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Your search keyword '"Koshino, Kenji"' showing total 11 results
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11 results on '"Koshino, Kenji"'

1. Usefulness of Practitioner-Led Pancreatic Cancer Screening

Author

Matsumoto, Kazuya, primary, Kushiyama, Yoshinori, additional, Izumi, Akio, additional, Ohnishi, Koji, additional, Miura, Masahiko, additional, Ohuchi, Yasufumi, additional, Hori, Ikuko, additional, Nakamura, Tomonori, additional, Hori, Kotaro, additional, Koshino, Kenji, additional, Kobayashi, Junko, additional, Yoshino, Nagisa, additional, Hoshino, Ushio, additional, Okumura, Takekiyo, additional, Tanimura, Takashi, additional, Tanaka, Shinsuke, additional, Tanaka, Shino, additional, Nabika, Tadashi, additional, Nozu, Tatsuaki, additional, Wakatsuki, Yutaka, additional, Katayama, Syunsuke, additional, Yoshioka, Shizue, additional, Ito, Kenichi, additional, Uchida, Akiko, additional, Yuhara, Noriji, additional, Noma, Hisashi, additional, and Isomoto, Hajime, additional

Published
2022
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3. Effects of anti-hypertensive drugs on esophageal body contraction

Author

Yoshida Koichi, Furuta Kenji, Adachi Kyoichi, Ohara Shunji, Morita Terumi, Tanimura Takashi, Nakata Shuji, Miki Masaharu, Koshino Kenji, Kinoshita, Yoshikazu, Yoshida Koichi, Furuta Kenji, Adachi Kyoichi, Ohara Shunji, Morita Terumi, Tanimura Takashi, Nakata Shuji, Miki Masaharu, Koshino Kenji, and Kinoshita, Yoshikazu

Published
2010

11. Effects of anti-hypertensive drugs on esophageal body contraction.

Author

Yoshida K, Furuta K, Adachi K, Ohara S, Morita T, Tanimura T, Nakata S, Miki M, Koshino K, and Kinoshita Y

Subjects
Adult, Atenolol pharmacology, Calcium Channel Blockers pharmacology, Gastrointestinal Motility drug effects, Humans, Losartan pharmacology, Male, Nifedipine pharmacology, Sympatholytics pharmacology, Antihypertensive Agents pharmacology, Esophagus drug effects, Esophagus physiology, Muscle, Smooth drug effects, Peristalsis drug effects
Abstract

Aim: To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possible relationship with gastro-esophageal reflux disease., Methods: Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine, losartan, and atenolol, as well as without any drug administration., Results: Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were significantly higher than those without medication in a supine position. On the other hand, peristaltic pressures under nifedipine administration were lower than those observed without drug administration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition, while the effects of nifedipine were the opposite., Conclusion: Among the anti-hypertensive drugs tested, atenolol enhanced esophageal motor activity, which was in contrast to nifedipine.

Published
2010
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