Search

Your search keyword '"Khaw, Peng"' showing total 391 results
Start Over Author "Khaw, Peng" Search Limiters Full Text
391 results on '"Khaw, Peng"'

2. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.

Author

Gharahkhani, Puya, Jorgenson, Eric, Hysi, Pirro, Khawaja, Anthony P, Pendergrass, Sarah, Han, Xikun, Ong, Jue Sheng, Hewitt, Alex W, Segrè, Ayellet V, Rouhana, John M, Hamel, Andrew R, Igo, Robert P, Choquet, Helene, Qassim, Ayub, Josyula, Navya S, Cooke Bailey, Jessica N, Bonnemaijer, Pieter WM, Iglesias, Adriana, Siggs, Owen M, Young, Terri L, Vitart, Veronique, Thiadens, Alberta AHJ, Karjalainen, Juha, Uebe, Steffen, Melles, Ronald B, Nair, K Saidas, Luben, Robert, Simcoe, Mark, Amersinghe, Nishani, Cree, Angela J, Hohn, Rene, Poplawski, Alicia, Chen, Li Jia, Rong, Shi-Song, Aung, Tin, Vithana, Eranga Nishanthie, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Tamiya, Gen, Shiga, Yukihiro, Yamamoto, Masayuki, Nakazawa, Toru, Currant, Hannah, Birney, Ewan, Wang, Xin, Auton, Adam, Lupton, Michelle K, Martin, Nicholas G, Ashaye, Adeyinka, Olawoye, Olusola, Williams, Susan E, Akafo, Stephen, Ramsay, Michele, Hashimoto, Kazuki, Kamatani, Yoichiro, Akiyama, Masato, Momozawa, Yukihide, Foster, Paul J, Khaw, Peng T, Morgan, James E, Strouthidis, Nicholas G, Kraft, Peter, Kang, Jae H, Pang, Chi Pui, Pasutto, Francesca, Mitchell, Paul, Lotery, Andrew J, Palotie, Aarno, van Duijn, Cornelia, Haines, Jonathan L, Hammond, Chris, Pasquale, Louis R, Klaver, Caroline CW, Hauser, Michael, Khor, Chiea Chuen, Mackey, David A, Kubo, Michiaki, Cheng, Ching-Yu, Craig, Jamie E, MacGregor, Stuart, and Wiggs, Janey L

Subjects
NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, and Me Research Team, Humans, Glaucoma, Open-Angle, Genetic Predisposition to Disease, Genotype, Polymorphism, Single Nucleotide, Asian Continental Ancestry Group, European Continental Ancestry Group, Genome-Wide Association Study, Genetic Loci, Glaucoma, Open-Angle, Polymorphism, Single Nucleotide
Abstract

Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects across European, Asian and African ancestries. Cross-ancestry data improve fine-mapping of causal variants for several loci. Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential contributions of several genes to POAG pathogenesis, including SVEP1, RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6. Several drug compounds targeting POAG risk genes may be potential glaucoma therapeutic candidates.

Published
2021

3. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Author

Bailey-Wilson, Joan E., Baird, Paul N., Barathi, Veluchamy A., Biino, Ginevra, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching-Yu, Chew, Emily Y., Craig, Jamie E., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Haarman, Annechien E.G., Haller, Toomas, Hammond, Christopher J., Han, Xikun, Hayward, Caroline, He, Mingguang, Hewitt, Alex W., Hoang, Quan, Hysi, Pirro G., Iglesias, Adriana I., Igo, Robert P., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Khawaja, Anthony P., Klein, Barbara E., Lass, Jonathan H., Lee, Kris, Lehtimäki, Terho, Lewis, Deyana, Li, Qing, Li, Shi-Ming, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mackey, David A., Martin, Nicholas G., Meguro, Akira, Metspalu, Andres, Middlebrooks, Candace, Miyake, Masahiro, Mizuki, Nobuhisa, Musolf, Anthony, Nickels, Stefan, Oexle, Konrad, Pang, Chi Pui, Pärssinen, Olavi, Paterson, Andrew D., Pfeiffer, Norbert, Polasek, Ozren, Rahi, Jugnoo S., Raitakari, Olli, Rudan, Igor, Sahebjada, Srujana, Saw, Seang-Mei, Simpson, Claire L., Stambolian, Dwight, Tai, E-Shyong, Tedja, Milly S., Tideman, J. Willem L., Tsujikawa, Akitaka, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Vitart, Veronique, Wang, Ningli, Wang, Ya Xing, Wedenoja, Juho, Wei, Wen Bin, Williams, Cathy, Williams, Katie M., Wilson, James F., Wojciechowski, Robert, Yam, Jason C.S., Yamashiro, Kenji, Yap, Maurice K.H., Yazar, Seyhan, Yip, Shea Ping, Young, Terri L., Zhou, Xiangtian, Allen, Naomi, Aslam, Tariq, Atan, Denize, Barman, Sarah, Barrett, Jenny, Bishop, Paul, Black, Graeme, Bunce, Catey, Carare, Roxana, Chakravarthy, Usha, Chan, Michelle, Chua, Sharon, Cipriani, Valentina, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew, Doney, Alexander, Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John, Garway-Heath, David, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy, Hammond, Chris, Hardcastle, Alison, Harding, Simon, Hogg, Ruth, Hysi, Pirro, Keane, Pearse A., Khaw, Peng Tee, Khawaja, Anthony, Lascaratos, Gerassimos, Littlejohns, Thomas, Lotery, Andrew, Luthert, Phil, MacGillivray, Tom, Mackie, Sarah, McGuinness, Bernadette, McKay, Gareth, McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James, Muthy, Zaynah, O'Sullivan, Eoin, Owen, Chris, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Pontikos, Nikolas, Rahi, Jugnoo, Rudnicka, Alicja, Self, Jay, Sergouniotis, Panagiotis, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Tapp, Robyn, Thaung, Caroline, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vernon, Stephen, Viswanathan, Ananth, Williams, Katie, Woodside, Jayne, Yates, Max, Yip, Jennifer, Zheng, Yalin, Clark, Rosie, Lee, Samantha Sze-Yee, Du, Ran, Wang, Yining, Kneepkens, Sander C.M., Charng, Jason, Huang, Yu, Hunter, Michael L., Jiang, Chen, Tideman, J.Willem L., Melles, Ronald B., Klaver, Caroline C.W., Choquet, Hélène, and Ohno-Matsui, Kyoko

Published
2023
Full Text
View/download PDF

6. Study of Optimal Perimetric Testing in Children (OPTIC): evaluation of kinetic approaches in childhood neuro-ophthalmic disease

Author

Patel, Dipesh E, Cumberland, Phillippa M, Walters, Bronwen C, Cortina-Borja, Mario, Rahi, Jugnoo S, Khaw, Peng Tee, Walters, Bronwen, Russell-Eggitt, Isabelle, Timms, Chris, Brookes, John, Moore, Anthony, Papadopoulos, Maria, Garway-Heath, David, Viswanathan, Ananth, Liasis, Alki, and Crabb, David

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Pediatric, Neurosciences, Clinical Research, Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Feasibility Studies, Female, Follow-Up Studies, Humans, Infant, Male, Prospective Studies, Reproducibility of Results, Vision Disorders, Visual Acuity, Visual Field Tests, Visual Fields, OPTIC study group, child health, diagnostic tests/investigation, field of vision, visual pathway, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Clinical sciences, Ophthalmology and optometry
Abstract

AimsWe compared feasibility, quality and outcomes of visual field (VF) testing in children with neuro-ophthalmic disease between the discontinued 'gold-standard' Goldmann and Octopus perimeters.MethodsChildren with neuro-ophthalmic disease, attending Great Ormond Street Hospital, London, were assessed using standardised protocols by one examiner in a single sitting, using Goldmann and Octopus kinetic perimetry. Outputs were classified to compare severity of loss and defect type. Test quality was assessed using both qualitative and quantitative methods.ResultsThirty children (40% female) aged 5-15 years participated. Goldmann perimetry was completed in full by 90.0% vs 72.4% for Octopus. Inability to plot the blind spot was the most common reason for not completing testing. Over 75% completed a test in ≤20 min. Duration was similar between perimeters (paired t-test, mean difference: 0.48min (-1.2, 2.2), p=0.559). The lowest quality tests were for Octopus perimetry in children

Published
2019

8. The Lancet Global Health Commission on Global Eye Health: vision beyond 2020

Author

Burton, Matthew J, Ramke, Jacqueline, Marques, Ana Patricia, Bourne, Rupert R A, Congdon, Nathan, Jones, Iain, Ah Tong, Brandon A M, Arunga, Simon, Bachani, Damodar, Bascaran, Covadonga, Bastawrous, Andrew, Blanchet, Karl, Braithwaite, Tasanee, Buchan, John C, Cairns, John, Cama, Anasaini, Chagunda, Margarida, Chuluunkhuu, Chimgee, Cooper, Andrew, Crofts-Lawrence, Jessica, Dean, William H, Denniston, Alastair K, Ehrlich, Joshua R, Emerson, Paul M, Evans, Jennifer R, Frick, Kevin D, Friedman, David S, Furtado, João M, Gichangi, Michael M, Gichuhi, Stephen, Gilbert, Suzanne S, Gurung, Reeta, Habtamu, Esmael, Holland, Peter, Jonas, Jost B, Keane, Pearse A, Keay, Lisa, Khanna, Rohit C, Khaw, Peng Tee, Kuper, Hannah, Kyari, Fatima, Lansingh, Van C, Mactaggart, Islay, Mafwiri, Milka M, Mathenge, Wanjiku, McCormick, Ian, Morjaria, Priya, Mowatt, Lizette, Muirhead, Debbie, Murthy, Gudlavalleti V S, Mwangi, Nyawira, Patel, Daksha B, Peto, Tunde, Qureshi, Babar M, Salomão, Solange R, Sarah, Virginia, Shilio, Bernadetha R, Solomon, Anthony W, Swenor, Bonnielin K, Taylor, Hugh R, Wang, Ningli, Webson, Aubrey, West, Sheila K, Wong, Tien Yin, Wormald, Richard, Yasmin, Sumrana, Yusufu, Mayinuer, Silva, Juan Carlos, Resnikoff, Serge, Ravilla, Thulasiraj, Gilbert, Clare E, Foster, Allen, and Faal, Hannah B

Published
2021
Full Text
View/download PDF

9. Do visually impaired children and their parents agree on the child's vision-related quality of life and functional vision?

Author

Tadić, Valerija, Cumberland, Phillippa M, Lewando-Hundt, Gillian, Rahi, Jugnoo S, Dale, Naomi, Khaw, Peng Tee, Moore, Anthony, Salt, Alison, Taylor, David, Brown, Corie, Craig, Marianne, Ennals, Christine, Keeley, Sarah, Thompson, Lucy, Osborne, Jackie, Sobti, Nidhi, Thomas, Paula, and Thompson, Jude

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Eye Disease and Disorders of Vision, Pediatric, Neurosciences, Clinical Research, Eye, Adolescent, Adult, Child, Female, Health Status, Humans, Parent-Child Relations, Parents, Quality of Life, Sickness Impact Profile, Surveys and Questionnaires, Vision Disorders, Vision, Ocular, Visual Acuity, Visually Impaired Persons, vision-related quality of life group, Child health, Epidemiology, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Clinical sciences, Ophthalmology and optometry
Abstract

AimsTo investigate agreement between children with visual impairment (VI) and their parents on their ratings of the child's vision-related quality of life (VQoL) and functional vision (FV) using two novel self-report patient-reported outcome measures developed for this population.Methods99 children aged 10-15 years (mean age=12.2, SD=1.9) with VI (best corrected acuity (logarithm of the minimum angle of resolution) 0.50 or worse in better eye) and their parents participated in a national postal survey, completing the child and proxy versions of our novel instruments assessing VQoL and FV of children with VI-the vision-related quality of life instrument for children and young people (VQoL_CYP) and the functional vision questionnaire for children and young people (FVQ_CYP), respectively. Parent-child agreement was investigated using the Bland-Altman (BA) method. Variation across key sociodemographic and clinical characteristics was examined using the Intraclass Correlation Coefficient.ResultsAverage parental ratings of their child's VQoL and FV were significantly lower than the children's own ratings, but the range of disagreement was wide, with parents both overestimating and underestimating their child's VQoL (mean score difference=5.7, BA limits of agreement (LOA): lower -22.10 (CI 95% -24.61 to 19.59) and upper 33.50 (CI 95% 30.99 to 36.01)), but more consistently underestimating the child's FV (mean score difference=-11.8, BA LOA: lower -39.60 (CI 95% -42.12 to 37.08) and upper 16 (CI 95% 13.48 to 18.52)). There was variation in agreement by some child characteristics, including vision level, time of onset and course of VI progression.ConclusionsVisually impaired children and their parents perceive the broader impact of living with VI very differently. There is value in routine capture of information independently from children and their parents for comprehensively gauging the impact of childhood VI and tailoring appropriate interventions.

Published
2017

10. Structural correlations between brain magnetic resonance image‐derived phenotypes and retinal neuroanatomy.

Author

Sun, Zihan, Zhang, Bing, Smith, Stephen, Atan, Denize, Khawaja, Anthony P., Stuart, Kelsey V., Luben, Robert N., Biradar, Mahantesh I., McGillivray, Thomas, Patel, Praveen J., Khaw, Peng T., Petzold, Axel, and Foster, Paul J.

Subjects
NEUROANATOMY, MAGNETIC resonance, PHENOTYPES, OPTICAL coherence tomography, MAGNETIC resonance imaging
Abstract

Background and purpose: The eye is a well‐established model of brain structure and function, yet region‐specific structural correlations between the retina and the brain remain underexplored. Therefore, we aim to explore and describe the relationships between the retinal layer thicknesses and brain magnetic resonance image (MRI)‐derived phenotypes in UK Biobank. Methods: Participants with both quality‐controlled optical coherence tomography (OCT) and brain MRI were included in this study. Retinal sublayer thicknesses and total macular thickness were derived from OCT scans. Brain image‐derived phenotypes (IDPs) of 153 cortical and subcortical regions were processed from MRI scans. We utilized multivariable linear regression models to examine the association between retinal thickness and brain regional volumes. All analyses were corrected for multiple testing and adjusted for confounders. Results: Data from 6446 participants were included in this study. We identified significant associations between volumetric brain MRI measures of subregions in the occipital lobe (intracalcarine cortex), parietal lobe (postcentral gyrus), cerebellum (lobules VI, VIIb, VIIIa, VIIIb, and IX), and deep brain structures (thalamus, hippocampus, caudate, putamen, pallidum, and accumbens) and the thickness of the innermost retinal sublayers and total macular thickness (all p < 3.3 × 10−5). We did not observe statistically significant associations between brain IDPs and the thickness of the outer retinal sublayers. Conclusions: Thinner inner and total retinal thicknesses are associated with smaller volumes of specific brain regions. Notably, these relationships extend beyond anatomically established retina–brain connections. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Predicting conversion to wet age-related macular degeneration using deep learning

Author

Yim, Jason, Chopra, Reena, Spitz, Terry, Winkens, Jim, Obika, Annette, Kelly, Christopher, Askham, Harry, Lukic, Marko, Huemer, Josef, Fasler, Katrin, Moraes, Gabriella, Meyer, Clemens, Wilson, Marc, Dixon, Jonathan, Hughes, Cian, Rees, Geraint, Khaw, Peng T., Karthikesalingam, Alan, King, Dominic, Hassabis, Demis, Suleyman, Mustafa, Back, Trevor, Ledsam, Joseph R., Keane, Pearse A., and De Fauw, Jeffrey

Published
2020
Full Text
View/download PDF

16. Cell-Based Therapies for Glaucoma

Author

Luis, Joshua, primary, Eastlake, Karen, additional, Lamb, William D. B., additional, Limb, G. Astrid, additional, Jayaram, Hari, additional, and Khaw, Peng T., additional

Published
2023
Full Text
View/download PDF

19. Clinically applicable deep learning for diagnosis and referral in retinal disease

Author

De Fauw, Jeffrey, Ledsam, Joseph R., Romera-Paredes, Bernardino, Nikolov, Stanislav, Tomasev, Nenad, Blackwell, Sam, Askham, Harry, Glorot, Xavier, O’Donoghue, Brendan, Visentin, Daniel, van den Driessche, George, Lakshminarayanan, Balaji, Meyer, Clemens, Mackinder, Faith, Bouton, Simon, Ayoub, Kareem, Chopra, Reena, King, Dominic, Karthikesalingam, Alan, Hughes, Cían O., Raine, Rosalind, Hughes, Julian, Sim, Dawn A., Egan, Catherine, Tufail, Adnan, Montgomery, Hugh, Hassabis, Demis, Rees, Geraint, Back, Trevor, Khaw, Peng T., Suleyman, Mustafa, Cornebise, Julien, Keane, Pearse A., and Ronneberger, Olaf

Published
2018
Full Text
View/download PDF

20. Real-Time Monitoring Platform for Ocular Drug Delivery

Author

Awwad, Sahar, primary, Ibeanu, Nkiruka, additional, Liu, Tianyang, additional, Velentza-Almpani, Angeliki, additional, Chouhan, Nerisha, additional, Vlatakis, Stavros, additional, Khaw, Peng Tee, additional, Brocchini, Steve, additional, and Bouremel, Yann, additional

Published
2023
Full Text
View/download PDF

21. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Author

Clark, Rosie, primary, Lee, Samantha Sze-Yee, additional, Du, Ran, additional, Wang, Yining, additional, Kneepkens, Sander C.M., additional, Charng, Jason, additional, Huang, Yu, additional, Hunter, Michael L., additional, Jiang, Chen, additional, Tideman, J.Willem L., additional, Melles, Ronald B., additional, Klaver, Caroline C.W., additional, Mackey, David A., additional, Williams, Cathy, additional, Choquet, Hélène, additional, Ohno-Matsui, Kyoko, additional, Guggenheim, Jeremy A., additional, Bailey-Wilson, Joan E., additional, Baird, Paul N., additional, Barathi, Veluchamy A., additional, Biino, Ginevra, additional, Burdon, Kathryn P., additional, Campbell, Harry, additional, Chen, Li Jia, additional, Cheng, Ching-Yu, additional, Chew, Emily Y., additional, Craig, Jamie E., additional, Deangelis, Margaret M., additional, Delcourt, Cécile, additional, Ding, Xiaohu, additional, Fan, Qiao, additional, Fossarello, Maurizio, additional, Foster, Paul J., additional, Gharahkhani, Puya, additional, Guo, Xiaobo, additional, Haarman, Annechien E.G., additional, Haller, Toomas, additional, Hammond, Christopher J., additional, Han, Xikun, additional, Hayward, Caroline, additional, He, Mingguang, additional, Hewitt, Alex W., additional, Hoang, Quan, additional, Hysi, Pirro G., additional, Iglesias, Adriana I., additional, Igo, Robert P., additional, Iyengar, Sudha K., additional, Jonas, Jost B., additional, Kähönen, Mika, additional, Kaprio, Jaakko, additional, Khawaja, Anthony P., additional, Klein, Barbara E., additional, Lass, Jonathan H., additional, Lee, Kris, additional, Lehtimäki, Terho, additional, Lewis, Deyana, additional, Li, Qing, additional, Li, Shi-Ming, additional, Lyytikäinen, Leo-Pekka, additional, MacGregor, Stuart, additional, Martin, Nicholas G., additional, Meguro, Akira, additional, Metspalu, Andres, additional, Middlebrooks, Candace, additional, Miyake, Masahiro, additional, Mizuki, Nobuhisa, additional, Musolf, Anthony, additional, Nickels, Stefan, additional, Oexle, Konrad, additional, Pang, Chi Pui, additional, Pärssinen, Olavi, additional, Paterson, Andrew D., additional, Pfeiffer, Norbert, additional, Polasek, Ozren, additional, Rahi, Jugnoo S., additional, Raitakari, Olli, additional, Rudan, Igor, additional, Sahebjada, Srujana, additional, Saw, Seang-Mei, additional, Simpson, Claire L., additional, Stambolian, Dwight, additional, Tai, E-Shyong, additional, Tedja, Milly S., additional, Tideman, J. Willem L., additional, Tsujikawa, Akitaka, additional, van Duijn, Cornelia M., additional, Verhoeven, Virginie J.M., additional, Vitart, Veronique, additional, Wang, Ningli, additional, Wang, Ya Xing, additional, Wedenoja, Juho, additional, Wei, Wen Bin, additional, Williams, Katie M., additional, Wilson, James F., additional, Wojciechowski, Robert, additional, Yam, Jason C.S., additional, Yamashiro, Kenji, additional, Yap, Maurice K.H., additional, Yazar, Seyhan, additional, Yip, Shea Ping, additional, Young, Terri L., additional, Zhou, Xiangtian, additional, Allen, Naomi, additional, Aslam, Tariq, additional, Atan, Denize, additional, Barman, Sarah, additional, Barrett, Jenny, additional, Bishop, Paul, additional, Black, Graeme, additional, Bunce, Catey, additional, Carare, Roxana, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chua, Sharon, additional, Cipriani, Valentina, additional, Day, Alexander, additional, Desai, Parul, additional, Dhillon, Bal, additional, Dick, Andrew, additional, Doney, Alexander, additional, Egan, Cathy, additional, Ennis, Sarah, additional, Foster, Paul, additional, Fruttiger, Marcus, additional, Gallacher, John, additional, Garway-Heath, David, additional, Gibson, Jane, additional, Gore, Dan, additional, Guggenheim, Jeremy, additional, Hammond, Chris, additional, Hardcastle, Alison, additional, Harding, Simon, additional, Hogg, Ruth, additional, Hysi, Pirro, additional, Keane, Pearse A., additional, Khaw, Peng Tee, additional, Khawaja, Anthony, additional, Lascaratos, Gerassimos, additional, Littlejohns, Thomas, additional, Lotery, Andrew, additional, Luthert, Phil, additional, MacGillivray, Tom, additional, Mackie, Sarah, additional, McGuinness, Bernadette, additional, McKay, Gareth, additional, McKibbin, Martin, additional, Mitry, Danny, additional, Moore, Tony, additional, Morgan, James, additional, Muthy, Zaynah, additional, O'Sullivan, Eoin, additional, Owen, Chris, additional, Patel, Praveen, additional, Paterson, Euan, additional, Peto, Tunde, additional, Petzold, Axel, additional, Pontikos, Nikolas, additional, Rahi, Jugnoo, additional, Rudnicka, Alicja, additional, Self, Jay, additional, Sergouniotis, Panagiotis, additional, Sivaprasad, Sobha, additional, Steel, David, additional, Stratton, Irene, additional, Strouthidis, Nicholas, additional, Sudlow, Cathie, additional, Tapp, Robyn, additional, Thaung, Caroline, additional, Thomas, Dhanes, additional, Trucco, Emanuele, additional, Tufail, Adnan, additional, Vernon, Stephen, additional, Viswanathan, Ananth, additional, Williams, Katie, additional, Woodside, Jayne, additional, Yates, Max, additional, Yip, Jennifer, additional, and Zheng, Yalin, additional

Published
2023
Full Text
View/download PDF

22. The effects of growth factors and antiproliferative agents on ocular fibroblasts and wound healing after glaucoma filtration surgery

Author

Khaw, Peng Tee

Subjects
610, Blindness, Ophthalmology
Abstract

Glaucoma (visual damage associated with raised intraocular pressure) is a major cause of worldwide blindness. The most effective treatment for glaucoma is filtration surgery, but the major cause of failure and suboptimal lowering of the intraocular pressure is scarring at the site of the surgery. In this thesis, I investigated the role of stimulatory molecules found in aqueous humour, and the effects of antiproliferative agents on ocular fibroblasts. Fibronectin levels were found to be significantly raised in the aqueous of patients with glaucoma, but the chemoattractant activity of the aqueous was not. All growth factors tested stimulated proliferation, migration and collagen production, but transforming growth factor-β1 stimulated proliferation, migration and proline uptake at much lower concentrations than the other growth factors (epidermal, basic fibroblast and insulin-like growth factor-1). Following treatments with antiproliferative agents ocular fibroblasts could be growth arrested for periods much longer than previously thought, suggesting that single short treatments with these agents would inhibit fibroblast proliferation in the long term. The animal model results confirmed the in vitro findings with 5 minute applications of antiproliferative agents. Long term titratable effects on wound healing were shown in an experimental model of wound healing after glaucoma filtration surgery. The effects were focal and confined to the treated areas. Cells growth arrested by treatment could still be stimulated to increase RNA levels after stimulation with TGF-β1. The experiments in this thesis have shown that growth factors present in the aqueous can have profound effects on the proliferation, migration and collagen production of ocular fibroblasts. In addition, the studies have led to a new understanding of the long term effects of short exposures to antiproliferative agents in vitro and in vivo, particularly that long term growth arrest can be induced and this effect can be localised, and can be varied to some degree. Finally, fibroblasts can still respond to growth factors despite being growth arrested.

Published
1995

27. Transcriptomics of CD29+/CD44+ cells isolated from hPSC retinal organoids reveals a single cell population with retinal progenitor and Müller glia characteristics.

Author

Eastlake, Karen, Luis, Joshua, Wang, Weixin, Lamb, William, Khaw, Peng T., and Limb, G. Astrid

Subjects
CELL populations, ORGANOIDS, RETINAL diseases, GENE expression, RETINA
Abstract

Müller glia play very important and diverse roles in retinal homeostasis and disease. Although much is known of the physiological and morphological properties of mammalian Müller glia, there is still the need to further understand the profile of these cells during human retinal development. Using human embryonic stem cell-derived retinal organoids, we investigated the transcriptomic profiles of CD29+/CD44+ cells isolated from early and late stages of organoid development. Data showed that these cells express classic markers of retinal progenitors and Müller glia, including NFIX, RAX, PAX6, VSX2, HES1, WNT2B, SOX, NR2F1/2, ASCL1 and VIM, as early as days 10–20 after initiation of retinal differentiation. Expression of genes upregulated in CD29+/CD44+ cells isolated at later stages of organoid development (days 50–90), including NEUROG1, VSX2 and ASCL1 were gradually increased as retinal organoid maturation progressed. Based on the current observations that CD24+/CD44+ cells share the characteristics of early and late-stage retinal progenitors as well as of mature Müller glia, we propose that these cells constitute a single cell population that upon exposure to developmental cues regulates its gene expression to adapt to functions exerted by Müller glia in the postnatal and mature retina. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

28. Grand Challenges in global eye health: a global prioritisation process using Delphi method

Author

Ramke, Jacqueline, primary, Evans, Jennifer R, additional, Habtamu, Esmael, additional, Mwangi, Nyawira, additional, Silva, Juan Carlos, additional, Swenor, Bonnielin K, additional, Congdon, Nathan, additional, Faal, Hannah B, additional, Foster, Allen, additional, Friedman, David S, additional, Gichuhi, Stephen, additional, Jonas, Jost B, additional, Khaw, Peng T, additional, Kyari, Fatima, additional, Murthy, Gudlavalleti V S, additional, Wang, Ningli, additional, Wong, Tien Y, additional, Wormald, Richard, additional, Yusufu, Mayinuer, additional, Taylor, Hugh, additional, Resnikoff, Serge, additional, West, Sheila K, additional, Burton, Matthew J, additional, Aghaji, Ada, additional, Adewole, Adeyemi T, additional, Csutak, Adrienne, additional, Salam, Ahmad Shah, additional, Paduca, Ala, additional, Bron, Alain M, additional, Denniston, Alastair K, additional, Lazo Legua, Alberto, additional, Halim, Aldiana, additional, Tefera, Alemayehu Woldeyes, additional, Mwangi, Alice, additional, Jenkins, Alicia J, additional, Davis, Amanda, additional, Meddeb-Ouertani, Amel, additional, Wali, Amina H, additional, Palis, Ana G, additional, Bastos de Carvalho, Ana, additional, Joshi, Anagha, additional, Kreis, Andreas J, additional, Mueller, Andreas, additional, Bastawrous, Andrew, additional, Cooper, Andrew, additional, Smith, Andrew F, additional, Grzybowski, Andrzej, additional, Arvind, Anitha, additional, Karanu, Anne M, additional, Orlina, Anne O, additional, Burnett, Anthea, additional, Yashadhana, Aryati, additional, Abeydeera, Asela P, additional, Abdurakhmanova, Aselia, additional, Mohamed, Ashik, additional, Bacchav, Ashish, additional, Bernhisel, Ashlie, additional, Webson, Aubrey Walton, additional, Azuara-Blanco, Augusto, additional, Hossain, Ava, additional, Ilhan, Bayazit, additional, Assumpta Lucienne, Bella, additional, Tousignant, Benoit, additional, Shamanna, Bindiganavale R, additional, Wiafe, Boateng, additional, Mueller, Brigitte, additional, Caglar, Cagatay, additional, Mpyet, Caleb, additional, Abraham, Carl H, additional, Cheung, Carol Y, additional, Thiel, Cassandra L, additional, Jan, Catherine L, additional, Emedike, Chike, additional, Chuluunkhuu, Chimgee, additional, Chinyere, Chinomso, additional, Henein, Christin, additional, Gilbert, Clare E, additional, Bascaran, Covadonga, additional, Nitulescu, Cristina Elena, additional, Patel, Daksha, additional, Bachani, Damodar, additional, Kiage, Daniel, additional, Etya'ale, Daniel, additional, Dahdal, David, additional, Woo Lawson, Dawn, additional, Godin, Denise, additional, Nkanga, Dennis G, additional, Ondeyo, Dennis M, additional, O'Brien, Donna, additional, Mutie, Dorothy M, additional, Alalawi, Ebtisam S K, additional, Mayorga, Eduardo, additional, Bin Hashim, Effendy, additional, Ashrafi, Elham, additional, Kishiki, Elizabeth Andrew, additional, Kurian, Elizabeth, additional, D'Esposito, Fabrizio, additional, Masila, Faith, additional, Pena, Fernando Yaacov, additional, Büsch, Fortunat, additional, Topouzis, Fotis, additional, Bandello, Francesco, additional, Oyediji, Funmilayo J, additional, Thumann, Gabriele, additional, Ezz Elarab, Gamal, additional, Kitema, Gatera Fiston, additional, Schlenther, Gerhard, additional, Fefoame, Gertrude Oforiwa, additional, Cochrane, Gillian M, additional, Laganovska, Guna, additional, Awan, Haroon R, additional, Ansari, Harris M, additional, Philippin, Heiko, additional, Burn, Helen, additional, Dimaras, Helen, additional, Filipe, Helena P, additional, Monye, Henrietta I, additional, Kandel, Himal, additional, Randrianarisoa, Hoby Lalaina, additional, Jones, Iain, additional, Murdoch, Ian E, additional, Fabian, Ido Didi, additional, Khan, Imran A, additional, Sharma, Indra P, additional, Elbeih, Islam, additional, Mactaggart, Islay, additional, Pastor, J Carlos, additional, Keunen, Jan E E, additional, Ohuma, Jane A, additional, Pithuwa Nirwoth, Jason, additional, Hammou, Jaouad, additional, Vianna, Jayme R, additional, Biao, Jean-eudes, additional, Burr, Jennifer M, additional, Keenan, Jeremy D, additional, Blijkers, Jess, additional, Black, Joanna M, additional, Barbosa Breda, Joao, additional, Furtado, Joao M, additional, Buchan, John C, additional, Lawrenson, John G, additional, Kempen, John H, additional, Ehrlich, Joshua R, additional, Stern, Judith, additional, Zhang, Justine H, additional, Keskinbora, Kadircan H, additional, Knoll, Karin M, additional, Blanchet, Karl, additional, Schmid, Katrina L, additional, Ono, Koichi, additional, Ogundimu, Kolawole, additional, Balo, Komi, additional, Somda, Kussome Paulin, additional, Yeboah, Kwame, additional, Amissah-Arthur, Kwesi N, additional, Nasehi, Leone, additional, Øverland, Lene, additional, Vijaya, Lingam, additional, Keay, Lisa, additional, Hamm, Lisa M, additional, Mowatt, Lizette, additional, Harrison-Williams, Lloyd C M, additional, Silva, Lucia, additional, Bilotto, Luigi, additional, Mörchen, Manfred, additional, Rabiu, Mansur, additional, Zondervan, Marcia, additional, Chagunda, Margarida, additional, Sandinha, Maria Teresa, additional, Yee Melgar, Mariano, additional, Salas Vargas, Marisela, additional, Daniell, Mark D, additional, Katibeh, Marzieh, additional, Broom, Matt, additional, Collins, Megan E, additional, Alp, Mehmet Numan, additional, Kwarteng, Michael A, additional, Belkin, Michael, additional, Gichangi, Michael, additional, Sylvanowicz, Michelle, additional, Wu, Min, additional, Cano, Miriam R, additional, Shalaby, Mohammad, additional, Duggal, Mona, additional, Khairallah, Moncef, additional, Batur, Muhammed, additional, Bikbov, Mukharram M, additional, Ramappa, Muralidhar, additional, Pamarathi, Nagaraju, additional, Khachatryan, Naira, additional, Muhammad, Nasiru, additional, Kennedy, Neil, additional, Murray, Neil, additional, Beare, Nicholas A V, additional, Astbury, Nick, additional, Carnt, Nicole A, additional, St Rose, Nigel A, additional, Barker, Nigel H, additional, Pehere, Niranjan K, additional, Uche, Nkechinyere J, additional, Lois, Noemi, additional, Awe, Oluwaseun O, additional, Mujica, Oscar J, additional, Okolo, Oteri E, additional, Rani, Padmaja Kumari, additional, Ruamviboonsuk, Paisan, additional, Ndiaye, Papa Amadou, additional, Dhakhwa, Parami, additional, Rozsival, Pavel, additional, Mbulawa, Pearl K, additional, Keane, Pearse A, additional, Jones, Pete R, additional, Holland, Peter, additional, Nukella, Phanindra Babu, additional, Burgess, Philip I, additional, O'Dwyer, Pinar Aydin, additional, Piyasena, Prabhath, additional, Bastola, Pradeep, additional, Morjaria, Priya, additional, Nasimee, Qais, additional, Rambacal, Raizza A T, additional, Das, Rajdeep, additional, Khandekar, Rajiv B, additional, Azad, Rajvardhan, additional, Bashshur, Ramona, additional, Sousa, Raúl A R C, additional, Oenga, Rebecca, additional, Gurung, Reeta, additional, Geneau, Robert, additional, Jacobs, Robert J, additional, Finger, Robert P, additional, Guymer, Robyn H, additional, Sevciuc, Rodica, additional, Khanna, Rohit C, additional, George, Ronnie, additional, Graham, Ronnie, additional, Kawasaki, Ryo, additional, Ho, S May, additional, Mishra, Sailesh Kumar, additional, Buttan, Sandeep, additional, Block, Sandra S, additional, Talero, Sandra, additional, Yoon, Sangchul, additional, Joseph, Sanil, additional, Safi, Sare, additional, Dodson, Sarity, additional, Munoz, Sergio R, additional, Bakayoko, Seydou, additional, Mohammadi, Seyed Farzad, additional, Muez, Shabir Ahmad, additional, Pardhan, Shahina, additional, Hopkins, Shelley, additional, Sheu, Shwu-Jiuan, additional, Coulibaly, Sidi Mohamed, additional, Schellini, Silvana A, additional, Arunga, Simon, additional, Bush, Simon R, additional, Sivaprasad, Sobha, additional, Salomao, Solange R, additional, Marmamula, Srinivas, additional, Onwubiko, Stella N, additional, Misra, Stuti L, additional, Kuyyadiyil, Subeesh, additional, Kulkarni, Sucheta, additional, khanal, Sudarshan, additional, Yasmin, Sumrana, additional, Pavljasevic, Suzana Nikolic, additional, Gilbert, Suzanne S, additional, Braithwaite, Tasanee, additional, Ghidirimschi, Tatiana, additional, Ravilla, Thulasiraj, additional, Fricke, Timothy R, additional, Cogliati, Tiziana, additional, Kassa, Tsehaynesh, additional, Peto, Tunde, additional, Dibb, Ute, additional, Lansingh, Van C, additional, Hu, Victor H, additional, Sheffield, Victoria M, additional, Mathenge, Wanjiku, additional, Dean, William H, additional, Nolan, Winifred, additional, Hiratsuka, Yoshimune, additional, Mahsood, Yousaf Jamal, additional, and Sapkota, Yuddha, additional

Published
2022
Full Text
View/download PDF

30. Authors' reply

Author

Khaw, Peng Tee, Shah, Peter, and Elkington, Andrew R

Published
2004

35. Retinal asymmetry in multiple sclerosis

Author

Petzold, Axel, Chua, Sharon Y. L., Khawaja, Anthony P., Keane, Pearse A., Khaw, Peng T., Reisman, Charles, Dhillon, Baljean, Strouthidis, Nicholas G., Foster, Paul J., Patel, Praveen J., Atan, Denize, Aslam, Tariq, Barman, Sarah A., Barrett, Jenny H., Bishop, Paul, Bunce, Catey, Carare, Roxana O., Chakravarthy, Usha, Chan, Michelle, Crabb, David P., Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew D., Egan, Cathy, Ennis, Sarah, Fruttiger, Marcus, Gallacher, John E. J., Garway-Heath, David F., Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A., Hammond, Chris J., Hardcastle, Alison, Harding, Simon P., Hogg, Ruth E., Hysi, Pirro, Khaw, Sir Peng T., Lascaratos, Gerassimos, Lotery, Andrew J., MacGillivray, Tom, MacKie, Sarah, McGaughey, Michelle, McGuinness, Bernadette, McKay, Gareth J., McKibbin, Martin, Moore, Tony, Morgan, James E., Muthy, Zaynah A., O'Sullivan, Eoin, Owen, Chris G., Patel, Praveen, Paterson, Euan, Peto, Tunde, Rahi, Jugnoo S., Rudnikca, Alicja R., Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vitart, Veronique, Vernon, Stephen A., Viswanathan, Ananth C., Williams, Cathy, Williams, Katie, Woodside, Jayne V., Yates, Max M., Zheng, Yalin, Consortium, UK Biobank Eye and Vision, Gallacher, JE, Neurology, Ophthalmology, APH - Mental Health, APH - Methodology, and Amsterdam Neuroscience - Neuroinfection & -inflammation

Subjects
Male, genetic structures, Youden's J statistic, Optic neuritis, Imaging, chemistry.chemical_compound, 0302 clinical medicine, medicine.diagnostic_test, AcademicSubjects/SCI01870, imaging, Middle Aged, Biobank, Female, demyelination, Demyelination, Tomography, Optical Coherence, medicine.medical_specialty, Multiple Sclerosis, Clinical Neurology, Sensitivity and Specificity, Retina, Multiple sclerosis, 03 medical and health sciences, Optical coherence tomography, SDG 3 - Good Health and Well-being, Ophthalmology, medicine, Humans, optic neuritis, Research ethics, Community level, Neuromyelitis optica, Receiver operating characteristic, business.industry, biomarkers, Retinal, Original Articles, medicine.disease, Confidence interval, eye diseases, chemistry, North west, 030221 ophthalmology & optometry, Optometry, AcademicSubjects/MED00310, RE, Neurology (clinical), sense organs, business, 030217 neurology & neurosurgery, Biomarkers, RC
Abstract

In a large community-based study, Petzold et al. show that optical coherence tomography measures of retinal asymmetry have high diagnostic sensitivity for multiple sclerosis, particularly in younger individuals without relevant comorbidities. The technique should be considered in future revisions of diagnostic criteria., The diagnosis of multiple sclerosis is based on a combination of clinical and paraclinical tests. The potential contribution of retinal optical coherence tomography (OCT) has been recognized. We tested the feasibility of OCT measures of retinal asymmetry as a diagnostic test for multiple sclerosis at the community level. In this community-based study of 72 120 subjects, we examined the diagnostic potential of the inter-eye difference of inner retinal OCT data for multiple sclerosis using the UK Biobank data collected at 22 sites between 2007 and 2010. OCT reporting and quality control guidelines were followed. The inter-eye percentage difference (IEPD) and inter-eye absolute difference (IEAD) were calculated for the macular retinal nerve fibre layer (RNFL), ganglion cell inner plexiform layer (GCIPL) complex and ganglion cell complex. Area under the receiver operating characteristic curve (AUROC) comparisons were followed by univariate and multivariable comparisons accounting for a large range of diseases and co-morbidities. Cut-off levels were optimized by ROC and the Youden index. The prevalence of multiple sclerosis was 0.0023 [95% confidence interval (CI) 0.00229–0.00231]. Overall the discriminatory power of diagnosing multiple sclerosis with the IEPD AUROC curve (0.71, 95% CI 0.67–0.76) and IEAD (0.71, 95% CI 0.67–0.75) for the macular GCIPL complex were significantly higher if compared to the macular ganglion cell complex IEPD AUROC curve (0.64, 95% CI 0.59–0.69, P = 0.0017); IEAD AUROC curve (0.63, 95% CI 0.58–0.68, P 0.14) with narrow confidence intervals. In conclusion, the OCT macular GCIPL complex IEPD and IEAD may be considered as supportive measurements for multiple sclerosis diagnostic criteria in a young patient without relevant co-morbidity. The metric does not allow separation of multiple sclerosis from neuromyelitis optica. Retinal OCT imaging is accurate, rapid, non-invasive, widely available and may therefore help to reduce need for invasive and more costly procedures. To be viable, higher sensitivity and specificity levels are needed.

Published
2021
Full Text
View/download PDF

36. Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images

Author

Currant, Hannah, Hysi, Pirro, Fitzgerald, Tomas W., Gharahkhani, Puya, Bonnemaijer, Pieter W.M., Senabouth, Anne, Hewitt, Alex W., Atan, Denize, Aung, Tin, Charng, Jason, Choquet, Hélène, Craig, Jamie, Khaw, Peng T., Klaver, Caroline C.W., Kubo, Michiaki, Ong, Jue Sheng, Pasquale, Louis R., Reisman, Charles A., Daniszewski, Maciej, Powell, Joseph E., Pébay, Alice, Simcoe, Mark J., Thiadens, Alberta A.H.J., van Duijn, Cornelia M., Yazar, Seyhan, Jorgenson, Eric, MacGregor, Stuart, Hammond, Chris J., Mackey, David A., Wiggs, Janey L., Foster, Paul J., Patel, Praveen J., Birney, Ewan, Khawaja, Anthony P., Currant, Hannah, Hysi, Pirro, Fitzgerald, Tomas W., Gharahkhani, Puya, Bonnemaijer, Pieter W.M., Senabouth, Anne, Hewitt, Alex W., Atan, Denize, Aung, Tin, Charng, Jason, Choquet, Hélène, Craig, Jamie, Khaw, Peng T., Klaver, Caroline C.W., Kubo, Michiaki, Ong, Jue Sheng, Pasquale, Louis R., Reisman, Charles A., Daniszewski, Maciej, Powell, Joseph E., Pébay, Alice, Simcoe, Mark J., Thiadens, Alberta A.H.J., van Duijn, Cornelia M., Yazar, Seyhan, Jorgenson, Eric, MacGregor, Stuart, Hammond, Chris J., Mackey, David A., Wiggs, Janey L., Foster, Paul J., Patel, Praveen J., Birney, Ewan, and Khawaja, Anthony P.

Abstract

Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma. We present the first large-scale genome-wide association study of inner retinal morphology using phenotypes derived from OCT images of 31,434 UK Biobank participants. We identify 46 loci associated with thickness of the retinal nerve fibre layer or ganglion cell inner plexiform layer. Only one of these loci has been associated with glaucoma, and despite its clear role as a biomarker for the disease, Mendelian randomisation does not support inner retinal thickness being on the same genetic causal pathway as glaucoma. We extracted overall retinal thickness at the fovea, representative of foveal hypoplasia, with which three of the 46 SNPs were associated. We additionally associate these three loci with visual acuity. In contrast to the Mendelian causes of severe foveal hypoplasia, our results suggest a spectrum of foveal hypoplasia, in part genetically determined, with consequences on visual function.

Published
2021

38. Ambient Air Pollution Associations with Retinal Morphology in the UK Biobank

Author

Chua, Sharon Y.L., Khawaja, Anthony P., Dick, Andrew D., Morgan, James, Dhillon, Baljean, Lotery, Andrew J., Strouthidis, Nicholas G., Reisman, Charles, Peto, Tunde, Khaw, Peng T., Foster, Paul J., Patel, Praveen J., Littlejohns, Thomas, Allen, Naomi, Beli, Eleni, Atan, Denize, Aslam, Tariq, Barman, Sarah A., Barrett, Jenny H., Bishop, Paul, Bunce, Catey, Carare, Roxana O., Chakravarthy, Usha, Chan, Michelle, Crabb, David P., Day, Alexander, Desai, Parul, Dhillon, Bal, Egan, Cathy, Ennis, Sarah, Fruttiger, Marcus, Gallacher, John E.J., Garway-Heath, David F., Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A., Hammond, Chris J., Hardcastle, Alison, Harding, Simon P., Hogg, Ruth E., Hysi, Pirro, Keane, Pearse A., Lascaratos, Gerassimos, Macgillivray, Tom, Mackie, Sarah, McGaughey, Michelle, McGuinness, Bernadette, McKay, Gareth J., McKibbin, Martin, Moore, Tony, Morgan, James E., Muthy, Zaynah A., O’Sullivan, Eoin, Owen, Chris G., Paterson, Euan, Petzold, Axel, Rahi, Jugnoo S., Rudnikca, Alicja R., Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vitart, Veronique, Vernon, Stephen A., Viswanathan, Ananth C., Williams, Cathy, Williams, Katie, Woodside, Jayne V., Yates, Max M., and Zheng, Yalin

Subjects
Adult, Male, Retinal Ganglion Cells, medicine.medical_specialty, Retinal layers, air pollution, Air pollution, Nerve fiber layer, Glaucoma, Outer plexiform layer, Retinal Pigment Epithelium, Absorbance, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nerve Fibers, Retinal Diseases, Ophthalmology, Surveys and Questionnaires, medicine, Humans, Outer nuclear layer, Aged, Biological Specimen Banks, Chemistry, Clinical and Epidemiologic Research, Retinal, retinal layers, Middle Aged, medicine.disease, GF, SDG 11 - Sustainable Cities and Communities, United Kingdom, medicine.anatomical_structure, Cross-Sectional Studies, OCT, Inner nuclear layer, 030221 ophthalmology & optometry, Female, Nitrogen Oxides, Particulate Matter, RE, sense organs, Layer (electronics), 030217 neurology & neurosurgery, Tomography, Optical Coherence, Photoreceptor Cells, Vertebrate
Abstract

PURPOSE. Because air pollution has been linked to glaucoma and AMD, we characterized the relationship between pollution and retinal structure. METHODS. We examined data from 51,710 UK Biobank participants aged 40 to 69 years old. Ambient air pollution measures included particulates and nitrogen oxides. SD-OCT imaging measured seven retinal layers: retinal nerve fiber layer, ganglion cell–inner plexiform layer, inner nuclear layer, outer plexiform layer + outer nuclear layer, photoreceptor inner segments, photoreceptor outer segments, and RPE. Multivariable regression was used to evaluate associations between pollutants (per interquartile range increase) and retinal thickness, adjusting for age, sex, race, Townsend deprivation index, body mass index, smoking status, and refractive error. RESULTS. Participants exposed to greater particulate matter with an aerodynamic diameter of CONCLUSIONS. Greater exposure to PM2.5, PM2.5 absorbance, and nitrogen oxides were all associated with apparently adverse retinal structural features.

Published
2020
Full Text
View/download PDF

41. Estimating the global cost of vision impairment and its major causes: protocol for a systematic review

Author

Marques, Ana Patricia, primary, Ramke, Jacqueline, additional, Cairns, John, additional, Butt, Thomas, additional, Zhang, Justine H, additional, Faal, Hannah B, additional, Taylor, Hugh, additional, Jones, Iain, additional, Congdon, Nathan, additional, Bastawrous, Andrew, additional, Braithwaite, Tasanee, additional, Jovic, Marty, additional, Resnikoff, Serge, additional, Nandakumar, Allyala, additional, Khaw, Peng Tee, additional, Bourne, Rupert R A, additional, Gordon, Iris, additional, Frick, Kevin, additional, and Burton, Matthew J, additional

Published
2020
Full Text
View/download PDF

42. Mutations in SPATA13/ASEF2 cause primary angle closure glaucoma

Author

Waseem, Naushin H., primary, Low, Sancy, additional, Shah, Amna Z., additional, Avisetti, Deepa, additional, Ostergaard, Pia, additional, Simpson, Michael, additional, Niemiec, Katarzyna A., additional, Martin-Martin, Belen, additional, Aldehlawi, Hebah, additional, Usman, Saima, additional, Lee, Pak Sang, additional, Khawaja, Anthony P., additional, Ruddle, Jonathan B., additional, Shah, Ameet, additional, Sackey, Ege, additional, Day, Alexander, additional, Jiang, Yuzhen, additional, Swinfield, Geoff, additional, Viswanathan, Ananth, additional, Alfano, Giovanna, additional, Chakarova, Christina, additional, Cordell, Heather J., additional, Garway-Heath, David F., additional, Khaw, Peng T., additional, Bhattacharya, Shomi S., additional, Waseem, Ahmad, additional, and Foster, Paul J., additional

Published
2020
Full Text
View/download PDF

46. Multi-trait genome-wide association study identifies new loci associated with optic disc parameters

Author

Bonnemaijer, Pieter WM, van Leeuwen, Elisabeth M, Iglesias, Adriana I, Gharahkhani, Puya, Vitart, Veronique, Khawaja, Anthony P, Simcoe, Mark, Hoehn, Rene, Cree, Angela J, Igo, Rob P, Burdon, Kathryn P, Craig, Jamie E, Hewitt, Alex W, Jonas, Jost, Khor, Chiea-Cheun, Pasutto, Francesca, Mackey, David A, Mitchell, Paul, Mishra, Aniket, Pang, Calvin, Pasquale, Louis R, Springelkamp, Henriette, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Viswanathan, Ananth C, Wojciechowski, Robert, Wong, Tien, Young, Terrri L, Zeller, Tanja, Atan, Denize, Aslam, Tariq, Barman, Sarah A, Barrett, Jenny H, Bishop, Paul, Blows, Peter, Bunce, Catey, Carare, Roxana O, Chakravarthy, Usha, Chan, Michelle, Chua, Sharon YL, Crabb, David P, Cumberland, Philippa M, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew D, Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John EJ, Garway, David F, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A, Hardcastle, Alison, Harding, Simon P, Hogg, Ruth E, Keane, Pearse A, Khaw, Peng T, Lascaratos, Gerassimos, Macgillivray, Tom, Mackie, Sarah, Martin, Keith, McGaughey, Michelle, McGuinness, Bernadette, Mckay, Gareth J, McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James E, Muthy, Zaynah A, O'Sullivan, Eoin, Owen, Chris G, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Rahi, Jugnoo S, Rudnikca, Alicja R, Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vernon, Stephen A, Williams, Cathy, Williams, Katie, Woodside, Jayne V, Yates, Max M, Yip, Jennifer, Zheng, Yalin, Allingham, Rand, Budenz, Don, Bailey, Jessica Cooke, Fingert, John, Gaasterland, Douglas, Gaasterland, Teresa, Haines, Jonathan L, Hark, Lisa, Hauser, Michael, Kang, Jae Hee, Kraft, Peter, Lee, Richard, Lichter, Paul, Liu, Yutao, Moroi, Syoko, Pericak, Margaret, Realini, Anthony, Rhee, Doug, Richards, Julia R, Ritch, Robert, Scott, William K, Singh, Kuldev, Sit, Arthur, Vollrath, Douglas, Weinreb, Robert, Wollstein, Gadi, Wilmer, Don Zack, Gerhold-Ay, Aslihan, Nickels, Stefan, Wilson, James F, Hayward, Caroline, Boutin, Thibaud S, Polasek, Ozren, Aung, Tin, Khor, Chiea Chuen, Amin, Najaf, Lotery, Andrew J, Wiggs, Janey L, Cheng, Ching-Yu, Hysi, Pirro G, Hammond, Christopher J, Thiadens, Alberta AHJ, MacGregor, Stuart, Klaver, Caroline CW, van Duijn, Cornelia M, Consortium, Int Glaucoma Genetics, Consortium, Uk Biobank Eye Vision, Consortium, NEIGHBORHOOD, Epidemiology, Ophthalmology, Clinical Genetics, Bonnemaijer, Pieter WM [0000-0001-5154-6765], Iglesias, Adriana I [0000-0001-5532-764X], Gharahkhani, Puya [0000-0002-4203-5952], Vitart, Veronique [0000-0002-4991-3797], Khawaja, Anthony P [0000-0001-6802-8585], Simcoe, Mark [0000-0003-2432-0810], Nickels, Stefan [0000-0003-0415-2354], Wilson, James F [0000-0001-5751-9178], Hayward, Caroline [0000-0002-9405-9550], Boutin, Thibaud S [0000-0003-4754-1675], Khor, Chiea Chuen [0000-0002-1128-4729], Lotery, Andrew J [0000-0001-5541-4305], Wiggs, Janey L [0000-0003-1890-3278], Cheng, Ching-Yu [0000-0003-0655-885X], Hysi, Pirro G [0000-0001-5752-2510], Hammond, Christopher J [0000-0002-3227-2620], MacGregor, Stuart [0000-0001-6731-8142], Klaver, Caroline CW [0000-0002-2355-5258], and Apollo - University of Cambridge Repository

Subjects
genetic structures, Optic disk, Medicine (miscellaneous), Genome-wide association study, Neurodegenerative, Genome-wide association studies, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], 0302 clinical medicine, Optic Nerve Diseases, 2.1 Biological and endogenous factors, Aetiology, 610 Medicine & health, lcsh:QH301-705.5, 0303 health sciences, Agricultural and Biological Sciences(all), Single Nucleotide, medicine.anatomical_structure, NEIGHBORHOOD consortium, General Agricultural and Biological Sciences, Optic disc, Signal Transduction, Optic Disk, Quantitative Trait Loci, International Glaucoma Genetics Consortium, Quantitative trait locus, Biology, Genetic correlation, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, UK Biobank Eye and Vision Consortium, 03 medical and health sciences, Quantitative Trait, Quantitative Trait, Heritable, medicine, Genetics, Humans, Genetic Predisposition to Disease, 1000 Genomes Project, Polymorphism, Heritable, Eye Disease and Disorders of Vision, Genetic Association Studies, 030304 developmental biology, Genetic association, CENTRAL CORNEAL THICKNESS, METAANALYSIS, GLAUCOMA, EXPRESSION, HERITABILITY, PREVALENCE, STATISTICS, PANEL, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, Haplotype, Human Genome, Computational Biology, Glaucoma, Molecular Sequence Annotation, eye diseases, lcsh:Biology (General), Evolutionary biology, Case-Control Studies, RE, sense organs, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

A new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the genetic correlation of traits, which reflects the number of pleiotropic loci, i.e. genetic loci influencing multiple traits. Here, we applied new meta-analyses of optic nerve head (ONH) related traits implicated in primary open-angle glaucoma (POAG); intraocular pressure and central corneal thickness using Haplotype reference consortium imputations. We performed a multi-trait analysis of ONH parameters cup area, disc area and vertical cup-disc ratio. We uncover new variants; rs11158547 in PPP1R36-PLEKHG3 and rs1028727 near SERPINE3 at genome-wide significance that replicate in independent Asian cohorts imputed to 1000 Genomes. At this point, validation of these variants in POAG cohorts is hampered by the high degree of heterogeneity. Our results show that multi-trait analysis is a valid approach to identify novel pleiotropic variants for ONH., The International Glaucoma Genetics Consortium reports a genome-wide association study meta-analysis of optic disc parameters relevant to primary open-angle glaucoma. They identify two novel variants in PPP1R36-PLEKHG3 and SERPINE3 by multi-trait analysis in European-ancestry cohorts that were replicated in independent Asian cohorts.

Published
2019
Full Text
View/download PDF

47. The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM2.5) and Glaucoma in a Large Community Cohort

Author

Chua, Sharon YL, Khawaja, Anthony P, Morgan, James, Strouthidis, Nicholas, Reisman, Charles, Dick, Andrew D, Khaw, Peng T, Patel, Praveen J, Foster, Paul J, Atan, Denize, Aslam, Tariq, Barman, Sarah A, Barrett, Jenny H, Bishop, Paul, Bunce, Catey, Carare, Roxana O, Chakravarthy, Usha, Chan, Michelle, Crabb, David P, Day, Alexander, Desai, Parul, Dhillon, Bal, Egan, Cathy, Ennis, Sarah, Fruttiger, Marcus, Gallacher, John EJ, Garway-Heath, David F, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A, Hammond, Chris J, Hardcastle, Alison, Harding, Simon P, Hogg, Ruth E, Hysi, Pirro, Keane, Pearse A, Lascaratos, Gerassimos, Lotery, Andrew J, Macgillivray, Tom, Mackie, Sarah, McGaughey, Michelle, McGuinness, Bernadette, McKay, Gareth J, McKibbin, Martin, Moore, Tony, Muthy, Zaynah A, O'Sullivan, Eoin, Owen, Chris G, Paterson, Euan, Peto, Tunde, Petzold, Axel, Rahi, Jugnoo S, Rudnikca, Alicja R, Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vitart, Veronique, Vernon, Stephen A, Viswanathan, Ananth C, Williams, Cathy, Williams, Katie, Woodside, Jayne V, Yates, Max M, Zheng, Yalin, and Consortium, UK Biobank Eye Vision

Subjects
Adult, Male, Retinal Ganglion Cells, Intraocular pressure, medicine.medical_specialty, optical coherence, genetic structures, Population, Glaucoma, tomography, Tonometry, Ocular, Nerve Fibers, Interquartile range, Air Pollution, Surveys and Questionnaires, Ophthalmology, Humans, Medicine, education, Intraocular Pressure, Aged, Air Pollutants, education.field_of_study, business.industry, Odds ratio, Diabetic retinopathy, Middle Aged, medicine.disease, Confidence interval, eye diseases, glaucoma, fine particulate matter, Cohort, GCIPL, Female, Particulate Matter, Self Report, sense organs, Visual Fields, business, Tomography, Optical Coherence, intraocular pressure
Abstract

PURPOSE: Glaucoma is more common in urban populations than in others. Ninety percent of the world's population are exposed to air pollution above World Health Organization (WHO) recommended limits. Few studies have examined the association between air pollution and glaucoma. METHODS: Questionnaire data, ophthalmic measures, and ambient residential area air quality data for 111,370 UK Biobank participants were analyzed. Particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5) was selected as the air quality exposure of interest. Eye measures included self-reported glaucoma, intraocular pressure (IOP), and average thickness of macular ganglion cell-inner plexiform layer (GCIPL) across nine Early Treatment Diabetic Retinopathy Study (ETDRS) retinal subfields as obtained from spectral-domain optical coherence tomography. We examined the associations of PM2.5 concentration with self-reported glaucoma, IOP, and GCIPL. RESULTS: Participants resident in areas with higher PM2.5 concentration were more likely to report a diagnosis of glaucoma (odds ratio = 1.06, 95% confidence interval [CI] = 1.01-1.12, per interquartile range [IQR] increase P = 0.02). Higher PM2.5 concentration was also associated with thinner GCIPL (β = -0.56 μm, 95% CI = -0.63 to -0.49, per IQR increase, P = 1.2 × 10-53). A dose-response relationship was observed between higher levels of PM2.5 and thinner GCIPL (P < 0.001). There was no clinically relevant relationship between PM2.5 concentration and IOP. CONCLUSIONS: Greater exposure to PM2.5 is associated with both self-reported glaucoma and adverse structural characteristics of the disease. The absence of an association between PM2.5 and IOP suggests the relationship may occur through a non-pressure-dependent mechanism, possibly neurotoxic and/or vascular effects.

Published
2019
Full Text
View/download PDF

48. Cohort profile: design and methods in the eye and vision consortium of UK Biobank

Author

Chua, Sharon Yu Lin, Thomas, Dhanes, Allen, Naomi, Lotery, Andrew, Desai, Parul, Patel, Praveen, Muthy, Zaynah, Sudlow, Cathie, Peto, Tunde, Khaw, Peng Tee, Foster, Paul J, and UK Biobank Eye & Vision Consortium

Subjects
Adult, Male, Eye Diseases, genetic structures, Epidemiology, Visual Acuity, Ethnicity, Humans, Macula Lutea, Prospective Studies, medical retina, Intraocular Pressure, Aged, Biological Specimen Banks, Cohort Profile, Organ Size, Middle Aged, medical ophthalmology, United Kingdom, eye diseases, Female, sense organs, Tomography, Optical Coherence, dementia
Abstract

PURPOSE:To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. PARTICIPANTS:UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. FINDINGS TO DATE:A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. FUTURE PLANS:UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2-3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.

Published
2019
Full Text
View/download PDF

49. Development of Targeted siRNA Nanocomplexes to Prevent Fibrosis in Experimental Glaucoma Filtration Surgery

Author

Fernando, Owen, Tagalakis, Aristides D., Awwad, Sahar, Brocchini, Steve, Khaw, Peng T., Hart, Stephen L., and Yu-Wai-Man, Cynthia

Subjects
glaucoma, targeting peptide, nanoparticle, siRNA, fibrosis
Abstract

RNAi induced by double-stranded small interfering RNA (siRNA) molecules has attracted great attention as a naturally occurring approach to silence gene expression with high specificity. The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway is a master regulator of cytoskeletal gene expression and, thus, represents a promising target to prevent fibrosis. A major hurdle to implementing siRNA therapies is the method of delivery, and we have, thus, optimized lipid-peptide-siRNA (LPR) nanoparticles containing MRTF-B siRNAs as a targeted approach to prevent conjunctival fibrosis. We tested 15 LPR nanoparticle formulations with different lipid compositions, surface charges, and targeting or non-targeting peptides in human conjunctival fibroblasts. In vitro, the LPR formulation of the DOTMA/DOPE lipid with the targeting peptide Y (LYR) was the most efficient in MRTF-B gene silencing and non-cytotoxic compared to the non-targeting formulation. In vivo, subconjunctival administration of LYR nanoparticles containing MRTF-B siRNAs doubled bleb survival in a pre-clinical rabbit model of glaucoma filtration surgery. Furthermore, MRTF-B LYR nanoparticles reduced the MRTF-B mRNA by 29.6% in rabbit conjunctival tissues, which led to significantly decreased conjunctival scarring with no adverse side effects. LYR-mediated delivery of siRNA shows promising results to increase bleb survival and to prevent conjunctival fibrosis after glaucoma filtration surgery. RNAi induced by double-stranded, small interfering RNA (siRNA) is a naturally occurring approach to silence gene expression with high specificity. Yu-Wai-Man and colleagues show that lipid-peptide-siRNA (LPR) nanoparticles significantly increase bleb survival and prevent conjunctival fibrosis in a pre-clinical model of glaucoma filtration surgery.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results