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1. Conversations in cardiology: Late career transitions—Retool, retire, refocus

Author

Kern, Morton J, Applegate, Bob, Bittl, John, Block, Peter, Butman, Sam, Dehmer, Gregory, Garratt, Kirk N, Henry, Tim, Hirshfeld, John, Holmes, David R, Kaplan, Aaron, King, Spencer, Klein, Lloyd W, Krucoff, Mitchell W, Kutcher, Michael A, Naidu, Srihari S, Pichard, Augusto, Ruiz, Carlos E, Skelding, Kimberly A, Tobis, Jonathan M, Tommaso, Carl, Weiner, Bonnie H, and White, Christopher

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiology, Cardiovascular System, Career Choice, Career Mobility, Humans, Retirement, Treatment Outcome, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Published
2022

2. Dyspnea-Related Ticagrelor Discontinuation After Percutaneous Coronary Intervention

Author

Angiolillo, Dominick J., Cao, Davide, Sartori, Samantha, Baber, Usman, Dangas, George, Zhang, Zhongjie, Vogel, Birgit, Kunadian, Vijay, Briguori, Carlo, Cohen, David J., Collier, Timothy, Dudek, Dariusz, Gibson, Michael, Gil, Robert, Huber, Kurt, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell W., Ielasi, Alfonso, Stefanini, Giulio G., Pivato, Carlo A., Mehta, Shamir, Moliterno, David J., Ohman, E. Magnus, Escaned, Javier, Sardella, Gennaro, Sharma, Samin K., Shlofmitz, Richard, Weisz, Giora, Witzenbichler, Bernhard, Steg, P. Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2023
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3. 1- or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After PCI

Author

Valgimigli, Marco, Spirito, Alessandro, Sartori, Samantha, Angiolillo, Dominick J., Vranckx, Pascal, de la Torre Hernandez, Jose M., Krucoff, Mitchell W., Bangalore, Sripal, Bhatt, Deepak L., Campo, Gianluca, Cao, Davide, Chehab, Bassem M., Choi, James W., Feng, Yihan, Ge, Junbo, Hermiller, James, Kunadian, Vijay, Lupo, Sydney, Makkar, Raj R., Maksoud, Aziz, Neumann, Franz-Josef, Picon, Hector, Saito, Shigeru, Sardella, Gennaro, Thiele, Holger, Toelg, Ralph, Varenne, Olivier, Vogel, Birgit, Zhou, Yujie, Windecker, Stephan, and Mehran, Roxana

Published
2023
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4. Minimum Core Data Elements for Transcatheter Mitral Therapies: Scientific Statement by PASSION CV, HVC, and TVTR

Author

Vemulapalli, Sreekanth, Simonato, Matheus, Ben Yehuda, Ori, Wu, Changfu, Feldman, Ted, Popma, Jeffrey J., Sundareswaren, Kartik, Krohn, Carole, Hardy, Karen M., Guibone, Kimberly, Christensen, Barbara, Alu, Maria C., Ng, Vivian G., Chau, Katherine H., Chen, Shmuel, Shahim, Bahira, Vincent, Flavien, MacMahon, John, James, Stefan, Mack, Michael, Leon, Martin B., Thourani, Vinod H., Carroll, John, and Krucoff, Mitchell W.

Published
2023
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5. Position Statement on Vascular Access Safety for Percutaneous Devices in AMI Complicated by Cardiogenic Shock

Author

Damluji, Abdulla A., Tehrani, Behnam, Sinha, Shashank S., Samsky, Marc D., Henry, Timothy D., Thiele, Holger, West, Nick E.J., Senatore, Fortunato F., Truesdell, Alexander G., Dangas, George D., Smilowitz, Nathaniel R., Amin, Amit P., deVore, Adam D., Moazami, Nader, Cigarroa, Joaquin E., Rao, Sunil V., Krucoff, Mitchell W., Morrow, David A., and Gilchrist, Ian C.

Published
2022
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6. Bleeding and Ischemic Outcomes With Ticagrelor Monotherapy According to Body Mass Index

Author

Kunadian, Vijay, Baber, Usman, Pivato, Carlo A., Cao, Davide, Dangas, George, Sartori, Samantha, Zhang, Zhongjie, Angiolillo, Dominick J., Briguori, Carlo, Cohen, David J., Collier, Timothy, Dudek, Dariusz, Gibson, Michael, Gil, Robert, Huber, Kurt, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell W., Dehghani, Payam, Mehta, Shamir, Moliterno, David J., Ohman, E. Magnus, Escaned, Javier, Sardella, Gennaro, Sharma, Samin K., Shlofmitz, Richard, Weisz, Giora, Witzenbichler, Bernhard, Džavík, Vladimír, Gurbel, Paul, Hamm, Christian W., Henry, Timothy, Kastrati, Adnan, Marx, Steven O., Oldroyd, Keith, Steg, P. Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2022
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7. Minimum Core Data Elements for Evaluation of TAVR: A Scientific Statement by PASSION CV, HVC, and TVT Registry

Author

Simonato, Matheus, Vemulapalli, Sreekanth, Ben-Yehuda, Ori, Wu, Changfu, Wood, Larry, Popma, Jeff, Feldman, Ted, Krohn, Carole, Hardy, Karen M., Guibone, Kimberly, Christensen, Barbara, Alu, Maria C., Chen, Shmuel, Ng, Vivian G., Chau, Katherine H., Shahim, Bahira, Vincent, Flavien, MacMahon, John, James, Stefan, Mack, Michael, Leon, Martin B., Thourani, Vinod H., Carroll, John, and Krucoff, Mitchell

Published
2022
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8. Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium

Author

Capodanno, Davide, Mehran, Roxana, Krucoff, Mitchell W., Baber, Usman, Bhatt, Deepak L., Capranzano, Piera, Collet, Jean-Philippe, Cuisset, Thomas, De Luca, Giuseppe, De Luca, Leonardo, Farb, Andrew, Franchi, Francesco, Gibson, C. Michael, Hahn, Joo-Yong, Hong, Myeong-Ki, James, Stefan, Kastrati, Adnan, Kimura, Takeshi, Lemos, Pedro A., Lopes, Renato D., Magee, Adrian, Matsumura, Ryosuke, Mochizuki, Shuichi, O’Donoghue, Michelle L., Pereira, Naveen L., Rao, Sunil V., Rollini, Fabiana, Shirai, Yuko, Sibbing, Dirk, Smits, Peter C., Steg, P. Gabriel, Storey, Robert F., ten Berg, Jurrien, Valgimigli, Marco, Vranckx, Pascal, Watanabe, Hirotoshi, Windecker, Stephan, Serruys, Patrick W., Yeh, Robert W., Morice, Marie-Claude, and Angiolillo, Dominick J.

Published
2023
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9. Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial

Author

Brilakis, Emmanouil S, Edson, Robert, Bhatt, Deepak L, Goldman, Steven, Holmes, David R, Rao, Sunil V, Shunk, Kendrick, Rangan, Bavana V, Mavromatis, Kreton, Ramanathan, Kodangudi, Bavry, Anthony A, Garcia, Santiago, Latif, Faisal, Armstrong, Ehrin, Jneid, Hani, Conner, Todd A, Wagner, Todd, Karacsonyi, Judit, Uyeda, Lauren, Ventura, Beverly, Alsleben, Aaron, Lu, Ying, Shih, Mei-Chiung, Banerjee, Subhash, Investigators, DIVA Trial, Ahmed, Bina, Ratliff, D Michelle, Ricciardi, Mark, Sheldon, Mark, Icenogle, Milton, Snider, Richard, Ardati, Amer, Nallamothu, Brahmajee, Duvernoy, Claire, Menees, Daniel S, Gurm, Hitinder, Thomas, Michael P, Grossman, Paul, Owen, Kristine, Topaz, On, Kumar, Gautam, Block, Peter, Zidar, David A, Bezerra, Hiram, Goldberg, Jonathan, Ortiz, Jose, Jozic, Joseph, Osman, Mohammed, Rosenthal, Noah, Parikh, Sahil A, Lassar, Tom A, Chan, Albert, Kumar, Arun, Aggarwal, Kul, Cyrus, Tillmann, Grodin, Jerrold, Hattler, Brack, Casserly, Ivan, Messenger, John, Kim, Michael, Rogers, R Kevin, Waldo, Stephen, Tsai, Thomas, Morris, Kenneth, Krucoff, Mitchell, Rao, Sunil, Povsic, Thomas J, Jones, William S, Bavry, Anthony, Choi, Calvin, Park, Ki, Liu, Jayson, Kar, Biswajit, Paniagua, David, Breall, Jeffrey, Bolad, Islam, Mukerji, Rita, Subbarao, Roopa, Abdel-Latif, Ahmed, Booth, David C, Ziada, Khaled M, Rajan, Lawrence, Hakeem, Abdul, Uretsky, Barry F, Agrawal, Mayank, Sachdeva, Rajesh, Ahmed, Zubair, McGee, Jesse, Shah, Rahman, Sharma, Alok, McFalls, Edward, Siddiqui, Rizwan, and Adabag, Selcuk

Subjects
Biomedical and Clinical Sciences, Clinical Trials and Supportive Activities, Clinical Research, 6.3 Medical devices, 6.1 Pharmaceuticals, Cardiovascular, Aged, Double-Blind Method, Drug-Eluting Stents, Female, Graft Rejection, Humans, Male, Middle Aged, Percutaneous Coronary Intervention, Saphenous Vein, Self Expandable Metallic Stents, Thrombosis, Treatment Outcome, DIVA Trial Investigators, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundFew studies have examined the efficacy of drug-eluting stents (DES) for reducing aortocoronary saphenous vein bypass graft (SVG) failure compared with bare-metal stents (BMS) in patients undergoing stenting of de-novo SVG lesions. We assessed the risks and benefits of the use of DES versus BMS in de-novo SVG lesions.MethodsPatients were recruited to our double-blind, randomised controlled trial from 25 US Department of Veterans Affairs centres. Eligible participants were aged at least 18 years and had at least one significant de-novo SVG lesion (50-99% stenosis of a 2·25-4·5 mm diameter SVG) requiring percutaneous coronary intervention with intent to use embolic protection devices. Enrolled patients were randomly assigned, in a 1:1 ratio, by phone randomisation system to receive a DES or BMS. Randomisation was stratified by presence or absence of diabetes and number of target SVG lesions requiring percutaneous coronary intervention (one or two or more) within each participating site by use of an adaptive scheme intended to balance the two stent type groups on marginal totals for the stratification factors. Patients, referring physicians, study coordinators, and outcome assessors were masked to group allocation. The primary endpoint was the 12-month incidence of target vessel failure, defined as the composite of cardiac death, target vessel myocardial infarction, or target vessel revascularisation. The DIVA trial is registered with ClinicalTrials.gov, number NCT01121224.FindingsBetween Jan 1, 2012, and Dec 31, 2015, 599 patients were randomly assigned to the stent groups, and the data for 597 patients were used. The patients' mean age was 68·6 (SD 7·6) years, and 595 (>99%) patients were men. The two stent groups were similar for most baseline characteristics. At 12 months, the incidence of target vessel failure was 17% (51 of 292) in the DES group versus 19% (58 of 305) in the BMS group (adjusted hazard ratio 0·92, 95% CI 0·63-1·34, p=0·70). Between-group differences in the components of the primary endpoint, serious adverse events, or stent thrombosis were not significant. Enrolment was stopped before the revised target sample size of 762 patients was reached.InterpretationIn patients undergoing stenting of de-novo SVG lesions, no significant differences in outcomes between those receiving DES and BMS during 12 months of follow-up were found. The study results have important economic implications in countries with high DES prices such as the USA, because they suggest that the lower-cost BMS can be used in SVG lesions without compromising either safety or efficacy.FundingUS Department of Veterans Affairs Cooperative Studies Program.

Published
2018

10. Ticagrelor Monotherapy After PCI in High-Risk Patients With Prior MI: A Prespecified TWILIGHT Substudy

Author

Chiarito, Mauro, Baber, Usman, Cao, Davide, Sharma, Samin K., Dangas, George, Angiolillo, Dominick J., Briguori, Carlo, Cohen, David J., Dudek, Dariusz, Džavík, Vladimír, Escaned, Javier, Gil, Robert, Hamm, Christian W., Henry, Timothy, Huber, Kurt, Kastrati, Adnan, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell, Kunadian, Vijay, Mehta, Shamir R., Moliterno, David, Ohman, E. Magnus, Oldroyd, Keith, Sardella, Gennaro, Zhongjie, Zhang, Sartori, Samantha, Stefanini, Giulio, Shlofmitz, Richard, Steg, P. Gabriel, Weisz, Giora, Witzenbichler, Bernhard, Han, Ya-ling, Pocock, Stuart, Gibson, C. Michael, and Mehran, Roxana

Published
2022
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11. 3- or 1-Month DAPT in Patients at High Bleeding Risk Undergoing Everolimus-Eluting Stent Implantation

Author

Mehran, Roxana, Cao, Davide, Angiolillo, Dominick J., Bangalore, Sripal, Bhatt, Deepak L., Ge, Junbo, Hermiller, James, Makkar, Raj R., Neumann, Franz-Josef, Saito, Shigeru, Picon, Hector, Toelg, Ralph, Maksoud, Aziz, Chehab, Bassem M., De la Torre Hernandez, Jose M., Kunadian, Vijay, Sardella, Gennaro, Thiele, Holger, Varenne, Olivier, Vranckx, Pascal, Windecker, Stephan, Zhou, Yujie, Krucoff, Mitchell W., Ruster, Karine, Wang, Jin, and Valgimigli, Marco

Published
2021
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12. Impact of Age on the Safety and Efficacy of Ticagrelor Monotherapy in Patients Undergoing PCI

Author

Angiolillo, Dominick J., Cao, Davide, Baber, Usman, Sartori, Samantha, Zhang, Zhongjie, Dangas, George, Mehta, Shamir, Briguori, Carlo, Cohen, David J., Collier, Timothy, Dudek, Dariusz, Escaned, Javier, Gibson, C. Michael, Gil, Robert, Huber, Kurt, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell W., Kunadian, Vijay, Moliterno, David J., Ohman, E. Magnus, Oldroyd, Keith, Sardella, Gennaro, Sharma, Samin K., Shlofmitz, Richard, Weisz, Giora, Witzenbichler, Bernhard, Pocock, Stuart, and Mehran, Roxana

Published
2021
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13. Pharmacodynamic Effects of Pre-Hospital Administered Crushed Prasugrel in Patients With ST-Segment Elevation Myocardial Infarction

Author

Vogel, Rosanne F., Delewi, Ronak, Angiolillo, Dominick J., Wilschut, Jeroen M., Lemmert, Miguel E., Diletti, Roberto, van Vliet, Ria, van der Waarden, Nancy W.P.L., Nuis, Rutger-Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Krucoff, Mitchell W., van Mieghem, Nicolas M., Smits, Pieter C., and Vlachojannis, Georgios J.

Published
2021
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14. Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium

Author

Abraham, William T., Psotka, Mitchell A., Fiuzat, Mona, Filippatos, Gerasimos, Lindenfeld, JoAnn, Mehran, Roxana, Ambardekar, Amrut V., Carson, Peter E., Jacob, Richard, Januzzi, James L., Jr., Konstam, Marvin A., Krucoff, Mitchell W., Lewis, Eldrin F., Piccini, Jonathan P., Solomon, Scott D., Stockbridge, Norman, Teerlink, John R., Unger, Ellis F., Zeitler, Emily P., Anker, Stefan D., and O’Connor, Christopher M.

Published
2020
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16. Evaluation and Treatment of Patients With Lower Extremity Peripheral Artery Disease Consensus Definitions From Peripheral Academic Research Consortium (PARC)

Author

Patel, Manesh R, Conte, Michael S, Cutlip, Donald E, Dib, Nabil, Geraghty, Patrick, Gray, William, Hiatt, William R, Ho, Mami, Ikeda, Koji, Ikeno, Fumiaki, Jaff, Michael R, Jones, W Schuyler, Kawahara, Masayuki, Lookstein, Robert A, Mehran, Roxana, Misra, Sanjay, Norgren, Lars, Olin, Jeffrey W, Povsic, Thomas J, Rosenfield, Kenneth, Rundback, John, Shamoun, Fadi, Tcheng, James, Tsai, Thomas T, Suzuki, Yuka, Vranckx, Pascal, Wiechmann, Bret N, White, Christopher J, Yokoi, Hiroyoshi, and Krucoff, Mitchell W

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Clinical Trials and Supportive Activities, Angioplasty, Atherectomy, Blood Vessel Prosthesis, Constriction, Pathologic, Diagnostic Imaging, Endarterectomy, Humans, Lower Extremity, Patient Outcome Assessment, Peripheral Arterial Disease, Quality of Life, Severity of Illness Index, Stents, Walking, amputation, foot, intermittent claudication, leg, myocardial infarction, stroke, myocardial infarction, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

The lack of consistent definitions and nomenclature across clinical trials of novel devices, drugs, or biologics poses a significant barrier to accrual of knowledge in and across peripheral artery disease therapies and technologies. Recognizing this problem, the Peripheral Academic Research Consortium, together with the U.S. Food and Drug Administration and the Japanese Pharmaceuticals and Medical Devices Agency, has developed a series of pragmatic consensus definitions for patients being treated for peripheral artery disease affecting the lower extremities. These consensus definitions include the clinical presentation, anatomic depiction, interventional outcomes, surrogate imaging and physiological follow-up, and clinical outcomes of patients with lower-extremity peripheral artery disease. Consistent application of these definitions in clinical trials evaluating novel revascularization technologies should result in more efficient regulatory evaluation and best practice guidelines to inform clinical decisions in patients with lower extremity peripheral artery disease.

Published
2015

17. Dual-Antiplatelet Therapy Cessation and Cardiovascular Risk in Relation to Age: Analysis From the PARIS Registry

Author

Joyce, Lauren C., Baber, Usman, Claessen, Bimmer E., Sartori, Samantha, Chandrasekhar, Jaya, Cohen, David J., Henry, Timothy D., Ariti, Cono, Dangas, George, Faggioni, Michela, Aoi, Shunsuke, Gibson, C. Michael, Aquino, Melissa, Krucoff, Mitchell W., Vogel, Birgit, Moliterno, David J., Sorrentino, Sabato, Colombo, Antonio, Chieffo, Alaide, Kini, Annapoorna, Guedeney, Paul, Witzenbichler, Bernhard, Weisz, Giora, Steg, Philippe Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2019
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19. Direct Stenting versus Conventional Stenting in Patients with ST-Segment Elevation Myocardial Infarction—A COMPARE CRUSH Sub-Study

Author

Vogel, Rosanne F., primary, Delewi, Ronak, additional, Wilschut, Jeroen M., additional, Lemmert, Miguel E., additional, Diletti, Roberto, additional, van Vliet, Ria, additional, van der Waarden, Nancy W. P. L., additional, Nuis, Rutger-Jan, additional, Paradies, Valeria, additional, Alexopoulos, Dimitrios, additional, Zijlstra, Felix, additional, Montalescot, Gilles, additional, Angiolillo, Dominick J., additional, Krucoff, Mitchell W., additional, Van Mieghem, Nicolas M., additional, Smits, Pieter C., additional, and Vlachojannis, Georgios J., additional

Published
2023
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20. Standardized Definitions for Cardiogenic Shock Research and Mechanical Circulatory Support Devices: Scientific Expert Panel From the Shock Academic Research Consortium (SHARC)

Author

Waksman, Ron, primary, Pahuja, Mohit, additional, van Diepen, Sean, additional, Proudfoot, Alastair G., additional, Morrow, David, additional, Spitzer, Ernest, additional, Nichol, Graham, additional, Weisfeldt, Myron L., additional, Moscucci, Mauro, additional, Lawler, Patrick R., additional, Mebazaa, Alexandre, additional, Fan, Eddy, additional, Dickert, Neal W., additional, Samsky, Marc, additional, Kormos, Robert, additional, Piña, Ileana L., additional, Zuckerman, Bram, additional, Farb, Andrew, additional, Sapirstein, John S., additional, Simonton, Charles, additional, West, Nick E.J., additional, Damluji, Abdulla A., additional, Gilchrist, Ian C., additional, Zeymer, Uwe, additional, Thiele, Holger, additional, Cutlip, Donald E., additional, Krucoff, Mitchell, additional, and Abraham, William T., additional

Published
2023
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22. Incidence, Patterns, and Associations Between Dual-Antiplatelet Therapy Cessation and Risk for Adverse Events Among Patients With and Without Diabetes Mellitus Receiving Drug-Eluting Stents: Results From the PARIS Registry

Author

Faggioni, Michela, Baber, Usman, Sartori, Samantha, Giustino, Gennaro, Cohen, David J., Henry, Timothy D., Farhan, Serdar, Ariti, Cono, Dangas, George, Gibson, Michael, Giacoppo, Daniele, Krucoff, Mitchell W., Aquino, Melissa, Chandrasekhar, Jaya, Moliterno, David J., Colombo, Antonio, Vogel, Birgit, Chieffo, Alaide, Kini, Annapoorna S., Witzenbichler, Bernhard, Weisz, Giora, Steg, Philippe Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2017
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23. Definitions and Clinical Trial Design Principles for Coronary Artery Chronic Total Occlusion Therapies: CTO-ARC Consensus Recommendations

Author

Ybarra, Luiz F., Rinfret, Stéphane, Brilakis, Emmanouil S., Karmpaliotis, Dimitri, Azzalini, Lorenzo, Grantham, J. Aaron, Kandzari, David E., Mashayekhi, Kambis, Spratt, James C., Wijeysundera, Harindra C., Ali, Ziad A., Buller, Christopher E., Carlino, Mauro, Cohen, David J., Cutlip, Donald E., De Martini, Tony, Di Mario, Carlo, Farb, Andrew, Finn, Aloke V., Galassi, Alfredo R., Gibson, C. Michael, Hanratty, Colm, Hill, Jonathan M., Jaffer, Farouc A., Krucoff, Mitchell W., Lombardi, William L., Maehara, Akiko, Magee, P.F. Adrian, Mehran, Roxana, Moses, Jeffrey W., Nicholson, William J., Onuma, Yoshinobu, Sianos, Georgios, Sumitsuji, Satoru, Tsuchikane, Etsuo, Virmani, Renu, Walsh, Simon J., Werner, Gerald S., Yamane, Masahisa, Stone, Gregg W., Rinfret, Stéphane, and Stone, Gregg W.

Published
2021
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24. Effect of Prehospital Crushed Prasugrel Tablets in Patients With ST-Segment–Elevation Myocardial Infarction Planned for Primary Percutaneous Coronary Intervention: The Randomized COMPARE CRUSH Trial

Author

Vlachojannis, Georgios J., Wilschut, Jeroen M., Vogel, Rosanne F., Lemmert, Miguel E., Delewi, Ronak, Diletti, Roberto, van der Waarden, Nancy W.P.L., Nuis, Rutger-Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Angiolillo, Dominick J., Krucoff, Mitchell W., Van Mieghem, Nicolas M., and Smits, Pieter C.

Published
2020
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25. Bleeding Risk, Dual Antiplatelet Therapy Cessation, and Adverse Events After Percutaneous Coronary Intervention: The PARIS Registry

Author

Sorrentino, Sabato, Sartori, Samantha, Baber, Usman, Claessen, Bimmer E., Giustino, Gennaro, Chandrasekhar, Jaya, Chandiramani, Rishi, Cohen, David J., Henry, Timothy D., Guedeney, Paul, Ariti, Cono, Dangas, George, Gibson, C. Michael, Krucoff, Mitchell W., Moliterno, David J., Colombo, Antonio, Vogel, Birgit, Chieffo, Alaide, Kini, Annapoorna S., Witzenbichler, Bernhard, Weisz, Giora, Steg, Philippe Gabriel, Pocock, Stuart, Urban, Philip, and Mehran, Roxana

Published
2020
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27. Long-Term Safety and Efficacy of Durable Polymer Cobalt-Chromium Everolimus-Eluting Stents in Patients at High Bleeding Risk: A Patient-Level Stratified Analysis From Four Postapproval Studies

Author

Sorrentino, Sabato, Claessen, Bimmer E., Chandiramani, Rishi, Guedeney, Paul, Vogel, Birgit, Baber, Usman, Rau, Vinuta, Wang, Jin, Krucoff, Mitchell, Kozuma, Ken, Ge, Junbo, Seth, Ashok, Makkar, Raj, Liu, Yuqi, Bangalore, Sripal, Bhatt, Deepak L., Angiolillo, Dominick J., Saito, Shigeru, Neumann, Franz-Josef, Hermiller, James, Valgimigli, Marco, and Mehran, Roxana

Published
2020
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28. Bleeding and Ischemic Risks of Ticagrelor Monotherapy After Coronary Interventions

Author

Mendieta, Guiomar, primary, Mehta, Shamir, additional, Baber, Usman, additional, Angiolillo, Dominick J., additional, Briguori, Carlo, additional, Cohen, David, additional, Collier, Timothy, additional, Dangas, George, additional, Dudek, Dariusz, additional, Escaned, Javier, additional, Gil, Robert, additional, Vogel, Birgit, additional, Cao, Davide, additional, Spirito, Alessandro, additional, Huber, Kurt, additional, Kastrati, Adnan, additional, Kaul, Upendra, additional, Kornowski, Ran, additional, Krucoff, Mitchell W., additional, Kunadian, Vijay, additional, Moliterno, David J., additional, Ohman, E. Magnus, additional, Sardella, Gennaro, additional, Sartori, Samantha, additional, Sharma, Samin, additional, Shlofmitz, Richard, additional, Steg, P. Gabriel, additional, Han, Ya-Ling, additional, Pocock, Stuart, additional, Gibson, C. Michael, additional, and Mehran, Roxana, additional

Published
2023
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29. Consensus minimum core data elements adapted to peripheral vascular intervention in the drug-eluting era: consensus report from the Registry Assessment of Peripheral Interventional Devices (RAPID) Pathways “LEAN” working group

Author

Black, James H., primary, Buckley, Donna, additional, Velezis, Martha, additional, Eldrup-Jorgensen, Jens, additional, Serratore, Nina D., additional, Gutierrez, Jorge A., additional, Whatley, Eleni, additional, Marmor, Rebecca A., additional, Bertges, Daniel J., additional, Tcheng, James E., additional, Royce, Sara, additional, Malone, Misti, additional, Farb, Andrew, additional, Secemsky, Eric A., additional, Parikh, Sahil A., additional, Smale, Joshua, additional, Jaff, Michael R., additional, White, Roseann, additional, Wilgus, Rebecca W., additional, and Krucoff, Mitchell W., additional

Published
2023
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30. Sex-Based Differences in Cessation of Dual-Antiplatelet Therapy Following Percutaneous Coronary Intervention With Stents

Author

Yu, Jennifer, Baber, Usman, Mastoris, Ioannis, Dangas, George, Sartori, Samantha, Steg, Philippe Gabriel, Cohen, David J., Giustino, Gennaro, Chandrasekhar, Jaya, Ariti, Cono, Witzenbichler, Bernhard, Henry, Timothy D., Kini, Annapoorna S., Krucoff, Mitchell W., Gibson, C. Michael, Chieffo, Alaide, Moliterno, David J., Colombo, Antonio, Pocock, Stuart, and Mehran, Roxana

Published
2016
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32. Time-Dependent Associations Between Actionable Bleeding, Coronary Thrombotic Events, and Mortality Following Percutaneous Coronary Intervention: Results From the PARIS Registry

Author

Baber, Usman, Dangas, George, Chandrasekhar, Jaya, Sartori, Samantha, Steg, Philippe Gabriel, Cohen, David J., Giustino, Gennaro, Ariti, Cono, Witzenbichler, Bernhard, Henry, Timothy D., Kini, Annapoorna S., Krucoff, Mitchell W., Gibson, C. Michael, Chieffo, Alaide, Moliterno, David J., Weisz, Giora, Colombo, Antonio, Pocock, Stuart, and Mehran, Roxana

Published
2016
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35. Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention: A Consensus Document From the Academic Research Consortium for High Bleeding Risk

Author

Urban, Philip, Mehran, Roxana, Colleran, Roisin, Angiolillo, Dominick J., Byrne, Robert A., Capodanno, Davide, Cuisset, Thomas, Cutlip, Donald, Eerdmans, Pedro, Eikelboom, John, Farb, Andrew, Gibson, C. Michael, Gregson, John, Haude, Michael, James, Stefan K., Kim, Hyo-Soo, Kimura, Takeshi, Konishi, Akihide, Laschinger, John, Leon, Martin B., Magee, P.F. Adrian, Mitsutake, Yoshiaki, Mylotte, Darren, Pocock, Stuart, Price, Matthew J., Rao, Sunil V., Spitzer, Ernest, Stockbridge, Norman, Valgimigli, Marco, Varenne, Olivier, Windhoevel, Ute, Yeh, Robert W., Krucoff, Mitchell W., and Morice, Marie-Claude

Published
2019
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37. Influence of Baseline Anemia on Dual Antiplatelet Therapy Cessation and Risk of Adverse Events After Percutaneous Coronary Intervention: Insights From the PARIS Registry

Author

Faggioni, Michela, Baber, Usman, Sartori, Samantha, Chandrasekhar, Jaya, Cohen, David J., Henry, Timothy D., Claessen, Bimmer E., Dangas, George D., Gibson, C. Michael, Krucoff, Mitchell W., Vogel, Birgit, Moliterno, David J., Sorrentino, Sabato, Colombo, Antonio, Chieffo, Alaide, Kini, Annapoorna, Farhan, Serdar, Ariti, Cono, Witzenbichler, Bernard, Weisz, Giora, Steg, Philippe Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2019
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38. Sex-stratified differences in early antithrombotic treatment response in patients presenting with ST-segment elevation myocardial infarction

Author

Team Onderzoek, Cardiologie, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Delewi, Ronak, Vogel, Rosanne F., Wilschut, Jeroen M., Lemmert, Miguel E., Diletti, Roberto, van Vliet, Ria, van der Waarden, Nancy W.P.L., Nuis, Rutger Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Angiolillo, Dominick J., Krucoff, Mitchell W., Doevendans, Pieter A., Van Mieghem, Nicolas M., Smits, Pieter C., Vlachojannis, Georgios J., Team Onderzoek, Cardiologie, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Delewi, Ronak, Vogel, Rosanne F., Wilschut, Jeroen M., Lemmert, Miguel E., Diletti, Roberto, van Vliet, Ria, van der Waarden, Nancy W.P.L., Nuis, Rutger Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Angiolillo, Dominick J., Krucoff, Mitchell W., Doevendans, Pieter A., Van Mieghem, Nicolas M., Smits, Pieter C., and Vlachojannis, Georgios J.

Published
2023

39. Direct Stenting versus Conventional Stenting in Patients with ST-Segment Elevation Myocardial Infarction—A COMPARE CRUSH Sub-Study

Author

Vogel, Rosanne F., Delewi, Ronak, Wilschut, Jeroen M., Lemmert, Miguel E., Diletti, Roberto, van Vliet, Ria, van der Waarden, Nancy W.P.L., Nuis, Rutger Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Angiolillo, Dominick J., Krucoff, Mitchell W., Van Mieghem, Nicolas M., Smits, Pieter C., Vlachojannis, Georgios J., Vogel, Rosanne F., Delewi, Ronak, Wilschut, Jeroen M., Lemmert, Miguel E., Diletti, Roberto, van Vliet, Ria, van der Waarden, Nancy W.P.L., Nuis, Rutger Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Angiolillo, Dominick J., Krucoff, Mitchell W., Van Mieghem, Nicolas M., Smits, Pieter C., and Vlachojannis, Georgios J.

Abstract

Background: Direct stenting (DS) compared with conventional stenting (CS) after balloon predilatation may reduce distal embolization during percutaneous coronary intervention (PCI), thereby improving tissue reperfusion. In contrast, DS may increase the risk of stent underexpansion and target lesion failure. Methods:In this sub-study of the randomized COMPARE CRUSH trial (NCT03296540), we reviewed the efficacy of DS versus CS in a cohort of contemporary, pretreated ST-segment elevation myocardial infarction (STEMI) patients undergoing primary PCI. We compared DS versus CS, assessing (1) stent diameter in the culprit lesion, (2) thrombolysis in myocardial infarction (TIMI) flow in the infarct-related artery post-PCI and complete ST-segment resolution (STR) one-hour post-PCI, and (3) target lesion failure at one year. For proportional variables, propensity score weighting was applied to account for potential treatment selection bias. Results: This prespecified sub-study included 446 patients, of whom 189 (42%) were treated with DS. Stent diameters were comparable between groups (3.2 ± 0.5 vs. 3.2 ± 0.5 mm, p = 0.17). Post-PCI TIMI 3 flow and complete STR post-PCI rates were similar between groups (DS 93% vs. CS 90%, adjusted OR 1.16 [95% CI, 0.56–2.39], p = 0.69, and DS 72% vs. CS 58%, adjusted OR 1.29 [95% CI 0.77–2.16], p = 0.34, respectively). Moreover, target lesion failure rates at one year were comparable (DS 2% vs. 1%, adjusted OR 2.93 [95% CI 0.52–16.49], p = 0.22). Conclusion:In this contemporary pretreated STEMI cohort, we found no difference in early myocardial reperfusion outcomes between DS and CS. Moreover, DS seemed comparable to CS in terms of stent diameter and one-year vessel patency.

Published
2023

40. Sex-stratified differences in early antithrombotic treatment response in patients presenting with ST-segment elevation myocardial infarction

Author

Delewi, Ronak, Vogel, Rosanne F., Wilschut, Jeroen M., Lemmert, Miguel E., Diletti, Roberto, van Vliet, Ria, van der Waarden, Nancy W.P.L., Nuis, Rutger Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Angiolillo, Dominick J., Krucoff, Mitchell W., Doevendans, Pieter A., Van Mieghem, Nicolas M., Smits, Pieter C., Vlachojannis, Georgios J., Delewi, Ronak, Vogel, Rosanne F., Wilschut, Jeroen M., Lemmert, Miguel E., Diletti, Roberto, van Vliet, Ria, van der Waarden, Nancy W.P.L., Nuis, Rutger Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Angiolillo, Dominick J., Krucoff, Mitchell W., Doevendans, Pieter A., Van Mieghem, Nicolas M., Smits, Pieter C., and Vlachojannis, Georgios J.

Abstract

Background: The mechanisms underlying the increased risk of bleeding that female patients with ST-segment Elevation Myocardial Infarction (STEMI) exhibit, remains unclear. The present report assessed sex-related differences in response to pre-hospital dual antiplatelet therapy (DAPT) initiation in patients with STEMI. Methods: The COMPARE CRUSH trial randomized patients presenting with STEMI to receive a pre-hospital loading dose of crushed or integral prasugrel tablets in the ambulance. In this substudy, we compared platelet reactivity levels and the occurrence of high platelet reactivity (HPR; defined as platelet reactivity ≥208) between sexes at 4 prespecified time points after DAPT initiation, and evaluated post-PCI bleeding between groups. Results: Out of 633 STEMI patients, 147 (23%) were female. Females compared with males presented with significantly higher levels of platelet reactivity and higher HPR rates at baseline (232 [IQR, 209-256] vs 195 [IQR, 171-220], P < .01, and 76% vs 41%, OR 4.58 [95%CI, 2.52-8.32], P < .01, respectively). Moreover, female sex was identified as the sole independent predictor of HPR at baseline (OR 5.67 [95%CI, 2.56-12.53], P < .01). Following DAPT initiation, levels of platelet reactivity and the incidence of HPR were similar between sexes. Post-PCI bleeding occurred more frequently in females compared with males (10% vs 2%, OR 6.02 [95%CI, 2.61-11.87], P < .01). Female sex was an independent predictor of post-PCI bleeding (OR 3.25 [95%CI, 1.09-9.72], P = .04). Conclusions: In this contemporary STEMI cohort, female STEMI patients remain at risk of bleeding complications after primary PCI. However, this is not explained by sex-specific differences in the pharmacodynamic response to pre-hospital DAPT initiation.

Published
2023

41. E-11 | Contrast Fractional Flow Reserve to Evaluate the Severity of Angiographically Intermediate Coronary Lesions: Results from the Adenosine Contrast Correlations in Evaluating Revascularization (ACCELERATION) Study

Author

Swaminathan, Rajesh V., primary, Marquis-Gravel, Guillaume, additional, Rikhi, Aruna, additional, Benjamin, Daniel K., additional, Raveendran, Ganesh, additional, Chambers, Jeff W., additional, Seto, Arnold H., additional, Bagai, Jay, additional, White, Roseann, additional, Gutierrez, J. Antonio, additional, Povsic, Thomas Joseph, additional, Rao, Sunil V., additional, and Krucoff, Mitchell W., additional

Published
2023
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42. Safety and efficacy of ticagrelor monotherapy according to drug-eluting stent type: the TWILIGHT-STENT study

Author

Dangas, George, Baber, Usman, Sharma, Samin, Giustino, Gennaro, Sartori, Samantha, Nicolas, Johny, Goel, Ridhima, Mehta, Shamir, Cohen, David J., Angiolillo, Dominick J., Zhang, Zhongjie, Camaj, Anton, Cao, Davide, Briguori, Carlo, Dudek, Dariusz, Escaned, Javier, Huber, Kurt, Collier, Timothy, Kornowski, Ran, Kunadian, Vijay, Moliterno, David J., Ohman, E. Magnus, Weisz, Giora, Gil, Robert, Krucoff, Mitchell W., Kaul, Upendra, Oldroyd, Keith G., Sardella, Gennaro, Shlofmitz, Richard, Witzenbichler, Bernhard, Kastrati, Adnan, Han, Ya-ling, Steg, Philippe Gabriel, Pocock, Stuart, Gibson, C. Michael, and Mehran, Roxana

Subjects
Ticagrelor, Percutaneous Coronary Intervention, Treatment Outcome, Clinical Research, Humans, Drug-Eluting Stents, Stents, Everolimus, Cardiology and Cardiovascular Medicine, Platelet Aggregation Inhibitors
Abstract

BACKGROUND: In the TWILIGHT trial, ticagrelor monotherapy after a short course of dual antiplatelet therapy (DAPT) was shown to be a safe bleeding avoidance strategy in high-risk patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). AIMS: The aim of this study was to evaluate the effects of ticagrelor monotherapy after three-month DAPT in patients undergoing PCI, according to DES type. METHODS: In the current sub-analysis from TWILIGHT, patients were stratified into three groups based on DES type: durable polymer everolimus-eluting stents (DP-EES), durable polymer zotarolimus-eluting stents (DP-ZES), and biodegradable polymer DES (BP-DES). Bleeding and ischaemic outcomes were assessed at one year after randomisation. RESULTS: Out of 5,769 patients, 3,014 (52.2%) had DP-EES, 1,350 (23.4%) had DP-ZES and 1,405 (24.4%) had BP-DES. Compared with ticagrelor plus aspirin, ticagrelor monotherapy had significantly lower BARC type 2, 3 or 5 bleeding compared with DAPT; DP-EES (3.8% vs 6.7%; HR 0.56, 95% CI: 0.41-0.78), DP-ZES (4.6% vs 6.9%; HR 0.66, 95% CI: 0.42-1.04) and BP-DES (4.2% vs 7.9%; HR 0.52, 95% CI: 0.33-0.81; p(interaction)=0.76). Ticagrelor monotherapy resulted in similar rates of death, MI, or stroke: DP-EES (4.2% vs 4.3%; HR 0.97; 95% CI: 0.68-1.37); DP-ZES (4.1% vs 3.1%; HR 1.32; 95% CI: 0.75-2.33); BP-DES (3.9% vs 4.2%; HR 0.92; 95% CI: 0.54-1.55; p(interaction)=0.60). In both unadjusted and covariate-adjusted analyses, DES type was not associated with any differences in ischaemic or bleeding complications. CONCLUSIONS: As compared with ticagrelor plus aspirin, ticagrelor monotherapy after a short DAPT duration lowered bleeding complications without increasing the ischaemic risk, irrespective of DES type. We observed no significant differences among DES types.

Published
2022
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43. Ticagrelor with and without aspirin in patients with a prior coronary artery bypass graft undergoing percutaneous coronary intervention: the TWILIGHT-CABG study

Author

Sardella, Gennaro, primary, Beerkens, Frans J., additional, Dangas, George, additional, Cao, Davide, additional, Baber, Usman, additional, Sartori, Samantha, additional, Cohen, David J., additional, Briguori, Carlo, additional, Gil, Robert, additional, Nicolas, Johny, additional, Zhang, Zhongjie, additional, Dudek, Dariusz, additional, Kunadian, Vijay, additional, Kornowski, Ran, additional, Weisz, Giora, additional, Claessen, Bimmer, additional, Marx, Steven, additional, Escaned, Javier, additional, Huber, Kurt, additional, Collier, Timothy, additional, Moliterno, David J., additional, Ohman, E. Magnus, additional, Krucoff, Mitchell W., additional, Kastrati, Adnan, additional, Steg, Phillipe Gabriel, additional, Angiolillo, Dominick J., additional, Mehta, Shamir, additional, Shlofmitz, Richard, additional, Sharma, Samin, additional, Pocock, Stuart, additional, Gibson, Charles Michael, additional, and Mehran, Roxana, additional

Published
2022
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45. A Path Forward for Regenerative Medicine: Navigating Regulatory Challenges: Summary of Findings From the Cardiac Safety Research Consortium/Texas Heart Institute International Symposium on Cardiovascular Regenerative Medicine

Author

Fanaroff, Alexander C., Morrow, Valarie, Krucoff, Mitchell W., Seltzer, Jonathan H., Perin, Emerson C., Taylor, Doris A., Miller, Leslie W., Zeiher, Andreas M., Fernández-Avilés, Francisco, Losordo, Douglas W., Henry, Timothy D., and Povsic, Thomas J.

Published
2018
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46. Standardized End Point Definitions for Coronary Intervention Trials: The Academic Research Consortium-2 Consensus Document

Author

Garcia-Garcia, Hector M., McFadden, Eugène P., Farb, Andrew, Mehran, Roxana, Stone, Gregg W., Spertus, John, Onuma, Yoshinobu, Morel, Marie-angèle, van Es, Gerrit-Anne, Zuckerman, Bram, Fearon, William F., Taggart, David, Kappetein, Arie-Pieter, Krucoff, Mitchell W., Vranckx, Pascal, Windecker, Stephan, Cutlip, Donald, and Serruys, Patrick W.

Published
2018
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47. Incidence, Patterns, and Impact of Dual Antiplatelet Therapy Cessation Among Patients With and Without Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention: Results From the PARIS Registry (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients)

Author

Baber, Usman, Li, Shawn X., Pinnelas, Rebecca, Pocock, Stuart J., Krucoff, Mitchell W., Ariti, Cono, Gibson, C. Michael, Steg, Philippe Gabriel, Weisz, Giora, Witzenbichler, Bernhard, Henry, Timothy D., Kini, Annapoorna S., Stuckey, Thomas, Cohen, David J., Iakovou, Ioannis, Dangas, George, Aquino, Melissa B., Sartori, Samantha, Chieffo, Alaide, Moliterno, David J., Colombo, Antonio, and Mehran, Roxana

Published
2018
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49. TCT-291 Correlation Between Reduced Infarct-Related Artery Patency on Initial Angiography and Post-PCI Reperfusion TIMI Flow in STEMI Patients—A COMPARE CRUSH Subanalysis

Author

Vogel, Rosanne, primary, Delewi, Ronak, additional, Wilschut, Jeroen, additional, Lemmert, Miguel, additional, Diletti, Roberto, additional, Nuis, Rutger, additional, Paradies, Valeria, additional, Alexopoulos, Dimitrios, additional, Zijlstra, Felix, additional, Montalescot, Gilles, additional, Angiolillo, Dominick, additional, Krucoff, Mitchell, additional, Van Mieghem, Nicolas, additional, Vlachojannis, Georgios, additional, and Smits, Pieter, additional

Published
2022
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50. TCT-46 Pre-Hospital Crushed Versus Integral Prasugrel Loading Dose in Patients Presenting With Anterior ST-Segment Elevation Myocardial Infarction—A COMPARE CRUSH Subanalysis

Author

Vogel, Rosanne, primary, Wilschut, Jeroen, additional, Delewi, Ronak, additional, Lemmert, Miguel, additional, Diletti, Roberto, additional, Nuis, Rutger, additional, Paradies, Valeria, additional, Alexopoulos, Dimitrios, additional, Zijlstra, Felix, additional, Montalescot, Gilles, additional, Angiolillo, Dominick, additional, Krucoff, Mitchell, additional, van Mieghem, Nicolas, additional, Smits, Pieter, additional, and Vlachojannis, Georgios, additional

Published
2022
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