Search

Your search keyword '"Kuhner A"' showing total 489 results
Start Over Author "Kuhner A" Search Limiters Full Text
489 results on '"Kuhner A"'

2. Accumulation of Epstein-Barr virus-induced cross-reactive immune responses is associated with multiple sclerosis

Author

Vietzen, Hannes, Kuhner, Laura M., Berger, Sarah M., Furlano, Philippe L., Bsteh, Gabriel, Berger, Thomas, Rommer, Paulus, and Puchhammer-Stockl, Elisabeth

Subjects
Complications and side effects, Development and progression, Research, Cross reactions (Immunology) -- Research, Immunologic research, Epstein-Barr virus diseases -- Complications and side effects, Immune response -- Research, Multiple sclerosis -- Development and progression, Immunological research
Abstract

To the Editor: Multiple sclerosis (MS) is a chronic autoinflammatory and demyelinating disease of the central nervous system (CNS). The individual risk of developing MS substantially increases after a primary [...]

Published
2024

4. Species and origin determinations of an ivory chess set: An application of the ivory workflow implemented by California’s Wildlife Forensic Laboratory

Author

Kelly L. Carrothers, Nicole M. Slattengren, Mary K. Kuhner, Thomas A. Brown, and Ashley M. Spicer

Subjects
Ivory, Elephant, Forensic, DNA, Isotope, Origin assignment, Ecology, QH540-549.5, Veterinary medicine, SF600-1100
Abstract

Despite the prevalence of elephant poaching and ivory trafficking, domestic and international ivory markets around the world are slowly closing due to increased education and enforcement efforts. This includes California’s ivory market in 2016 after the passage of Assembly Bill 96 (AB 96), which prohibits the purchase, sale, offer for sale, possession, or importation with intent to sell, of ivory from elephant, mammoth, and mastodon along with other non-proboscidean species. To assist with enforcement efforts, the California Department of Fish and Wildlife’s Wildlife Forensic Laboratory (CDFW-WFL) has created and implemented a scientific workflow to taxonomically identify, geographically assign, and age California’s seized ivory. Here we discuss the application of this scientific workflow to a 32-piece ivory chess set, which was purchased in 1969 and donated to and examined by the WFL in 2021. Genetic data revealed 11 unique haplotypes and 19 unique genotypes, suggesting a diverse set of African elephants from numerous locations in Africa were used to assemble the chess set. Stable isotope data corroborated these findings and radiocarbon dating suggested the ivory used to carve these chess pieces grew approximately 6 years prior to the chess set being purchased. Our results indicate that the use of a variety of scientific techniques provides a wide scope of information; furthermore, taxonomically identifying, geographically assigning, and aging the ivory chess set demonstrates to law enforcement officers how our ivory workflow can assist them in coordinating efforts locally, nationally, and internationally to help stop the illegal importation of ivory into California.

Published
2024
Full Text
View/download PDF

5. THE MEN BEHIND THE MET

Author

Kuhner, John Byron

Subjects
Gas utilities, Philosophy and religion, Metropolitan Museum of Art
Abstract

MY GRANDFATHER died before I was born, and he remains to me a mostly mysterious figure. As is true of many people born poor who are committed to bettering their [...]

Published
2023

6. ANGEL OF NEW YORK

Author

Kuhner, John Byron

Subjects
Central Park, New York, New York -- Social aspects, Philosophy and religion
Abstract

On days when the world to me is desolation; when I cannot sit in my seat, or do any productive labor; when I have a terrible desire to be free, [...]

Published
2023

8. Medical students experience mistreatment, with a focus on gender discrimination. Cross-sectional study at one Swedish medical school

Author

Marta A. Kisiel, Anna Rask-Andersen, Sofia Kuhner, Xing Wu Zhou, Martin Wohlin, Susann J. Järhult, and Christer Janson

Subjects
mistreatment of medical students, gender discrimination, Swedish medical school, Social Sciences
Abstract

AbstractThe aim was to study discrimination, with a focus on gender and sexual harassment among medical students at Uppsala University in Sweden. A survey was sent via email to all registered medical students in the spring semester of 2020. Data were compared with two previous studies. Questions about gender and sexual harassment were the same as in the study conducted in 2002 and 2013. In addition, the 2020 survey included a question about other grounds of discrimination. Forty percent, that is, 453 out of 1,130 medical students, participated. The proportion of students reporting gender-based discrimination during the preclinical semesters was similar for females and males. During the clinical semesters, significantly more females than males reported gender discrimination (41% vs. 21.5%, p = 0.005) and sexual harassment (22% vs. 5%, p = 0.001). Physicians were the most commonly reported perpetrator. Reports about not being respected had increased from 2% to 20% between 2013 and 2020 among female clinical students. The prevalence of those who experienced several sexually harassing behaviors increased for the female and male clinical students and the female preclinical students. Receiving an unwelcome touch increased from 1% to 7% for the female clinical students. Discrimination due to ethnicity was reported by 36% of the students born in a country other than Sweden compared to 3% of those born in Sweden. Our findings confirm that experiences of different forms of discrimination exist in this medical school, and females and minorities are particularly affected.

Published
2023
Full Text
View/download PDF

9. Acting Thoughts: Towards a Mobile Robotic Service Assistant for Users with Limited Communication Skills

Author

Burget, Felix, Fiederer, Lukas Dominique Josef, Kuhner, Daniel, Völker, Martin, Aldinger, Johannes, Schirrmeister, Robin Tibor, Do, Chau, Boedecker, Joschka, Nebel, Bernhard, Ball, Tonio, and Burgard, Wolfram

Subjects
Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Human-Computer Interaction, Computer Science - Learning, Computer Science - Robotics, I.2.4, I.2.6, I.2.8, I.2.9, I.2.10, I.4.8, I.5.1
Abstract

As autonomous service robots become more affordable and thus available also for the general public, there is a growing need for user friendly interfaces to control the robotic system. Currently available control modalities typically expect users to be able to express their desire through either touch, speech or gesture commands. While this requirement is fulfilled for the majority of users, paralyzed users may not be able to use such systems. In this paper, we present a novel framework, that allows these users to interact with a robotic service assistant in a closed-loop fashion, using only thoughts. The brain-computer interface (BCI) system is composed of several interacting components, i.e., non-invasive neuronal signal recording and decoding, high-level task planning, motion and manipulation planning as well as environment perception. In various experiments, we demonstrate its applicability and robustness in real world scenarios, considering fetch-and-carry tasks and tasks involving human-robot interaction. As our results demonstrate, our system is capable of adapting to frequent changes in the environment and reliably completing given tasks within a reasonable amount of time. Combined with high-level planning and autonomous robotic systems, interesting new perspectives open up for non-invasive BCI-based human-robot interactions., Comment: * FB, LDJF, DK, MV and JA contributed equally to the work. Accepted as a conference paper at the European Conference on Mobile Robotics 2017 (ECMR 2017), 6 pages, 3 figures

Published
2017
Full Text
View/download PDF

10. Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression

Author

Thomas G. Paulson, Patricia C. Galipeau, Kenji M. Oman, Carissa A. Sanchez, Mary K. Kuhner, Lucian P. Smith, Kevin Hadi, Minita Shah, Kanika Arora, Jennifer Shelton, Molly Johnson, Andre Corvelo, Carlo C. Maley, Xiaotong Yao, Rashesh Sanghvi, Elisa Venturini, Anne-Katrin Emde, Benjamin Hubert, Marcin Imielinski, Nicolas Robine, Brian J. Reid, and Xiaohong Li

Subjects
Science
Abstract

Barrett’s esophagus is a pre-malignant condition that can progress to esophageal cancer. Here, the authors carry out whole genome sequencing of samples from patients who did or did not progress to cancer and find that mutations in many genes occur regardless of progression status, but also find features associated with progressive disease.

Published
2022
Full Text
View/download PDF

11. The Enduring Appeal of J.R.R. Tolkien: What explains his unique and lasting success?

Author

Kuhner, John Byron

Subjects
Tolkien's Faith (Biography) -- Criticism and interpretation, Authors -- Portrayals -- Evaluation -- Works, Political science
Abstract

The year 2023 marked 50 years since the death of John Ronald Reuel Tolkien, and 2024 will mark 70 years since the publication of the first volume of The Lord [...]

Published
2024

14. Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

Author

Hadi, Kevin, Yao, Xiaotong, Behr, Julie M., Deshpande, Aditya, Xanthopoulakis, Charalampos, Tian, Huasong, Kudman, Sarah, Rosiene, Joel, Darmofal, Madison, DeRose, Joseph, Mortensen, Rick, Adney, Emily M., Shaiber, Alon, Gajic, Zoran, Sigouros, Michael, Eng, Kenneth, Wala, Jeremiah A., Wrzeszczyński, Kazimierz O., Arora, Kanika, Shah, Minita, Emde, Anne-Katrin, Felice, Vanessa, Frank, Mayu O., Darnell, Robert B., Ghandi, Mahmoud, Huang, Franklin, Dewhurst, Sally, Maciejowski, John, de Lange, Titia, Setton, Jeremy, Riaz, Nadeem, Reis-Filho, Jorge S., Powell, Simon, Knowles, David A., Reznik, Ed, Mishra, Bud, Beroukhim, Rameen, Zody, Michael C., Robine, Nicolas, Oman, Kenji M., Sanchez, Carissa A., Kuhner, Mary K., Smith, Lucian P., Galipeau, Patricia C., Paulson, Thomas G., Reid, Brian J., Li, Xiaohong, Wilkes, David, Sboner, Andrea, Mosquera, Juan Miguel, Elemento, Olivier, and Imielinski, Marcin

Published
2020
Full Text
View/download PDF

15. Sinead O'Connor's Cross

Author

Byron Kuhner, John

Subjects
Parenting, Philosophy and religion
Abstract

SINEAD O'CONNOR, THE troubled Irish singer-songwriter, died in July at age fifty-six. No cause of death has been announced, but it is fair to note that at times she both [...]

Published
2023

16. Within‐patient phylogenetic reconstruction reveals early events in Barrett’s Esophagus

Author

Lucian P. Smith, Jon A. Yamato, Patricia C. Galipeau, Thomas G. Paulson, Xiaohong Li, Carissa A. Sanchez, Brian J. Reid, and Mary K. Kuhner

Subjects
ARID1A, Barrett's Esophagus, CDKN2A, esophageal adenocarcinoma, genome doubling, phylogeny, Evolution, QH359-425
Abstract

Abstract Barrett's Esophagus is a neoplastic condition which progresses to esophageal adenocarcinoma in 5% of cases. Key events affecting the outcome likely occur before diagnosis of Barrett's and cannot be directly observed; we use phylogenetic analysis to infer such past events. We performed whole‐genome sequencing on 4–6 samples from 40 cancer outcome and 40 noncancer outcome patients with Barrett's Esophagus, and inferred within‐patient phylogenies of deconvoluted clonal lineages. Spatially proximate lineages clustered in the phylogenies, but temporally proximate ones did not. Lineages with inferred loss‐of‐function mutations in both copies of TP53 and CDKN2A showed enhanced spatial spread, whereas lineages with loss‐of‐function mutations in other frequently mutated loci did not. We propose a two‐phase model with expansions of TP53 and CKDN2A mutant lineages during initial growth of the segment, followed by relative stasis. Subsequent to initial expansion, mutations in these loci as well as ARID1A and SMARCA4 may show a local selective advantage but do not expand far: The spatial structure of the Barrett's segment remains stable during surveillance even in patients who go on to cancer. We conclude that the cancer/noncancer outcome is strongly affected by early steps in formation of the Barrett's segment.

Published
2021
Full Text
View/download PDF

17. 'Like a ticking time bomb': the persistence of trauma in the HIV diagnosis experience among black men who have sex with men in New York City

Author

Ofole Mgbako, Ellen Benoit, Nishanth S. Iyengar, Christopher Kuhner, Dustin Brinker, and Dustin T. Duncan

Subjects
Black, MSM, African-American, HIV, Trauma, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Black men who have sex with men (MSM) are disproportionately affected by HIV compared to almost every other demographic group in the country and have worse outcomes along the care continuum. Diagnosis is a critical juncture. This study aims to explore the impact and meaning of an HIV diagnosis for Black MSM, and how this has changed over time, both for the individual’s experience living with HIV as well as for Black MSM in general. Methods From 2017 to 2018, we conducted in-depth interviews with 16 black MSM living with HIV in New York City diagnosed between 1985 and 2016. Results Inductive analysis of the qualitative data allowed three major themes to emerge: diagnosis trauma, lack of patient -centeredness in the healthcare system, and acceptance of HIV diagnosis over time. Conclusions This small pilot study signals that an HIV diagnosis experience possibly remains traumatic for black MSM even in the era of highly effective ART, and they often perceive a lack of patient-centeredness in the delivery of a new diagnosis. This has persisted over time. In most cases, black MSM in our sample overcame this trauma due to self-motivation, social support and seeking out and fostering trusting relationships with their HIV provider and the healthcare system.

Published
2020
Full Text
View/download PDF

18. Factors Associated With Hospitalization or Intensive Care Admission in Children With COVID-19 in Latin America

Author

Eduardo López-Medina, German Camacho-Moreno, Martin E. Brizuela, Diana M. Dávalos, Juan Pablo Torres, Rolando Ulloa-Gutierrez, Pio López, Roberto Debbag, Paola Pérez, Jaime Patiño, Ximena Norero, Cristina Mariño, Miguel A. Luengas, Gabriela Ensinck, Carlos Daza, Kathia Luciani, Paola Quintana Kuhner, Mónica Rodriguez, Juan Pablo Rodríguez-Auad, Alejandra Estrada-Villarroel, Mayli Carnevale, Orlando Cesar Mantese, Eitan N. Berezin, José Iván Castillo, Abiel Mascareñas, Andrea Jimenez-Zambrano, Lourdes Dueñas, Mario Melgar, Nancy Galvez, Erika Cantor, and Edwin J. Asturias

Subjects
COVID-19, SARS-CoV-2, children, critical care, hospitalization, Pediatrics, RJ1-570
Abstract

BackgroundLimited data is available from low-middle and upper-middle income countries of the factors associated with hospitalization or admission to pediatric intensive care unit (PICU) for children with COVID-19.ObjectiveTo describe the factors associated with hospitalization or PICU admission of children with COVID-19 in Latin America.MethodMulticenter, analytical, retrospective study of children reported from 10 different Latin American countries to the Latin-American Society of Pediatric Infectious Diseases (SLIPE-COVID) research network from June 1, 2020, and February 28, 2021. Outpatient or hospitalized children

Published
2022
Full Text
View/download PDF

19. The Eternal Debate Over Conservatism and Prudence: A Historical Perspective on the Conceptualization of Asymmetry in Financial Accounting Theory.

Author

ORTHAUS, SELINA, PELGER, CHRISTOPH, and KUHNER, CHRISTOPH

Subjects
ACCOUNTING, PRUDENCE, CONSERVATISM, CONSERVATISM (Accounting), FINANCIAL statements, ENGINEERING standards
Abstract

Copyright of Contemporary Accounting Research is the property of Canadian Academic Accounting Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
Full Text
View/download PDF

21. 'The Perspective of the Acting Person' and Moral Action: Reading Veritatis Splendor no. 78 with Servais Pinckaers, O.P.

Author

Matthew Kuhner

Subjects
Moral theology, BV4625-4780
Abstract

This article addresses one of the most significant and memorable concepts in John Paul II’s encyclical on the Catholic Church’s moral teaching, _Veritatis Splendor_, namely, the necessity to place oneself in “the perspective of the acting person” for a proper understanding of moral action. Part One of the paper examines an article by Servais Pinckaers, O.P. on Thomistic action theory. I argue that this rich contribution provides theological and moral bases for the concept of “the perspective of the acting person” and the importance of the end (finis) in the assessment in moral action. Part Two offers a line-by-line commentary on no. 78 of _Veritatis Splendor_, the very heart of the encyclical’s discussion of human action. In dialogue with other commentators, I propose a reading of the paragraph set against the landscape of action theory proposed by Pinckaers. In light of this commentary, I suggest that Pinckaers understanding of Thomistic action theory affords a hermeneutical key for “the perspective of the acting person” that cannot be set aside without cost.

Published
2021

25. NSAID use and somatic exomic mutations in Barrett’s esophagus

Author

Patricia C. Galipeau, Kenji M. Oman, Thomas G. Paulson, Carissa A. Sanchez, Qing Zhang, Jerry A. Marty, Jeffrey J. Delrow, Mary K. Kuhner, Thomas L. Vaughan, Brian J. Reid, and Xiaohong Li

Subjects
Exome sequencing, Mutation, Apoptosis, Barrett’s esophagus, Esophageal adenocarcinoma, Aspirin, Medicine, Genetics, QH426-470
Abstract

Abstract Background Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the metaplastic condition Barrett’s esophagus (BE) and to lower the incidence and mortality of esophageal adenocarcinoma (EA). The esophagus is exposed to both intrinsic and extrinsic mutagens resulting from gastric reflux, chronic inflammation, and exposure to environmental carcinogens such as those found in cigarettes. Here we test the hypothesis that NSAID use inhibits accumulation of point mutations/indels during somatic genomic evolution in BE. Methods Whole exome sequences were generated from 82 purified epithelial biopsies and paired blood samples from a cross-sectional study of 41 NSAID users and 41 non-users matched by sex, age, smoking, and continuous time using or not using NSAIDs. Results NSAID use reduced overall frequency of point mutations across the spectrum of mutation types, lowered the frequency of mutations even when adjusted for both TP53 mutation and smoking status, and decreased the prevalence of clones with high variant allele frequency. Never smokers who consistently used NSAIDs had fewer point mutations in signature 17, which is commonly found in EA. NSAID users had, on average, a 50% reduction in functional gene mutations in nine cancer-associated pathways and also had less diversity in pathway mutational burden compared to non-users. Conclusions These results indicate NSAID use functions to limit overall mutations on which selection can act and supports a model in which specific mutant cell populations survive or expand better in the absence of NSAIDs.

Published
2018
Full Text
View/download PDF

26. Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

Author

Pierre Martinez, Diego Mallo, Thomas G. Paulson, Xiaohong Li, Carissa A. Sanchez, Brian J. Reid, Trevor A. Graham, Mary K. Kuhner, and Carlo C. Maley

Subjects
Science
Abstract

Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy genetic diversity.

Published
2018
Full Text
View/download PDF

28. Motion Biomarkers Showing Maximum Contrast Between Healthy Subjects and Parkinson's Disease Patients Treated With Deep Brain Stimulation of the Subthalamic Nucleus. A Pilot Study

Author

Andreas Kuhner, Isabella Katharina Wiesmeier, Massimo Cenciarini, Timo Leon Maier, Stefan Kammermeier, Volker Arnd Coenen, Wolfram Burgard, and Christoph Maurer

Subjects
Parkinson's disease, machine learning, motion, algorithm, accelerometry, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Classic motion abnormalities in Parkinson's disease (PD), such as tremor, bradykinesia, or rigidity, are well-covered by standard clinical assessments such as the Unified Parkinson's Disease Rating Scale (UPDRS). However, PD includes motor abnormalities beyond the symptoms and signs as measured by UPDRS, such as the lack of anticipatory adjustments or compromised movement smoothness, which are difficult to assess clinically. Moreover, PD may entail motor abnormalities not yet known. All these abnormalities are quantifiable via motion capture and may serve as biomarkers to diagnose and monitor PD.Objective: In this pilot study, we attempted to identify motion features revealing maximum contrast between healthy subjects and PD patients with deep brain stimulation (DBS) of the nucleus subthalamicus (STN) switched off and on as the first step to develop biomarkers for detecting and monitoring PD patients' motor symptoms.Methods: We performed 3D gait analysis in 7 out of 26 PD patients with DBS switched off and on, and in 25 healthy control subjects. We computed feature values for each stride, related to 22 body segments, four time derivatives, left–right mean vs. difference, and mean vs. variance across stride time. We then ranked the feature values according to their distinguishing power between PD patients and healthy subjects.Results: The foot and lower leg segments proved better in classifying motor anomalies than any other segment. Higher degrees of time derivatives were superior to lower degrees (jerk > acceleration > velocity > displacement). The averaged movements across left and right demonstrated greater distinguishing power than left–right asymmetries. The variability of motion was superior to motion's absolute values.Conclusions: This small pilot study identified the variability of a smoothness measure, i.e., jerk of the foot, as the optimal signal to separate healthy subjects' from PD patients' gait. This biomarker is invisible to clinicians' naked eye and is therefore not included in current motor assessments such as the UPDRS. We therefore recommend that more extensive investigations be conducted to identify the most powerful biomarkers to characterize motor abnormalities in PD. Future studies may challenge the composition of traditional assessments such as the UPDRS.

Published
2020
Full Text
View/download PDF

29. Experimental confirmation of efficient island divertor operation and successful neoclassical transport optimization in Wendelstein 7-X

Author

Pedersen, T, Abramovic, I, Agostinetti, P, Torres, M, Akaslompolo, S, Belloso, J, Aleynikov, P, Aleynikova, K, Alhashimi, M, Ali, A, Allen, N, Alonso, A, Anda, G, Andreeva, T, Angioni, C, Arkhipov, A, Arnold, A, Asad, W, Ascasibar, E, Aumeunier, M, Avramidis, K, Aymerich, E, Baek, S, Bahner, J, Baillod, A, Balden, M, Baldzuhn, J, Ballinger, S, Banduch, M, Bannmann, S, Navarro, A, Barbui, T, Beidler, C, Belafdil, C, Bencze, A, Benndorf, A, Beurskens, M, Biedermann, C, Biletskyi, O, Blackwell, B, Blatzheim, M, Bluhm, T, Bockenhoff, D, Bongiovi, G, Borchardt, M, Borodin, D, Boscary, J, Bosch, H, Bosmann, T, Boswirth, B, Bottger, L, Bottino, A, Bozhenkov, S, Brakel, R, Brandt, C, Brauer, T, Braune, H, Brezinsek, S, Brunner, K, Buller, S, Burhenn, R, Bussiahn, R, Buttenschon, B, Buzas, A, Bykov, V, Calvo, I, Mata, K, Caminal, I, Cannas, B, Cappa, A, Carls, A, Carovani, F, Carr, M, Carralero, D, Carvalho, B, Casas, J, Castano-Bardawil, D, Castejon, F, Chaudhary, N, Chelis, I, Chomiczewska, A, Coenen, J, Cole, M, Cordella, F, Corre, Y, Crombe, K, Cseh, G, Csillag, B, Damm, H, Day, C, de Baar, M, De la Cal, E, Degenkolbe, S, Demby, A, Denk, S, Dhard, C, Di Siena, A, Dinklage, A, Dittmar, T, Dreval, M, Drevlak, M, Drewelow, P, Drews, P, Dunai, D, Edlund, E, Effenberg, F, Ehrke, G, Endler, M, Ennis, D, Escoto, F, Estrada, T, Fable, E, Fahrenkamp, N, Fanni, A, Faustin, J, Fellinger, J, Feng, Y, Figacz, W, Flom, E, Ford, O, Fornal, T, Frerichs, H, Freundt, S, Fuchert, G, Fukuyama, M, Fullenbach, F, Gantenbein, G, Gao, Y, Garcia, K, Regana, J, Garcia-Cortes, I, Gaspar, J, Gates, D, Geiger, J, Geiger, B, Giudicotti, L, Gonzalez, A, Goriaev, A, Gradic, D, Grahl, M, Graves, J, Green, J, Grelier, E, Greuner, H, Gross, S, Grote, H, Groth, M, Gruca, M, Grulke, O, Grun, M, Arnaiz, J, Gunter, S, Haak, V, Haas, M, Hacker, P, Hakola, A, Hallenbert, A, Hammond, K, Han, X, Hansen, S, Harris, J, Hartfuss, H, Hartmann, D, Hathiramani, D, Hatzky, R, Hawke, J, Hegedus, S, Hein, B, Heinemann, B, Helander, P, Henneberg, S, Hergenhahn, U, Hidalgo, C, Hindenlang, F, Hirsch, M, Hofel, U, Hollfeld, K, Holtz, A, Hopf, D, Hoschen, D, Houry, M, Howard, J, Huang, X, Hubeny, M, Hudson, S, Ida, K, Igitkhanov, Y, Igochine, V, Illy, S, Ionita-Schrittwieser, C, Isobe, M, Jablczynska, M, Jablonski, S, Jagielski, B, Jakubowski, M, van Vuuren, A, Jelonnek, J, Jenko, F, Jensen, T, Jenzsch, H, Junghanns, P, Kaczmarczyk, J, Kallmeyer, J, Kamionka, U, Kandler, M, Kasilov, S, Kazakov, Y, Kennedy, D, Kharwandikar, A, Khokhlov, M, Kiefer, C, Killer, C, Kirschner, A, Kleiber, R, Klinger, T, Klose, S, Knauer, J, Knieps, A, Kochl, F, Kocsis, G, Kolesnichenko, Y, Konies, A, Konig, R, Kontula, J, Kornejew, P, Koschinsky, J, Kozulia, M, Kramer-Flecken, A, Krampitz, R, Krause, M, Krawczyk, N, Kremeyer, T, Krier, L, Kriete, D, Krychowiak, M, Ksiazek, I, Kubkowska, M, Kuczynski, M, Kuhner, G, Kumar, A, Kurki-Suonio, T, Kwak, S, Landreman, M, Lang, P, Langenberg, A, Laqua, H, Laube, R, Lazerson, S, Lewerentz, M, Li, C, Liang, Y, Linsmeier, C, Lion, J, Litnovsky, A, Liu, S, Lobsien, J, Loizu, J, Lore, J, Lorenz, A, Losada, U, Louche, F, Lunsford, R, Lutsenko, V, Machielsen, M, Mackel, F, Maisano-Brown, J, Maj, O, Makowski, D, Manduchi, G, Maragkoudakis, E, Marchuk, O, Marsen, S, Martines, E, Martinez-Fernandez, J, Marushchenko, M, Masuzaki, S, Maurer, D, Mayer, M, Mccarthy, K, Mccormack, O, Mcneely, P, Meister, H, Mendelevitch, B, Mendes, S, Merlo, A, Messian, A, Mielczarek, A, Mishchenko, O, Missal, B, Mitteau, R, Moiseenko, V, Mollen, A, Moncada, V, Monnich, T, Morisaki, T, Moseev, D, Motojima, G, Mulas, S, Mulsow, M, Nagel, M, Naujoks, D, Naulin, V, Neelis, T, Neilson, H, Neu, R, Neubauer, O, Neuner, U, Nicolai, D, Nielsen, S, Niemann, H, Nishiza, T, Nishizawa, T, Nuhrenberg, C, Ochoukov, R, Oelmann, J, Offermanns, G, Ogawa, K, Okamura, S, Olmanns, J, Ongena, J, Oosterbeek, J, Otte, M, Pablant, N, Alvarez, N, Pandey, A, Pasch, E, Pavlichenko, R, Pavone, A, Pawelec, E, Pechstein, G, Pelka, G, Perseo, V, Peterson, B, Pilopp, D, Pingel, S, Pisano, F, Plockl, B, Plunk, G, Poloskei, P, Pompe, B, Popov, A, Porkolab, M, Proll, J, Pueschel, M, Puiatti, M, Sitjes, A, Purps, F, Rahbarnia, K, Rasinski, M, Rasmussen, J, Reiman, A, Reimold, F, Reisner, M, Reiter, D, Richou, M, Riedl, R, Riemann, J, Risse, K, Roberg-Clark, G, Rohde, V, Romazanov, J, Rondeshagen, D, Rong, P, Rudischhauser, L, Rummel, T, Rummel, K, Runov, A, Rust, N, Ryc, L, Salembier, P, Salewski, M, Sanchez, E, Satake, S, Satheeswaran, G, Schacht, J, Scharff, E, Schauer, F, Schilling, J, Schlisio, G, Schmid, K, Schmitt, J, Schmitz, O, Schneider, W, Schneider, M, Schneider, P, Schrittwieser, R, Schroder, T, Schroder, M, Schroeder, R, Schweer, B, Schworer, D, Scott, E, Shanahan, B, Sias, G, Sichta, P, Singer, M, Sinha, P, Siplia, S, Slaby, C, Sleczka, M, Smith, H, Smoniewski, J, Sonnendrucker, E, Spolaore, M, Spring, A, Stadler, R, Stanczak, D, Stange, T, Stepanov, I, Stephey, L, Stober, J, Stroth, U, Strumberger, E, Suzuki, C, Suzuki, Y, Svensson, J, Szabolics, T, Szepesi, T, Szucs, M, Tabares, F, Tamura, N, Tancetti, A, Tantos, C, Terry, J, Thienpondt, H, Thomsen, H, Thumm, M, Travere, J, Traverso, P, Tretter, J, Trier, E, Mora, H, Tsujimura, T, Turkin, Y, Tykhyi, A, Unterberg, B, van Eeten, P, van Milligen, B, van Schoor, M, Vano, L, Varoutis, S, Vecsei, M, Vela, L, Velasco, J, Vervier, M, Vianello, N, Viebke, H, Vilbrandt, R, Vogel, G, Vogt, N, Volkhausen, C, von Stechow, A, Wagner, F, Wang, E, Wang, H, Warmer, F, Wauters, T, Wegener, L, Wegner, T, Weir, G, Wenzel, U, White, A, Wilde, F, Wilms, F, Windisch, T, Winkler, M, Winter, A, Winters, V, Wolf, R, Wright, A, Wurden, G, Xanthopoulos, P, Xu, S, Yamada, H, Yamaguchi, H, Yokoyama, M, Yoshinuma, M, Yu, Q, Zamanov, M, Zanini, M, Zarnstorff, M, Zhang, D, Zhou, S, Zhu, J, Zhu, C, Zilker, M, Zocco, A, Zohm, H, Zoletnik, S, Zsuga, L, Pedersen T. S., Abramovic I., Agostinetti P., Torres M. A., Akaslompolo S., Belloso J. A., Aleynikov P., Aleynikova K., Alhashimi M., Ali A., Allen N., Alonso A., Anda G., Andreeva T., Angioni C., Arkhipov A., Arnold A., Asad W., Ascasibar E., Aumeunier M. -H., Avramidis K., Aymerich E., Baek S. -G., Bahner J., Baillod A., Balden M., Baldzuhn J., Ballinger S., Banduch M., Bannmann S., Navarro A. B., Barbui T., Beidler C., Belafdil C., Bencze A., Benndorf A., Beurskens M., Biedermann C., Biletskyi O., Blackwell B., Blatzheim M., Bluhm T., Bockenhoff D., Bongiovi G., Borchardt M., Borodin D., Boscary J., Bosch H., Bosmann T., Boswirth B., Bottger L., Bottino A., Bozhenkov S., Brakel R., Brandt C., Brauer T., Braune H., Brezinsek S., Brunner K., Buller S., Burhenn R., Bussiahn R., Buttenschon B., Buzas A., Bykov V., Calvo I., Mata K. C., Caminal I., Cannas B., Cappa A., Carls A., Carovani F., Carr M., Carralero D., Carvalho B., Casas J., Castano-Bardawil D., Castejon F., Chaudhary N., Chelis I., Chomiczewska A., Coenen J. W., Cole M., Cordella F., Corre Y., Crombe K., Cseh G., Csillag B., Damm H., Day C., de Baar M., De la Cal E., Degenkolbe S., Demby A., Denk S., Dhard C., Di Siena A., Dinklage A., Dittmar T., Dreval M., Drevlak M., Drewelow P., Drews P., Dunai D., Edlund E., Effenberg F., Ehrke G., Endler M., Ennis D. A., Escoto F. J., Estrada T., Fable E., Fahrenkamp N., Fanni A., Faustin J., Fellinger J., Feng Y., Figacz W., Flom E., Ford O., Fornal T., Frerichs H., Freundt S., Fuchert G., Fukuyama M., Fullenbach F., Gantenbein G., Gao Y., Garcia K., Regana J. M. G., Garcia-Cortes I., Gaspar J., Gates D. A., Geiger J., Geiger B., Giudicotti L., Gonzalez A., Goriaev A., Gradic D., Grahl M., Graves J. P., Green J., Grelier E., Greuner H., Gross S., Grote H., Groth M., Gruca M., Grulke O., Grun M., Arnaiz J. G., Gunter S., Haak V., Haas M., Hacker P., Hakola A., Hallenbert A., Hammond K., Han X., Hansen S. K., Harris J. H., Hartfuss H., Hartmann D., Hathiramani D., Hatzky R., Hawke J., Hegedus S., Hein B., Heinemann B., Helander P., Henneberg S., Hergenhahn U., Hidalgo C., Hindenlang F., Hirsch M., Hofel U., Hollfeld K. P., Holtz A., Hopf D., Hoschen D., Houry M., Howard J., Huang X., Hubeny M., Hudson S., Ida K., Igitkhanov Y., Igochine V., Illy S., Ionita-Schrittwieser C., Isobe M., Jablczynska M., Jablonski S., Jagielski B., Jakubowski M., van Vuuren A. J., Jelonnek J., Jenko F., Jensen T., Jenzsch H., Junghanns P., Kaczmarczyk J., Kallmeyer J., Kamionka U., Kandler M., Kasilov S., Kazakov Y., Kennedy D., Kharwandikar A., Khokhlov M., Kiefer C., Killer C., Kirschner A., Kleiber R., Klinger T., Klose S., Knauer J., Knieps A., Kochl F., Kocsis G., Kolesnichenko Ya. I., Konies A., Konig R., Kontula J., Kornejew P., Koschinsky J., Kozulia M. M., Kramer-Flecken A., Krampitz R., Krause M., Krawczyk N., Kremeyer T., Krier L., Kriete D. M., Krychowiak M., Ksiazek I., Kubkowska M., Kuczynski M., Kuhner G., Kumar A., Kurki-Suonio T., Kwak S., Landreman M., Lang P. T., Langenberg A., Laqua H. P., Laqua H., Laube R., Lazerson S., Lewerentz M., Li C., Liang Y., Linsmeier Ch., Lion J., Litnovsky A., Liu S., Lobsien J., Loizu J., Lore J., Lorenz A., Losada U., Louche F., Lunsford R., Lutsenko V., Machielsen M., Mackel F., Maisano-Brown J., Maj O., Makowski D., Manduchi G., Maragkoudakis E., Marchuk O., Marsen S., Martines E., Martinez-Fernandez J., Marushchenko M., Masuzaki S., Maurer D., Mayer M., McCarthy K. J., McCormack O., McNeely P., Meister H., Mendelevitch B., Mendes S., Merlo A., Messian A., Mielczarek A., Mishchenko O., Missal B., Mitteau R., Moiseenko V. E., Mollen A., Moncada V., Monnich T., Morisaki T., Moseev D., Motojima G., Mulas S., Mulsow M., Nagel M., Naujoks D., Naulin V., Neelis T., Neilson H., Neu R., Neubauer O., Neuner U., Nicolai D., Nielsen S. K., Niemann H., Nishiza T., Nishizawa T., Nuhrenberg C., Ochoukov R., Oelmann J., Offermanns G., Ogawa K., Okamura S., Olmanns J., Ongena J., Oosterbeek J., Otte M., Pablant N., Alvarez N. P., Pandey A., Pasch E., Pavlichenko R., Pavone A., Pawelec E., Pechstein G., Pelka G., Perseo V., Peterson B., Pilopp D., Pingel S., Pisano F., Plockl B., Plunk G., Poloskei P., Pompe B., Popov A., Porkolab M., Proll J., Pueschel M. J., Puiatti M. -E., Sitjes A. P., Purps F., Rahbarnia K., Rasinski M., Rasmussen J., Reiman A., Reimold F., Reisner M., Reiter D., Richou M., Riedl R., Riemann J., Risse K., Roberg-Clark G., Rohde V., Romazanov J., Rondeshagen D., Rong P., Rudischhauser L., Rummel T., Rummel K., Runov A., Rust N., Ryc L., Salembier P., Salewski M., Sanchez E., Satake S., Satheeswaran G., Schacht J., Scharff E., Schauer F., Schilling J., Schlisio G., Schmid K., Schmitt J., Schmitz O., Schneider W., Schneider M., Schneider P., Schrittwieser R., Schroder T., Schroder M., Schroeder R., Schweer B., Schworer D., Scott E., Shanahan B., Sias G., Sichta P., Singer M., Sinha P., Siplia S., Slaby C., Sleczka M., Smith H., Smoniewski J., Sonnendrucker E., Spolaore M., Spring A., Stadler R., Stanczak D., Stange T., Stepanov I., Stephey L., Stober J., Stroth U., Strumberger E., Suzuki C., Suzuki Y., Svensson J., Szabolics T., Szepesi T., Szucs M., Tabares F. L., Tamura N., Tancetti A., Tantos C., Terry J., Thienpondt H., Thomsen H., Thumm M., Travere J. M., Traverso P., Tretter J., Trier E., Mora H. T., Tsujimura T., Turkin Y., Tykhyi A., Unterberg B., van Eeten P., van Milligen B. Ph., van Schoor M., Vano L., Varoutis S., Vecsei M., Vela L., Velasco J. L., Vervier M., Vianello N., Viebke H., Vilbrandt R., Vogel G., Vogt N., Volkhausen C., von Stechow A., Wagner F., Wang E., Wang H., Warmer F., Wauters T., Wegener L., Wegner T., Weir G., Wenzel U., White A., Wilde F., Wilms F., Windisch T., Winkler M., Winter A., Winters V., Wolf R., Wright A. M., Wurden G. A., Xanthopoulos P., Xu S., Yamada H., Yamaguchi H., Yokoyama M., Yoshinuma M., Yu Q., Zamanov M., Zanini M., Zarnstorff M., Zhang D., Zhou S., Zhu J., Zhu C., Zilker M., Zocco A., Zohm H., Zoletnik S., Zsuga L., Pedersen, T, Abramovic, I, Agostinetti, P, Torres, M, Akaslompolo, S, Belloso, J, Aleynikov, P, Aleynikova, K, Alhashimi, M, Ali, A, Allen, N, Alonso, A, Anda, G, Andreeva, T, Angioni, C, Arkhipov, A, Arnold, A, Asad, W, Ascasibar, E, Aumeunier, M, Avramidis, K, Aymerich, E, Baek, S, Bahner, J, Baillod, A, Balden, M, Baldzuhn, J, Ballinger, S, Banduch, M, Bannmann, S, Navarro, A, Barbui, T, Beidler, C, Belafdil, C, Bencze, A, Benndorf, A, Beurskens, M, Biedermann, C, Biletskyi, O, Blackwell, B, Blatzheim, M, Bluhm, T, Bockenhoff, D, Bongiovi, G, Borchardt, M, Borodin, D, Boscary, J, Bosch, H, Bosmann, T, Boswirth, B, Bottger, L, Bottino, A, Bozhenkov, S, Brakel, R, Brandt, C, Brauer, T, Braune, H, Brezinsek, S, Brunner, K, Buller, S, Burhenn, R, Bussiahn, R, Buttenschon, B, Buzas, A, Bykov, V, Calvo, I, Mata, K, Caminal, I, Cannas, B, Cappa, A, Carls, A, Carovani, F, Carr, M, Carralero, D, Carvalho, B, Casas, J, Castano-Bardawil, D, Castejon, F, Chaudhary, N, Chelis, I, Chomiczewska, A, Coenen, J, Cole, M, Cordella, F, Corre, Y, Crombe, K, Cseh, G, Csillag, B, Damm, H, Day, C, de Baar, M, De la Cal, E, Degenkolbe, S, Demby, A, Denk, S, Dhard, C, Di Siena, A, Dinklage, A, Dittmar, T, Dreval, M, Drevlak, M, Drewelow, P, Drews, P, Dunai, D, Edlund, E, Effenberg, F, Ehrke, G, Endler, M, Ennis, D, Escoto, F, Estrada, T, Fable, E, Fahrenkamp, N, Fanni, A, Faustin, J, Fellinger, J, Feng, Y, Figacz, W, Flom, E, Ford, O, Fornal, T, Frerichs, H, Freundt, S, Fuchert, G, Fukuyama, M, Fullenbach, F, Gantenbein, G, Gao, Y, Garcia, K, Regana, J, Garcia-Cortes, I, Gaspar, J, Gates, D, Geiger, J, Geiger, B, Giudicotti, L, Gonzalez, A, Goriaev, A, Gradic, D, Grahl, M, Graves, J, Green, J, Grelier, E, Greuner, H, Gross, S, Grote, H, Groth, M, Gruca, M, Grulke, O, Grun, M, Arnaiz, J, Gunter, S, Haak, V, Haas, M, Hacker, P, Hakola, A, Hallenbert, A, Hammond, K, Han, X, Hansen, S, Harris, J, Hartfuss, H, Hartmann, D, Hathiramani, D, Hatzky, R, Hawke, J, Hegedus, S, Hein, B, Heinemann, B, Helander, P, Henneberg, S, Hergenhahn, U, Hidalgo, C, Hindenlang, F, Hirsch, M, Hofel, U, Hollfeld, K, Holtz, A, Hopf, D, Hoschen, D, Houry, M, Howard, J, Huang, X, Hubeny, M, Hudson, S, Ida, K, Igitkhanov, Y, Igochine, V, Illy, S, Ionita-Schrittwieser, C, Isobe, M, Jablczynska, M, Jablonski, S, Jagielski, B, Jakubowski, M, van Vuuren, A, Jelonnek, J, Jenko, F, Jensen, T, Jenzsch, H, Junghanns, P, Kaczmarczyk, J, Kallmeyer, J, Kamionka, U, Kandler, M, Kasilov, S, Kazakov, Y, Kennedy, D, Kharwandikar, A, Khokhlov, M, Kiefer, C, Killer, C, Kirschner, A, Kleiber, R, Klinger, T, Klose, S, Knauer, J, Knieps, A, Kochl, F, Kocsis, G, Kolesnichenko, Y, Konies, A, Konig, R, Kontula, J, Kornejew, P, Koschinsky, J, Kozulia, M, Kramer-Flecken, A, Krampitz, R, Krause, M, Krawczyk, N, Kremeyer, T, Krier, L, Kriete, D, Krychowiak, M, Ksiazek, I, Kubkowska, M, Kuczynski, M, Kuhner, G, Kumar, A, Kurki-Suonio, T, Kwak, S, Landreman, M, Lang, P, Langenberg, A, Laqua, H, Laube, R, Lazerson, S, Lewerentz, M, Li, C, Liang, Y, Linsmeier, C, Lion, J, Litnovsky, A, Liu, S, Lobsien, J, Loizu, J, Lore, J, Lorenz, A, Losada, U, Louche, F, Lunsford, R, Lutsenko, V, Machielsen, M, Mackel, F, Maisano-Brown, J, Maj, O, Makowski, D, Manduchi, G, Maragkoudakis, E, Marchuk, O, Marsen, S, Martines, E, Martinez-Fernandez, J, Marushchenko, M, Masuzaki, S, Maurer, D, Mayer, M, Mccarthy, K, Mccormack, O, Mcneely, P, Meister, H, Mendelevitch, B, Mendes, S, Merlo, A, Messian, A, Mielczarek, A, Mishchenko, O, Missal, B, Mitteau, R, Moiseenko, V, Mollen, A, Moncada, V, Monnich, T, Morisaki, T, Moseev, D, Motojima, G, Mulas, S, Mulsow, M, Nagel, M, Naujoks, D, Naulin, V, Neelis, T, Neilson, H, Neu, R, Neubauer, O, Neuner, U, Nicolai, D, Nielsen, S, Niemann, H, Nishiza, T, Nishizawa, T, Nuhrenberg, C, Ochoukov, R, Oelmann, J, Offermanns, G, Ogawa, K, Okamura, S, Olmanns, J, Ongena, J, Oosterbeek, J, Otte, M, Pablant, N, Alvarez, N, Pandey, A, Pasch, E, Pavlichenko, R, Pavone, A, Pawelec, E, Pechstein, G, Pelka, G, Perseo, V, Peterson, B, Pilopp, D, Pingel, S, Pisano, F, Plockl, B, Plunk, G, Poloskei, P, Pompe, B, Popov, A, Porkolab, M, Proll, J, Pueschel, M, Puiatti, M, Sitjes, A, Purps, F, Rahbarnia, K, Rasinski, M, Rasmussen, J, Reiman, A, Reimold, F, Reisner, M, Reiter, D, Richou, M, Riedl, R, Riemann, J, Risse, K, Roberg-Clark, G, Rohde, V, Romazanov, J, Rondeshagen, D, Rong, P, Rudischhauser, L, Rummel, T, Rummel, K, Runov, A, Rust, N, Ryc, L, Salembier, P, Salewski, M, Sanchez, E, Satake, S, Satheeswaran, G, Schacht, J, Scharff, E, Schauer, F, Schilling, J, Schlisio, G, Schmid, K, Schmitt, J, Schmitz, O, Schneider, W, Schneider, M, Schneider, P, Schrittwieser, R, Schroder, T, Schroder, M, Schroeder, R, Schweer, B, Schworer, D, Scott, E, Shanahan, B, Sias, G, Sichta, P, Singer, M, Sinha, P, Siplia, S, Slaby, C, Sleczka, M, Smith, H, Smoniewski, J, Sonnendrucker, E, Spolaore, M, Spring, A, Stadler, R, Stanczak, D, Stange, T, Stepanov, I, Stephey, L, Stober, J, Stroth, U, Strumberger, E, Suzuki, C, Suzuki, Y, Svensson, J, Szabolics, T, Szepesi, T, Szucs, M, Tabares, F, Tamura, N, Tancetti, A, Tantos, C, Terry, J, Thienpondt, H, Thomsen, H, Thumm, M, Travere, J, Traverso, P, Tretter, J, Trier, E, Mora, H, Tsujimura, T, Turkin, Y, Tykhyi, A, Unterberg, B, van Eeten, P, van Milligen, B, van Schoor, M, Vano, L, Varoutis, S, Vecsei, M, Vela, L, Velasco, J, Vervier, M, Vianello, N, Viebke, H, Vilbrandt, R, Vogel, G, Vogt, N, Volkhausen, C, von Stechow, A, Wagner, F, Wang, E, Wang, H, Warmer, F, Wauters, T, Wegener, L, Wegner, T, Weir, G, Wenzel, U, White, A, Wilde, F, Wilms, F, Windisch, T, Winkler, M, Winter, A, Winters, V, Wolf, R, Wright, A, Wurden, G, Xanthopoulos, P, Xu, S, Yamada, H, Yamaguchi, H, Yokoyama, M, Yoshinuma, M, Yu, Q, Zamanov, M, Zanini, M, Zarnstorff, M, Zhang, D, Zhou, S, Zhu, J, Zhu, C, Zilker, M, Zocco, A, Zohm, H, Zoletnik, S, Zsuga, L, Pedersen T. S., Abramovic I., Agostinetti P., Torres M. A., Akaslompolo S., Belloso J. A., Aleynikov P., Aleynikova K., Alhashimi M., Ali A., Allen N., Alonso A., Anda G., Andreeva T., Angioni C., Arkhipov A., Arnold A., Asad W., Ascasibar E., Aumeunier M. -H., Avramidis K., Aymerich E., Baek S. -G., Bahner J., Baillod A., Balden M., Baldzuhn J., Ballinger S., Banduch M., Bannmann S., Navarro A. B., Barbui T., Beidler C., Belafdil C., Bencze A., Benndorf A., Beurskens M., Biedermann C., Biletskyi O., Blackwell B., Blatzheim M., Bluhm T., Bockenhoff D., Bongiovi G., Borchardt M., Borodin D., Boscary J., Bosch H., Bosmann T., Boswirth B., Bottger L., Bottino A., Bozhenkov S., Brakel R., Brandt C., Brauer T., Braune H., Brezinsek S., Brunner K., Buller S., Burhenn R., Bussiahn R., Buttenschon B., Buzas A., Bykov V., Calvo I., Mata K. C., Caminal I., Cannas B., Cappa A., Carls A., Carovani F., Carr M., Carralero D., Carvalho B., Casas J., Castano-Bardawil D., Castejon F., Chaudhary N., Chelis I., Chomiczewska A., Coenen J. W., Cole M., Cordella F., Corre Y., Crombe K., Cseh G., Csillag B., Damm H., Day C., de Baar M., De la Cal E., Degenkolbe S., Demby A., Denk S., Dhard C., Di Siena A., Dinklage A., Dittmar T., Dreval M., Drevlak M., Drewelow P., Drews P., Dunai D., Edlund E., Effenberg F., Ehrke G., Endler M., Ennis D. A., Escoto F. J., Estrada T., Fable E., Fahrenkamp N., Fanni A., Faustin J., Fellinger J., Feng Y., Figacz W., Flom E., Ford O., Fornal T., Frerichs H., Freundt S., Fuchert G., Fukuyama M., Fullenbach F., Gantenbein G., Gao Y., Garcia K., Regana J. M. G., Garcia-Cortes I., Gaspar J., Gates D. A., Geiger J., Geiger B., Giudicotti L., Gonzalez A., Goriaev A., Gradic D., Grahl M., Graves J. P., Green J., Grelier E., Greuner H., Gross S., Grote H., Groth M., Gruca M., Grulke O., Grun M., Arnaiz J. G., Gunter S., Haak V., Haas M., Hacker P., Hakola A., Hallenbert A., Hammond K., Han X., Hansen S. K., Harris J. H., Hartfuss H., Hartmann D., Hathiramani D., Hatzky R., Hawke J., Hegedus S., Hein B., Heinemann B., Helander P., Henneberg S., Hergenhahn U., Hidalgo C., Hindenlang F., Hirsch M., Hofel U., Hollfeld K. P., Holtz A., Hopf D., Hoschen D., Houry M., Howard J., Huang X., Hubeny M., Hudson S., Ida K., Igitkhanov Y., Igochine V., Illy S., Ionita-Schrittwieser C., Isobe M., Jablczynska M., Jablonski S., Jagielski B., Jakubowski M., van Vuuren A. J., Jelonnek J., Jenko F., Jensen T., Jenzsch H., Junghanns P., Kaczmarczyk J., Kallmeyer J., Kamionka U., Kandler M., Kasilov S., Kazakov Y., Kennedy D., Kharwandikar A., Khokhlov M., Kiefer C., Killer C., Kirschner A., Kleiber R., Klinger T., Klose S., Knauer J., Knieps A., Kochl F., Kocsis G., Kolesnichenko Ya. I., Konies A., Konig R., Kontula J., Kornejew P., Koschinsky J., Kozulia M. M., Kramer-Flecken A., Krampitz R., Krause M., Krawczyk N., Kremeyer T., Krier L., Kriete D. M., Krychowiak M., Ksiazek I., Kubkowska M., Kuczynski M., Kuhner G., Kumar A., Kurki-Suonio T., Kwak S., Landreman M., Lang P. T., Langenberg A., Laqua H. P., Laqua H., Laube R., Lazerson S., Lewerentz M., Li C., Liang Y., Linsmeier Ch., Lion J., Litnovsky A., Liu S., Lobsien J., Loizu J., Lore J., Lorenz A., Losada U., Louche F., Lunsford R., Lutsenko V., Machielsen M., Mackel F., Maisano-Brown J., Maj O., Makowski D., Manduchi G., Maragkoudakis E., Marchuk O., Marsen S., Martines E., Martinez-Fernandez J., Marushchenko M., Masuzaki S., Maurer D., Mayer M., McCarthy K. J., McCormack O., McNeely P., Meister H., Mendelevitch B., Mendes S., Merlo A., Messian A., Mielczarek A., Mishchenko O., Missal B., Mitteau R., Moiseenko V. E., Mollen A., Moncada V., Monnich T., Morisaki T., Moseev D., Motojima G., Mulas S., Mulsow M., Nagel M., Naujoks D., Naulin V., Neelis T., Neilson H., Neu R., Neubauer O., Neuner U., Nicolai D., Nielsen S. K., Niemann H., Nishiza T., Nishizawa T., Nuhrenberg C., Ochoukov R., Oelmann J., Offermanns G., Ogawa K., Okamura S., Olmanns J., Ongena J., Oosterbeek J., Otte M., Pablant N., Alvarez N. P., Pandey A., Pasch E., Pavlichenko R., Pavone A., Pawelec E., Pechstein G., Pelka G., Perseo V., Peterson B., Pilopp D., Pingel S., Pisano F., Plockl B., Plunk G., Poloskei P., Pompe B., Popov A., Porkolab M., Proll J., Pueschel M. J., Puiatti M. -E., Sitjes A. P., Purps F., Rahbarnia K., Rasinski M., Rasmussen J., Reiman A., Reimold F., Reisner M., Reiter D., Richou M., Riedl R., Riemann J., Risse K., Roberg-Clark G., Rohde V., Romazanov J., Rondeshagen D., Rong P., Rudischhauser L., Rummel T., Rummel K., Runov A., Rust N., Ryc L., Salembier P., Salewski M., Sanchez E., Satake S., Satheeswaran G., Schacht J., Scharff E., Schauer F., Schilling J., Schlisio G., Schmid K., Schmitt J., Schmitz O., Schneider W., Schneider M., Schneider P., Schrittwieser R., Schroder T., Schroder M., Schroeder R., Schweer B., Schworer D., Scott E., Shanahan B., Sias G., Sichta P., Singer M., Sinha P., Siplia S., Slaby C., Sleczka M., Smith H., Smoniewski J., Sonnendrucker E., Spolaore M., Spring A., Stadler R., Stanczak D., Stange T., Stepanov I., Stephey L., Stober J., Stroth U., Strumberger E., Suzuki C., Suzuki Y., Svensson J., Szabolics T., Szepesi T., Szucs M., Tabares F. L., Tamura N., Tancetti A., Tantos C., Terry J., Thienpondt H., Thomsen H., Thumm M., Travere J. M., Traverso P., Tretter J., Trier E., Mora H. T., Tsujimura T., Turkin Y., Tykhyi A., Unterberg B., van Eeten P., van Milligen B. Ph., van Schoor M., Vano L., Varoutis S., Vecsei M., Vela L., Velasco J. L., Vervier M., Vianello N., Viebke H., Vilbrandt R., Vogel G., Vogt N., Volkhausen C., von Stechow A., Wagner F., Wang E., Wang H., Warmer F., Wauters T., Wegener L., Wegner T., Weir G., Wenzel U., White A., Wilde F., Wilms F., Windisch T., Winkler M., Winter A., Winters V., Wolf R., Wright A. M., Wurden G. A., Xanthopoulos P., Xu S., Yamada H., Yamaguchi H., Yokoyama M., Yoshinuma M., Yu Q., Zamanov M., Zanini M., Zarnstorff M., Zhang D., Zhou S., Zhu J., Zhu C., Zilker M., Zocco A., Zohm H., Zoletnik S., and Zsuga L.

Abstract

We present recent highlights from the most recent operation phases of Wendelstein 7-X, the most advanced stellarator in the world. Stable detachment with good particle exhaust, low impurity content, and energy confinement times exceeding 100 ms, have been maintained for tens of seconds. Pellet fueling allows for plasma phases with reduced ion-temperature-gradient turbulence, and during such phases, the overall confinement is so good (energy confinement times often exceeding 200 ms) that the attained density and temperature profiles would not have been possible in less optimized devices, since they would have had neoclassical transport losses exceeding the heating applied in W7-X. This provides proof that the reduction of neoclassical transport through magnetic field optimization is successful. W7-X plasmas generally show good impurity screening and high plasma purity, but there is evidence of longer impurity confinement times during turbulence-suppressed phases.

Published
2022

30. Thrombotischer Verschluss der extrakorporalen Zirkulation während hepatischer Chemosaturation trotz zielgerechter Antikoagulation

Author

M. Kuhner, B. Tan, M. O. Fiedler, O. Biecker, B. Klein, D. H. Chang, M. A. Weigand, and M. Dietrich

Abstract

ZusammenfassungDie perkutane hepatische Chemosaturation ist eine Behandlungsoption bei nichtresektablen primären oder sekundären Lebertumoren. Dabei wird der Bereich der Lebervenenmündung der Vena cava inferior (VCI) mittels 2 Ballons von der Zirkulation isoliert, sodass die systemische Verteilung des über die Leberarterie applizierten Chemotherapeutikums Melphalan verhindert wird. Nach Passage der Leber und venöser Drainage aus der retrohepatischen VCI durchläuft das chemosaturierte Blut 2 parallel geschaltete extrakorporale Filter. Anschließend wird das gereinigte Blut jugulär rückgeführt. Das Verfahren geht oft mit einer ausgeprägten hämodynamischen Instabilität einher, deren Ursache nicht abschließend geklärt ist. Zusätzlich stellt das Gerinnungsmanagement eine Herausforderung dar. Die Autoren berichten von einem Fall, bei dem sich trotz ausreichender „activated clotting time“ (ACT) ein Thrombus im rückführenden Schenkel der extrakorporalen Zirkulation bildete. Gezielte Problemsuche und -lösung waren parallel zur hämodynamischen Stabilisierung und interdisziplinären Zusammenarbeit notwendig, um die Intervention erfolgreich durchzuführen und der Patientin eine sichere Therapie zukommen zu lassen.

Published
2022
Full Text
View/download PDF

31. Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities

Author

Hélène Levaique, Olivier Pamlard, Cécile Apel, Jérôme Bignon, Margaux Arriola, Robin Kuhner, Khalijah Awang, Philippe M. Loiseau, Marc Litaudon, and Sébastien Pomel

Subjects
Leishmania, therapeutic target, GDP-Mannose pyrophosphorylase, natural products, alkyl-resorcinol, Organic chemistry, QD241-441
Abstract

Leishmaniasis is a vector-borne disease caused by the protozoan parasite Leishmania found in tropical and sub-tropical areas, affecting 12 million people around the world. Only few treatments are available against this disease and all of them present issues of toxicity and/or resistance. In this context, the development of new antileishmanial drugs specifically directed against a therapeutic target appears to be a promising strategy. The GDP-Mannose Pyrophosphorylase (GDP-MP) has been previously shown to be an attractive therapeutic target in Leishmania. In this study, a chemical library of 5000 compounds was screened on both L. infantum (LiGDP-MP) and human (hGDP-MP) GDP-MPs. From this screening, oncostemonol D was found to be active on both GDP-MPs at the micromolar level. Ten alkyl-resorcinol derivatives, of which oncostemonols E and J (2 and 3) were described for the first time from nature, were then evaluated on both enzymes as well as on L. infantum axenic and intramacrophage amastigotes. From this evaluation, compounds 1 and 3 inhibited both GDP-MPs at the micromolar level, and compound 9 displayed a three-times lower IC50 on LiGDP-MP, at 11 µM, than on hGDP-MP. As they displayed mild activities on the parasite, these compounds need to be further pharmacomodulated in order to improve their affinity and specificity to the target as well as their antileishmanial activity.

Published
2021
Full Text
View/download PDF

34. Data from Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus

Author

Patricia L. Blount, Brian J. Reid, Thomas L. Vaughan, Steven G. Self, Carlo C. Maley, Mary K. Kuhner, Karen Liu, Carissa A. Sanchez, Patricia C. Galipeau, Thomas G. Paulson, and Xiaohong Li

Abstract

Cancers detected at a late stage are often refractory to treatments and ultimately lethal. Early detection can significantly increase survival probability, but attempts to reduce mortality by early detection have frequently increased overdiagnosis of indolent conditions that do not progress over a lifetime. Study designs that incorporate biomarker trajectories in time and space are needed to distinguish patients who progress to an early cancer from those who follow an indolent course. Esophageal adenocarcinoma is characterized by evolution of punctuated and catastrophic somatic chromosomal alterations and high levels of overall mutations but few recurrently mutated genes aside from TP53. Endoscopic surveillance of Barrett's esophagus for early cancer detection provides an opportunity for assessment of alterations for cancer risk in patients who progress to esophageal adenocarcinoma compared with nonprogressors. We investigated 1,272 longitudinally collected esophageal biopsies in a 248 Barrett's patient case–cohort study with 20,425 person-months of follow-up, including 79 who progressed to early-stage esophageal adenocarcinoma. Cancer progression risk was assessed for total chromosomal alterations, diversity, and chromosomal region-specific alterations measured with single-nucleotide polymorphism arrays in biopsies obtained over esophageal space and time. A model using 29 chromosomal features was developed for cancer risk prediction (area under receiver operator curve, 0.94). The model prediction performance was robust in two independent esophageal adenocarcinoma sets and outperformed TP53 mutation, flow cytometric DNA content, and histopathologic diagnosis of dysplasia. This study offers a strategy to reduce overdiagnosis in Barrett's esophagus and improve early detection of esophageal adenocarcinoma and potentially other cancers characterized by punctuated and catastrophic chromosomal evolution. Cancer Prev Res; 8(9); 845–56. ©2015 AACR.

Published
2023
Full Text
View/download PDF

35. Supplementary Figure S4 from Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus

Author

Patricia L. Blount, Brian J. Reid, Thomas L. Vaughan, Steven G. Self, Carlo C. Maley, Mary K. Kuhner, Karen Liu, Carissa A. Sanchez, Patricia C. Galipeau, Thomas G. Paulson, and Xiaohong Li

Abstract

ROC for combined T1+T2 data. The model was trained by repeatedly using a randomly drawn 2/3 of the combined T1+T2 data for training, and testing on the reserved 1/3 of the data. The average AUC of 10,000 ROC from the reserved test data is AUC=0.86.

Published
2023
Full Text
View/download PDF

36. Supplementary Data from Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus

Author

Brian J. Reid, Patricia L. Blount, Thomas L. Vaughan, Steven G. Self, Carlo C. Maley, Mary K. Kuhner, Robert D. Odze, Rumen L. Kostadinov, Cassandra L. Sather, Karen Liu, Jessica Arnaudo, Carissa A. Sanchez, Thomas G. Paulson, Patricia C. Galipeau, and Xiaohong Li

Abstract

PDF file 2119K, Supplementary Table S1, Cohort characteristics. Supplementary Table S2, Mean SCA and mean percent of probes with SCA per biopsy in time windows. Supplementary Table S3, SCA with similar frequency in progressors and nonprogressors in time windows before cancer or final endoscopy. Supplementary Table S4, Regions of SCA with higher frequency in progressors than in nonprogressors in time windows before cancer or final endoscopy. Supplementary Figure S1, Schematic of endoscopic landmarks and image of epithelial isolation of Barrett's epithelium. Supplementary Figure S2. Balanced gain example. Supplementary Figure S3. Individual biopsy SCA. Supplementary Figure S4, Co-selection of SCA in individual biopsies

Published
2023
Full Text
View/download PDF

37. Supplementary Methods from Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus

Author

Patricia L. Blount, Brian J. Reid, Thomas L. Vaughan, Steven G. Self, Carlo C. Maley, Mary K. Kuhner, Karen Liu, Carissa A. Sanchez, Patricia C. Galipeau, Thomas G. Paulson, and Xiaohong Li

Abstract

Supplementary Methods from Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus

Published
2023
Full Text
View/download PDF

39. Data from Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus

Author

Brian J. Reid, Patricia L. Blount, Thomas L. Vaughan, Steven G. Self, Carlo C. Maley, Mary K. Kuhner, Robert D. Odze, Rumen L. Kostadinov, Cassandra L. Sather, Karen Liu, Jessica Arnaudo, Carissa A. Sanchez, Thomas G. Paulson, Patricia C. Galipeau, and Xiaohong Li

Abstract

All cancers are believed to arise by dynamic, stochastic somatic genomic evolution with genome instability, generation of diversity, and selection of genomic alterations that underlie multistage progression to cancer. Advanced esophageal adenocarcinomas have high levels of somatic copy number alterations. Barrett's esophagus is a risk factor for developing esophageal adenocarcinoma, and somatic chromosomal alterations (SCA) are known to occur in Barrett's esophagus. The vast majority (∼95%) of individuals with Barrett's esophagus do not progress to esophageal adenocarcinoma during their lifetimes, but a small subset develop esophageal adenocarcinoma, many of which arise rapidly even in carefully monitored patients without visible endoscopic abnormalities at the index endoscopy. Using a well-designed, longitudinal case-cohort study, we characterized SCA as assessed by single-nucleotide polymorphism arrays over space and time in 79 “progressors” with Barrett's esophagus as they approach the diagnosis of cancer and 169 “nonprogressors” with Barrett's esophagus who did not progress to esophageal adenocarcinoma over more than 20,425 person-months of follow-up. The genomes of nonprogressors typically had small localized deletions involving fragile sites and 9p loss/copy neutral LOH that generate little genetic diversity and remained relatively stable over prolonged follow-up. As progressors approach the diagnosis of cancer, their genomes developed chromosome instability with initial gains and losses, genomic diversity, and selection of SCAs followed by catastrophic genome doublings. Our results support a model of differential disease dynamics in which nonprogressor genomes largely remain stable over prolonged periods, whereas progressor genomes evolve significantly increased SCA and diversity within four years of esophageal adenocarcinoma diagnosis, suggesting a window of opportunity for early detection. Cancer Prev Res; 7(1); 114–27. ©2013 AACR.

Published
2023
Full Text
View/download PDF

42. Correlations between Motor Symptoms across Different Motor Tasks, Quantified via Random Forest Feature Classification in Parkinson’s Disease

Author

Andreas Kuhner, Tobias Schubert, Massimo Cenciarini, Isabella Katharina Wiesmeier, Volker Arnd Coenen, Wolfram Burgard, Cornelius Weiller, and Christoph Maurer

Subjects
Parkinson’s disease, motion, deep brain stimulation, random forest, sensor suit, Neurology. Diseases of the nervous system, RC346-429
Abstract

BackgroundObjective assessments of Parkinson’s disease (PD) patients’ motor state using motion capture techniques are still rarely used in clinical practice, even though they may improve clinical management. One major obstacle relates to the large dimensionality of motor abnormalities in PD. We aimed to extract global motor performance measures covering different everyday motor tasks, as a function of a clinical intervention, i.e., deep brain stimulation (DBS) of the subthalamic nucleus.MethodsWe followed a data-driven, machine-learning approach and propose performance measures that employ Random Forests with probability distributions. We applied this method to 14 PD patients with DBS switched-off or -on, and 26 healthy control subjects performing the Timed Up and Go Test (TUG), the Functional Reach Test (FRT), a hand coordination task, walking 10-m straight, and a 90° curve.ResultsFor each motor task, a Random Forest identified a specific set of metrics that optimally separated PD off DBS from healthy subjects. We noted the highest accuracy (94.6%) for standing up. This corresponded to a sensitivity of 91.5% to detect a PD patient off DBS, and a specificity of 97.2% representing the rate of correctly identified healthy subjects. We then calculated performance measures based on these sets of metrics and applied those results to characterize symptom severity in different motor tasks. Task-specific symptom severity measures correlated significantly with each other and with the Unified Parkinson’s Disease Rating Scale (UPDRS, part III, correlation of r2 = 0.79). Agreement rates between different measures ranged from 79.8 to 89.3%.ConclusionThe close correlation of PD patients’ various motor abnormalities quantified by different, task-specific severity measures suggests that these abnormalities are only facets of the underlying one-dimensional severity of motor deficits. The identification and characterization of this underlying motor deficit may help to optimize therapeutic interventions, e.g., to “automatically” adapt DBS settings in PD patients.

Published
2017
Full Text
View/download PDF

43. Show 'n' Tell Nutrition at School

Author

Kuhner, Jeanne Incantalupo

Abstract

The U.S. Congress has passed a measure that would scrap the Child Nutrition Act's requirements and funding for more healthy lunches in schools. Unfortunately, foods of lower nutritional value are more available than healthier snacks in the nation's schools. The author argues that providing students with more fresh fruit and produce, whole grains and healthy protein promotes making healthy choices and can help them develop habits for a healthy lifestyle. Education has the power to help change the trend, the author says.

Published
2012

46. Bulk Genotyping of Biopsies Can Create Spurious Evidence for Hetereogeneity in Mutation Content.

Author

Rumen Kostadinov, Carlo C Maley, and Mary K Kuhner

Subjects
Biology (General), QH301-705.5
Abstract

When multiple samples are taken from the neoplastic tissues of a single patient, it is natural to compare their mutation content. This is often done by bulk genotyping of whole biopsies, but the chance that a mutation will be detected in bulk genotyping depends on its local frequency in the sample. When the underlying mutation count per cell is equal, homogenous biopsies will have more high-frequency mutations, and thus more detectable mutations, than heterogeneous ones. Using simulations, we show that bulk genotyping of data simulated under a neutral model of somatic evolution generates strong spurious evidence for non-neutrality, because the pattern of tissue growth systematically generates differences in biopsy heterogeneity. Any experiment which compares mutation content across bulk-genotyped biopsies may therefore suggest mutation rate or selection intensity variation even when these forces are absent. We discuss computational and experimental approaches for resolving this problem.

Published
2016
Full Text
View/download PDF

48. Metasurface-Enhanced Infrared Spectroscopy: An Abundance of Materials and Functionalities

Author

John-Herpin, Aurelian, Tittl, Andreas, Kuhner, Lucca, Richter, Felix, Huang, Steven H., Shvets, Gennady, Oh, Sang-Hyun, Altug, Hatice, John-Herpin, Aurelian, Tittl, Andreas, Kuhner, Lucca, Richter, Felix, Huang, Steven H., Shvets, Gennady, Oh, Sang-Hyun, and Altug, Hatice

Abstract

Infrared spectroscopy provides unique information on the composition and dynamics of biochemical systems by resolving the characteristic absorption fingerprints of their constituent molecules. Based on this inherent chemical specificity and the capability for label-free, noninvasive, and real-time detection, infrared spectroscopy approaches have unlocked a plethora of breakthrough applications for fields ranging from environmental monitoring and defense to chemical analysis and medical diagnostics. Nanophotonics has played a crucial role for pushing the sensitivity limits of traditional far-field spectroscopy by using resonant nanostructures to focus the incident light into nanoscale hot-spots of the electromagnetic field, greatly enhancing light-matter interaction. Metasurfaces composed of regular arrangements of such resonators further increase the design space for tailoring this nanoscale light control both spectrally and spatially, which has established them as an invaluable toolkit for surface-enhanced spectroscopy. Starting from the fundamental concepts of metasurface-enhanced infrared spectroscopy, a broad palette of resonator geometries, materials, and arrangements for realizing highly sensitive metadevices is showcased, with a special focus on emerging systems such as phononic and 2D van der Waals materials, and integration with waveguides for lab-on-a-chip devices. Furthermore, advanced sensor functionalities of metasurface-based infrared spectroscopy, including multiresonance, tunability, dielectrophoresis, live cell sensing, and machine-learning-aided analysis are highlighted.

Published
2022
Full Text
View/download PDF

50. Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression

Author

Paulson, Thomas G., primary, Galipeau, Patricia C., additional, Oman, Kenji M., additional, Sanchez, Carissa A., additional, Kuhner, Mary K., additional, Smith, Lucian P., additional, Hadi, Kevin, additional, Shah, Minita, additional, Arora, Kanika, additional, Shelton, Jennifer, additional, Johnson, Molly, additional, Corvelo, Andre, additional, Maley, Carlo C., additional, Yao, Xiaotong, additional, Sanghvi, Rashesh, additional, Venturini, Elisa, additional, Emde, Anne-Katrin, additional, Hubert, Benjamin, additional, Imielinski, Marcin, additional, Robine, Nicolas, additional, Reid, Brian J., additional, and Li, Xiaohong, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results