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1. Characteristics of cellulose nanofibril films prepared by liquid- and gas-phase esterification processes

Author

Kim Jeong-Ki, Bandi Rajkumar, Dadigala Ramakrishna, Han Song-Yi, Van Hai Le, Cho Seung-Woo, Ma Seo-Young, Lee Da-Young, Kwon Gu-Joong, and Lee Seung-Hwan

Subjects
nanocellulose, fatty acid chlorides, hydrophobicity, tensile properties, crystallinity, Polymers and polymer manufacture, TP1080-1185
Abstract

Cellulose nanofibrils (CNFs) are versatile materials, but their sensitivity to humidity affects performance. Esterification with fatty acids enhances the hydrophobicity of CNF films. This study compared gas- and liquid-phase esterification using three fatty acid chlorides at different dosages. Gas-phase esterification minimally affected cellulose crystallinity, maintaining a crystallinity index exceeding 55.8%, whereas liquid-phase esterification significantly reduced crystallinity. Gas-phase esterification achieved hydrophobicity (water contact angle >100°) with less fatty acid chlorides (0.50 eq/OH) compared to liquid-phase esterification (1.00 eq/OH). Tensile strength significantly dropped in the liquid phase (68.4–6 MPa) and up to an 8-fold decrease in the elastic modulus. Conversely, gas-phase esterification maintained tensile strength over 40 MPa, and elastic modulus increased by a minimum of 2.5 times. However, gas-phase esterification resulted in a 5-fold reduction in elongation at break (%). Thermogravimetric analysis indicated a high T max of 362°C for liquid-phase esterified samples and a substantial 24.9% residual weight for gas-phase esterified samples.

Published
2024
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10. Muscle-specific SMN reduction reveals motor neuron-independent disease in spinal muscular atrophy models

Author

Kim, Jeong-Ki, Jha, Narendra N., Feng, Zhihua, Faleiro, Michelle R., Chiriboga, Claudia A., Wei-Lapierre, Lan, Dirksen, Robert T., Ko, Chien-Ping, and Monani, Umrao R.

Subjects
Spinal muscular atrophy, Skeletal muscle, Medical research, Drug approval, Neurons, Muscular atrophy, Paralysis, Animal genetic engineering, Diseases, Health care industry, The Jackson Laboratory, Spinraza (Medication)
Abstract

Paucity of the survival motor neuron (SMN) protein triggers the oft-fatal infantile-onset motor neuron disorder, spinal muscular atrophy (SMA). Augmenting the protein is one means of treating SMA and recently led to FDA approval of an intrathecally delivered SMN-enhancing oligonucleotide currently in use. Notwithstanding the advent of this and other therapies for SMA, it is unclear whether the paralysis associated with the disease derives solely from dysfunctional motor neurons that may be efficiently targeted by restricted delivery of SMN-enhancing agents to the nervous system, or stems from broader defects of the motor unit, arguing for systemic SMN repletion. We investigated the disease-contributing effects of low SMN in one relevant peripheral organ--skeletal muscle--by selectively depleting the protein in only this tissue. We found that muscle deprived of SMN was profoundly damaged. Although a disease phenotype was not immediately obvious, persistent low levels of the protein eventually resulted in muscle fiber defects, neuromuscular junction abnormalities, compromised motor performance, and premature death. Importantly, restoring SMN after the onset of muscle pathology reversed disease. Our results provide the most compelling evidence yet for a direct contributing role of muscle in SMA and argue that an optimal therapy for the disease must be designed to treat this aspect of the dysfunctional motor unit., Introduction Homozygous mutations in the survival of motor neuron 1 (SMN1) gene result in reduced levels of the SMN protein and trigger the infantile-onset neuromuscular disease, spinal muscular atrophy (SMA) [...]

Published
2020
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30. Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

Author

Kim, Jeong-Ki, Kayali, Ghazi, Walker, David, Forrest, Heather L., Ellebedy, Ali H., Griffin, Yolanda S., Rubrum, Adam, Bahgat, Mahmoud M., Kutkat, M. A., Ali, M. A. A., Aldridge, Jerry R., Negovetich, Nicholas J., Krauss, Scott, Webby, Richard J., and Webster, Robert G.

Published
2010

32. Efficient Anti-Tumor Immunotherapy Using Tumor Epitope-Coated Biodegradable Nanoparticles Combined With Polyinosinic-Polycytidylic Acid and an Anti-PD1 Monoclonal Antibody

Author

Kim, Sang-Hyun, primary, Park, Ji-Hyun, additional, Lee, Sun-Jae, additional, Lee, Hee-Sung, additional, Jung, Jae-Kyung, additional, Lee, Young-Ran, additional, Cho, Hyun-Il, additional, Kim, Jeong-Ki, additional, Kim, Kyungjae, additional, Park, Chan-Su, additional, and Lee, Chong-Kil, additional

Published
2022
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33. Effects of Statin Combinations on Zika Virus Infection in Vero Cells.

Author

Españo, Erica and Kim, Jeong-Ki

Subjects
*ZIKA virus infections, *STATINS (Cardiovascular agents), *ZIKA virus, *FRACTIONS, *FLUVASTATIN
Abstract

The Zika virus (ZIKV) remains a global health concern. Thus far, no antiviral or vaccine has been approved to prevent or treat ZIKV infection. In a previous study, we found that lipophilic statins can inhibit ZIKV production in Vero cells. These statins appear to have different potencies against ZIKV infection. Here, we determined whether combinations of statins would have synergistic effects to maximize the efficacy of the statins and to reduce potential side effects. Specifically, we used a modified fixed-ratio assay for the combinations of atorvastatin (ATO) or fluvastatin (FLU) with mevastatin (MEV) or simvastatin (SIM). All combinations with MEV tended towards synergy, especially with higher fractions of MEV in the combinations. The ATO + SIM combination tended towards additivity. The FLU + SIM combination also tended towards additivity except for one combination which had the highest fraction of FLU over SIM among the tested combinations. Overall, certain combinations of ATO or FLU with SIM or MEV may be synergistic. More exhaustive combinatorial assays in vitro and in vivo could help define whether combining lipophilic statins would be beneficial and safe for treating ZIKV infections. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Wet-Spun Composite Filaments from Lignocellulose Nanofibrils/Alginate and Their Physico-Mechanical Properties

Author

Park, Ji-Soo, primary, Han, Song-Yi, additional, Bandi, Rajkumar, additional, Lee, Eun-Ah, additional, Cindradewi, Azelia-Wulan, additional, Kim, Jeong-Ki, additional, Kwon, Gu-Joong, additional, Seo, Young-Ho, additional, Youe, Won-Jae, additional, Gwon, Jaegyoung, additional, Park, Chan-Woo, additional, and Lee, Seung-Hwan, additional

Published
2021
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41. Extensive mammalian ancestry of pandemic (H1N1) 2009 virus

Author

Ilyushina, Natalia A., Kim, Jeong-Ki, Negovetich, Nicholas J., Choi, Young-Ki, Lang, Victoria, Bovin, Nicolai V., Forrest, Heather L., Song, Min-Suk, Pascua, Philippe Noriel Q., Kim, Chul-Joong, Webster, Robert G., and Webby, Richard J.

Subjects
Viruses -- Receptors, Swine influenza -- Risk factors -- Control -- Research, Influenza viruses -- Health aspects -- Research, Health
Abstract

In 2009, a new H1N1 influenza virus (pandemic [H1N1] 2009) emerged in Mexico, spread to the United States (1), and subsequently caused the first influenza pandemic of the 21st century [...]

Published
2010
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