34 results on '"Keske, Murat"'
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2. Prone versus Barts “flank-free” modified supine percutaneous nephrolithotomy: a match-pair analysis
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MİÇOOĞULLARI, Uygar, primary, KAMACI, Davut, additional, YILDIZHAN, Mehmet, additional, UMUT KILIÇ, Furkan, additional, ÇETİN, Taha, additional, ÇAKICI, Özer Ural, additional, KESKE, Murat, additional, YİĞİT YALÇIN, Mehmet, additional, and ARDIÇOĞLU, Arslan, additional
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- 2021
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3. Robot assisted radical prostatectomy in elderly patients older than 70 years old: Operative, oncologic and functional outcomes
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Asil, Erem, primary, Yıldızhan, Mehmet, additional, Koç, Erdem, additional, Keske, Murat, additional, Gök, Bahri, additional, Canda, Abdullah Erdem, additional, Atmaca, Ali Fuat, additional, and Balbay, M. Derya, additional
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- 2021
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4. Transrektal Ultrason Kılavuzluğunda Prostat Biyopsisi Yapılan Hastalarda Vücut Kitle İndeksine Göre Kanser Saptama Oranlarının Karşılaştırılması
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SÖNMEZ, Gökhan, KESKE, Murat, TOPALOĞLU, Ulaş Serkan, and DEMİR, Fatih
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prostat kanseri,PSA,vücut kitle indeksi ,Health Care Sciences and Services ,Sağlık Bilimleri ve Hizmetleri - Abstract
Amaç:Bu çalışmada prostat kanseri şüphesi nedeniyletransrektal ultrasonografi kılavuzluğunda prostat iğne biyopsisi uygulananhastaların, vücut kitle indekslerine göre kanser tespit edilme oranlarınınkarşılaştırılması amaçlanmıştır. Gereçve Yöntem: Retrospektif özellikteki bu çalışmaya serumPSA değeri 20 ng/ml altında olan ve prostat kanseri şüphesi nedeniyle TRUS-Buygulanan hastalar çalışmaya dahil edilmiştir. Hastaların yaş, boy, kilo, vücutkitle indeksi gibi demografik verilerinin yanı sıra serum PSA düzeyleri,prostat hacimleri, kanser tespit edilme oranları gibi klinik verileriincelenmiştir.Bulgular: Hastaların 78 tanesi grup-1 (VKİ
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- 2019
5. Nadir Bir Olgu: Eş Zamanlı Bilateral Brusella Orşiti
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Keske, Murat, Karadağ, Mert Ali, Sağlık, Lütif, Biçer, Hüseyin, Demir, Fatih, Kaya, Reşat, Yeşil, Yüksel, and SÖNMEZ, Gökhan
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- 2018
6. Radikal Prostatektomi Sırasında Gelişen ve Geç Dönemde Mesane Boynu Ekstravazsyonunu Taklit Eden İyatrojenik Üreter Yaralanması
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Sağlık, Lütif, SÖNMEZ, Gökhan, Demir, Fatih, Biçer, Hüseyin, Karadağ, Mert Ali, Keske, Murat, Yeşil, Yüksel, and Öztekin, Ünal
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- 2018
7. Testis-sparing surgery: experience in 13 patients with oncological and functional outcomes
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Canda, Abdullah Erdem (ORCID 0000-0002-5196-653X & YÖK ID 116202); Balbay, Mevlana Derya (ORCID 0000-0001-9706-1587 & YÖK ID 153320), Keske, Murat; Atmaca, Ali Fuat; Çakıcı, Özer Ural; Arslan, Muhammed Ersagun; Kamacı, Davut, School of Medicine, Department of Urology, Canda, Abdullah Erdem (ORCID 0000-0002-5196-653X & YÖK ID 116202); Balbay, Mevlana Derya (ORCID 0000-0001-9706-1587 & YÖK ID 153320), Keske, Murat; Atmaca, Ali Fuat; Çakıcı, Özer Ural; Arslan, Muhammed Ersagun; Kamacı, Davut, School of Medicine, and Department of Urology
- Abstract
Introduction: we present oncological and functional outcomes of patients who underwent testis-sparing surgery (TSS). Methods: overall, 13 patients were included. Mean patient age was 29.9 +/- 12.5 years. In five patients, TSS was performed for sequential bilateral testicular tumours. One patient underwent concurrent left radical orchiectomy and right TSS. In eight patients with normal contralateral testis, seven underwent left and one underwent right TSS. Results: mean pathological tumour size was 14.6 +/- 12.5 mm. lntraoperative frozen section evaluation of the mass was performed in eight patients that revealed benign lesions. No intraoperative tumour bed biopsies were taken in this patient group. Regarding the remaining five patients, intraoperative tumour bed biopsies were taken and testicular intraepithelial neoplasia (TIN) was reported in two (40%) patients; no local testicular radiotherapy was given postoperatively. Tumour pathology was malignant in all but one lesion, including Leydig cell tumour (n=1), seminoma(n=2), embryonal carcinoma (n=1), and adenomatoid tumour (n=1). During 47.2 +/- 22.5 months of followup, local recurrence was detected in one patient who underwent radical orchiectomy. No additional local recurrence or systemic metastasis was identified in other patients with malignant lesions. For patients with malignant tumours, of the three patients with a normal preoperative testosterone levels, testosterone level was normal in one patient (with no erectile dysfunction [ED]) and was decreased in two patients (with ED) following TSS. No ED was reported in the nine patients with benign lesions. Conclusions: in carefully selected cases, TSS appears to be a safe, feasible procedure with adequate cancer control that could preserve sexual function., NA
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- 2019
8. Robotic radical prostatectomy in 93 cases: outcomes of the first ERUS robotic urology curriculum trained surgeon in Turkey
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Canda, Abdullah Erdem (ORCID 0000-0002-5196-653X & YÖK ID 116202), Bedir, Fevzi; Keske, Murat; Demirdöğen, Şaban Oğuz; Kocatürk, Hüseyin; Koç, Erdem; Atmaca, Ali Fuat, School of Medicine, Department of Urology, Canda, Abdullah Erdem (ORCID 0000-0002-5196-653X & YÖK ID 116202), Bedir, Fevzi; Keske, Murat; Demirdöğen, Şaban Oğuz; Kocatürk, Hüseyin; Koç, Erdem; Atmaca, Ali Fuat, School of Medicine, and Department of Urology
- Abstract
Objective: this study presents the surgical, oncological, and functional outcomes of the first 93 robotic radical prostatectomy (RARP) procedures performed in Erzurum, Turkey. These procedures were performed by a single surgeon who had completed the European Association of Urology Robotic Urology Section (ERUS) RA RP curriculum in an ERUS-certified training center in Ankara. Material and methods: The study present the results of 93 RARP procedures performed by a single surgeon. The surgeon performing the operations completed an ERUS training program structured for RARP by two robotic surgeons holding ERUS training certificates in an ERUS-approved academic robotic surgery training center in Ankara.The RARP cases performed by the surgeon after completion of the training between April 2016 and August 2018 were retrospectively evaluated. Results: the mean patient age was 63.62 +/- 7.04 years, and the mean preoperative serum prostate-specific antigen level was 8.34 +/- 496 ng/mL. Preoperatively, 82 and 4 patients had prostate biopsy Gleason scores of 3+3 and 4+3, respectively. Bilateral neurovascular bundle (NVB) sparing, unilateral NVB-sparing, and non-NVB-sparing surgery were performed in 21, 13, and 59 cases, respectively. The mean prostate weight was 85.34 +/- 47.57 g Posterior rhabdosphincter reconstruction was performed in 60 (64.5%) cases. Mean console time, intraoperative blood loss, duration of hospital stay, and urethral catheter removal time were 170.49 +/- 36.50 min, 100.70 +/- 34.08 cc, 6.84 +/- 2.28 days, and 7.40 +/- 3.11 days, respectively. During the perioperative period (0-30 days), five minor (prolonged drain output, n=3; rectocele, n=1; gout arthritis, n=1) and six major (inguinal hernia, n=1; incisional hernia, n=2; anastomotic urinary leakage, n=2; myocardial infarction, n=1) complications were identified. No complication was detected during postoperative days 31-90. Postoperative pathological stages included pT'2a, pT2b, and pT2c disease in 77 (82., NA
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- 2019
9. Nadir Görülen Bir Tümör: Peritestiküler Leiomyosarkom
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Kaya, Reşat, SÖNMEZ, Gökhan, Demir, Fatih, Karadağ, Mert Ali, Keske, Murat, Yeşil, Yüksel, Biçer, Hüseyin, and Sağlık, Lütif
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- 2018
10. Korumak ya da korumamak? Robotik radikal prostatektomide mesane boynu
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Keske, Murat, primary and Canda, Abdullah Erdem, additional
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- 2019
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11. Transüretral Prostat Rezeksiyonu Geçirmiş Olmak Robotik Radikal Prostatektomi Sonuçlarını Nasıl Etkiler?
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Keske, Murat, primary, Canda, Abdullah Erdem, additional, Atmaca, Ali Fuat, additional, Hamidi, Nurullah, additional, and Balbay, Mevlana Derya, additional
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- 2019
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12. Diagnosis and Conservative Management of Ureteral Orifice Injury During Robotic Prostatectomy for a Large Prostate with a Prominent Median Lobe
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Bedir, Fevzi, primary, Keske, Murat, additional, Demirdogen, Saban Oguz, additional, Kocaturk, Huseyin, additional, Atmaca, Ali Fuat, additional, and Canda, Abdullah Erdem, additional
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- 2019
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13. 70 Yaş Üstü Hastalarda Robot Yardımlı Radikal Prostatektomi: Operatif, Onkolojik, ve Fonksiyonel Sonuçlar.
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Asil, Erem, Yıldızhan, Mehmet, Koç, Erdem, Keske, Murat, Gök, Bahri, Canda, Abdullah Erdem, Atmaca, Ali Fuat, and Balbay, M. Derya
- Abstract
Copyright of Van Tip Dergisi is the property of Yuzuncu Yil University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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14. Testis-sparing surgery: Experience in 13 patients with oncological and functional outcomes
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Keske, Murat, primary, Canda, Abdullah Erdem, additional, Atmaca, Ali Fuat, additional, Cakici, Ozer Ural, additional, Arslan, Muhammed Ersagun, additional, Kamaci, Davut, additional, and Balbay, Mevlana Derya, additional
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- 2018
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15. A Large Posteriorly Located Prostatic Mass Lesion Challenging the Robotic Surgeon: Prostate Leiomyoma
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Keske, Murat, primary, Canda, Abdullah Erdem, additional, Atmaca, Ali Fuat, additional, Bedir, Fevzi, additional, Gecit, Ilhan, additional, Ardicoglu, Arslan, additional, Aydogdu, Ozge Basaran, additional, Agackiran, Yetkin, additional, and Ocal, Berrak Gumuskaya, additional
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- 2017
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16. Is testis-sparing surgery safe in small testicular masses? Results of a multicentre study
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Keske, Murat, primary, Canda, Abdullah Erdem, additional, Yalcin, Serdar, additional, Kilicarslan, Aydan, additional, Kibar, Yusuf, additional, Tuygun, Can, additional, Onder, Evrim, additional, Atmaca, Ali Fuat, additional, Yildirim, Asif, additional, Ozkanli, Sidika Seyma, additional, Kandemir, Olcay, additional, Kargi, Taner, additional, Sar, Mehmet, additional, Tugcu, Volkan, additional, Resorlu, Berkan, additional, Aslan, Yilmaz, additional, Sarikaya, Selcuk, additional, Boylu, Ugur, additional, Cicek, Ali Fuat, additional, Basar, Halil, additional, Tuncel, Altug, additional, and Balbay, Mevlana Derya, additional
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- 2017
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17. Training Modalities in Robotic Prostate Cancer Surgery
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CANDA, Abdullah, KESKE, Murat, and ARSLAN, Muhammed
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body regions ,surgical procedures, operative ,education ,technology, industry, and agriculture ,Eğitim yöntemleri,robotik cerrahi,prostat kanseri cerrahisi ,Training modalities,robotic surgery,prostate cancer surgery ,human activities - Abstract
Robotic surgery is increasingly being performed worldwide in the surgical treatments of various diseases. Radical prostatectomy provides long-term cancer control in patients with localized prostate cancer. Robotic radical prostatectomy (RARP) has increasingly become a preferred treatment of choice both by patients and urologists since its introduction in 2001. The training of this surgical approach is a very important subject. This paper was prepared following reviewing the published literature on training on RARP, an internet bases search related with robotic prostate cancer surgery training and reviewing the training programs of the centers who offer training in robotic urology. In the present paper, we summarized the training modalities in RARP including; I. Video based learning: watching edited and non-edited surgical videos, II. Attending courses, symposiums and meetings related with robotic surgery, III. Watching live robotic surgical cases in the operating room, IV. Training with simulators, V. Training with the surgical surgical robot on training materials, VI. Training with the surgical robot on live animals under anesthesia in the laboratory, VII. Patient site assisting during robotic surgical procedures, VIII. Performing robotic surgery as a console surgeon under the supervision of a experienced mentor (fellowship program), IX. Assessing outcomes of the robotic surgical procedures (learning curve) and X. Ankara Ataturk Hospital Robotic Radical Prostatectomy Training Model. Training in robotic prostate cancer surgery includes a variety of modalities. Effective and sufficient training could be obtained with the combination of the suggested training modalities.Keywords: Training modalities, robotic surgery, prostate cancer surgery., Robotik cerrahi, tüm dünyada çeşitli hastalıkların cerrahi tedavisinde giderek artan sıklıkta uygulanmaktadır. Lokalize prostat kanseri tedavisinde radikal prostatektomi uzun süreli kanser kontrolü sağlamaktadır. İlk kez 2001 yılında uygulanmaya başlaması ile birlikte robotik radikal prostatektomi (RARP), hem hastalar hem de ürologlar tarafından prostat kanserinde tercih edilen ameliyat yöntemi haline gelmiştir. Bu modern ameliyat yönteminin eğitimi de oldukça önemli bir konudur. Bu makale, RARP ameliyat yönteminin eğitimi ile ilgili uluslararası literatür incelenerek, internet üzerinden robotik prostat kanseri cerrahisi eğitimi araştırılarak ve bu konuda eğitim veren merkezlerin eğitim programları incelenerek hazırlanmıştır. Robotik prostat kanseri cerrahisi eğitimi ile ilgili şu basamaklar özetlenmiştir; I. Ameliyatlara ait video izlemeye dayalı eğitim, II. Robotik cerrahi ile ilgili kurslara, sempozyumlara ve toplantılara katılmak, III. Ameliyathanede robotik cerrahi ameliyatlarını izlemek, IV. Simülatörler üzerinde eğitim almak, V. Çeşitli eğitim materyalleri üzerinde cerrahi eğitim ile eğitim yapmak, VI. Anestezi altındaki çeşitli hayvan modelleri üzerinde laboratuvarda cerrahi robot ile eğitim yapmak, VII. Robotik cerrahi ameliyatlarında hasta başında asistanlık yapmak, VIII. Bu konuda deneyimli bir cerrahın gözetiminde konsol başında bire bir cerrahi eğitim almak, IX. Öğrenme eğirişi döneminde cerrahın kendi sonuçlarını değerlendirmesi ve X. Ankara Atatürk Hastanesi Robotik Radikal Prostatektomi Eğitim Modeli. Robotik prostat kanseri eğitiminde birçok yöntem kullanılabilmektedir. Bu yöntemlerin bir arada kullanılması ile etkili ve yeterli eğitim sağlanabilmektedir
- Published
- 2015
18. Boyutu 3 cm ve küçük olan testis kitlelerinde, orşiektomi sonrası kitle patolojileri ile kitle dışı normal parankimde prekanseröz ve malign lezyonların retrospektif olarak araştırılması, bu kitlelerde testis koruyucu cerrahi uygulamanın yerinin değerlendirilmesi
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Keske, Murat, Canda, Abdullah Erdem, and Üroloji Anabilim Dalı
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Urology ,Üroloji - Abstract
Amaç: Bilateral testisi olan hastalarda, tek taraf testis tümörü için standart tedavi olan radikal inguinal orşiektominin yerini, özellikle küçük tümörlerde parsiyel orşiektominin alıp alamayacağı konusunda veri elde ederek fikir yürütmek ve ileride yapılacak çalışmalara ışık tutmak amacıyla çok merkezli bir çalışma gerçekleştirdik.Materyal ve Metod: Mart 2000- Ekim 2014 yılları arasında testiküler cerrahi geçirmiş hastaların, ülkemizden 11 ayrı merkezden toplanan patoloji sonuçları arasından 3 cm ve daha küçük boyuttaki testis kitlesine sahip 291'inin sonuçları derlendi. Tümör boyutu 3 ve altında olan bu hastalar kendi içinde kitle boyutu 0-1 cm (Grup 1, n=44), 1.1-2 cm (Grup 2, n=125), 2.1-3 cm (Grup 3, n=122) olarak 3 ayrı gruba ayrıldı. Hastaların sonuçları arasından benign olarak raporlananlar yanı sıra malign olarak raporlananların tümör çevresindeki normal testis parankiminde eşlik eden intratubüler germ hücreli neoplazi (ITGHN) veya malign tümör varlığı değerlendirildi. Patoloji sonuçlarından 112 tanesi bu merkezlerde bulunan uzman patologlar tarafından tekrar değerlendirildi.Bulgular: Ortalama hasta yaşı 32.3 (min 1, maks 79) idi. Radikal inguinal orşiektomi yapılan hastalarda tümör dışı testis parankiminde ITGHN saptanma oranı Grup 1'de (%20) Grup 2 (%42.4) ve Grup 3'e (%41.5) oranla anlamlı olarak daha düşük saptanmıştır (sırasıyla, p=0,031 ve p=0,034). Patolojik olarak tekrar incelenen hastalar arasında, kitle dışı testis parankiminde ITGHN oranlarına bakıldığında, ilk yapılan patolojik incelemede %48 olan ITGHN oranı tekrar yapılan patolojik inceleme sonrasında %55 olarak saptanarak artış saptanmıştır ancak bu fark anlamlı bulunmamıştır. (p=0.285). Tüm hastalar içinde, testisdeki kitlenin benign tümör saptanma oranı, patolojik boyutu 2 cm ve altında boyuta sahip tümörlerde anlamlı olarak daha yüksek saptanmıştır.Sonuç: Küçük testiküler kitlelerde, dikkatli seçilmiş hastalarda, testis koruyucu cerrahinin genel kurallara uyularak yapılması gündeme gelebilir.Anahtar kelimeler: Testis tümörüleri; parsiyel orşiektomi; testis koruyucu cerrahi; tümör boyutu. Purpose: The standart treatment of unilateral testicular tumours for patients with bilateral testis is radical inguinal orchiectomy. We aimed to determine if partial orchiectomy could take radical orchiectomy's place in small tumours. For this purpose we performed a multicenter study.Materials and Methods: Pathology results of the patients were included from 11 different centers in our country who underwent testiculer surgery between March 2000 and October 2014. Overall, 291 patients'results were included. Patients with tumor size of 3 cm or less were divided into 3 groups including 0-1 cm (Group 1, n=44), 1.1-2 cm (Group 2, n=125) and 2.1-3 cm (Group 3, n=122). In addition to benign pathology results, normal testicular parenchyma surrounding the tumor in malignant testis cancer were investigated for the presence of intratubuler germ cell neoplasia (ITGCN) or malignant tumor. 112 of the pathology reports were re-evaluated by the pathologist in these centers.Results: Mean patient age was 32.3 (min 1, max 79). In patients who underwent radical inguinal orchiectomy, at non-tumoral testis parenchyma, ITGHN detection rate was found significantly lower in Group 1 (20%) than Group 2 (42.4%) and Group 3 (41.5%) (p=0,031 and p=0,034, respectively). For the patients whose pathological reports were re-evaluated, ITGHN rate at the non-tumor testis parenchyma at first pathologic examination was 48%. After second pathologic examination this rate was found as 55%. ITGHN rate was higher in second examination but it was not statistically significant (p=0.285). In all patients, benign tumor detection rate was found significantly higher for 2 cm or smaller tumors.Conclusion: In carefully selected patients, testis sparing surgery can be performed for small testicular masses by complying general rules.Key Words: Testis tumors; Partial orchiectomy; testis sparing surgery; tumor size. 73
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- 2015
19. Relationship between oxidative stress and detrussor overactivity: a case control study.
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Keske, Murat, Gök, Bahri, Ener, Kemal, Özcan, Muhammet Fuat, Özayar, Asim, Okulu, Emrah, Neşelioğlu, Salim, Çakmak, Serdar, Asil, Erem, Aldemir, Mustafa, Erel, Özcan, Gok, Bahri, Ozcan, Muhammet Fuat, Ozayar, Asim, Neselioglu, Salim, Cakmak, Serdar, and Erel, Ozcan
- Subjects
- *
OXIDATIVE stress , *OXIDANT status , *HYPERKINESIA , *PARAOXONASE , *AGE groups , *CASE-control method , *OVERACTIVE bladder - Abstract
Purpose: We analyzed the role of oxidative stress in detrusor overactivity (DO) by measuring serum total antioxidant capacity (TAC), total oxidant status (TOS), binding capacity of exogenous cobalt to human albumin (IMA), serum advanced oxidation protein products (AOPP), paraoxonase (PON), and arylesterase.Materials and Methods: The study included 38 female patients diagnosed with DO and 29 healthy female subjects forming the control group. Serum total antioxidant capacity (TAC), total oxidant status (TOS), binding capacity of exogenous cobalt to human albumin (IMA), serum advanced oxidation protein products (AOPP), paraoxonase (PON), and arylesterase were analyzed. The results of serum TAC, TOS, IMA, AOPP, PON, and arylesterase of the subjects in both groups were compared.Results: There was no difference between the groups in terms of age. When compared to the control group, serum TAC and IMA levels were statisticaly lower (P < 0,001) and higher (P = 0,003), respectively. However, TOS, AOPP, PON, arylesterase levels were similar in both groups ( p > 0.05 ).Conclusion: There seems to be an association between DO and oxidative damage according to our results, this can be measured by analyzing TAC and IMA in this patient group. [ABSTRACT FROM AUTHOR]- Published
- 2019
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20. Testis-sparing surgery: Experience in 13 patients with oncological and functional outcomes.
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Keske, Murat, Canda, Abdullah Erdem, Atmaca, Ali Fuat, Cakici, Ozer Ural, Arslan, Muhammed Ersagun, Kamaci, Davut, and Balbay, Mevlana Derya
- Subjects
- *
LEYDIG cells , *IMPOTENCE , *TESTIS , *CASTRATION - Abstract
Introduction: We present oncological and functional outcomes of patients who underwent testis-sparing surgery (TSS). Methods: Overall, 13 patients were included. Mean patient age was 29.9±12.5 years. In five patients, TSS was performed for sequential bilateral testicular tumours. One patient underwent concurrent left radical orchiectomy and right TSS. In eight patients with normal contralateral testis, seven underwent left and one underwent right TSS. Results: Mean pathological tumour size was 14.6±12.5 mm. Intraoperative frozen section evaluation of the mass was performed in eight patients that revealed benign lesions. No intraoperative tumour bed biopsies were taken in this patient group. Regarding the remaining five patients, intraoperative tumour bed biopsies were taken and testicular intraepithelial neoplasia (TIN) was reported in two (40%) patients; no local testicular radiotherapy was given postoperatively. Tumour pathology was malignant in all but one lesion, including Leydig cell tumour (n=1), seminoma(n=2), embryonal carcinoma (n=1), and adenomatoid tumour (n=1). During 47.2±22.5 months of followup, local recurrence was detected in one patient who underwent radical orchiectomy. No additional local recurrence or systemic metastasis was identified in other patients with malignant lesions. For patients with malignant tumours, of the three patients with a normal preoperative testosterone levels, testosterone level was normal in one patient (with no erectile dysfunction [ED]) and was decreased in two patients (with ED) following TSS. No ED was reported in the nine patients with benign lesions. Conclusions: In carefully selected cases, TSS appears to be a safe, feasible procedure with adequate cancer control that could preserve sexual function. [ABSTRACT FROM AUTHOR]
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- 2019
- Full Text
- View/download PDF
21. Robotic radical cystectomy in bladder cancer: is it the future?
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Canda, Abdullah Erdem, Atmaca,Ali Fuat, Arslan,Muhammed Ersagun, Keske,Murat, Cakici,Ozer Ural, Cakmak,Serdar, Kamaci,Davut, and Urer,Emre
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Open Access Surgery - Abstract
Abdullah Erdem Canda,1 Ali Fuat Atmaca,1 Muhammed Ersagun Arslan,2 Murat Keske,2 Ozer Ural Cakici,2 Serdar Cakmak,2 Davut Kamaci,2 Emre Urer21Department of Urology, School of Medicine, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey; 2Department of Urology, Ankara Ataturk Training and Research Hospital, Ankara, TurkeyAbstract: Open radical cystectomy (RC) is the gold standard surgical approach in the management of muscle invasive bladder cancer in addition to high-grade, recurrent, noninvasive tumors. With the development of surgical robotic technology, robotic-assisted laparoscopic radical cystectomy (RARC) is increasingly being performed as a minimally invasive surgical approach. A learning curve exists with a recommended case number of at least 20 RARC procedures in order to achieve satisfying outcomes in terms of operation time, complication rate, and oncological outcomes, including positive surgical margins (SMs) and lymph node (LN) yield. In the current literature, long-term outcomes of RARC are not yet available. Due to the outcomes of the published literature, RARC seems to have satisfactory oncologic and functional outcomes in addition to acceptable complication rates. Intraoperative blood loss and transfusion rates seem to be decreased in RARC series when compared to open approaches. On the other hand, a number of authors have reported decreased complication rates but increased operation time in the robotic approach. Similar oncologic results including positive SM rates and LN yields were detected in most comparative publications. Totally intracorporeal RARC with urinary diversion is a complex procedure and the number of centers performing this type of surgery is currently very limited. Although, it is still too early to make strict conclusions about RARC, RARC with intracorporeal urinary diversion has the potential to be the future of robotic bladder cancer surgery. Therefore, further prospective and randomized studies with increased numbers of patients and with longer follow-up are needed. Lastly, RARC may be related to increased cost when compared to open surgery, although controversial reports exist about this issue.Keywords: intracorporeal urinary diversion, outcomes, open versus robotic, robotic surgery
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- 2014
22. PENİSİN MONDOR HASTALIĞI: VAKA SUNUMU
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ENER, Kemal, OKULU, Emrah, ALDEMİR, Mustafa, AKDEMİR, Fatih, KESKE, Murat, and ÖZCAN, Muhammed Fuat
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penis,mondor\'s disease,thrombophlebitis ,penis,mondor hastalığı,tromboflebit - Abstract
İntroduction: Mondor, first described a sclerosing thrombophlebitis of the veins of the anterior chest wall in 1938. Despite the etiology is unknown in most cases, various authors have proposed some new etiologies indicating trauma during sexual intercourse as causative factors. In this case report, it has been aimed to remind the thrombophlebitis of the superficial dorsal vein of the penis. Case report: A 36 years old patient with Mondor's disease, was treated with heparin pomades and limiting of sexual intercourse successfully. Discussion: Superficial penile dorsal vein trombosis is a benign pathology and it is not associated with any systemic and malign disorders. Diagnosis depends on a detailed patient history and physical examinatiton. Thus Mondor's Disease is self limited, it is thought that many of the patients with this disease are healed without applying to a hospital., Giriş: Yüzeyel venlerin trombozu, ilk kez Mondor tarafından 1938'de göğüs duvarında tanımlanmıştır. Mondor Hastalığı'nda çoğu kez etyoloji bilinmemekle beraber, cinsel ilişki sırasında peniste oluşan travma sorumlu gösterilmektedir. Bu olgu sunumunda, penisin yüzeyel dorsal veninin tromboflebitinin tekrar hatırlatılması amaçlanmıştır. Olgu sunumu: Polikliniğimize başvuran ve Mondor hastalığı tespit edilen 36 yaşındaki erkek hasta heparin içeren jel ve cinsel ilişki kısıtlanması ile başarılı bir şekilde tedavi edildi. Tartışma: Yüzeyel penil dorsal ven trombozu benign bir patoloji olup, sistemik ve malign hastalıklarla hastalıklarla bir ilişkisi bulunmamaktadır. İyi bir anamnez ve fizik muayene ile kolayca teşhis edilebilen bir hastalıktır. Kendi kendini sınırlayan bir hastalık olması nedeniyle, Penisin Mondor Hastalığı gelişen birçok hastanın polikliniğe başvurmadan iyileştiği düşünülmektedir.
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- 2014
23. Robotic radical cystectomy in bladder cancer: is it the future?
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Canda,Abdullah Erdem, Atmaca,Ali Fuat, Arslan,Muhammed Ersagun, Keske,Murat, Cakici,Ozer Ural, Cakmak,Serdar, Kamaci,Davut, Urer,Emre, Canda,Abdullah Erdem, Atmaca,Ali Fuat, Arslan,Muhammed Ersagun, Keske,Murat, Cakici,Ozer Ural, Cakmak,Serdar, Kamaci,Davut, and Urer,Emre
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Abdullah Erdem Canda,1 Ali Fuat Atmaca,1 Muhammed Ersagun Arslan,2 Murat Keske,2 Ozer Ural Cakici,2 Serdar Cakmak,2 Davut Kamaci,2 Emre Urer21Department of Urology, School of Medicine, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey; 2Department of Urology, Ankara Ataturk Training and Research Hospital, Ankara, TurkeyAbstract: Open radical cystectomy (RC) is the gold standard surgical approach in the management of muscle invasive bladder cancer in addition to high-grade, recurrent, noninvasive tumors. With the development of surgical robotic technology, robotic-assisted laparoscopic radical cystectomy (RARC) is increasingly being performed as a minimally invasive surgical approach. A learning curve exists with a recommended case number of at least 20 RARC procedures in order to achieve satisfying outcomes in terms of operation time, complication rate, and oncological outcomes, including positive surgical margins (SMs) and lymph node (LN) yield. In the current literature, long-term outcomes of RARC are not yet available. Due to the outcomes of the published literature, RARC seems to have satisfactory oncologic and functional outcomes in addition to acceptable complication rates. Intraoperative blood loss and transfusion rates seem to be decreased in RARC series when compared to open approaches. On the other hand, a number of authors have reported decreased complication rates but increased operation time in the robotic approach. Similar oncologic results including positive SM rates and LN yields were detected in most comparative publications. Totally intracorporeal RARC with urinary diversion is a complex procedure and the number of centers performing this type of surgery is currently very limited. Although, it is still too early to make strict conclusions about RARC, RARC with intracorporeal urinary diversion has the potential to be the future of robotic bladder cancer surgery. Therefore, further prospective and randomized s
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- 2014
24. The impact of 120 watt and 160 watt monopolar transurethral prostatectomy on erectile function
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ENER, Kemal, OKULU, Emrah, ALDEMİR, Mustafa, AKDEMİR, Fatih, KESKE, Murat, ÖZCAN, Muhammet Fuat, and ALTINOVA, Serkan
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monopolar TURP,erectile dysfunction ,monopolar TURP,erektil disfonksiyon ,urologic and male genital diseases - Abstract
Amaç: Monopolar transüretral prostatektomi TURP ’de 120 watt ve 160 watt enerji kullanımının, ereksiyon üzerine olan etkilerini incelemeyi amaçladık. Gereç ve Yöntemler: Benign Prostat Hiperplazisi BPH nedeniyle monopolar TURP yapılan, cinsel yönden aktif 47 hasta, kesme için kullanılan enerji miktarına göre 120 watt n=21 ve 160 watt n=26 , gruplarına randomize edildi. Hastalar, preoperatif ve postoperatif 3. ayda, IIEF-5 ve IIEF-15 sorgulama formları ile cinsel disfonksiyon yönünden değerlendirildi. Bulgular: Hastaların yaş ortalaması, sırasıyla 120 watt grubunda 64.2±5.3, 160 watt grubunda ise 62.7±0.9 yıl idi. TURP sonrasında her 2 gruptaki hastaların işeme parametreleri, istatistiksel olarak anlamlı düzelme gösterdi. Bununla beraber, TURP sonrası 3. ayda, her 2 gruptaki hastaların IIEF-5 ve IIEF-15 skorları, ameliyat öncesi döneme göre anlamlı olarak azaldı. Sonuçlar: Monopolar TURP sonrası IIEF5 ve 15 skorları, kullanılan enerji miktarından bağımsız olarak 3. ayda azalmakla beraber, BPH tedavisinde etkin bir yöntem olan TURP’nin, erektil disfonksiyon oluşturup oluşturmadığı halen tartışmalı bir konudur., Objective: We aimed to analyze the effect of 120 watt and 160 watt energy on erectile function used during monopolar transurethral prostatectomy TURP . Material and Methods: A total of sexually active 47 male patients, undergoing monopolar TURP because of Benign Prostatic Hyperplasia BPH , were randomised into 120 watt n=21 , and 160 watt n=26 groups, in terms of the amount of energy used for prostatic tissue cutting. The patients were evaluated with IIEF-5 and IIEF-15 questionnaires, preoperatively and in the postoperative 3rd month concerning erectile function. Results: The mean age of the patients was 64.2±5.3 and 62.7±0.9 years, in the 120 watt and 160 watt groups respectively. The voiding parameters showed statistically significantly improvement in both groups after TURP. Nevertheless, 3 months after the TURP, IIEF-5 and IIEF-15 scores of the patients decreased significantly in both groups compared with the preoperative period. Conclusions: Although, in the 3rd month evaluation after monopolar TURP, IIEF-5 and IIEF-15 scores of the patients decrease, regardless of the amount of energy used, it is still a debated issue, whether TURP causes erectile dysfunction as an effective treatment option for BPH
25. Efficacy of Alfuzosin in Male Patients with Moderate Lower Urinary Tract Symptoms: Is Metabolic Syndrome a Factor Affecting the Outcome?
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Sonmez, Gokhan, Topaloglu, Ulas Serkan, Keske, Murat, and Demirtas, Abdullah
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URINARY organs , *METABOLIC syndrome , *SYMPTOMS , *BENIGN prostatic hyperplasia , *ADRENERGIC alpha blockers , *HETEROCYCLIC compounds , *TREATMENT effectiveness , *SEVERITY of illness index , *LONGITUDINAL method - Abstract
Purpose: The present study was designed to compare the efficacy of alfuzosin therapy as an alpha-blocker in metabolic syndrome (MetS) and non-MetS patients with moderate lower urinary tract symptoms (LUTS).Material and Methods: This prospective study included male patients with obstructive voiding and had a moderate LUTS according to International Prostate Symptom Score (IPSS). Patients were divided into two groups: MetS and Non-MetS. Following the measurement of uroflowmetric parameters (maximum flow rate [Qmax], post-void residual volume [PVR], urine volume) and the determination of IPSS scores, the patients were initiated on alfuzosin 10 mg once daily for a period of 12 weeks. At the end of the therapy, treatment outcomes were determined based on uroflowmetric parameters and IPSS scores.Results: 301 patients were included in the study (MetS: 160, non-MetS: 141). Pre-treatment uroflowmetric measurements and IPSS scores were similar in both groups. After the therapy, the median Qmax level increased from 12.80 (10.62-14.82) ml/s to 14.55 (12.00-16.60) ml/s in the MetS group and from 12.60 (8.60-14.60) ml/s to 15.70 (13.20-17.20) ml/s in the non-MetS group (p<0.001 for both). Similar statistically significant changes were valid for PVR and IPSS. Post-treatment Qmax, PVR values and IPSS scores were higher in the non-MetS patients compared to MetS patients.Conclusion: Although the non-MetS patients had greater benefit from the alfuzosin therapy compared to the MetS patients, alfuzosin is an effective alpha-blocker in the treatment of MetS patients with moderate LUTS. Based on these findings, it is tempting to consider that MetS might be a negative factor for benign prostate hyperplasia treatment. [ABSTRACT FROM AUTHOR]- Published
- 2020
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26. Concurrent Repair of Inguinal Hernias with Mesh Application During Transperitoneal Robotic-assisted Radical Prostatectomy: Is it Safe?
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Atmaca, Ali Fuat, Hamidi, Nurullah, Canda, Abdullah Erdem, Keske, Murat, and Ardicoglu, Arslan
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INGUINAL hernia , *PROSTATECTOMY , *SURGICAL robots , *DISEASE relapse , *CATHETERIZATION - Abstract
Purpose: To assessment the safety of concurrent repair of inguinal hernia (IH) with mesh application during transperitoneal robotic-assisted radical prostatectomy(RARP). Materials and Methods: Data of 20 patients (totally 25 procedures) who performed concurrent IH repair with mesh application during RARP were retrospectively enrolled in this study. Preoperative patient characteristics, intra and postoperative parameters (pathological Gleason grade, prostate volume at surgical specimen, operative time, herniorrhaphy time, estimated blood loss, complications, time of hospitalization, catheterization, and drainage) were evaluated. Standard PSA control and postoperative complications of mesh application such as hernia recurrence, mesh infection, seroma formation and groin pain were evaluated at every follow-up visits (every three in the first year, then every 6 months in years 2 to 5 and annually thereafter. Result: The mean age was 66 ± 8 years in our population. Fifteen (60 %) patients had a unilateral hernia and 5 (40 %) patients had bilateral hernias. The mean operative time was 139 ± 21minutes and estimated mean blood loss was 108 ± 76 mL. The mean duration of IH repair in patients which was 27 ± 5 (range: 17- 40) minutes. The mean time of drainage, hospitalization, and catheterization were 2.5 ± 0.8 days (range: 2-6), 4 ± 0.9 days (range: 2-7) and 8.2 ± 1.9 days (range: 7-14), respectively. We did not observe any intra-operative complication due to RARP or IH repair. Wound evisceration at camera port site developed in only a patient on postoperative day 20. Our median follow-up time was 13 months and we did not observe mesh infection or hernia recurrence during follow-up. Conclusion: Concurrent IH repair with RARP procedure seem to be easy to perform, effective and safe procedure. [ABSTRACT FROM AUTHOR]
- Published
- 2018
27. Does Presence of a Median Lobe Affect Perioperative Complications, Oncological Outcomes and Urinary Continence Following Robotic-assisted Radical Prostatectomy?
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Hamidi, Nurullah, Atmaca, Ali Fuat, Canda, Abdullah Erdem, Keske, Murat, Gok, Bahri, Koc, Erdem, Asil, Erem, and Ardicoglu, Arslan
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- *
PROSTATECTOMY , *SURGICAL robots , *SURGICAL site infections , *SURGICAL complications , *CANCER relapse - Abstract
Purpose: To evaluate of the presence of a median lobe(ML) affect perioperative complications, positive surgical margins(PSM), biochemical recurrence(BCR) and urinary continence(UC) following robotic-assisted radical prostatectomy( RARP). Materials and Methods: Data of 924 consecutive patients who underwent RARP for prostate cancer (PCa) and who have at least 1-year follow-up were evaluated retrospectively. All patients were divided into two groups: Group 1(n=252) included patients with ML and Group 2 (n=672) included patients without ML. The primary endpoint of this study was to compare complication rates between two groups. The secondary endpoints were to compare PSM, BCR and UC rates. Result: Both groups were statistically similar in terms of demographics and variables about PCa. Mean prostate volume was higher in Group 1 vs. Group 2 (69 ± 31 vs. 56 ± 23 mL, p < .001). Total operative time was longer in Group 1 vs. Group 2 (144 ± 38 vs. 136 ± 44 min, p = .01). Biochemical recurrence, PSM, perioperative and postoperative complication rates of our population were 13.6%, 14.9%, 1.7% and 8.7%, respectively. There were no statistical differences in terms of perioperative complication, PSM and BCR rates between the groups(p > 0.05). At the first month after RARP, total continence rate was statistically significant lower in Group 1 vs. Group 2 (49.2% and 56.5%, p = .03), respectively. However, there were no significant differences in terms of continence rates at 3rd month, 6th month and 1st-year follow-up. Conclusion: Due to our experience, the presence of ML does not seem to affect perioperative complication, intraoperative blood loss, PSM and BCR following RARP. However, the presence of ML seems to be a disadvantage in gaining early UC following RARP. [ABSTRACT FROM AUTHOR]
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- 2018
28. Robotic radical prostatectomy in 93 cases: outcomes of the first ERUS robotic urology curriculum trained surgeon in Turkey
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Fevzi Bedir, Abdullah Erdem Canda, Erdem Koc, Saban Oguz Demirdogen, Ali Fuat Atmaca, Hüseyin Kocatürk, Murat Keske, Canda, Abdullah Erdem (ORCID 0000-0002-5196-653X & YÖK ID 116202), Bedir, Fevzi, Keske, Murat, Demirdöğen, Şaban Oğuz, Kocatürk, Hüseyin, Koç, Erdem, Atmaca, Ali Fuat, School of Medicine, and Department of Urology
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Biochemical recurrence ,medicine.medical_specialty ,Prostate biopsy ,medicine.diagnostic_test ,Prostatectomy ,business.industry ,Incisional hernia ,medicine.medical_treatment ,Medicine ,Urology and nephrology ,Urology ,Perioperative ,Neurovascular bundle ,medicine.disease ,Inguinal hernia ,medicine ,ERUS ,Outcomes ,Robotic radical prostatectomy ,Training ,Robotic surgery ,business ,Urooncology - Abstract
Objective: this study presents the surgical, oncological, and functional outcomes of the first 93 robotic radical prostatectomy (RARP) procedures performed in Erzurum, Turkey. These procedures were performed by a single surgeon who had completed the European Association of Urology Robotic Urology Section (ERUS) RA RP curriculum in an ERUS-certified training center in Ankara. Material and methods: The study present the results of 93 RARP procedures performed by a single surgeon. The surgeon performing the operations completed an ERUS training program structured for RARP by two robotic surgeons holding ERUS training certificates in an ERUS-approved academic robotic surgery training center in Ankara.The RARP cases performed by the surgeon after completion of the training between April 2016 and August 2018 were retrospectively evaluated. Results: the mean patient age was 63.62 +/- 7.04 years, and the mean preoperative serum prostate-specific antigen level was 8.34 +/- 496 ng/mL. Preoperatively, 82 and 4 patients had prostate biopsy Gleason scores of 3+3 and 4+3, respectively. Bilateral neurovascular bundle (NVB) sparing, unilateral NVB-sparing, and non-NVB-sparing surgery were performed in 21, 13, and 59 cases, respectively. The mean prostate weight was 85.34 +/- 47.57 g Posterior rhabdosphincter reconstruction was performed in 60 (64.5%) cases. Mean console time, intraoperative blood loss, duration of hospital stay, and urethral catheter removal time were 170.49 +/- 36.50 min, 100.70 +/- 34.08 cc, 6.84 +/- 2.28 days, and 7.40 +/- 3.11 days, respectively. During the perioperative period (0-30 days), five minor (prolonged drain output, n=3; rectocele, n=1; gout arthritis, n=1) and six major (inguinal hernia, n=1; incisional hernia, n=2; anastomotic urinary leakage, n=2; myocardial infarction, n=1) complications were identified. No complication was detected during postoperative days 31-90. Postoperative pathological stages included pT'2a, pT2b, and pT2c disease in 77 (82.8%), 9 (9.7%), and 7 (7.5%) patients, respectively. The positive surgical margin (SM) rate was 10.7% (n=10), including patients with pT2a (n=6) and pT2c (n=2) diseases. Eleven (11.8%) patients underwent pelvic lymph node (LN) dissection. The mean LN yield was 16.45 +/- 429. The mean length of follow-up was 11.17 +/- 8.01 months. Biochemical recurrence was observed in two patients, one of whom received maximal androgen blockage (MAB), and the other one received pelvic radiotherapy+MAB. All the patients with at least one-year follow-up (n=48, 51.6%) were fully continent (0 pads/day). Of the 40 (43%) patients with no preoperative erectile dysfunction (ED) and with at least three-month follow-up, 18 (45%) had no ED, with or without any additional medication including phosphodiesterase-5 (PDES) inhibitors. Conclusion: RARP is a safe minimally invasive procedure with acceptable morbidity, excellent operative, pathological and oncological outcomes, and satisfactory functional results. The ERUS RARP curriculum provides effective and sufficient training., NA
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- 2019
29. Re: Testis-Sparing Surgery: Experience in 13 Patients with Oncologic and Functional Outcomes
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Ozer Ural Cakici, M.E. Arslan, D. Kamaci, Murat Keske, Ali Fuat Atmaca, Mevlana Derya Balbay, Abdullah Erdem Canda, Canda, Abdullah Erdem (ORCID 0000-0002-5196-653X & YÖK ID 116202), Balbay, Mevlana Derya ( ORCID 0000-0001-9706-1587 & YÖK ID 153320), Keske, Murat, Atmaca, Ali Fuat, Çakıcı, Özer Ural, Arslan, Muhammed Ersagun, Kamacı, Davut, School of Medicine, and Department of Urology
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medicine.medical_specialty ,Small testicular masses ,Germ-cell tumors ,Benign ,Lesions ,Cancer ,medicine.medical_treatment ,Medicine ,Urology and nephrology ,Urology ,Testis sparing surgery ,030232 urology & nephrology ,Leydig cell tumour ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,medicine ,Pathological ,Original Research ,Frozen section procedure ,business.industry ,Seminoma ,medicine.disease ,Surgery ,Radiation therapy ,Erectile dysfunction ,Oncology ,030220 oncology & carcinogenesis ,medicine.symptom ,Sexual function ,business - Abstract
Introduction: we present oncological and functional outcomes of patients who underwent testis-sparing surgery (TSS). Methods: overall, 13 patients were included. Mean patient age was 29.9 +/- 12.5 years. In five patients, TSS was performed for sequential bilateral testicular tumours. One patient underwent concurrent left radical orchiectomy and right TSS. In eight patients with normal contralateral testis, seven underwent left and one underwent right TSS. Results: mean pathological tumour size was 14.6 +/- 12.5 mm. lntraoperative frozen section evaluation of the mass was performed in eight patients that revealed benign lesions. No intraoperative tumour bed biopsies were taken in this patient group. Regarding the remaining five patients, intraoperative tumour bed biopsies were taken and testicular intraepithelial neoplasia (TIN) was reported in two (40%) patients; no local testicular radiotherapy was given postoperatively. Tumour pathology was malignant in all but one lesion, including Leydig cell tumour (n=1), seminoma(n=2), embryonal carcinoma (n=1), and adenomatoid tumour (n=1). During 47.2 +/- 22.5 months of followup, local recurrence was detected in one patient who underwent radical orchiectomy. No additional local recurrence or systemic metastasis was identified in other patients with malignant lesions. For patients with malignant tumours, of the three patients with a normal preoperative testosterone levels, testosterone level was normal in one patient (with no erectile dysfunction [ED]) and was decreased in two patients (with ED) following TSS. No ED was reported in the nine patients with benign lesions. Conclusions: in carefully selected cases, TSS appears to be a safe, feasible procedure with adequate cancer control that could preserve sexual function., NA
- Published
- 2019
30. Prone versus Barts “flank-free” modified supine percutaneous nephrolithotomy: a match-pair analysis
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Miçooğulları U, Kamacı D, Yıldızhan M, Umut Kılıç F, Çetin T, Çakıcı ÖU, Keske M, Yiğit Yalçın M, and Ardıçoğlu A
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- Adult, Female, Humans, Male, Middle Aged, Patient Positioning, Retrospective Studies, Supine Position, Treatment Outcome, Kidney Calculi surgery, Nephrolithotomy, Percutaneous adverse effects
- Abstract
Background/aim: In this study, we aimed to compare the results of prone and Barts “flank-free” modified supine percutaneous nephrolithotomy (PCNL) operations in our clinic., Materials and Methods: The data from patients that underwent Barts “flank-free” modified supine PCNL (BS-PCNL) (n = 52) between June 2018 and July 2020 and prone PCNL (P-PCNL) (n = 286) between April 2014 and June 2018 were retrospectively evaluated. Of those 286 patients, 104 patients whose sex, age, body mass index, American Society of Anesthesiology score, stone localization, stone size, and hydronephrosis matched the BS-PCNL group in a 1:2 ratio were included in the study. The groups were compared in terms of intraoperative outcome, complication rates, and stone-free rates., Results: The mean age of all patients (58 females, 98 males) included in the study was 41.8 ± 15.2 years, and the mean body mass index (BMI) was 24.7 ± 2.9 kg/m2. The mean operation time was significantly shorter in the BS-PCNL group than in the P-PCNL group (80.2 ± 15.1 min vs. 92.4 ± 22.7 min and p = 0.01). There was no significant difference between the two groups in terms of fluoroscopy time, intraoperative complications, postoperative complications, and stone-free rates., Conclusion: Our study shows that BS-PCNL is an effective and safe method that significantly reduces the operation time and should be considered as one of the primary treatment options for patients scheduled for PCNL., Competing Interests: none declared., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
- Published
- 2021
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31. Does extent of prostate-specific antigen fluctuation can predict Gleason score upgrading in low-risk prostate cancer patients?
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Hamidi N, Atmaca AF, Canda AE, Keske M, and Ardıçoğlu A
- Abstract
Objective: To evaluate the effect of prostate-specific antigen (PSA) fluctuation on Gleason score (GS) upgrading, disease upstaging, oncological outcomes in low-risk prostate cancer (PCa) patients who underwent robot-assisted laparoscopic radical prostatectomy (RARP) and met the inclusion criteria for active surveillance (AS)., Material and Methods: Data of 354 low-risk PCa patients who underwent RARP were retrospectively evaluated. Patients were divided into two groups: PSA fluctuation rate<9.5%/month (Group 1, n=192) and >9.5%/month (Group 2, n=162). Mainly compared parameters were GS upgrading, disease upstaging, biochemical recurrence (BCR) and surgical margin positivity (SMP) rates., Results: GS upgrading, disease upstaging and SMP were detected in 128 (36.2%), 56 (15.8%) and 42 (11.9%) patients, respectively. After a median follow-up of 46 months, BCR was observed in 40 (11.3%) patients. GS upgrading (41.1% vs. 30.2%, p=0.033), disease upstaging (19.8% vs. 11.1%, p=0.028), SMP (15.1% vs. 8%, p=0.035) and BCR development (15.6% vs. 6.2%, p=0.005) rates were statistically significantly higher in Group 1 than Group 2. In multivariate analysis, digital rectal examination positivity, the presence of two positive cores and low PSA fluctuation rate were found to be significant predictors of GS upgrading., Conclusion: Low PSA fluctuation rate is associated with higher GS upgrading.
- Published
- 2019
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32. Robotic radical prostatectomy in 93 cases: Outcomes of the first ERUS robotic urology curriculum trained surgeon in Turkey.
- Author
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Bedir F, Keske M, Demirdöğen ŞO, Kocatürk H, Koç E, Canda AE, and Atmaca AF
- Abstract
Objective: This study presents the surgical, oncological, and functional outcomes of the first 93 robotic radical prostatectomy (RARP) procedures performed in Erzurum, Turkey. These procedures were performed by a single surgeon who had completed the European Association of Urology Robotic Urology Section (ERUS) RARP curriculum in an ERUS-certified training center in Ankara., Material and Methods: The study present the results of 93 RARP procedures performed by a single surgeon. The surgeon performing the operations completed an ERUS training program structured for RARP by two robotic surgeons holding ERUS training certificates in an ERUS-approved academic robotic surgery training center in Ankara. The RARP cases performed by the surgeon after completion of the training between April 2016 and August 2018 were retrospectively evaluated., Results: The mean patient age was 63.62±7.04 years, and the mean preoperative serum prostate-specific antigen level was 8.34±4.96 ng/mL. Preoperatively, 82 and 4 patients had prostate biopsy Gleason scores of 3+3 and 4+3, respectively. Bilateral neurovascular bundle (NVB) sparing, unilateral NVB-sparing, and non-NVB-sparing surgery were performed in 21, 13, and 59 cases, respectively. The mean prostate weight was 85.34±47.57 g. Posterior rhabdosphincter reconstruction was performed in 60 (64.5%) cases. Mean console time, intraoperative blood loss, duration of hospital stay, and urethral catheter removal time were 170.49±36.50 min, 100.70±34.08 cc, 6.84±2.28 days, and 7.40±3.11 days, respectively. During the perioperative period (0-30 days), five minor (prolonged drain output, n=3; rectocele, n=1; gout arthritis, n=1) and six major (inguinal hernia, n=1; incisional hernia, n=2; anastomotic urinary leakage, n=2; myocardial infarction, n=1) complications were identified. No complication was detected during postoperative days 31-90. Postoperative pathological stages included pT2a, pT2b, and pT2c disease in 77 (82.8%), 9 (9.7%), and 7 (7.5%) patients, respectively. The positive surgical margin (SM) rate was 10.7% (n=10), including patients with pT2a (n=6) and pT2c (n=2) diseases. Eleven (11.8%) patients underwent pelvic lymph node (LN) dissection. The mean LN yield was 16.45±4.29. The mean length of follow-up was 11.17±8.01 months. Biochemical recurrence was observed in two patients, one of whom received maximal androgen blockage (MAB), and the other one received pelvic radiotherapy+MAB. All the patients with at least one-year follow-up (n=48, 51.6%) were fully continent (0 pads/day). Of the 40 (43%) patients with no preoperative erectile dysfunction (ED) and with at least three-month follow-up, 18 (45%) had no ED, with or without any additional medication including phosphodiesterase-5 (PDE5) inhibitors., Conclusion: RARP is a safe minimally invasive procedure with acceptable morbidity, excellent operative, pathological and oncological outcomes, and satisfactory functional results. The ERUS RARP curriculum provides effective and sufficient training.
- Published
- 2019
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33. Open stone surgery: a still-in-use approach for complex stone burden.
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Çakici ÖU, Ener K, Keske M, Altinova S, Canda AE, Aldemir M, and Ardicoglu A
- Abstract
Introduction: Urinary stone disease is a major urological condition. Endourologic techniques have influenced the clinical approach and outcomes. Open surgery holds a historic importance in the management of most conditions. However, complex kidney stone burden may be amenable to successful results with open stone surgery. In this article, we report our eighteen cases of complex urinary stone disease who underwent open stone removal., Material and Methods: A total of 1701 patients have undergone surgical treatment for urinary stone disease in our clinic between July 2012 and July 2016, comprising eighteen patients who underwent open stone surgery. Patients' demographic data, stone analysis results, postoperative clinical data, and stone status were evaluated retrospectively. The choice of surgical approach is mostly dependent on the surgeon's preference. In two patients, open surgery was undertaken because of perioperative complications., Results: We did not observe any Clavien-Dindo grade 4 or 5 complications. Three patients were managed with a course of antibiotics due to postoperative fever. One patient had postoperative pleurisy, one patient had urinoma, and two patients had postoperative ileus. Mean operation time was 84 (57-124) minutes and mean hospitalization time was 5.5 (3-8) days. Stone-free status was achieved in 15 patients (83.3%)., Conclusions: Endourologic approaches are the first options for treatment of urinary stone disease. However, open stone surgery holds its indispensable position in complicated cases and in complex stone burden. Open stone surgery is also a valid alternative to endourologic techniques in all situations., Competing Interests: The authors declare no conflicts of interest.
- Published
- 2017
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34. Does anterior prostatic fat tissue removed during robotic radical prostatectomy contain any lymph nodes?
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Atmaca AF, Canda AE, Keske M, Arslan ME, Kamaci D, Alkan E, and Balbay MD
- Abstract
Introduction: We investigated whether anterior periprostatic fat (APPF) tissue removed during robotic radical prostatectomy (RARP) contains any lymph nodes (LNs)., Material and Methods: APPF tissues removed during RARP in 129 patients were evaluated histopathologically. Correlation with postoperative pathologic stage was made. Patients with a history of previous prostate or bladder surgery and radiation therapy were excluded., Results: Mean patient age, serum prostate specific antigen (PSA), prostate weight and body mass index (BMI) were 62.2 ±5.5 (range 45-74), 9.3 ±6.3 ng/dl (range 0.26-30.3), 60.3 ±27.2 grams (range 11.0-180) and 26.6 ±1.9 kg/m(2) (range 20.0-30.3), respectively. Overall, LNs in APPF tissues were detected in 14 (10.9%) patients with a mean LN yield of 1.1 ±0.7 LNs (range, 1-3). Among those found, no metastatic LN was detected. Of the patients with pT2a (n = 22), pT2b (n = 15), pT2c (n = 62) and pT3a (n = 21) disease, LNs in APPF tissues were detected in 1 (4.6%), 1 (6.7%), 11 (17.7%) and 1 (4.8%) patient in each group, respectively. Among the patients, LNs in APPF tissues were detected in 0 (0%), 5 (35.7%), 8 (57.1%) and 1 (7.1%) patients of underweight, optimal weight, overweight and obese patients due to body mass index, respectively., Conclusions: In our series, LNs were detected in around 10% of the patients. Therefore, this fat should, not be pushed back during RARP but should be removed and sent for pathologic evaluation. Although no metastatic LN was detected in our series, the presence of metastatic LNs might have an impact on the oncologic outcomes of the patients and warrants further research.
- Published
- 2015
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