Search

In the majority of domestic firms physical distribution functions are usually considered to sales. Thus, it is supposed that essential difference between advertising and marketing operations is not available. The marketing logistics as the mechanism of the marketing channel control is concentrated on integration of marketing and logistics functions while maintaining the great value of products and services. In order to evaluate the marketing logistics effectiveness, it is possible to use the concept of “perfect order”. Most companies produce marketing logistics on a functional basis. In its evolution and functional organization of logistics went through three key periods. The first period is characterized by the distribution of logistics functions among the three most major areas of activity: finance, production, and marketing. The second period is characterized by the release of physical distribution functions in an independent direction. Marketing began to implement forecasting sales of finished products, and all other features already belong to physical distribution. It is worth noting that in the second period, the physical distribution of gains recognized on the financing, production and marketing. The third period is characterized by a large extent for the integrated logistics. It is best formed, and in line with market demands structural construction. Also during this period clearly stood out the strategic and operational levels of decision-making. The CEO and the director of logistics make strategic decisions.

This article presents the study results of the business intelligence markets, the promote products on social media, and a new method for increasing the information pertinence in the scientific recommender systems, scientific information systems, analysis of the recommender systems that contain information about scientific publications, is represented. The prospects of using this method in the Business Intelligence systems, content management systems for native advertising systems to find content on the Internet and assessed the current state of the market such systems.

Innovations are means of competition. A success in how an enterprise uses the innovation processes directly depends on its competitive ability and profitability level. Innovation performance is a level of using innovations. Under a competitive struggle in the market, progress in science and technology holds a specific place. Innovations define the economic success of an organization. It is not simple to have only a desire to increase the performance results, it is necessary to have a factor for organization survival, competitive ability and economic growth prospects preservation throughout the modern innovation world. The experience of the most developed countries shows that the one, whose activity is mainly based on using the innovation processes, becomes a winner in a fight for his client and the main purpose of organizations’ strategic plan is to develop either a new product or services. The innovation performance of an enterprise can become one of the main factors for organizing the competitive strategic prospects of an enterprise, preserving and increasing its positions in the market. The topicality of the theme is very high, as introducing innovations in the activity of an enterprise and its competitive ability level in the market depend on the level of an organization’s innovation performance.

The article based on the analysis of the literature and experience in the field of economic education is considered a system of key concepts on the topic, as well as features of the introduction of competence approach in teaching practice Polytechnic Institute, the problem of realization competence approach in higher education, the formation of key information technology competencies, ensuring high availability Polytechnic Institute graduates to solve problems in the practice of the specialty, modern requirements to the society and the state system of vocational education at all levels, the task of creating these pedagogical conditions, which would help improve the quality of training of future specialists. This article lists didactic, psycho-pedagogical, organizational and pedagogical conditions that are necessary to improve the level of information technology training of future specialists. Their implementation will create the necessary information technology economist competence.

Twenty-nine Amaryllidaceae alkaloids and their derivatives belonging to the five most common groups, including lycorine, lycorenine, tazettine, crinine, and narciclasine types, were evaluated for antiproliferative, apoptosis-inducing, and anti-invasive activities in vitro. The antiproliferative properties of each test compound are in agreement with those reported in the literature, while the high potency of amarbellisine is reported for the first time. It was also found that with the exception of ungeremine, amarbellisine, and hippeastrine, the antiproliferative effect of the potent compounds is apoptosis mediated. Thus, apoptosis in Jurkat cells was triggered by narciclasine, narciclasine tetraacetate, C10b-R-hydroxypancratistatin, cis-dihydronarciclasine, trans-dihydronarciclasine, lycorine, 1-O-acetyllycorine, lycorine-2-one, pseudolycorine, and haemanthamine. With the exception of narciclasine, lycorine, and haemanthamine, the apoptosis-inducing properties of these compounds are reported for the first time. The collagen type I invasion assay revealed potent anti-invasive properties associated with N-methyllycorine iodide, hippeastrine, clivimine, buphanamine, and narciclasine tetraacetate, all of which were tested at non-toxic concentrations. The anti-invasive activity of buphanamine is particularly promising because this alkaloid is not toxic to cells even at much higher doses. This work has resulted in the identification of several novel leads for anticancer drug design.