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3. Safety and efficacy of SNK01 (autologous natural killer cells) in combination with cytotoxic chemotherapy and/or cetuximab after failure of prior tyrosine kinase inhibitor in non-small cell lung cancer: non-clinical mouse model and phase I/IIa clinical study

Author

Choi, Myeong Geun, primary, Son, Gun Woo, additional, Choi, Mi Young, additional, Jung, Jae Seob, additional, Rho, Jin Kyung, additional, Ji, Wonjun, additional, Yoon, Byeong Gon, additional, Jo, Jong-Min, additional, Kim, Yong Man, additional, Ko, Dae-Hyun, additional, Lee, Jae Cheol, additional, and Choi, Chang-Min, additional

Published
2024
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10. A Phase I/IIa Randomized Trial Evaluating the Safety and Efficacy of SNK01 Plus Pembrolizumab in Patients with Stage IV Non-Small Cell Lung Cancer

Author

Kim, Eo Jin, primary, Cho, Yong-Hee, additional, Kim, Dong Ha, additional, Ko, Dae-Hyun, additional, Do, Eun-Ju, additional, Kim, Sang-Yeob, additional, Kim, Yong Man, additional, Jung, Jae Seob, additional, Kang, Yoonmi, additional, Ji, Wonjun, additional, Choi, Myeong Geun, additional, Lee, Jae Cheol, additional, Rho, Jin Kyung, additional, and Choi, Chang-Min, additional

Published
2022
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17. Outcome of ABO-Incompatible Kidney Transplantation According to ABO Type of Transfused Plasma: Comparative Analysis Between “Universal” AB and Donor-Type Plasma

Author

Kim, Han Joo, primary, Kim, Jin Seok, additional, Yang, John Jeongseok, additional, Chung, Yousun, additional, Kim, Hyungsuk, additional, Shin, Sung, additional, Kim, Young Hoon, additional, Hwang, Sang-Hyun, additional, Oh, Heung-Bum, additional, Han, Duck-Jong, additional, Kwon, Hyunwook, additional, and Ko, Dae-Hyun, additional

Published
2022
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24. Is Cryoprecipitate-Reduced Plasma an Efficacious Replacement Fluid for Therapeutic Plasma Exchange for Patients with Thrombotic Microangiopathy? A Single-Center Retrospective Experience.

Author

Kim, Han Joo, Yang, John Jeongseok, Kim, Hyungsuk, Hwang, Sang-Hyun, Oh, Heung-Bum, Chung, Yousun, and Ko, Dae-Hyun

Subjects
THROMBOCYTOPENIA treatment, PLASMA exchange (Therapeutics), RETROSPECTIVE studies, ACQUISITION of data, MANN Whitney U Test, TREATMENT effectiveness, COMPARATIVE studies, PLATELET count, LACTATE dehydrogenase, MEDICAL records, DATA analysis software, EVALUATION
Abstract

Objective We designed a study to compare the efficacy of cryoprecipitate-reduced plasma (CRP) and fresh frozen plasma (FFP), at the level of individual sessions, for treating refractory thrombotic microangiopathy (TMA) with therapeutic plasma exchange (TPE). Materials and Methods Platelet counts (× 10³/μL) and lactate dehydrogenase (LD; IU/L) levels were measured before and after each session. We compared the mean-percentage and absolute changes in platelet count and LD after each TPE session. Results The data from 33 patients treated for TMA between 2009 and 2018 were collected for this study. Both absolute and percentage increases in the platelet count were statistically significant (P =.003 and P =.011, respectively) when CRP was used. However, when patients were divided into subgroups according to specific diagnosis, no significant differences were found among the groups, except in terms of the absolute platelet count increase in the thrombotic thrombocytopenic purpura group (P <.001). Conclusion The platelet count increase was higher when patients received CRP than when they received FFP. We found that CRP may be a rescue option for patients with refractory TMA. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Outcome of ABO-incompatible kidney transplantation depending on the ABO type of transfused plasma: comparative analysis between the universal AB plasma and donor type plasma

Author

Kim, Han Joo, primary, Kim, Jin Seok, additional, Yang, John Jeongseok, additional, Chung, Yousun, additional, Kim, Hyungsuk, additional, Shin, Sung, additional, Kim, Young Hoon, additional, Hwang, Sang-Hyun, additional, Oh, Heung-Bum, additional, and Ko, Dae-Hyun, additional

Published
2020
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37. Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn’s disease

Author

Oh, Eun Hye, primary, Ko, Dae-Hyun, additional, Seo, Hyungil, additional, Chang, Kiju, additional, Kim, Gwang-Un, additional, Song, Eun Mi, additional, Seo, Myeongsook, additional, Lee, Ho-Su, additional, Hwang, Sung Wook, additional, Yang, Dong-Hoon, additional, Ye, Byong Duk, additional, Byeon, Jeong-Sik, additional, Myung, Seung-Jae, additional, Yang, Suk-Kyun, additional, and Park, Sang Hyoung, additional

Published
2017
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40. Comparison of Thyroglobulin Measurements Using Three Different Immunoassay Kits: A BRAMHS Tg-Plus RIA Kit, a BRAMHS hTg Sensitive Kryptor Kit, and a Beckman Coulter ACCESS Immunoassay Kit

Author

Kim, Mijin, primary, Jeon, Min Ji, additional, Kim, Won Gu, additional, Lee, Jong Jin, additional, Ryu, Jin-Sook, additional, Cho, Eun-Jung, additional, Ko, Dae-Hyun, additional, Lee, Woochang, additional, Chun, Sail, additional, Min, Won-Ki, additional, Kim, Tae Yong, additional, Shong, Young Kee, additional, and Kim, Won Bae, additional

Published
2016
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41. A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction

Author

Ko, Dae-Hyun, Chang, Ho Eun, Kim, Taek Soo, Song, Eun Young, Park, Kyoung Un, Song, Junghan, and Han, Kyou Sup

Subjects
Article Subject, polycyclic compounds, food and beverages, skin and connective tissue diseases
Abstract

Haptoglobin, the product of the gene, is a glycoprotein involved in the scavenging of free hemoglobin. Haptoglobin levels increase or decrease in response to various acquired conditions, and they are also influenced by genetic predisposition. There were 2 major alleles, and , and 1 minor allele, . Many researchers have attempted to study the haptoglobin types and their association with disease; however, no definitive conclusions have been reached yet. It is reported that patients who are genetically deficient in haptoglobin are at risk of anaphylaxis against blood components containing haptoglobin. Haptoglobin genotypes also affect the reference intervals of haptoglobin levels. Many studies have attempted to establish simple and accurate typing methods. In this paper, we have broadly reviewed several methods for haptoglobin typing—phenotyping, Southern blotting, conventional PCR, real-time PCR, and loop-mediated isothermal amplification. We discuss their characteristics, clinical applications, and limitations. The phenotyping methods are time consuming and labor intensive and not designed to detect patients harboring . The rapid and robust haptoglobin genotyping may help in preventing fatal anaphylactic reactions and in establishing the relationships between the haptoglobin phenotypes and diseases.

Published
2013
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47. Influence of Vitamin C on Urine Dipstick Test Results.

Author

Ko DH, Jeong TD, Kim S, Chung HJ, Lee W, Chun S, and Min WK

Subjects
Administration, Oral, Dose-Response Relationship, Drug, False Positive Reactions, Female, Healthy Volunteers, Humans, Leukocytes drug effects, Male, Ascorbic Acid administration & dosage, Ascorbic Acid urine, Reagent Strips
Abstract

Background: Vitamin C is a strong reducing agent found at high levels in various foods, and it may influence the results of urine strip tests even at an ordinary consumption levels. After oral administration, we measured urine vitamin C levels using urine strips and evaluated whether vitamin C interfered with various test items. The utility of a urine strip with a vitamin C indicator was assessed., Methods: Thirty-three healthy volunteers each ingested 1,000 mg of vitamin C. Their urine samples were tested for vitamin C using a URiSCAN 11 strip (YD Diagnostics, Korea) before and after administration of vitamin C. Standard materials were added to normal pooled urine to generate urine samples with various concentrations of the analytes tested (blood, bilirubin, nitrite, leukocytes, and glucose), and vitamin C was spiked to predetermined levels. These samples were then tested using two urine strips - URiSCAN and Chemstrip test strip (Roche Diagnostics, Germany) - to evaluate interference from vitamin C. In clinical samples with positive vitamin C results, microscopic and chemical analyses were also conducted to examine the differences., Results: Thirteen urine samples from the 33 volunteers were positive for vitamin C before ingestion, and all subjects were positive after ingestion. Vitamin C spiking of urine demonstrated false-negative results at various concentrations. Of 159 specimens with positive results for vitamin C, 14 showed discrepant results after additional confirmatory tests., Conclusions: Vitamin C in urine can cause significant interference with urine strip tests. A urine strip with a vitamin C indicator is useful to reduce the risk of incorrect results in regard to disease states., (© 2015 by the Association of Clinical Scientists, Inc.)

Published
2015

48. Novel GALT variations and mutation spectrum in the Korean population with decreased galactose-1-phosphate uridyltransferase activity.

Author

Choi R, Jo KI, Ko DH, Lee DH, Song J, Jin DK, Ki CS, Lee SY, Kim JW, Lee YW, and Park HD

Subjects
Asian People genetics, Exons, Female, Frameshift Mutation, Genetic Variation, Humans, INDEL Mutation, Infant, Male, Mutation, Missense, RNA Splicing, Sequence Analysis, DNA, Galactosemias genetics, Mutation, UTP-Hexose-1-Phosphate Uridylyltransferase genetics
Abstract

Background: Classic galactosemia (OMIM #230400) is an autosomal recessive metabolic disorder caused by a deficiency of the galactose-1-phosphate uridyltransferase (GALT, EC2.7.7.12) protein due to mutations in the GALT gene. The aim of this study was to provide a comprehensive and updated mutation spectrum of GALT in a Korean population., Methods: Thirteen unrelated patients screened positive for galactosemia in a newborn screening program were included in this study. They showed a reduced GALT enzyme activity in red blood cells. Direct sequencing of the GALT gene and in silico analyses were done to evaluate the impact of novel variations upon GALT enzyme activity. We also reviewed previous reports for GALT mutations in Koreans., Results: We identified six novel likely pathogenic variations including three missense (p.Ala101Asp, p.Tyr165His, and p.Pro257Thr), one small deletion/insertion [c.826&#95;827delinsAA (p.Ala276Asn)], one frameshift (p.Asn96Serfs*5), and one splicing (c.378-1G > C) likely pathogenic variations. The most frequent variation was the Duarte variant (c.940A > G, 35.3%), followed by c.507G > C (p.Gln169His, 9.6%), among 34 Korean patients. Other mutations were widely scattered. None of the eight common mutations used for targeted mutation analysis in Western countries including p.Gln188Arg, p.Ser135Leu, p.Lys285Asn, p.Leu195Pro, p.Tyr209Cys, p.Phe171Ser, c.253-2A > G, and a 5 kb deletion, had been found in Koreans until this study., Conclusions: Considering the mutation spectrum in Koreans, direct sequence analysis of entire GALT exons is recommended for accurate diagnosis. The mutations responsible for GALT deficiency in the Korean population were clearly different from those of other populations.

Published
2014
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49. Identification of compound heterozygous mutation in a Korean patient with alpha 1-antitrypsin deficiency.

Author

Ko DH, Chang HE, Song SH, Yoon H, Park KU, and Song J

Subjects
Adult, Base Sequence, Exons, Female, Frameshift Mutation, Heterozygote, Humans, Mutation, Missense, Pedigree, Pulmonary Emphysema diagnosis, Pulmonary Emphysema diagnostic imaging, Republic of Korea, Sequence Analysis, DNA, Tomography, X-Ray Computed, alpha 1-Antitrypsin genetics, alpha 1-Antitrypsin Deficiency diagnosis, alpha 1-Antitrypsin Deficiency diagnostic imaging, Asian People genetics, alpha 1-Antitrypsin Deficiency genetics
Abstract

Alpha 1-antitrypsin (AAT) deficiency is a genetic disorder that primarily affects the lungs and liver. While AAT deficiency is one of the most common genetic disorders in the Caucasian population, it is extremely rare in Asians. Here, we report the case of a 36-year-old Korean woman with AAT deficiency who visited the emergency department of our hospital for the treatment of progressive dyspnea that had begun 10 years ago. She had never smoked. Chest computed tomography revealed panlobular emphysema in both lungs, which suggested AAT deficiency. The serum AAT level was 33 mg/dL (reference interval: 90-200 mg/dL). Four exons of the SERPINA1 gene, which is responsible for AAT deficiency, and their flanking regions were analyzed by PCR-direct sequencing. The patient was found to have 1 missense mutation (c.230C>T, p.Ser77Phe; S(iiyama)) and 1 frameshift mutation (c.1158dupC, p.Glu387ArgfsX14; QO(clayton)). This is the first Korean case of AAT deficiency confirmed by genetic analysis and the second case of a compound heterozygote of S(iiyama) and QO(clayton), the first case of which was reported from Japan.

Published
2011
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50. [Discrepancies between human leukocyte antigen registry typing and confirmatory typing results of unrelated hematopoietic stem cell donors].

Author

Ko DH, Chung HY, Lim YM, Han BY, Song EY, and Park MH

Subjects
Diagnostic Errors statistics & numerical data, Hematopoietic Stem Cells metabolism, Humans, Tissue Donors, HLA Antigens genetics, Hematopoietic Stem Cell Transplantation, Histocompatibility Testing methods, Registries
Abstract

Background: In unrelated hematopoietic stem cell transplantation, the accuracy of HLA registry typing (RT) of donors is important for timely search and coordination of HLA-matched donors. We analyzed discrepancies between HLA RT and confirmatory typing (CT) results of stem cell donors in Korean and foreign registries., Methods: We analyzed the HLA typing results of 834 donors for whom CT was performed at Seoul National University Hospital between April 1997 and March 2010. For CT, DNA typing was used in majority of the cases and HLA-A and HLA-B serological typing was used in some early cases. The discrepancies between the typing results were analyzed at the serological/generic level., Results: The overall discrepancy rate (RT error rate) was 3.2%, and the rate was similar in the Korean and foreign registries. The discrepancy rates in the Korean and foreign registries were more than 10% in the 1997-2001 searches, but decreased to less than 3% in the 2002-2010 searches. Analysis of 19 cases of RT errors in the Korean registry revealed 3 cases of sample switchover errors and 16 cases of typing errors in one of the HLA-A, HLA-B, or HLA-DR loci. The RT error rate in Japan Marrow Donor Program was lower than those in other foreign registries., Conclusions: The error rate of HLA RT results of unrelated stem cell donors in the Korean registry was similar to those in the foreign registries, and has decreased in the recent searches following the change in the typing method from serological to DNA typing.

Published
2010
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