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1. 1359 NTX-0471, engineered multivalent SIRPa and bispecific SIRPa-antiCCR4 molecules demonstrate superior activity providing path for mRNA expressed in-vivo biologics

Author: Weiqun Liu, Meredith Leong, Evan McCartney-Melstad, Colin McKinlay, Adrienne Sallets, Samuel Deutsch, Gunasekaran Kannan, Gowrisudha Adusumilli, Srinivasa Bandi, Shruti Lal, Ray Low, Ole Audun Haabeth, Pei-Ken Hsu, Kimmy Ferry, Anustha Sharma, and Jenna Triplett
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2023
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2. Psikoedukasi Sebagai Upaya Meningkatkan Pemahaman Kesiapan Perkawinan Bagi Remaja

Author: Martha Kurnia Asih, Shinta Pratiwi, Retno Ristiasih Utami, and Kimmy Katkar
Subjects: psychoeducation, marriage readiness, youth., Social Sciences, Science
Abstract: This service activity aims to increase the youth's understanding of the importance of resilience, including physical, psychological, and financial readiness. This service was implemented in psychoeducation with the target students in Kesatrian 2 Semarang Senior High School. This service instrument used a questionnaire and was analyzed by pretest and post-test. Based on the analysis using the Paired Sample T-Test, it was concluded that there was an increase of 14.31 with a mean pretest difference score of 72.54 and 86.81 post-test. It showed an increased understanding of adolescent marriage readiness after being given psychoeducation. The activities benefit adolescents with advanced knowledge of marriage readiness, including physical, psychological, and financial readiness.
Published: 2023
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3. Do cognition and emotion matter? A study of COVID-19 vaccination decision-making in college students

Author: Nien-Tsu Nancy Chen, Kimmy Kee, Bianca T Villalobos, Miriam Ortiz, and HyeSun Lee
Subjects: Psychology, BF1-990
Abstract: The unparalleled speed of COVID-19 vaccine development has necessitated an expansion of existing knowledge on vaccination decision-making. The current study explored (1) how cognitions and emotions shaped college students’ COVID-19 vaccination decisions, and (2) where vaccination-inclined and vaccination-hesitant students converged and diverged in their decision-making process. Seventy-seven students participated in 26 focus groups to discuss their complex thoughts and feelings regarding COVID-19 vaccination, offering a more nuanced understanding of COVID-19 vaccination decision-making that has not been fully captured by quantitative studies. Thematic analysis found that vaccination-inclined participants and their hesitant counterparts reported differential patterns of positive and negative emotions, systematic appraisals, and heuristics in decision-making. Future research should investigate the roles of hope and relief, non-health-related benefits of vaccination, social trust, and interpersonal influence in vaccination decision-making.
Published: 2023
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4. Transtorno do Espectro Autista infantil e os desafios familiares: revisão integrativa de literatura

Author: João Victor de Almeida Farias, Kimmy Amâncio Silva Silva, Maiara Maria da Silva, Noemi Thomé Mendes, Rita Maria Santos Lima, Thalia Lima da Silva, Monique Carla da Silva, and Mara Cristina Ribeiro
Subjects: TEA, Diagnóstico, Relações familiares, Education, Science, Social Sciences
Abstract: O autismo infantil envolve alterações significativas nas áreas de socialização, cognição e comunicação, com quadros, muitas vezes persistentes e severos. Estes têm uma grande variação individual e exigem, com muita frequência, cuidados intensos por parte dos pais ou familiares, longos e permanentes períodos de dedicação integral. O estudo teve por objetivo investigar na literatura os desafios encontrados no cotidiano de famílias de crianças com TEA. Trata-se de uma revisão integrativa de literatura que utilizou as bases de dados SCIELO, LILACS e Google Acadêmico para a coleta dos dados. Por meio dos Descritores em Ciências da Saúde foram utilizados para a busca os termos “Transtorno do Espectro Autista”, “Diagnóstico" e Relações Familiares'', sendo que o primeiro termo foi cruzado com os demais. Os critérios de inclusão foram artigos na íntegra, publicados nas línguas portuguesa, inglesa e espanhola, nos últimos quatro anos (2018 a 2022). A primeira busca registrou um achado de 115 artigos na base de dados LILACS e 22 artigos na base de dados SCIELO e 95 artigos no Google Acadêmico. Após a aplicação dos critérios de inclusão e exclusão, chegou-se a um total de 9 artigos. Observou-se a partir das literaturas incluídas nesta revisão que o TEA pode afetar significativamente a rotina da família, devido ao aumento das dificuldades e incertezas que a família passa a ter após o diagnóstico. Considerando o impacto que as famílias vivenciam, é preciso que as dificuldades das mesmas sejam trabalhadas através de uma atenção especializada.
Published: 2023
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5. Pelatihan Resiliensi pada Remaja Panti Asuhan

Author: Kimmy Katkar, Purwaningtyastuti Pungky, and Retno Ristiasih Utami
Subjects: youth, resilience, Social Sciences
Abstract: Adolescents who live in orphanages will only have their physiological needs met but not their psychological needs, this is because the condition of the orphanage with the number of caregivers and orphans that are not comparable can cause psychological problems. The lack of guidance from caregivers in more depth can be one of the triggering factors for adolescents who live in orphanages when experiencing problems in their lives to be more susceptible to stress, pressure and depression. This makes it easy for individuals to fall and find it difficult to get back up. The implementation method in this service activity is carried out offline by giving lectures, case studies and games. Activities were evaluated using the pretest and post-test measurement models. Based on the results of the analysis using the Paired Sample T-Test, it was found that there was an increase of 17.98 with a difference in the mean score of pretest 56.95 and post-test 74.93. This shows an increase in resilience in orphaned adolescents after being given training. The activities that have been carried out are very useful for adolescents by increasing resilience and gaining new knowledge which before this activity teenagers did not know the meaning and importance of individuals having high resilience.
Published: 2021
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6. Predicting Punctuation in Ancient Chinese Texts: A Multi-Layered LSTM and Attention-Based Approach

Author: Cai, Tracy, Chang, Kimmy, and Nabi, Fahad
Subjects: Computer Science - Computation and Language
Abstract: It was only until the 20th century when the Chinese language began using punctuation. In fact, many ancient Chinese texts contain thousands of lines with no distinct punctuation marks or delimiters in sight. The lack of punctuation in such texts makes it difficult for humans to identify when there pauses or breaks between particular phrases and understand the semantic meaning of the written text (Mogahed, 2012). As a result, unless one was educated in the ancient time period, many readers of ancient Chinese would have significantly different interpretations of the texts. We propose an approach to predict the location (and type) of punctuation in ancient Chinese texts that extends the work of Oh et al (2017) by leveraging a bidirectional multi-layered LSTM with a multi-head attention mechanism as inspired by Luong et al.'s (2015) discussion of attention-based architectures. We find that the use of multi-layered LSTMs and multi-head attention significantly outperforms RNNs that don't incorporate such components when evaluating ancient Chinese texts.
Published: 2024

7. Ontology for Voice, Instruments, and Ensembles (OnVIE): Revisiting the Medium of Performance Concept for Enhanced Discoverability

Author: Kimmy Szeto
Subjects: Bibliography. Library science. Information resources
Abstract: Medium of performance—instruments, voices, and devices—is a frequent starting point in library users’ search for music resources. However, content and encoding standards for library cataloging have not been developed in a way that enables clear and consistent recording of medium of performance information. Consequently, unless specially configured, library discovery systems do not display medium of performance or provide this access point. Despite efforts to address this issue in the past decade in RDA, MARC, and the linked data environment, medium of performance information continues to be imprecise, dispersed across multiple fields or properties, and implied in other data elements. This article proposes revised definitions for “part,” “medium,” “performer,” and “ensemble,” along with a linked data model, the Ontology for Voice, Instruments, and Ensembles (OnVIE), that captures precise and complete medium of performance data reflecting music compositional practices, performance practices, and publishing conventions. The result is an independent medium of performance framework for recording searchable and machine-actionable metadata that can be hooked on to established library metadata ontologies and is widely applicable to printed and recorded classical, popular, jazz, and folk music. The clarity, simplicity, and extensibility of this model enable machine parsing so that the data can be searched, filtered, sorted, and displayed in multiple, creative ways.
Published: 2022

8. Plant–plant interactions change during succession on nurse logs in a northern temperate rainforest

Author: Carrie L. Woods, Katy Maleta, and Kimmy Ortmann
Subjects: determinants of plant community structure, moss, nurse log, Olympic rainforest, plant–plant interactions, Stress Gradient Hypothesis, Ecology, QH540-549.5
Abstract: Abstract Plant–plant interactions change through succession from facilitative to competitive. At early stages of succession, early‐colonizing plants can increase the survival and reproductive output of other plants by ameliorating disturbance and stressful conditions. At later stages of succession, plant interactions are more competitive as plants put more energy toward growth and reproduction. In northern temperate rainforests, gap dynamics result in tree falls that facilitate tree regeneration (nurse logs) and bryophyte succession. How bryophyte‐tree seedling interactions vary through log succession remains unclear. We examined the relationships of tree seedlings, bryophyte community composition, bryophyte depth, and percent canopy cover in 166 1.0 m2 plots on nurse logs and the forest floor in the Hoh rainforest in Washington, USA, to test the hypothesis that bryophyte‐tree seedling interactions change from facilitative to competitive as the log decays. Tree seedling density was highest on young logs with early‐colonizing bryophyte species (e.g., Rhizomnium glabrescens) and lowest on decayed logs with Hylocomium splendens, a long‐lived moss that reaches depths >20 cm. As a result, bryophyte depth increased with nurse log decay and was negatively associated with tree seedling density. Tree seedling density was 4.6× higher on nurse logs than on the forest floor, which was likely due to competitive exclusion by forest floor plants, such as H. splendens. Nurse logs had 17 species of bryophytes while the forest floor had six, indicating that nurse logs contribute to maintaining bryophyte diversity. Nurse logs enable both tree seedlings and smaller bryophyte species to avoid competition with forest floor plants, including the dominant bryophyte, H. splendens. H. splendens is likely a widespread driver of plant community structure given its dominance in northern temperate forests. Our findings indicate that plant–plant interactions shift with succession on nurse logs from facilitative to competitive and, thus, influence forest community structure and dynamics.
Published: 2021
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9. Collagen Matrices Mediate Glioma Cell Migration Induced by an Electrical Signal

Author: Li Yao, Kimmy Tran, and Diana Nguyen
Subjects: collagen, migration, electric field, glioma, astrocyte, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65
Abstract: Glioma cells produce an increased amount of collagen compared with normal astrocytes. The increasing amount of collagen in the extracellular matrix (ECM) modulates the matrix structure and the mechanical properties of the microenvironment, thereby regulating tumor cell invasion. Although the regulation of tumor cell invasion mainly relies on cell–ECM interaction, the electrotaxis of tumor cells has attracted great research interest. The growth of glioma cells in a three-dimensional (3D) collagen hydrogel creates a relevant tumor physiological condition for the study of tumor cell invasion. In this study, we tested the migration of human glioma cells, fetal astrocytes, and adult astrocytes in a 3D collagen matrix with different collagen concentrations. We report that all three types of cells demonstrated higher motility in a low concentration of collagen hydrogel (3 mg/mL and 5 mg/mL) than in a high concentration of collagen hydrogel (10 mg/mL). We further show that human glioma cells grown in collagen hydrogels responded to direct current electric field (dcEF) stimulation and migrated to the anodal pole. The tumor cells altered their morphology in the gels to adapt to the anodal migration. The directedness of anodal migration shows a field strength-dependent response. EF stimulation increased the migration speed of tumor cells. This study implicates the potential role of an dcEF in glioma invasion and as a target of treatment.
Published: 2022
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10. Stealth dark matter spectrum using LapH and Irreps

Author: Brower, Richard C., Culver, Christopher, Cushman, Kimmy K., Fleming, George T., Hasenfratz, Anna, Howarth, Dean, Ingoldby, James, Jin, Xiao Yong, Kribs, Graham D., Meyer, Aaron S., Neil, Ethan T., Osborn, James C., Owen, Evan, Park, Sungwoo, Rebbi, Claudio, Rinaldi, Enrico, Schaich, David, Vranas, Pavlos, Weinberg, Evan, and Witzel, Oliver
Subjects: High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract: We present non-perturbative lattice calculations of the low-lying meson and baryon spectrum of the SU(4) gauge theory with fundamental fermion constituents. This theory is one instance of stealth dark matter, a class of strongly coupled theories, where the lowest mass stable baryon is the dark matter candidate. This work constitutes the first milestone in the program to study stealth dark matter self-interactions. Here, we focus on reducing excited state contamination in the single baryon channel by applying the Laplacian Heaviside method, as well as projecting our baryon operators onto the irreducible representations of the octahedral group. We compare our resulting spectrum to previous work involving Gaussian smeared non-projected operators and find good agreement with reduced statistical uncertainties. We also present the spectrum of the low-lying odd-parity baryons for the first time., Comment: 19 pages, 9 figures
Published: 2023

11. A Whole-Transcriptome Approach to Evaluating Reference Genes for Quantitative Gene Expression Studies: A Case Study in Mimulus

Author: Kimmy A. Stanton, Patrick P. Edger, Joshua R. Puzey, Taliesin Kinser, Philip Cheng, Daniel M. Vernon, Nancy R. Forsthoefel, and Arielle M. Cooley
Subjects: expression stability, Mimulus guttatus, Mimulus luteus, quantitative RT-PCR, RNA-seq, Genetics, QH426-470
Abstract: While quantitative PCR (qPCR) is widely recognized as being among the most accurate methods for quantifying gene expression, it is highly dependent on the use of reliable, stably expressed reference genes. With the increased availability of high-throughput methods for measuring gene expression, whole-transcriptome approaches may be increasingly utilized for reference gene selection and validation. In this study, RNA-seq was used to identify a set of novel qPCR reference genes and evaluate a panel of traditional “housekeeping” reference genes in two species of the evolutionary model plant genus Mimulus. More broadly, the methods proposed in this study can be used to harness the power of transcriptomes to identify appropriate reference genes for qPCR in any study organism, including emerging and nonmodel systems. We find that RNA-seq accurately estimates gene expression means in comparison to qPCR, and that expression means are robust to moderate environmental and genetic variation. However, measures of expression variability were only in agreement with qPCR for samples obtained from a shared environment. This result, along with transcriptome-wide comparisons, suggests that environmental changes have greater impacts on expression variability than on expression means. We discuss how this issue can be addressed through experimental design, and suggest that the ever-expanding pool of published transcriptomes represents a rich and low-cost resource for developing better reference genes for qPCR.
Published: 2017
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12. Myotonic Dystrophy and Anesthetic Challenges: A Case Report and Review

Author: Chanchal Mangla, Kimmy Bais, and Joel Yarmush
Subjects: Anesthesiology, RD78.3-87.3
Abstract: Providing anesthesia to patients with myotonic dystrophy (DM) can be very challenging due to the multisystemic effects of the disease and extreme sensitivity of these patients to sedatives, opioids, and anesthetic agents. Other factors such as hypothermia, shivering, or mechanical or electric stimulation during surgery can precipitate myotonia which is difficult to abolish and can lead to further complications. Generally, local or regional anesthesia is preferred to avoid the complications associated with general anesthesia in this group. However there are several case reports of successful use of general anesthesia (with or without volatile agents and with or without opioids). These general anesthetic cases led to postoperative admission to the regular floor or ICU. We present a case of a woman with a history of DM who underwent robotic assisted laparoscopic hysterectomy under general anesthesia and was discharged home on the same day.
Published: 2019
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13. Pairing up with anthropomorphized artificial agents: Leveraging employee creativity in service encounters

Author: Huang, Lexie Lan, Chen, Rocky Peng, and Chan, Kimmy Wa
Published: 2024
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14. Data Equity: Foundational Concepts for Generative AI

Author: Stonier, JoAnn, Woodman, Lauren, Alshammari, Majed, Cummings, Renée, Dad, Nighat, Garg, Arti, Busetto, Alberto Giovanni, Hsiao, Katherine, Hudson, Maui, Singh, Parminder Jeet, Kanamugire, David, Kapoor, Astha, Lei, Zheng, Lu, Jacqueline, Mizouni, Emna, Lungati, Angela Oduor, Loebel, María Paz Canales, Sethumadhavan, Arathi, Telford, Sarah, Sarin, Supheakmungkol, Bettinger, Kimmy, and Teeuwen, Stephanie
Subjects: Computer Science - Computers and Society
Abstract: This briefing paper focuses on data equity within foundation models, both in terms of the impact of Generative AI (genAI) on society and on the further development of genAI tools. GenAI promises immense potential to drive digital and social innovation, such as improving efficiency, enhancing creativity and augmenting existing data. GenAI has the potential to democratize access and usage of technologies. However, left unchecked, it could deepen inequities. With the advent of genAI significantly increasing the rate at which AI is deployed and developed, exploring frameworks for data equity is more urgent than ever. The goals of the briefing paper are threefold: to establish a shared vocabulary to facilitate collaboration and dialogue; to scope initial concerns to establish a framework for inquiry on which stakeholders can focus; and to shape future development of promising technologies. The paper represents a first step in exploring and promoting data equity in the context of genAI. The proposed definitions, framework and recommendations are intended to proactively shape the development of promising genAI technologies.
Published: 2023

15. Female and male patients’ perceptions of primary care doctors’ communication skills in Hong Kong

Author: Vivienne Leung and Kimmy Cheng
Subjects: patient experience, patient satisfaction, healthcare, communication, Medicine (General), R5-920, Public aspects of medicine, RA1-1270
Abstract: This study examined how female and male patients perceive primary doctors’ communication skills in the Chinese context. To do so, this study specifically investigates female and male patients’ general perceptions toward primary care doctors’ communication skills in medical consultations. Specifically, this study focused on (a) female and male patients’ satisfaction level toward primary care doctors’ communication skills in medical consultations (b) female and male patients’ perception of the types of verbal and nonverbal communication skills applied by primary care doctors in medical consultations (c) as well as which gender of doctors with whom patients prefer to communicate during primary care medical consultations in Hong Kong. A purposive sampling survey of Hong Kong residents aged 18 or older was conducted in April 2014. A total of 450 completed questionnaires were received. All respondents have visited a public hospital for outpatient service in the past 2 years. Results showed that there were no patient gender differences in patients’ perceptions of doctors’ communication skills, both female and male patient respondents showed a preference for same-gender doctors. Interestingly, in contrast with prior research, male patient respondents in this study revealed a stronger preference for doctors of the same gender than female patient respondents did. Other differences, such as cultural norms, values and practices, rather than just gender differences, may account for patients’ perceptions of doctors’ communication skills.
Published: 2016

16. Ruthenium-Based Catalytic Systems Incorporating a Labile Cyclooctadiene Ligand with N-Heterocyclic Carbene Precursors for the Atom-Economic Alcohol Amidation Using Amines

Author: Cheng Chen, Yang Miao, Kimmy De Winter, Hua-Jing Wang, Patrick Demeyere, Ye Yuan, and Francis Verpoort
Subjects: ruthenium (Ru), N-heterocyclic carbenes (NHCs), homogeneous catalysis, in situ, amide bonds, synthesis, Organic chemistry, QD241-441
Abstract: Transition-metal-catalyzed amide-bond formation from alcohols and amines is an atom-economic and eco-friendly route. Herein, we identified a highly active in situ N-heterocyclic carbene (NHC)/ruthenium (Ru) catalytic system for this amide synthesis. Various substrates, including sterically hindered ones, could be directly transformed into the corresponding amides with the catalyst loading as low as 0.25 mol.%. In this system, we replaced the p-cymene ligand of the Ru source with a relatively labile cyclooctadiene (cod) ligand so as to more efficiently obtain the corresponding poly-carbene Ru species. Expectedly, the weaker cod ligand could be more easily substituted with multiple mono-NHC ligands. Further high-resolution mass spectrometry (HRMS) analyses revealed that two tetra-carbene complexes were probably generated from the in situ catalytic system.
Published: 2018
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17. Snowmass Theory Frontier: Astrophysics and Cosmology

Author: Green, Daniel, Ruderman, Joshua T., Safdi, Benjamin R., Shelton, Jessie, Achúcarro, Ana, Adshead, Peter, Akrami, Yashar, Baryakhtar, Masha, Baumann, Daniel, Berlin, Asher, Blinov, Nikita, Boddy, Kimberly K., Buschmann, Malte, Cabass, Giovanni, Caldwell, Robert, Castorina, Emanuele, Chen, Thomas Y., Chen, Xingang, Coulton, William, Croon, Djuna, Cui, Yanou, Curtin, David, Cyr-Racine, Francis-Yan, Dessert, Christopher, Dienes, Keith R., Draper, Patrick, Du, Peizhi, Ellis, Sebastian A. R., Essig, Rouven, Flauger, Raphael, Fong, Chee Sheng, Foster, Joshua W., Fumagalli, Jacopo, Harigaya, Keisuke, Horiuchi, Shunsaku, Ivanov, Mikhail M., Kahn, Yonatan, Knapen, Simon, Leane, Rebecca K., Lee, Hayden, Lentz, Erik W., Lewandowski, Matthew, Lisanti, Mariangela, Long, Andrew J., Loverde, Marilena, Maleknejad, Azadeh, McAllister, Liam, McDermott, Samuel D., McGehee, Robert, Meerburg, P. Daniel, Meyers, Joel, Dizgah, Azadeh Moradinezhad, Münchmeyer, Moritz, Outmezguine, Nadav Joseph, Pajer, Enrico, Palma, Gonzalo A., Parikh, Aditya, Park, Jong-Chul, Peter, Annika H. G., Pimentel, Guilherme L., Renaux-Petel, Sébastien, Rodd, Nicholas L., Shakya, Bibhushan, Shiu, Gary, Silverstein, Eva, Simonovic, Marko, Singh, Rajeev, Sleight, Charlotte, Takhistov, Volodymyr, Tanedo, Philip, Taronna, Massimo, Thomas, Brooks, Toro, Natalia, Tsai, Yu-Dai, Vitagliano, Edoardo, Vogelsberger, Mark, Wallisch, Benjamin, Wandelt, Benjamin D., Wechsler, Risa H., Weniger, Christoph, Wu, W. L. Kimmy, Xu, Weishuang Linda, Yamada, Masaki, Yu, Hai-Bo, Zhang, Zhengkang, Zhong, Yi-Ming, and Zurek, Kathryn
Subjects: High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Theory
Abstract: We summarize progress made in theoretical astrophysics and cosmology over the past decade and areas of interest for the coming decade. This Report is prepared as the TF09 "Astrophysics and Cosmology" topical group summary for the Theory Frontier as part of the Snowmass 2021 process., Comment: 57 pages
Published: 2022

18. Lattice QCD and Particle Physics

Author: Kronfeld, Andreas S., Bhattacharya, Tanmoy, Blum, Thomas, Christ, Norman H., DeTar, Carleton, Detmold, William, Edwards, Robert, Hasenfratz, Anna, Lin, Huey-Wen, Mukherjee, Swagato, Orginos, Konstantinos, Brower, Richard, Cirigliano, Vincenzo, Davoudi, Zohreh, Jóo, Bálint, Jung, Chulwoo, Lehner, Christoph, Meinel, Stefan, Neil, Ethan T., Petreczky, Peter, Richards, David G., Bazavov, Alexei, Catterall, Simon, Dudek, Jozef J., El-Khadra, Aida X., Engelhardt, Michael, Fleming, George T., Giedt, Joel, Gupta, Rajan, Hansen, Maxwell T., Izubuchi, Taku, Karsch, Frithjof, Laiho, Jack, Liu, Keh-Fei, Meyer, Aaron S., Rinaldi, Enrico, Savage, Martin, Schaich, David, Shanahan, Phiala E., Sharpe, Stephen R., Sufian, Raza, Syritsyn, Sergey, Van de Water, Ruth S., Wagman, Michael L., Weinberg, Evan, Witzel, Oliver, Aubin, Christopher, Boyle, Peter, Chandrasekharan, Shailesh, Clöet, Ian C., Constantinou, Martha, Cushman, Kimmy, DeGrand, Thomas, Fodor, Zoltan, Foreman, Sam, Gottlieb, Steven, Hoying, Daniel, Jang, Yong-Chull, Jay, William I., Jin, Xiao-Yong, Kelly, Christopher, Kuti, Julius, Lamm, Henry, Lin, Meifeng, Lin, Yin, Lytle, Andrew T., Mackenzie, Paul, Mandula, Jeffrey, Meurice, Yannick, Monahan, Christopher, Morningstar, Colin, Osborn, James C., Park, Sungwoo, Simone, James N., Strelchenko, Alexei, Tomii, Masaaki, Vaquero, Alejandro, Vranas, Pavlos, Wang, Bigeng, Wilcox, Walter, Yoon, Boram, and Zhao, Yong
Subjects: High Energy Physics - Lattice, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: Contribution from the USQCD Collaboration to the Proceedings of the US Community Study on the Future of Particle Physics (Snowmass 2021)., Comment: 27 pp. main text, 4 pp. appendices, 29 pp. references, 1 p. index
Published: 2022

19. Forecasting ground-based sensitivity to the Rayleigh scattering of the CMB in the presence of astrophysical foregrounds

Author: Dibert, Karia R., Anderson, Adam J., Bender, Amy N., Benson, Bradford A., Bianchini, Federico, Carlstrom, John E., Crawford, Thomas M., Omori, Yuuki, Pan, Zhaodi, Raghunathan, Srinivasan, Reichardt, Christian L., and Wu, W. L. Kimmy
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Rayleigh scattering of cosmic microwave background (CMB) photons off the neutral hydrogen produced during recombination effectively creates an additional scattering surface after recombination that encodes new cosmological information, including the expansion and ionization history of the universe. A first detection of Rayleigh scattering is a tantalizing target for next-generation CMB experiments. We have developed a Rayleigh scattering forecasting pipeline that includes instrumental effects, atmospheric noise, and astrophysical foregrounds (e.g., Galactic dust, cosmic infrared background, or CIB, and the thermal Sunyaev-Zel'dovich effect). We forecast the Rayleigh scattering detection significance for several upcoming ground-based experiments, including SPT-3G+, Simons Observatory, CCAT-prime, and CMB-S4, and examine the limitations from atmospheric and astrophysical foregrounds as well as potential mitigation strategies. When combined with Planck data, we estimate that the ground-based experiments will detect Rayleigh scattering with a significance between 1.6 and 3.7, primarily limited by atmospheric noise and the CIB., Comment: 19 pages, 7 figures (v2 additional author added)
Published: 2022
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20. Snowmass2021 Cosmic Frontier: Cosmic Microwave Background Measurements White Paper

Author: Chang, Clarence L., Huffenberger, Kevin M., Benson, Bradford A., Bianchini, Federico, Chluba, Jens, Delabrouille, Jacques, Flauger, Raphael, Hanany, Shaul, Jones, William C., Kogut, Alan J., McMahon, Jeffrey J., Meyers, Joel, Sehgal, Neelima, Simon, Sara M., Umilta, Caterina, Abazajian, Kevork N., Ahmed, Zeeshan, Akrami, Yashar, Anderson, Adam J., Ansarinejad, Behzad, Austermann, Jason, Baccigalupi, Carlo, Barkats, Denis, Barron, Darcy, Barry, Peter S., Battaglia, Nicholas, Baxter, Eric, Beck, Dominic, Bender, Amy N., Bennett, Charles, Beringue, Benjamin, Bischoff, Colin, Bleem, Lindsey, Bock, James, Bolliet, Boris, Bond, J Richard, Borrill, Julian, Brinckmann, Thejs, Brown, Michael L., Calabrese, Erminia, Carlstrom, John, Challinor, Anthony, Chang, Chihway, Chinone, Yuji, Clark, Susan E., Coulton, William, Cukierman, Ari, Cyr-Racine, Francis-Yan, Duff, Shannon M., Dvorkin, Cora, van Engelen, Alexander, Errard, Josquin, Eskilt, Johannes R., Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey, Freese, Katherine, Galitzki, Nicholas, Gawiser, Eric, Grin, Daniel, Grohs, Evan, Gruppuso, Alessandro, Gudmundsson, Jon E., Halverson, Nils W., Hamilton, Jean-Christophe, Harrington, Kathleen, Henrot-Versillé, Sophie, Hensley, Brandon, Hill, J. Colin, Hincks, Adam D., Hlozek, Renee, Holzapfel, William, Hotinli, Selim C., Hui, Howard, Ibitoye, Ayodeji, Johnson, Matthew, Johnson, Bradley R., Kang, Jae Hwan, Karkare, Kirit S., Knox, Lloyd, Kovac, John, Lau, Kenny, Legrand, Louis, Loverde, Marilena, Lubin, Philip, Ma, Yin-Zhe, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagy, Johanna, Niemack, Michael, Novosad, Valentine, Omori, Yuuki, Orlando, Giorgio, Pan, Zhaodi, Perotto, Laurence, Petroff, Matthew A., Pogosian, Levon, Pryke, Clem, Rahlin, Alexandra, Raveri, Marco, Reichardt, Christian L., Remazeilles, Mathieu, Rephaeli, Yoel, Ruhl, John, Schaan, Emmanuel, Shandera, Sarah, Shimon, Meir, Soliman, Ahmed, Stark, Antony A., Starkman, Glenn D., Stompor, Radek, Thakur, Ritoban Basu, Trendafilova, Cynthia, Tristram, Matthieu, Trivedi, Pranjal, Tucker, Gregory, Di Valentino, Eleonora, Vieira, Joaquin, Vieregg, Abigail, Wang, Gensheng, Watson, Scott, Wenzl, Lukas, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Zegeye, David, and Zhang, Cheng
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: This is a solicited whitepaper for the Snowmass 2021 community planning exercise. The paper focuses on measurements and science with the Cosmic Microwave Background (CMB). The CMB is foundational to our understanding of modern physics and continues to be a powerful tool driving our understanding of cosmology and particle physics. In this paper, we outline the broad and unique impact of CMB science for the High Energy Cosmic Frontier in the upcoming decade. We also describe the progression of ground-based CMB experiments, which shows that the community is prepared to develop the key capabilities and facilities needed to achieve these transformative CMB measurements., Comment: contribution to Snowmass 2021
Published: 2022

21. Inflation: Theory and Observations

Author: Achúcarro, Ana, Biagetti, Matteo, Braglia, Matteo, Cabass, Giovanni, Caldwell, Robert, Castorina, Emanuele, Chen, Xingang, Coulton, William, Flauger, Raphael, Fumagalli, Jacopo, Ivanov, Mikhail M., Lee, Hayden, Maleknejad, Azadeh, Meerburg, P. Daniel, Dizgah, Azadeh Moradinezhad, Palma, Gonzalo A., Pimentel, Guilherme L., Renaux-Petel, Sébastien, Wallisch, Benjamin, Wandelt, Benjamin D., Witkowski, Lukas T., and Wu, W. L. Kimmy
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract: Cosmic inflation provides a window to the highest energy densities accessible in nature, far beyond those achievable in any realistic terrestrial experiment. Theoretical insights into the inflationary era and its observational probes may therefore shed unique light on the physical laws underlying our universe. This white paper describes our current theoretical understanding of the inflationary era, with a focus on the statistical properties of primordial fluctuations. In particular, we survey observational targets for three important signatures of inflation: primordial gravitational waves, primordial non-Gaussianity and primordial features. With the requisite advancements in analysis techniques, the tremendous increase in the raw sensitivities of upcoming and planned surveys will translate to leaps in our understanding of the inflationary paradigm and could open new frontiers for cosmology and particle physics. The combination of future theoretical and observational developments therefore offer the potential for a dramatic discovery about the nature of cosmic acceleration in the very early universe and physics on the smallest scales., Comment: Contribution to Snowmass 2021; 103 pages, 8 figures, 378 endorsers; v2: minor changes
Published: 2022

22. Snowmass 2021 CMB-S4 White Paper

Author: Abazajian, Kevork, Abdulghafour, Arwa, Addison, Graeme E., Adshead, Peter, Ahmed, Zeeshan, Ajello, Marco, Akerib, Daniel, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Amin, Mustafa A., Amiri, Mandana, Anderson, Adam, Ansarinejad, Behzad, Archipley, Melanie, Arnold, Kam S., Ashby, Matt, Aung, Han, Baccigalupi, Carlo, Baker, Carina, Bakshi, Abhishek, Bard, Debbie, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Barton, Paul, Thakur, Ritoban Basu, Battaglia, Nicholas, Beall, Jim, Bean, Rachel, Beck, Dominic, Belkner, Sebastian, Benabed, Karim, Bender, Amy N., Benson, Bradford A., Besuner, Bobby, Bethermin, Matthieu, Bhimani, Sanah, Bianchini, Federico, Biquard, Simon, Birdwell, Ian, Bischoff, Colin A., Bleem, Lindsey, Bocaz, Paulina, Bock, James J., Bocquet, Sebastian, Boddy, Kimberly K., Bond, J. Richard, Borrill, Julian, Bouchet, Francois R., Brinckmann, Thejs, Brown, Michael L., Bryan, Sean, Buza, Victor, Byrum, Karen, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chan, Victor, Chang, Clarence L., Chapman, Scott, Charles, Eric, Chauvin, Eric, Cheng, Cheng, Chesmore, Grace, Cheung, Kolen, Chinone, Yuji, Chluba, Jens, Cho, Hsiao-Mei Sherry, Choi, Steve, Clancy, Justin, Clark, Susan, Cooray, Asantha, Coppi, Gabriele, Corlett, John, Coulton, Will, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, Dai, Wei-Ming, Daley, Cail, Dart, Eli, Daues, Gregorg, de Haan, Tijmen, Deaconu, Cosmin, Delabrouille, Jacques, Derylo, Greg, Devlin, Mark, Di Valentino, Eleonora, Dierickx, Marion, Dober, Brad, Doriese, Randy, Duff, Shannon, Dutcher, Daniel, Dvorkin, Cora, Dünner, Rolando, Eftekhari, Tarraneh, Eimer, Joseph, Bouhargani, Hamza El, Elleflot, Tucker, Emerson, Nick, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Fanfani, Valentina, Fasano, Alessandro, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frisch, Josef, Frolov, Andrei, Galitzki, Nicholas, Gallardo, Patricio A., Galli, Silvia, Ganga, Ken, Gerbino, Martina, Giannakopoulos, Christos, Gilchriese, Murdock, Gluscevic, Vera, Goeckner-Wald, Neil, Goldfinger, David, Green, Daniel, Grimes, Paul, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Guarino, Vic, Gudmundsson, Jon E., Gullett, Ian, Guns, Sam, Habib, Salman, Haller, Gunther, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Hand, Emma, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Hensley, Brandon, Herbst, Ryan, Hervias-Caimapo, Carlos, Hill, J. Colin, Hills, Richard, Hivon, Eric, Hlozek, Renée, Ho, Anna, Holder, Gil, Hollister, Matt, Holzapfel, William, Hood, John, Hotinli, Selim, Hryciuk, Alec, Hubmayr, Johannes, Huffenberger, Kevin M., Hui, Howard, nez, Roberto Ibá, Ibitoye, Ayodeji, Ikape, Margaret, Irwin, Kent, Jacobus, Cooper, Jeong, Oliver, Johnson, Bradley R., Johnstone, Doug, Jones, William C., Joseph, John, Jost, Baptiste, Kang, Jae Hwan, Kaplan, Ari, Karkare, Kirit S., Katayama, Nobuhiko, Keskitalo, Reijo, King, Cesiley, Kisner, Theodore, Klein, Matthias, Knox, Lloyd, Koopman, Brian J., Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Krolewski, Alex, Kubik, Donna, Kuhlmann, Steve, Kuo, Chao-Lin, Kusaka, Akito, Lähteenmäki, Anne, Lau, Kenny, Lawrence, Charles R., Lee, Adrian T., Legrand, Louis, Leitner, Matthaeus, Leloup, Clément, Lewis, Antony, Li, Dale, Linder, Eric, Liodakis, Ioannis, Liu, Jia, Long, Kevin, Louis, Thibaut, Loverde, Marilena, Lowry, Lindsay, Lu, Chunyu, Lubin, Phil, Ma, Yin-Zhe, Maccarone, Thomas, Madhavacheril, Mathew S., Maldonado, Felipe, Mantz, Adam, Marques, Gabriela, Matsuda, Frederick, Mauskopf, Philip, May, Jared, McCarrick, Heather, McCracken, Ken, McMahon, Jeffrey, Meerburg, P. Daniel, Melin, Jean-Baptiste, Menanteau, Felipe, Meyers, Joel, Millea, Marius, Miranda, Vivian, Mitchell, Don, Mohr, Joseph, Moncelsi, Lorenzo, Monzani, Maria Elena, Moshed, Magdy, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagarajappa, Chandan, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Nerval, Simran, Newburgh, Laura, Nguyen, Hogan, Nichols, Erik, Nicola, Andrina, Niemack, Michael D., Nord, Brian, Norton, Tim, Novosad, Valentine, O'Brient, Roger, Omori, Yuuki, Orlando, Giorgio, Osherson, Benjamin, Osten, Rachel, Padin, Stephen, Paine, Scott, Partridge, Bruce, Patil, Sanjaykumar, Petravick, Don, Petroff, Matthew, Pierpaoli, Elena, Pilleux, Mauricio, Pogosian, Levon, Prabhu, Karthik, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Raghunathan, Srinivasan, Rahlin, Alexandra, Raveri, Marco, Reese, Ben, Reichardt, Christian L., Remazeilles, Mathieu, Rizzieri, Arianna, Rocha, Graca, Roe, Natalie A., Rotermund, Kaja, Roy, Anirban, Ruhl, John E., Saba, Joe, Sailer, Noah, Salatino, Maria, Saliwanchik, Benjamin, Sapozhnikov, Leonid, Rao, Mayuri Sathyanarayana, Saunders, Lauren, Schaan, Emmanuel, Schillaci, Alessandro, Schmitt, Benjamin, Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sherwin, Blake D., Shirokoff, Erik, Shiu, Corwin, Simon, Sara M., Singari, Baibhav, Slosar, Anze, Spergel, David, Germaine, Tyler St., Staggs, Suzanne T., Stark, Antony A., Starkman, Glenn D., Steinbach, Bryan, Stompor, Radek, Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Tandoi, Chris, Teply, Grant P., Thayer, Gregg, Thompson, Keith, Thorne, Ben, Timbie, Peter, Tomasi, Maurizio, Trendafilova, Cynthia, Tristram, Matthieu, Tucker, Carole, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, van Marrewijk, Joshiwa, Vavagiakis, Eve M., Vergès, Clara, Vieira, Joaquin D., Vieregg, Abigail G., Wagoner, Kasey, Wallisch, Benjamin, Wang, Gensheng, Wang, Guo-Jian, Watson, Scott, Watts, Duncan, Weaver, Chris, Wenzl, Lukas, Westbrook, Ben, White, Martin, Whitehorn, Nathan, Wiedlea, Andrew, Williams, Paul, Wilson, Robert, Winch, Harrison, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yefremenko, Volodymyr G., Yu, Cyndia, Zegeye, David, Zivick, Jeff, and Zonca, Andrea
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: This Snowmass 2021 White Paper describes the Cosmic Microwave Background Stage 4 project CMB-S4, which is designed to cross critical thresholds in our understanding of the origin and evolution of the Universe, from the highest energies at the dawn of time through the growth of structure to the present day. We provide an overview of the science case, the technical design, and project plan., Comment: Contribution to Snowmass 2021. arXiv admin note: substantial text overlap with arXiv:1908.01062, arXiv:1907.04473
Published: 2022

23. Snowmass2021 CMB-HD White Paper

Author: Collaboration, The CMB-HD, Aiola, Simone, Akrami, Yashar, Basu, Kaustuv, Boylan-Kolchin, Michael, Brinckmann, Thejs, Bryan, Sean, Casey, Caitlin M., Chluba, Jens, Clesse, Sebastien, Cyr-Racine, Francis-Yan, Di Mascolo, Luca, Dicker, Simon, Essinger-Hileman, Thomas, Farren, Gerrit S., Fedderke, Michael A., Ferraro, Simone, Fuller, George M., Galitzki, Nicholas, Gluscevic, Vera, Grin, Daniel, Han, Dongwon, Hasselfield, Matthew, Hlozek, Renee, Holder, Gil, Hotinli, Selim C., Jain, Bhuvnesh, Johnson, Bradley, Johnson, Matthew, Klaassen, Pamela, MacInnis, Amanda, Madhavacheril, Mathew, Mandal, Sayan, Mauskopf, Philip, Meerburg, Daan, Meyers, Joel, Miranda, Vivian, Mroczkowski, Tony, Mukherjee, Suvodip, Munchmeyer, Moritz, Munoz, Julian, Naess, Sigurd, Nagai, Daisuke, Namikawa, Toshiya, Newburgh, Laura, Nguyen, Ho Nam, Niemack, Michael, Oppenheimer, Benjamin D., Pierpaoli, Elena, Raghunathan, Srinivasan, Schaan, Emmanuel, Sehgal, Neelima, Sherwin, Blake, Simon, Sara M., Slosar, Anze, Smith, Kendrick, Spergel, David, Switzer, Eric R., Trivedi, Pranjal, Tsai, Yu-Dai, van Engelen, Alexander, Wandelt, Benjamin D., Wollack, Edward J., and Wu, Kimmy
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: CMB-HD is a proposed millimeter-wave survey over half the sky that would be ultra-deep (0.5 uK-arcmin) and have unprecedented resolution (15 arcseconds at 150 GHz). Such a survey would answer many outstanding questions about the fundamental physics of the Universe. Major advances would be 1.) the use of gravitational lensing of the primordial microwave background to map the distribution of matter on small scales (k~10 h Mpc^(-1)), which probes dark matter particle properties. It will also allow 2.) measurements of the thermal and kinetic Sunyaev-Zel'dovich effects on small scales to map the gas density and velocity, another probe of cosmic structure. In addition, CMB-HD would allow us to cross critical thresholds: 3.) ruling out or detecting any new, light (< 0.1 eV) particles that were in thermal equilibrium with known particles in the early Universe, 4.) testing a wide class of multi-field models that could explain an epoch of inflation in the early Universe, and 5.) ruling out or detecting inflationary magnetic fields. CMB-HD would also provide world-leading constraints on 6.) axion-like particles, 7.) cosmic birefringence, 8.) the sum of the neutrino masses, and 9.) the dark energy equation of state. The CMB-HD survey would be delivered in 7.5 years of observing 20,000 square degrees of sky, using two new 30-meter-class off-axis crossed Dragone telescopes to be located at Cerro Toco in the Atacama Desert. Each telescope would field 800,000 detectors (200,000 pixels), for a total of 1.6 million detectors., Comment: Contribution to Snowmass 2021. Note some text overlap with CMB-HD Astro2020 APC and RFI (arXiv:1906.10134, arXiv:2002.12714). Science case further broadened and updated
Published: 2022

24. Bias on Tensor-to-Scalar Ratio Inference With Estimated Covariance Matrices

Author: Beck, Dominic, Cukierman, Ari, and Wu, W. L. Kimmy
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We investigate simulation-based bandpower covariance matrices commonly used in cosmological parameter inferences such as the estimation of the tensor-to-scalar ratio $r$. We find that upper limits on $r$ can be biased low by tens of percent. The underestimation of the upper limit is most severe when the number of simulation realizations is similar to the number of observables. Convergence of the covariance-matrix estimation can require a number of simulations an order of magnitude larger than the number of observables, which could mean $\mathcal{O}(10\ 000)$ simulations. This is found to be caused by an additional scatter in the posterior probability of $r$ due to Monte Carlo noise in the estimated bandpower covariance matrix, in particular, by spurious non-zero off-diagonal elements. We show that matrix conditioning can be a viable mitigation strategy in the case that legitimate covariance assumptions can be made., Comment: 9 pages, 10 figures, accepted for publication in MNRAS
Published: 2022
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25. Mitochondrial dysfunction and neurodegeneration in multiple sclerosis

Author: Kimmy eSu, Dennis eBourdette, and Michael eForte
Subjects: Mitochondria, Multiple Sclerosis, neurodegeneration, neuronal viability, p66ShcA, Physiology, QP1-981
Abstract: Multiple sclerosis (MS) has traditionally been considered an autoimmune inflammatory disorder leading to demyelination and clinical debilitation as evidenced by our current standard anti-inflammatory and immunosuppressive treatment regimens. While these approaches do control the frequency of clinical relapses, they do not prevent the progressive functional decline that plagues many people with MS. Many avenues of research indicate that a neurodegenerative process may also play a significant role in MS from the early stages of disease, and one of the current hypotheses identifies mitochondrial dysfunction as a key contributing mechanism. We have hypothesized that pathological permeability transition pore opening mediated by reactive oxygen species and calcium dysregulation is central to mitochondrial dysfunction and neurodegeneration in MS. This focused review highlights recent evidence supporting this hypothesis, with particular emphasis on our in vitro and in vivo work with the mitochondria-targeted redox enzyme p66ShcA.
Published: 2013
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26. Integrating Insect Life History and Food Plant Phenology: Flexible Maternal Choice Is Adaptive

Author: Minghui Fei, Jeffrey A. Harvey, Berhane T. Weldegergis, Tzeyi Huang, Kimmy Reijngoudt, Louise M. Vet, and Rieta Gols
Subjects: endoparasitoid, foraging, glucosinolate, herbivore, herbivore induced plant volatile (HIPV), multivoltine, oviposition, rearing history, plant volatiles, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract: Experience of insect herbivores and their natural enemies in the natal habitat is considered to affect their likelihood of accepting a similar habitat or plant/host during dispersal. Growing phenology of food plants and the number of generations in the insects further determines lability of insect behavioural responses at eclosion. We studied the effect of rearing history on oviposition preference in a multivoltine herbivore (Pieris brassicae), and foraging behaviour in the endoparasitoid wasp (Cotesia glomerata) a specialist enemy of P. brassicae. Different generations of the insects are obligatorily associated with different plants in the Brassicaceae, e.g., Brassica rapa, Brassica nigra and Sinapis arvensis, exhibiting different seasonal phenologies in The Netherlands. Food plant preference of adults was examined when the insects had been reared on each of the three plant species for one generation. Rearing history only marginally affected oviposition preference of P. brassicae butterflies, but they never preferred the plant on which they had been reared. C. glomerata had a clear preference for host-infested B. rapa plants, irrespective of rearing history. Higher levels of the glucosinolate breakdown product 3-butenyl isothiocyanate in the headspace of B. rapa plants could explain enhanced attractiveness. Our results reveal the potential importance of flexible plant choice for female multivoltine insects in nature.
Published: 2016
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27. Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges

Author: Michael eForte, Dennis eBourdette, and Kimmy eSu
Subjects: Mitochondria, Oxidative Stress, neuronal viability, p66ShcA, Physiology, QP1-981
Abstract: Mitochondria are essential to neuronal viability and function due to their roles in ATP production, intracellular calcium regulation, and activation of apoptotic pathways. Accordingly, mitochondrial dysfunction has been indicated in a wide variety of neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, stroke and multiple sclerosis (MS). Recent evidence points to the permeability transition pore (PTP) as a key player in mitochondrial dysfunction in these diseases, in which pathologic opening leads to mitochondrial swelling, rupture, release of cytochrome c, and neuronal death. Reactive oxygen species (ROS), which are inducers of PTP opening, have been prominently implicated in the progression of many of these neurodegenerative diseases. In this context, inactivation of a mitochondria-targeted redox enzyme p66ShcA (p66) has been recently shown to prevent the neuronal cell death leading to axonal severing in the murine model of MS, experimental autoimmune encephalomyelitis (EAE). To further characterize the response of neurons lacking p66, we assessed their reaction to treatment with oxidative stressors implicated in neurodegenerative pathways. Specifically, p66-knockout (p66-KO) and wild-type (WT) neurons were treated with hydrogen peroxide (H2O2) and nitric oxide (NO), and assessed for cell viability and changes in mitochondrial properties, including morphology and ROS production. The results showed that p66-KO neurons had greater survival following treatment with oxidative stressors and generated less ROS when compared to WT neurons. Correspondingly, mitochondria in p66-KO neurons showed diminished morphological changes in response to these challenges. Overall, these findings highlight the importance of developing mitochondria-targeted therapeutics for neurodegenerative disorders, and emphasize p66, mitochondrial ROS, and the PTP as key targets for maintaining mitochondrial and neuronal integrity.
Published: 2012
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28. miR-132 mediates the integration of newborn neurons into the adult dentate gyrus.

Author: Bryan W Luikart, AeSoon L Bensen, Eric K Washburn, Julia V Perederiy, Kimmy G Su, Yun Li, Steven G Kernie, Luis F Parada, and Gary L Westbrook
Subjects: Medicine, Science
Abstract: Neuronal activity enhances the elaboration of newborn neurons as they integrate into the synaptic circuitry of the adult brain. The role microRNAs play in the transduction of neuronal activity into growth and synapse formation is largely unknown. MicroRNAs can influence the expression of hundreds of genes and thus could regulate gene assemblies during processes like activity-dependent integration. Here, we developed viral-based methods for the in vivo detection and manipulation of the activity-dependent microRNA, miR-132, in the mouse hippocampus. We find, using lentiviral and retroviral reporters of miR-132 activity, that miR-132 is expressed at the right place and right time to influence the integration of newborn neurons. Retroviral knockdown of miR-132 using a specific 'sponge' containing multiple target sequences impaired the integration of newborn neurons into the excitatory synaptic circuitry of the adult brain. To assess potential miR-132 targets, we used a whole-genome microarray in PC12 cells, which have been used as a model of neuronal differentiation. miR-132 knockdown in PC12 cells resulted in the increased expression of hundreds of genes. Functional grouping indicated that genes involved in inflammatory/immune signaling were the most enriched class of genes induced by miR-132 knockdown. The correlation of miR-132 knockdown to increased proinflammatory molecular expression may indicate a mechanistic link whereby miR-132 functions as an endogenous mediator of activity-dependent integration in vivo.
Published: 2011
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29. There is no interest in precious stones in a vegetable market: the life and sermons of Rabbi Jacob Gordon of Toronto

Author: Kimmy Caplan
Subjects: Language and Literature, Judaism, BM1-990, Sociology (General), HM401-1281
Abstract: A preliminary examination of Rabbi Jacob Gordon’s sermons within their biographical, communal, religious, historical, social, and cultural contexts, offers insight into the challenges Jewish immigrants faced in early twentieth century Toronto—as this Orthodox immigrant rabbi perceived them. These sermons provide details and perspectives, and they particularly illuminate doings within Toronto’s Orthodox-immigrant Jewish community. Gordon’s East-European background did not hold him back from remolding his style, as well as the content of his sermons, fully aware as he was of the need to modify his sermonic approach to respond to the novelties of Toronto’s immigrant world. Gordon’s sermons may also be compared to those of other North American contemporaries, again signaling the unique aspects of the Canadian Jewish religious experience at a critical moment.
Published: 2006
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30. DeepSZ: Identification of Sunyaev-Zel'dovich Galaxy Clusters using Deep Learning

Author: Lin, Zhen, Huang, Nicholas, Avestruz, Camille, Wu, W. L. Kimmy, Trivedi, Shubhendu, Caldeira, João, and Nord, Brian
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract: Galaxy clusters identified from the Sunyaev Zel'dovich (SZ) effect are a key ingredient in multi-wavelength cluster-based cosmology. We present a comparison between two methods of cluster identification: the standard Matched Filter (MF) method in SZ cluster finding and a method using Convolutional Neural Networks (CNN). We further implement and show results for a `combined' identifier. We apply the methods to simulated millimeter maps for several observing frequencies for an SPT-3G-like survey. There are some key differences between the methods. The MF method requires image pre-processing to remove point sources and a model for the noise, while the CNN method requires very little pre-processing of images. Additionally, the CNN requires tuning of hyperparameters in the model and takes as input, cutout images of the sky. Specifically, we use the CNN to classify whether or not an 8 arcmin $\times$ 8 arcmin cutout of the sky contains a cluster. We compare differences in purity and completeness. The MF signal-to-noise ratio depends on both mass and redshift. Our CNN, trained for a given mass threshold, captures a different set of clusters than the MF, some of which have SNR below the MF detection threshold. However, the CNN tends to mis-classify cutouts whose clusters are located near the edge of the cutout, which can be mitigated with staggered cutouts. We leverage the complementarity of the two methods, combining the scores from each method for identification. The purity and completeness of the MF alone are both 0.61, assuming a standard detection threshold. The purity and completeness of the CNN alone are 0.59 and 0.61. The combined classification method yields 0.60 and 0.77, a significant increase for completeness with a modest decrease in purity. We advocate for combined methods that increase the confidence of many lower signal-to-noise clusters.
Published: 2021
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31. Breaking the degeneracy between polarization efficiency and cosmological parameters in CMB experiments

Author: Galli, Silvia, Wu, W. L. Kimmy, Benabed, Karim, Bouchet, François, Crawford, Thomas M., and Hivon, Eric
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Accurate cosmological parameter estimates using polarization data of the cosmic microwave background (CMB) put stringent requirements on map calibration, as highlighted in the recent results from the Planck satellite. In this paper, we point out that a model-dependent determination of polarization calibration can be achieved by the joint fit of the TE and EE CMB power spectra. This provides a valuable cross-check to band-averaged polarization efficiency measurements determined using other approaches. We demonstrate that, in $\Lambda$CDM, the combination of the TE and EE constrain polarization calibration with sub-percent uncertainty with Planck data and 2% uncertainty with SPTpol data. We arrive at similar conclusions when extending $\Lambda$CDM to include the amplitude of lensing $A_{\rm L}$, the number of relativistic species $N_{\rm eff}$, or the sum of the neutrino masses $\sum m_{\nu}$. The uncertainties on cosmological parameters are minimally impacted when marginalizing over polarization calibration, except, as can be expected, for the uncertainty on the amplitude of the primordial scalar power spectrum $\ln(10^{10} A_{\rm s})$, which increases by $20-50$%. However, this information can be fully recovered by adding TT data. For current and future ground-based experiments, SPT-3G and CMB-S4, we forecast the cosmological parameter uncertainties to be minimally degraded when marginalizing over polarization calibration parameters. In addition, CMB-S4 could constrain its polarization calibration at the level of $\sim$0.2% by combining TE and EE, and reach $\sim$0.06% by also including TT. We therefore conclude that relying on calibrating against Planck polarization maps, whose statistical uncertainty is limited to $\sim$0.5%, would be insufficient for upcoming experiments., Comment: 11 pages, 8 figures. Comments welcome
Published: 2021
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32. CMB-S4: Forecasting Constraints on Primordial Gravitational Waves

Author: Collaboration, CMB-S4, Abazajian, Kevork, Addison, Graeme E., Adshead, Peter, Ahmed, Zeeshan, Akerib, Daniel, Ali, Aamir, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Amin, Mustafa A., Anderson, Adam, Arnold, Kam S., Ashton, Peter, Baccigalupi, Carlo, Bard, Debbie, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Thakur, Ritoban Basu, Battaglia, Nicholas, Bean, Rachel, Bebek, Chris, Bender, Amy N., Benson, Bradford A., Bianchini, Federico, Bischoff, Colin A., Bleem, Lindsey, Bock, James J., Bocquet, Sebastian, Boddy, Kimberly K., Bond, J. Richard, Borrill, Julian, Bouchet, François R., Brinckmann, Thejs, Brown, Michael L., Bryan, Sean, Buza, Victor, Byrum, Karen, Caimapo, Carlos Hervias, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chang, Clarence L., Chinone, Yuji, Cho, Hsiao-Mei Sherry, Cooray, Asantha, Coulton, Will, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, de Haan, Tijmen, Delabrouille, Jacques, Devlin, Mark, Di Valentino, Eleonora, Dierickx, Marion, Dobbs, Matt, Duff, Shannon, Dunkley, Jo, Dvorkin, Cora, Eimer, Joseph, Elleflot, Tucker, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frolov, Andrei, Galitzki, Nicholas, Gallardo, Patricio A., Galli, Silvia, Ganga, Ken, Gerbino, Martina, Gluscevic, Vera, Goeckner-Wald, Neil, Green, Daniel, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Gudmundsson, Jon E., Gullett, Ian, Gupta, Nikhel, Habib, Salman, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Hensley, Brandon, Hill, Charles, Hill, J. Colin, Hlozek, Renée, Ho, Shuay-Pwu Patty, Hoang, Thuong, Holder, Gil, Holzapfel, William, Hood, John, Hubmayr, Johannes, Huffenberger, Kevin M., Hui, Howard, Irwin, Kent, Jeong, Oliver, Johnson, Bradley R., Jones, William C., Kang, Jae Hwan, Karkare, Kirit S., Katayama, Nobuhiko, Keskitalo, Reijo, Kisner, Theodore, Knox, Lloyd, Koopman, Brian J., Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuhlmann, Steve, Kuo, Chao-lin, Kusaka, Akito, Lähteenmäki, Anne, Lawrence, Charles R., Lee, Adrian T., Lewis, Antony, Li, Dale, Linder, Eric, Loverde, Marilena, Lowitz, Amy, Lubin, Phil, Madhavacheril, Mathew S., Mantz, Adam, Marques, Gabriela, Matsuda, Frederick, Mauskopf, Philip, McCarrick, Heather, McMahon, Jeffrey, Meerburg, P. Daniel, Melin, Jean-Baptiste, Menanteau, Felipe, Meyers, Joel, Millea, Marius, Mohr, Joseph, Moncelsi, Lorenzo, Monzani, Maria, Mroczkowski, Tony, Mukherjee, Suvodip, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Newburgh, Laura, Niemack, Michael D., Nishino, Haruki, Nord, Brian, Novosad, Valentine, O'Brient, Roger, Padin, Stephen, Palladino, Steven, Partridge, Bruce, Petravick, Don, Pierpaoli, Elena, Pogosian, Levon, Prabhu, Karthik, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Rahlin, Alexandra, Rao, Mayuri Sathyanarayana, Raveri, Marco, Reichardt, Christian L., Remazeilles, Mathieu, Rocha, Graca, Roe, Natalie A., Roy, Anirban, Ruhl, John E., Salatino, Maria, Saliwanchik, Benjamin, Schaan, Emmanuel, Schillaci, Alessandro, Schmitt, Benjamin, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sherwin, Blake D., Shirokoff, Erik, Simon, Sara M., Slosar, Anze, Spergel, David, Germaine, Tyler St., Staggs, Suzanne T., Stark, Antony, Starkman, Glenn D., Stompor, Radek, Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Teply, Grant P., Thompson, Keith, Thorne, Ben, Timbie, Peter, Tomasi, Maurizio, Tristram, Matthieu, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, Vavagiakis, Eve M., Vieira, Joaquin D., Vieregg, Abigail G., Wagoner, Kasey, Wallisch, Benjamin, Wang, Gensheng, Watson, Scott, Westbrook, Ben, Whitehorn, Nathan, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yang, H. Y. Eric, Yasini, Siavash, Yefremenko, Volodymyr G., Yoon, Ki Won, Young, Edward, Yu, Cyndia, and Zonca, Andrea
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: CMB-S4---the next-generation ground-based cosmic microwave background (CMB) experiment---is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the Universe, from the highest energies at the dawn of time through the growth of structure to the present day. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semi-analytic projection tool, targeted explicitly towards optimizing constraints on the tensor-to-scalar ratio, $r$, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2--3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments given a desired scientific goal. To form a closed-loop process, we couple this semi-analytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for $r > 0.003$ at greater than $5\sigma$, or, in the absence of a detection, of reaching an upper limit of $r < 0.001$ at $95\%$ CL., Comment: 24 pages, 8 figures, 9 tables, submitted to ApJ. arXiv admin note: text overlap with arXiv:1907.04473
Published: 2020
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33. Near-conformal dynamics in a chirally broken system

Author: Appelquist, Thomas, Brower, Richard C., Cushman, Kimmy K., Fleming, George T., Gasbarro, Andrew D., Hasenfratz, Anna, Jin, Xiao-Yong, Neil, Ethan T., Osborn, James C., Rebbi, Claudio, Rinaldi, Enrico, Schaich, David, Vranas, Pavlos, and Witzel, Oliver
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Lattice
Abstract: Composite Higgs models must exhibit very different dynamics from quantum chromodynamics (QCD) regardless whether they describe the Higgs boson as a dilatonlike state or a pseudo-Nambu-Goldstone boson. Large separation of scales and large anomalous dimensions are frequently desired by phenomenological models. Mass-split systems are well-suited for composite Higgs models because they are governed by a conformal fixed point in the ultraviolet but are chirally broken in the infrared. In this work we use lattice field theory calculations with domain wall fermions to investigate a system with four light and six heavy flavors. We demonstrate how a nearby conformal fixed point affects the properties of the four light flavors that exhibit chiral symmetry breaking in the infrared. Specifically we describe hyperscaling of dimensionful physical quantities and determine the corresponding anomalous mass dimension. We obtain $y_m=1+\gamma^*= 1.47(5)$ suggesting that $N_f=10$ lies inside the conformal window. Comparing the low energy spectrum to predictions of dilaton chiral perturbation theory, we observe excellent agreement which supports the expectation that the 4+6 mass-split system exhibits near-conformal dynamics with a relatively light $0^{++}$ isosinglet scalar., Comment: 7 pages, 5 figures, v2 version published in Phys. Rev. D
Published: 2020
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34. Hubble constant difference between CMB lensing and BAO measurements

Author: Wu, W. L. Kimmy, Motloch, Pavel, Hu, Wayne, and Raveri, Marco
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We apply a tension metric $Q_\textrm{UDM}$, the update difference in mean parameters, to understand the source of the difference in the measured Hubble constant $H_0$ inferred with cosmic microwave background lensing measurements from the Planck satellite ($H_0=67.9^{+1.1}_{-1.3}\, \mathrm{km/s/Mpc}$) and from the South Pole Telescope ($H_0=72.0^{+2.1}_{-2.5}\, \mathrm{km/s/Mpc}$) when both are combined with baryon acoustic oscillation (BAO) measurements with priors on the baryon density (BBN). $Q_\textrm{UDM}$ isolates the relevant parameter directions for tension or concordance where the two data sets are both informative, and aids in the identification of subsets of data that source the observed tension. With $Q_\textrm{UDM}$, we uncover that the difference in $H_0$ is driven by the tension between Planck lensing and BAO+BBN, at probability-to-exceed of 6.6%. Most of this mild tension comes from the galaxy BAO measurements parallel to the line of sight. The redshift dependence of the parallel BAOs pulls both the matter density $\Omega_m$ and $H_0$ high in $\Lambda$CDM, but these parameter anomalies are usually hidden when the BAO measurements are combined with other cosmological data sets with much stronger $\Omega_m$ constraints., Comment: 9 pages, 9 figures. Match published version
Published: 2020
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35. Automated label flows for excited states of correlation functions in lattice gauge theory

Author: Cushman, Kimmy K. and Fleming, George T.
Subjects: High Energy Physics - Lattice
Abstract: Extracting excited states from lattice gauge theory correlation functions can be achieved through chi-squared minimization fits or algebraic approaches such as the variational method and Prony's method. Performing any kind of error analysis, such as bootstrap resampling, often leads to overlapping confidence regions of model parameters, even when the spectrum is not particularly dense. In order to correctly estimate errors, one must beware of mislabeling the states. In this work, we provide an algorithm that we call automated label flows which consistently and systematically identifies a deterministic labeling of states. In the context of Prony's method, we analyze lattice correlation functions by using automated label flows, and compare the results to fits obtained from chi-square minimization fits to exponentials., Comment: 15 pages, 20 figures, submitted to Phys. Rev. D
Published: 2019
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36. CMB-S4 Decadal Survey APC White Paper

Author: Abazajian, Kevork, Addison, Graeme, Adshead, Peter, Ahmed, Zeeshan, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Amin, Mustafa A., Anderson, Adam, Arnold, Kam S., Baccigalupi, Carlo, Bailey, Kathy, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Thakur, Ritoban Basu, Battaglia, Nicholas, Baxter, Eric, Bean, Rachel, Bebek, Chris, Bender, Amy N., Benson, Bradford A., Berger, Edo, Bhimani, Sanah, Bischoff, Colin A., Bleem, Lindsey, Bock, James J., Bocquet, Sebastian, Boddy, Kimberly, Bonato, Matteo, Bond, J. Richard, Borrill, Julian, Bouchet, François R., Brown, Michael L., Bryan, Sean, Burkhart, Blakesley, Buza, Victor, Byrum, Karen, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chang, Clarence L., Chinone, Yuji, Cho, Hsiao-Mei Sherry, Cooray, Asantha, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, de Haan, Tijmen, de Zotti, Gianfranco, Delabrouille, Jacques, Demarteau, Marcel, Devlin, Mark, Di Valentino, Eleonora, Dobbs, Matt, Duff, Shannon, Duivenvoorden, Adriaan, Dvorkin, Cora, Edwards, William, Eimer, Joseph, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frolov, Andrei, Galitzki, Nicholas, Galli, Silvia, Ganga, Ken, Gerbino, Martina, Gilchriese, Murdock, Gluscevic, Vera, Green, Daniel, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Guarino, Victor, Gudmundsson, Jon E., Habib, Salman, Haller, Gunther, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Henning, Jason W., Hill, J. Colin, Hlozek, Renée, Holder, Gil, Holzapfel, William, Hubmayr, Johannes, Huffenberger, Kevin M., Huffer, Michael, Hui, Howard, Irwin, Kent, Johnson, Bradley R., Johnstone, Doug, Jones, William C., Karkare, Kirit, Katayama, Nobuhiko, Kerby, James, Kernovsky, Sarah, Keskitalo, Reijo, Kisner, Theodore, Knox, Lloyd, Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuhlmann, Steve, Kuo, Chao-lin, Kurita, Nadine, Kusaka, Akito, Lahteenmaki, Anne, Lawrence, Charles R., Lee, Adrian T., Lewis, Antony, Li, Dale, Linder, Eric, Loverde, Marilena, Lowitz, Amy, Madhavacheril, Mathew S., Mantz, Adam, Matsuda, Frederick, Mauskopf, Philip, McMahon, Jeff, Meerburg, P. Daniel, Melin, Jean-Baptiste, Meyers, Joel, Millea, Marius, Mohr, Joseph, Moncelsi, Lorenzo, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Negrello, Mattia, Newburgh, Laura, Niemack, Michael D., Nishino, Haruki, Nordby, Martin, Novosad, Valentine, O'Connor, Paul, Obied, Georges, Padin, Stephen, Pandey, Shivam, Partridge, Bruce, Pierpaoli, Elena, Pogosian, Levon, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Raghunathan, Srinivasan, Rahlin, Alexandra, Rajagopalan, Srini, Raveri, Marco, Reichanadter, Mark, Reichardt, Christian L., Remazeilles, Mathieu, Rocha, Graca, Roe, Natalie A., Roy, Anirban, Ruhl, John, Salatino, Maria, Saliwanchik, Benjamin, Schaan, Emmanuel, Schillaci, Alessandro, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sheehy, Christopher, Sherwin, Blake D., Shirokoff, Erik, Simon, Sara M., Slosar, Anze, Somerville, Rachel, Staggs, Suzanne T., Stark, Antony, Stompor, Radek, Story, Kyle T., Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Teply, Grant P., Thompson, Keith, Timbie, Peter, Tomasi, Maurizio, Treu, Jesse I., Tristram, Matthieu, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, Vieira, Joaquin D., Vieregg, Abigail G., Vogelsberger, Mark, Wang, Gensheng, Watson, Scott, White, Martin, Whitehorn, Nathan, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yasini, Siavash, Yeck, James, Yoon, Ki Won, Young, Edward, and Zonca, Andrea
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: We provide an overview of the science case, instrument configuration and project plan for the next-generation ground-based cosmic microwave background experiment CMB-S4, for consideration by the 2020 Decadal Survey., Comment: Project White Paper submitted to the 2020 Decadal Survey, 10 pages plus references. arXiv admin note: substantial text overlap with arXiv:1907.04473
Published: 2019

37. CMB-S4 Science Case, Reference Design, and Project Plan

Author: Abazajian, Kevork, Addison, Graeme, Adshead, Peter, Ahmed, Zeeshan, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Anderson, Adam, Arnold, Kam S., Baccigalupi, Carlo, Bailey, Kathy, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Thakur, Ritoban Basu, Battaglia, Nicholas, Baxter, Eric, Bean, Rachel, Bebek, Chris, Bender, Amy N., Benson, Bradford A., Berger, Edo, Bhimani, Sanah, Bischoff, Colin A., Bleem, Lindsey, Bocquet, Sebastian, Boddy, Kimberly, Bonato, Matteo, Bond, J. Richard, Borrill, Julian, Bouchet, François R., Brown, Michael L., Bryan, Sean, Burkhart, Blakesley, Buza, Victor, Byrum, Karen, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chang, Clarence L., Chinone, Yuji, Cho, Hsiao-Mei Sherry, Cooray, Asantha, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, de Haan, Tijmen, de Zotti, Gianfranco, Delabrouille, Jacques, Demarteau, Marcel, Devlin, Mark, Di Valentino, Eleonora, Dobbs, Matt, Duff, Shannon, Duivenvoorden, Adriaan, Dvorkin, Cora, Edwards, William, Eimer, Joseph, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frolov, Andrei, Galitzki, Nicholas, Galli, Silvia, Ganga, Ken, Gerbino, Martina, Gilchriese, Murdock, Gluscevic, Vera, Green, Daniel, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Guarino, Victor, Gudmundsson, Jon E., Habib, Salman, Haller, Gunther, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Henning, Jason W., Hill, J. Colin, Hlozek, Renée, Holder, Gil, Holzapfel, William, Hubmayr, Johannes, Huffenberger, Kevin M., Huffer, Michael, Hui, Howard, Irwin, Kent, Johnson, Bradley R., Johnstone, Doug, Jones, William C., Karkare, Kirit, Katayama, Nobuhiko, Kerby, James, Kernovsky, Sarah, Keskitalo, Reijo, Kisner, Theodore, Knox, Lloyd, Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuhlmann, Steve, Kuo, Chao-lin, Kurita, Nadine, Kusaka, Akito, Lahteenmaki, Anne, Lawrence, Charles R., Lee, Adrian T., Lewis, Antony, Li, Dale, Linder, Eric, Loverde, Marilena, Lowitz, Amy, Madhavacheril, Mathew S., Mantz, Adam, Matsuda, Frederick, Mauskopf, Philip, McMahon, Jeff, McQuinn, Matthew, Meerburg, P. Daniel, Melin, Jean-Baptiste, Meyers, Joel, Millea, Marius, Mohr, Joseph, Moncelsi, Lorenzo, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Negrello, Mattia, Newburgh, Laura, Niemack, Michael D., Nishino, Haruki, Nordby, Martin, Novosad, Valentine, O'Connor, Paul, Obied, Georges, Padin, Stephen, Pandey, Shivam, Partridge, Bruce, Pierpaoli, Elena, Pogosian, Levon, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Raghunathan, Srinivasan, Rahlin, Alexandra, Rajagopalan, Srini, Raveri, Marco, Reichanadter, Mark, Reichardt, Christian L., Remazeilles, Mathieu, Rocha, Graca, Roe, Natalie A., Roy, Anirban, Ruhl, John, Salatino, Maria, Saliwanchik, Benjamin, Schaan, Emmanuel, Schillaci, Alessandro, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sheehy, Christopher, Sherwin, Blake D., Shirokoff, Erik, Simon, Sara M., Slosar, Anze, Somerville, Rachel, Spergel, David, Staggs, Suzanne T., Stark, Antony, Stompor, Radek, Story, Kyle T., Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Teply, Grant P., Thompson, Keith, Timbie, Peter, Tomasi, Maurizio, Treu, Jesse I., Tristram, Matthieu, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, Vieira, Joaquin D., Vieregg, Abigail G., Vogelsberger, Mark, Wang, Gensheng, Watson, Scott, White, Martin, Whitehorn, Nathan, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yasini, Siavash, Yeck, James, Yoon, Ki Won, Young, Edward, and Zonca, Andrea
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Experiment
Abstract: We present the science case, reference design, and project plan for the Stage-4 ground-based cosmic microwave background experiment CMB-S4., Comment: 287 pages, 82 figures
Published: 2019

38. Prony methods for extracting excited states

Author: Cushman, Kimmy K. and Fleming, George T.
Subjects: High Energy Physics - Lattice
Abstract: We propose an algebraic method for extracting excited states from lattice gauge theory correlation functions. Instead of fitting to a sum of decaying exponentials, we adopt a variant of Prony's method to obtain $M$ energies (exponential decay rates) by finding the roots of an $M^{\rm th}$ order polynomial, and then solving for the amplitudes linearly. The resulting states tend to have overlapping error ellipses, making identification of states ambiguous. This is especially problematic at large Euclidean times where the signal to noise may be low, as well as when many states are extracted. We propose a variation of K-means clustering to identify each extracted state., Comment: 7 pages, 9 figures, Lattice 2018 proceedings
Published: 2019

39. Sounds Discordant: Classical Distance Ladder & $\Lambda$CDM -based Determinations of the Cosmological Sound Horizon

Author: Aylor, Kevin, Joy, Mackenzie, Knox, Lloyd, Millea, Marius, Raghunathan, Srinivasan, and Wu, W. L. Kimmy
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Type Ia Supernovae, calibrated by classical distance ladder methods, can be used, in conjunction with galaxy survey two-point correlation functions, to empirically determine the size of the sound horizon $r_{\rm s}$. Assumption of the $\Lambda$CDM model, together with data to constrain its parameters, can also be used to determine the size of the sound horizon. Using a variety of cosmic microwave background (CMB) datasets to constrain $\Lambda$CDM parameters, we find the model-based sound horizon to be larger than the empirically-determined one with a statistical significance of between 2 and 3$\sigma$, depending on the dataset. If reconciliation requires a change to the cosmological model, we argue that change is likely to be important in the two decades of scale factor evolution prior to recombination. Future CMB observations will therefore likely be able to test any such adjustments; e.g., a third generation CMB survey like SPT-3G can achieve a three-fold improvement in the constraints on $r_{\rm s}$ in the $\Lambda$CDM model extended to allow additional light degrees of freedom., Comment: 12 pages, 3 figures, published in ApJ
Published: 2018
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40. DeepCMB: Lensing Reconstruction of the Cosmic Microwave Background with Deep Neural Networks

Author: Caldeira, João, Wu, W. L. Kimmy, Nord, Brian, Avestruz, Camille, Trivedi, Shubhendu, and Story, Kyle T.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Computer Science - Computer Vision and Pattern Recognition, Statistics - Machine Learning
Abstract: Next-generation cosmic microwave background (CMB) experiments will have lower noise and therefore increased sensitivity, enabling improved constraints on fundamental physics parameters such as the sum of neutrino masses and the tensor-to-scalar ratio r. Achieving competitive constraints on these parameters requires high signal-to-noise extraction of the projected gravitational potential from the CMB maps. Standard methods for reconstructing the lensing potential employ the quadratic estimator (QE). However, the QE performs suboptimally at the low noise levels expected in upcoming experiments. Other methods, like maximum likelihood estimators (MLE), are under active development. In this work, we demonstrate reconstruction of the CMB lensing potential with deep convolutional neural networks (CNN) - ie, a ResUNet. The network is trained and tested on simulated data, and otherwise has no physical parametrization related to the physical processes of the CMB and gravitational lensing. We show that, over a wide range of angular scales, ResUNets recover the input gravitational potential with a higher signal-to-noise ratio than the QE method, reaching levels comparable to analytic approximations of MLE methods. We demonstrate that the network outputs quantifiably different lensing maps when given input CMB maps generated with different cosmologies. We also show we can use the reconstructed lensing map for cosmological parameter estimation. This application of CNN provides a few innovations at the intersection of cosmology and machine learning. First, while training and regressing on images, we predict a continuous-variable field rather than discrete classes. Second, we are able to establish uncertainty measures for the network output that are analogous to standard methods. We expect this approach to excel in capturing hard-to-model non-Gaussian astrophysical foreground and noise contributions., Comment: 19 pages; LaTeX; 12 figures; changes to match published version
Published: 2018
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41. Social vs. non-social measures of learning potential for predicting community functioning across phase of illness in schizophrenia

Author: Clayson, Peter E, Kern, Robert S, Nuechterlein, Keith H, Knowlton, Barbara J, Bearden, Carrie E, Cannon, Tyrone D, Fiske, Alan P, Ghermezi, Livon, Hayata, Jacqueline N, Hellemann, Gerhard S, Horan, William P, Kee, Kimmy, Lee, Junghee, Subotnik, Kenneth L, Sugar, Catherine A, Ventura, Joseph, Yee, Cindy M, and Green, Michael F
Subjects: Schizophrenia, Rehabilitation, Clinical Research, Mental Health, Basic Behavioral and Social Science, Brain Disorders, Behavioral and Social Science, Serious Mental Illness, Neurosciences, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Mental health, Adolescent, Adult, Chronic Disease, Cognitive Dysfunction, Disease Progression, Female, Humans, Learning, Male, Risk, Social Perception, Young Adult, Social cognition, Learning potential, Dynamic assessment, WCST, FEIT, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: Studies demonstrate that dynamic assessment (i.e., learning potential) improves the prediction of response to rehabilitation over static measures in individuals with schizophrenia. Learning potential is most commonly assessed using neuropsychological tests under a test-train-test paradigm to examine change in performance. Novel learning potential approaches using social cognitive tasks may have added value, particularly for the prediction of social functioning, but this area is unexplored. The present study is the first to investigate whether patients with schizophrenia demonstrate social cognitive learning potential across phase of illness. This study included 43 participants at clinical high risk (CHR), 63 first-episode, and 36 chronic schizophrenia patients. Assessment of learning potential involved test-train-test versions of the Wisconsin Card Sorting Test (non-social cognitive learning potential) and the Facial Emotion Identification Test (social cognitive learning potential). Non-social and social cognition pre-training scores (static scores) uniquely predicted concurrent community functioning in patients with schizophrenia, but not in CHR participants. Learning potential showed no incremental explanation of variance beyond static scores. First-episode patients showed larger non-social cognitive learning potential than CHR participants and were similar to chronic patients; chronic patients and CHR participants were similar. Group differences across phase of illness were not observed for social cognitive learning potential. Subsequent research could explore whether non-social and social cognitive learning potential relate differentially to non-social versus social types of training and rehabilitation.
Published: 2019

42. Transcriptional profiling reveals signatures of latent developmental potential in Arabidopsis stomatal lineage ground cells

Author: Ho, Chin-Min Kimmy, Bringmann, Martin, Oshima, Yoshimi, Mitsuda, Nobutaka, and Bergmann, Dominique C.
Published: 2021

43. Episodic Memory for Dynamic Social Interaction Across Phase of Illness in Schizophrenia.

Author: Lee, Junghee, Nuechterlein, Keith H, Knowlton, Barbara J, Bearden, Carrie E, Cannon, Tyrone D, Fiske, Alan P, Ghermezi, Livon, Hayata, Jacqueline N, Hellemann, Gerhard S, Horan, William P, Kee, Kimmy, Kern, Robert S, Subotnik, Kenneth L, Sugar, Catherine A, Ventura, Joseph, Yee, Cindy M, and Green, Michael F
Subjects: Humans, Memory Disorders, Disease Progression, Risk, Interpersonal Relations, Mental Recall, Schizophrenia, Adolescent, Adult, Middle Aged, Female, Male, Young Adult, Memory, Episodic, Recognition, Psychology, Mental Health, Clinical Research, Brain Disorders, Neurosciences, Serious Mental Illness, Aetiology, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Mental health, social episodic memory, recollection, familiarity, social context, schizophrenia, phase of illness, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: Although a number of studies examined recollection and familiarity memory in schizophrenia, most of studies have focused on nonsocial episodic memory. Little is known about how schizophrenia patients remember social information in everyday life and whether social episodic memory changes over the course of illness. This study aims to examine episodic memory for dynamic social interaction with multimodal social stimuli in schizophrenia across phase of illness. Within each phase of illness, probands and demographically matched controls participated: 51 probands at clinical high risk (CHR) for psychosis and 36 controls, 80 first-episode schizophrenia patients and 49 controls, and 50 chronic schizophrenia patients and 39 controls. The participants completed the Social Remember-Know Paradigm that assessed overall social episodic memory, social recollection and familiarity memory, and social context memory, in addition to social cognitive measures and measures on community functioning. Probands showed impairment for recollection but not in familiarity memory and this pattern was similar across phase of illness. In contrast, impaired social context memory was observed in the first-episode and chronic schizophrenia samples, but not in CHR samples. Social context memory was associated with community functioning only in the chronic sample. These findings suggest that an impaired recollection could be a vulnerability marker for schizophrenia whereas impaired social context memory could be a disease-related marker. Further, a pattern of impaired recollection with intact familiarity memory for social stimuli suggests that schizophrenia patients may have a different pattern of impaired episodic memory for social vs nonsocial stimuli.
Published: 2018

44. CMB-S4 Science Book, First Edition

Author: Abazajian, Kevork N., Adshead, Peter, Ahmed, Zeeshan, Allen, Steven W., Alonso, David, Arnold, Kam S., Baccigalupi, Carlo, Bartlett, James G., Battaglia, Nicholas, Benson, Bradford A., Bischoff, Colin A., Borrill, Julian, Buza, Victor, Calabrese, Erminia, Caldwell, Robert, Carlstrom, John E., Chang, Clarence L., Crawford, Thomas M., Cyr-Racine, Francis-Yan, De Bernardis, Francesco, de Haan, Tijmen, Alighieri, Sperello di Serego, Dunkley, Joanna, Dvorkin, Cora, Errard, Josquin, Fabbian, Giulio, Feeney, Stephen, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Fuller, George M., Gluscevic, Vera, Green, Daniel, Grin, Daniel, Grohs, Evan, Henning, Jason W., Hill, J. Colin, Hlozek, Renee, Holder, Gilbert, Holzapfel, William, Hu, Wayne, Huffenberger, Kevin M., Keskitalo, Reijo, Knox, Lloyd, Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuo, Chao-Lin, Kusaka, Akito, Jeune, Maude Le, Lee, Adrian T., Lilley, Marc, Loverde, Marilena, Madhavacheril, Mathew S., Mantz, Adam, Marsh, David J. E., McMahon, Jeffrey, Meerburg, Pieter Daniel, Meyers, Joel, Miller, Amber D., Munoz, Julian B., Nguyen, Ho Nam, Niemack, Michael D., Peloso, Marco, Peloton, Julien, Pogosian, Levon, Pryke, Clement, Raveri, Marco, Reichardt, Christian L., Rocha, Graca, Rotti, Aditya, Schaan, Emmanuel, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sherwin, Blake D., Smith, Tristan L., Sorbo, Lorenzo, Starkman, Glenn D., Story, Kyle T., van Engelen, Alexander, Vieira, Joaquin D., Watson, Scott, Whitehorn, Nathan, and Wu, W. L. Kimmy
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract: This book lays out the scientific goals to be addressed by the next-generation ground-based cosmic microwave background experiment, CMB-S4, envisioned to consist of dedicated telescopes at the South Pole, the high Chilean Atacama plateau and possibly a northern hemisphere site, all equipped with new superconducting cameras. CMB-S4 will dramatically advance cosmological studies by crossing critical thresholds in the search for the B-mode polarization signature of primordial gravitational waves, in the determination of the number and masses of the neutrinos, in the search for evidence of new light relics, in constraining the nature of dark energy, and in testing general relativity on large scales.
Published: 2016

45. Harnessing the tumor draining lymph node for effective anti-tumor immunity in breast cancer and melanoma

Author: van Pul, Kimmy Martine and van Pul, Kimmy Martine
Abstract: Part 1: Technical aspects of TDLN immune monitoring Viable cell scrapings of the surgically retrieved and bisected SLN offer a unique opportunity to study tumor induced and/or immune modulator effects. In chapter 2, as part of a special issue on new guidelines for DC research for the European Journal of Immunology (submitted), we describe our method of obtaining viable LN cell suspensions and their use for flowcytomety based characterization of TDLN DC subsets. Cryopreservation of SLN single-cell suspensions allows for simultaneous phenotypic multi-parameter analyses and minimizes operator dependent variability. This would be of particular importance for immune monitoring in future multi-center trials. In Chapter 3, we tested the feasibility of cryopreservation of viable SLN cell samples for flowcytometric analysis, by comparing quantitative DC and T Cell analyses of SLN cell samples after freeze-thawing with direct analysis of fresh SLN cell samples (n=9). Although these techniques should not be employed interchangeably in the same trial, cryopreservation and thawing is a valid alternative to direct analysis of fresh viable lymph node cells, without introducing cryo-dependent variance between SLN samples. Part 2: Breast cancer In order to unravel the immune landscape in BrC TDLN, in Chapter 4, we describe the results of a comprehensive flow cytometry–assisted study of viable cells from BrC SLN (n=58) in a comparative analysis with healthy (i.e. prophylactic mastectomy-derived) axillary lymph nodes (HLN, n=17) and show that BrC induced immune suppression coincides with selectively hampered activation of LNR DC subsets. The knowledge that CpG-B can preferentially activate these LNR DC subsets but also induce STAT-3 (a known poor prognostic indicator in BrC and the master switch of tumor induced immune suppression) prompted the ex-vivo functional validation of combined TLR9 targeting and JAK2/STAT3 inhibition as a potential treatment strategy in breast cancer patients
Published: 2024
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46. Visual topography and perceptual learning in the primate visual system

Author: Tang-Wright, Kimmy, Krug, Kristine, and Parker, Andrew
Subjects: 612.8, Psychology, Neurosciences, lateral geniculate nucleus, diffusion-weighted imaging, anatomy, task-irrelevant perceptual learning, macaque, DTI, probabilistic tractography, neuroimaging, diffusion, perceptual learning, vision
Abstract: The primate visual system is organised and wired in a topological manner. From the eye well into extrastriate visual cortex, a preserved spatial representation of the vi- sual world is maintained across many levels of processing. Diffusion-weighted imaging (DWI), together with probabilistic tractography, is a non-invasive technique for map- ping connectivity within the brain. In this thesis I probed the sensitivity and accuracy of DWI and probabilistic tractography by quantifying its capacity to detect topolog- ical connectivity in the post mortem macaque brain, between the lateral geniculate nucleus (LGN) and primary visual cortex (V1). The results were validated against electrophysiological and histological data from previous studies. Using the methodol- ogy developed in this thesis, it was possible to segment the LGN reliably into distinct subregions based on its structural connectivity to different parts of the visual field represented in V1. Quantitative differences in connectivity from magno- and parvo- cellular subcomponents of the LGN to different parts of V1 could be replicated with this method in post mortem brains. The topological corticocortical connectivity be- tween extrastriate visual area V5/MT and V1 could also be mapped in the post mortem macaque. In vivo DWI scans previously obtained from the same brains have lower resolution and signal-to-noise because of the shorter scan times. Nevertheless, in many cases, these yielded topological maps similar to the post mortem maps. These results indicate that the preserved topology of connection between LGN to V1, and V5/MT to V1, can be revealed using non-invasive measures of diffusion-weighted imaging and tractography in vivo. In a preliminary investigation using Human Connectome data obtained in vivo, I was not able to segment the retinotopic map in LGN based on con- nections to V1. This may be because information about the topological connectivity is not carried in the much lower resolution human diffusion data, or because of other methodological limitations. I also investigated the mechanisms of perceptual learning by developing a novel task-irrelevant perceptual learning paradigm designed to adapt neuronal elements early on in visual processing in a certain region of the visual field. There is evidence, although not clear-cut, to suggest that the paradigm elicits task- irrelevant perceptual learning, but that these effects only emerge when practice-related effects are accounted for. When orientation and location specific effects on perceptual performance are examined, the largest improvement occurs at the trained location, however, there is also significant improvement at one other 'untrained' location, and there is also a significant improvement in performance for a control group that did not receive any training at any location. The work highlights inherent difficulties in inves- tigating perceptual learning, which relate to the fact that learning likely takes place at both lower and higher levels of processing, however, the paradigm provides a good starting point for comprehensively investigating the complex mechanisms underlying perceptual learning.
Published: 2016

47. CMB-S4 Science Book, First Edition

Author: Abazajian, Kevork N, Adshead, Peter, Ahmed, Zeeshan, Allen, Steven W, Alonso, David, Arnold, Kam S, Baccigalupi, Carlo, Bartlett, James G, Battaglia, Nicholas, Benson, Bradford A, Bischoff, Colin A, Borrill, Julian, Buza, Victor, Calabrese, Erminia, Caldwell, Robert, Carlstrom, John E, Chang, Clarence L, Crawford, Thomas M, Cyr-Racine, Francis-Yan, Bernardis, Francesco De, Haan, Tijmen de, Alighieri, Sperello di Serego, Dunkley, Joanna, Dvorkin, Cora, Errard, Josquin, Fabbian, Giulio, Feeney, Stephen, Ferraro, Simone, Filippini, Jeffrey P, Flauger, Raphael, Fuller, George M, Gluscevic, Vera, Green, Daniel, Grin, Daniel, Grohs, Evan, Henning, Jason W, Hill, J Colin, Hlozek, Renee, Holder, Gilbert, Holzapfel, William, Hu, Wayne, Huffenberger, Kevin M, Keskitalo, Reijo, Knox, Lloyd, Kosowsky, Arthur, Kovac, John, Kovetz, Ely D, Kuo, Chao-Lin, Kusaka, Akito, Jeune, Maude Le, Lee, Adrian T, Lilley, Marc, Loverde, Marilena, Madhavacheril, Mathew S, Mantz, Adam, Marsh, David JE, McMahon, Jeffrey, Meerburg, Pieter Daniel, Meyers, Joel, Miller, Amber D, Munoz, Julian B, Nguyen, Ho Nam, Niemack, Michael D, Peloso, Marco, Peloton, Julien, Pogosian, Levon, Pryke, Clement, Raveri, Marco, Reichardt, Christian L, Rocha, Graca, Rotti, Aditya, Schaan, Emmanuel, Schmittfull, Marcel M, Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sherwin, Blake D, Smith, Tristan L, Sorbo, Lorenzo, Starkman, Glenn D, Story, Kyle T, Engelen, Alexander van, Vieira, Joaquin D, Watson, Scott, Whitehorn, Nathan, and Wu, WL Kimmy
Subjects: astro-ph.CO, gr-qc, hep-ph, hep-th
Abstract: This book lays out the scientific goals to be addressed by thenext-generation ground-based cosmic microwave background experiment, CMB-S4,envisioned to consist of dedicated telescopes at the South Pole, the highChilean Atacama plateau and possibly a northern hemisphere site, all equippedwith new superconducting cameras. CMB-S4 will dramatically advance cosmologicalstudies by crossing critical thresholds in the search for the B-modepolarization signature of primordial gravitational waves, in the determinationof the number and masses of the neutrinos, in the search for evidence of newlight relics, in constraining the nature of dark energy, and in testing generalrelativity on large scales.
Published: 2016

48. Longitudinal stability of social cognition in schizophrenia: A 5-year follow-up of social perception and emotion processing.

Author: McCleery, Amanda, Lee, Junghee, Fiske, Alan P, Ghermezi, Livon, Hayata, Jacqueline N, Hellemann, Gerhard S, Horan, William P, Kee, Kimmy S, Kern, Robert S, Knowlton, Barbara J, Subotnik, Kenneth L, Ventura, Joseph, Sugar, Catherine A, Nuechterlein, Keith H, and Green, Michael F
Subjects: Humans, Disease Progression, Linear Models, Longitudinal Studies, Follow-Up Studies, Emotions, Social Perception, Psychotic Disorders, Psychological Tests, Schizophrenic Psychology, Adult, Female, Male, Emotional Intelligence, Cross-lagged panel analyses, Illness duration, MSCEIT, Psychosis, RAD, Social cognition, Brain Disorders, Clinical Research, Serious Mental Illness, Behavioral and Social Science, Basic Behavioral and Social Science, Mental Health, Schizophrenia, Mental health, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: BackgroundIndividuals with schizophrenia exhibit marked and disproportional impairment in social cognition, which is associated with their level of community functioning. However, it is unclear whether social cognitive impairment is stable over time, or if impairment worsens as a function of illness chronicity. Moreover, little is known about the longitudinal associations between social cognition and community functioning.MethodForty-one outpatients with schizophrenia completed tests of emotion processing (Mayer-Salovey-Caruso Emotional Intelligence Test, MSCEIT) and social perception (Relationships Across Domains, RAD) at baseline and approximately five years later. Stability of performance was assessed using paired t-tests and correlations. Longitudinal associations between social cognition and community functioning (Role Functioning Scale, RFS) were assessed using cross-lagged panel correlation analysis.ResultsPerformance on the two social cognition tasks were stable over follow-up. There were no significant mean differences between assessment points [p's≥0.20, Cohen'sd's≤|0.20|], and baseline performance was highly correlated with performance at follow-up [ρ's≥0.70, ICC≥0.83, p's
Published: 2016

49. Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging

Author: Rovira-Clavé, Xavier, Jiang, Sizun, Bai, Yunhao, Zhu, Bokai, Barlow, Graham, Bhate, Salil, Coskun, Ahmet F., Han, Guojun, Ho, Chin-Min Kimmy, Hitzman, Chuck, Chen, Shih-Yu, Bava, Felice-Alessio, and Nolan, Garry P.
Published: 2021
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50. Freezing Out Early Dark Energy

Author: Bielefeld, Jannis, Wu, W. L. Kimmy, Caldwell, Robert R., and Dore, Olivier
Subjects: Astrophysics - Cosmology and Extragalactic Astrophysics, General Relativity and Quantum Cosmology
Abstract: A phenomenological model of dark energy that tracks the baryonic and cold dark matter at early times but resembles a cosmological constant at late times is explored. In the transition between these two regimes, the dark energy density drops rapidly as if it were a relic species that freezes out, during which time the equation of state peaks at +1. Such an adjustment in the dark energy density, as it shifts from scaling to potential-domination, could be the signature of a trigger mechanism that helps explain the late-time cosmic acceleration. We show that the non-negligible dark energy density at early times, and the subsequent peak in the equation of state at the transition, leave an imprint on the cosmic microwave background anisotropy pattern and the rate of growth of large scale structure. The model introduces two new parameters, consisting of the present-day equation of state and the redshift of the freeze-out transition. A Monte Carlo Markov Chain analysis of a ten-dimensional parameter space is performed to compare the model with pre-Planck cosmic microwave background, large scale structure and supernova data and measurements of the Hubble constant. We find that the transition described by this model could have taken place as late as a redshift z~400. We explore the capability of future cosmic microwave background and weak lensing experiments to put tighter constraints on this model. The viability of this model may suggest new directions in dark-energy model building that address the coincidence problem., Comment: 11 pages, 15 figures
Published: 2013
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