risk of developing MCI or dementia. A secondary outcome included the degree of disease severity at dementia diagnosis. There was no difference in the age of MCI diagnosis between monolinguals and bilinguals [mean difference: 3.2; 95% confidence intervals (CI): −3.4, 9.7]. Bilinguals vs. monolinguals reported experiencing AD symptoms 4.7 years (95% CI: 3.3, 6.1) later. Bilinguals vs. monolinguals were diagnosed with dementia 3.3 years (95% CI: 1.7, 4.9) later. Here, 95% prediction intervals showed a large dispersion of effect sizes (−1.9 to 8.5). We investigated this dispersion with a subgroup meta-analysis comparing studies that had recruited participants with dementia to studies that had recruited participants with AD on the age of dementia and AD diagnosis between mono- and bilinguals. Results showed that bilinguals vs. monolinguals were 1.9 years (95% CI: −0.9, 4.7) and 4.2 (95% CI: 2.0, 6.4) older than monolinguals at the time of dementia and AD diagnosis, respectively. The mean difference between the two subgroups was not significant. There was no significant risk reduction (odds ratio: 0.89; 95% CI: 0.68–1.16) in developing dementia among bilinguals vs. monolinguals. Also, there was no significant difference (Hedges’ g = 0.05; 95% CI: −0.13, 0.24) in disease severity at dementia diagnosis between bilinguals and mono
- Published
- 2020
47. Accelerated long‐term forgetting over three months in asymptomatic APOE ɛ4 carriers
- Author
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Tort‐Merino, Adrià, primary, Laine, Matti, additional, Valech, Natalia, additional, Olives, Jaume, additional, León, María, additional, Ecay‐Torres, Mirian, additional, Estanga, Ainara, additional, Martínez‐Lage, Pablo, additional, Fortea, Juan, additional, Sánchez‐Valle, Raquel, additional, Rami, Lorena, additional, and Rodríguez‐Fornells, Antoni, additional
- Published
- 2020
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48. Beginning of the Pandemic: COVID-19-Elicited Anxiety as a Predictor of Working Memory Performance
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Fellman, Daniel, primary, Ritakallio, Liisa, additional, Waris, Otto, additional, Jylkkä, Jussi, additional, and Laine, Matti, additional
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- 2020
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49. Adult brain plasticity elicited by anomia treatment
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Cornelissen, Katri, Laine, Matti, Tarkiainen, Antti, Jarvensivu, Tiina, Martin, Nadine, and Salmelin, Riitta
- Subjects
Cognition -- Research ,Reading comprehension -- Research ,Methodology ,Health ,Psychology and mental health - Published
- 2003
50. GSM Mobile Phone Radiation Suppresses Brain Glucose Metabolism
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Kwon, Myoung Soo, Vorobyev, Victor, Kännälä, Sami, Laine, Matti, Rinne, Juha O, Toivonen, Tommi, Johansson, Jarkko, Teräs, Mika, Lindholm, Harri, Alanko, Tommi, and Hämäläinen, Heikki
- Published
- 2011
- Full Text
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