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Objective: Research comparing patients who received liver transplantation (LT) for hepatocellular carcinoma (HCC) has produced varying outcomes regarding survival and disease-free survival. The objective of this study is to determine the factors that influence the disease-free and overall survivals of those who have undergone LT for HCC and to compare the outcomes of living versus deceased donor liver transplants. Materials and Methods: We retrospectively analyzed data on patients aged 18 and above who received LT for HCC from 2006 to 2022. Patients with a follow-up period of less than 6 months and who did not meet the University of California San Francisco criteria were excluded. The data from 58 patients were analyzed. We split the patients into living donor liver transplantation (LDLT) (group 1) and deceased donor liver transplantation (DDLT) (group 2). Results: The mean age was 56 ± 8.1 years. There were 49 males and 9 females. The median of the alphafetoprotein (AFP) level and model for end-stage liver disease score was 10.1 ng/mL and 11, respectively. The 1-, 3-, 5-, and 10-year disease-free survival rates were 86%, 76.5%, 76.5%, and 76.5%, respectively. The survival rates for the same periods were 94.8%, 74.9%, 70.6%, and 67.4%. The receiver operating characteristic analysis revealed that AFP > 31.8 ng/mL and a total tumor size >3.85 cm raise the likelihood of HCC recurrence post-LT. Conclusion: Based on the current literature, the overall survival and disease-free survival rates are influenced by factors such as AFP value, total tumor number, and total tumor diameter. In our study, the AFP value and total tumor size had an impact on the recurrence of HCC, and the survival rates were comparable on LDLT and DDLT. [ABSTRACT FROM AUTHOR]

Duodenal diverticula (DD) are classified as primary (true) or secondary (false) diverticula. Primary diverticula are mostly solitary and can be observed in the second part of the duodenum, in the [...], Background: Previous studies have evaluated the presence of juxtapapillary duodenal diverticula (JPDD) and the association with pancreatobiliary disease, but not the association of the papilla with an existing JPDD. We investigated the association of different localizations of the papilla with JPDD. Methods: We studied patients in whom JPDD was detected during endoscopic retrograde cholangiopancreatography. Patients were classified into 3 groups: 1) papilla located inside the diverticulum, 2) papilla located at the edge of the diverticulum and 3) papilla located closer than 3 cm to the diverticulum. The patients were examined with respect to localization of papilla--diverticula and to the association of the localization with pancreaticobiliary disease. Results: We enrolled 274 patients in our study. Biliary stone disease more frequently existed in group 3. The number of patients presenting with obstructive jaundice was higher in groups 2 (83.6%) and 3 (83.3%) than group 1 (66%). Cholangitis was more common in group 1 (21.3%) than in groups 2 (6.7%) and 3 (2.3%). The presence of biliary stone disease among patients presenting with pancreatitis was significantly different between groups 1 and 3 (p = 0.013) and between groups 2 and 3 (p = 0.017). The common bile duct more frequently contained stones or sludge in group 3 than in groups 1 and 2. Conclusion: When the papilla is located close to the JPDD, the incidence of biliary stone disease decreases, and pancreatobiliary diseases are caused mostly in the absence of biliary stone disease. Contexte : Des etudes anterieures ont evalue la presence de diverticules duodenaux juxtapapillaires (DDJP) et leur lien avec la maladie pancreatobiliaire, mais n'ont pas analyse le lien entre la papille et les DDJP existants. Nous avons analyse le lien entre diverses localisations de la papille et les DDJP. Methodes : Nous avons etudie des patients chez qui des DDJP ont ete detectes lors d'une cholangiopancreatographie endoscopique retrograde. Les patients ont ete classes en 3 groupes : 1) papille a l'interieur du diverticule, 2) papille a l'extremite du diverticule et 3) papille a moins de 3 cm du diverticule. L'examen a donc porte sur la localisation de la papille par rapport aux diverticules et sur le lien entre sa localisation et la maladie pancreatobiliaire. Resultats : Nous avons inscrit 274 patients a notre etude. La cholelithiase s'observait davantage dans le groupe 3. Le nombre de patients souffrant d'ictere obstructif etait plus eleve dans les groupes 2 (83,6 %) et 3 (83,3 %) que dans le groupe 1 (66 %). La cholangite etait plus frequente dans le groupe 1 (21,3 %) que dans les groupes 2 (6,7 %) et 3 (2,3 %). Le taux de cholelithiase chez les patients souffrant de pancreatite etait significativement different entre les groupes 1 et 3 (p = 0,013) et entre les groupes 2 et 3 (p = 0,017). Il y avait plus de calculs ou de boue biliaires dans le canal choledoque des patients du groupe 3 que dans ceux des groupes 1 et 2. Conclusion : Lorsque la papille est situee pres des DDJP, l'incidence de la cholelithiase diminue, et les maladies pancreatobiliaires sont pour la plupart causees en l'absence de cholelithiase.

It is known that emergency surgery for colon cancer is associated with high morbidity and mortality. We retrospectively evaluated colon cancer patients admitted with perforation. The total 223 patients who had colon cancer, 74 (33%) underwent emergent colon surgery and 34 (15%) of them had perforation. Median age was 60.65±10.06 years (range:39-79 years) and 12 patients were female (35%). The most common tumor localization was in sigmoid colon (41%). Perforation site was proximal to the tumor in 26 cases (76.5%) and at the tumor site in 8 (23.5%). Peritonitis was present in 28 patients (82%). One of the major complications was anastomotic dehiscence (6 patients, 17.6%). The mortality rate was 29.4% (10 patients) and the morbidity rate was 47.1% (16 patients). The mortality of perforated colon cancer cases is high. Factors associated with mortality are left sided colon tumors (p=0.006), ASA score > 2 (p=0.01), the presence of liver metastasis (p=0.005) and the presence of >25 index according to Mannheim peritonitis index (p=0.002). [ABSTRACT FROM AUTHOR]

To evaluate the effectiveness of serum levels of resistin and CD14 expression in monocytes, and high-sensitivity C-reactive protein (hsCRP) in early stages of acute pancreatitis and correct prediction of the severity of acute pancreatitis (AP) using scoring systems. The study involved 10 (29.41%) male and 24 (70.59%) female patients (total n=34) followed for AP diagnosis at the Department of General Surgery, Ataturk University Medical School between July 2008 and September 2009. In all the patients, Ranson and APACHE II scores, serum resistin, hsCRP, and monocyte CD14 expression levels were determined. The patients were divided into two groups as mild and severe AP groups. A control group was formed and the intergroup comparisons were made. Values ≥ 3 based on the Ranson scoring scale and values ≥ 8 in APACHE II scoring scale were considered to indicate severe AP. Evaluations were based on the values obtained on the 1st and 7th days for serum resistin and hsCRP levels and monocyte CD 14 expression. In 17 (50%) patients, severe AP was determined. No statistically significant differences were found between the mean serum resistin levels of AP groups, while the difference for the same parameter between the mild and severe AP groups and the control group was statistically significant. In the severe AP group, the mean 1 day and 7 day serum hsCRP levels were statistically significantly higher. The CD14 expression in monocytes was similar in all the groups. Serum hsCRP concentrations and Ranson and APACHE II scores and serum resistin and hsCRP concentrations on the 1 day were positively correlated. Serum hsCRP measurement is effective in determining the severity of acute pancreatitis. Serum resistin measurement may be a useful early marker in determining the inflammatory response in AP. However, CD14 expression in monocytes was not found to be a useful marker in the diagnosis and prediction of the disease severity in AP patients. [ABSTRACT FROM AUTHOR]