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2. A patient with recurrent strokes: multimodal imaging reveals two possible causes

Author

Giusca Sorin, Schreck Johannes, Karck Matthias, and Korosoglou Grigorios

Subjects
cardiac tumor, fibroma, embolic risk, cardiac ct, cardiac imaging, tumoră cardiacă, fibrom, risc embolic, ct cardiac, imagistică cardiacă, Internal medicine, RC31-1245
Abstract

An underlying cardio-embolic cause can be identified in a fifth of stroke patients. Cardiac tumors occur rarely in routine clinical practice but can cause severe complications such as heart failure, valve dysfunction, embolic events, or sudden cardiac death. Herein we present the case of a 67-year-old patient with a history of recurrent stroke in whom a patent foramen ovale (PFO) and a hypermobile structure attached to the aortic valve were diagnosed during a transesophageal examination. The structure was interpreted to be a papillary fibroelastoma. Coronary computed tomography angiography completed the diagnosis, helping to exclude a relevant coronary artery disease. The patient underwent an uneventful cardiac surgery with removal of the hypermobile structure and closure of the PFO. The histopathological analysis, however, was negative for elastin in the elastin stain, and thus the diagnosis of a cardiac fibroma was made. The case emphasizes the role of cardiovascular imaging in stroke patients as well as that of histopathological analysis.

Published
2022
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4. Lesion Localization and Limb Outcomes in Elderly Patients with and Without Type 2 Diabetes Mellitus Who Undergo Atherectomy-Assisted Endovascular Revascularization due to Symptomatic Peripheral Artery Disease.

Author

Katsiki, Niki, Geiss, Eva, Giesen, Alexander, Jehn, Amila, Rammos, Christos, Karcher, Jan C., Schöfthaler, Christoph, and Korosoglou, Grigorios

Abstract

Background/Objectives: Type 2 diabetes mellitus (T2DM) represents a major risk factor for peripheral artery disease (PAD). We aimed to evaluate the impact of T2DM on lesion localization and complexity, clinical presentation by Rutherford categories, and limb outcomes in elderly patients with symptomatic PAD undergoing endovascular revascularization. Methods: Five hundred consecutive patients with symptomatic infra-inguinal PAD who underwent rotational atherectomy-assisted endovascular revascularization were included. PAD clinical presentation and lesion localization were recorded. The primary endpoints were clinically driven target lesion revascularization (CD-TLR) and major amputation rates during follow-up. Results: Overall, 245/500 (49.0%) patients had T2DM, whereas 179 (35.8%) presented with lifestyle limiting claudication and 321 (64.2%) with critical limb-threatening ischemia (CLTI). Median age was 78.0 (IQR = 70.0–84.0) years, and 201 (40.2%) patients were female. The presence of T2DM was significantly more frequent in patients with CLTI vs. those with claudication (58.6 vs. 31.8%; p < 0.001). Furthermore, the percentage of patients with below-the-knee (BTK) lesions was significantly higher in patients with vs. without T2DM (40.7 vs. 27.5%, p = 0.0002). During median follow-up of 21.9 (IQR = 12.8–28.8) months, CD-TLR rates were similar in patients with vs. without T2DM (HR = 1.2, 95%CI = 0.8–2.0, p = 0.39). However, patients with T2DM had a ~5.5-fold increased risk for major above-the-ankle amputation (HR = 5.5, 95%CI = 1.6–19.0, p = 0.007). After adjustment for age, gender, lesion complexity, and calcification, T2DM remained predictive for major amputation (p = 0.04). Conclusions: T2DM is more frequently associated with CLTI, BTK-PAD, and amputations despite successful endovascular revascularization. More stringent surveillance of patients with PAD and T2DM is warranted to prevent atherosclerosis-related complications. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Successful intravascular lithotripsy after all other options failed with stent under-expansion: a case report and review of alternative options.

Author

Breitbart, Philipp, Billig, Hannah, Schöfthaler, Christoph, and Korosoglou, Grigorios

Abstract

Background Stent under-expansion, often caused by severe circumferential coronary calcification, must be prevented as it increases the risk of neoatherosclerosis and stent thrombosis. Intravascular lithotripsy (IVL) is an effective lesion preparation strategy to enable sufficient expansion of a stent that was initially not sufficiently expanded. Case summary A 62-year-old male patient presented in our emergency department due to unstable angina. Coronary angiography revealed one-vessel coronary artery disease with high-grade stenosis of the proximal to mid right coronary artery. Direct implantation of a drug-eluting stent was performed. However, stent under-expansion was noticed. Post-dilatation with semi-compliant balloon up to 24 bar was unsuccessful. Subsequent dilatation with an ultra-high-pressure OPN non-compliant balloon at 50 bar resulted to balloon rupture but stent under-expansion remained. Therefore, IVL was performed, resulting in complete stent expansion already at 4 bar. The patient was put on dual platelet treatment, and his further clinical course was uneventful after 6 months of follow-up. Discussion The present case report highlights the role of IVL as a safe and effective treatment option in case of immediate stent under-expansion. This has significant implications on daily practice as under-expansion may lead to high rates of in-stent restenosis and stent thrombosis. Furthermore, this case report underlines the impact of lesion preparation, even in presumably less complex lesion by angiographic criteria. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Awareness of strengths and weaknesses of Cardiovascular Magnetic Resonance Imaging (CMR) – Results from a questionnaire survey

Author

Zieschang, Victoria, primary, Beyer, Rebecca Elisabeth, additional, Müller, Maximilian Leo, additional, Trautmann, Frederike, additional, Kühne, Titus, additional, Nagel, Eike, additional, Rolf, Andreas, additional, Schuster, Andreas, additional, Korosoglou, Grigorios, additional, Steen, Henning, additional, Yilmaz, Ali, additional, Petersen, Steffen E, additional, Remppis, Bjoern Andrew, additional, Thiede, Gisela, additional, Nolden, Anna Clara, additional, and Kelle, Sebastian, additional

Published
2024
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8. Intraoperative Extravascular Ultrasound in the Identification of Flow-Limiting Dissections after Balloon Angioplasty in the Femoropopliteal Segment

Author

Mwipatayi, Bibombe Patrice, primary, Dodd, James, additional, Hanna, Joseph, additional, Gouëffic, Yann, additional, Brodmann, Marianne, additional, Guerra, Mercedes, additional, Schmidt, Andrej, additional, Loewe, Christian, additional, Grözinger, Gerd, additional, Korosoglou, Grigorios, additional, Lichtenberg, Michael, additional, and Deloose, Koen, additional

Published
2024
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9. Relationship between quality of life indicators and cardiac status indicators in chemotherapy patients

Author

Geršak Blaž Matija, Kukec Andreja, Steen Henning, Montenbruck Moritz, Šoštarič Maja, Schwarz Arne Kristian, Esch Sebastian, Kelle Sebastian, Giusca Sorin, Korosoglou Grigorios, Wülfing Pia, Dent Susan, and Lenihan Daniel

Subjects
antineoplastic agents, cardiotoxicity, ventricular function – left, ventricular function – right, quality of life, magnetic resonance imaging, cine, echocardiography, lymphoma, hodgkin disease, breast neoplasms, antineoplastični agensi, kardiotoksičnost, ventrikularna funkcija – levi, ventrikularna funkcija – desni, kakovost življenja, magnetnoresonančno slikanje, video, ehokardiografija, limfomi, hodgkinova bolezen, neoplazme dojk, Public aspects of medicine, RA1-1270
Abstract

With the aim of improving personalized treatment of patients on chemotherapy, the objective of the study was to assess the degree of association between selected Quality of life (QoL) indicators and both clinical and imaging cardiac status indicators when detecting deterioration in QoL of these patients.

Published
2021
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11. Combined non-invasive assessment of endothelial shear stress and molecular imaging of inflammation for the prediction of inflamed plaque in hyperlipidaemic rabbit aortas

Author

Gitsioudis, Gitsios, Chatzizisis, Yiannis S, Wolf, Peter, Missiou, Anna, Antoniadis, Antonios P, Mitsouras, Dimitrios, Bartling, Sönke, Arica, Zeynep, Stuber, Matthias, Rybicki, Frank J, Nunninger, Max, Erbel, Christian, Libby, Peter, Giannoglou, George D, Katus, Hugo A, and Korosoglou, Grigorios

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Biomedical Imaging, Atherosclerosis, Bioengineering, Animals, Aorta, Biopsy, Needle, Computed Tomography Angiography, Confidence Intervals, Disease Models, Animal, Disease Progression, Endothelium, Vascular, Hyperlipidemias, Immunohistochemistry, Inflammation, Linear Models, Magnetic Resonance Imaging, Male, Molecular Imaging, Observer Variation, Plaque, Atherosclerotic, Predictive Value of Tests, ROC Curve, Rabbits, Random Allocation, Reproducibility of Results, Sensitivity and Specificity, Shear Strength, Ultrasonography, Interventional, atherosclerosis, hyperlipidaemic rabbits, endothelial shear stress, molecular imaging, magnetic resonance imaging, computed tomography angiography, Cardiovascular medicine and haematology
Abstract

AimsTo evaluate the incremental value of low endothelial shear stress (ESS) combined with high-resolution magnetic resonance imaging (MRI)- and computed tomography angiography (CTA)-based imaging for the prediction of inflamed plaque.Methods and resultsTwelve hereditary hyperlipidaemic rabbits underwent quantitative analysis of plaque in the thoracic aorta with 256-slice CTA and USPIO-enhanced (ultra-small superparamagnetic nanoparticles, P904) 1.5-T MRI at baseline and at 6-month follow-up. Computational fluid dynamics using CTA-based 3D reconstruction of thoracic aortas identified the ESS patterns in the convex and concave curvature subsegments of interest. Subsegments with low baseline ESS exhibited significant increase in wall thickness and plaque inflammation by MRI, in non-calcified plaque burden by CTA, and developed increased plaque size, lipid and inflammatory cell accumulation (high-risk plaque features) at follow-up by histopathology. Multiple regression analysis identified baseline ESS and inflammation by MRI to be independent predictors of plaque progression, while receiver operating curve analysis revealed baseline ESS alone or in combination with inflammation by MRI as the strongest predictor for augmented plaque burden and inflammation (low ESS at baseline: AUC = 0.84, P < 0.001; low ESS and inflammation by molecular MRI at baseline: AUC = 0.89, P < 0.001).ConclusionLow ESS predicts progression of plaque burden and inflammation as assessed by non-invasive USPIO-enhanced MRI. Combined non-invasive assessment of ESS and imaging of inflammation may serve to predict plaque with high-risk features.

Published
2017

12. Syncope due to recurrent ventricular tachycardias after transcatheter aortic valve implantation with unexpected diagnosis in cardiac computed tomography: a case report.

Author

Breitbart, Philipp, Billig, Hannah, André, Florian, Frey, Norbert, and Korosoglou, Grigorios

Subjects
HEART valve prosthesis implantation, COMPUTED tomography, ARRHYTHMIA, SYNCOPE, MYOCARDIAL infarction, DIAGNOSIS, PERCUTANEOUS coronary intervention
Abstract

Background Delayed coronary obstruction (DCO) is a rare but potentially life-threatening complication after transcatheter aortic valve implantation (TAVI) mostly affecting the left main coronary artery (LMCA) and often caused by prosthesis endothelialization or thrombus formations. Herein, we report an unusual case of a delayed LMCA-obstruction caused by a calcium nodule, which was diagnosed 4 months after TAVI due to recurrent ventricular tachycardia (VT) episodes. Case summary A 73-year-old patient was readmitted to an external hospital with syncope three months after TAVI. Fast VT could be induced in electrophysiological examination, why the patient received a two-chamber implantable cardioverter defibrillator (ICD). However, after 1 month the patient was readmitted to our department with another syncope. Implantable cardioverter defibrillator records revealed multiple fast VT episodes (200–220 b.p.m.). In addition, the patient reported new-onset exertional dyspnoea (New York Class Association Stage III) and elevated high-sensitive cardiac troponin of 115 ng/L. Due to the symptoms and laboratory markers indicating potential myocardial ischaemia, a cardiac computed tomography angiography (CCTA) was performed. Cardiac computed tomography angiography revealed obstruction of the LMCA likely caused by calcium shift during TAVI. After CCTA-guided percutaneous coronary intervention, patient's course remained uneventful. Discussion The present case report highlights the role of CCTA as a powerful non-invasive diagnostic tool in complex settings after TAVI. Delayed coronary obstruction as a procedural complication can occur after TAVI and manifest with various symptoms, including new-onset or recurrent VTs, like in the present case. Cardiac computed tomography angiography provided accurate assessment of the implanted prosthesis and detection of DCO, thus guiding the subsequent PCI. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Comparison of Two Contemporary Quantitative Atherosclerotic Plaque Assessment Tools for Coronary Computed Tomography Angiography: Single-Center Analysis and Multi-Center Patient Cohort Validation

Author

Weichsel, Loris, primary, Giesen, Alexander, additional, André, Florian, additional, Renker, Matthias, additional, Baumann, Stefan, additional, Breitbart, Philipp, additional, Beer, Meinrad, additional, Maurovitch-Horvat, Pal, additional, Szilveszter, Bálint, additional, Vattay, Borbála, additional, Buss, Sebastian J., additional, Marwan, Mohamed, additional, Giannopoulos, Andreas A., additional, Kelle, Sebastian, additional, Frey, Norbert, additional, and Korosoglou, Grigorios, additional

Published
2024
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19. Endovascular Versus Surgical Treatment for All Comer Patients With Prosthetic Bypass Graft Occlusion: The Multicentre ENSUPRO Study

Author

Korosoglou, Grigorios, primary, Torsello, Giovanni, additional, Saratzis, Athanasios, additional, Isernia, Giacomo, additional, Kontopodis, Nikolaos, additional, González, Teresa Martín, additional, Jacobs, Karen, additional, Van Herzeele, Isabelle, additional, Zayed, Hany, additional, Stavroulakis, Konstantinos, additional, Korosoglou, Grigorios, additional, Argiriou, Angeliki, additional, Konstantinou, Nikolaos, additional, Saratzis, Nikolaos, additional, Henriques, Mickael, additional, Troisi, Nicola, additional, Giordano, Antonio N., additional, D’Oria, Mario, additional, Fazzini, Stefano, additional, Nasr, Bahaa, additional, Martelli, Massimiliano, additional, and Caradu, Caroline, additional

Published
2023
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20. TCT-719 Intravascular Lithotripsy in Peripheral Lesions With Severe Calcification and its Role in TAVR Procedure: A Multicenter Systematic Review and Meta-Analysis

Author

Sagris, Marios, primary, Ktenopoulos, Nikolaos, additional, Soulaidopoulos, Stergios, additional, Dimitriadis, Kyriakos, additional, Papanikolaou, Angelos, additional, Tzoumas, Andreas, additional, Terentes-Printzios, Dimitrios, additional, Lichtenberg, Michael, additional, Korosoglou, Grigorios, additional, Tousoulis, Dimitrios, additional, Honton, Benjamin, additional, Toutouzas, Konstantinos, additional, and Tsioufis, Konstantinos, additional

Published
2023
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21. TCT-713 Evaluating the Efficacy of Intravascular Lithotripsy in Coronary Lesions With Severe Calcification: A Multicenter Systematic Review and Meta-Analysis

Author

Sagris, Marios, primary, Ktenopoulos, Nikolaos, additional, Dimitriadis, Kyriakos, additional, Papanikolaou, Angelos, additional, Tzoumas, Andreas, additional, Terentes-Printzios, Dimitrios, additional, Synetos, Andreas, additional, Soulaidopoulos, Stergios, additional, Lichtenberg, Michael, additional, Korosoglou, Grigorios, additional, Toutouzas, Konstantinos, additional, Honton, Benjamin, additional, and Tsioufis, Konstantinos, additional

Published
2023
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23. Editor's Choice – RANDOMisation Screening for Drug coated or Drug Eluting Device Randomised Trials Among Patients Undergoing Endovascular FemorOPopliteal Procedures (RANDOM-STOP study)

Author

Stavroulakis, Konstantinos, primary, Katsogridakis, Emmanuel, additional, Torsello, Giovanni, additional, Zayed, Hany, additional, van Herzeele, Isabelle, additional, Coscas, Raphael, additional, Nasr, Bahaa, additional, Gonzalez, Teresa Martin, additional, Troisi, Nicola, additional, Saratzis, Athanasios, additional, Bohnert, Ambre, additional, Martin-Gonzalez, Teresa, additional, Torsello, Giovanni B., additional, Wichmann, Katrin, additional, Cardona, Yamel Gloria, additional, Stavroulakis, Christiane, additional, Stavroulakis, Konstantinos, additional, Tsilimparis, Nikolaos, additional, Konstantinou, Nikolaos, additional, Croo, Alexander, additional, Jacobs, Karen, additional, Pecceu, Stefanie, additional, Van Langenhove, Karen, additional, Mercier, Lucie, additional, Simonte, Gioele, additional, Terpin, Andrea Maria, additional, Isernia, Giacomo, additional, Furlan, Federico, additional, Frigatti, Paolo, additional, Canovaro, Francesco, additional, Torri, Lorenzo, additional, D'Oria, Mario, additional, Lepidi, Sandro, additional, Magalhães, Tiago, additional, Pedro, Luís Mendes, additional, Marone, Enrico Maria, additional, Marazzi, Giulia, additional, Rinaldi, Luigi Federico, additional, Thulasidasan, Narayanan, additional, Benton, Lily, additional, Gregory, Mark, additional, Asciutto, Giuseppe, additional, Korosoglou, Grigorios, additional, and Torsello, Giovanni Federico, additional

Published
2023
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24. Endovascular interventions in outpatient care

Author

Thieme, Marcus, Krankenberg, Hans, Schilling, Tom, Betge, Stefan, Korosoglou, Grigorios, Rammos, Christos, Vosseler, Markus, Espinola-Klein, Christine, Heilmeier, Britta, Müller, Oliver J., Langhoff, Ralf, Malyar, Nasser, Blessing, Erwin, Caspary, Lutz, Linnemann, Birgit, Heiss, Christian, and Ito, Wulf

Subjects
Medizin, Cardiology and Cardiovascular Medicine
Abstract

Summary: Endovascular arterial revascularisations for the treatment of symptomatic peripheral arterial disease are constantly increasing in importance and number due to the changing age structure and high numbers of comorbidities in the German population. Patients with peripheral artery disease are often at increased risk for peri- and post-procedural complications including severe cardiovascular events. Due to limited financial and human resources and considerable risks of hospitalization, endovascular interventions that were previously reserved for hospitalized patients are now progressively considered to be performed as day case procedures. More than one third of these procedures are performed in Germany by internists with a specialization in angiology. In the current position paper the German Society of Angiology endorsed by the European Society of Vascular Medicine, summarizes the requirements and risk factors to be considered for the planning, safe performance and post procedural care of endovascular revascularizations in outpatients. The performance of endovascular procedures for peripheral artery disease both in hospitalised and outpatients should be accompanied by a mandatory quality assurance process that should not only capture procedural data, but also require documentation of complications and longterm outcome.

Published
2023

28. Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry)

Author

Schroth, Daniel, primary, Garg, Ria, additional, Bocova, Xhoi, additional, Hansmann, Jochen, additional, Haass, Markus, additional, Yan, Andrew, additional, Fernando, Carlos, additional, Chacko, Binita, additional, Oikonomou, Anastasia, additional, White, James, additional, Alhussein, Muhammad Mustafa, additional, Giusca, Sorin, additional, Ochs, Andreas, additional, Korosoglou, Grigorios, additional, André, Florian, additional, Friedrich, Matthias G., additional, and Ochs, Marco, additional

Published
2023
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30. Ultrasound-assisted catheter-directed thrombolysis in a patient with COVID-19 infection and bilateral intermediate-to-high-risk pulmonary embolism: a case report.

Author

Korosoglou, Grigorios, Mouselimis, Dimitrios, Koenig, Elke, and Konstantinides, Stavros

Subjects
PULMONARY embolism, COVID-19, RETURN of spontaneous circulation, THROMBOLYTIC therapy, ACUTE coronary syndrome, CARDIOVASCULAR diseases
Abstract

Background Acute pulmonary embolism (PE) is a common cardiovascular disorder, potentially associated with high morbidity and mortality rates. Case summary Herein, we report on a patient with COVID-19 infection and bilateral PE, who presented after cardiovascular resuscitation with return of spontaneous circulation. Initially, an acute coronary syndrome was suspected but bedside echocardiography showed dilatation of the right ventricle (RV) and RV dysfunction, helping to establish the diagnosis of acute intermediate-to-high-risk PE, which was subsequently confirmed by contrast-enhanced computed tomography pulmonary angiography. The patient was successfully treated using low-dose (12 mg of tissue plasminogen) ultrasound-assisted catheter-directed thrombolysis, which resulted in prompt clinical improvement and reversal of RV dysfunction without bleeding complications. Discussion This case demonstrates the importance of echocardiography for the differential diagnosis of PE and of catheter-directed thrombolysis for its treatment in patients with intermediate-to-high-risk and high-risk PEs. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Crossing Algorithm for Infrainguinal Chronic Total Occlusions

Author

Korosoglou, Grigorios, primary, Schmidt, Andrej, additional, Lichtenberg, Michael, additional, Torsello, Giovanni, additional, Grözinger, Gerd, additional, Mustapha, Jihad, additional, Varcoe, Ramon L., additional, Zeller, Thomas, additional, Blessing, Erwin, additional, and Langhoff, Ralf, additional

Published
2023
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40. Different endovascular modalities of treatment for isolated atherosclerotic popliteal artery lesions (EMO-POP) registry

Author

Troisi, Nicola, primary, Saratzis, Athanasios, additional, Katsogridakis, Emmanuel, additional, Stavroulakis, Konstantinos, additional, Berchiolli, Raffaella, additional, Zayed, Hany, additional, Torsello, Giovanni, additional, Brunschot, Denise Özdemir-van, additional, González, Teresa Martín, additional, Denisselle, Thomas, additional, Korosoglou, Grigorios, additional, Isernia, Giacomo, additional, Michelagnoli, Stefano, additional, Giordano, Antonio Nicola, additional, Daonas, Konstantinos P., additional, Pitoulias, Apostolos G., additional, Spiliopoulos, Stavros, additional, Martelli, Massimiliano, additional, Settembrini, Alberto Maria, additional, and D’Oria, Mario, additional

Published
2023
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41. Cardiac Troponins for the Clinical Management of Patients with Claudication and without Cardiac Symptoms

Author

Mouselimis, Dimitrios, primary, Hagstotz, Saskia, additional, Lichtenberg, Michael, additional, Donas, Konstantinos P., additional, Heinrich, Ulrike, additional, Avranas, Konstantinos, additional, Dimitriadis, Zisis, additional, Blessing, Erwin, additional, Langhoff, Ralf, additional, Frey, Norbert, additional, Katus, Hugo A., additional, and Korosoglou, Grigorios, additional

Published
2022
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42. Editorial: Atherosclerosis and functional imaging

Author

Huang, Jei-Yie, primary, Lin, Yen-Hung, additional, Hung, Chung-Lieh, additional, Chen, Wen-Pin, additional, Tamaki, Nagara, additional, Bax, Jeroen J., additional, Morris, Daniel A., additional, Korosoglou, Grigorios, additional, and Wu, Yen-Wen, additional

Published
2022
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