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2. On the Hill's Spherical Vortex in Fluid and Plasma, its Generalization, and Stability

Author

Keller, Jason M. and Cheviakov, Alexei F.

Subjects
Physics - Fluid Dynamics
Abstract

In 1894 M.J.M. Hill published an article describing a spherical vortex moving through a stationary fluid. Using cylindrical coordinates and assuming the azimuthal velocity component zero, Hill found a simple solution that described this flow. A similar modern problem in the MHD framework was put forth in 1987 by A. A. Bobnev and in 1995 by R. Kaiser and D. Lortz who applied the setup to model a ball lighting. We present a much simpler derivation of Hill's spherical vortex using the Bragg-Hawthorne equation. In particular, by using the moving frame of reference, the Euler equations reduce to equilibrium flow which are equivalent to the static equilibrium MHD equations up to relabelling. A new generalized version of Hill's spherical vortex with a nonzero azimuthal component is derived. A physical solution to the static equilibrium MHD equations is computed by looking at a separated solution to the Grad-Shafranov equation in spherical coordinates. Finally, the stability of Hill's spherical vortex is examined by performing an axisymmetric perturbation described; it is shown that the Hill's spherical vortex is linearly unstable with respect to certain kinds of small perturbations.

Published
2022

3. New Exact Plasma Equilibria with Axial and Helical Symmetry

Author

Keller, Jason M. and Cheviakov, Alexei F.

Subjects
Physics - Plasma Physics
Abstract

Exact solutions to the static equilibrium magnetohydrodynamic equations are presented and discussed for both axially and helically reduced systems. For both symmetries, physical restrictions on the solutions are discussed and it is seen that there arise two different families of physical solutions corresponding to two distinct pressure profiles. One is suitable for atmospherically confined plasma whereas the other is suitable for plasma residing in a vacuum. For solutions in vacuum, the radial dependence is found to behave periodically for both axial and helical symmetries. For these physical solutions, only a truncated solution inside of some chosen domain can be considered. The magnetic field boundary can than be described by a current sheet. In the last part of the paper, these static equilibrium solutions are transformed into solutions with non-zero fluid velocity.

Published
2022

5. Soil metabolome response to whole-ecosystem warming at the Spruce and Peatland Responses under Changing Environments experiment

Author

Wilson, Rachel M., Tfaily, Malak M., Kolton, Max, Johnston, Eric R., Petro, Caitlin, Zalman, Cassandra A., Hanson, Paul J., Heyman, Heino M., Kyle, Jennifer E., Hoyt, David W., Eder, Elizabeth K., Purvine, Samuel O., Kolka, Randall K., Sebestyen, Stephen D., Griffiths, Natalie A., Schadt, Christopher W., Keller, Jason K., Bridgham, Scott D., Chanton, Jeffrey P., and Kostka, Joel E.

Published
2021

6. Voluntary urination control by brainstem neurons that relax the urethral sphincter

Author

Keller, Jason A, Chen, Jingyi, Simpson, Sierra, Wang, Eric Hou-Jen, Lilascharoen, Varoth, George, Olivier, Lim, Byung Kook, and Stowers, Lisa

Subjects
Neurosciences, Animals, Brain Stem, Electromyography, Estrogen Receptor alpha, Male, Mice, Neural Pathways, Neurons, Odorants, Optogenetics, Urethra, Urination, Urination Disorders, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Voluntary urination ensures that waste is eliminated when safe and socially appropriate, even without a pressing urge. Uncontrolled urination, or incontinence, is a common problem with few treatment options. Normal urine release requires a small region in the brainstem known as Barrington's nucleus (Bar), but specific neurons that relax the urethral sphincter and enable urine flow are unknown. Here we identify a small subset of Bar neurons that control the urethral sphincter in mice. These excitatory neurons express estrogen receptor 1 (BarESR1), project to sphincter-relaxing interneurons in the spinal cord and are active during natural urination. Optogenetic stimulation of BarESR1 neurons rapidly initiates sphincter bursting and efficient voiding in anesthetized and behaving animals. Conversely, optogenetic and chemogenetic inhibition reveals their necessity in motivated urination behavior. The identification of these cells provides an expanded model for the control of urination and its dysfunction.

Published
2018

7. Ultrarapid Measurement of Diagnostic Antibodies by Magnetic Capture of Immune Complexes.

Author

Burbelo, Peter D, Gunti, Sreenivasulu, Keller, Jason M, Morse, Caryn G, Deeks, Steven G, Lionakis, Michail S, Kapoor, Amit, Li, Qingxue, Cohen, Jeffrey I, Notkins, Abner L, and Alevizos, Ilias

Subjects
Humans, Sjogren's Syndrome, Bacterial Proteins, Staphylococcal Protein A, Autoantibodies, Antigen-Antibody Complex, Point-of-Care Systems, Female, Male, Magnetic Fields, Sjogrens Syndrome
Abstract

Rapid point-of-care, antibody-based testing is not currently available for the diagnosis of most autoimmune and infectious diseases. Here we report a simple, robust and ultrafast fluid-phase immunocapture method for clinical measurements of antibody levels. This method employs neodymium magnetic sticks that capture protein A/G-coated paramagnetic beads bound to antibody-luciferase-labeled antigen complexes. We demonstrate the ability to effectively measure specific antibody levels in serum samples from patients with varied infectious or autoimmune disorders, and in the case of Sjögren's syndrome directly in saliva, requiring about a minute per assay. We also show the feasibility of coupling this method with a hand-held luminometer for portable testing. Our method offers the potential to quickly diagnose a multitude of autoimmune and infectious diseases in point-of-care settings.

Published
2017

10. PIEZO2 in sensory neurons and urothelial cells coordinates urination

Author

Marshall, Kara L., Saade, Dimah, Ghitani, Nima, Coombs, Adam M., Szczot, Marcin, Keller, Jason, and Ogata, Tracy

Subjects
Ion channels -- Physiological aspects, Urothelium -- Physiological aspects, Urination -- Observations, Sensory receptors -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Henry Miller stated that 'to relieve a full bladder is one of the great human joys'. Urination is critically important in health and ailments of the lower urinary tract cause high pathological burden. Although there have been advances in understanding the central circuitry in the brain that facilitates urination.sup.1-3, there is a lack of in-depth mechanistic insight into the process. In addition to central control, micturition reflexes that govern urination are all initiated by peripheral mechanical stimuli such as bladder stretch and urethral flow.sup.4. The mechanotransduction molecules and cell types that function as the primary stretch and pressure detectors in the urinary tract mostly remain unknown. Here we identify expression of the mechanosensitive ion channel PIEZO2 in lower urinary tract tissues, where it is required for low-threshold bladder-stretch sensing and urethral micturition reflexes. We show that PIEZO2 acts as a sensor in both the bladder urothelium and innervating sensory neurons. Humans and mice lacking functional PIEZO2 have impaired bladder control, and humans lacking functional PIEZO2 report deficient bladder-filling sensation. This study identifies PIEZO2 as a key mechanosensor in urinary function. These findings set the foundation for future work to identify the interactions between urothelial cells and sensory neurons that control urination. PIEZO2 is expressed in the bladder urothelium and sensory neurons innervating the lower urinary tract and is a key mechanosensor for the control of urination., Author(s): Kara L. Marshall [sup.1] , Dimah Saade [sup.2] , Nima Ghitani [sup.3] , Adam M. Coombs [sup.1] , Marcin Szczot [sup.3] , Jason Keller [sup.4] [sup.5] , Tracy Ogata [...]

Published
2020
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13. SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes

Author

van Hugte, Eline J H, primary, Lewerissa, Elly I, additional, Wu, Ka Man, additional, Scheefhals, Nicky, additional, Parodi, Giulia, additional, van Voorst, Torben W, additional, Puvogel, Sofia, additional, Kogo, Naoki, additional, Keller, Jason M, additional, Frega, Monica, additional, Schubert, Dirk, additional, Schelhaas, Helenius J, additional, Verhoeven, Judith, additional, Majoie, Marian, additional, van Bokhoven, Hans, additional, and Nadif Kasri, Nael, additional

Published
2023
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15. Pain control through selective chemo-axotomy of centrally projecting [TRPV1.sup.+] sensory neurons

Author

Sapio, Matthew R., Neubert, John K., LaPaglia, Danielle M., Maric, Dragan, Keller, Jason M., Raithel, Stephen J., Rohrs, Eric L., Anderson, Ethan M., Butman, John A., Caudle, Robert M., Brown, Dorothy C., Heiss, John D., Mannes, Andrew J., and Iadarola, Michael J.

Subjects
Nociception -- Research, Medical research, Alkaloids -- Health aspects -- Physiological aspects, Pain management -- Research, Ion channels -- Physiological aspects -- Health aspects, Somatosensory system -- Research, Health care industry
Abstract

Agonists of the vanilloid receptor transient vanilloid potential 1 (TRPV1) are emerging as highly efficacious nonopioid analgesics in preclinical studies. These drugs selectively lesion [TRPV1.sup.+] primary sensory afferents, which are responsible for the transmission of many noxious stimulus modalities. Resiniferatoxin (RTX) is a very potent and selective TRPV1 agonist and is a promising candidate for treating many types of pain. Recent work establishing intrathecal application of RTX for the treatment of pain resulting from advanced cancer has demonstrated profound analgesia in client-owned dogs with osteosarcoma. The present study uses transcriptomics and histochemistry to examine the molecular mechanism of RTX action in rats, in clinical canine subjects, and in 1 human subject with advanced cancer treated for pain using intrathecal RTX. In all 3 species, we observe a strong analgesic action, yet this was accompanied by limited transcriptional alterations at the level of the dorsal root ganglion. Functional and neuroanatomical studies demonstrated that intrathecal RTX largely spares susceptible neuronal perikarya, which remain active peripherally but unable to transmit signals to the spinal cord. The results demonstrate that central chemo-axotomy of the [TRPV1.sup.+] afferents underlies RTX analgesia and refine the neurobiology underlying effective clinical use of TRPV1 agonists for pain control., Introduction Severe chronic pain remains a medically intractable problem with life-altering consequences. While most chronic pain is currently treated with any number of drugs, including opioids, NSAIDs, and calcium channel [...]

Published
2018
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17. Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling

Author

Frega, Monica, Linda, Katrin, Keller, Jason M., Gümüş-Akay, Güvem, Mossink, Britt, van Rhijn, Jon-Ruben, Negwer, Moritz, Klein Gunnewiek, Teun, Foreman, Katharina, Kompier, Nine, Schoenmaker, Chantal, van den Akker, Willem, van der Werf, Ilse, Oudakker, Astrid, Zhou, Huiqing, Kleefstra, Tjitske, Schubert, Dirk, van Bokhoven, Hans, and Nadif Kasri, Nael

Published
2019
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20. Brainstem control of voluntary urination

Author

Keller, Jason Allen

Subjects
Neurosciences, Barrington, bladder, micturition, sphincter, urethra, urination
Abstract

Scent marking behavior in male mice can simultaneously address two important gaps in neuroscience: (1) the need for a simple and ethologically relevant output to make sense of the neural activity driving it, and (2) the need for better models of voluntary urination to take us beyond a coarse understanding of prevalent medical issues. Uncontrolled urination, or incontinence, is a common problem that stems from disruption at the two main muscles responsible, the bladder wall and external urethral sphincter (EUS). Lesion studies have shown that these muscles switch from urine storage to release via control from a small region in the brainstem known as Barrington’s nucleus (Bar). Although we know some cellular details of bladder control, specific neurons that relax the EUS and ultimately enable urine flow are unknown, partly because this is a voluntary, striated muscle, and adequate animal models of voluntary urination do not exist. Here we establish a scent marking assay in which male mice rapidly urinate when presented with female odor. This allows measurement and manipulation of neural activity in Bar while quantifying voluntary urination, and led us to identify a small subset of novel Bar neurons that control the EUS. These excitatory neurons express estrogen receptor 1 (BarESR1), project to sphincter-relaxing interneurons in the spinal cord, and have increased activity during natural urination. Optogenetic stimulation of BarESR1 neurons rapidly initiates sphincter bursting and efficient voiding in anesthetized and behaving animals. Conversely, optogenetic and chemogenetic inhibition reveals their necessity in motivated urination behavior. The identification of these cells provides an expanded model for the control of voluntary urination and its dysfunction, as well as a tractable anchor from which to study upstream control. Because scent marking behavior is regulated by age, sex, competing interests, and learning, this paradigm provides a powerful avenue for future studies examining more general mechanisms of behavioral control in mammals.

Published
2018

23. Evaluating alternative ebullition models for predicting peatland methane emission and its pathways via data–model fusion

Author

Ma, Shuang; https://orcid.org/0000-0002-6494-724X, Jiang, Lifen, Wilson, Rachel M, Chanton, Jeff P, Bridgham, Scott, Niu, Shuli, Iversen, Colleen M, Malhotra, Avni; https://orcid.org/0000-0002-7850-6402, Jiang, Jiang, Lu, Xingjie; https://orcid.org/0000-0003-3732-1978, Huang, Yuanyuan; https://orcid.org/0000-0003-4202-8071, Keller, Jason, Xu, Xiaofeng; https://orcid.org/0000-0002-6553-6514, Ricciuto, Daniel M; https://orcid.org/0000-0002-3668-3021, Hanson, Paul J; https://orcid.org/0000-0001-7293-3561, Luo, Yiqi, Ma, Shuang; https://orcid.org/0000-0002-6494-724X, Jiang, Lifen, Wilson, Rachel M, Chanton, Jeff P, Bridgham, Scott, Niu, Shuli, Iversen, Colleen M, Malhotra, Avni; https://orcid.org/0000-0002-7850-6402, Jiang, Jiang, Lu, Xingjie; https://orcid.org/0000-0003-3732-1978, Huang, Yuanyuan; https://orcid.org/0000-0003-4202-8071, Keller, Jason, Xu, Xiaofeng; https://orcid.org/0000-0002-6553-6514, Ricciuto, Daniel M; https://orcid.org/0000-0002-3668-3021, Hanson, Paul J; https://orcid.org/0000-0001-7293-3561, and Luo, Yiqi

Abstract

Understanding the dynamics of peatland methane (CH4) emissions and quantifying sources of uncertainty in estimating peatland CH4 emissions are critical for mitigating climate change. The relative contributions of CH4 emission pathways through ebullition, plant-mediated transport, and diffusion, together with their different transport rates and vulnerability to oxidation, determine the quantity of CH4 to be oxidized before leaving the soil. Notwithstanding their importance, the relative contributions of the emission pathways are highly uncertain. In particular, the ebullition process is more uncertain and can lead to large uncertainties in modeled CH4 emissions. To improve model simulations of CH4 emission and its pathways, we evaluated two model structures: (1) the ebullition bubble growth volume threshold approach (EBG) and (2) the modified ebullition concentration threshold approach (ECT) using CH4 flux and concentration data collected in a peatland in northern Minnesota, USA. When model parameters were constrained using observed CH4 fluxes, the CH4 emissions simulated by the EBG approach (RMSE = 0.53) had a better agreement with observations than the ECT approach (RMSE = 0.61). Further, the EBG approach simulated a smaller contribution from ebullition but more frequent ebullition events than the ECT approach. The EBG approach yielded greatly improved simulations of pore water CH4 concentrations, especially in the deep soil layers, compared to the ECT approach. When constraining the EBG model with both CH4 flux and concentration data in model–data fusion, uncertainty of the modeled CH4 concentration profiles was reduced by 78 % to 86 % in comparison to constraints based on CH4 flux data alone. The improved model capability was attributed to the well-constrained parameters regulating the CH4 production and emission pathways. Our results suggest that the EBG modeling approach better characterizes CH4 emission and underlying mechanisms. Moreover, to achieve the best

Published
2022

24. Soil organic carbon and nitrogen storage in two southern California salt marshes: the role of pre-restoration vegetation

Author

Keller, Jason K., Anthony, Tyler, Clark, Dustin, Gabriel, Kristin, Gamalath, Dewmini, Kabala, Ryan, King, Julie, Medina, Ladyssara, and Nguyen, Monica

Subjects
International Business Machines Corp., Soils -- Carbon content, Ecosystems, Tidal marshes, Computer industry -- International economic relations, Microcomputer industry, Computer industry, Science and technology
Abstract

Abstract.--Soil organic carbon and nitrogen storage represent important ecosystem services provided by salt marshes. To test the importance of vegetation on soil properties, we measured organic carbon, total nitrogen, and [...]

Published
2015

26. Evaluating alternative ebullition models for predicting peatland methane emission and its pathways via data–model fusion

Author

Ma, Shuang, primary, Jiang, Lifen, additional, Wilson, Rachel M., additional, Chanton, Jeff P., additional, Bridgham, Scott, additional, Niu, Shuli, additional, Iversen, Colleen M., additional, Malhotra, Avni, additional, Jiang, Jiang, additional, Lu, Xingjie, additional, Huang, Yuanyuan, additional, Keller, Jason, additional, Xu, Xiaofeng, additional, Ricciuto, Daniel M., additional, Hanson, Paul J., additional, and Luo, Yiqi, additional

Published
2022
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28. Evaluating alternative ebullition models for predicting peatland methane emission and its pathways via data–model fusion

Author

Ma, Shuang, Jiang, Lifen, Wilson, Rachel M, Chanton, Jeff P, Bridgham, Scott, Niu, Shuli, Iversen, Colleen M, Malhotra, Avni, Jiang, Jiang, Lu, Xingjie, Huang, Yuanyuan, Keller, Jason, Xu, Xiaofeng, Ricciuto, Daniel M, Hanson, Paul J, Luo, Yiqi, University of Zurich, and Luo, Yiqi

Subjects
10122 Institute of Geography, 1105 Ecology, Evolution, Behavior and Systematics, Surface Processes, Ecology, Behavior and Systematics, Evolution, 1904 Earth-Surface Processes, wetland methane, data-model fusion, emission pathways, belowground CH4 concentration profile, CH4 emission, climate change, Earth, 910 Geography & travel, Ecology, Evolution, Behavior and Systematics, Earth-Surface Processes
Abstract

Understanding the dynamics of peatland methane (CH4) emissions and quantifying sources of uncertainty in estimating peatland CH4 emissions are critical for mitigating climate change. The relative contributions of CH4 emission pathways through ebullition, plant-mediated transport, and diffusion, together with their different transport rates and vulnerability to oxidation, determine the quantity of CH4 to be oxidized before leaving the soil. Notwithstanding their importance, the relative contributions of the emission pathways are highly uncertain. In particular, the ebullition process is more uncertain and can lead to large uncertainties in modeled CH4 emissions. To improve model simulations of CH4 emission and its pathways, we evaluated two model structures: (1) the ebullition bubble growth volume threshold approach (EBG) and (2) the modified ebullition concentration threshold approach (ECT) using CH4 flux and concentration data collected in a peatland in northern Minnesota, USA. When model parameters were constrained using observed CH4 fluxes, the CH4 emissions simulated by the EBG approach (RMSE = 0.53) had a better agreement with observations than the ECT approach (RMSE = 0.61). Further, the EBG approach simulated a smaller contribution from ebullition but more frequent ebullition events than the ECT approach. The EBG approach yielded greatly improved simulations of pore water CH4 concentrations, especially in the deep soil layers, compared to the ECT approach. When constraining the EBG model with both CH4 flux and concentration data in model–data fusion, uncertainty of the modeled CH4 concentration profiles was reduced by 78 % to 86 % in comparison to constraints based on CH4 flux data alone. The improved model capability was attributed to the well-constrained parameters regulating the CH4 production and emission pathways. Our results suggest that the EBG modeling approach better characterizes CH4 emission and underlying mechanisms. Moreover, to achieve the best model results both CH4 flux and concentration data are required to constrain model parameterization.

Published
2022
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30. The Authors Reply

Author

Weltzin, Jake F., Belote, R. Travis, Williams, Leigh T., Keller, Jason K., and Engel, E. Cayenne

Published
2007

35. Soil organic carbon storage in restored salt marshes in Huntington Beach, California

Author

Keller, Jason K., Takagi, Kimberly K., Brown, Morgan E., Stump, Kellie N., Takahashi, Chelsea G., Joo, Woojin, Au, Kimberlee L., Calhoun, Caitlin C., Chundu, Rajesh K., Hokutan, Kanani, Mosolf, Jessica M., and Roy, Kylle

Subjects
Huntington Beach, California -- Environmental aspects, Wetland conservation -- Environmental aspects, Methane -- Environmental aspects -- Measurement, Soils -- Carbon content, Tidal marshes -- Environmental aspects, Carbon sequestration -- Methods -- Research, Science and technology
Abstract

Abstract.--There is a growing interest in managing wetland restoration and conservation projects to maximize carbon sequestration. We measured soil organic carbon storage and methane flux from two southern California salt [...]

Published
2012

37. m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity

Author

Klein Gunnewiek, Teun M., primary, Van Hugte, Eline J.H., additional, Frega, Monica, additional, Guardia, Gemma Solé, additional, Foreman, Katharina, additional, Panneman, Daan, additional, Mossink, Britt, additional, Linda, Katrin, additional, Keller, Jason M., additional, Schubert, Dirk, additional, Cassiman, David, additional, Rodenburg, Richard, additional, Vidal Folch, Noemi, additional, Oglesbee, Devin, additional, Perales-Clemente, Ester, additional, Nelson, Timothy J., additional, Morava, Eva, additional, Nadif Kasri, Nael, additional, and Kozicz, Tamas, additional

Published
2020
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38. Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype

Author

Frega, Monica, primary, Selten, Martijn, additional, Mossink, Britt, additional, Keller, Jason M., additional, Linda, Katrin, additional, Moerschen, Rebecca, additional, Qu, Jieqiong, additional, Koerner, Pierre, additional, Jansen, Sophie, additional, Oudakker, Astrid, additional, Kleefstra, Tjitske, additional, van Bokhoven, Hans, additional, Zhou, Huiqing, additional, Schubert, Dirk, additional, and Nadif Kasri, Nael, additional

Published
2020
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39. Evaluating alternative ebullition models for predicting peatland methane emission and its pathways via data-model fusion.

Author

Ma, Shuang, Jiang, Lifen, Wilson, Rachel M., Chanton, Jeff P., Bridgham, Scott, Niu, Shuli, Iversen, Colleen M., Malhotra, Avni, Jiang, Jiang, Lu, Xingjie, Huang, Yuanyuan, Keller, Jason, Xu, Xiaofeng, Ricciuto, Daniel M., Hanson, Paul J., and Luo, Yiqi

Subjects
EBULLITION, METHANE, PORE water, MULTISENSOR data fusion, CLIMATE change, NATURAL gas vehicles
Abstract

Understanding the dynamics of peatland methane (CH4) emissions and quantifying sources of uncertainty in estimating peatland CH4 emissions are critical for mitigating climate change. The relative contributions of CH4 emission pathways through ebullition, plant-mediated transport, and diffusion together with their different transport rates and vulnerability to oxidation determine the quantity of CH4 to be oxidized before leaving the soil. Notwithstanding their importance, the relative contributions of the emission pathways have not been well characterized by experiments or modeling approaches. In particular, the ebullition process is more uncertain and can lead to large uncertainties in modeled CH4 emissions. To improve model simulations of CH4 emission and its pathways, we evaluated two model structures: 1) the Ebullition Bubble Growth volume threshold approach (EBG) and 2) the modified Ebullition Concentration Threshold approach (ECT) using CH4 flux and concentration data collected in a peatland in northern Minnesota, USA. When model parameters were constrained using observed CH4 fluxes, the CH4 emissions simulated by the EBG approach (RMSE = 0.53) had a better agreement with observations than the ECT approach (RMSE = 0.61). Further, the EBG approach simulated a smaller contribution from ebullition but more frequent ebullition events than the ECT approach. The EBG approach yielded greatly improved simulations of pore water CH4 concentrations, especially in the deep soil layers, compared to the ECT approach. When constraining the EBG model with both CH4 flux and concentration data in model-data fusion, uncertainty of the modeled CH4 concentration profiles was reduced by 78 to 86 % in comparison to constraints based on CH4 flux data alone. The improved model capability was attributed to the well-constrained parameters regulating the CH4 production and emission pathways. Our results suggest that the EBG modeling approach better characterizes CH4 emission and underlying mechanisms. Moreover, to achieve the best model results both CH4 flux and concentration data are required to constrain model parameterization. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Positive allosteric modulation of TRPV1 as a novel analgesic mechanism

Author

Lebovitz Evan E, Keller Jason M, Kominsky Hal, Kaszas Krisztian, Maric Dragan, and Iadarola Michael J

Subjects
TRPV1, Pain, Capsaicin, Vanilloid, Nociception, Resiniferatoxin, ATF3, Dorsal root ganglion, MRS1477, Adelta fiber, Pathology, RB1-214
Abstract

Abstract Background The prevalence of long-term opiate use in treating chronic non-cancer pain is increasing, and prescription opioid abuse and dependence are a major public health concern. To explore alternatives to opioid-based analgesia, the present study investigates a novel allosteric pharmacological approach operating through the cation channel TRPV1. This channel is highly expressed in subpopulations of primary afferent unmyelinated C- and lightly-myelinated Aδ-fibers that detect low and high rates of noxious heating, respectively, and it is also activated by vanilloid agonists and low pH. Sufficient doses of exogenous vanilloid agonists, such as capsaicin or resiniferatoxin, can inactivate/deactivate primary afferent endings due to calcium overload, and we hypothesized that positive allosteric modulation of agonist-activated TRPV1 could produce a selective, temporary inactivation of nociceptive nerve terminals in vivo. We previously identified MRS1477, a 1,4-dihydropyridine that potentiates vanilloid and pH activation of TRPV1 in vitro, but displays no detectable intrinsic agonist activity of its own. To study the in vivo effects of MRS1477, we injected the hind paws of rats with a non-deactivating dose of capsaicin, MRS1477, or the combination. An infrared diode laser was used to stimulate TRPV1-expressing nerve terminals and the latency and intensity of paw withdrawal responses were recorded. qRT-PCR and immunohistochemistry were performed on dorsal root ganglia to examine changes in gene expression and the cellular specificity of such changes following treatment. Results Withdrawal responses of the capsaicin-only or MRS1477-only treated paws were not significantly different from the untreated, contralateral paws. However, rats treated with the combination of capsaicin and MRS1477 exhibited increased withdrawal latency and decreased response intensity consistent with agonist potentiation and inactivation or lesion of TRPV1-containing nerve terminals. The loss of nerve endings was manifested by an increase in levels of axotomy markers assessed by qRT-PCR and colocalization of ATF3 in TRPV1+ cells visualized via immunohistochemistry. Conclusions The present observations suggest a novel, non-narcotic, selective, long-lasting TRPV1-based approach for analgesia that may be effective in acute, persistent, or chronic pain disorders.

Published
2012
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41. Resveratrol inhibits Cdk5 activity through regulation of p35 expression

Author

Kulkarni Ashok B, Iadarola Michael J, Keller Jason, Terse Anita, and Utreras Elias

Subjects
Cdk5, resveratrol, TNF-α, pain, Egr-1, ERK1/2, analgesic, Pathology, RB1-214
Abstract

Abstract Background We have previously reported that cyclin-dependent kinase 5 (Cdk5) participates in the regulation of nociceptive signaling. Through activation of the ERK1/2 pathway, Tumor Necrosis Factor-α (TNF-α) induces expression of Egr-1. This results in the sustained and robust expression of p35, a coactivator of Cdk5, in PC12 cells, thereby increasing Cdk5 kinase activity. The aim of our present study was to test whether resveratrol, a polyphenolic compound with known analgesic activity, can regulate Cdk5/p35 activity. Results Here we used a cell-based assay in which a p35 promoter-luciferase construct was stably transfected in PC12 cells. Our studies demonstrate that resveratrol inhibits p35 promoter activity and also blocks the TNF-α mediated increase in Cdk5 activity in PC12 cells. Resveratrol also inhibits p35 expression and blocks the TNF-α mediated increase in Cdk5 activity in DRG neurons. In the presence of resveratrol, the MEK inhibitor decreased p35 promoter activity, whereas the inhibitors of p38 MAPK, JNK and NF-κB increased p35 promoter activity, indicating that these pathways regulate p35 expression differently. The TNF-α-mediated increase in Egr-1 expression was decreased by resveratrol treatment with a concomitant reduction in p35 expression and protein levels, resulting in reduced Cdk5 kinase activity. Conclusions We demonstrate here that resveratrol regulates p35 promoter activity in PC12 cells and DRG neurons. Most importantly, resveratrol blocks the TNF-α-mediated increase in p35 promoter activity, thereby reducing p35 expression and subsequent Cdk5 kinase activity. This new molecular mechanism adds to the known analgesic effects of resveratrol and confirms the need for identifying new analgesics based on their ability to inhibit Cdk5 activity for effective treatment of pain.

Published
2011
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42. Ablation of rat TRPV1-expressing Adelta/C-fibers with resiniferatoxin: analysis of withdrawal behaviors, recovery of function and molecular correlates

Author

Haspel Gal, Madian Nicholas, Navarro Julia, Scholl Lindsey, Lopez Matthew, Keller Jason M, Bates Brian D, Mitchell Kendall, Nemenov Michael I, and Iadarola Michael J

Subjects
Pathology, RB1-214
Abstract

Abstract Background Ablation of TRPV1-expressing nociceptive fibers with the potent capsaicin analog resiniferatoxin (RTX) results in long lasting pain relief. RTX is particularly adaptable to focal application, and the induced chemical axonopathy leads to analgesia with a duration that is influenced by dose, route of administration, and the rate of fiber regeneration. TRPV1 is expressed in a subpopulation of unmyelinated C- and lightly myelinated Adelta fibers that detect changes in skin temperature at low and high rates of noxious heating, respectively. Here we investigate fiber-type specific behaviors, their time course of recovery and molecular correlates of axon damage and nociception using infrared laser stimuli following an RTX-induced peripheral axonopathy. Results RTX was injected into rat hind paws (mid-plantar) to produce thermal hypoalgesia. An infrared diode laser was used to stimulate Adelta fibers in the paw with a small-diameter (1.6 mm), high-energy, 100 msec pulse, or C-fibers with a wide-diameter (5 mm), long-duration, low-energy pulse. We monitored behavioral responses to indicate loss and regeneration of fibers. At the site of injection, responses to C-fiber stimuli were significantly attenuated for two weeks after 5 or 50 ng RTX. Responses to Adelta stimuli were significantly attenuated for two weeks at the highest intensity stimulus, and for 5 weeks to a less intense Adelta stimulus. Stimulation on the toe, a site distal to the injection, showed significant attenuation of Adelta responses for 7- 8 weeks after 5 ng, or 9-10 weeks after 50 ng RTX. In contrast, responses to C-fiber stimuli exhibited basically normal responses at 5 weeks after RTX. During the period of fiber loss and recovery, molecular markers for nerve regeneration (ATF3 and galanin) are upregulated in the dorsal root ganglia (DRG) when behavior is maximally attenuated, but markers of nociceptive activity (c-Fos in spinal cord and MCP-1 in DRG), although induced immediately after RTX treatment, returned to normal. Conclusion Behavioral recovery following peripheral RTX treatment is linked to regeneration of TRPV1-expressing Adelta and C-fibers and sustained expression of molecular markers. Infrared laser stimulation is a potentially valuable tool for evaluating the behavioral role of Adelta fibers in pain and pain control.

Published
2010
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43. Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin

Author

Perez Federico M, Keller Jason, Mannes Andrew J, Caudle Robert M, Suckow Shelby K, and Neubert John K

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Several investigators have coupled toxins to neuropeptides for the purpose of lesioning specific neurons in the central nervous system. By producing deficits in function these toxin conjugates have yielded valuable information about the role of these cells. In an effort to specifically stimulate cells rather than kill them we have conjugated the neuropeptide substance P to the catalytic subunit of cholera toxin (SP-CTA). This conjugate should be taken up selectively by neurokinin receptor expressing neurons resulting in enhanced adenylate cyclase activity and neuronal firing. Results The conjugate SP-CTA stimulates adenylate cyclase in cultured cells that are transfected with either the NK1 or NK2 receptor, but not the NK3 receptor. We further demonstrate that intrathecal injection of SP-CTA in rats induces the phosphorylation of the transcription factor cyclic AMP response element binding protein (CREB) and also enhances the expression of the immediate early gene c-Fos. Behaviorally, low doses of SP-CTA (1 μg) injected intrathecally produce thermal hyperalgesia. At higher doses (10 μg) peripheral sensitivity is suppressed suggesting that descending inhibitory pathways may be activated by the SP-CTA induced sensitization of spinal cord neurons. Conclusion The finding that stimulation of adenylate cyclase in neurokinin receptor expressing neurons in the spinal cord produces thermal hyperalgesia is consistent with the known actions of these neurons. These data demonstrate that cholera toxin can be targeted to specific cell types by coupling the catalytic subunit to a peptide agonist for a g-protein coupled receptor. Furthermore, these results demonstrate that SP-CTA can be used as a tool to study sensitization of central neurons in vivo in the absence of an injury.

Published
2007
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46. Hydrogenation of organic matter as a terminal electron sink sustains high CO2 : CH4 production ratios during anaerobic decomposition

Author

Wilson, Rachel M., Tfaily, Malak M., Rich, Virginia I., Keller, Jason K., Bridgham, Scott D., Medvedeff Zalman, Cassandra, Meredith, Laura, Hanson, Paul J., Hines, Mark, Pfeifer-Meister, Laurel, Saleska, Scott R., Crill, Patrick, Cooper, William T., Chanton, Jeff P., Kostka, Joel E., Wilson, Rachel M., Tfaily, Malak M., Rich, Virginia I., Keller, Jason K., Bridgham, Scott D., Medvedeff Zalman, Cassandra, Meredith, Laura, Hanson, Paul J., Hines, Mark, Pfeifer-Meister, Laurel, Saleska, Scott R., Crill, Patrick, Cooper, William T., Chanton, Jeff P., and Kostka, Joel E.

Abstract

Once inorganic electron acceptors are depleted, organic matter in anoxic environments decomposes by hydrolysis, fermentation, and methanogenesis, requiring syntrophic interactions between microorganisms to achieve energetic favorability. In this classic anaerobic food chain, methanogenesis represents the terminal electron accepting (TEA) process, ultimately producing equimolar CO2 and CH4 for each molecule of organic matter degraded. However, CO2:CH4 production in Sphagnum-derived, mineral-poor, cellulosic peat often substantially exceeds this 1:1 ratio, even in the absence of measureable inorganic TEAs. Since the oxidation state of C in both cellulose-derived organic matter and acetate is 0, and CO2 has an oxidation state of +4, if CH4 (oxidation state -4) is not produced in equal ratio, then some other compound(s) must balance CO2 production by receiving 4 electrons. Here we present evidence for ubiquitous hydrogenation of diverse unsaturated compounds that appear to serve as organic TEAs in peat, thereby providing the necessary electron balance to sustain CO2:CH4 > 1. While organic electron acceptors have previously been proposed to drive microbial respiration of organic matter through the reversible reduction of quinone moieties, the hydrogenation mechanism that we propose, by contrast, reduces CAC double bonds in organic matter thereby serving as (1) a terminal electron sink, (2) a mechanism for degrading complex unsaturated organic molecules, (3) a potential mechanism to regenerate electron-accepting quinones, and, in some cases, (4) a means to alleviate the toxicity of unsaturated aromatic acids. This mechanism for CO2 generation without concomitant CH4 production has the potential to regulate the global warming potential of peatlands by elevating CO2:CH4 production ratios.

Published
2017
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48. Evidence for the direct decay of the 125 GeV Higgs boson to fermions

Author

Chatrchyan, Serguei, Khachatryan, Vardan, Fruehwirth, Rudolf, Yazgan, Efe, Beirão Da Cruz E Silva, Cristóvão, Faccioli, Pietro, Ferreira Parracho, Pedro Guilherme, Gallinaro, Michele, Nguyen, Federico, Rodrigues Antunes, Joao, Seixas, Joao, Varela, Joao, Vischia, Pietro, Golutvin, Igor, Zaganidis, Nicolas, Gorbunov, Ilya, Karjavin, Vladimir, Konoplyanikov, Viktor, Korenkov, Vladimir, Kozlov, Guennady, Lanev, Alexander, Malakhov, Alexander, Matveev, Viktor, Moisenz, Petr, Palichik, Vladimir, Basegmez, Suzan, Perelygin, Victor, Savina, Maria, Shmatov, Sergey, Shulha, Siarhei, Skatchkov, Nikolai, Smirnov, Vitaly, Zarubin, Anatoli, Golovtsov, Victor, Ivanov, Yury, Kim, Victor, Beluffi, Camille, Levchenko, Petr, Murzin, Victor, Oreshkin, Vadim, Smirnov, Igor, Sulimov, Valentin, Uvarov, Lev, Vavilov, Sergey, Vorobyev, Alexey, Vorobyev, Andrey, Andreev, Yuri, Bruno, Giacomo, Dermenev, Alexander, Gninenko, Sergei, Golubev, Nikolai, Kirsanov, Mikhail, Krasnikov, Nikolai, Pashenkov, Anatoli, Tlisov, Danila, Toropin, Alexander, Epshteyn, Vladimir, Gavrilov, Vladimir, Castello, Roberto, Lychkovskaya, Natalia, Popov, Vladimir, Safronov, Grigory, Semenov, Sergey, Spiridonov, Alexander, Stolin, Viatcheslav, Vlasov, Evgueni, Zhokin, Alexander, Andreev, Vladimir, Azarkin, Maksim, Caudron, Adrien, Dremin, Igor, Kirakosyan, Martin, Leonidov, Andrey, Mesyats, Gennady, Rusakov, Sergey V, Vinogradov, Alexey, Belyaev, Andrey, Boos, Edouard, Dubinin, Mikhail, Dudko, Lev, Ceard, Ludivine, Ershov, Alexander, Gribushin, Andrey, Klyukhin, Vyacheslav, Kodolova, Olga, Lokhtin, Igor, Obraztsov, Stepan, Perfilov, Maxim, Petrushanko, Sergey, Savrin, Viktor, Azhgirey, Igor, Da Silveira, Gustavo Gil, Bayshev, Igor, Bitioukov, Sergei, Kachanov, Vassili, Kalinin, Alexey, Konstantinov, Dmitri, Krychkine, Victor, Petrov, Vladimir, Ryutin, Roman, Sobol, Andrei, Tourtchanovitch, Leonid, Delaere, Christophe, Troshin, Sergey, Tyurin, Nikolay, Uzunian, Andrey, Volkov, Alexey, Adzic, Petar, Djordjevic, Milos, Ekmedzic, Marko, Milosevic, Jovan, Aguilar-Benitez, Manuel, Alcaraz Maestre, Juan, Ghete, Vasile Mihai, Du Pree, Tristan, Battilana, Carlo, Calvo, Enrique, Cerrada, Marcos, Chamizo Llatas, Maria, Colino, Nicanor, De La Cruz, Begona, Delgado Peris, Antonio, Domínguez Vázquez, Daniel, Fernandez Bedoya, Cristina, Fernández Ramos, Juan Pablo, Favart, Denis, Ferrando, Antonio, Flix, Jose, Fouz, Maria Cruz, Garcia-Abia, Pablo, Gonzalez Lopez, Oscar, Goy Lopez, Silvia, Hernandez, Jose M, Josa, Maria Isabel, Merino, Gonzalo, Navarro De Martino, Eduardo, Forthomme, Laurent, Pérez Calero Yzquierdo, Antonio María, Puerta Pelayo, Jesus, Quintario Olmeda, Adrián, Redondo, Ignacio, Romero, Luciano, Soares, Mara Senghi, Willmott, Carlos, Albajar, Carmen, de Trocóniz, Jorge F, Missiroli, Marino, Giammanco, Andrea, Brun, Hugues, Cuevas, Javier, Fernandez Menendez, Javier, Folgueras, Santiago, Gonzalez Caballero, Isidro, Lloret Iglesias, Lara, Brochero Cifuentes, Javier Andres, Cabrillo, Iban Jose, Calderon, Alicia, Duarte Campderros, Jordi, Hollar, Jonathan, Fernandez, Marcos, Gomez, Gervasio, Gonzalez Sanchez, Javier, Graziano, Alberto, Lopez Virto, Amparo, Marco, Jesus, Marco, Rafael, Martinez Rivero, Celso, Matorras, Francisco, Munoz Sanchez, Francisca Javiela, Jez, Pavel, Piedra Gomez, Jonatan, Rodrigo, Teresa, Rodríguez-Marrero, Ana Yaiza, Ruiz-Jimeno, Alberto, Scodellaro, Luca, Vila, Ivan, Vilar Cortabitarte, Rocio, Abbaneo, Duccio, Auffray, Etiennette, Auzinger, Georg, Komm, Matthias, Bachtis, Michail, Baillon, Paul, Ball, Austin, Barney, David, Benaglia, Andrea, Bendavid, Joshua, Benhabib, Lamia, Benitez, Jose F, Bernet, Colin, Bianchi, Giovanni, Lemaitre, Vincent, Bloch, Philippe, Bocci, Andrea, Bonato, Alessio, Bondu, Olivier, Botta, Cristina, Breuker, Horst, Camporesi, Tiziano, Cerminara, Gianluca, Christiansen, Tim, Coarasa Perez, Jose Antonio, Liao, Junhui, Colafranceschi, Stefano, D'Alfonso, Mariarosaria, D'Enterria, David, Dabrowski, Anne, David Tinoco Mendes, Andre, De Guio, Federico, De Roeck, Albert, De Visscher, Simon, Dobson, Marc, Dupont-Sagorin, Niels, Militaru, Otilia, Elliott-Peisert, Anna, Eugster, Jürg, Franzoni, Giovanni, Funk, Wolfgang, Giffels, Manuel, Gigi, Dominique, Gill, Karl, Girone, Maria, Giunta, Marina, Glege, Frank, Hartl, Christian, Nuttens, Claude, Gomez-Reino Garrido, Robert, Gowdy, Stephen, Guida, Roberto, Hammer, Josef, Hansen, Magnus, Harris, Philip, Hegeman, Jeroen, Innocente, Vincenzo, Janot, Patrick, Karavakis, Edward, Pagano, Davide, Kousouris, Konstantinos, Krajczar, Krisztian, Lecoq, Paul, Lourenco, Carlos, Magini, Nicolo, Malgeri, Luca, Mannelli, Marcello, Masetti, Lorenzo, Meijers, Frans, Mersi, Stefano, Pin, Arnaud, Meschi, Emilio, Moortgat, Filip, Mulders, Martijn, Musella, Pasquale, Orsini, Luciano, Palencia Cortezon, Enrique, Pape, Luc, Perez, Emmanuelle, Perrozzi, Luca, Petrilli, Achille, Piotrzkowski, Krzysztof, Petrucciani, Giovanni, Pfeiffer, Andreas, Pierini, Maurizio, Pimiä, Martti, Piparo, Danilo, Plagge, Michael, Racz, Attila, Reece, William, Rolandi, Gigi, Rovere, Marco, Popov, Andrey, Sakulin, Hannes, Santanastasio, Francesco, Schäfer, Christoph, Schwick, Christoph, Sekmen, Sezen, Sharma, Archana, Siegrist, Patrice, Silva, Pedro, Simon, Michal, Sphicas, Paraskevas, Quertenmont, Loic, Steggemann, Jan, Stieger, Benjamin, Stoye, Markus, Treille, Daniel, Tsirou, Andromachi, Veres, Gabor Istvan, Vlimant, Jean-Roch, Wöhri, Hermine Katharina, Zeuner, Wolfram Dietrich, Bertl, Willi, Selvaggi, Michele, Deiters, Konrad, Erdmann, Wolfram, Horisberger, Roland, Ingram, Quentin, Kaestli, Hans-Christian, König, Stefan, Kotlinski, Danek, Langenegger, Urs, Renker, Dieter, Rohe, Tilman, Vidal Marono, Miguel, Bachmair, Felix, Bäni, Lukas, Bianchini, Lorenzo, Bortignon, Pierluigi, Buchmann, Marco-Andrea, Casal, Bruno, Chanon, Nicolas, Deisher, Amanda, Dissertori, Günther, Dittmar, Michael, Vizan Garcia, Jesus Manuel, Donegà, Mauro, Dünser, Marc, Eller, Philipp, Grab, Christoph, Hits, Dmitry, Lustermann, Werner, Mangano, Boris, Marini, Andrea Carlo, Martinez Ruiz del Arbol, Pablo, Meister, Daniel, Beliy, Nikita, Mohr, Niklas, Nägeli, Christoph, Nef, Pascal, Nessi-Tedaldi, Francesca, Pandolfi, Francesco, Pauss, Felicitas, Peruzzi, Marco, Quittnat, Milena, Rebane, Liis, Ronga, Frederic Jean, Hörmann, Natascha, Caebergs, Thierry, Rossini, Marco, Starodumov, Andrei, Takahashi, Maiko, Theofilatos, Konstantinos, Wallny, Rainer, Weber, Hannsjoerg Artur, Amsler, Claude, Canelli, Maria Florencia, Chiochia, Vincenzo, De Cosa, Annapaola, Daubie, Evelyne, Hinzmann, Andreas, Hreus, Tomas, Ivova Rikova, Mirena, Kilminster, Benjamin, Millan Mejias, Barbara, Ngadiuba, Jennifer, Robmann, Peter, Snoek, Hella, Taroni, Silvia, Verzetti, Mauro, Hammad, Gregory Habib, Yang, Yong, Cardaci, Marco, Chen, Kuan-Hsin, Ferro, Cristina, Kuo, Chia-Ming, Li, Syue-Wei, Lin, Willis, Lu, Yun-Ju, Volpe, Roberta, Yu, Shin-Shan, Alves, Gilvan, Bartalini, Paolo, Chang, Paoti, Chang, You-Hao, Chang, Yu-Wei, Chao, Yuan, Chen, Kai-Feng, Chen, Po-Hsun, Dietz, Charles, Grundler, Ulysses, Hou, George Wei-Shu, Correa Martins Junior, Marcos, Hsiung, Yee, Kao, Kai-Yi, Lei, Yeong-Jyi, Liu, Yueh-Feng, Lu, Rong-Shyang, Majumder, Devdatta, Petrakou, Eleni, Shi, Xin, Shiu, Jing-Ge, Tzeng, Yeng-Ming, Dos Reis Martins, Thiago, Wang, Minzu, Wilken, Rachel, Asavapibhop, Burin, Suwonjandee, Narumon, Adiguzel, Aytul, Bakirci, Mustafa Numan, Cerci, Salim, Dozen, Candan, Dumanoglu, Isa, Eskut, Eda, Pol, Maria Elena, Girgis, Semiray, Gokbulut, Gul, Gurpinar, Emine, Hos, Ilknur, Kangal, Evrim Ersin, Kayis Topaksu, Aysel, Onengut, Gulsen, Ozdemir, Kadri, Ozturk, Sertac, Polatoz, Ayse, Henrique Gomes E Souza, Moacyr, Sogut, Kenan, Sunar Cerci, Deniz, Tali, Bayram, Topakli, Huseyin, Vergili, Mehmet, Akin, Ilina Vasileva, Aliev, Takhmasib, Bilin, Bugra, Bilmis, Selcuk, Deniz, Muhammed, Aldá Júnior, Walter Luiz, Gamsizkan, Halil, Guler, Ali Murat, Karapinar, Guler, Ocalan, Kadir, Ozpineci, Altug, Serin, Meltem, Sever, Ramazan, Surat, Ugur Emrah, Yalvac, Metin, Zeyrek, Mehmet, Carvalho, Wagner, Gülmez, Erhan, Isildak, Bora, Kaya, Mithat, Kaya, Ozlem, Ozkorucuklu, Suat, Bahtiyar, Hüseyin, Barlas, Esra, Cankocak, Kerem, Günaydin, Yusuf Oguzhan, Vardarli, Fuat Ilkehan, Hrubec, Josef, Chinellato, Jose, Yücel, Mete, Levchuk, Leonid, Sorokin, Pavel, Brooke, James John, Clement, Emyr, Cussans, David, Flacher, Henning, Frazier, Robert, Goldstein, Joel, Grimes, Mark, Custódio, Analu, Heath, Greg P, Heath, Helen F, Jacob, Jeson, Kreczko, Lukasz, Lucas, Chris, Meng, Zhaoxia, Newbold, Dave M, Paramesvaran, Sudarshan, Poll, Anthony, Senkin, Sergey, Da Costa, Eliza Melo, Smith, Vincent J, Williams, Thomas, Bell, Ken W, Belyaev, Alexander, Brew, Christopher, Brown, Robert M, Cockerill, David JA, Coughlan, John A, Harder, Kristian, Harper, Sam, De Jesus Damiao, Dilson, Ilic, Jelena, Olaiya, Emmanuel, Petyt, David, Shepherd-Themistocleous, Claire, Thea, Alessandro, Tomalin, Ian R, Womersley, William John, Worm, Steven, Baber, Mark, Bainbridge, Robert, De Oliveira Martins, Carley, Buchmuller, Oliver, Burton, Darren, Colling, David, Cripps, Nicholas, Cutajar, Michael, Dauncey, Paul, Davies, Gavin, Della Negra, Michel, Ferguson, William, Fulcher, Jonathan, Fonseca De Souza, Sandro, Futyan, David, Gilbert, Andrew, Guneratne Bryer, Arlo, Hall, Geoffrey, Hatherell, Zoe, Hays, Jonathan, Iles, Gregory, Jarvis, Martyn, Karapostoli, Georgia, Kenzie, Matthew, Malbouisson, Helena, Lane, Rebecca, Lucas, Robyn, Lyons, Louis, Magnan, Anne-Marie, Marrouche, Jad, Mathias, Bryn, Nandi, Robin, Nash, Jordan, Nikitenko, Alexander, Pela, Joao, Malek, Magdalena, Pesaresi, Mark, Petridis, Konstantinos, Pioppi, Michele, Raymond, David Mark, Rogerson, Samuel, Rose, Andrew, Seez, Christopher, Sharp, Peter, Sparrow, Alex, Tapper, Alexander, Matos Figueiredo, Diego, Vazquez Acosta, Monica, Virdee, Tejinder, Wakefield, Stuart, Wardle, Nicholas, Cole, Joanne, Hobson, Peter R, Khan, Akram, Kyberd, Paul, Leggat, Duncan, Leslie, Dawn, Mundim, Luiz, Martin, William, Reid, Ivan, Symonds, Philip, Teodorescu, Liliana, Turner, Mark, Dittmann, Jay, Hatakeyama, Kenichi, Kasmi, Azeddine, Liu, Hongxuan, Scarborough, Tara, Jeitler, Manfred, Nogima, Helio, Charaf, Otman, Cooper, Seth, Henderson, Conor, Rumerio, Paolo, Avetisyan, Aram, Bose, Tulika, Fantasia, Cory, Heister, Arno, Lawson, Philip, Lazic, Dragoslav, Prado Da Silva, Wanda Lucia, Richardson, Clint, Rohlf, James, Sperka, David, St John, Jason, Sulak, Lawrence, Alimena, Juliette, Bhattacharya, Saptaparna, Christopher, Grant, Cutts, David, Demiragli, Zeynep, Santaolalla, Javier, Ferapontov, Alexey, Garabedian, Alex, Heintz, Ulrich, Jabeen, Shabnam, Kukartsev, Gennadiy, Laird, Edward, Landsberg, Greg, Luk, Michael, Narain, Meenakshi, Segala, Michael, Santoro, Alberto, Sinthuprasith, Tutanon, Speer, Thomas, Swanson, Joshua, Breedon, Richard, Breto, Guillermo, Calderon De La Barca Sanchez, Manuel, Chauhan, Sushil, Chertok, Maxwell, Conway, John, Conway, Rylan, Sznajder, Andre, Cox, Peter Timothy, Erbacher, Robin, Gardner, Michael, Ko, Winston, Kopecky, Alexandra, Lander, Richard, Miceli, Tia, Mulhearn, Michael, Pellett, Dave, Pilot, Justin, Tonelli Manganote, Edmilson José, Ricci-Tam, Francesca, Rutherford, Britney, Searle, Matthew, Shalhout, Shalhout, Smith, John, Squires, Michael, Tripathi, Mani, Wilbur, Scott, Yohay, Rachel, Andreev, Valeri, Vilela Pereira, Antonio, Cline, David, Cousins, Robert, Erhan, Samim, Everaerts, Pieter, Farrell, Chris, Felcini, Marta, Hauser, Jay, Ignatenko, Mikhail, Jarvis, Chad, Rakness, Gregory, Bernardes, Cesar Augusto, Takasugi, Eric, Valuev, Vyacheslav, Weber, Matthias, Babb, John, Clare, Robert, Ellison, John Anthony, Gary, J William, Hanson, Gail, Heilman, Jesse, Jandir, Pawandeep, De Almeida Dias, Flavia, Lacroix, Florent, Liu, Hongliang, Long, Owen Rosser, Luthra, Arun, Malberti, Martina, Nguyen, Harold, Shrinivas, Amithabh, Sturdy, Jared, Sumowidagdo, Suharyo, Wimpenny, Stephen, Tomei, Thiago, Andrews, Warren, Branson, James G, Cerati, Giuseppe Benedetto, Cittolin, Sergio, D'Agnolo, Raffaele Tito, Evans, David, Holzner, André, Kelley, Ryan, Kovalskyi, Dmytro, Lebourgeois, Matthew, Kiesenhofer, Wolfgang, De Moraes Gregores, Eduardo, Letts, James, Macneill, Ian, Padhi, Sanjay, Palmer, Christopher, Pieri, Marco, Sani, Matteo, Sharma, Vivek, Simon, Sean, Sudano, Elizabeth, Tadel, Matevz, Mercadante, Pedro G, Tu, Yanjun, Vartak, Adish, Wasserbaech, Steven, Würthwein, Frank, Yagil, Avraham, Yoo, Jaehyeok, Barge, Derek, Bradmiller-Feld, John, Campagnari, Claudio, Danielson, Thomas, Novaes, Sergio F, Dishaw, Adam, Flowers, Kristen, Franco Sevilla, Manuel, Geffert, Paul, George, Christopher, Golf, Frank, Incandela, Joe, Justus, Christopher, Magaña Villalba, Ricardo, Mccoll, Nickolas, Padula, Sandra, Pavlunin, Viktor, Richman, Jeffrey, Rossin, Roberto, Stuart, David, To, Wing, West, Christopher, Apresyan, Artur, Bornheim, Adolf, Bunn, Julian, Chen, Yi, Genchev, Vladimir, Di Marco, Emanuele, Duarte, Javier, Kcira, Dorian, Mott, Alexander, Newman, Harvey B, Pena, Cristian, Rogan, Christopher, Spiropulu, Maria, Timciuc, Vladlen, Wilkinson, Richard, Iaydjiev, Plamen, Xie, Si, Zhu, Ren-Yuan, Azzolini, Virginia, Calamba, Aristotle, Carroll, Ryan, Ferguson, Thomas, Iiyama, Yutaro, Jang, Dong Wook, Paulini, Manfred, Russ, James, Marinov, Andrey, Vogel, Helmut, Vorobiev, Igor, Cumalat, John Perry, Drell, Brian Robert, Ford, William T, Gaz, Alessandro, Luiggi Lopez, Eduardo, Nauenberg, Uriel, Smith, James, Stenson, Kevin, Piperov, Stefan, Ulmer, Keith, Wagner, Stephen Robert, Alexander, James, Chatterjee, Avishek, Chu, Jennifer, Eggert, Nicholas, Gibbons, Lawrence Kent, Hopkins, Walter, Khukhunaishvili, Aleko, Kreis, Benjamin, Rodozov, Mircho, Mirman, Nathan, Nicolas Kaufman, Gala, Patterson, Juliet Ritchie, Ryd, Anders, Salvati, Emmanuele, Sun, Werner, Teo, Wee Don, Thom, Julia, Thompson, Joshua, Tucker, Jordan, Sultanov, Georgi, Weng, Yao, Winstrom, Lucas, Wittich, Peter, Winn, Dave, Abdullin, Salavat, Albrow, Michael, Anderson, Jacob, Apollinari, Giorgio, Bauerdick, Lothar AT, Beretvas, Andrew, Knünz, Valentin, Vutova, Mariana, Berryhill, Jeffrey, Bhat, Pushpalatha C, Burkett, Kevin, Butler, Joel Nathan, Chetluru, Vasundhara, Cheung, Harry, Chlebana, Frank, Cihangir, Selcuk, Elvira, Victor Daniel, Fisk, Ian, Dimitrov, Anton, Freeman, Jim, Gao, Yanyan, Gottschalk, Erik, Gray, Lindsey, Green, Dan, Grünendahl, Stefan, Gutsche, Oliver, Hare, Daryl, Harris, Robert M, Hirschauer, James, Glushkov, Ivan, Hooberman, Benjamin, Jindariani, Sergo, Johnson, Marvin, Joshi, Umesh, Kaadze, Ketino, Klima, Boaz, Kwan, Simon, Linacre, Jacob, Lincoln, Don, Lipton, Ron, Hadjiiska, Roumyana, Liu, Tiehui, Lykken, Joseph, Maeshima, Kaori, Marraffino, John Michael, Martinez Outschoorn, Verena Ingrid, Maruyama, Sho, Mason, David, McBride, Patricia, Mishra, Kalanand, Mrenna, Stephen, Kozhuharov, Venelin, Musienko, Yuri, Nahn, Steve, Newman-Holmes, Catherine, 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Pete, Martinez, German, Rodriguez, Jorge Luis, Adams, Todd, Askew, Andrew, Bochenek, Joseph, Krammer, Manfred, Chen, He-Sheng, Chen, Jie, Diamond, Brendan, Haas, Jeff, Hagopian, Sharon, Hagopian, Vasken, Johnson, Kurtis F, Prosper, Harrison, Veeraraghavan, Venkatesh, Weinberg, Marc, Baarmand, Marc M, Chen, Mingshui, Dorney, Brian, Hohlmann, Marcus, Kalakhety, Himali, Yumiceva, Francisco, Adams, Mark Raymond, Apanasevich, Leonard, Bazterra, Victor Eduardo, Betts, Russell Richard, Bucinskaite, Inga, Cavanaugh, Richard, Du, Ran, Evdokimov, Olga, Gauthier, Lucie, Gerber, Cecilia Elena, Hofman, David Jonathan, Khalatyan, Samvel, Kurt, Pelin, Moon, Dong Ho, O'Brien, Christine, Silkworth, Christopher, Turner, Paul, Jiang, Chun-Hua, Varelas, Nikos, Akgun, Ugur, Albayrak, Elif Asli, Bilki, Burak, Clarida, Warren, Dilsiz, Kamuran, Duru, Firdevs, Haytmyradov, Maksat, Merlo, Jean-Pierre, Mermerkaya, Hamit, Liang, Dong, Mestvirishvili, Alexi, Moeller, Anthony, Nachtman, Jane, Ogul, Hasan, Onel, Yasar, Ozok, Ferhat, Penzo, Aldo, Rahmat, Rahmat, Sen, Sercan, Tan, Ping, Liang, Song, Tiras, Emrah, Wetzel, James, Yetkin, Taylan, Yi, Kai, Barnett, Bruce Arnold, Blumenfeld, Barry, Bolognesi, Sara, Fehling, David, Gritsan, Andrei, Maksimovic, Petar, Meng, Xiangwei, Martin, Christopher, Swartz, Morris, Baringer, Philip, Bean, Alice, Benelli, Gabriele, Gray, Julia, Kenny III, Raymond Patrick, Murray, Michael, Noonan, Daniel, Sanders, Stephen, Plestina, Roko, Sekaric, Jadranka, Stringer, Robert, Wang, Quan, Wood, Jeffrey Scott, Barfuss, Anne-Fleur, Chakaberia, Irakli, Ivanov, Andrew, Khalil, Sadia, Makouski, Mikhail, Maravin, Yurii, Tao, Junquan, Saini, Lovedeep Kaur, Shrestha, Shruti, Svintradze, Irakli, Gronberg, Jeffrey, Lange, David, Rebassoo, Finn, Wright, Douglas, Baden, Drew, Calvert, Brian, Eno, Sarah Catherine, Wang, Xianyou, Gomez, Jaime, Hadley, Nicholas John, Kellogg, Richard G, Kolberg, Ted, Lu, Ying, Marionneau, Matthieu, Mignerey, Alice, Pedro, Kevin, Skuja, Andris, Temple, Jeffrey, Krätschmer, Ilse, Wang, Zheng, Tonjes, Marguerite, Tonwar, Suresh C, Apyan, Aram, Barbieri, Richard, Bauer, Gerry, Busza, Wit, Cali, Ivan Amos, Chan, Matthew, Di Matteo, Leonardo, Dutta, Valentina, Asawatangtrakuldee, Chayanit, Gomez Ceballos, Guillelmo, Goncharov, Maxim, Gulhan, Doga, Klute, Markus, Lai, Yue Shi, Lee, Yen-Jie, Levin, Andrew, Luckey, Paul David, Ma, Teng, Paus, Christoph, Ban, Yong, Ralph, Duncan, Roland, Christof, Roland, Gunther, Stephans, George, Stöckli, Fabian, Sumorok, Konstanty, Velicanu, Dragos, Veverka, Jan, Wyslouch, Bolek, Yang, Mingming, Guo, Yifei, Yoon, Sungho, Zanetti, Marco, Zhukova, Victoria, Dahmes, Bryan, De Benedetti, Abraham, Gude, Alexander, Kao, Shih-Chuan, Klapoetke, Kevin, Kubota, Yuichi, Mans, Jeremy, Li, Qiang, Pastika, Nathaniel, Rusack, Roger, Singovsky, Alexander, Tambe, Norbert, Turkewitz, Jared, Acosta, John Gabriel, Cremaldi, Lucien Marcus, Kroeger, Rob, Oliveros, Sandra, Perera, Lalith, Li, Wenbo, Sanders, David A, 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Wolszczak, Weronika, Bargassa, Pedrame, UCL - SST/IRMP - Institut de recherche en mathématique et physique, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CMS, Lista, Luca, Iorio, Alberto O M, And, Others., Merola, Mario, Chatrchyan, Serguei, Khachatryan, Vardan, Sirunyan, Albert M, Tumasyan, Armen, Adam, Wolfgang, Bergauer, Thoma, Dragicevic, Marko, Erö, Jano, Fabjan, Christian, Friedl, Marku, Fruehwirth, Rudolf, Ghete, Vasile Mihai, Hartl, Christian, Hörmann, Natascha, Hrubec, Josef, Jeitler, Manfred, Kiesenhofer, Wolfgang, Knünz, Valentin, Krammer, Manfred, Krätschmer, Ilse, Liko, Dietrich, Mikulec, Ivan, Rabady, Dinyar, Rahbaran, Babak, Rohringer, Herbert, Schöfbeck, Robert, Strauss, Josef, Taurok, Anton, Treberer Treberspurg, Wolfgang, Waltenberger, Wolfgang, Wulz, Claudia Elisabeth, Mossolov, Vladimir, Shumeiko, Nikolai, Suarez Gonzalez, Juan, Alderweireldt, Sara, Bansal, Monika, Bansal, Sunil, Cornelis, Tom, De Wolf, Eddi A, Janssen, Xavier, Knutsson, Albert, Luyckx, Sten, Ochesanu, Silvia, Roland, Benoit, Rougny, Romain, Van Haevermaet, Han, Van Mechelen, Pierre, Van Remortel, Nick, Van Spilbeeck, Alex, Blekman, Freya, Blyweert, Stijn, D'Hondt, Jorgen, 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Vanini, Sara, Zotto, Pierluigi, Zucchetta, Alberto, Zumerle, Gianni, Gabusi, Michele, Ratti, Sergio P, Riccardi, Cristina, Salvini, Paola, Vitulo, Paolo, Biasini, Maurizio, Bilei, Gian Mario, Fanò, Livio, Lariccia, Paolo, Mantovani, Giancarlo, Menichelli, Mauro, Romeo, Francesco, Saha, Anirban, Santocchia, Attilio, Spiezia, Aniello, Androsov, Konstantin, Azzurri, Paolo, Bagliesi, Giuseppe, Bernardini, Jacopo, Boccali, Tommaso, Broccolo, Giuseppe, Castaldi, Rino, Ciocci, Maria Agnese, Dell'Orso, Roberto, Donato, Silvio, Fiori, Francesco, Foà, Lorenzo, Giassi, Alessandro, Grippo, Maria Teresa, Kraan, Aafke, Ligabue, Franco, Lomtadze, Teimuraz, Martini, Luca, Messineo, Alberto, Moon, Chang Seong, Palla, Fabrizio, Rizzi, Andrea, Savoy Navarro, Aurore, Serban, Alin Titu, Spagnolo, Paolo, Squillacioti, Paola, Tenchini, Roberto, Tonelli, Guido, Venturi, Andrea, Verdini, Piero Giorgio, Vernieri, Caterina, Barone, Luciano, Cavallari, Francesca, Del Re, Daniele, Diemoz, Marcella, Grassi, Marco, 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Soon Kwon, Kim, Dong Hee, Kim, Gui Nyun, Kim, Ji Eun, Kim, Min Suk, Kong, Dae Jung, Lee, Sangeun, Oh, Young Do, Park, Hyangkyu, Sakharov, Alexandre, Son, Dong Chul, Kim, Jae Yool, Kim, Zero Jaeho, Song, Sanghyeon, Choi, Suyong, Gyun, Dooyeon, Hong, Byung Sik, Jo, Mihee, Kim, Hyunchul, Kim, Yongsun, Lee, Byounghoon, Lee, Kyong Sei, Park, Sung Keun, Roh, Youn, Choi, Minkyoo, Kim, Ji Hyun, Park, Chawon, Park, Inkyu, Park, Sangnam, Ryu, Geonmo, Choi, Young Il, Choi, Young Kyu, Goh, Junghwan, Kwon, Eunhyang, Lee, Jongseok, Seo, Hyunkwan, Yu, Intae, Juodagalvis, Andriu, Komaragiri, Jyothsna Rani, Castilla Valdez, Heriberto, De La Cruz Burelo, Eduard, Heredia de La Cruz, Ivan, Lopez Fernandez, Ricardo, Martínez Ortega, Jorge, Sánchez Hernández, Alberto, Villasenor Cendejas, Luis Manuel, Carrillo Moreno, Salvador, Vazquez Valencia, Fabiola, Salazar Ibarguen, Humberto Antonio, Casimiro Linares, Edgar, Morelos Pineda, Antonio, Krofcheck, David, Butler, Philip H, Doesburg, Robert, Reucroft, 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Fg, Ledovskoy, A. Fg, Li, H. Fg, Lin, C. Fg, Neu, C. Fg, Wood, J. Fg, Clarke, C. Fg, Harr, R. Fh, Karchin, P. E. Fh, Kottachchi Kankanamge Don, C. Fh, Lamichhane, P. Fh, Sturdy, J. Fh, Belknap, D. A. Fi, Carlsmith, D. Fi, Cepeda, M. Fi, Dasu, S. Fi, Dodd, L. Fi, Duric, S. Fi, Friis, E. Fi, Hall Wilton, R. Fi, Herndon, M. Fi, Hervé, A. Fi, Klabbers, P. Fi, Lanaro, A. Fi, Lazaridis, C. Fi, Levine, A. Fi, Loveless, R. Fi, Mohapatra, A. Fi, Ojalvo, I. Fi, Perry, T. Fi, Pierro, G. A. Fi, Polese, G. Fi, Ross, I. Fi, Sarangi, T. Fi, Savin, A. Fi, Smith, W. H. Fi, Vuosalo, C. Fi, Woods, N. Fi, Physics, Elementary Particle Physics, Universidad de Cantabria, Abbiendi, G., Bonacorsi, D., Braibant, S., Campanini, R., Capiluppi, P., Castro, A., Codispoti, G., Cuffiani, M., Fanfani, A., Guiducci, L., Rovelli, T., Siroli, G.P., Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and CMS Collaboration

Subjects
electroweak interaction: symmetry breaking, General Physics and Astronomy, interaction [p p], Elementary particle, Technicolor, 01 natural sciences, PARTICLE PHYSICS, LARGE HADRON COLLIDER, CMS, High Energy Physics - Experiment, Higgs particle: hadroproduction, High Energy Physics - Experiment (hep-ex), +Higgs+particle+vector+boson+anything%22">p p --> Higgs particle vector boson anything, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], p p: interaction, vector boson: associated production, Boson, 8000 GeV-cms [7000], Physics, tau: pair production, Scalar boson, pair production [bottom], Higgs field, CERN LHC Coll, pair production [tau], Physique des particules élémentaires, Higgs boson, 7000: 8000 GeV-cms, Higgs particle: decay modes, physics, Particle Physics - Experiment, Particle physics, coupling [Higgs particle], cms, FOS: Physical sciences, decay modes [Higgs particle], bottom: pair production, Standard Model, Nuclear physics, Physics and Astronomy (all), Fermions, 0103 physical sciences, ddc:530, +bottom+anti-bottom%22">Higgs particle --> bottom anti-bottom, 010306 general physics, experimental particle physics, Condensed Matter::Quantum Gases, Higgs particle: coupling, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, +tau%2B+tau%22">Higgs particle --> tau+ tau, symmetry breaking [electroweak interaction], hadroproduction [Higgs particle], associated production [vector boson], High Energy Physics::Experiment, Interacting boson model, experimental results
Abstract

The discovery of a new boson with a mass of approximately 125 GeV in 2012 at the Large Hadron Collider1,2,3 has heralded a new era in understanding the nature of electroweak symmetry breaking and possibly completing the standard model of particle physics4,5,6,7,8,9. Since the first observation in decays to γγ, WW and ZZ boson pairs, an extensive set of measurements of the mass10,11 and couplings to W and Z bosons11,12,13, as well as multiple tests of the spin-parity quantum numbers10,11,13,14, have revealed that the properties of the new boson are consistent with those of the long-sought agent responsible for electroweak symmetry breaking. An important open question is whether the new particle also couples to fermions, and in particular to down-type fermions, as the current measurements mainly constrain the couplings to the up-type top quark. Determination of the couplings to down-type fermions requires direct measurement of the corresponding Higgs boson decays, as recently reported by the Compact Muon Solenoid (CMS) experiment in the study of Higgs decays to bottom quarks15 and τ leptons16. Here, we report the combination of these two channels, which results in strong evidence for the direct coupling of the 125 GeV Higgs boson to down-type fermions, with an observed significance of 3.8 standard deviations, when 4.4 are expected., Nature Physics, 10, ISSN:1745-2473, ISSN:1745-2481

Published
2014
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49. Erratum to: Comparison of the Z/γ* + jets to γ + jets cross sections in pp collisions at s√=8

Author

CMS Collaboration, Khachatryan, Vardan, Erö, Janos, Ryckbosch, Dirk, Choi, Young-Il, Choi, Young Kyu, Goh, Junghwan, Kim, Donghyun, Kwon, Eunhyang, Lee, Jongseok, Yu, Intae, Juodagalvis, Andrius, Vaitkus, Juozas, Ibrahim, Zainol Abidin, Salva Diblen, Sinem, Komaragiri, Jyothsna Rani, Md Ali, Mohd Adli Bin, Mohamad Idris, Faridah, Wan Abdullah, Wan Ahmad Tajuddin, Casimiro Linares, Edgar, Castilla-Valdez, Heriberto, De La Cruz-Burelo, Eduard, Heredia-de La Cruz, Ivan, Hernandez-Almada, Alberto, Lopez-Fernandez, Ricardo, Sigamani, Michael, Ramirez Sanchez, Gabriel, Sánchez Hernández, Alberto, Carrillo Moreno, Salvador, Vazquez Valencia, Fabiola, Carpinteyro, Severiano, Pedraza, Isabel, Salazar Ibarguen, Humberto Antonio, Morelos Pineda, Antonio, Krofcheck, David, Butler, Philip H., Strobbe, Nadja, Reucroft, Steve, Ahmad, Ashfaq, Ahmad, Muhammad, Hassan, Qamar, Hoorani, Hafeez R., Khan, Wajid Ali, Khurshid, Taimoor, Shoaib, Muhammad, Bialkowska, Helena, Bluj, Michal, Tytgat, Michael, Boimska, Bożena, Frueboes, Tomasz, Górski, Maciej, Kazana, Malgorzata, Nawrocki, Krzysztof, Romanowska-Rybinska, Katarzyna, Szleper, Michal, Zalewski, Piotr, Brona, Grzegorz, Bunkowski, Karol, Van Driessche, Ward, Doroba, Krzysztof, Kalinowski, Artur, Konecki, Marcin, Krolikowski, Jan, Misiura, Maciej, Olszewski, Michal, Walczak, Marek, Bargassa, Pedrame, Beirão Da Cruz E Silva, Cristóvão, Di Francesco, Agostino, Yazgan, Efe, Faccioli, Pietro, Ferreira Parracho, Pedro Guilherme, Gallinaro, Michele, Lloret Iglesias, Lara, Nguyen, Federico, Rodrigues Antunes, Joao, Seixas, Joao, Toldaiev, Oleksii, Vadruccio, Daniele, Varela, Joao, Zaganidis, Nicolas, Vischia, Pietro, Afanasiev, Serguei, Bunin, Pavel, Gavrilenko, Mikhail, Golutvin, Igor, Gorbunov, Ilya, Kamenev, Alexey, Karjavin, Vladimir, Konoplyanikov, Viktor, Lanev, Alexander, Basegmez, Suzan, Malakhov, Alexander, Matveev, Viktor, Moisenz, Petr, Palichik, Vladimir, Perelygin, Victor, Shmatov, Sergey, Shulha, Siarhei, Skatchkov, 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Yang, Mingming, Zhukova, Victoria, Dahmes, Bryan, Finkel, Alexey, Du, Ran, Gude, Alexander, Kao, Shih-Chuan, Klapoetke, Kevin, Kubota, Yuichi, Mans, Jeremy, Nourbakhsh, Shervin, Rusack, Roger, Tambe, Norbert, Turkewitz, Jared, Acosta, John Gabriel, Sirunyan, Albert M., König, Axel, Jiang, Chun-Hua, Oliveros, Sandra, Avdeeva, Ekaterina, Bloom, Kenneth, Bose, Suvadeep, Claes, Daniel R., Dominguez, Aaron, Fangmeier, Caleb, Gonzalez Suarez, Rebeca, Kamalieddin, Rami, Keller, Jason, Plestina, Roko, Knowlton, Dan, Kravchenko, Ilya, Lazo-Flores, Jose, Meier, Frank, Monroy, Jose, Ratnikov, Fedor, Siado, Joaquin Emilo, Snow, Gregory R., Alyari, Maral, Dolen, James, Romeo, Francesco, George, Jimin, Godshalk, Andrew, Iashvili, Ia, Kaisen, Josh, Kharchilava, Avto, Kumar, Ashish, Rappoccio, Salvatore, Alverson, George, Barberis, Emanuela, Baumgartel, Darin, Shaheen, Sarmad Masood, Chasco, Matthew, Hortiangtham, Apichart, Massironi, Andrea, Morse, David Michael, Nash, David, Orimoto, Toyoko, Teixeira De Lima, Rafael, Trocino, Daniele, Wang, Ren-Jie, Wood, Darien, Tao, Junquan, Zhang, Jinzhong, Hahn, Kristan Allan, Kubik, Andrew, Mucia, Nicholas, Odell, Nathaniel, Pollack, Brian, Pozdnyakov, Andrey, Schmitt, Michael Henry, Stoynev, Stoyan, Sung, Kevin, Wang, Chunjie, Trovato, Marco, Velasco, Mayda, Won, Steven, Brinkerhoff, Andrew, Dev, Nabarun, Hildreth, Michael, Jessop, Colin, Karmgard, Daniel John, Kellams, Nathan, Lannon, Kevin, Wang, Zheng, Lynch, Sean, Marinelli, Nancy, Meng, Fanbo, Mueller, Charles, Musienko, Yuri, Pearson, Tessa, Planer, Michael, Ruchti, Randy, Smith, Geoffrey, Valls, Nil, Zhang, Huaqiao, Wayne, Mitchell, Wolf, Matthias, Woodard, Anna, Antonelli, Louis, Brinson, Jessica, Bylsma, Ben, Durkin, Lloyd Stanley, Flowers, Sean, Hart, Andrew, Hill, Christopher, Asawatangtrakuldee, Chayanit, Hughes, Richard, Kotov, Khristian, Ling, Ta-Yung, Liu, Bingxuan, Luo, Wuming, Puigh, Darren, Rodenburg, Marissa, Winer, Brian L., Wulsin, Howard Wells, Driga, Olga, Ban, Yong, Elmer, Peter, Hardenbrook, Joshua, Hebda, Philip, Koay, Sue Ann, Lujan, Paul, Marlow, Daniel, Medvedeva, Tatiana, Mooney, Michael, Olsen, James, Palmer, Christopher, Krammer, Manfred, Li, Qiang, Piroué, Pierre, Quan, Xiaohang, Saka, Halil, Stickland, David, Tully, Christopher, Werner, Jeremy Scott, Zuranski, Andrzej, Barnes, Virgil E., Benedetti, Daniele, Bortoletto, Daniela, Liu, Shuai, Gutay, Laszlo, Jha, Manoj, Jones, Matthew, Jung, Kurt, Kress, Matthew, Leonardo, Nuno, Miller, David Harry, Neumeister, Norbert, Primavera, Federica, Radburn-Smith, Benjamin Charles, Mao, Yajun, Shi, Xin, Shipsey, Ian, Silvers, David, Sun, Jian, Svyatkovskiy, Alexey, Wang, Fuqiang, Xie, Wei, Xu, Lingshan, Zablocki, Jakub, Parashar, Neeti, Qian, Si-Jin, Stupak, John, Adair, Antony, Akgun, Bora, Chen, Zhenyu, Ecklund, Karl Matthew, Geurts, Frank JM., Li, Wei, Michlin, Benjamin, Northup, Michael, Padley, Brian Paul, Wang, Dayong, Redjimi, Radia, Roberts, Jay, Rorie, Jamal, Tu, Zhoudunming, Zabel, James, Betchart, Burton, Bodek, Arie, de Barbaro, Pawel, Demina, Regina, Eshaq, Yossof, Xu, Zijun, Ferbel, Thomas, Galanti, Mario, Garcia-Bellido, Aran, Goldenzweig, Pablo, Han, Jiyeon, Harel, Amnon, Hindrichs, Otto, Khukhunaishvili, Aleko, Petrillo, Gianluca, Verzetti, Mauro, Zhang, Fengwangdong, Vishnevskiy, Dmitry, Demortier, Luc, Arora, Sanjay, Barker, Anthony, Chou, John Paul, Contreras-Campana, Christian, Contreras-Campana, Emmanuel, Duggan, Daniel, Ferencek, Dinko, Gershtein, Yuri, Zhang, Linlin, Gray, Richard, Halkiadakis, Eva, Hidas, Dean, Hughes, Elliot, Kaplan, Steven, Kunnawalkam Elayavalli, Raghav, Lath, Amitabh, Panwalkar, Shruti, Park, Michael, Salur, Sevil, Zou, Wei, Schnetzer, Steve, Sheffield, David, Somalwar, Sunil, Stone, Robert, Thomas, Scott, Thomassen, Peter, Walker, Matthew, Foerster, Mark, Rose, Keith, Spanier, Stefan, Avila, Carlos, York, Andrew, Bouhali, Othmane, Castaneda Hernandez, Alfredo, Dalchenko, Mykhailo, De Mattia, Marco, Delgado, Andrea, Dildick, Sven, Eusebi, Ricardo, Flanagan, Will, Gilmore, Jason, Krätschmer, Ilse, Cabrera, Andrés, Kamon, Teruki, Krutelyov, Vyacheslav, Montalvo, Roy, Mueller, Ryan, Osipenkov, Ilya, Pakhotin, Yuriy, Patel, Rishi, Perloff, Alexx, Roe, Jeffrey, Rose, Anthony, Chaparro Sierra, Luisa Fernanda, Safonov, Alexei, Suarez, Indara, Tatarinov, Aysen, Ulmer, Keith, Akchurin, Nural, Cowden, Christopher, Damgov, Jordan, Dragoiu, Cosmin, Dudero, Phillip Russell, Faulkner, James, Florez, Carlos, Kunori, Shuichi, Lamichhane, Kamal, Lee, Sung Won, Libeiro, Terence, Undleeb, Sonaina, Volobouev, Igor, Appelt, Eric, Delannoy, Andrés G., Greene, Senta, Gurrola, Alfredo, Gomez, Juan Pablo, Janjam, Ravi, Johns, Willard, Maguire, Charles, Mao, Yaxian, Melo, Andrew, Sheldon, Paul, Snook, Benjamin, Tuo, Shengquan, Velkovska, Julia, Xu, Qiao, Gomez Moreno, Bernardo, Arenton, Michael Wayne, Boutle, Sarah, Cox, Bradley, Francis, Brian, Goodell, Joseph, Hirosky, Robert, Ledovskoy, Alexander, Li, Hengne, Lin, Chuanzhe, Neu, Christopher, Sanabria, Juan Carlos, Wolfe, Evan, Wood, John, Xia, Fan, Clarke, Christopher, Harr, Robert, Karchin, Paul Edmund, Kottachchi Kankanamge Don, Chamath, Lamichhane, Pramod, Sturdy, Jared, Belknap, Donald, Godinovic, Nikola, Carlsmith, Duncan, Cepeda, Maria, Christian, Allison, Dasu, Sridhara, Dodd, Laura, Duric, Senka, Friis, Evan, Gomber, Bhawna, Grothe, Monika, Hall-Wilton, Richard, Lelas, Damir, Herndon, Matthew, Hervé, Alain, Klabbers, Pamela, Lanaro, Armando, Levine, Aaron, Long, Kenneth, Loveless, Richard, Mohapatra, Ajit, Ojalvo, Isabel, Perry, Thomas, Polic, Dunja, Pierro, Giuseppe Antonio, Polese, Giovanni, Ross, Ian, Ruggles, Tyler, Sarangi, Tapas, Savin, Alexander, Smith, Nicholas, Smith, Wesley H., Taylor, Devin, Woods, Nathaniel, Puljak, Ivica, Liko, Dietrich, Antunovic, Zeljko, Kovac, Marko, Brigljevic, Vuko, Kadija, Kreso, Luetic, Jelena, Sudic, Lucija, Attikis, Alexandros, Mavromanolakis, Georgios, Mousa, Jehad, Nicolaou, Charalambos, Mikulec, Ivan, Ptochos, Fotios, Razis, Panos A., Rykaczewski, Hans, Bodlak, Martin, Finger, Miroslav, Finger jr., Michael, Ali, Ahmed, Aly, Reham, Aly, Shereen, Assran, Yasser, Rabady, Dinyar, Ellithi Kamel, Ali, Lotfy, Ahmad, Mahmoud, Mohammed, Masod, Rehab, Radi, Amr, Calpas, Betty, Kadastik, Mario, Murumaa, Marion, Raidal, Martti, Tiko, Andres, Rahbaran, Babak, Veelken, Christian, Eerola, Paula, Voutilainen, Mikko, Härkönen, Jaakko, Karimäki, Veikko, Kinnunen, Ritva, Lampén, Tapio, Lassila-Perini, Kati, Lehti, Sami, Lindén, Tomas, Rohringer, Herbert, Luukka, Panja-Riina, Mäenpää, Teppo, Peltola, Timo, Tuominen, Eija, Tuominiemi, Jorma, Tuovinen, Esa, Wendland, Lauri, Talvitie, Joonas, Tuuva, Tuure, Besancon, Marc, Schieck, Jochen, Couderc, Fabrice, Dejardin, Marc, Denegri, Daniel, Fabbro, Bernard, Faure, Jean-Louis, Favaro, Carlotta, Ferri, Federico, Ganjour, Serguei, Givernaud, Alain, Gras, Philippe, Schöfbeck, Robert, Hamel de Monchenault, Gautier, Jarry, Patrick, Locci, Elizabeth, Malcles, Julie, Rander, John, Rosowsky, André, Titov, Maksym, Zghiche, Amina, Baffioni, Stephanie, Beaudette, Florian, Tumasyan, Armen, Strauss, Josef, Busson, Philippe, Cadamuro, Luca, Chapon, Emilien, Charlot, Claude, Dahms, Torsten, Davignon, Olivier, Filipovic, Nicolas, Florent, Alice, Granier de Cassagnac, Raphael, Mastrolorenzo, Luca, Treberer-Treberspurg, Wolfgang, Miné, Philippe, Naranjo, Ivo Nicolas, Nguyen, Matthew, Ochando, Christophe, Ortona, Giacomo, Paganini, Pascal, Regnard, Simon, Salerno, Roberto, Sauvan, Jean-Baptiste, Sirois, Yves, Waltenberger, Wolfgang, Strebler, Thomas, Yilmaz, Yetkin, Zabi, Alexandre, Agram, Jean-Laurent, Andrea, Jeremy, Aubin, Alexandre, Bloch, Daniel, Brom, Jean-Marie, Buttignol, Michael, Chabert, Eric Christian, Wulz, Claudia-Elisabeth, Chanon, Nicolas, Collard, Caroline, Conte, Eric, Fontaine, Jean-Charles, Gelé, Denis, Goerlach, Ulrich, Goetzmann, Christophe, Le Bihan, Anne-Catherine, Merlin, Jeremie Alexandre, Skovpen, Kirill, Mossolov, Vladimir, Van Hove, Pierre, Gadrat, Sébastien, Beauceron, Stephanie, Beaupere, Nicolas, Bernet, Colin, Boudoul, Gaelle, Bouvier, Elvire, Brochet, Sébastien, Carrillo Montoya, Camilo Andres, Chasserat, Julien, Shumeiko, Nikolai, Chierici, Roberto, Contardo, Didier, Courbon, Benoit, Depasse, Pierre, El Mamouni, Houmani, Fan, Jiawei, Fay, Jean, Gascon, Susan, Gouzevitch, Maxime, Ille, Bernard, Suarez Gonzalez, Juan, Laktineh, Imad Baptiste, Lethuillier, Morgan, Mirabito, Laurent, Pequegnot, Anne-Laure, Perries, Stephane, Ruiz Alvarez, José David, Sabes, David, Sgandurra, Louis, Sordini, Viola, Vander Donckt, Muriel, Alderweireldt, Sara, Verdier, Patrice, Viret, Sébastien, Xiao, Hong, Lomidze, David, Autermann, Christian Tobias, Beranek, Sarah, Edelhoff, Matthias, Feld, Lutz, Heister, Arno, Kiesel, Maximilian Knut, Cornelis, Tom, Klein, Katja, Lipinski, Martin, Ostapchuk, Andrey, Preuten, Marius, Raupach, Frank Arthur, Sammet, Jan, Schael, Stefan, Schulte, Jan-Frederik, Verlage, Tobias Anton, Weber, Hendrik, De Wolf, Eddi A., Wittmer, Bruno, Zhukov, Valery, Ata, Metin, Brodski, Michael, Dietz-Laursonn, Erik, Duchardt, Deborah, Endres, Matthias, Erdmann, Martin, Erdweg, Sören, Esch, Thomas, Adam, Wolfgang, Janssen, Xavier, Fischer, Robert, Güth, Andreas, Hebbeker, Thomas, Heidemann, Carsten Andreas, Hoepfner, Kerstin, Klingebiel, Dennis, Knutzen, Simon, Kreuzer, Peter, Merschmeyer, Markus Karl, Meyer, Arnd, Knutsson, Albert, Millet, Philipp, Olschewski, Mark, Padeken, Klaas Ole, Papacz, Paul Jakob, Pook, Tobias, Radziej, Markus, Reithler, Hans, Rieger, Marcel, Sonnenschein, Lars, Teyssier, Daniel, Lauwers, Jasper, Thüer, Sebastian, Cherepanov, Vladimir, Erdogan, Yusuf, Flügge, Günter, Geenen, Heiko, Geisler, Matthias, Haj Ahmad, Wael, Höhle, Felix, Kargoll, Bastian, Kreß, Thomas, Luyckx, Sten, Küssel, Yvonne, Künsken, Andreas, Lingemann, Joschka Phillip, Nowack, Andreas, Nugent, Ian Michael, Pistone, Claudia, Pooth, Oliver, Stahl, Achim, Aldaya Martin, Maria, Asin, Ivan, Ochesanu, Silvia, Bartosik, Nazar, Behnke, Olaf, Behrens, Ulf, Bell, Alan James, Borras, Kerstin, Burgmeier, Armin, Cakir, Altan, Calligaris, Luigi, Campbell, Alan, Choudhury, Somnath, Rougny, Romain, Costanza, Francesco, Diez Pardos, Carmen, Dolinska, Ganna, Dooling, Samantha, Dorland, Tyler, Eckerlin, Guenter, Eckstein, Doris, Eichhorn, Thomas, Flucke, Gero, Gallo, Elisabetta, Van De Klundert, Merijn, Garay Garcia, Jasone, Geiser, Achim, Gizhko, Andrii, Gunnellini, Paolo, Hauk, Johannes, Hempel, Maria, Jung, Hannes, Kalogeropoulos, Alexis, Karacheban, Olena, Kasemann, Matthias, Van Haevermaet, Hans, Katsas, Panagiotis, Kieseler, Jan, Kleinwort, Claus, Korol, Ievgen, Lange, Wolfgang, Leonard, Jessica, Lipka, Katerina, Lobanov, Artur, Mankel, Rainer, Marfin, Ihar, Van Mechelen, Pierre, Melzer-Pellmann, Isabell-Alissandra, Meyer, Andreas Bernhard, Mittag, Gregor, Mnich, Joachim, Mussgiller, Andreas, Naumann-Emme, Sebastian, Nayak, Aruna, Ntomari, Eleni, Perrey, Hanno, Pitzl, Daniel, Van Remortel, Nick, Placakyte, Ringaile, Raspereza, Alexei, Ribeiro Cipriano, Pedro M., Roland, Benoit, Sahin, Mehmet Özgür, Salfeld-Nebgen, Jakob, Saxena, Pooja, Schoerner-Sadenius, Thomas, Schröder, Matthias, Seitz, Claudia, Asilar, Ece, Van Spilbeeck, Alex, Spannagel, Simon, Trippkewitz, Karim Damun, Wissing, Christoph, Blobel, Volker, Centis Vignali, Matteo, Draeger, Arne-Rasmus, Erfle, Joachim, Garutti, Erika, Goebel, Kristin, Gonzalez, Daniel, Abu Zeid, Shimaa, Görner, Martin, Haller, Johannes, Hoffmann, Malte, Höing, Rebekka Sophie, Junkes, Alexandra, Kirschenmann, Henning, Klanner, Robert, Kogler, Roman, Lapsien, Tobias, Lenz, Teresa, Blekman, Freya, Marchesini, Ivan, Marconi, Daniele, Nowatschin, Dominik, Ott, Jochen, Peiffer, Thomas, Perieanu, Adrian, Pietsch, Niklas, Poehlsen, Jennifer, Rathjens, Denis, Sander, Christian, D'Hondt, Jorgen, Schettler, Hannes, Schleper, Peter, Schlieckau, Eike, Schmidt, Alexander, Seidel, Markus, Sola, Valentina, Stadie, Hartmut, Steinbrück, Georg, Tholen, Heiner, Troendle, Daniel, Daci, Nadir, Usai, Emanuele, Vanelderen, Lukas, Vanhoefer, Annika, Akbiyik, Melike, Barth, Christian, Baus, Colin, Berger, Joram, Böser, Christian, Butz, Erik, Chwalek, Thorsten, De Bruyn, Isabelle, Colombo, Fabio, De Boer, Wim, Descroix, Alexis, Dierlamm, Alexander, Feindt, Michael, Frensch, Felix, Giffels, Manuel, Gilbert, Andrew, Hartmann, Frank, Husemann, Ulrich, Deroover, Kevin, Katkov, Igor, Kornmayer, Andreas, Lobelle Pardo, Patricia, Mozer, Matthias Ulrich, Müller, Thomas, Plagge, Michael, Quast, Gunter, Rabbertz, Klaus, Röcker, Steffen, Heracleous, Natalie, Roscher, Frank, Simonis, Hans-Jürgen, Stober, Fred-Markus Helmut, Ulrich, Ralf, Wagner-Kuhr, Jeannine, Wayand, Stefan, Weiler, Thomas, Wöhrmann, Clemens, Wolf, Roger, Anagnostou, Georgios, Keaveney, James, Daskalakis, Georgios, Geralis, Theodoros, Giakoumopoulou, Viktoria Athina, Kyriakis, Aristotelis, Loukas, Demetrios, Markou, Athanasios, Psallidas, Andreas, Topsis-Giotis, Iasonas, Agapitos, Antonis, Kesisoglou, Stilianos, Lowette, Steven, Panagiotou, Apostolos, Saoulidou, Niki, Tziaferi, Eirini, Evangelou, Ioannis, Flouris, Giannis, Foudas, Costas, Kokkas, Panagiotis, Loukas, Nikitas, Manthos, Nikolaos, Papadopoulos, Ioannis, Bergauer, Thomas, Moreels, Lieselotte, Paradas, Evangelos, Strologas, John, Bencze, Gyorgy, Hajdu, Csaba, Hazi, Andras, Hidas, Pàl, Horvath, Dezso, Sikler, Ferenc, Veszpremi, Viktor, Vesztergombi, Gyorgy, Olbrechts, Annik, Zsigmond, Anna Julia, Beni, Noemi, Czellar, Sandor, Karancsi, János, Molnar, Jozsef, Palinkas, Jozsef, Szillasi, Zoltan, Bartók, Márton, Makovec, Alajos, Raics, Peter, Python, Quentin, Trocsanyi, Zoltan Laszlo, Mal, Prolay, Mandal, Koushik, Sahoo, Niladribihari, Swain, Sanjay Kumar, Bansal, Sunil, Beri, Suman Bala, Bhatnagar, Vipin, Chawla, Ridhi, Gupta, Ruchi, Strom, Derek, Bhawandeep, Bhawandeep, Kalsi, Amandeep Kaur, Kaur, Anterpreet, Kaur, Manjit, Kumar, Ramandeep, Mehta, Ankita, Mittal, Monika, Nishu, Nishu, Singh, Jasbir, Walia, Genius, Tavernier, Stefaan, Kumar, Ashok, Kumar, Arun, Bhardwaj, Ashutosh, Choudhary, Brajesh C., Garg, Rocky Bala, Kumar, Ajay, Malhotra, Shivali, Naimuddin, Md, Ranjan, Kirti, Sharma, Ramkrishna, Van Doninck, Walter, Sharma, Varun, Banerjee, Sunanda, Bhattacharya, Satyaki, Chatterjee, Kalyanmoy, Dey, Sourav, Dutta, Suchandra, Jain, Sandhya, Jain, Shilpi, Khurana, Raman, Majumdar, Nayana, Van Mulders, Petra, Modak, Atanu, Mondal, Kuntal, Mukherjee, Swagata, Mukhopadhyay, Supratik, Roy, Ashim, Roy, Debarati, Roy Chowdhury, Suvankar, Sarkar, Subir, Sharan, Manoj, Abdulsalam, Abdulla, Van Onsem, Gerrit Patrick, Chudasama, Ruchi, Dutta, Dipanwita, Jha, Vishwajeet, Kumar, Vineet, Mohanty, Ajit Kumar, Pant, Lalit Mohan, Shukla, Prashant, Topkar, Anita, Aziz, Tariq, Banerjee, Sudeshna, Van Parijs, Isis, Bhowmik, Sandeep, Chatterjee, Rajdeep Mohan, Dewanjee, Ram Krishna, Dugad, Shashikant, Ganguly, Sanmay, Ghosh, Saranya, Guchait, Monoranjan, Gurtu, Atul, Kole, Gouranga, Kumar, Sanjeev, Barria, Patrizia, Mahakud, Bibhuprasad, Maity, Manas, Majumder, Gobinda, Mazumdar, Kajari, Mitra, Soureek, Mohanty, Gagan Bihari, Parida, Bibhuti, Sarkar, Tanmay, Sudhakar, Katta, Sur, Nairit, Brandstetter, Johannes, Caillol, Cécile, Sutar, Bajrang, Wickramage, Nadeesha, Sharma, Seema, Bakhshiansohi, Hamed, Behnamian, Hadi, Etesami, Seyed Mohsen, Fahim, Ali, Goldouzian, Reza, Khakzad, Mohsen, Mohammadi Najafabadi, Mojtaba, Clerbaux, Barbara, Naseri, Mohsen, Paktinat Mehdiabadi, Saeid, Rezaei Hosseinabadi, Ferdos, Safarzadeh, Batool, Zeinali, Maryam, Felcini, Marta, Grunewald, Martin, Abbrescia, Marcello, Calabria, Cesare, Caputo, Claudio, De Lentdecker, Gilles, Chhibra, Simranjit Singh, Colaleo, Anna, Creanza, Donato, Cristella, Leonardo, De Filippis, Nicola, De Palma, Mauro, Fiore, Luigi, Iaselli, Giuseppe, Maggi, Giorgio, Maggi, Marcello, Delannoy, Hugo, Miniello, Giorgia, My, Salvatore, Nuzzo, Salvatore, Pompili, Alexis, Pugliese, Gabriella, Radogna, Raffaella, Ranieri, Antonio, Selvaggi, Giovanna, Silvestris, Lucia, Dobur, Didar, Venditti, Rosamaria, Verwilligen, Piet, Abbiendi, Giovanni, Battilana, Carlo, Benvenuti, Alberto, Bonacorsi, Daniele, Braibant-Giacomelli, Sylvie, Brigliadori, Luca, Campanini, Renato, Capiluppi, Paolo, Fasanella, Giuseppe, Castro, Andrea, Cavallo, Francesca Romana, Codispoti, Giuseppe, Cuffiani, Marco, Dallavalle, Gaetano-Marco, Fabbri, Fabrizio, Fanfani, Alessandra, Fasanella, Daniele, Giacomelli, Paolo, Grandi, Claudio, Favart, Laurent, Guiducci, Luigi, Marcellini, Stefano, Masetti, Gianni, Montanari, Alessandro, Navarria, Francesco, Perrotta, Andrea, Rossi, Antonio, Rovelli, Tiziano, Siroli, Gian Piero, Tosi, Nicolò, Gay, Arnaud, Travaglini, Riccardo, Cappello, Gigi, Chiorboli, Massimiliano, Costa, Salvatore, Giordano, Ferdinando, Potenza, Renato, Tricomi, Alessia, Tuve, Cristina, Barbagli, Giuseppe, Ciulli, Vitaliano, Grebenyuk, Anastasia, Civinini, Carlo, D'Alessandro, Raffaello, Focardi, Ettore, Gonzi, Sandro, Gori, Valentina, Lenzi, Piergiulio, Meschini, Marco, Paoletti, Simone, Sguazzoni, Giacomo, Tropiano, Antonio, Léonard, Alexandre, Viliani, Lorenzo, Benussi, Luigi, Bianco, Stefano, Fabbri, Franco, Piccolo, Davide, Calvelli, Valerio, Ferro, Fabrizio, Lo Vetere, Maurizio, Robutti, Enrico, Tosi, Silvano, Brondolin, Erica, Mohammadi, Abdollah, Dinardo, Mauro Emanuele, Fiorendi, Sara, Gennai, Simone, Gerosa, Raffaele, Ghezzi, Alessio, Govoni, Pietro, Lucchini, Marco Toliman, Malvezzi, Sandra, Manzoni, Riccardo Andrea, Marzocchi, Badder, Perniè, Luca, Menasce, Dario, Moroni, Luigi, Paganoni, Marco, Pedrini, Daniele, Ragazzi, Stefano, Redaelli, Nicola, Tabarelli de Fatis, Tommaso, Buontempo, Salvatore, Cavallo, Nicola, Di Guida, Salvatore, Randle-conde, Aidan, Esposito, Marco, Fabozzi, Francesco, Iorio, Alberto Orso Maria, Lanza, Giuseppe, Lista, Luca, Meola, Sabino, Merola, Mario, Paolucci, Pierluigi, Sciacca, Crisostomo, Thyssen, Filip, Reis, Thomas, Azzi, Patrizia, Bacchetta, Nicola, Bellato, Marco, Bisello, Dario, Carlin, Roberto, Carvalho Antunes De Oliveira, Alexandra, Checchia, Paolo, Dall'Osso, Martino, Dorigo, Tommaso, Dosselli, Umberto, Seva, Tomislav, Fantinel, Sergio, Gasparini, Fabrizio, Gasparini, Ugo, Gozzelino, Andrea, Lacaprara, Stefano, Margoni, Martino, Meneguzzo, Anna Teresa, Pazzini, Jacopo, Pozzobon, Nicola, Ronchese, Paolo, Thomas, Laurent, Simonetto, Franco, Torassa, Ezio, Tosi, Mia, Zanetti, Marco, Zotto, Pierluigi, Zucchetta, Alberto, Zumerle, Gianni, Braghieri, Alessandro, Gabusi, Michele, Magnani, Alice, Vander Velde, Catherine, Ratti, Sergio P., Re, Valerio, Riccardi, Cristina, Salvini, Paola, Vai, Ilaria, Vitulo, Paolo, Alunni Solestizi, Luisa, Biasini, Maurizio, Bilei, Gian Mario, Ciangottini, Diego, Vanlaer, Pascal, Fanò, Livio, Lariccia, Paolo, Mantovani, Giancarlo, Menichelli, Mauro, Saha, Anirban, Santocchia, Attilio, Spiezia, Aniello, Androsov, Konstantin, Azzurri, Paolo, Bagliesi, Giuseppe, Wang, Jian, Bernardini, Jacopo, Boccali, Tommaso, Broccolo, Giuseppe, Castaldi, Rino, Ciocci, Maria Agnese, Dell'Orso, Roberto, Donato, Silvio, Fedi, Giacomo, Fiori, Francesco, Foà, Lorenzo, Zenoni, Florian, Giassi, Alessandro, Grippo, Maria Teresa, Ligabue, Franco, Lomtadze, Teimuraz, Martini, Luca, Messineo, Alberto, Palla, Fabrizio, Rizzi, Andrea, Savoy-Navarro, Aurore, Serban, Alin Titus, Dragicevic, Marko, Beernaert, Kelly, Spagnolo, Paolo, Squillacioti, Paola, Tenchini, Roberto, Tonelli, Guido, Venturi, Andrea, Verdini, Piero Giorgio, Barone, Luciano, Cavallari, Francesca, D'imperio, Giulia, Del Re, Daniele, Benucci, Leonardo, Diemoz, Marcella, Gelli, Simone, Jorda, Clara, Longo, Egidio, Margaroli, Fabrizio, Meridiani, Paolo, Micheli, Francesco, Organtini, Giovanni, Paramatti, Riccardo, Preiato, Federico, Cimmino, Anna, Rahatlou, Shahram, Rovelli, Chiara, Santanastasio, Francesco, Soffi, Livia, Traczyk, Piotr, Amapane, Nicola, Arcidiacono, Roberta, Argiro, Stefano, Arneodo, Michele, Bellan, Riccardo, Crucy, Shannon, Biino, Cristina, Cartiglia, Nicolo, Casasso, Stefano, Costa, Marco, Covarelli, Roberto, Degano, Alessandro, Demaria, Natale, Finco, Linda, Kiani, Bilal, Mariotti, Chiara, Fagot, Alexis, Maselli, Silvia, Migliore, Ernesto, Monaco, Vincenzo, Musich, Marco, Obertino, Maria Margherita, Pacher, Luca, Pastrone, Nadia, Pelliccioni, Mario, Pinna Angioni, Gian Luca, Romero, Alessandra, Garcia, Guillaume, Ruspa, Marta, Sacchi, Roberto, Solano, Ada, Staiano, Amedeo, Tamponi, Umberto, Belforte, Stefano, Candelise, Vieri, Casarsa, Massimo, Cossutti, Fabio, Della Ricca, Giuseppe, Gul, Muhammad, Gobbo, Benigno, La Licata, Chiara, Marone, Matteo, Schizzi, Andrea, Umer, Tomo, Zanetti, Anna, Chang, Sunghyun, Kropivnitskaya, Anna, Nam, Soon-Kwon, Kim, Dong Hee, Mccartin, Joseph, Kim, Gui Nyun, Kim, Min Suk, Kong, Dae Jung, Lee, Sangeun, Oh, Young Do, Sakharov, Alexandre, Son, Dong-Chul, Kim, Hyunsoo, Kim, Tae Jeong, Ryu, Min Sang, Ocampo Rios, Alberto Andres, Song, Sanghyeon, Choi, Suyong, Go, Yeonju, Gyun, Dooyeon, Hong, Byung-Sik, Jo, Mihee, Kim, Hyunchul, Kim, Yongsun, Lee, Byounghoon, Lee, Kisoo, Poyraz, Deniz, Lee, Kyong Sei, Lee, Songkyo, Park, Sung Keun, Roh, Youn, Yoo, Hwi Dong, Choi, Minkyoo, Kim, Ji Hyun, Lee, Jason Sang Hun, Park, Inkyu, and Ryu, Geonmo

Subjects
p p: scattering, jet: multiplicity, jet: transverse momentum, transverse momentum dependence, transverse momentum [jet], Physics, Particles & Fields, quantum chromodynamics, scattering [p p], ddc:530, associated production [Z0], differential cross section: ratio, 01 Mathematical Sciences, 8000 GeV-cms, Science & Technology, 02 Physical Sciences, CMS, Physics, multiplicity: dependence, Nuclear & Particles Physics, Z0: associated production, ratio [differential cross section], photon: associated production, dependence [multiplicity], CERN LHC Coll, associated production [photon], differential cross section, Physical Sciences, colliding beams [p p], multiplicity [jet], p p: colliding beams, experimental results
Abstract

Journal of high energy physics : JHEP 2016(4), 010 (2015). doi:10.1007/JHEP04(2016)010, Published by Springer, Berlin ; Heidelberg

Published
2016
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50. Search for massive WH resonances decaying into the $\ell \nu\mathrm{ b \bar{b} }$ final state at $\sqrt{s}= $ 8 TeV

Author

Khachatryan, Vardan, Sirunyan, Albert M, Flechl, Martin, Ryckbosch, Dirk, Goh, Junghwan, Kim, Donghyun, Kwon, Eunhyang, Lee, Jongseok, Yu, Intae, Dudenas, Vytautas, Juodagalvis, Andrius, Vaitkus, Juozas, Ahmed, Ijaz, Ibrahim, Zainol Abidin, Salva Diblen, Sinem, Komaragiri, Jyothsna Rani, Md Ali, Mohd Adli Bin, Mohamad Idris, Faridah, Wan Abdullah, Wan Ahmad Tajuddin, Yusli, Mohd Nizam, Casimiro Linares, Edgar, Castilla-Valdez, Heriberto, De La Cruz-Burelo, Eduard, Heredia-De La Cruz, Ivan, Hernandez-Almada, Alberto, Sigamani, Michael, Lopez-Fernandez, Ricardo, Sánchez Hernández, Alberto, Carrillo Moreno, Salvador, Vazquez Valencia, Fabiola, Pedraza, Isabel, Salazar Ibarguen, Humberto Antonio, Morelos Pineda, Antonio, Krofcheck, David, Butler, Philip H, Ahmad, Ashfaq, Tytgat, Michael, Ahmad, Muhammad, Hassan, Qamar, Hoorani, Hafeez R, Khan, Wajid Ali, Khurshid, Taimoor, Shoaib, Muhammad, Bialkowska, Helena, Bluj, Michal, Boimska, Bożena, Frueboes, Tomasz, Van Driessche, Ward, Górski, Maciej, Kazana, Malgorzata, Nawrocki, Krzysztof, Romanowska-Rybinska, Katarzyna, Szleper, Michal, Zalewski, Piotr, Brona, Grzegorz, Bunkowski, Karol, Byszuk, Adrian, Doroba, Krzysztof, Yazgan, Efe, Kalinowski, Artur, Konecki, Marcin, Krolikowski, Jan, Misiura, Maciej, Olszewski, Michal, Walczak, Marek, Bargassa, Pedrame, Beirão Da Cruz E Silva, Cristóvão, Di Francesco, Agostino, Faccioli, Pietro, Zaganidis, Nicolas, Ferreira Parracho, Pedro Guilherme, Gallinaro, Michele, Leonardo, Nuno, Lloret Iglesias, Lara, Nguyen, Federico, Rodrigues Antunes, Joao, Seixas, Joao, Toldaiev, Oleksii, Vadruccio, Daniele, Varela, Joao, Basegmez, Suzan, Vischia, Pietro, Afanasiev, Serguei, Bunin, Pavel, Gavrilenko, Mikhail, Golutvin, Igor, Gorbunov, Ilya, Kamenev, Alexey, Karjavin, Vladimir, Konoplyanikov, Viktor, Lanev, Alexander, Beluffi, Camille, Malakhov, Alexander, Matveev, Viktor, Moisenz, Petr, Palichik, Vladimir, Perelygin, Victor, Shmatov, Sergey, Shulha, Siarhei, Skatchkov, Nikolai, Smirnov, Vitaly, Zarubin, Anatoli, Bondu, Olivier, Golovtsov, Victor, Ivanov, Yury, Kim, Victor, Kuznetsova, Ekaterina, Levchenko, Petr, Murzin, Victor, Oreshkin, Vadim, Smirnov, Igor, Sulimov, Valentin, Uvarov, Lev, Friedl, Markus, Brochet, Sébastien, Vavilov, Sergey, Vorobyev, Alexey, Andreev, Yuri, Dermenev, Alexander, Gninenko, Sergei, Golubev, Nikolai, Karneyeu, Anton, Kirsanov, Mikhail, Krasnikov, Nikolai, Pashenkov, Anatoli, Bruno, Giacomo, Tlisov, Danila, Toropin, Alexander, Epshteyn, Vladimir, Gavrilov, Vladimir, Lychkovskaya, Natalia, Popov, Vladimir, Pozdnyakov, Ivan, Safronov, Grigory, Spiridonov, Alexander, Vlasov, Evgueni, Caudron, Adrien, Zhokin, Alexander, Bylinkin, Alexander, Andreev, Vladimir, Azarkin, Maksim, Dremin, Igor, Kirakosyan, Martin, Leonidov, Andrey, Mesyats, Gennady, Rusakov, Sergey V, Baskakov, Alexey, Ceard, Ludivine, Belyaev, Andrey, Boos, Edouard, Bunichev, Viacheslav, Dubinin, Mikhail, Dudko, Lev, Ershov, Alexander, Gribushin, Andrey, Klyukhin, Vyacheslav, Kodolova, Olga, Lokhtin, Igor, Da Silveira, Gustavo Gil, Miagkov, Igor, Obraztsov, Stepan, Savrin, Viktor, Snigirev, Alexander, Azhgirey, Igor, Bayshev, Igor, Bitioukov, Sergei, Kachanov, Vassili, Kalinin, Alexey, Konstantinov, Dmitri, Delaere, Christophe, Krychkine, Victor, Petrov, Vladimir, Ryutin, Roman, Sobol, Andrei, Tourtchanovitch, Leonid, Troshin, Sergey, Tyurin, Nikolay, Uzunian, Andrey, Volkov, Alexey, Adzic, Petar, Favart, Denis, Milosevic, Jovan, Rekovic, Vladimir, Alcaraz Maestre, Juan, Calvo, Enrique, Cerrada, Marcos, Chamizo Llatas, Maria, Colino, Nicanor, De La Cruz, Begona, Delgado Peris, Antonio, Domínguez Vázquez, Daniel, Forthomme, Laurent, Escalante Del Valle, Alberto, Fernandez Bedoya, Cristina, Fernández Ramos, Juan Pablo, Flix, Jose, Fouz, Maria Cruz, Garcia-Abia, Pablo, Gonzalez Lopez, Oscar, Goy Lopez, Silvia, Hernandez, Jose M, Josa, Maria Isabel, Giammanco, Andrea, Navarro De Martino, Eduardo, Pérez-Calero Yzquierdo, Antonio María, Puerta Pelayo, Jesus, 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Smith, Dominic, Smith, Vincent J, Carvalho, Wagner, Bell, Ken W, Belyaev, Alexander, Brew, Christopher, Brown, Robert M, Calligaris, Luigi, Cieri, Davide, Cockerill, David JA, Coughlan, John A, Harder, Kristian, Harper, Sam, Chinellato, Jose, Olaiya, Emmanuel, Petyt, David, Shepherd-Themistocleous, Claire, Thea, Alessandro, Tomalin, Ian R, Williams, Thomas, Womersley, William John, Worm, Steven, Baber, Mark, Bainbridge, Robert, Hörmann, Natascha, Custódio, Analu, Buchmuller, Oliver, Bundock, Aaron, Burton, Darren, Casasso, Stefano, Citron, Matthew, Colling, David, Corpe, Louie, Cripps, Nicholas, Dauncey, Paul, Davies, Gavin, Da Costa, Eliza Melo, De Wit, Adinda, Della Negra, Michel, Dunne, Patrick, Elwood, Adam, Ferguson, William, Fulcher, Jonathan, Futyan, David, Hall, Geoffrey, Iles, Gregory, Kenzie, Matthew, De Jesus Damiao, Dilson, Lane, Rebecca, Lucas, Robyn, Lyons, Louis, Magnan, Anne-Marie, Malik, Sarah, Nash, Jordan, Nikitenko, Alexander, Pela, Joao, Pesaresi, Mark, Petridis, 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Esposito, Marco, Fabozzi, Francesco, Iorio, Alberto Orso Maria, Lanza, Giuseppe, Lista, Luca, Meola, Sabino, Merola, Mario, Seva, Tomislav, Paolucci, Pierluigi, Sciacca, Crisostomo, Thyssen, Filip, Azzi, Patrizia, Bacchetta, Nicola, Benato, Lisa, Bisello, Dario, Boletti, Alessio, Branca, Antonio, Carlin, Roberto, Vander Velde, Catherine, Carvalho Antunes De Oliveira, Alexandra, Checchia, Paolo, Dall'Osso, Martino, Dorigo, Tommaso, Dosselli, Umberto, Gasparini, Fabrizio, Gasparini, Ugo, Gozzelino, Andrea, Kanishchev, Konstantin, Lacaprara, Stefano, Vanlaer, Pascal, Margoni, Martino, Meneguzzo, Anna Teresa, Pazzini, Jacopo, Pozzobon, Nicola, Ronchese, Paolo, Simonetto, Franco, Torassa, Ezio, Tosi, Mia, Zanetti, Marco, Zotto, Pierluigi, Yonamine, Ryo, Zucchetta, Alberto, Zumerle, Gianni, Braghieri, Alessandro, Magnani, Alice, Montagna, Paolo, Ratti, Sergio P, Re, Valerio, Riccardi, Cristina, Salvini, Paola, Vai, Ilaria, Zenoni, Florian, Vitulo, Paolo, Alunni Solestizi, Luisa, Biasini, Maurizio, Bilei, Gian Mario, Ciangottini, Diego, Fanò, Livio, Lariccia, Paolo, Mantovani, Giancarlo, Menichelli, Mauro, Saha, Anirban, Zhang, Fengwangdong, Santocchia, Attilio, Androsov, Konstantin, Azzurri, Paolo, Bagliesi, Giuseppe, Bernardini, Jacopo, Boccali, Tommaso, Castaldi, Rino, Ciocci, Maria Agnese, Dell'Orso, Roberto, Donato, Silvio, Beernaert, Kelly, Fedi, Giacomo, Foà, Lorenzo, Giassi, Alessandro, Grippo, Maria Teresa, Ligabue, Franco, Lomtadze, Teimuraz, Martini, Luca, Messineo, Alberto, Palla, Fabrizio, Rizzi, Andrea, Erö, Janos, Benucci, Leonardo, Savoy-Navarro, Aurore, Serban, Alin Titus, Spagnolo, Paolo, Tenchini, Roberto, Tonelli, Guido, Venturi, Andrea, Verdini, Piero Giorgio, Barone, Luciano, Cavallari, Francesca, D'imperio, Giulia, Cimmino, Anna, Del Re, Daniele, Diemoz, Marcella, Gelli, Simone, Jorda, Clara, Longo, Egidio, Margaroli, Fabrizio, Meridiani, Paolo, Organtini, Giovanni, Paramatti, Riccardo, Preiato, Federico, Crucy, Shannon, Rahatlou, Shahram, Rovelli, Chiara, Santanastasio, Francesco, Traczyk, Piotr, Amapane, Nicola, Arcidiacono, Roberta, Argiro, Stefano, Arneodo, Michele, Bellan, Riccardo, Biino, Cristina, Dobur, Didar, Cartiglia, Nicolo, Costa, Marco, Covarelli, Roberto, Degano, Alessandro, Demaria, Natale, Finco, Linda, Kiani, Bilal, Mariotti, Chiara, Maselli, Silvia, Migliore, Ernesto, Fagot, Alexis, Monaco, Vincenzo, Monteil, Ennio, Obertino, Maria Margherita, Pacher, Luca, Pastrone, Nadia, Pelliccioni, Mario, Pinna Angioni, Gian Luca, Ravera, Fabio, Romero, Alessandra, Ruspa, Marta, Garcia, Guillaume, Sacchi, Roberto, Solano, Ada, Staiano, Amedeo, Tamponi, Umberto, Belforte, Stefano, Candelise, Vieri, Casarsa, Massimo, Cossutti, Fabio, Della Ricca, Giuseppe, Gobbo, Benigno, Gul, Muhammad, La Licata, Chiara, Marone, Matteo, Schizzi, Andrea, Zanetti, Anna, Kropivnitskaya, Anna, Nam, Soon-Kwon, Kim, Dong Hee, Kim, Gui Nyun, Kim, Min Suk, Kong, Dae Jung, Mccartin, Joseph, Lee, Sangeun, Oh, Young Do, Sakharov, Alexandre, Son, Dong-Chul, Brochero Cifuentes, Javier Andres, Kim, Hyunsoo, Kim, Tae Jeong, Song, Sanghyeon, Choi, Suyong, Go, Yeonju, Ocampo Rios, Alberto Andres, Gyun, Dooyeon, Hong, Byung-Sik, Jo, Mihee, Kim, Hyunchul, Kim, Yongsun, Lee, Byounghoon, Lee, Kisoo, Lee, Kyong Sei, Lee, Songkyo, Park, Sung Keun, Poyraz, Deniz, Roh, Youn, Yoo, Hwi Dong, Choi, Minkyoo, Kim, Hyunyong, Kim, Ji Hyun, Lee, Jason Sang Hun, Park, Inkyu, Ryu, Geonmo, Ryu, Min Sang, and Choi, Young-Il

Subjects
little Higgs model, scattering [p p], structure, 2 [bottom], composite [Higgs model], 8000 GeV-cms, search for [W'], flavor, associated production [W], massive [resonance], CMS, upper limit [channel cross section], High Energy Physics::Phenomenology, triplet [model], bottom [jet], leptonic decay [W], pair production [bottom], CERN LHC Coll, missing-energy [transverse energy], hadronic decay [Higgs particle], hadroproduction [Higgs particle], particle identification [bottom], High Energy Physics::Experiment, colliding beams [p p], narrow resonance, mass: lower limit [W'], Particle Physics - Experiment, experimental results
Abstract

A search for a massive resonance W' decaying into a W and a Higgs boson in the l nu b anti-b (l = e, mu) final state is presented. Results are based on data corresponding to an integrated luminosity of 19.7 inverse femtobarns of proton-proton collisions at sqrt(s)=8 TeV, collected using the CMS detector at the LHC. For a high-mass (>~1 TeV) resonance, the two bottom quarks coming from the Higgs boson decay are reconstructed as a single jet, which can be tagged by placing requirements on its substructure and flavour. Exclusion limits at 95% confidence level are set on the production cross section of a narrow resonance decaying into WH, as a function of its mass. In the context of a little Higgs model, a lower limit on the W' mass of 1.4 TeV is set. In a heavy vector triplet model that mimics the properties of composite Higgs models, a lower limit on the W' mass of 1.5 TeV is set. In the context of this model, the results are combined with related searches to obtain a lower limit on the W' mass of 1.8 TeV, the most restrictive to date for decays to a pair of standard model bosons. A search for a massive resonance ${\mathrm{W}^{\prime }}$ decaying into a W and a Higgs boson in the $\ell \nu \mathrm{b} \overline{\mathrm{b}} $ ( $\ell = \mathrm {e}$ , $\mu $ ) final state is presented. Results are based on data corresponding to an integrated luminosity of 19.7 $\,\text {fb}^{{-1}}$ of proton–proton collisions at $\sqrt{s}=8$ $~\text {TeV}$ , collected using the CMS detector at the LHC. For a high-mass ( $\gtrsim $ 1 $~\text {TeV}$ ) resonance, the two bottom quarks coming from the Higgs boson decay are reconstructed as a single jet, which can be tagged by placing requirements on its substructure and flavour. Exclusion limits at 95 % confidence level are set on the production cross section of a narrow resonance decaying into WH, as a function of its mass. In the context of a little Higgs model, a lower limit on the ${\mathrm{W}^{\prime }}$ mass of 1.4 $~\text {TeV}$ is set. In a heavy vector triplet model that mimics the properties of composite Higgs models, a lower limit on the ${\mathrm{W}^{\prime }}$ mass of 1.5 $~\text {TeV}$ is set. In the context of this model, the results are combined with related searches to obtain a lower limit on the ${\mathrm{W}^{\prime }}$ mass of 1.8 $~\text {TeV}$ , the most restrictive to date for decays to a pair of standard model bosons. A search for a massive resonance W' decaying into a W and a Higgs boson in the l nu b anti-b (l = e, mu) final state is presented. Results are based on data corresponding to an integrated luminosity of 19.7 inverse femtobarns of proton-proton collisions at sqrt(s) = 8 TeV, collected using the CMS detector at the LHC. For a high-mass ( greater than 1 TeV) resonance, the two bottom quarks coming from the Higgs boson decay are reconstructed as a single jet, which can be tagged by placing requirements on its substructure and flavour. Exclusion limits at 95% confidence level are set on the production cross section of a narrow resonance decaying into WH, as a function of its mass. In the context of a little Higgs model, a lower limit on the W' mass of 1.4 TeV is set. In a heavy vector triplet model that mimics the properties of composite Higgs models, a lower limit on the W' mass of 1.5 TeV is set. In the context of this model, the results are combined with related searches to obtain a lower limit on the W' mass of 1.8 TeV, the most restrictive to date for decays to a pair of standard model bosons.

Published
2016

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