86 results on '"Kovacevic V."'
Search Results
2. Impact of renal impairment on atrial fibrillation
- Author
-
Ding W. Y., Potpara T. S., Blomstrom-Lundqvist C., Boriani G., Marin F., Fauchier L., Lip G. Y. H., Tavazzi L., Maggioni A. P., Dan G. -A., Potpara T., Nabauer M., Kalarus Z., Goda A., Mairesse G., Shalganov T., Antoniades L., Taborsky M., Riahi S., Muda P., Garcia Bolao I., Piot O., Etsadashvili K., Simantirakis E., Haim M., Azhari A., Najafian J., Santini M., Mirrakhimov E., Kulzida K., Erglis A., Poposka L., Burg M., Crijns H., Erkuner O., Atar D., Lenarczyk R., Martins Oliveira M., Shah D., Serdechnaya E., Diker E., Lane D., Zera E., Ekmekciu U., Paparisto V., Tase M., Gjergo H., Dragoti J., Ciutea M., Ahadi N., Husseini Z. E., Raepers M., Leroy J., Haushan P., Jourdan A., Lepiece C., Desteghe L., Vijgen J., Koopman P., Van Genechten G., Heidbuchel H., Boussy T., De Coninck M., Van Eeckhoutte H., Bouckaert N., Friart A., Boreux J., Arend C., Evrard P., Stefan L., Hoffer E., Herzet J., Massoz M., Celentano C., Sprynger M., Pierard L., Melon P., Van Hauwaert B., Kuppens C., Faes D., Van Lier D., Van Dorpe A., Gerardy A., Deceuninck O., Xhaet O., Dormal F., Ballant E., Blommaert D., Yakova D., Hristov M., Yncheva T., Stancheva N., Tisheva S., Tokmakova M., Nikolov F., Gencheva D., Kunev B., Stoyanov M., Marchov D., Gelev V., Traykov V., Kisheva A., Tsvyatkov H., Shtereva R., Bakalska-Georgieva S., Slavcheva S., Yotov Y., Kubickova M., Marni Joensen A., Gammelmark A., Hvilsted Rasmussen L., Dinesen P., Krogh Veno S., Sorensen B., Korsgaard A., Andersen K., Fragtrup Hellum C., Svenningsen A., Nyvad O., Wiggers P., May O., Aarup A., Graversen B., Jensen L., Andersen M., Svejgaard M., Vester S., Hansen S., Lynggaard V., Ciudad M., Vettus R., Maestre A., Castano S., Cheggour S., Poulard J., Mouquet V., Leparree S., Bouet J., Taieb J., Doucy A., Duquenne H., Furber A., Dupuis J., Rautureau J., Font M., Damiano P., Lacrimini M., Abalea J., Boismal S., Menez T., Mansourati J., Range G., Gorka H., Laure C., Vassaliere C., Elbaz N., Lellouche N., Djouadi K., Roubille F., Dietz D., Davy J., Granier M., Winum P., Leperchois-Jacquey C., Kassim H., Marijon E., Le Heuzey J., Fedida J., Maupain C., Himbert C., Gandjbakhch E., Hidden-Lucet F., Duthoit G., Badenco N., Chastre T., Waintraub X., Oudihat M., Lacoste J., Stephan C., Bader H., Delarche N., Giry L., Arnaud D., Lopez C., Boury F., Brunello I., Lefevre M., Mingam R., Haissaguerre M., Le Bidan M., Pavin D., Le Moal V., Leclercq C., Beitar T., Martel I., Schmid A., Sadki N., Romeyer-Bouchard C., Da Costa A., Arnault I., Boyer M., Piat C., Lozance N., Nastevska S., Doneva A., Fortomaroska Milevska B., Sheshoski B., Petroska K., Taneska N., Bakrecheski N., Lazarovska K., Jovevska S., Ristovski V., Antovski A., Lazarova E., Kotlar I., Taleski J., Kedev S., Zlatanovik N., Jordanova S., Bajraktarova Proseva T., Doncovska S., Maisuradze D., Esakia A., Sagirashvili E., Lartsuliani K., Natelashvili N., Gumberidze N., Gvenetadze R., Gotonelia N., Kuridze N., Papiashvili G., Menabde I., Gloggler S., Napp A., Lebherz C., Romero H., Schmitz K., Berger M., Zink M., Koster S., Sachse J., Vonderhagen E., Soiron G., Mischke K., Reith R., Schneider M., Rieker W., Boscher D., Taschareck A., Beer A., Oster D., Ritter O., Adamczewski J., Walter S., Frommhold A., Luckner E., Richter J., Schellner M., Landgraf S., Bartholome S., Naumann R., Schoeler J., Westermeier D., William F., Wilhelm K., Maerkl M., Oekinghaus R., Denart M., Kriete M., Tebbe U., Scheibner T., Gruber M., Gerlach A., Beckendorf C., Anneken L., Arnold M., Lengerer S., Bal Z., Uecker C., Fortsch H., Fechner S., Mages V., Martens E., Methe H., Schmidt T., Schaeffer B., Hoffmann B., Moser J., Heitmann K., Willems S., Klaus C., Lange I., Durak M., Esen E., Mibach F., Mibach H., Utech A., Gabelmann M., Stumm R., Landle V., Gartner C., Goerg C., Kaul N., Messer S., Burkhardt D., Sander C., Orthen R., Kaes S., Baumer A., Dodos F., Barth A., Schaeffer G., Gaertner J., Winkler J., Fahrig A., Aring J., Wenzel I., Steiner S., Kliesch A., Kratz E., Winter K., Schneider P., Haag A., Mutscher I., Bosch R., Taggeselle J., Meixner S., Schnabel A., Shamalla A., Hotz H., Korinth A., Rheinert C., Mehltretter G., Schon B., Schon N., Starflinger A., Englmann E., Baytok G., Laschinger T., Ritscher G., Gerth A., Dechering D., Eckardt L., Kuhlmann M., Proskynitopoulos N., Brunn J., Foth K., Axthelm C., Hohensee H., Eberhard K., Turbanisch S., Hassler N., Koestler A., Stenzel G., Kschiwan D., Schwefer M., Neiner S., Hettwer S., Haeussler-Schuchardt M., Degenhardt R., Sennhenn S., Brendel M., Stoehr A., Widjaja W., Loehndorf S., Logemann A., Hoskamp J., Grundt J., Block M., Ulrych R., Reithmeier A., Panagopoulos V., Martignani C., Bernucci D., Fantecchi E., Diemberger I., Ziacchi M., Biffi M., Cimaglia P., Frisoni J., Giannini I., Boni S., Fumagalli S., Pupo S., Di Chiara A., Mirone P., Pesce F., Zoccali C., Malavasi V. L., Mussagaliyeva A., Ahyt B., Salihova Z., Koshum-Bayeva K., Kerimkulova A., Bairamukova A., Lurina B., Zuzans R., Jegere S., Mintale I., Kupics K., Jubele K., Kalejs O., Vanhear K., Cachia M., Abela E., Warwicker S., Tabone T., Xuereb R., Asanovic D., Drakalovic D., Vukmirovic M., Pavlovic N., Music L., Bulatovic N., Boskovic A., Uiterwaal H., Bijsterveld N., De Groot J., Neefs J., van den Berg N., Piersma F., Wilde A., Hagens V., Van Es J., van Opstal J., Van Rennes B., Verheij H., Breukers W., Tjeerdsma G., Nijmeijer R., Wegink D., Binnema R., Said S., Philippens S., van Doorn W., Szili-Torok T., Bhagwandien R., Janse P., Muskens A., van Eck M., Gevers R., van der Ven N., Duygun A., Rahel B., Meeder J., Vold A., Holst Hansen C., Engset I., Dyduch-Fejklowicz B., Koba E., Cichocka M., Sokal A., Kubicius A., Pruchniewicz E., Kowalik-Sztylc A., Czapla W., Mroz I., Kozlowski M., Pawlowski T., Tendera M., Winiarska-Filipek A., Fidyk A., Slowikowski A., Haberka M., Lachor-Broda M., Biedron M., Gasior Z., Kolodziej M., Janion M., Gorczyca-Michta I., Wozakowska-Kaplon B., Stasiak M., Jakubowski P., Ciurus T., Drozdz J., Simiera M., Zajac P., Wcislo T., Zycinski P., Kasprzak J., Olejnik A., Harc-Dyl E., Miarka J., Pasieka M., Zieminska-Luc M., Bujak W., Sliwinski A., Grech A., Morka J., Petrykowska K., Prasal M., Hordynski G., Feusette P., Lipski P., Wester A., Streb W., Romanek J., Wozniak P., Chlebus M., Szafarz P., Stanik W., Zakrzewski M., Kazmierczak J., Przybylska A., Skorek E., Blaszczyk H., Stepien M., Szabowski S., Krysiak W., Szymanska M., Karasinski J., Blicharz J., Skura M., Halas K., Michalczyk L., Orski Z., Krzyzanowski K., Skrobowski A., Zielinski L., Tomaszewska-Kiecana M., Dluzniewski M., Kiliszek M., Peller M., Budnik M., Balsam P., Opolski G., Tyminska A., Ozieranski K., Wancerz A., Borowiec A., Majos E., Dabrowski R., Szwed H., Musialik-Lydka A., Leopold-Jadczyk A., Jedrzejczyk-Patej E., Koziel M., Mazurek M., Krzemien-Wolska K., Starosta P., Nowalany-Kozielska E., Orzechowska A., Szpot M., Staszel M., Almeida S., Pereira H., Brandao Alves L., Miranda R., Ribeiro L., Costa F., Morgado F., Carmo P., Galvao Santos P., Bernardo R., Adragao P., Ferreira da Silva G., Peres M., Alves M., Leal M., Cordeiro A., Magalhaes P., Fontes P., Leao S., Delgado A., Costa A., Marmelo B., Rodrigues B., Moreira D., Santos J., Santos L., Terchet A., Darabantiu D., Mercea S., Turcin Halka V., Pop Moldovan A., Gabor A., Doka B., Catanescu G., Rus H., Oboroceanu L., Bobescu E., Popescu R., Dan A., Buzea A., Daha I., Dan G., Neuhoff I., Baluta M., Ploesteanu R., Dumitrache N., Vintila M., Daraban A., Japie C., Badila E., Tewelde H., Hostiuc M., Frunza S., Tintea E., Bartos D., Ciobanu A., Popescu I., Toma N., Gherghinescu C., Cretu D., Patrascu N., Stoicescu C., Udroiu C., Bicescu G., Vintila V., Vinereanu D., Cinteza M., Rimbas R., Grecu M., Cozma A., Boros F., Ille M., Tica O., Tor R., Corina A., Jeewooth A., Maria B., Georgiana C., Natalia C., Alin D., Dinu-Andrei D., Livia M., Daniela R., Larisa R., Umaar S., Tamara T., Ioachim Popescu M., Nistor D., Sus I., Coborosanu O., Alina-Ramona N., Dan R., Petrescu L., Ionescu G., Vacarescu C., Goanta E., Mangea M., Ionac A., Mornos C., Cozma D., Pescariu S., Solodovnicova E., Soldatova I., Shutova J., Tjuleneva L., Zubova T., Uskov V., Obukhov D., Rusanova G., Isakova N., Odinsova S., Arhipova T., Kazakevich E., Zavyalova O., Novikova T., Riabaia I., Zhigalov S., Drozdova E., Luchkina I., Monogarova Y., Hegya D., Rodionova L., Nevzorova V., Lusanova O., Arandjelovic A., Toncev D., Vukmirovic L., Radisavljevic M., Milanov M., Sekularac N., Zdravkovic M., Hinic S., Dimkovic S., Acimovic T., Saric J., Radovanovic S., Kocijancic A., Obrenovic-Kircanski B., Kalimanovska Ostric D., Simic D., Jovanovic I., Petrovic I., Polovina M., Vukicevic M., Tomasevic M., Mujovic N., Radivojevic N., Petrovic O., Aleksandric S., Kovacevic V., Mijatovic Z., Ivanovic B., Tesic M., Ristic A., Vujisic-Tesic B., Nedeljkovic M., Karadzic A., Uscumlic A., Prodanovic M., Zlatar M., Asanin M., Bisenic B., Vasic V., Popovic Z., Djikic D., Sipic M., Peric V., Dejanovic B., Milosevic N., Backovic S., Stevanovic A., Andric A., Pencic B., Pavlovic-Kleut M., Celic V., Pavlovic M., Petrovic M., Vuleta M., Petrovic N., Simovic S., Savovic Z., Milanov S., Davidovic G., Iric-Cupic V., Djordjevic D., Damjanovic M., Zdravkovic S., Topic V., Stanojevic D., Randjelovic M., Jankovic-Tomasevic R., Atanaskovic V., Antic S., Simonovic D., Stojanovic M., Stojanovic S., Mitic V., Ilic V., Petrovic D., Deljanin Ilic M., Ilic S., Stoickov V., Markovic S., Mijatovic A., Tanasic D., Radakovic G., Peranovic J., Panic-Jelic N., Vujadinovic O., Pajic P., Bekic S., Kovacevic S., Garcia Fernandez A., Perez Cabeza A., Anguita M., Tercedor Sanchez L., Mau E., Loayssa J., Ayarra M., Carpintero M., Roldan Rabadan I., Gil Ortega M., Tello Montoliu A., Orenes Pinero E., Manzano Fernandez S., Romero Aniorte A., Veliz Martinez A., Quintana Giner M., Ballesteros G., Palacio M., Alcalde O., Garcia-Bolao I., Bertomeu Gonzalez V., Otero-Ravina F., Garcia Seara J., Gonzalez Juanatey J., Dayal N., Maziarski P., Gentil-Baron P., Koc M., Onrat E., Dural I. E., Yilmaz K., Ozin B., Tan Kurklu S., Atmaca Y., Canpolat U., Tokgozoglu L., Dolu A. K., Demirtas B., Sahin D., Ozcan Celebi O., Gagirci G., Turk U. O., Ari H., Polat N., Toprak N., Sucu M., Akin Serdar O., Taha Alper A., Kepez A., Yuksel Y., Uzunselvi A., Yuksel S., Sahin M., Kayapinar O., Ozcan T., Kaya H., Yilmaz M. B., Kutlu M., Demir M., Gibbs C., Kaminskiene S., Bryce M., Skinner A., Belcher G., Hunt J., Stancombe L., Holbrook B., Peters C., Tettersell S., Shantsila A., Senoo K., Proietti M., Russell K., Domingos P., Hussain S., Partridge J., Haynes R., Bahadur S., Brown R., McMahon S., McDonald J., Balachandran K., Singh R., Garg S., Desai H., Davies K., Goddard W., Galasko G., Rahman I., Chua Y., Payne O., Preston S., Brennan O., Pedley L., Whiteside C., Dickinson C., Brown J., Jones K., Benham L., Brady R., Buchanan L., Ashton A., Crowther H., Fairlamb H., Thornthwaite S., Relph C., McSkeane A., Poultney U., Kelsall N., Rice P., Wilson T., Wrigley M., Kaba R., Patel T., Young E., Law J., Runnett C., Thomas H., McKie H., Fuller J., Pick S., Sharp A., Hunt A., Thorpe K., Hardman C., Cusack E., Adams L., Hough M., Keenan S., Bowring A., Watts J., Zaman J., Goffin K., Nutt H., Beerachee Y., Featherstone J., Mills C., Pearson J., Stephenson L., Grant S., Wilson A., Hawksworth C., Alam I., Robinson M., Ryan S., Egdell R., Gibson E., Holland M., Leonard D., Mishra B., Ahmad S., Randall H., Hill J., Reid L., George M., McKinley S., Brockway L., Milligan W., Sobolewska J., Muir J., Tuckis L., Winstanley L., Jacob P., Kaye S., Morby L., Jan A., Sewell T., Boos C., Wadams B., Cope C., Jefferey P., Andrews N., Getty A., Suttling A., Turner C., Hudson K., Austin R., Howe S., Iqbal R., Gandhi N., Brophy K., Mirza P., Willard E., Collins S., Ndlovu N., Subkovas E., Karthikeyan V., Waggett L., Wood A., Bolger A., Stockport J., Evans L., Harman E., Starling J., Williams L., Saul V., Sinha M., Bell L., Tudgay S., Kemp S., Frost L., Ingram T., Loughlin A., Adams C., Adams M., Hurford F., Owen C., Miller C., Donaldson D., Tivenan H., Button H., Nasser A., Jhagra O., Stidolph B., Brown C., Livingstone C., Duffy M., Madgwick P., Roberts P., Greenwood E., Fletcher L., Beveridge M., Earles S., McKenzie D., Beacock D., Dayer M., Seddon M., Greenwell D., Luxton F., Venn F., Mills H., Rewbury J., James K., Roberts K., Tonks L., Felmeden D., Taggu W., Summerhayes A., Hughes D., Sutton J., Felmeden L., Khan M., Walker E., Norris L., O'Donohoe L., Mozid A., Dymond H., Lloyd-Jones H., Saunders G., Simmons D., Coles D., Cotterill D., Beech S., Kidd S., Wrigley B., Petkar S., Smallwood A., Jones R., Radford E., Milgate S., Metherell S., Cottam V., Buckley C., Broadley A., Wood D., Allison J., Rennie K., Balian L., Howard L., Pippard L., Board S., Pitt-Kerby T., UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, Ding W.Y., Potpara T.S., Blomstrom-Lundqvist C., Boriani G., Marin F., Fauchier L., Lip G.Y.H., Tavazzi L., Maggioni A.P., Dan G.-A., Potpara T., Nabauer M., Kalarus Z., Goda A., Mairesse G., Shalganov T., Antoniades L., Taborsky M., Riahi S., Muda P., Garcia Bolao I., Piot O., Etsadashvili K., Simantirakis E., Haim M., Azhari A., Najafian J., Santini M., Mirrakhimov E., Kulzida K., Erglis A., Poposka L., Burg M., Crijns H., Erkuner O., Atar D., Lenarczyk R., Martins Oliveira M., Shah D., Serdechnaya E., Diker E., Lane D., Zera E., Ekmekciu U., Paparisto V., Tase M., Gjergo H., Dragoti J., Ciutea M., Ahadi N., Husseini Z.E., Raepers M., Leroy J., Haushan P., Jourdan A., Lepiece C., Desteghe L., Vijgen J., Koopman P., Van Genechten G., Heidbuchel H., Boussy T., De Coninck M., Van Eeckhoutte H., Bouckaert N., Friart A., Boreux J., Arend C., Evrard P., Stefan L., Hoffer E., Herzet J., Massoz M., Celentano C., Sprynger M., Pierard L., Melon P., Van Hauwaert B., Kuppens C., Faes D., Van Lier D., Van Dorpe A., Gerardy A., Deceuninck O., Xhaet O., Dormal F., Ballant E., Blommaert D., Yakova D., Hristov M., Yncheva T., Stancheva N., Tisheva S., Tokmakova M., Nikolov F., Gencheva D., Kunev B., Stoyanov M., Marchov D., Gelev V., Traykov V., Kisheva A., Tsvyatkov H., Shtereva R., Bakalska-Georgieva S., Slavcheva S., Yotov Y., Kubickova M., Marni Joensen A., Gammelmark A., Hvilsted Rasmussen L., Dinesen P., Krogh Veno S., Sorensen B., Korsgaard A., Andersen K., Fragtrup Hellum C., Svenningsen A., Nyvad O., Wiggers P., May O., Aarup A., Graversen B., Jensen L., Andersen M., Svejgaard M., Vester S., Hansen S., Lynggaard V., Ciudad M., Vettus R., Maestre A., Castano S., Cheggour S., Poulard J., Mouquet V., Leparree S., Bouet J., Taieb J., Doucy A., Duquenne H., Furber A., Dupuis J., Rautureau J., Font M., Damiano P., Lacrimini M., Abalea J., Boismal S., Menez T., Mansourati J., Range G., Gorka H., Laure C., Vassaliere C., Elbaz N., Lellouche N., Djouadi K., Roubille F., Dietz D., Davy J., Granier M., Winum P., Leperchois-Jacquey C., Kassim H., Marijon E., Le Heuzey J., Fedida J., Maupain C., Himbert C., Gandjbakhch E., Hidden-Lucet F., Duthoit G., Badenco N., Chastre T., Waintraub X., Oudihat M., Lacoste J., Stephan C., Bader H., Delarche N., Giry L., Arnaud D., Lopez C., Boury F., Brunello I., Lefevre M., Mingam R., Haissaguerre M., Le Bidan M., Pavin D., Le Moal V., Leclercq C., Beitar T., Martel I., Schmid A., Sadki N., Romeyer-Bouchard C., Da Costa A., Arnault I., Boyer M., Piat C., Lozance N., Nastevska S., Doneva A., Fortomaroska Milevska B., Sheshoski B., Petroska K., Taneska N., Bakrecheski N., Lazarovska K., Jovevska S., Ristovski V., Antovski A., Lazarova E., Kotlar I., Taleski J., Kedev S., Zlatanovik N., Jordanova S., Bajraktarova Proseva T., Doncovska S., Maisuradze D., Esakia A., Sagirashvili E., Lartsuliani K., Natelashvili N., Gumberidze N., Gvenetadze R., Gotonelia N., Kuridze N., Papiashvili G., Menabde I., Gloggler S., Napp A., Lebherz C., Romero H., Schmitz K., Berger M., Zink M., Koster S., Sachse J., Vonderhagen E., Soiron G., Mischke K., Reith R., Schneider M., Rieker W., Boscher D., Taschareck A., Beer A., Oster D., Ritter O., Adamczewski J., Walter S., Frommhold A., Luckner E., Richter J., Schellner M., Landgraf S., Bartholome S., Naumann R., Schoeler J., Westermeier D., William F., Wilhelm K., Maerkl M., Oekinghaus R., Denart M., Kriete M., Tebbe U., Scheibner T., Gruber M., Gerlach A., Beckendorf C., Anneken L., Arnold M., Lengerer S., Bal Z., Uecker C., Fortsch H., Fechner S., Mages V., Martens E., Methe H., Schmidt T., Schaeffer B., Hoffmann B., Moser J., Heitmann K., Willems S., Klaus C., Lange I., Durak M., Esen E., Mibach F., Mibach H., Utech A., Gabelmann M., Stumm R., Landle V., Gartner C., Goerg C., Kaul N., Messer S., Burkhardt D., Sander C., Orthen R., Kaes S., Baumer A., Dodos F., Barth A., Schaeffer G., Gaertner J., Winkler J., Fahrig A., Aring J., Wenzel I., Steiner S., Kliesch A., Kratz E., Winter K., Schneider P., Haag A., Mutscher I., Bosch R., Taggeselle J., Meixner S., Schnabel A., Shamalla A., Hotz H., Korinth A., Rheinert C., Mehltretter G., Schon B., Schon N., Starflinger A., Englmann E., Baytok G., Laschinger T., Ritscher G., Gerth A., Dechering D., Eckardt L., Kuhlmann M., Proskynitopoulos N., Brunn J., Foth K., Axthelm C., Hohensee H., Eberhard K., Turbanisch S., Hassler N., Koestler A., Stenzel G., Kschiwan D., Schwefer M., Neiner S., Hettwer S., Haeussler-Schuchardt M., Degenhardt R., Sennhenn S., Brendel M., Stoehr A., Widjaja W., Loehndorf S., Logemann A., Hoskamp J., Grundt J., Block M., Ulrych R., Reithmeier A., Panagopoulos V., Martignani C., Bernucci D., Fantecchi E., Diemberger I., Ziacchi M., Biffi M., Cimaglia P., Frisoni J., Giannini I., Boni S., Fumagalli S., Pupo S., Di Chiara A., Mirone P., Pesce F., Zoccali C., Malavasi V.L., Mussagaliyeva A., Ahyt B., Salihova Z., Koshum-Bayeva K., Kerimkulova A., Bairamukova A., Lurina B., Zuzans R., Jegere S., Mintale I., Kupics K., Jubele K., Kalejs O., Vanhear K., Cachia M., Abela E., Warwicker S., Tabone T., Xuereb R., Asanovic D., Drakalovic D., Vukmirovic M., Pavlovic N., Music L., Bulatovic N., Boskovic A., Uiterwaal H., Bijsterveld N., De Groot J., Neefs J., van den Berg N., Piersma F., Wilde A., Hagens V., Van Es J., van Opstal J., Van Rennes B., Verheij H., Breukers W., Tjeerdsma G., Nijmeijer R., Wegink D., Binnema R., Said S., Philippens S., van Doorn W., Szili-Torok T., Bhagwandien R., Janse P., Muskens A., van Eck M., Gevers R., van der Ven N., Duygun A., Rahel B., Meeder J., Vold A., Holst Hansen C., Engset I., Dyduch-Fejklowicz B., Koba E., Cichocka M., Sokal A., Kubicius A., Pruchniewicz E., Kowalik-Sztylc A., Czapla W., Mroz I., Kozlowski M., Pawlowski T., Tendera M., Winiarska-Filipek A., Fidyk A., Slowikowski A., Haberka M., Lachor-Broda M., Biedron M., Gasior Z., Kolodziej M., Janion M., Gorczyca-Michta I., Wozakowska-Kaplon B., Stasiak M., Jakubowski P., Ciurus T., Drozdz J., Simiera M., Zajac P., Wcislo T., Zycinski P., Kasprzak J., Olejnik A., Harc-Dyl E., Miarka J., Pasieka M., Zieminska-Luc M., Bujak W., Sliwinski A., Grech A., Morka J., Petrykowska K., Prasal M., Hordynski G., Feusette P., Lipski P., Wester A., Streb W., Romanek J., Wozniak P., Chlebus M., Szafarz P., Stanik W., Zakrzewski M., Kazmierczak J., Przybylska A., Skorek E., Blaszczyk H., Stepien M., Szabowski S., Krysiak W., Szymanska M., Karasinski J., Blicharz J., Skura M., Halas K., Michalczyk L., Orski Z., Krzyzanowski K., Skrobowski A., Zielinski L., Tomaszewska-Kiecana M., Dluzniewski M., Kiliszek M., Peller M., Budnik M., Balsam P., Opolski G., Tyminska A., Ozieranski K., Wancerz A., Borowiec A., Majos E., Dabrowski R., Szwed H., Musialik-Lydka A., Leopold-Jadczyk A., Jedrzejczyk-Patej E., Koziel M., Mazurek M., Krzemien-Wolska K., Starosta P., Nowalany-Kozielska E., Orzechowska A., Szpot M., Staszel M., Almeida S., Pereira H., Brandao Alves L., Miranda R., Ribeiro L., Costa F., Morgado F., Carmo P., Galvao Santos P., Bernardo R., Adragao P., Ferreira da Silva G., Peres M., Alves M., Leal M., Cordeiro A., Magalhaes P., Fontes P., Leao S., Delgado A., Costa A., Marmelo B., Rodrigues B., Moreira D., Santos J., Santos L., Terchet A., Darabantiu D., Mercea S., Turcin Halka V., Pop Moldovan A., Gabor A., Doka B., Catanescu G., Rus H., Oboroceanu L., Bobescu E., Popescu R., Dan A., Buzea A., Daha I., Dan G., Neuhoff I., Baluta M., Ploesteanu R., Dumitrache N., Vintila M., Daraban A., Japie C., Badila E., Tewelde H., Hostiuc M., Frunza S., Tintea E., Bartos D., Ciobanu A., Popescu I., Toma N., Gherghinescu C., Cretu D., Patrascu N., Stoicescu C., Udroiu C., Bicescu G., Vintila V., Vinereanu D., Cinteza M., Rimbas R., Grecu M., Cozma A., Boros F., Ille M., Tica O., Tor R., Corina A., Jeewooth A., Maria B., Georgiana C., Natalia C., Alin D., Dinu-Andrei D., Livia M., Daniela R., Larisa R., Umaar S., Tamara T., Ioachim Popescu M., Nistor D., Sus I., Coborosanu O., Alina-Ramona N., Dan R., Petrescu L., Ionescu G., Vacarescu C., Goanta E., Mangea M., Ionac A., Mornos C., Cozma D., Pescariu S., Solodovnicova E., Soldatova I., Shutova J., Tjuleneva L., Zubova T., Uskov V., Obukhov D., Rusanova G., Isakova N., Odinsova S., Arhipova T., Kazakevich E., Zavyalova O., Novikova T., Riabaia I., Zhigalov S., Drozdova E., Luchkina I., Monogarova Y., Hegya D., Rodionova L., Nevzorova V., Lusanova O., Arandjelovic A., Toncev D., Vukmirovic L., Radisavljevic M., Milanov M., Sekularac N., Zdravkovic M., Hinic S., Dimkovic S., Acimovic T., Saric J., Radovanovic S., Kocijancic A., Obrenovic-Kircanski B., Kalimanovska Ostric D., Simic D., Jovanovic I., Petrovic I., Polovina M., Vukicevic M., Tomasevic M., Mujovic N., Radivojevic N., Petrovic O., Aleksandric S., Kovacevic V., Mijatovic Z., Ivanovic B., Tesic M., Ristic A., Vujisic-Tesic B., Nedeljkovic M., Karadzic A., Uscumlic A., Prodanovic M., Zlatar M., Asanin M., Bisenic B., Vasic V., Popovic Z., Djikic D., Sipic M., Peric V., Dejanovic B., Milosevic N., Backovic S., Stevanovic A., Andric A., Pencic B., Pavlovic-Kleut M., Celic V., Pavlovic M., Petrovic M., Vuleta M., Petrovic N., Simovic S., Savovic Z., Milanov S., Davidovic G., Iric-Cupic V., Djordjevic D., Damjanovic M., Zdravkovic S., Topic V., Stanojevic D., Randjelovic M., Jankovic-Tomasevic R., Atanaskovic V., Antic S., Simonovic D., Stojanovic M., Stojanovic S., Mitic V., Ilic V., Petrovic D., Deljanin Ilic M., Ilic S., Stoickov V., Markovic S., Mijatovic A., Tanasic D., Radakovic G., Peranovic J., Panic-Jelic N., Vujadinovic O., Pajic P., Bekic S., Kovacevic S., Garcia Fernandez A., Perez Cabeza A., Anguita M., Tercedor Sanchez L., Mau E., Loayssa J., Ayarra M., Carpintero M., Roldan Rabadan I., Gil Ortega M., Tello Montoliu A., Orenes Pinero E., Manzano Fernandez S., Romero Aniorte A., Veliz Martinez A., Quintana Giner M., Ballesteros G., Palacio M., Alcalde O., Garcia-Bolao I., Bertomeu Gonzalez V., Otero-Ravina F., Garcia Seara J., Gonzalez Juanatey J., Dayal N., Maziarski P., Gentil-Baron P., Koc M., Onrat E., Dural I.E., Yilmaz K., Ozin B., Tan Kurklu S., Atmaca Y., Canpolat U., Tokgozoglu L., Dolu A.K., Demirtas B., Sahin D., Ozcan Celebi O., Gagirci G., Turk U.O., Ari H., Polat N., Toprak N., Sucu M., Akin Serdar O., Taha Alper A., Kepez A., Yuksel Y., Uzunselvi A., Yuksel S., Sahin M., Kayapinar O., Ozcan T., Kaya H., Yilmaz M.B., Kutlu M., Demir M., Gibbs C., Kaminskiene S., Bryce M., Skinner A., Belcher G., Hunt J., Stancombe L., Holbrook B., Peters C., Tettersell S., Shantsila A., Senoo K., Proietti M., Russell K., Domingos P., Hussain S., Partridge J., Haynes R., Bahadur S., Brown R., McMahon S., McDonald J., Balachandran K., Singh R., Garg S., Desai H., Davies K., Goddard W., Galasko G., Rahman I., Chua Y., Payne O., Preston S., Brennan O., Pedley L., Whiteside C., Dickinson C., Brown J., Jones K., Benham L., Brady R., Buchanan L., Ashton A., Crowther H., Fairlamb H., Thornthwaite S., Relph C., McSkeane A., Poultney U., Kelsall N., Rice P., Wilson T., Wrigley M., Kaba R., Patel T., Young E., Law J., Runnett C., Thomas H., McKie H., Fuller J., Pick S., Sharp A., Hunt A., Thorpe K., Hardman C., Cusack E., Adams L., Hough M., Keenan S., Bowring A., Watts J., Zaman J., Goffin K., Nutt H., Beerachee Y., Featherstone J., Mills C., Pearson J., Stephenson L., Grant S., Wilson A., Hawksworth C., Alam I., Robinson M., Ryan S., Egdell R., Gibson E., Holland M., Leonard D., Mishra B., Ahmad S., Randall H., Hill J., Reid L., George M., McKinley S., Brockway L., Milligan W., Sobolewska J., Muir J., Tuckis L., Winstanley L., Jacob P., Kaye S., Morby L., Jan A., Sewell T., Boos C., Wadams B., Cope C., Jefferey P., Andrews N., Getty A., Suttling A., Turner C., Hudson K., Austin R., Howe S., Iqbal R., Gandhi N., Brophy K., Mirza P., Willard E., Collins S., Ndlovu N., Subkovas E., Karthikeyan V., Waggett L., Wood A., Bolger A., Stockport J., Evans L., Harman E., Starling J., Williams L., Saul V., Sinha M., Bell L., Tudgay S., Kemp S., Frost L., Ingram T., Loughlin A., Adams C., Adams M., Hurford F., Owen C., Miller C., Donaldson D., Tivenan H., Button H., Nasser A., Jhagra O., Stidolph B., Brown C., Livingstone C., Duffy M., Madgwick P., Roberts P., Greenwood E., Fletcher L., Beveridge M., Earles S., McKenzie D., Beacock D., Dayer M., Seddon M., Greenwell D., Luxton F., Venn F., Mills H., Rewbury J., James K., Roberts K., Tonks L., Felmeden D., Taggu W., Summerhayes A., Hughes D., Sutton J., Felmeden L., Khan M., Walker E., Norris L., O'Donohoe L., Mozid A., Dymond H., Lloyd-Jones H., Saunders G., Simmons D., Coles D., Cotterill D., Beech S., Kidd S., Wrigley B., Petkar S., Smallwood A., Jones R., Radford E., Milgate S., Metherell S., Cottam V., Buckley C., Broadley A., Wood D., Allison J., Rennie K., Balian L., Howard L., Pippard L., Board S., Pitt-Kerby T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, and Radiology and nuclear medicine
- Subjects
Male ,Medicin och hälsovetenskap ,Clinical Biochemistry ,Hemorrhage ,Medical and Health Sciences ,Biochemistry ,Brain Ischemia ,Risk Factors ,Hemorrhage/chemically induced ,death ,Humans ,Acute Coronary Syndrome/complications ,atrial fibrillation ,Renal Insufficiency ,Registries ,Acute Coronary Syndrome ,Renal Insufficiency/chemically induced ,Anticoagulants ,General Medicine ,thromboembolism ,kidney failure ,Stroke ,Anticoagulants/therapeutic use ,major bleeding ,outcome ,Female ,Atrial Fibrillation/complications ,chronic kidney disease ,Stroke/complications - Abstract
Background: Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF. Methods: We utilised the ESC-EHRA EORP-AF Long-Term General Registry. Outcomes were analysed according to renal function by CKD-EPI equation. The primary endpoint was a composite of thromboembolism, major bleeding, acute coronary syndrome and all-cause death. Secondary endpoints were each of these separately including ischaemic stroke, haemorrhagic event, intracranial haemorrhage, cardiovascular death and hospital admission. Results: A total of 9306 patients were included. The distribution of patients with no, mild, moderate and severe renal impairment at baseline were 16.9%, 49.3%, 30% and 3.8%, respectively. AF patients with impaired renal function were older, more likely to be females, had worse cardiac imaging parameters and multiple comorbidities. Among patients with an indication for anticoagulation, prescription of these agents was reduced in those with severe renal impairment, p 2 decrease), that was most notable in patients with eGFR 2 (HR 2.21 [95% CI, 1.23–3.99] compared to eGFR ≥90 ml/min/1.73 m 2). Conclusion: A significant proportion of patients with AF suffer from concomitant renal impairment which impacts their overall management. Furthermore, renal impairment is an independent predictor of major adverse events including thromboembolism, major bleeding, acute coronary syndrome and all-cause death in patients with AF.
- Published
- 2022
3. OP13.01: *Effective aspirin treatment for women at risk of pre‐eclampsia delays the metabolic clock of gestation.
- Author
-
Hoang, L. Nguyen, Kovacevic, V., Tlaye, K., Milosavljevic, A., Elsea, S., Fernando, S., Syngelaki, A., Nicolaides, K., Wang, C., and Poon, L.C.
- Subjects
- *
FATTY acids , *OBSTETRICS , *DISCRIMINANT analysis , *GESTATIONAL age , *ASPIRIN - Abstract
This article, titled "Effective aspirin treatment for women at risk of pre-eclampsia delays the metabolic clock of gestation," examines the impact of low-dose aspirin on the metabolic gestational clock in high-risk women for pre-eclampsia. The study analyzed plasma samples from two trials, one with aspirin-treated women and the other with placebo-treated women. The results showed that aspirin significantly decreased the metabolic clock of gestation, suggesting that it delays the gestational age at delivery with pre-eclampsia. The findings provide support for the use of aspirin in high-risk pregnancies. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
4. Clinical utility and prognostic implications of the novel 4S-AF scheme to characterize and evaluate patients with atrial fibrillation:a report from ESC-EHRA EORP-AF Long-Term General Registry
- Author
-
Ding, Wern Yew, Proietti, Marco, Boriani, Giuseppe, Fauchier, Laurent, Blomström-Lundqvist, Carina, Marin, Francisco, Potpara, Tatjana S., Lip, Gregory Y. H., Boriani, G., Lip, G. Y. H., Tavazzi, L., Maggioni, A. P., Dan, G. A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Fauchier, L., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K. A., Erglis, A., Poposka, L., Burg, M., Crijns, H., Erküner, Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., van Genechten, G., Heidbuchel, H., Boussy, T., de Coninck, M., van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., van Hauwaert, B., Kuppens, C., Faes, D., van Lier, D., van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., le Bidan, M., Pavin, D., le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V. L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., de Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., van Es, J., van Opstal, J., van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-ŁUć, M., Bujak, W., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stȩpień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, C. F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Mijatovic, S. A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I. E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A. K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U. O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Ozcan, O. T., Kaya, H., Yilmaz, M. B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, Radiology and nuclear medicine, Laboratory Medicine, Cardiology, and ACS - Heart failure & arrhythmias
- Subjects
Characterization ,Bleeding ,4S-AF ,Atrial fibrillation ,Classification ,EORP-AF registry ,Mortality ,Prognostic implications ,Stroke ,Thromboembolism ,Validation ,Anticoagulants ,Hemorrhage ,Humans ,Prognosis ,Registries ,Risk Factors ,Atrial Fibrillation ,Brain Ischemia ,Ischemic Stroke ,Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Aims The 4S-AF classification scheme comprises of four domains: stroke risk (St), symptoms (Sy), severity of atrial fibrillation (AF) burden (Sb), and substrate (Su). We sought to examine the implementation of the 4S-AF scheme in the EORP-AF General Long-Term Registry and compare outcomes in AF patients according to the 4S-AF-led decision-making process. Methods and results Atrial fibrillation patients from 250 centres across 27 European countries were included. A 4S-AF score was calculated as the sum of each domain with a maximum score of 9. Of 6321 patients, 8.4% had low (St), 47.5% EHRA I (Sy), 40.5% newly diagnosed or paroxysmal AF (Sb), and 5.1% no cardiovascular risk factors or left atrial enlargement (Su). Median follow-up was 24 months. Using multivariable Cox regression analysis, independent predictors of all-cause mortality were (St) [adjusted hazard ratio (aHR) 8.21, 95% confidence interval (CI): 2.60–25.9], (Sb) (aHR 1.21, 95% CI: 1.08–1.35), and (Su) (aHR 1.27, 95% CI: 1.14–1.41). For CV mortality and any thromboembolic event, only (Su) (aHR 1.73, 95% CI: 1.45–2.06) and (Sy) (aHR 1.29, 95% CI: 1.00–1.66) were statistically significant, respectively. None of the domains were independently linked to ischaemic stroke or major bleeding. Higher 4S-AF score was related to a significant increase in all-cause mortality, CV mortality, any thromboembolic event, and ischaemic stroke but not major bleeding. Treatment of all 4S-AF domains was associated with an independent decrease in all-cause mortality (aHR 0.71, 95% CI: 0.55–0.92). For each 4S-AF domain left untreated, the risk of all-cause mortality increased substantially (aHR 1.35, 95% CI: 1.16–1.56). Conclusion Implementation of the novel 4S-AF scheme is feasible, and treatment decisions based on this scheme improve mortality rates in AF.
- Published
- 2022
5. Procedures performed during neurosurgery residency in Europe
- Author
-
Stienen, M. N., Freyschlag, C. F., Schaller, K., Meling, T., Al-Amin, A., Al-Mahfoudh, R., Amelot, A., Arvidsson, L., Athanasiou, A., Avellan, C. I. A., Bauchet, L., Berilazic, L., Bolger, C., Bourdillon, P., Boviatsis, S., Bozinov, O., Branco, P., Braunsdorf, W., Cahill, J., Clusmann, H., Conrad, J., Cordier, D., Cristino, N., Djilvesi, D., Duerinck, J., Dumot, C., Durak, M. A., Eisenring, C. V., Esposito, G., Finiels, P. -J., Flaskas, T., Fuentes, S., Ganau, M., Georgiadis, I., Georgiopoulos, M., Giakoumettis, D., Gilis, N., Gradil, C., Grau, S. J., Grin, A., Hadjigeorgiou, G., Halatsch, M. -E., Hecht, N., Holling, M., Ilic, R., Iken, L., Santos, N. I., Jacquesson, T., Jalloh, I., Jelaca, B., Kaestner, S., Kalasauskas, D., Kaliyev, A., Kleiber, J. -C., Konczalla, J., Kothbauer, K. F., Kovacevic, V., Krajcinovic, N., Krieg, S. M., Kamarainen, O. -P., Lapcic, M., Lapras, C., Ljungqvist, J., W. B., Lo, Lubrano, V., Majovsky, M., Manet, R., Marchi, F., Medetov, Y., Meling, T. R., Melloni, I., Melot, A., Mertens, P., Metcalfe, S., Moerkve, S. H., Mora, A. R., Musabelliu, E., Naushahi, M. J., Nurzhan, A., Omerhodzic, I., Paldor, I., Pallud, J., Papanastassiou, V., Papic, V., Paschalis, T., Payer, M., Peerdeman, S. M., Peruzzi, P., Segerlind, J. P., Posti, J. P., Proust, F., Regli, L., Rinne, J., Roche, P. -H., Rocka, S., Rotermund, R., Rutherford, S. A., Ratsep, T., Ruter, A., Saarenpaa, I. M., Samanci, M. Y., Samardzic, M., Sampron, N., Sandvik, U., Scerrati, A., Schneider, M., Schul, D. B., Sengul, G., Simon, E., Sinha, S., Solheim, O., Spatola, G., Spektor, S., Sundblom, J., Syrmos, N. C., Teo, M., Thomson, S., Tonchev, N., Tosic, L., Vandertop, W. P., von der Brelie, C., Vuk, A., Walkden, J., Wendel, C., Yaqout, M., Yusupova, M., Zollino, G., University of Zurich, Surgical clinical sciences, Neuroprotection & Neuromodulation, Neurosurgery, IOO, and ANS - Systems & Network Neuroscience
- Subjects
Adult ,Male ,Neurosurgery/education ,medicine.medical_specialty ,Certification ,Caseload ,Europe ,Neurosurgery ,Residency ,Training program ,Working hour restriction ,610 Medicine & health ,Neurosurgical Procedures ,NO ,03 medical and health sciences ,10180 Clinic for Neurosurgery ,0302 clinical medicine ,Surveys and Questionnaires ,Germany ,Medicine ,Humans ,Child ,Greece ,business.industry ,Female sex ,Internship and Residency ,Mean age ,Surgical procedures ,Middle Aged ,Current analysis ,United Kingdom ,Original Article - Neurosurgery Training ,ddc:616.8 ,030220 oncology & carcinogenesis ,Surgery ,Female ,Neurology (clinical) ,France ,business ,030217 neurology & neurosurgery ,Switzerland ,Demography - Abstract
Background In a previous article (10.1007/s00701-019-03888-3), preliminary results of a survey, aiming to shed light on the number of surgical procedures performed and assisted during neurosurgery residency in Europe were reported. We here present the final results and extend the analyses. Methods Board-certified neurosurgeons of European Association of Neurosurgical Societies (EANS) member countries were asked to review their residency case logs and participate in a 31-question electronic survey (SurveyMonkey Inc., San Mateo, CA). The responses received between April 25, 2018, and April 25, 2020, were considered. We excluded responses that were incomplete, from non-EANS member countries, or from respondents that have not yet completed their residency. Results Of 430 responses, 168 were considered for analysis after checking in- and exclusion criteria. Survey responders had a mean age of 42.7 ± 8.8 years, and 88.8% were male. Responses mainly came from surgeons employed at university/teaching hospitals (85.1%) in Germany (22.0%), France (12.5%), the United Kingdom (UK; 8.3%), Switzerland (7.7%), and Greece (7.1%). Most responders graduated in the years between 2011 and 2019 (57.7%). Thirty-eight responders (22.6%) graduated before and 130 responders (77.4%) after the European WTD 2003/88/EC came into effect. The mean number of surgical procedures performed independently, supervised or assisted throughout residency was 540 (95% CI 424–657), 482 (95% CI 398–568), and 579 (95% CI 441–717), respectively. Detailed numbers for cranial, spinal, adult, and pediatric subgroups are presented in the article. There was an annual decrease of about 33 cases in total caseload between 1976 and 2019 (coeff. − 33, 95% CI − 62 to − 4, p = 0.025). Variables associated with lesser total caseload during residency were training abroad (1210 vs. 1747, p = 0.083) and female sex by trend (947 vs. 1671, p = 0.111), whereas case numbers were comparable across the EANS countries (p = 0.443). Conclusion The final results of this survey largely confirm the previously reported numbers. They provide an opportunity for current trainees to compare their own case logs with. Again, we confirm a significant decline in surgical exposure during training between 1976 and 2019. In addition, the current analysis reveals that female sex and training abroad may be variables associated with lesser case numbers during residency.
- Published
- 2020
6. INFLUENCES OF SOIL AND FERTILIZATION WITH PHOSPHORUS AND POTASSIUM ON ZINC, MANGANESE, COPPER AND IRON STATUS IN MAIZE
- Author
-
JURKOVIC, Z., KOVACEVIC, V., LONCARIC, Z., and ZDUNIC, Z.
- Published
- 2006
7. PHOSPHORUS IMPACTS ON YIELD AND NUTRITIONAL STATUS OF MAIZE
- Author
-
BANAJ, D., KOVACEVIC, V., SIMIC, D., SEPUT, M., and STOJIC, B.
- Published
- 2006
8. INFLUENCES OF LIMING ON MAIZE, SUNFLOWER AND BARLEY
- Author
-
KOVACEVIC, V., BANAJ, D., KOVACEVIC, J., LALIC, A., JURKOVIC, Z., and KRIZMANIC, M.
- Published
- 2006
9. Response of maize to fertilization with KCl on gleysol of Sava valley area
- Author
-
Kovačević, V., Rastija, M., Rastija, D., Josipović, M., and Šeput, M.
- Published
- 2006
10. INFLUENCES OF FERTILIZATION ON YIELD AND NUTRITIONAL STATUS OF MAIZE
- Author
-
LONCARIC, Z., KOVACEVIC, V., SEPUT, Miranda, SIMIC, B., and STOJIC, Biserka
- Published
- 2005
11. FERTILIZATION IMPACTS ON THE YIELD AND NUTRITIONAL STATUS OF MAIZE (Zea mays L.)
- Author
-
KOVAČEVIĆ, V., BANAJ, D., BRKIĆ, I., ANTUNOVIĆ, M., and PETOŠIĆ, D.
- Published
- 2004
12. Main determinants of physician-driven amiodarone discontinuation in clinical practice
- Author
-
Mihajlovic, M, primary, Mihajlovic, A, additional, Marinkovic, M, additional, Kovacevic, V, additional, Simic, J, additional, Mujovic, N, additional, and Potpara, T, additional
- Published
- 2021
- Full Text
- View/download PDF
13. Sex-related differences in self-reported treatment burden in patients with atrial fibrillation
- Author
-
Mihajlovic, M, primary, Simic, J, additional, Marinkovic, M, additional, Kovacevic, V, additional, Kocijancic, A, additional, Mujovic, N, additional, and Potpara, T, additional
- Published
- 2021
- Full Text
- View/download PDF
14. Magnesium Status in Corn (Zea Mays L.) Hybrids and Its Relations to Potassium and Calcium
- Author
-
Kovacevic, V., Brkic, I., Banaj, D., Antunovic, M., Simic, D., and Petosic, D.
- Published
- 2004
- Full Text
- View/download PDF
15. P1886Validation of the MB-LATER score prediction ability for recurrent atrial fibrillation after electrical cardioversion
- Author
-
Marinkovic, M, primary, Mujovic, N, additional, Kovacevic, V, additional, Mihajlovic, M, additional, Vajagic, L, additional, Kocijancic, A, additional, Olafsson, U, additional, Andersen, K, additional, Arnar, D O, additional, Lip, G Y H, additional, and Potpara, T, additional
- Published
- 2019
- Full Text
- View/download PDF
16. 6083Amiodarone in contemporary clinical practice: the rates of and reasons for permanent drug discontinuation
- Author
-
Mihajlovic, M, primary, Mihajlovic, A, additional, Marinkovic, M, additional, Kovacevic, V, additional, Vajagic, L, additional, Kocijancic, A, additional, Mujovic, N, additional, and Potpara, T, additional
- Published
- 2019
- Full Text
- View/download PDF
17. 3269Impact of type 2 diabetes on incidence and phenotype of heart failure in patients with atrial fibrillation
- Author
-
Polovina, M, primary, Milinkovic, I, additional, Krljanac, G, additional, Veljic, I, additional, Petrovic-Djordjevic, I, additional, Djikic, D, additional, Simic, J, additional, Pavlovic, A, additional, Kovacevic, V, additional, Asanin, M, additional, and Seferovic, P M, additional
- Published
- 2019
- Full Text
- View/download PDF
18. P1900Amiodarone treatment duration and reasons for permanent drug discontinuation in patients with atrial fibrillation
- Author
-
Mihajlovic, M, primary, Mihajlovic, A, additional, Marinkovic, M, additional, Kovacevic, V, additional, Vajagic, L, additional, Kocijancic, A, additional, Mujovic, N, additional, and Potpara, T, additional
- Published
- 2019
- Full Text
- View/download PDF
19. Spitsbergen Oceanic and Atmospheric interactions
- Author
-
Bensi, M, Kovacevic, V, Ursella, L, Rebesco, M, Langone, L, Viola, A, Mazzola, M, Beszczyńska- Möller, A, Goszczko, I, Soltwedel, T, Skogseth, R, Nilsen, F, and Wåhlin, A
- Subjects
Fram strait ,deep sea thermohaline variability ,wind-induced processes ,slope currents - Abstract
This is chapter 6 of the State of Environmental Science in Svalbard (SESS) report 2018 (https://sios-svalbard.org/SESS_Issue1). In the Fram Strait, a remarkable increase in the temperature and salinity of inflowing Atlantic Water has been observed since the 1990s. This is in part a natural trend, but recent temperature anomalies, ~1°C relative to the 1970s are related to anthropogenic causes. Air temperature increased by about 3°C in the 20th century and meteorological stations at Svalbard confirm this positive trend. At the West Spitsbergen margin, Atlantic and Arctic waters converge, mix and exchange, while air–sea interactions and shelf–slope dynamics trigger vertical mixing and formation of cold and salty water. This water is sufficiently dense to sink to greater depths and contribute to the global thermohaline circulation. The circulation process permits exchange of heat (i.e., energy) between low and high latitudes. Since the formation of dense water and its spreading at greater depths are strongly influenced by the properties of Atlantic Water, which have been changing in the last decades, we cannot exclude the possibility that the global thermohaline circulation may change in the near future. We analysed oceanographic data (obtained from shelf and deep-sea oceanographic moorings and hydrographic cruises) and meteorological data from the west Svalbard margin, comparing temperature and salinity variability in the deep ocean flow and the wind regime. Time-series revealed occasional intrusions of warm and salty waters at 1000 m depth, mainly during the period October – April, quasi-simultaneously at several locations more than 150 apart, along the continental slope west of Svalbard. The fact that the most energetic events, both in the deep flow and in the wind speed, occurred with similar periodicities (10-20 days) suggests atmospheric storms as the likely forcing mechanism underlying the observed deep sea variability. Others energetic events with periodicity of 12 and 24 hours, instead, could be related to internal tidal oscillations. The fact that the most energetic events, both in the deep flow and in the wind speed, had similar periodicities (10-20 days) suggests atmospheric storms as the likely forcing mechanism underlying the observed deep-sea variability. Other energetic events with periodicity of 12 and 24 hours could instead be related to tidal oscillations.
- Published
- 2019
- Full Text
- View/download PDF
20. Association between antithrombotic treatment and outcomes at 1-year follow-up in patients with atrial fibrillation: the EORP-AF General Long-Term Registry
- Author
-
Zakine, Cyril, Garcia, Rodrigue, Narayanan, Kumar, Gandjbakhch, Estelle, Algalarrondo, Vincent, Lellouche, Nicolas, Perier, Marie-Cécile, Fauchier, Laurent, Gras, Daniel, Bordachar, Pierre, Piot, Olivier, Babuty, Dominique, Sadoul, Nicolas, Defaye, Pascal, Deharo, Jean-Claude, Klug, Didier, Leclercq, Christophe, Extramiana, Fabrice, Boveda, Serge, Marijon, Eloi, Maury, Philippe, Alonso, Christine, Anselme, Frederic, Hermida, Jean-Sylvain, Laurent, Gabriel, Mansourati, Jacques, Sacher, Frederic, Taieb, Jérôme, Boriani, Giuseppe, Proietti, Marco, Laroche, Cécile, Marin, Francisco, Nabauer, Michael, Potpara, Tatjana, Dan, Gheorghe-Andrei, Kalarus, Zbigniew, Tavazzi, Luigi, Maggioni, Aldo, Lip, Gregory, Dan, G-A, Goda, A, Mairesse, G, Shalganov, T, Antoniades, L, Taborsky, M, Riahi, S, Muda, P, García Bolao, I, Etsadashvili, K, Simantirakis, E, Haim, M, Azhari, A, Najafian, J, Santini, M, Mirrakhimov, E, a Kulzida, K, Erglis, A, Poposka, L, Burg, M, Crijns, H, Erküner, Ö, Atar, D, Lenarczyk, R, Martins Oliveira, M, Shah, D, Serdechnaya, E, Diker, E, Lane, D, Zëra, E, Ekmekçiu, U, Paparisto, V, Tase, M, Gjergo, H, Dragoti, J, Ciutea, M, Ahadi, N, El Husseini, Z, Raepers, M, Leroy, J, Haushan, P, Jourdan, A, Lepiece, C, Desteghe, L, Vijgen, J, Koopman, P, van Genechten, G, Heidbuchel, H, Boussy, T, de Coninck, M, van Eeckhoutte, H, Bouckaert, N, Friart, A, Boreux, J, Arend, C, Evrard, P, Stefan, L, Hoffer, E, Herzet, J, Massoz, M, Celentano, C, Sprynger, M, Pierard, L, Melon, P, van Hauwaert, B, Kuppens, C, Faes, D, van Lier, D, van Dorpe, A, Gerardy, A, Deceuninck, O, Xhaet, O, Dormal, F, Ballant, E, Blommaert, D, Yakova, D, Hristov, M, Yncheva, T, Stancheva, N, Tisheva, S, Tokmakova, M, Nikolov, F, Gencheva, D, Kunev, B, Stoyanov, M, Marchov, D, Gelev, V, Traykov, V, Kisheva, A, Tsvyatkov, H, Shtereva, R, Bakalska-Georgieva, S, Slavcheva, S, Yotov, Y, Kubíčková, M, Marni Joensen, A, Gammelmark, A, Hvilsted Rasmussen, L, Dinesen, P, Krogh Venø, S, Sorensen, B, Korsgaard, A, Andersen, K, Fragtrup Hellum, C, Svenningsen, A, Nyvad, O, Wiggers, P, May, O, Aarup, A, Graversen, B, Jensen, L, Andersen, M, Svejgaard, M, Vester, S, Hansen, S, Lynggaard, V, Ciudad, M, Vettus, R, Maestre, A, Castaño, S, Cheggour, S, Poulard, J, Mouquet, V, Leparrée, S, Bouet, J, Doucy, A, Duquenne, H, Furber, A, Dupuis, J, Rautureau, J, Font, M, Damiano, P, Lacrimini, M, Abalea, J, Boismal, S, Menez, T, Range, G, Gorka, H, Laure, C, Vassalière, C, Elbaz, N, Djouadi, K, Roubille, F, Dietz, D, Davy, J, Granier, M, Winum, P, Leperchois-Jacquey, C, Kassim, H, Le Heuzey, J, Fedida, J, Maupain, C, Himbert, C, Hidden-Lucet, F, Duthoit, G, Badenco, N, Chastre, T, Waintraub, X, Oudihat, M, Lacoste, J, Stephan, C, Bader, H, Delarche, N, Giry, L, Arnaud, D, Lopez, C, Boury, F, Brunello, I, Lefèvre, M, Mingam, R, Haissaguerre, M, Le Bidan, M, Pavin, D, Le Moal, V, Beitar, T, Martel, I, Schmid, A, Sadki, N, Romeyer-Bouchard, C, da Costa, A, Arnault, I, Boyer, M, Piat, C, Lozance, N, Nastevska, S, Doneva, A, Fortomaroska Milevska, B, Sheshoski, B, Petroska, K, Taneska, N, Bakrecheski, N, Lazarovska, K, Jovevska, S, Ristovski, V, Antovski, A, Lazarova, E, Kotlar, I, Taleski, J, Kedev, S, Zlatanovik, N, Jordanova, S, Bajraktarova Proseva, T, Doncovska, S, Maisuradze, D, Esakia, A, Sagirashvili, E, Lartsuliani, K, Natelashvili, N, Gumberidze, N, Gvenetadze, R, Gotonelia, N, Kuridze, N, Papiashvili, G, Menabde, I, Glöggler, S, Napp, A, Lebherz, C, Romero, H, Schmitz, K, Berger, M, Zink, M, Köster, S, Sachse, J, Vonderhagen, E, Soiron, G, Mischke, K, Reith, R, Schneider, M, Rieker, W, Boscher, D, Taschareck, A, Beer, A, Oster, D, Ritter, O, Adamczewski, J, Walter, S, Frommhold, A, Luckner, E, Richter, J, Schellner, M, Landgraf, S, Bartholome, S, Naumann, R, Schoeler, J, Westermeier, D, William, F, Wilhelm, K, Maerkl, M, Oekinghaus, R, Denart, M, Kriete, M, Tebbe, U, Scheibner, T, Gruber, M, Gerlach, A, Beckendorf, C, Anneken, L, Arnold, M, Lengerer, S, Bal, Z, Uecker, C, Förtsch, H, Fechner, S, Mages, V, Martens, E, Methe, H, Schmidt, T, Schaeffer, B, Hoffmann, B, Moser, J, Heitmann, K, Willems, S, Klaus, C, Lange, I, Durak, M, Esen, E, Mibach, F, Mibach, H, Utech, A, Gabelmann, M, Stumm, R, Ländle, V, Gartner, C, Goerg, C, Kaul, N, Messer, S, Burkhardt, D, Sander, C, Orthen, R, Kaes, S, Baumer, A, Dodos, F, Barth, A, Schaeffer, G, Gaertner, J, Winkler, J, Fahrig, A, Aring, J, Wenzel, I, Steiner, S, Kliesch, A, Kratz, E, Winter, K, Schneider, P, Haag, A, Mutscher, I, Bosch, R, Taggeselle, J, Meixner, S, Schnabel, A, Shamalla, A, Hötz, H, Korinth, A, Rheinert, C, Mehltretter, G, Schön, B, Schön, N, Starflinger, A, Englmann, E, Baytok, G, Laschinger, T, Ritscher, G, Gerth, A, Dechering, D, Eckardt, L, Kuhlmann, M, Proskynitopoulos, N, Brunn, J, Foth, K, Axthelm, C, Hohensee, H, Eberhard, K, Turbanisch, S, Hassler, N, Koestler, A, Stenzel, G, Kschiwan, D, Schwefer, M, Neiner, S, Hettwer, S, Haeussler-Schuchardt, M, Degenhardt, R, Sennhenn, S, Brendel, M, Stoehr, A, Widjaja, W, Loehndorf, S, Logemann, A, Hoskamp, J, Grundt, J, Block, M, Ulrych, R, Reithmeier, A, Panagopoulos, V, Martignani, C, Bernucci, D, Fantecchi, E, Diemberger, I, Ziacchi, M, Biffi, M, Cimaglia, P, Frisoni, J, Giannini, I, Boni, S, Fumagalli, S, Pupo, S, Di Chiara, A, Mirone, P, Pesce, F, Zoccali, C, Malavasi, V, Mussagaliyeva, A, Ahyt, B, Salihova, Z, Koshum-Bayeva, K, Kerimkulova, A, Bairamukova, A, Lurina, B, Zuzans, R, Jegere, S, Mintale, I, Kupics, K, Jubele, K, Kalejs, O, Vanhear, K, Cachia, M, Abela, E, Warwicker, S, Tabone, T, Xuereb, R, Asanovic, D, Drakalovic, D, Vukmirovic, M, Pavlovic, N, Music, L, Bulatovic, N, Boskovic, A, Uiterwaal, H, Bijsterveld, N, de Groot, J, Neefs, J, van den Berg, N, Piersma, F, Wilde, A, Hagens, V, van Es, J, van Opstal, J, van Rennes, B, Verheij, H, Breukers, W, Tjeerdsma, G, Nijmeijer, R, Wegink, D, Binnema, R, Said, S, Philippens, S, van Doorn, W, Szili-Torok, T, Bhagwandien, R, Janse, P, Muskens, A, van Eck, M, Gevers, R, van Der Ven, N, Duygun, A, Rahel, B, Meeder, J, Vold, A, Holst Hansen, C, Engset, I, Dyduch-Fejklowicz, B, Koba, E, Cichocka, M, Sokal, A, Kubicius, A, Pruchniewicz, E, Kowalik-Sztylc, A, Czapla, W, Mróz, I, Kozlowski, M, Pawlowski, T, Tendera, M, Winiarska-Filipek, A, Fidyk, A, Slowikowski, A, Haberka, M, Lachor-Broda, M, Biedron, M, Gasior, Z, Kołodziej, M, Janion, M, Gorczyca-Michta, I, Wozakowska-Kaplon, B, Stasiak, M, Jakubowski, P, Ciurus, T, Drozdz, J, Simiera, M, Zajac, P, Wcislo, T, Zycinski, P, Kasprzak, J, Olejnik, A, Harc-Dyl, E, Miarka, J, Pasieka, M, Ziemińska-Łuć, M, Bujak, W, Śliwiński, A, Grech, A, Morka, J, Petrykowska, K, Prasał, M, Hordyński, G, Feusette, P, Lipski, P, Wester, A, Streb, W, Romanek, J, Woźniak, P, Chlebuś, M, Szafarz, P, Stanik, W, Zakrzewski, M, Kaźmierczak, J, Przybylska, A, Skorek, E, Błaszczyk, H, Stępień, M, Szabowski, S, Krysiak, W, Szymańska, M, Karasiński, J, Blicharz, J, Skura, M, Hałas, K, Michalczyk, L, Orski, Z, Krzyżanowski, K, Skrobowski, A, Zieliński, L, Tomaszewska-Kiecana, M, Dłużniewski, M, Kiliszek, M, Peller, M, Budnik, M, Balsam, P, Opolski, G, Tymińska, A, Ozierański, K, Wancerz, A, Borowiec, A, Majos, E, Dabrowski, R, Szwed, H, Musialik-Lydka, A, Leopold-Jadczyk, A, Jedrzejczyk-Patej, E, Koziel, M, Mazurek, M, Krzemien-Wolska, K, Starosta, P, Nowalany-Kozielska, E, Orzechowska, A, Szpot, M, Staszel, M, Almeida, S, Pereira, H, Brandão Alves, L, Miranda, R, Ribeiro, L, Costa, F, Morgado, F, Carmo, P, Galvao Santos, P, Bernardo, R, Adragão, P, Ferreira da Silva, G, Peres, M, Alves, M, Leal, M, Cordeiro, A, Magalhães, P, Fontes, P, Leão, S, Delgado, A, Costa, A, Marmelo, B, Rodrigues, B, Moreira, D, Santos, J, Santos, L, Terchet, A, Darabantiu, D, Mercea, S, Turcin Halka, V, Pop Moldovan, A, Gabor, A, Doka, B, Catanescu, G, Rus, H, Oboroceanu, L, Bobescu, E, Popescu, R, Dan, A, Buzea, A, Daha, I, Neuhoff, I, Baluta, M, Ploesteanu, R, Dumitrache, N, Vintila, M, Daraban, A, Japie, C, Badila, E, Tewelde, H, Hostiuc, M, Frunza, S, Tintea, E, Bartos, D, Ciobanu, A, Popescu, I, Toma, N, Gherghinescu, C, Cretu, D, Patrascu, N, Stoicescu, C, Udroiu, C, Bicescu, G, Vintila, V, Vinereanu, D, Cinteza, M, Rimbas, R, Grecu, M, Cozma, A, Boros, F, Ille, M, Tica, O, Tor, R, Corina, A, Jeewooth, A, Maria, B, Georgiana, C, Natalia, C, Alin, D, Dinu-Andrei, D, Livia, M, Daniela, R, Larisa, R, Umaar, S, Tamara, T, Ioachim Popescu, M, Nistor, D, Sus, I, Coborosanu, O, Alina-Ramona, N, Dan, R, Petrescu, L, Ionescu, G, Vacarescu, C, Goanta, E, Mangea, M, Ionac, A, Mornos, C, Cozma, D, Pescariu, S, Solodovnicova, E, Soldatova, I, Shutova, J, Tjuleneva, L, Zubova, T, Uskov, V, Obukhov, D, Rusanova, G, Isakova, N, Odinsova, S, Arhipova, T, Kazakevich, E, Zavyalova, O, Novikova, T, Riabaia, I, Zhigalov, S, Drozdova, E, Luchkina, I, Monogarova, Y, Hegya, D, Rodionova, L, Nevzorova, V, Lusanova, O, Arandjelovic, A, Toncev, D, Vukmirovic, L, Radisavljevic, M, Milanov, M, Sekularac, N, Zdravkovic, M, Hinic, S, Dimkovic, S, Acimovic, T, Saric, J, Radovanovic, S, Kocijancic, A, Obrenovic-Kircanski, B, Kalimanovska Ostric, D, Simic, D, Jovanovic, I, Petrovic, I, Polovina, M, Vukicevic, M, Tomasevic, M, Mujovic, N, Radivojevic, N, Petrovic, O, Aleksandric, S, Kovacevic, V, Mijatovic, Z, Ivanovic, B, Tesic, M, Ristic, A, Vujisic-Tesic, B, Nedeljkovic, M, Karadzic, A, Uscumlic, A, Prodanovic, M, Zlatar, M, Asanin, M, Bisenic, B, Vasic, V, Popovic, Z, Djikic, D, Sipic, M, Peric, V, Dejanovic, B, Milosevic, N, Backovic, S, Stevanovic, A, Andric, A, Pencic, B, Pavlovic-Kleut, M, Celic, V, Pavlovic, M, Petrovic, M, Vuleta, M, Petrovic, N, Simovic, S, Savovic, Z, Milanov, S, Davidovic, G, Iric-Cupic, V, Djordjevic, D, Damjanovic, M, Zdravkovic, S, Topic, V, Stanojevic, D, Randjelovic, M, Jankovic-Tomasevic, R, Atanaskovic, V, Antic, S, Simonovic, D, Stojanovic, M, Stojanovic, S, Mitic, V, Ilic, V, Petrovic, D, Deljanin Ilic, M, Ilic, S, Stoickov, V, Markovic, S, Mijatovic, A, Tanasic, D, Radakovic, G, Peranovic, J, Panic-Jelic, N, Vujadinovic, O, Pajic, P, Bekic, S, Kovacevic, S, García Fernandez, A, Perez Cabeza, A, Anguita, M, Tercedor Sanchez, L, Mau, E, Loayssa, J, Ayarra, M, Carpintero, M, Roldán Rabadan, I, Gil Ortega, M, Tello Montoliu, A, Orenes Piñero, E, Manzano Fernández, S, Romero Aniorte, A, Veliz Martínez, A, Quintana Giner, M, Ballesteros, G, Palacio, M, Alcalde, O, García-Bolao, I, Bertomeu Gonzalez, V, Otero-Raviña, F, García Seara, J, Gonzalez Juanatey, J, Dayal, N, Maziarski, P, Gentil-Baron, P, Koç, M, Onrat, E, Dural, I, Yilmaz, K, Özin, B, Tan Kurklu, S, Atmaca, Y, Canpolat, U, Tokgozoglu, L, Dolu, A, Demirtas, B, Sahin, D, Ozcan Celebi, O, Gagirci, G, Turk, U, Ari, H, Polat, N, Toprak, N, Sucu, M, Akin Serdar, O, Taha Alper, A, Kepez, A, Yuksel, Y, Uzunselvi, A, Yuksel, S, Sahin, M, Kayapinar, O, Ozcan, T, Kaya, H, Yilmaz, M, Kutlu, M, Demir, M, Gibbs, C, Kaminskiene, S, Bryce, M, Skinner, A, Belcher, G, Hunt, J, Stancombe, L, Holbrook, B, Peters, C, Tettersell, S, Shantsila, A, Senoo, K, Russell, K, Domingos, P, Hussain, S, Partridge, J, Haynes, R, Bahadur, S, Brown, R, Mcmahon, S, Mcdonald, J, Balachandran, K, Singh, R, Garg, S, Desai, H, Davies, K, Goddard, W, Galasko, G, Rahman, I, Chua, Y, Payne, O, Preston, S, Brennan, O, Pedley, L, Whiteside, C, Dickinson, C, Brown, J, Jones, K, Benham, L, Brady, R, Buchanan, L, Ashton, A, Crowther, H, Fairlamb, H, Thornthwaite, S, Relph, C, Mcskeane, A, Poultney, U, Kelsall, N, Rice, P, Wilson, T, Wrigley, M, Kaba, R, Patel, T, Young, E, Law, J, Runnett, C, Thomas, H, Mckie, H, Fuller, J, Pick, S, Sharp, A, Hunt, A, Thorpe, K, Hardman, C, Cusack, E, Adams, L, Hough, M, Keenan, S, Bowring, A, Watts, J, Zaman, J, Goffin, K, Nutt, H, Beerachee, Y, Featherstone, J, Mills, C, Pearson, J, Stephenson, L, Grant, S, Wilson, A, Hawksworth, C, Alam, I, Robinson, M, Ryan, S, Egdell, R, Gibson, E, Holland, M, Leonard, D, Mishra, B, Ahmad, S, Randall, H, Hill, J, Reid, L, George, M, Mckinley, S, Brockway, L, Milligan, W, Sobolewska, J, Muir, J, Tuckis, L, Winstanley, L, Jacob, P, Kaye, S, Morby, L, Jan, A, Sewell, T, Boos, C, Wadams, B, Cope, C, Jefferey, P, Andrews, N, Getty, A, Suttling, A, Turner, C, Hudson, K, Austin, R, Howe, S, Iqbal, R, Gandhi, N, Brophy, K, Mirza, P, Willard, E, Collins, S, Ndlovu, N, Subkovas, E, Karthikeyan, V, Waggett, L, Wood, A, Bolger, A, Stockport, J, Evans, L, Harman, E, Starling, J, Williams, L, Saul, V, Sinha, M, Bell, L, Tudgay, S, Kemp, S, Frost, L, Ingram, T, Loughlin, A, Adams, C, Adams, M, Hurford, F, Owen, C, Miller, C, Donaldson, D, Tivenan, H, Button, H, Nasser, A, Jhagra, O, Stidolph, B, Brown, C, Livingstone, C, Duffy, M, Madgwick, P, Roberts, P, Greenwood, E, Fletcher, L, Beveridge, M, Earles, S, Mckenzie, D, Beacock, D, Dayer, M, Seddon, M, Greenwell, D, Luxton, F, Venn, F, Mills, H, Rewbury, J, James, K, Roberts, K, Tonks, L, Felmeden, D, Taggu, W, Summerhayes, A, Hughes, D, Sutton, J, Felmeden, L, Khan, M, Walker, E, Norris, L, O'Donohoe, L, Mozid, A, Dymond, H, Lloyd-Jones, H, Saunders, G, Simmons, D, Coles, D, Cotterill, D, Beech, S, Kidd, S, Wrigley, B, Petkar, S, Smallwood, A, Jones, R, Radford, E, Milgate, S, Metherell, S, Cottam, V, Buckley, C, Broadley, A, Wood, D, Allison, J, Rennie, K, Balian, L, Howard, L, Pippard, L, Board, S, Pitt-Kerby, T, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Université de Montréal (UdeM), Service de cardiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de cardiologie [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), Cardiopathies et mort subite [ERL 3147], Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Biospectroscopie Translationnelle - EA 7506 (BIOSPECT), Université de Reims Champagne-Ardenne (URCA), Service de Cardiologie B, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Cardiac Stimulation and Rhythmology, CHU Grenoble, Department of Cardiology and Cardiovascular Surgery, CHU Michallon, Grenoble, France, CHU Marseille, CHU Lille, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Clinique Pasteur, Clinique Pasteur [Toulouse], Service de cardiologie [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital Ambroise Paré [AP-HP], Service de cardiologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), Centre Hospitalier du Pays d'Aix, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Università degli Studi di Milano = University of Milan (UNIMI), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Liverpool, Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Universidad de Murcia, University of Belgrade [Belgrade], Colentina University Hospital, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Silesian Medical University, Katowice, Poland, Maria Cecilia Hospital [Cotignola], Research Center [Associazione Nazionale Medici Cardiologi Ospedalieri] (ANMCO Research Center), Associazione Nazionale Medici Cardiologi Ospedalieri [Firenze] (ANMCO), Aalborg University [Denmark] (AAU), Abbott Vascular Int., Amgen Cardiovascular, Novartis Pharma AG, Sanofi, SERVIER, Atrial Fibrillation NETwork, AFNET, AstraZeneca, Bayer AG, Boehringer Ingelheim, Boston Scientific, The Bristol Myers Squibb and Pfizer Alliance, Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company, Gedeon Richter Plc., Menarini Int. Op., UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, Service de Pharmacologie médicale [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Cardiologie [CHU Pitié-Salpêtrière], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-CHU Trousseau [APHP], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and CHU Toulouse [Toulouse]
- Subjects
Adult ,Male ,Acute coronary syndrome ,medicine.medical_specialty ,medicine.drug_class ,Hemorrhage ,Outcomes ,030204 cardiovascular system & hematology ,Lower risk ,Risk Assessment ,[SHS]Humanities and Social Sciences ,03 medical and health sciences ,0302 clinical medicine ,Fibrinolytic Agents ,Risk Factors ,Physiology (medical) ,Internal medicine ,Cause of Death ,Antithrombotic ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Registries ,Practice Patterns, Physicians' ,Stroke ,Aged ,EORP-AF registry ,Aged, 80 and over ,Antithrombotic therapy ,business.industry ,Proportional hazards model ,Atrial fibrillation ,Vitamin K antagonist ,Middle Aged ,medicine.disease ,Observational registries ,Europe ,Female ,Cardiology and Cardiovascular Medicine ,business ,Fibrinolytic agent ,Follow-Up Studies - Abstract
Aims In recent years, stroke prevention in patients with atrial fibrillation (AF) has radically changed, with increasing use of non-vitamin K antagonist oral anticoagulants (NOACs). Contemporary European data on AF thromboprophylaxis are needed. Methods and results We report 1-year follow-up data from the EURObservational Research Programme in Atrial Fibrillation (EORP-AF) General Long-Term Registry. Outcomes were assessed according to antithrombotic therapy. At 1-year follow-up, 9663 (88.0%) patients had available data for analysis: 586 (6.1%) were not treated with any antithrombotic; 681 (7.0%) with antiplatelets only; 4066 (42.1%) with vitamin K antagonist (VKA) only; 3167 (32.8%) with NOACs only; and 1163 (12.0%) with antiplatelet and oral anticoagulant. At 1-year follow-up, there was a low rate of stroke (0.7%) and any thromboembolic event (TE) (1.2%), while haemorrhagic events occurred in 222 patients (2.3%). Cardiovascular (CV) death and all-cause death occurred in 3.9% and 5.2% of patients, respectively. Cumulative survival for all the three main outcomes considered was highest amongst patients treated only with NOACs (P Conclusion The 1-year follow-up of EORP-AF General Long-Term Registry reported a low occurrence of thromboembolic and haemorrhagic events, although mortality was high. Both VKA and NOACs were associated with a lower risk of all main adverse outcomes. All treatments were associated with a lower risk for CV death and all-cause death.
- Published
- 2019
21. GROUND BASED 3D MODELLING (PHOTOGRAMMETRY AND TLS) - SURVEY, DOCUMENTATION AND STRUCTURAL ASSESSMENT OF XX CENTURY CULTURAL HERITAGE IN INDIA – A CASE STUDY OF THE MASONRY VAULTS IN DEHRADUN
- Author
-
Tucci, G., Rihal, S., Betti, M., Conti, A., Fiorini, L., Kovacevic, V. C., and Bartoli, G.
- Subjects
Masonry vaults, Structural assessment, C.G. Blomfield, FEM, Educational, Capacity Building Initiative, TLS - Published
- 2019
22. Physical forcing and physical/biochemical variability of the Mediterranean Sea: a review of unresolved issues and directions for future research
- Author
-
Malanotte-Rizzoli, P., Artale, V., Borzelli-Eusebi, G.L., Brenner, S., Civitarese, G., Crise, A., Font, J., Gacic, M., Kress, N. (Nurit), Marullo, S., Ozsoy, E., Ribera d'Alcalà, M., Roether, W., Schroeder, K. (Katrin), Sofianos, S., Tanhua, T. (Toste), Theocharis, A. (Alexandre), Álvarez, M. (Marta), Ashkenazy, Y., Bergamasco, A., Cardin, V. (Vanessa), Carniel, S., D'Ortenzio, F., García-Ladona, E., García-Lafuente, J.M., Gogou, A. (Alexandra), Gregoire, M., Hainbucher, D., Kontoyiannis, H., Kovacevic, V., Kraskapoulou, E., Krokos, G., Incarbona, A., Mazzocchi, M.G. (Maria Grazia), Orlic, M., Pascual, A., Poulain, P.M. (Pierre-Marie), Rubino, A., Siokou-Frangou, I. (Ioanna), Souvermezoglou, E., Sprovieri, M., Taupier-Letage, I. (Isabelle), Tintoré, J. (Joaquim), Triantafyllou, G. (George), Malanotte-Rizzoli, P, Artale, V, Borzelli-Eusebi, GL, Brenner, S, Civitarese, G, Crise, A, Font, J, Gacic, M, Kress, N, Marullo, S, Ozsoy, E, Ribera d'Alcalà, M, Roether, W, Schroeder, K, Sofianos, S, Tanhua, T, Theocharis, A, Alvarez, M, Ashkenazy, Y, Bergamasco, A, Cardin, V, Carniel, S, D'Ortenzio, F, Garcia-Ladona, E, Garcia-Lafuente, JM, Gogou, A, Gregoire, M, Hainbucher, D, Kontoyannis, H, Kovacevic, V, Krasakapoulou, E, Krokos, G, Incarbona, A, Mazzocchi, MG, Orlic,M, Pascual, A, Poulain, PM, Rubino, A, Siokou-Frangou, J, Souvermezoglou, E, Sprovieri, M, Tintorè, J, Triantafyllou, G, Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences, Rizzoli, Paola M., Laboratoire d'océanographie de Villefranche (LOV), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Marullo, S., Artale, V., Observatoire océanologique de Villefranche-sur-mer (OOVM), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
0106 biological sciences ,Mediterranean climate ,010504 meteorology & atmospheric sciences ,Settore GEO/12 - Oceanografia e Fisica dell'Atmosfera ,Wind stress ,Review ,Physical oceanography ,Oceanography ,01 natural sciences ,Mediterranean sea ,physical forcing ,variability ,Mediterranean ,future research ,Mediterranean Sea ,14. Life underwater ,lcsh:Environmental sciences ,0105 earth and related environmental sciences ,[SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere ,lcsh:GE1-350 ,Forcing (recursion theory) ,business.industry ,010604 marine biology & hydrobiology ,Environmental resource management ,Property distribution ,lcsh:Geography. Anthropology. Recreation ,Object (philosophy) ,Geography ,lcsh:G ,13. Climate action ,Internal variability ,business - Abstract
Malanotte-Rizzoli, Paola ... et. al.-- 76 pages, The importance of the Mediterranean Sea for the world ocean has long been recognized. First, the Mediterranean sea has a profound impact on the Atlantic ocean circulation and, consequently, on the global thermohaline conveyor belt. Maps of the 5 Mediterranean salty water tongue exiting from the Gibraltar strait at intermediate depths and spreading throughout the Atlantic interior are well known since the 1950s. Through direct pathways to the Atlantic polar regions or through indirect mixing processes, the salty Mediterranean water preconditions the deep convection cells of the polar Atlantic. There the North Atlantic Deep Water is formed which successively spreads throughout 10 the world ocean constituting the core of the global thermohaline circulation. Even more importantly, the Mediterranean Sea is a laboratory basin for the investigation of processes of global importance, being much more amenable to observational surveys because of its location in mid-latitude and its dimensions. Both the western and eastern basins in fact possess closed thermohaline circulations analogous to the 15 global conveyor belt. A unique upper layer open thermohaline cell connects the eastern to the western basin and, successively, to the north Atlantic through the Gibraltar strait. In it, the Atlantic water entering into Gibraltar in the surface layer, after travelling to the easternmost Levantine basin, is transformed into one of the saltiest water masses through air–sea heat and moisture fluxes. This is the salty water which, crossing the 20 entire basin in the opposite direction below the surface Atlantic water, finally exits from the Gibraltar strait at mid-depths. Both the western and eastern basins are endowed with deep/intermediate convection cells analogous to the polar Atlantic deep convection cells or to the intermediate mode water ones. Deep and intermediate water masses are therefore formed in differ25 ent sites of the entire basin. Because of their easily accessible locations, these convection cells are much more amenable to direct observational surveys and mooring arrays
- Published
- 2014
23. Mapping and assessment of ecosystems and their services: An analytical framework for ecosystem condition: Discussion paper – Final
- Author
-
Maes, J., Teller, A., Erhard, M., Grizzetti, B., Barredo, J.I., Paracchini, M.L., Somma, F., Orgiazzi, A., Jones, A., Zulian, G., Vallecilo, S., Petersen, J.-E., Marquardt, D., Kovacevic, V., Abdul Malak, D., Marin, A.I., Czúcz, B., Mauri, A., Loffler, P., Bastrup-Birk, A., Biala, K., Christiansen, T., and Werner, B.
- Published
- 2018
24. GROUND BASED 3D MODELLING (PHOTOGRAMMETRY AND TLS) - SURVEY, DOCUMENTATION AND STRUCTURAL ASSESSMENT OF XX CENTURY CULTURAL HERITAGE IN INDIA – A CASE STUDY OF THE MASONRY VAULTS IN DEHRADUN
- Author
-
Tucci, G., primary, Rihal, S., additional, Betti, M., additional, Conti, A., additional, Fiorini, L., additional, Kovacevic, V. C., additional, and Bartoli, G., additional
- Published
- 2019
- Full Text
- View/download PDF
25. Electric field measurements in atmospheric pressure plasmas
- Author
-
Ana Sobota, Elmar Slikboer, Yen Nhi Nguyen, Marlous Hofmans, Sretenović, G., Kovacevic, V. V., Krstic, I. B., Obrusnik, A., Olivier Guaitella, Garcia-Caurel, E., Elementary Processes in Gas Discharges, Plasma & Materials Processing, and Atmospheric pressure non-thermal plasmas and their interaction with substrates
- Subjects
Physics::Plasma Physics - Abstract
Low temperature plasmas at atmospheric pressure offers possibilities that were not accessible to plasma-based technologies for a long time, such as usage on materials sensitive to high temperatures, (bio)materials that are not resistant to vacuuming or even fully drying, (bio)targets that are sensitive to significant current transfer. In addition to the simplicity with which the plasma sources can be built and the ease with which they can be operated, lot temperature plasmas have become very popular in the recent years. A great number of scientific publications has followed this rise in interest for atmospheric pressure plasmas, covering different geometries of mostly dielectric barrier discharges (DBDs), used with or without gas flow and a wide range of excitation frequencies from Hz to MHz. Most commonly reports address the discharge dynamics, densities of heavy species, at times gas temperature measurements, imaging of flow fields and rarely electron densities and electric field but very few on electric field measurements. This paper will give an overview of the recent work in the electric field measurements in atmospheric pressure plasma jets that operate in the ’bullet mode’. A Helium jet with flow rates up to 2 SLM, in a low-power mode (up to 1 W dissipated in the discharge). The jet is run in the bullet mode where one plasma bullet is emitted per voltage period. The results fill focus on the comparison between the jets driven by 30 kHz sine voltage and jets driven by short high voltage pulses. Two measurement methods have been used that allow for comparison between the electric field in the gas phase and on the treated targets, which vary from dielectrics to liquids.
- Published
- 2017
26. P1038Evaluation of atrial conduction time in relation to p wave dispersion in patients with different degree of hypertension arterialis with no history of paroxysmal atrial fibrillation
- Author
-
Djikic, D., primary, Mujovic, N., additional, Dejanovic, B., additional, Kocijancic, A., additional, Jankovic, N., additional, Marinkovic, M., additional, Kovacevic, V., additional, Orbovic, B., additional, Lazic, S., additional, and Simic, D., additional
- Published
- 2017
- Full Text
- View/download PDF
27. P1789Predictive value of heart rate variabillity parameters for atrial fibrillation recurrence after radiofrequency ablation for paroxysmal atrial fibrillation
- Author
-
Marinkovic, M., primary, Markovic, N., additional, Kovacevic, V., additional, Kocijancic, A., additional, Djikic, D., additional, Petrovic, I., additional, Orbovic, B., additional, Potpara, T., additional, Simic, D., additional, Stankovic, G., additional, and Mujovic, N., additional
- Published
- 2017
- Full Text
- View/download PDF
28. The SAMe-TT2R2 score and quality of anticoagulation in atrial fibrillation:a simple aid to decision-making on who is suitable (or not) for vitamin K antagonists
- Author
-
Ding, Wern Yew, Potpara, Tatjana, Blomström‐lundqvist, Carina, Boriani, Giuseppe, Marin, Francisco, Fauchier, Laurent, Lip, Gregory, Lip, G.Y.H., Tavazzi, L., Maggioni, A., Dan, G‐a., Nabauer, M., Kalarus, Z., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K.A, Erglis, A., Poposka, L., Burg, M., Crijns, H., Erküner, Ö., Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., Husseini, Z. El, Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., Genechten, G., Heidbuchel, H., Boussy, T., Coninck, M., Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., Hauwaert, B., Kuppens, C., Faes, D., Lier, D., Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska‐georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois‐jacquey, C., Kassim, H., Marijon, E., Le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden‐lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., Le Bidan, M., Pavin, D., Le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer‐bouchard, C., da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler‐schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., Di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V.L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum‐bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., Groot, J., Neefs, J., den Berg, N., Piersma, F., Wilde, A., Hagens, V., Es, J., Opstal, J., Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., Doorn, W., Szili‐torok, T., Bhagwandien, R., Janse, P., Muskens, A., Eck, M., Gevers, R., Der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch‐fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik‐sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska‐filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor‐broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca‐michta, I., Wozakowska‐kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc‐dyl, E., Miarka, J., Pasieka, M., Ziemińska‐łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska‐kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik‐lydka, A., Leopold‐jadczyk, A., Jedrzejczyk‐patej, E., Koziel, M., Mazurek, M., Krzemien‐wolska, K., Starosta, P., Nowalany‐kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu‐andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina‐ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic‐kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic‐tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic‐kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric‐cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic‐tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Mijatovic, A., Tanasic, D., Radakovic, G., Peranovic, J., Panic‐jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García‐bolao, I., Bertomeu Gonzalez, V., Otero‐raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil‐baron, P., Koç, M., Onrat, E., Dural, I., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U.O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., Mcmahon, S., Mcdonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., Mcskeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., Mckie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., Mckinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., Mckenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O’donohoe, L., Mozid, A., Dymond, H., Lloyd‐jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt‐kerby, T., Garnier, Sophie, Hengstenberg, Christian, Lamblin, Nicolas, Dubourg, Olivier, de Groote, Pascal, Trochu, Jean-Noël, Arbustini, Eloisa, Esslinger, Ulrike, Barton, Paul, Meder, Benjamin, Katus, Hugo, Frese, Karen, Komajda, Michel, Cook, Stuart, Isnard, Richard, Tiret, Laurence, Villard, Eric, Charron, Philippe, Angoulvant, D., University of Belgrade [Belgrade], Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Océan du Large et Variabilité Climatique (OLVAC), Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), University of Liverpool, Aalborg University [Denmark] (AAU), Maria Cecilia Hospital [Cotignola], Valorex SAS, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Department of Internal Medicine II, Division of Respirology, University of Regensburg, Regensburg, Germany, Universität Regensburg (UR), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Ambroise Paré [AP-HP], Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), IRCCS - Pavia, Heidelberg University Hospital [Heidelberg], Université Pierre et Marie Curie - Paris 6 (UPMC), Robert Steiner MRI Unit, Imperial College London, Université de Montréal (UdeM), CHU Tenon [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
Male ,medicine.medical_specialty ,Vitamin K ,MEDLINE ,Vitamin k ,Poor quality ,Decision Support Techniques ,[SHS]Humanities and Social Sciences ,Thromboembolism ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,In patient ,Blood Coagulation ,Stroke ,ComputingMilieux_MISCELLANEOUS ,Framingham Risk Score ,business.industry ,Anticoagulants ,Atrial fibrillation ,medicine.disease ,Surgery ,Cohort ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
This editorial refers to ‘Evaluation of SAMe-TT2R2 risk score for predicting the quality of anticoagulation control in a real-world cohort of patients with non-valvular atrial fibrillation on vitamin-K antagonists’ by M. R.R.-Y. Abumuaileq et al. , doi:10.1093/europace/euu353. Maintaining the therapeutic range in patients treated with vitamin K antagonists (VKAs) had always been challenging whilst the potential consequences of deviating from the optimal average time in therapeutic range(TTR) are deleterious in patients with atrial fibrillation (AF), given the risk for thromboembolic and bleeding events.1,2 Various clinical decision-making tools have been developed to help decision-making in the management of AF patients. In 2013, a new score—with the acronym SAMe-TT2R2—was proposed to help identify those patients who were likely to have a propensity to poor INR control (as reflected by average time in the therapeutic range [TTR] 2).3 This score was derived from a trial cohort and thus independent validation in ‘real-world’ AF cohorts would be needed. In the current issue of EP-Europace , Abumaileq et al. 4 performed a retrospective analysis of a cohort of outpatients with non-valvular AF and found that SAMe-TT2R2 could indeed represented a useful clinical tool to identify a poor quality of anticoagulation control with VKAs. The predictive ability of SAMe-TT2R2 was acceptable for identifying low TTR and improved when integrated with other clinical characteristics. A strong relationship …
- Published
- 2015
29. Physical forcing and physical/biochemical variability of the Mediterranean Sea:A review of unresolved issues and directions of future research
- Author
-
Malanotte Rizzoli, P, Artale, V, Borzelli Eusebi, GL, Brenner, S, Civitarese, G, Crise, A, Font, J, Gacic, M, Kress, N, Marullo, S, Ozsoy, E, Ribera d'Alcalà, M, Roether, W, Schroeder, K, Sofianos, S, Tanhua, T, Theocharis, A, Alvarez, M, Ashkenazy, Y, Bergamasco, A, Cardin, V, Carniel, S, D'Ortenzio, F, Garcia Ladona, E, Garcia Lafuente, JM, Gogou, A, Gregoire, M, Hainbucher, D, Kontoyannis, H, Kovacevic, V, Krasakapoulou, E, Krokos, G, Mazzocchi, MG, Orlic,M, Pascual, A, Poulain, PM, Rubino, A, Siokou Frangou, J, Souvermezoglou, E, Sprovieri, M, Taupier Letage, I, Tintorè, J, Triantafyllou, G., INCARBONA, Alessandro, Malanotte-Rizzoli, P, Artale, V, Borzelli-Eusebi, GL, Brenner, S, Civitarese, G, Crise, A, Font, J, Gacic, M, Kress, N, Marullo, S, Ozsoy, E, Ribera d'Alcalà, M, Roether, W, Schroeder, K, Sofianos, S, Tanhua, T, Theocharis, A, Alvarez, M, Ashkenazy, Y, Bergamasco, A, Cardin, V, Carniel, S, D'Ortenzio, F, Garcia-Ladona, E, Garcia-Lafuente, JM, Gogou, A, Gregoire, M, Hainbucher, D, Kontoyannis, H, Kovacevic, V, Krasakapoulou, E, Krokos, G, Incarbona, A, Mazzocchi, MG, Orlic,M, Pascual, A, Poulain, PM, Rubino, A, Siokou-Frangou, J, Souvermezoglou, E, Sprovieri, M, Taupier-Letage, I, Tintorè, J, and Triantafyllou, G
- Subjects
Oceanography, Paleoceanography, Mediterranean - Published
- 2012
30. Water flow in the inlets of the Grado-Marano Lagoon system, Northern Adriatic Sea
- Author
-
Mancero Mosquera I., Arena F., Kovacevic V., Villalta R., Lipizer M., Triches A., FONTOLAN, GIORGIO, PILLON, SIMONE, BEZZI, ANNELORE, FIST, Mancero Mosquera, I., Arena, F., Kovacevic, V., Villalta, R., Lipizer, M., Triches, A., Fontolan, Giorgio, Pillon, Simone, and Bezzi, Annelore
- Subjects
inlets ,inlet ,water flow ,tidal channel ,lagoon - Published
- 2011
31. Physical forcing and physical/biochemical variability of the Mediterranean Sea: A review of unresolved issues and directions for future research
- Author
-
Malanotte-Rizzoli, P. Artale, V. Borzelli-Eusebi, G.L. Brenner, S. Crise, A. Gacic, M. Kress, N. Marullo, S. Ribera D'Alcalà, M. Sofianos, S. Tanhua, T. Theocharis, A. Alvarez, M. Ashkenazy, Y. Bergamasco, A. Cardin, V. Carniel, S. Civitarese, G. D'Ortenzio, F. Font, J. Garcia-Ladona, E. Garcia-Lafuente, J.M. Gogou, A. Gregoire, M. Hainbucher, D. Kontoyannis, H. Kovacevic, V. Kraskapoulou, E. Kroskos, G. Incarbona, A. Mazzocchi, M.G. Orlic, M. Ozsoy, E. Pascual, A. Poulain, P.-M. Roether, W. Rubino, A. Schroeder, K. Siokou-Frangou, J. Souvermezoglou, E. Sprovieri, M. Tintoré, J. Triantafyllou, G.
- Abstract
This paper is the outcome of a workshop held in Rome in November 2011 on the occasion of the 25th anniversary of the POEM (Physical Oceanography of the Eastern Mediterranean) program. In the workshop discussions, a number of unresolved issues were identified for the physical and biogeochemical properties of the Mediterranean Sea as a whole, i.e., comprising the Western and Eastern sub-basins. Over the successive two years, the related ideas were discussed among the group of scientists who participated in the workshop and who have contributed to the writing of this paper. Three major topics were identified, each of them being the object of a section divided into a number of different sub-sections, each addressing a specific physical, chemical or biological issue: 1. Assessment of basin-wide physical/biochemical properties, of their variability and interactions. 2. Relative importance of external forcing functions (wind stress, heat/moisture fluxes, forcing through straits) vs. internal variability. 3. Shelf/deep sea interactions and exchanges of physical/biogeochemical properties and how they affect the sub-basin circulation and property distribution. Furthermore, a number of unresolved scientific/methodological issues were also identified and are reported in each sub-section after a short discussion of the present knowledge. They represent the collegial consensus of the scientists contributing to the paper. Naturally, the unresolved issues presented here constitute the choice of the authors and therefore they may not be exhaustive and/or complete. The overall goal is to stimulate a broader interdisciplinary discussion among the scientists of the Mediterranean oceanographic community, leading to enhanced collaborative efforts and exciting future discoveries. © Author(s) 2014.
- Published
- 2014
32. Crustal structure of the carpathian-pannonian region from ambient noise tomography
- Author
-
Ren, Y, Stuart, G, Houseman, G, Grecu, B, Hegedüs, E, Dando, B, Lorinczi, P, Gogus, O, Kovács, A, Török, I, László, I, Csabafi, R, Ionescu, C, Radulian, M, Raileanu, V, Tataru, D, Zaharia, B, Borleanu, F, Neagoe, C, Gainariu, G, Rau, D, Radovanovic, S, Kovacevic, V, Valcic, D, Petrovic-Cacic, S, Krunic, G, Brisbourne, A, Hawthorn, D, and Lane, V
- Abstract
We use ambient noise tomography to investigate the crust and uppermost mantle structure beneath the Carpathian-Pannonian region of Central Europe. Over 7500 Rayleigh wave empirical Green's functions are derived from interstation cross-correlations of vertical component ambient seismic noise recordings (2005-2011) using a temporary network of 54 stations deployed during the South Carpathian Project (2009-2011), 56 temporary stations deployed in the Carpathian Basins Project (2005-2007) and 100 permanent and regional broad-band stations. Rayleigh wave group velocity dispersion curves (4-40 s) are determined using the multiple-filter analysis technique. Group velocity maps are computed on a grid of 0.2° × 0.2° from a non-linear 2-D tomographic inversion using the subspace method. We then inverted the group velocity maps for the 3-D shear wave velocity structure of the crust and uppermost mantle beneath the region. Our shear wave velocity model provides a uniquely complete and relatively high-resolution view of the crustal structure in the Carpathian-Pannonian region, which in general is validated by comparison with previous studies using other methods to probe the crustal structure. At shallow depths (30 km are relatively fast, presumably related to shallowing of the Moho consequent on the extensional history of the Pannonian region.
- Published
- 2013
33. Carbon cycle variability in the northern Adriatic ecosystem: a re-analysis of historical data
- Author
-
Fonda S., Ravaioli M. (1), Kovacevic V., Cardin V., Cozzi S. (2), Giani M., Cataletto B., Socal G. (3), Saggiomo V., A. Russo, F. Crisciani, F. Spagnoli, A. Boldrin, A. Schirone, E. Paschini, R. Danovaro, B. Manca, R. Del fanti, and A. Pugnetti
- Subjects
northern Adriatic Sea ,carbon cycle ,primary production ,northern Adriatic ,biological pump ,physical pump - Abstract
The northern Adriatic has been recognized for many years as a region of high marine production at several trophic levels from phytoplankton to fish. The rivers draining into the northern Adriatic are the major sources of external nutrient input, especially during stratified periods. The water mass exchange between the northern region and the remainder of the essentially oligotrophic Adriatic has a great influence on the productivity and standing crops of different sub-areas. A terrigenous supply of nutrients all along the western coast via run-off influences the productivity of a relatively narrow coastal belt, and consequently the biomasses and production rates are spatially very variable. In shallow turbulent environments, like the northern Adriatic, where increased nutrient availability is episodic, the microbial or the grazing food web can alternately dominate in the carbon flow over short time periods. In spring, as a result of episodic nutrient enrichment of the euphotic zone and insufficient grazing, as a controlling factor of their population size, large-sized phytoplankton blooms occur that consequently determine a major export to the bottom via sedimentation. On the opposite, microbial food web is typical of low energy environment, mostly based on regeneration processes. As a consequence, the final fate of photosynthesised carbon can strongly change over time in the same environment as a function of the planktonic food web structures. In the framework of VECTOR project ("VulnErabilità delle Coste e degli ecosistemi marini italiani ai cambiamenti climaTici e loro ruolO nei cicli del caRbonio mediterraneo") a re-analisys of the entire available data set of parameters relevant in driving C fluxes and export rates has been planned to provide conceptual models and appropriate parametrizations to modelers, with the aim to hindcast and forecast ecosystem scenarios at the basin scale.
- Published
- 2007
34. Vorticity Patterns Offshore of the Venetian Lagoon from HF Radar Observations
- Author
-
Paduan, J.D., Gacic, M., Kovacevic, V., Mosquera, I. Mancero, Mazzoldi, A., and Oceanography
- Abstract
A network of high frequency (HF) radar systems was used to produce maps of surface velocity offshore of the Malamocco inlet during the 12-month period from November 2001 through October 2002. Inspection of the sub-tidal residual flow fields revealed frequent occurrences of small-scale (~10 km) eddy structures both north and south of the inlet. In addition, several monthly averaged velocity maps indicate the presence of a persistent meander in the mean current patterns. A more objective technique, based on vorticity, was developed to search the data set for the presence of eddies near the inlet and to separate those features from the larger-scale meander pattern. The vorticity at scales of 5-10 km was computed each hour using the low-passfiltered data set and year-long vorticity statistics were investigated at selected locations surrounding the inlet. The vorticity histograms and temporal variability changed significantly as a function of location relative to the Malamocco inlet. Both north and south of the inlet, the mean vorticity was weakly negative reflecting the larger-scale meander pattern whose crest is aligned, approximately, with the inlet. However, the range of vorticity north of the inlet was much greater than it was south of the inlet. A minor peak (or shoulder) in the year-long histogram of vorticity north of the inlet highlighted frequent occurrences of strong (~ 5 × 10-5 s-1) positive vorticity events in that area. A similar statistical behaviour was not seen south of the inlet. This observation was used to define a conditional sampling criteria that lead to a map of the typical flow field associated with strong eddy events. The vorticity time series were also used to investigate the relationship of eddy events to external forcing parameters. Strong winds, for instance, acted to destroy vorticity in the surface current field since they lead to a strong but horizontally uniform response in the surface currents. The roles of sea level variability and offshore current velocity were also investigated.
- Published
- 2003
35. Nutrients and Particulate Matter dynamics and exchanges in the Otranto Strait
- Author
-
Civitarese G., Gacic M., Vetrano A., Kovacevic V., Boldrin A., Bregant D., Cozzi S., De Lazzari A., Krasakopoulou E., Rabitti S., and Souvermezoglou E.
- Abstract
A series of seasonal cruises and Eulerian current measurements in the Otranto Strait were carried out to study the biogeochemical characteristics of the strait and to estimate the exchange of water, dissolved and particulate matter between the Adriatic and the Ionian Sea. From the biogeochemical distributions obtained, the role for the Adriatic Sea in supporting the N:P ratio anomaly of the Mediterranean is hypothesized. Examining the bottom oxygen distribution, the deep ventilation of the Eastern Mediterranean seems to follow a more complex pathway than previously hypothesized Fluxes computation shows a net outflow through the strait for nitrate, phosphate and silicate, while a slight net inflow was obtained for POC and PN.
- Published
- 1999
36. Predictors of significant left main/ostial left anterior descending coronary artery stenosis in patients with exercise induced ST segment elevation in lead aVR
- Author
-
Petrovic, M. T., primary, Giga, V., additional, Dobric, M., additional, Kovacevic, V., additional, Marinkovic, M., additional, Jovanovic, I., additional, Nedeljkovic, I., additional, Beleslin, B., additional, Djordjevic-Dikic, A., additional, and Stepanovic, J., additional
- Published
- 2013
- Full Text
- View/download PDF
37. Measles situation in Serbia in an era of measles elimination (2007-2009)
- Author
-
Nedeljkovic, Jasminka, primary, Rakic-Adrovic, S., additional, Lazic, B., additional, Kovacevic, V., additional, Loncarevic, G., additional, Kanazir, M., additional, Seguljev, Z., additional, Petrovic, V., additional, Milosevic, V., additional, Zakula, N., additional, Begovic, I., additional, Muller, C.P., additional, and Hübschen, J.M., additional
- Published
- 2013
- Full Text
- View/download PDF
38. EU‐sponsored effort improves monitoring of circulation variability in the Mediterranean
- Author
-
Manzella, G. M. R., primary, Cardin, V., additional, Cruzado, A., additional, Fusco, G., additional, Gacic, M., additional, Galli, C., additional, Gasparini, G. P., additional, Gervais, T., additional, Kovacevic, V., additional, Millot, C., additional, DeLa Villeon, L. Petit, additional, Spaggiari, G., additional, Tonani, M., additional, Tziavos, C., additional, Velasquez, Z., additional, Zervakis, Walne V., additional, and Zodiatis, G., additional
- Published
- 2001
- Full Text
- View/download PDF
39. Role of dense shelf water in the development of Antarctic submarine canyon morphology
- Author
-
Florence Colleoni, Daniela Accettella, Andrea Bergamasco, Sookwan Kim, Elisabetta Olivo, F. Zgur, Yanguang Liu, L. De Santis, Michele Rebesco, J. A. Gales, Vedrana Kovačević, Robert M. McKay, Ester Colizza, Cristian Florindo-Lopez, Gales, J., Rebesco, M., De Santis, L., Bergamasco, A., Colleoni, F., Kim, S., Accettella, D., Kovacevic, V., Liu, Y., Olivo, E., Colizza, E., Florindo-Lopez, C., Zgur, F., and Mckay, R.
- Subjects
Canyon ,geography ,geography.geographical_feature_category ,010504 meteorology & atmospheric sciences ,Meltwater ,Continental shelf ,Slope proce ,Submarine canyon ,010502 geochemistry & geophysics ,01 natural sciences ,Ice shelf ,Continental slope ,Slope process ,Submarine gully ,Oceanography ,Continental margin ,Circumpolar deep water ,Ice sheet ,Geology ,0105 earth and related environmental sciences ,Earth-Surface Processes - Abstract
Increased ocean heat supply to the Antarctic continental shelves is projected to cause accelerated ice sheet loss and contribute significantly to global sea-level rise over coming decades. Changes in temperature or salinity of dense shelf waters around Antarctica, resulting from increased glacial meltwater input, have the potential to significantly impact the location and structure of the global Meridional Overturning Circulation, with seabed irregularities such as submarine canyons, driving these flows toward the abyss. Submarine canyons also influence the location of intruding warm water currents by acting as preferential routes for rising Circumpolar Deep Water. These global changes have implications for large-scale effects to atmospheric and oceanic circulation. The ability for numerical modellers to predict these future behaviours is dependent upon our ability to understand both modern and past oceanic, sedimentological and glaciological processes. This knowledge allows ocean models to better predict the flux and pathways of Circumpolar Deep Water delivery to the shelf, and consequently to ice shelf cavities where melt is concentrated. Here we seek to understand how dense shelf water and other continental slope processes influence submarine canyon morphology by analysing newly collected geophysical and oceanographic data from a region of significant and prolonged dense shelf water export, the Hillary Canyon in the Ross Sea. We find that cascading flows of dense shelf water do not contribute to significant gully incision at the shelf edge during interglacial periods, however, are strong enough to prevent gully infilling and contribute to canyon-levee aggradation down-slope. We find buried paleo-gullies beneath gullies incising the modern seafloor. Paleo-gullies occur as single gullies and in complexes indicating that gully activity was continuous over multiple glacial cycles and formed an important role in the development of the shelf edge and upper slope. Glacial cycles likely drive large-scale shifts in canyon head processes with periods of intense seafloor erosion and significant gully incision likely occurring when ice grounded near to the shelf edge, during glacial and deglacial periods, when sediment-laden subglacial meltwater was released at the shelf edge. We put slope morphology observed at the Hillary Canyon head into global perspective to show that cascading flows of dense shelf water do not exert consistent patterns of erosion on high-latitude continental margins.
- Published
- 2021
40. Ricostruzioni paleoambientali e paleoclimatiche e Processi sedimentari post-LGM sul margine continentale del Mare di Barents Nord-Occidentale
- Author
-
R. G. Lucchi, D. Accettella, S. Aliani, BENSI, MANUEL, A. Caburlotto, A. Camerlenghi, K. Carbonara, C. Caricchi, M. Celussi, C. De Victor, GIORGETTI, GIORGIO, M. Giustiniani, V. Kovacevic, L. Langone, P. Macri’, G. Madrussani, R. Melis, K Mezgec, C. Morigi, M. E. Musco, M. Rebesco, G. Rossi, L. Rui, A. Sabbatini L. Sagnotti, U. Tinivella, G. Varagona, G. Villa, Lucchi, R. G., Accettella, D., Aliani, S., Bensi, Manuel, Caburlotto, A., Camerlenghi, A., Carbonara, K., Caricchi, C., Celussi, M., De Victor, C., Giorgetti, Giorgio, Giustiniani, M., Kovacevic, V., Langone, L., Macri’, P., Madrussani, G., Melis, R., Mezgec, K, Morigi, C., Musco, M. E., Rebesco, M., Rossi, G., Rui, L., Sagnotti, A. Sabbatini L., Tinivella, U., Varagona, G., and Villa, G.
- Subjects
Svalbard ,sedimentary processes ,contour currents ,Arctic ,palaeoenvironment ,Barents Sea ,LGM, MWP-1a ,palaeoceanography ,palaeoclimate ,MWP-1a ,LGM ,contour current - Abstract
Le finalità della ricerca nell’Artico di OGS in collaborazione con numerosi partners italiani e internazionali, riguarda la ricostruzione del registro sedimentario marino dei processi di deglaciazione dall'ultimo massimo glaciale fino ad oggi, l'interazione tra circolazione oceanica e sedimentazione nello stretto di Fram e sul margine occidentali delle Svalbard, e la distribuzione di idrati di metano nei sedimenti marini dell'intera zona Artica. Il lavoro di raccolta dati è stato effettuato sia attraverso spedizioni oceanografiche italiane con la R/V OGS-Explora (2008, 2013, 2015) sia attraverso altre piattaforme di ricerca internazionali (R/V Jan Mayen, 2001, 2009; R/V Hesperides, 2007; R/V Maria S. Merian, 2013; R/V G.O. Sars, 2014; R/V Polarstern, 2016) anche utilizzando strumentazione all’avanguardia come il sistema di perforazione automatizzato MeBo (Hanebuth et al., 2014), il Calypso piston corer per lunghi campionamenti (> 20 m, Lucchi et al., 2014) e sistemi di campionamento video-assistiti come il TV-Multi corer, e l’Ocean Floor Observatory System (Lucchi et al., 2016). La ricerca sedimentologica e paleoceanografica ha portato alla ricostruzione temporale dei processi sedimentari che hanno accompagnato l'ultimo ritiro della calotta glaciale delle Svalbard-Barents (Pedrosa et al., 2011, Sagnotti et al., 2012). Le modalità del ritiro dei flussi di ghiaccio (ice streams) hanno prodotto un forte impatto sul sistema deposizionale locale, creando aree di instabilità lungo la scarpata continentale (Lucchi et al., 2012; Rebesco et al., 2012; Llopart et al., 2014) e influenzando il ripristino e sviluppo della produttività primaria locale per la presenza di acque torbide di fusione che influenzarono le proprietà fisiche e composizionali delle masse d’acqua (Lucchi et al., 2013). Inoltre è stato identificato per la prima volta nell’Artico, il deposito sedimentario legato all’evento eccezionale di rilascio di acque di fusione degli ice streams denominato Meltwater Pulse 1a (Lucchi et al., 2015, Sagnotti et al., 2016) responsabile dell’innalzamento del livello eustatico di circa 20 m in soli 320 anni. I sediment drifts di Bellsund e Isfjorden osservati sul margine occidentale delle isole Svalbard, contengono un registro paleoceanografico continuo degli ultimi 3.5 M di anni, con accumulo sedimentario alimentato anche attraverso le acque dense (brine) prodotte sulla piattaforma continentale (Rebesco et al., 2013; 2014). La ricerca sugli idrati di metano in ambiente artico ha permesso la caratterizzazione in 3D di Vp, Vs e Q (attenuazione) su un campo di idrati del margine della Svalbard e la loro associazione con il sistema di circolazione di fluidi (Madrussani et al., 2009; Rossi et al., 2007; Carcione et al., 2005). Giustiniani et al. (2013) e Marín-Moreno et al. (2016) hanno prodotto un modello di distribuzione degli idrati di metano per tutto l'Oceano Artico con definizione della riserva metastabile di carbonio nell'Oceano Artico. Infine, i dati batimetrici raccolti da OGS sono stati inseriti nella versione 3.0 dell'International Bathymetric Chart of the Arctic Ocean (IBCAO) (Jokobsson et al., 2013).
- Published
- 2016
41. Physiological Response to the COVID-19 Vaccine: Insights From a Prospective, Randomized, Single-Blinded, Crossover Trial.
- Author
-
Markovic A, Kovacevic V, Brakenhoff TB, Veen D, Klaver P, Mitratza M, Downward GS, Grobbee DE, Cronin M, and Goodale BM
- Subjects
- Humans, Female, Male, Adult, Prospective Studies, Single-Blind Method, Netherlands, Respiratory Rate, Menstrual Cycle, SARS-CoV-2 immunology, Skin Temperature, Vaccination, Middle Aged, Young Adult, COVID-19 Vaccines administration & dosage, Heart Rate, COVID-19 prevention & control, Cross-Over Studies
- Abstract
Background: Rapid development and implementation of vaccines constituted a crucial step in containing the COVID-19 pandemic. A comprehensive understanding of physiological responses to these vaccines is important to build trust in medicine., Objective: This study aims to investigate temporal dynamics before and after COVID-19 vaccination in 4 physiological parameters as well as the duration of menstrual cycle phases., Methods: In a prospective trial, 17,825 adults in the Netherlands wore a medical device on their wrist for up to 9 months. The device recorded their physiological signals and synchronized with a complementary smartphone app. By means of multilevel quadratic regression, we examined changes in wearable-recorded breathing rate, wrist skin temperature, heart rate, heart rate variability, and objectively assessed the duration of menstrual cycle phases in menstruating participants to assess the effects of COVID-19 vaccination., Results: The recorded physiological signals demonstrated short-term increases in breathing rate and heart rate after COVID-19 vaccination followed by a prompt rebound to baseline levels likely reflecting biological mechanisms accompanying the immune response to vaccination. No sex differences were evident in the measured physiological responses. In menstruating participants, we found a 0.8% decrease in the duration of the menstrual phase following vaccination., Conclusions: The observed short-term changes suggest that COVID-19 vaccines are not associated with long-term biophysical issues. Taken together, our work provides valuable insights into continuous fluctuations of physiological responses to vaccination and highlights the importance of digital solutions in health care., International Registered Report Identifier (irrid): RR2-10.1186/s13063-021-05241-5., (©Andjela Markovic, Vladimir Kovacevic, Timo B Brakenhoff, Duco Veen, Paul Klaver, Marianna Mitratza, George S Downward, Diederick E Grobbee, Maureen Cronin, Brianna M Goodale, COVID-19 Remote Early Detection (COVID-RED) consortium. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 31.07.2024.)
- Published
- 2024
- Full Text
- View/download PDF
42. Footprint of sustained poleward warm water flow within East Antarctic submarine canyons.
- Author
-
Donda F, Rebesco M, Kovacevic V, Silvano A, Bensi M, De Santis L, Rosenthal Y, Torricella F, Baradello L, Gei D, Leventer A, Post A, Leitchenkov G, Noble T, Zgur F, Cova A, O'Brien P, and Romeo R
- Abstract
The intrusion of relatively warm water onto the continental shelf is widely recognized as a threat to Antarctic ice shelves and glaciers grounded below sea level, as enhanced ocean heat increases their basal melt. While the circulation of warm water has been documented on the East Antarctic continental shelf, the modes of warm water transport from the deep ocean onto the shelf are still uncertain. This makes predicting the future responses of major East Antarctic marine-grounded glaciers, such as Totten and Ninnis glaciers, particularly challenging. Here, we outline the key role of submarine canyons to convey southward flowing currents that transport warm Circumpolar Deep Water toward the East Antarctic shelf break, thus facilitating warm water intrusion on the continental shelf. Sediment drifts on the eastern flank of the canyons provide evidence for sustained southward-directed flows. These morpho-sedimentary features thus highlight areas potentially prone to enhanced ocean heat transport toward the continental shelf, with repercussions for past, present, and future glacial melting and consequent sea level rise., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
43. Prevalence of Risk Factors in Patients with Postprocedural Ischemic Lesions after Coiling of Very Small Intracranial Aneurysms.
- Author
-
Lukic S, Zornic N, Jovanovic N, Rasulic L, and Kovacevic V
- Abstract
Background: Very small intracranial aneurysms, generally considered to be those 3 mm in diameter or smaller, pose particular technical challenges for endovascular surgeons. For this reason, very small aneurysms have been excluded from many relevant studies. The aim of our research was to establish the risk factors for the occurrence of stroke complications after endovascular embolization of ruptured and unruptured small intracranial aneurysms. Methods: During the period of 2009-2023, our team performed endovascular embolizations of intracranial aneurysms in 1567 patients across four different centers within the territory of Serbia and Montenegro. Within the total number of patients mentioned, aneurysms of less than 4 mm were treated 185 times, with 119 ruptured and 66 unruptured. Results: In the group of 119 patients with ruptured small intracranial aneurysms, 19 (16%) patients had ischemia after the endovascular treatment, 6 (5%) patients had minor neurological deficits, while 13 (10.9%) patients had major neurological deficits, of which 6 (5%) patients died. In the group of 66 patients with unruptured small intracranial aneurysms, 7 (10.6%) patients had ischemia after the endovascular treatment, 5 (7.6%) patients had minor neurological deficits, and 2 (3.03%) had major neurological deficits. Multivariate binary logistic regression showed that the risk factors for the occurrence of ischemia were the patient's age, smoking and alcohol consumption. The type of endovascular treatment used also had a statistically significant effect on the development of ischemia. Conclusions: Understanding the influence of possible risk factors for the occurrence of ischemic insult after embolization of small intracranial aneurysms is of great importance. By recognizing them, periprocedural complications can be reduced to a minimum.
- Published
- 2024
- Full Text
- View/download PDF
44. Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study).
- Author
-
Grossmann K, Risch M, Markovic A, Aeschbacher S, Weideli OC, Velez L, Kovac M, Pereira F, Wohlwend N, Risch C, Hillmann D, Lung T, Renz H, Twerenbold R, Rothenbühler M, Leibovitz D, Kovacevic V, Klaver P, Brakenhoff TB, Franks B, Mitratza M, Downward GS, Dowling A, Montes S, Veen D, Grobbee DE, Cronin M, Conen D, Goodale BM, and Risch L
- Subjects
- Male, Humans, Female, Adult, Retrospective Studies, SARS-CoV-2, Algorithms, Biophysics, COVID-19 diagnosis
- Abstract
Considering sex as a biological variable in modern digital health solutions, we investigated sex-specific differences in the trajectory of four physiological parameters across a COVID-19 infection. A wearable medical device measured breathing rate, heart rate, heart rate variability, and wrist skin temperature in 1163 participants (mean age = 44.1 years, standard deviation [SD] = 5.6; 667 [57%] females). Participants reported daily symptoms and confounders in a complementary app. A machine learning algorithm retrospectively ingested daily biophysical parameters to detect COVID-19 infections. COVID-19 serology samples were collected from all participants at baseline and follow-up. We analysed potential sex-specific differences in physiology and antibody titres using multilevel modelling and t-tests. Over 1.5 million hours of physiological data were recorded. During the symptomatic period of infection, men demonstrated larger increases in skin temperature, breathing rate, and heart rate as well as larger decreases in heart rate variability than women. The COVID-19 infection detection algorithm performed similarly well for men and women. Our study belongs to the first research to provide evidence for differential physiological responses to COVID-19 between females and males, highlighting the potential of wearable technology to inform future precision medicine approaches., Competing Interests: The authors have read the journal’s policy and have the following competing interests: Lorenz Risch, and Martin Risch are key shareholders of the Dr Risch Medical Laboratory. David Conen has received consulting fees from Roche Diagnostics, outside of the current work. Andjela Markovic, Vladimir Kovacevic, Martina Rothenbühler, Brianna Goodale and Maureen Cronin are past employees of Ava AG. Brianna Goodale and Timo Brakenhoff are current employees of Julius Clinical BV. Billy Franks is a former employee of Julius Clinical BV and now an employee of Haleon. Paul Klaver and Duco Veen are former employees of Julius Clinical BV. Marianna Mitratza is a current employee of P95 CVBA. There are no patents, products in development or marketed products associated with this research to declare. These competing interests do not alter our adherence to PLOS ONE policies on sharing data and materials., (Copyright: © 2024 Grossmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
- Full Text
- View/download PDF
45. Galectin-3's Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential.
- Author
-
Dimitrijevic Stojanovic M, Stojanovic B, Radosavljevic I, Kovacevic V, Jovanovic I, Stojanovic BS, Prodanovic N, Stankovic V, Jocic M, and Jovanovic M
- Subjects
- Humans, Galectin 3 genetics, Galectin 3 metabolism, Signal Transduction, Pancreatic Neoplasms, Pancreatic Neoplasms metabolism, Carcinoma, Pancreatic Ductal drug therapy, Carcinoma, Pancreatic Ductal metabolism
- Abstract
Galectin-3 (Gal-3) plays a multifaceted role in the development, progression, and prognosis of pancreatic ductal adenocarcinoma (PDAC). This review offers a comprehensive examination of its expression in PDAC, its interaction with various immune cells, signaling pathways, effects on apoptosis, and therapeutic resistance. Additionally, the prognostic significance of serum levels of Gal-3 is discussed, providing insights into its potential utilization as a biomarker. Critical analysis is also extended to the inhibitors of Gal-3 and their potential therapeutic applications in PDAC, offering new avenues for targeted treatments. The intricate nature of Gal-3's role in PDAC reveals a complex landscape that demands a nuanced understanding for potential therapeutic interventions and monitoring.
- Published
- 2023
- Full Text
- View/download PDF
46. Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach.
- Author
-
Petrosyan V, Dobrolecki LE, Thistlethwaite L, Lewis AN, Sallas C, Srinivasan RR, Lei JT, Kovacevic V, Obradovic P, Ellis MJ, Osborne CK, Rimawi MF, Pavlick A, Shafaee MN, Dowst H, Jain A, Saltzman AB, Malovannaya A, Marangoni E, Welm AL, Welm BE, Li S, Wulf GM, Sonzogni O, Huang C, Vasaikar S, Hilsenbeck SG, Zhang B, Milosavljevic A, and Lewis MT
- Abstract
Although systemic chemotherapy remains the standard of care for TNBC, even combination chemotherapy is often ineffective. The identification of biomarkers for differential chemotherapy response would allow for the selection of responsive patients, thus maximizing efficacy and minimizing toxicities. Here, we leverage TNBC PDXs to identify biomarkers of response. To demonstrate their ability to function as a preclinical cohort, PDXs were characterized using DNA sequencing, transcriptomics, and proteomics to show consistency with clinical samples. We then developed a network-based approach (CTD/WGCNA) to identify biomarkers of response to carboplatin (MSI1, TMSB15A, ARHGDIB, GGT1, SV2A, SEC14L2, SERPINI1, ADAMTS20, DGKQ) and docetaxel (c, MAGED4, CERS1, ST8SIA2, KIF24, PARPBP). CTD/WGCNA multigene biomarkers are predictive in PDX datasets (RNAseq and Affymetrix) for both taxane- (docetaxel or paclitaxel) and platinum-based (carboplatin or cisplatin) response, thereby demonstrating cross-expression platform and cross-drug class robustness. These biomarkers were also predictive in clinical datasets, thus demonstrating translational potential., Competing Interests: M.T.L is a Founder of, and an uncompensated Limited Partner in, StemMed Ltd., and an uncompensated Manager in StemMed Holdings L.L.C., its General Partner. MTL is also a Founder of, and equity stake holder in, Tvardi Therapeutics Inc. L.E.D. is a compensated employee of StemMed Ltd. Selected BCM PDX models described herein are exclusively licensed to StemMed Ltd., resulting in tangible property royalties to M.T.L. and L.E.D. University of Utah may license the HCI PDX models described herein to for-profit companies, which may result in tangible property royalties to A.L.W. and B.E.W. Washington University has licensed selected PDX to Envigo, which results in tangible property royalties to S.L. He also received research funding from Pfizer, Takeda Oncology, and Zenopharm, independent of this project. S.L. has received license fees from Envigo. He received research funding from Pfizer, Takeda Oncology, and Zenopharm, outside of this project. O.S, is a compensated employee of, and equity stake holder in, Bluebird Bio. M.J.E. received consulting fees from Abbvie, Sermonix, Pfizer, AstraZeneca, Celgene, NanoString, Puma, Veracyte, Eli Lilly, and Novartis, and he is an equity stockholder and Board of Directors member of BioClassifier. M.J.E. is an inventor on a patent for the Breast Cancer PAM50-based assay, Prosigna, which is marketed by Veracyte. M.J.E. also receives royalties from Washington University in St Louis when the WHIM PDX lines are licensed to for-profit companies., (© 2022.)
- Published
- 2022
- Full Text
- View/download PDF
47. Sex-related differences in self-reported treatment burden in patients with atrial fibrillation.
- Author
-
Mihajlovic M, Simic J, Marinkovic M, Kovacevic V, Kocijancic A, Mujovic N, and Potpara TS
- Abstract
Background: Treatment burden (TB) is defined as the patient's workload of healthcare and its impact on patient functioning and wellbeing. High TB can lead to non-adherence, a higher risk of adverse outcomes and lower quality of life (QoL). We have previously reported a higher TB in patients with atrial fibrillation (AF) vs. those with other chronic conditions. In this analysis, we explored sex-related differences in self-reported TB in AF patients., Materials and Methods: A single-center, prospective study included consecutive patients with AF under drug treatment for at least 6 months before enrollment from April to June 2019. Patients were asked to voluntarily and anonymously answer the Treatment Burden Questionnaire (TBQ). All patients signed the written consent for participation., Results: Of 331 patients (mean age 65.4 ± 10.3 years, mean total AF history 6.41 ± 6.62 years), 127 (38.4%) were females. The mean TB was significantly higher in females compared to males (53.7 vs. 42.6 out of 170 points, p < 0.001), and females more frequently reported TB ≥ 59 points than males (37.8% vs. 20.6%, p = 0.001). In females, on multivariable analysis of the highest TB quartile (TB ≥ 59), non-vitamin K Antagonist Oral Anticoagulant (NOAC) use [Odds Ratio (OR) 0.319; 95% Confidence Interval (CI) 0.12-0.83, P = 0.019], while in males, catheter ablation and/or ECV of AF (OR 0.383; 95% CI 0.18-0.81, P = 0.012) were negatively associated with the highest TB quartile., Conclusion: Our study was the first to explore the sex-specific determinants of TB in AF patients. Females had significantly higher TB compared with males. Approximately 2 in 5 females and 1 in 5 males reported TB ≥ 59 points, previously shown to be an unacceptable burden of treatment for patients. Using a NOAC rather than vitamin K antagonist (VKA) in females and a rhythm control strategy in males could decrease TB to acceptable values., Competing Interests: TP served as a consultant for Bayer and Pfizer with no personal fees. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Mihajlovic, Simic, Marinkovic, Kovacevic, Kocijancic, Mujovic and Potpara.)
- Published
- 2022
- Full Text
- View/download PDF
48. Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective cohort study (COVI-GAPP).
- Author
-
Risch M, Grossmann K, Aeschbacher S, Weideli OC, Kovac M, Pereira F, Wohlwend N, Risch C, Hillmann D, Lung T, Renz H, Twerenbold R, Rothenbühler M, Leibovitz D, Kovacevic V, Markovic A, Klaver P, Brakenhoff TB, Franks B, Mitratza M, Downward GS, Dowling A, Montes S, Grobbee DE, Cronin M, Conen D, Goodale BM, and Risch L
- Subjects
- Adult, Cohort Studies, Humans, Middle Aged, Prospective Studies, SARS-CoV-2, COVID-19 diagnosis
- Abstract
Objectives: We investigated machinelearningbased identification of presymptomatic COVID-19 and detection of infection-related changes in physiology using a wearable device., Design: Interim analysis of a prospective cohort study., Setting, Participants and Interventions: Participants from a national cohort study in Liechtenstein were included. Nightly they wore the Ava-bracelet that measured respiratory rate (RR), heart rate (HR), HR variability (HRV), wrist-skin temperature (WST) and skin perfusion. SARS-CoV-2 infection was diagnosed by molecular and/or serological assays., Results: A total of 1.5 million hours of physiological data were recorded from 1163 participants (mean age 44±5.5 years). COVID-19 was confirmed in 127 participants of which, 66 (52%) had worn their device from baseline to symptom onset (SO) and were included in this analysis. Multi-level modelling revealed significant changes in five (RR, HR, HRV, HRV ratio and WST) device-measured physiological parameters during the incubation, presymptomatic, symptomatic and recovery periods of COVID-19 compared with baseline. The training set represented an 8-day long instance extracted from day 10 to day 2 before SO. The training set consisted of 40 days measurements from 66 participants. Based on a random split, the test set included 30% of participants and 70% were selected for the training set. The developed long short-term memory (LSTM) based recurrent neural network (RNN) algorithm had a recall (sensitivity) of 0.73 in the training set and 0.68 in the testing set when detecting COVID-19 up to 2 days prior to SO., Conclusion: Wearable sensor technology can enable COVID-19 detection during the presymptomatic period. Our proposed RNN algorithm identified 68% of COVID-19 positive participants 2 days prior to SO and will be further trained and validated in a randomised, single-blinded, two-period, two-sequence crossover trial. Trial registration number ISRCTN51255782; Pre-results., Competing Interests: Competing interests: LR, and MR are key shareholders of the Dr Risch Medical Laboratory. DC has received consulting fees from Roche Diagnostics, outside of the current work. MR, DL, VK, AM, MC, and BMG are employed by Ava AG. The other authors have no financial or personal conflicts of interest to declare., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
- Full Text
- View/download PDF
49. Transcatheter Aortic Valve Implantation: A Report on Serbia's First Systematic Program.
- Author
-
Boljevic D, Bojic M, Farkic M, Sagic D, Topic D, Kovacevic V, Lakcevic J, Veljkovic S, Dobric M, Hinic S, Ilijevski N, Nikolic M, Kaludjerovic A, Bunc M, and Nikolic A
- Abstract
Introduction: Severe aortic stenosis, a highly-common valve disease in the elderly, has a poor prognosis if left untreated. To address the concern of effective procedures for severe aortic stenosis, a systematic TAVI program was established at the Dedinje Cardiovascular Institute (Belgrade, Serbia)., Methods: Our cohort was composed of 56 patients (74±15 years old). The mean logistic EuroScore was 10.17%; the mean Society of Thoracic Surgeons score was 3.22%. One third of the patients were categorized as class III or IV of the New York Heart Association (NYHA). The valves selected for use were either self-expandable or balloon expandable (Evolut R, Medtronic; Acurate Neo, Boston Scientific and Myval, Meril). The choice of valve type was made by the Institute's Structural Heart Team, in accordance with the patient's native aortic valve, size and calcification of ilio-femoral vessels, as well as the need for alternative access. TAVI procedure was conducted according to current guidelines provided by the European Society of Cardiology., Results: The procedure success rate was 100%. Trans-femoral approach was achieved in 100% of patients; percutaneously in 87.5%, while a surgical cut was necessary in 12.5%. No patient showed moderate or severe aortic regurgitation after the procedure, although trace or mild regurgitation was recorded in 30.3%. Permanent pacemaker was implanted in one patient (1.78%), contrast induced acute kidney injury occured in one patient (1.78%), no stroke was recorded, and three pseudo-aneurysms which required surgical intervention occurred. Three patients required blood transfusions (5.33%). A 30-day all-cause mortality rate was 1.78%., Conclusion: The Dedinje Cardiovascular Institute spearheaded all efforts to establish a TAVI program in Serbia. Our initial TAVI results are promising, encouraging, and comparable with the results of previous large randomized trials. This initial experience opens the door for further development with a goal of our Institute to become a high-volume TAVI center., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Boljevic, Bojic, Farkic, Sagic, Topic, Kovacevic, Lakcevic, Veljkovic, Dobric, Hinic, Ilijevski, Nikolic, Kaludjerovic, Bunc and Nikolic.)
- Published
- 2022
- Full Text
- View/download PDF
50. Surgical Removal of The Mechanical Valve Leaflet Dislocated into The Pulmonary Vein.
- Author
-
Zdravkovic D, Zivkovic I, Kovacevic V, Milacic P, and Milicic M
- Subjects
- Humans, Mitral Valve surgery, Reoperation, Heart Valve Prosthesis adverse effects, Heart Valve Prosthesis Implantation methods, Pulmonary Veins diagnostic imaging, Pulmonary Veins surgery
- Abstract
Accidental detachment of mechanical valve leaflet during implantation is a rare and potentially serious complication. When the lost leaflet cannot be found by direct visualisation, additional diagnostic procedures are necessary to detect it. Computer tomography is the best detection method, but the patient needs reoperation. We presented a patient in whom the detached leaflet migrated and became trapped into the left inferior pulmonary vein. The computed tomography (CT) scan was used to reveal leaflets, and successful extirpation was performed in the second operation.
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.