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216 results on '"Koh, Tse-Hsien"'

1. Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study

Author

Suphavilai, Chayaporn, Ko, Karrie Kwan Ki, Lim, Kar Mun, Tan, Mei Gie, Boonsimma, Patipan, Chu, Joash Jun Keat, Goh, Sui Sin, Rajandran, Prevena, Lee, Lai Chee, Tan, Kwee Yuen, Shaik Ismail, Bushra Binte, Aung, May Kyawt, Yang, Yong, Sim, Jean Xiang Ying, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, Spruijtenburg, Bram, Chan, Kian Sing, Oon, Lynette Lin Ean, Tan, Ai Ling, Tan, Yen Ee, Wijaya, Limin, Tan, Ban Hock, Ling, Moi Lin, Koh, Tse Hsien, Meis, Jacques F, Tsui, Clement Kin Ming, and Nagarajan, Niranjan

Published
2024
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2. Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales

Author

Marimuthu, Kalisvar, Venkatachalam, Indumathi, Koh, Vanessa, Harbarth, Stephan, Perencevich, Eli, Cherng, Benjamin Pei Zhi, Fong, Raymond Kok Choon, Pada, Surinder Kaur, Ooi, Say Tat, Smitasin, Nares, Thoon, Koh Cheng, Tambyah, Paul Anantharajah, Hsu, Li Yang, Koh, Tse Hsien, De, Partha Pratim, Tan, Thean Yen, Chan, Douglas, Deepak, Rama Narayana, Tee, Nancy Wen Sim, Kwa, Andrea, Cai, Yiying, Teo, Yik-Ying, Thevasagayam, Natascha May, Prakki, Sai Rama Sridatta, Xu, Weizhen, Khong, Wei Xin, Henderson, David, Stoesser, Nicole, Eyre, David W., Crook, Derrick, Ang, Michelle, Lin, Raymond Tzer Pin, Chow, Angela, Cook, Alex R., Teo, Jeanette, and Ng, Oon Tek

Published
2022
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3. Author Correction: The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone

Author

Chen, Swaine L., Ding, Ying, Apisarnthanarak, Anucha, Kalimuddin, Shirin, Archuleta, Sophia, Omar, Sharifah Faridah Syed, De, Partha Pratim, Koh, Tse Hsien, Chew, Kean Lee, Atiya, Nadia, Suwantarat, Nuntra, Velayuthan, Rukumani Devi, Wong, Joshua Guo Xian, and Lye, David C.

Published
2021
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4. Acquisition of Plasmid with Carbapenem-Resistance Gene [bla.sub.KPC2] in Hypervirulent Klebsiella pneumoniae, Singapore

Author

Chen, Yahua, Marimuthu, Kalisvar, Teo, Jeanette, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, De Wang, Liang, Prakki, Sai Rama Sridatta, Xu, Weizhen, Tan, Yi Han, Nguyen, Lan Chi, Koh, Tse Hsien, Ng, Oon Tek, and Gan, Yunn-Hwen

Subjects
Klebsiella infections -- Genetic aspects -- Care and treatment -- Development and progression, Microbial drug resistance -- Genetic aspects, Sentinel surveillance, Plasmids -- Identification and classification, Diseases, Health
Abstract

The rise of multidrug-resistant (MDR) Enterobacteriaceae prompted the World Health Organization to classify carbapenem-resistant Enterobacteriaceae, of which Klebsiella is the most common genus, on the global priority list of antibiotic-resistant [...]

Published
2020
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6. SG-APSIC1097: The impact of COVID-19 on the incidence of carbapenem-resistant Enterobacterales (CRE) in Singapore: An interrupted time-series analysis

Author

Ong, Chong Hui Clara, primary, Cheng, Thoon Koh, additional, Pada, Surinder Kaur M S, additional, Narayana, Deepak Rama, additional, Ooi, Say Tat, additional, Smitasin, Nares, additional, Fong, Kok Choon Raymond, additional, Koh, Tse Hsien, additional, Cherng, Pei Zhi Benjamin, additional, Lin, Raymond, additional, Pratim, De Partha, additional, Yang, Hsu Li, additional, Teo, Jeanette, additional, Ng, Oon Tek, additional, Venkatachalam, Indumathi, additional, and Marimuthu, Kalisvar, additional

Published
2023
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7. Impact of COVID-19 pandemic on carbapenem-resistant Enterobacterales incidence in the South-East Asia region: an observational study

Author

Linn, Kyaw Zaw, primary, Sutjipto, Stephanie, additional, Ng, Oon Tek, additional, Teo, Jeanette, additional, Cherng, Benjamin Pei Zhi, additional, Tan, Thean Yen, additional, Pada, Surinder Kaur, additional, Ooi, Say Tat, additional, Smitasin, Nares, additional, Thoon, Koh Cheng, additional, Huan, Xiaowei, additional, De, Partha Pratim, additional, Chan, Douglas, additional, Tee, Nancy Wen Sim, additional, Ang, Michelle, additional, Hsu, Li Yang, additional, Lin, Raymond Tzer Pin, additional, Ng, Tong Yong, additional, Deepak, Rama Narayana, additional, Koh, Tse Hsien, additional, Apisarnthanarak, Anucha, additional, Ponnampalavanar, Sasheela, additional, Venkatachalam, Indumathi, additional, and Marimuthu, Kalisvar, additional

Published
2023
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9. Clonal serotype 1c multidrug-resistant Shigella flexneri detected in multiple institutions by sentinel-site sequencing

Author

Ko, Karrie K. K., primary, Chu, Joash Jun Keat, additional, Lim, Kar Mun, additional, Yingtaweesittikul, Hatairat, additional, Huang, Wenjie, additional, Tan, Shireen Yan Ling, additional, Goh, Kenneth Choon Meng, additional, Tan, Si Huei, additional, Ng, Tong Yong, additional, Maiwald, Matthias, additional, Chia, Jonathan Wei Zhong, additional, Cao, Delphine Yanhong, additional, Tan, Yen Ee, additional, Sim, James Heng Chiak, additional, Koh, Tse Hsien, additional, Nagarajan, Niranjan, additional, and Suphavilai, Chayaporn, additional

Published
2022
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10. Characterisation of Salmonella Enteritidis ST11 and ST1925 Associated with Human Intestinal and Extra-Intestinal Infections in Singapore

Author

Aung, Kyaw Thu, primary, Khor, Wei Ching, additional, Ong, Kar Hui, additional, Tan, Wei Ling, additional, Wong, Zhi Ning, additional, Oh, Jia Quan, additional, Wong, Wai Kwan, additional, Tan, Brian Zi Yan, additional, Maiwald, Matthias, additional, Tee, Nancy Wen Sim, additional, Barkham, Timothy, additional, Koh, Tse Hsien, additional, Dalsgaard, Anders, additional, Chen, Swaine L., additional, Schlundt, Joergen, additional, and Ng, Lee Ching, additional

Published
2022
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15. Antimicrobial drug resistance in Singapore hospitals

Author

Hsu, Li-Yang, Tan, Thean-Yen, Jureen, Roland, Koh, Tse-Hsien, Krishnan, Prabha, Lin, Raymond Tzer-Pin, Tee, Nancy Wen-Sin, and Tambyah, Paul Ananth

Subjects
Hospital patients -- Health aspects, Hospital patients -- Surveys, Drug resistance in microorganisms -- Surveys, Drug resistance in microorganisms -- Research
Abstract

A new national antimicrobial resistance surveillance program in Singapore public hospitals that uses WHONET detected high levels of methicillin resistance among Staphylococcus aureus (35.3%), carbapenem resistance among Acinetobacter spp. (49.6%), [...]

Published
2007

18. Elimination of Extracellular Adenosine Triphosphate for the Rapid Prediction of Quantitative Plate Counts in 24 h Time-Kill Studies against Carbapenem-Resistant Gram-Negative Bacteria

Author

Cai, Yiying, primary, Ng, Jonathan J., additional, Leck, Hui, additional, Teo, Jocelyn Q., additional, Goh, Jia-Xuan, additional, Lee, Winnie, additional, Koh, Tse-Hsien, additional, Tan, Thuan-Tong, additional, Lim, Tze-Peng, additional, and Kwa, Andrea L., additional

Published
2020
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22. Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli

Author

Boulouis, Caroline, primary, Sia, Wan Rong, additional, Gulam, Muhammad Yaaseen, additional, Teo, Jocelyn Qi Min, additional, Png, Yi Tian, additional, Phan, Thanh Kha, additional, Mak, Jeffrey Y. W., additional, Fairlie, David P., additional, Poon, Ivan K. H., additional, Koh, Tse Hsien, additional, Bergman, Peter, additional, Lim, Chwee Ming, additional, Wang, Lin-Fa, additional, Kwa, Andrea Lay Hoon, additional, Sandberg, Johan K., additional, and Leeansyah, Edwin, additional

Published
2020
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23. Determining the Development of Persisters in Extensively Drug-Resistant Acinetobacter baumannii upon Exposure to Polymyxin B-Based Antibiotic Combinations Using Flow Cytometry

Author

Wong, Fiona Hui-Sian, primary, Cai, Yiying, additional, Leck, Hui, additional, Lim, Tze-Peng, additional, Teo, Jocelyn Qi-Min, additional, Lee, Winnie, additional, Koh, Tse Hsien, additional, Tan, Thuan Tong, additional, Tan, Kar Wai, additional, and Kwa, Andrea Lay-Hoon, additional

Published
2020
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28. One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia

Author

Barkham, Timothy, primary, Zadoks, Ruth N., additional, Azmai, Mohammad Noor Amal, additional, Baker, Stephen, additional, Bich, Vu Thi Ngoc, additional, Chalker, Victoria, additional, Chau, Man Ling, additional, Dance, David, additional, Deepak, Rama Narayana, additional, van Doorn, H. Rogier, additional, Gutierrez, Ramona A., additional, Holmes, Mark A., additional, Huong, Lan Nguyen Phu, additional, Koh, Tse Hsien, additional, Martins, Elisabete, additional, Mehershahi, Kurosh, additional, Newton, Paul, additional, Ng, Lee Ching, additional, Phuoc, Nguyen Ngoc, additional, Sangwichian, Ornuma, additional, Sawatwong, Pongpun, additional, Surin, Uraiwan, additional, Tan, Thean Yen, additional, Tang, Wen Ying, additional, Thuy, Nguyen Vu, additional, Turner, Paul, additional, Vongsouvath, Manivanh, additional, Zhang, Defeng, additional, Whistler, Toni, additional, and Chen, Swaine L., additional

Published
2019
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30. Streptococcus iniae discitis in Singapore

Author

Koh, Tse Hsien, Kurup, Asok, and Chen, John

Abstract

To the Editor: Streptococcus iniae is a well-recognized fish pathogen that can cause meningoencephalitis in tilapia and trout (1) and necrotizing myositis in red drum (2). We describe the first [...]

Published
2004

31. CTX-M and plasmid-mediated AmpC-producing Enterobacteriaceae, Singapore

Author

Koh, Tse Hsien, Yeng Wang, Grace Chee, Sng, Li-Hwei, Yi, Zhao, and Koh, Tse Yuen

Subjects
Enzymes
Abstract

To the Editor: In gram-negative bacteria, [beta]-lactamases are an important cause of antimicrobial resistance. In the 1990s, several new [beta]-lactamases, including CTX-M type and plasmid-mediated AmpC [beta]-lactamases, emerged. CTX-M extended [...]

Published
2004

32. Genotypes and virulence in serotype K2 Klebsiella pneumoniae from liver abscess and non-infectious carriers in Hong Kong, Singapore and Taiwan

Author

Lin, Jung-Chung, Koh, Tse Hsien, Lee, Nelson, Fung, Chang-Phone, Chang, Feng-Yee, Tsai, Yu-Kuo, Ip, Margaret, and Siu, L Kristopher

Subjects
Health
Abstract

In Klebsiella pneumoniae liver abscess (KP-LA), K. pneumonia e K2 is the most frequently isolated serotype after K1, but this serotype has been much less studied. In the present study, the molecular types sequences type (MLST) of serotype K2 isolates from three different regions in Asia were identified and the virulence of these isolates was investigated. Eight different MLSTs were found among 26 isolates (ST 65, 66, 86, 373, 374, 375, 380, and 434). There were two major MLST groups, ST-65-like (42%) and ST86-like (46%). No isolates contained allS while all isolates contained rmpA. The prevalence of aerobactin gene and kfu were 25/26 (96%) and 3/26 (11.5%) respectively. Although liver abscess isolates were generally more resistant (11/15 isolates) to serum killing, there was no specific distribution of serum killing resistant or susceptible ST types between stool carriage and liver abscess isolates. Neutrophil phagocytosis showed that the liver abscess and carriage isolates varied in their susceptibility to phagocytosis. Strains with resistance to both neutrophil phagocytosis and serum killing were generally hypervirulent with lethality at LD.sub.50 < 10.sup.3 colony forming units by intraperitoneal injection. In conclusion, Anti-phagocytosis and resistance to serum killing are two parameters that most predict hyperviurlence in serotype K2 isolates. Unlike serotype K1 KP-LA that mainly belong to ST-23, ST-65-like and -86-like are the two major MLST types among serotype K2 isolates from Singapore, Hong Kong and Taiwan. Keywords: Liver abscess, Klebsiella pneumoniae, MLST, Author(s): Jung-Chung Lin[sup.1] , Tse Hsien Koh[sup.2] , Nelson Lee[sup.3] , Chang-Phone Fung[sup.4] , Feng-Yee Chang[sup.1] , Yu-Kuo Tsai[sup.5] , Margaret Ip[sup.6] and L Kristopher Siu[sup.1,5,7] Introduction Klebsiella pneumoniae liver [...]

Published
2014
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35. Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination

Author

Lam, Margaret M. C., primary, Wyres, Kelly L., additional, Duchêne, Sebastian, additional, Wick, Ryan R., additional, Judd, Louise M., additional, Gan, Yunn-Hwen, additional, Hoh, Chu-Han, additional, Archuleta, Sophia, additional, Molton, James S., additional, Kalimuddin, Shirin, additional, Koh, Tse Hsien, additional, Passet, Virginie, additional, Brisse, Sylvain, additional, and Holt, Kathryn E., additional

Published
2018
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36. Nod2 is required for the early innate immune clearance of Acinetobacter baumannii from the lungs

Author

Kale, Sandeep D., primary, Dikshit, Neha, additional, Kumar, Pankaj, additional, Balamuralidhar, Vanniarajan, additional, Khameneh, Hanif Javanmard, additional, Bin Abdul Malik, Najib, additional, Koh, Tse Hsien, additional, Tan, Gladys Gek Yen, additional, Tan, Thuan Tong, additional, Mortellaro, Alessandra, additional, and Sukumaran, Bindu, additional

Published
2017
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39. Evaluating Polymyxin B-Based Combinations against Carbapenem-Resistant Escherichia coli in Time-Kill Studies and in a Hollow-Fiber Infection Model

Author

Cai, Yiying, primary, Lim, Tze-Peng, additional, Teo, Jocelyn Qi-Min, additional, Sasikala, Suranthran, additional, Chan, Eric Chun Yong, additional, Hong, Yan Jun, additional, Lee, Winnie, additional, Tan, Thean Yen, additional, Tan, Thuan Tong, additional, Koh, Tse Hsien, additional, Hsu, Li Yang, additional, and Kwa, Andrea L., additional

Published
2017
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40. EMRSA-15 Bacteremia is not Associated with a Worse Outcome Compared with Bacteremia Caused by Multidrug-Resistant MRSA

Author

Hsu, Li-Yang, Loomba-Chlebicka, Nidhi, Koh, Tse-Hsien, Kang, Mei-Ling, Tan, Ban-Hock, and Tambyah, Paul Ananth

Subjects
Staphylococcus aureus, methicillin resistance, bacteremia, bacterial infections and mycoses, outcomes, mortality, Article
Abstract

EMRSA-15 (ST22-MRSA-IV) is rapidly replacing the endemic ST239 health care-associated methicillin-resistant Staphylococcus aureus clone in Singapore. A one-year single-centre cohort study of inpatients with MRSA bacteremia was performed to determine if bacteremia caused by EMRSA-15 was associated with worse outcomes compared to bacteremia caused by the endemic ST239 strain. Strains were identified by antibiotypes, and subsequent validation was performed on a selected sample of MRSA strains via pulsed-field gel electrophoresis and staphylococcal chromosome cassette mec typing. Two hundred and twenty-eight patients with MRSA bacteremia were studied; Seventy-three were infected with EMRSA-15. EMRSA-15 and ST239-infected patients were similar regarding gender, frequencies of most co-morbidities, and risk factors for adverse outcomes. Similar numbers of EMRSA-15-infected and ST239-infected patients died (24.7% vs 27.1%, P=0.70) or developed complicated infections (41.1% vs 40.0%, P=0.88). After multivariate analysis, EMRSA-15 as a cause of bacteremia was not significantly associated with either death or development of complicated infections, although inappropriate therapy (5.45-fold, P

Published
2007

43. In Vitro Activity of Polymyxin B in Combination with Various Antibiotics against Extensively Drug-Resistant Enterobacter cloacae with Decreased Susceptibility to Polymyxin B

Author

Cai, Yiying, primary, Lim, Tze-Peng, additional, Teo, Jocelyn, additional, Sasikala, Suranthran, additional, Lee, Winnie, additional, Hong, Yanjun, additional, Chan, Eric Chun Yong, additional, Tan, Thean Yen, additional, Tan, Thuan-Tong, additional, Koh, Tse Hsien, additional, Hsu, Li Yang, additional, and Kwa, Andrea L., additional

Published
2016
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44. From Bench-Top to Bedside: A Prospective In Vitro Antibiotic Combination Testing (iACT) Service to Guide the Selection of Rationally Optimized Antimicrobial Combinations against Extensively Drug Resistant (XDR) Gram Negative Bacteria (GNB)

Author

Cai, Yiying, primary, Chua, Nathalie Grace, additional, Lim, Tze-Peng, additional, Teo, Jocelyn Qi-Min, additional, Lee, Winnie, additional, Kurup, Asok, additional, Koh, Tse-Hsien, additional, Tan, Thuan-Tong, additional, and Kwa, Andrea L., additional

Published
2016
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47. In Vitro Activities of Ceftazidime-Avibactam, Aztreonam-Avibactam, and a Panel of Older and Contemporary Antimicrobial Agents against Carbapenemase-Producing Gram-Negative Bacilli

Author

Vasoo, Shawn, primary, Cunningham, Scott A., additional, Cole, Nicolynn C., additional, Kohner, Peggy C., additional, Menon, Sanjay R., additional, Krause, Kevin M., additional, Harris, Kelly A., additional, De, Partha P., additional, Koh, Tse Hsien, additional, and Patel, Robin, additional

Published
2015
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