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Your search keyword '"Kurihara, Tatsuya"' showing total 22 results
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22 results on '"Kurihara, Tatsuya"'

1. Dwarfism and Early Death in Mice Lacking C-Type Natriuretic Peptide

Author

Chusho, Hideki, Tamura, Naohisa, Ogawa, Yoshihiro, Yasoda, Akihiro, Suda, Michio, Miyazawa, Takashi, Nakamura, Kenji, Nakao, Kazuki, Kurihara, Tatsuya, Komatsu, Yasato, Itoh, Hiroshi, Tanaka, Kiyoshi, Saito, Yoshihiko, Katsuki, Motoya, and Nakao, Kazuwa

Published
2001

7. Identification of factors associated with the efficacy of atomoxetine in adult attention‐deficit/hyperactivity disorder.

Author

Nagai, Tsutomu, Kurihara, Tatsuya, Koya, Hiroaki, Nakano, Yukako, Sugisawa, Satoru, Sambe, Takehiko, Kishimoto, Keiko, Kogo, Mari, Ota, Haruhisa, Iwanami, Akira, and Uchida, Naoki

Abstract

Aim: Atomoxetine (ATX) is a non‐central stimulant and a standard treatment for adult attention‐deficit/hyperactivity disorder (ADHD). The long‐term efficacy of Atomoxetine is about 40% at 6 months. The variability in efficacy between individuals is thought to be related to patient‐specific factors, but no detailed research has been conducted. In this retrospective cohort study, we aimed to identify the factors associated with Atomoxetine efficacy. Methods: A total of 147 patients with attention‐deficit/hyperactivity disorder aged ≥18 years who were using Atomoxetine for the first time were included in this study. The outcome was treatment success (treatment maintained for at least 6 months and improvement in symptoms). Symptom assessment was based on the overall improvement in symptoms judged by an expert physician. Results: Of the patient sample, 103 (70.1%) achieved the outcome. Logistic regression analysis identified "the maximum dose of ATX" and "gambling habit" as factors associated with efficacy (P < 0.05). In the process of Atomoxetine titration, the larger the maximum dose, the higher the efficacy was shown to be. Gambling habits may be indicative of impulsivity, which is among the core symptoms of attention‐deficit/hyperactivity disorder. Thus, a gambling habit may be considered a surrogate marker for impulsivity. Conclusions: Knowledge of these factors will help healthcare professionals to predict the likely efficacy of Atomoxetine in a given patient before subscribing it, facilitating individualized pharmacotherapy for adult attention‐deficit/hyperactivity disorder. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway

Author

Yasoda, Akihiro, Komatsu, Yasato, Chusho, Hideki, Miyazawa, Takashi, Ozasa, Ami, Miura, Masako, Kurihara, Tatsuya, Rogi, Tomohiro, Tanaka, Shoji, Suda, Michio, Tamura, Naohisa, Ogawa, Yoshihiro, and Nakao, Kazuwa

Abstract

Achondroplasia is the most common genetic form of human dwarfism, for which there is presently no effective therapy. C-type natriuretic peptide (CNP) is a newly identified molecule that regulates endochondral bone growth through GC-B, a subtype of particulate guanylyl cyclase. Here we show that targeted overexpression of CNP in chondrocytes counteracts dwarfism in a mouse model of achondroplasia with activated fibroblast growth factor receptor 3 (FGFR-3) in the cartilage. CNP prevented the shortening of achondroplastic bones by correcting the decreased extracellular matrix synthesis in the growth plate through inhibition of the MAPK pathway of FGF signaling. CNP had no effect on the STAT-1 pathway of FGF signaling that mediates the decreased proliferation and the delayed differentiation of achondroplastic chondrocytes. These results demonstrate that activation of the CNP-GC-B system in endochondral bone formation constitutes a new therapeutic strategy for human achondroplasia., Author(s): Akihiro Yasoda [1]; Yasato Komatsu [1]; Hideki Chusho [1]; Takashi Miyazawa [1]; Ami Ozasa [1]; Masako Miura [1]; Tatsuya Kurihara [2]; Tomohiro Rogi [2]; Shoji Tanaka [2]; Michio Suda [...]

Published
2004
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15. Oral Administration of Heat-KilledLactobacillus plantarumStrain b240 Protected Mice againstSalmonella entericaSerovar Typhimurium

Author

ISHIKAWA, Hiroki, primary, KUTSUKAKE, Etsuko, additional, FUKUI, Toshie, additional, SATO, Ikutaro, additional, SHIRAI, Toshiaki, additional, KURIHARA, Tatsuya, additional, OKADA, Nobuhiko, additional, DANBARA, Hirofumi, additional, TOBA, Masamichi, additional, KOHDA, Noriyuki, additional, MAEDA, Yasuyuki, additional, and MATSUMOTO, Tetsuya, additional

Published
2010
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16. Central Role of Calcium-Dependent Tyrosine Kinase PYK2 in Endothelial Nitric Oxide Synthase–Mediated Angiogenic Response and Vascular Function

Author

Matsui, Akihiro, primary, Okigaki, Mitsuhiko, additional, Amano, Katsuya, additional, Adachi, Yasushi, additional, Jin, Denan, additional, Takai, Shinji, additional, Yamashita, Tomoya, additional, Kawashima, Seinosuke, additional, Kurihara, Tatsuya, additional, Miyazaki, Mizuo, additional, Tateishi, Kento, additional, Matsunaga, Shinsaku, additional, Katsume, Asako, additional, Honshou, Shoken, additional, Takahashi, Tomosaburo, additional, Matoba, Satoaki, additional, Kusaba, Tetsuro, additional, Tatsumi, Tetsuya, additional, and Matsubara, Hiroaki, additional

Published
2007
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17. Overexpression of Mitochondrial Peroxiredoxin-3 Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

Author

Matsushima, Shouji, primary, Ide, Tomomi, additional, Yamato, Mayumi, additional, Matsusaka, Hidenori, additional, Hattori, Fumiyuki, additional, Ikeuchi, Masaki, additional, Kubota, Toru, additional, Sunagawa, Kenji, additional, Hasegawa, Yasuhiro, additional, Kurihara, Tatsuya, additional, Oikawa, Shinzo, additional, Kinugawa, Shintaro, additional, and Tsutsui, Hiroyuki, additional

Published
2006
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18. Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway

Author

Yasoda, Akihiro, primary, Komatsu, Yasato, additional, Chusho, Hideki, additional, Miyazawa, Takashi, additional, Ozasa, Ami, additional, Miura, Masako, additional, Kurihara, Tatsuya, additional, Rogi, Tomohiro, additional, Tanaka, Shoji, additional, Suda, Michio, additional, Tamura, Naohisa, additional, Ogawa, Yoshihiro, additional, and Nakao, Kazuwa, additional

Published
2003
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19. Purification, cDNA Cloning, and Characterization of a New Serpin with Megakaryocyte Maturation Activity

Author

Tsujimoto, Masafumi, primary, Tsuruoka, Nobuo, additional, Ishida, Nobuhiro, additional, Kurihara, Tatsuya, additional, Iwasa, Fuyuki, additional, Yamashiro, Kyoko, additional, Rogi, Tomohiro, additional, Kodama, Shiho, additional, Katsuragi, Naruto, additional, Adachi, Mayumi, additional, Katayama, Toyoko, additional, Nakao, Masahiro, additional, Yamaichi, Kozo, additional, Hashino, Junko, additional, Haruyama, Munetada, additional, Miura, Kenju, additional, Nakanishi, Toshihiro, additional, Nakazato, Hiroshi, additional, Teramura, Masanao, additional, Mizoguchi, Hideaki, additional, and Yamaguchi, Nozomi, additional

Published
1997
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21. Oral Administration of Heat-Killed Lactobacillus plantarum Strain b240 Protected Mice against Salmonella enterica Serovar Typhimurium.

Author

Ishikawa, Hiroki, Kutsukake, Etsuko, Fukui, Toshie, Sato, Ikutaro, Shirai, Toshiaki, Kurihara, Tatsuya, Okada, Nobuhiko, Danbara, Hirofumi, Toba, Masamichi, Kohda, Noriyuki, Maeda, Yasuyuki, and Matsumoto, Tetsuya

Subjects
LACTOBACILLUS plantarum, PROBIOTICS, SALMONELLA diseases, LABORATORY mice, PATHOGENIC microorganisms, PREVENTION
Abstract

The article presents a study which seeks to investigate the effects of heat-killed Lactobacillus plantarum stari b240 (b240) against Salmonella enterica serovar tymphimurium. Results of the study show that mice treated with b240 were protected against S. Typhimurium compared to the mice fed with salien. The study concludes that nonviable lactic acid bacteria play significant roles in preventing infection by enteric pathogens.

Published
2010
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22. Oral Administration of Heat-Killed Lactobacillus plantarumStrain b240 Protected Mice against Salmonella entericaSerovar Typhimurium

Author

ISHIKAWA, Hiroki, KUTSUKAKE, Etsuko, FUKUI, Toshie, SATO, Ikutaro, SHIRAI, Toshiaki, KURIHARA, Tatsuya, OKADA, Nobuhiko, DANBARA, Hirofumi, TOBA, Masamichi, KOHDA, Noriyuki, MAEDA, Yasuyuki, and MATSUMOTO, Tetsuya

Abstract

The purpose of this study was to investigate the effects of heat-killed Lactobacillus plantarumstrain b240 (b240) on systemic infection by Salmonella entericaserovar Typhimurium (S.Typhimurium) and to determine the mechanism by which b240 protects against infection. Mice were administered either b240 or saline orally for 3 weeks, and then inoculated with S.Typhimurium. The mice treated with b240 were significantly protected against S.Typhimurium as compared to those fed saline. Moreover, translocation of S.Typhimurium into each organ tested in the mice that received b240 tended to be less than in the control mice. An important mechanism of protection against infection was demonstrated by the ability of b240 to inhibit both binding by and invasion of S.Typhimurium into cells. These results indicate that nonviable lactic acid bacteria also play important roles in preventing infection by enteric pathogens.

Published
2010
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