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4. Additional file 1 of Effect of intensive care unit-specific virtual reality (ICU-VR) to improve psychological well-being and quality of life in COVID-19 ICU survivors: a study protocol for a multicentre, randomized controlled trial

Author

Vlake, Johan H., Van Bommel, Jasper, Evert-Jan Wils, Korevaar, Tim I. M., Hellemons, Merel E., Schut, Anna F. C., Labout, Joost A. M., Schreuder, Lois L. H., Gommers, Diederik, and Van Genderen, Michel E.

Abstract

Additional file 1. Film script of the COVID-19 intensive care unit-specific virtual reality intervention.

Published
2021
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5. Natural Antibodies against Several Pneumococcal Virulence Proteins in Children during the Pre-Pneumococcal-Vaccine Era: the Generation R Study

Author

Lebon, Ankie, primary, Verkaik, Nelianne J., additional, Labout, Joost A. M., additional, de Vogel, Corné P., additional, Hooijkaas, Herbert, additional, Verbrugh, Henri A., additional, van Wamel, Willem J. B., additional, Jaddoe, Vincent W. V., additional, Hofman, Albert, additional, Hermans, Peter W. M., additional, Ma, Jiangtao, additional, Mitchell, Tim J., additional, Moll, Henriette A., additional, and van Belkum, Alex, additional

Published
2011
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10. Dynamics and Determinants of Staphylococcus aureusCarriage in Infancy: the Generation R Study

Author

Lebon, Ankie, Labout, Joost A. M., Verbrugh, Henri A., Jaddoe, Vincent W. V., Hofman, Albert, van Wamel, Willem, Moll, Henriette A., and van Belkum, Alex

Abstract

ABSTRACTSerial nasal swabs were collected at the ages of 1.5, 6, and 14 months from 443 infants in the Generation R Study. The objective was to study the dynamics and determinants of Staphylococcus aureusnasal carriage in the first year of life. The prevalence of S. aureuscarriage decreased in the first year of life, from 52.1% at the age of 1.5 months to 12.9% at 14 months. Persistent carriage, defined as continuous carriage of the same S. aureusstrain at the three sampling moments, was rarely detected in early infancy.

Published
2008
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12. Fulminant cerebral edema as a lethal manifestation of COVID-19.

Author

van den Enden AJM, van Gils L, Labout JAM, van der Jagt M, and Moudrous W

Abstract

The contribution of neurological symptomatology to morbidity and mortality after infection with Severe Acute Respiratory Syndrome-associated Coronavirus (SARS CoV II) is ill-defined. We hereby present a case of a 57-year old male patient, in excellent physical condition, who was admitted to the Intensive Care Unit (ICU), with respiratory distress duo to SARS CoV II-induced bilateral pneumonia. After 2 weeks at the ICU, with respiratory conditions improving, the patient developed lethal cerebral edema. This case advocates regular wake-up calls in Coronavirus disease 2019 patients for neurological (radiological) evaluation to provide rapid diagnosis and a therapeutic window for fulminant central nervous system complications., (© 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)

Published
2020
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13. Association of perioperative troponin and atrial fibrillation after coronary artery bypass grafting.

Author

Koolen BB, Labout JA, Mulder PG, Gerritse BM, Rijpstra TA, Bentala M, Rosseel PM, and van der Meer NJ

Subjects
Aged, Atrial Fibrillation diagnosis, Atrial Fibrillation etiology, Biomarkers blood, Cardiotonic Agents therapeutic use, Female, Humans, Length of Stay, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Atrial Fibrillation blood, Coronary Artery Bypass adverse effects, Troponin T blood
Abstract

Objectives: Prediction of atrial fibrillation (AF) after coronary artery bypass grafting (CABG) may lead to preventive or early treatment and improved outcome. We investigated the association of serial perioperative cardiac troponin T (cTNT) measurements with postoperative AF in patients undergoing CABG., Methods: In a retrospective analysis of prospectively collected data, 3148 patients undergoing elective CABG were evaluated. cTNT values were routinely determined before the start of surgery (cTNT0), at arrival on the intensive care unit (cTNT1) and 8-12 h later (cTNT2). Measurement of cTNT was continued until the peak value was reached. The development of AF during hospital stay was scored. The association between cTNT (cTNT0, cTNT1, cTNT2 and cTNTmax in first 48 h) and AF was calculated in univariable and multivariable analysis., Results: AF occurred in 1080 (34%) patients. cTNT0, cTNT2 and cTNTmax were significantly and positively associated with postoperative AF (P < 0.001) in a univariable analysis, whereas a trend was seen for cTNT1 (P = 0.051). Advanced age, inotropic support and postoperative infection were independently associated with postoperative AF after logistic regression analysis, but cTNT was not. Categorizing patients by inotropic support into categories of inotropic support duration (none, <48 h, >48 h), the mean cTNT values were significantly higher among patients with AF in each category (all P < 0.001). Perioperative cTNT was significantly higher in patients with postoperative complications, longer hospital stay and reduced in-hospital survival., Conclusions: Perioperative cTNT is univariably associated with postoperative AF after CABG, but not independently. Further, no clinically useful cut-off point for preventive or early treatment could be identified. Both perioperative cTNT and postoperative AF are associated with negative outcome and prolonged hospital stay.

Published
2013
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