Search

Your search keyword '"Koponen, Milja"' showing total 7 results
Start Over Author "Koponen, Milja" Search Limiters Full Text
7 results on '"Koponen, Milja"'

1. Response Letter to Koivisto et al. 'Evaluating the Theoretical Background of STOFFENMANAGER® and the Advanced REACH Tool'

Author

Fransman, Wouter, Arnone, Mario, Borghi, Francesca, Cattaneo, Andrea, Cavallo, Domenico M, Cherrie, John W, Franken, Remy, Galea, Karen S, van der Haar, Rudolf, Heussen, Gerardus A H, Jensen, Keld A, Koponen, Milja, Koppisch, Dorothea, Kromhout, Hans, Luo, Yu-Syuan, McNally, Kevin, Säämänen, Arto, Spinazzè, Andrea, van Tongeren, Martie, Vanoirbeek, Jeroen, Verpaele, Steven, Vetter, Daniel, Viegas, Susana, Warren, Nick, Fransman, Wouter, Arnone, Mario, Borghi, Francesca, Cattaneo, Andrea, Cavallo, Domenico M, Cherrie, John W, Franken, Remy, Galea, Karen S, van der Haar, Rudolf, Heussen, Gerardus A H, Jensen, Keld A, Koponen, Milja, Koppisch, Dorothea, Kromhout, Hans, Luo, Yu-Syuan, McNally, Kevin, Säämänen, Arto, Spinazzè, Andrea, van Tongeren, Martie, Vanoirbeek, Jeroen, Verpaele, Steven, Vetter, Daniel, Viegas, Susana, and Warren, Nick

Abstract

In this article, we have responded to the key statements in the article by Koivisto et al. (2022) that were incorrect and considered to be a biased critique on a subset of the exposure models used in Europe (i.e. ART and Stoffenmanager®) used for regulatory exposure assessment. We welcome scientific discussions on exposure modelling (as was done during the ISES Europe workshop) and criticism based on scientific evidence to contribute to the advancement of occupational exposure estimation tools. The tiered approach to risk assessment allows various exposure assessment models from screening tools (control/hazard banding) through to higher-tiered approaches. There is a place for every type of model, but we do need to recognize the cost and data requirements of highly bespoke assessments. That is why model developers have taken pragmatic approaches to develop tools for exposure assessments based on imperfect data. We encourage Koivisto et al. to focus on further scientifically robust work to develop mass-balance models and by independent external validations studies, compare these models with alternative model tools such as ART and Stoffenmanager®.

Published
2022

2. Response Letter to Koivisto et al. 'Evaluating the Theoretical Background of STOFFENMANAGER® and the Advanced REACH Tool'

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Fransman, Wouter, Arnone, Mario, Borghi, Francesca, Cattaneo, Andrea, Cavallo, Domenico M, Cherrie, John W, Franken, Remy, Galea, Karen S, van der Haar, Rudolf, Heussen, Gerardus A H, Jensen, Keld A, Koponen, Milja, Koppisch, Dorothea, Kromhout, Hans, Luo, Yu-Syuan, McNally, Kevin, Säämänen, Arto, Spinazzè, Andrea, van Tongeren, Martie, Vanoirbeek, Jeroen, Verpaele, Steven, Vetter, Daniel, Viegas, Susana, Warren, Nick, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Fransman, Wouter, Arnone, Mario, Borghi, Francesca, Cattaneo, Andrea, Cavallo, Domenico M, Cherrie, John W, Franken, Remy, Galea, Karen S, van der Haar, Rudolf, Heussen, Gerardus A H, Jensen, Keld A, Koponen, Milja, Koppisch, Dorothea, Kromhout, Hans, Luo, Yu-Syuan, McNally, Kevin, Säämänen, Arto, Spinazzè, Andrea, van Tongeren, Martie, Vanoirbeek, Jeroen, Verpaele, Steven, Vetter, Daniel, Viegas, Susana, and Warren, Nick

Published
2022

5. Stoffenmanager-Suomi

Author

Koponen, Milja, Kallio, Niina, and Säämänen, Arto

Abstract

Raportin tarkoituksena on kuvata Stoffenmanagerin käännös- ja lanseeraustyön haasteita, sekä avata työkalujen sisältöä niille, jotka haluavat perehtyä tarkemmin esimerkiksi control banding -periaatteeseen, kvantitatiiviseen altistumisenarviointiin tai nanomateriaalien riskinhallintaan.

Published
2012

6. Consolidating Exposure Scenario Information for Mixtures—Experiences and Challenges.

Author

Taxell, Piia, Koponen, Milja, Kallio, Niina, and Santonen, Tiina

Subjects
*RISK assessment, *RISK management in business, *ORGANIC compounds, *RESEARCH funding, *OCCUPATIONAL hazards, *ENVIRONMENTAL exposure, *STATISTICAL models
Abstract

Introduction: The requirements of the European Union Regulation on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), including the preparation of exposure scenarios for the communication of safe use, are focused on single substances. Since the chemical products used at workplaces are typically mixtures, it is important to ensure that accurate information is available regarding their safe use. The focus of the present study was on the methods for consolidating (combining) the information presented in the exposure scenarios of the individual components of a mixture. Methods: We tested the applicability and comparability of three methods for consolidating the exposure scenario information on six real products, focusing on occupational exposure. Two of the reviewed methods were based on the identification of the critical components that determine the health effects and risk management of the product, and one was based on the selection of the most stringent risk management measures presented in the exposure scenarios of the components. Results: The differences in the critical components recognised by the two critical component-based methods revealed limitations in both of the methods. The quality and comprehensiveness of the consolidated scenarios produced by the two methods were generally of the same level, depended directly on the content of the exposure scenarios of the critical components. Choosing the most stringent risk management measures improved the comprehensiveness of the scenarios. All of the examined methods run the risk of communicating over-precautionary measures if the concentration of the components determining the level of protection is not taken into consideration. Conclusions: Of the three methods considered, we recommend the selection of the most stringent operational conditions and risk management measures as a conservative default approach for consolidating exposure scenario information. If a critical component-based approach is used, checking the adequacy of the consolidated scenario for the other components of the mixture is recommended. With all of the methods, further modification of the consolidated scenario may be necessary to achieve the intended level of protection. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results