14 results on '"Keil, Silvia"'
Search Results
2. The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells
- Author
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Stricker, Helena M., Rommerswinkel, Nadine, Keil, Silvia, Gnoth, Sandina A., Niggemann, Bernd, and Dittmar, Thomas
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- 2021
- Full Text
- View/download PDF
3. Comparison of hybrid clones derived from human breast epithelial cells and three different cancer cell lines regarding in vitro cancer stem/ initiating cell properties
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Fahlbusch, Sera Selina, Keil, Silvia, Epplen, Jörg T., Zänker, Kurt S., and Dittmar, Thomas
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- 2020
- Full Text
- View/download PDF
4. Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and Aneuploidy
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Dörnen, Jessica, primary, Sieler, Mareike, additional, Weiler, Julian, additional, Keil, Silvia, additional, and Dittmar, Thomas, additional
- Published
- 2020
- Full Text
- View/download PDF
5. Hybrid clone cells derived from human breast epithelial cells and human breast cancer cells exhibit properties of cancer stem/initiating cells
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Gauck, Daria, primary, Keil, Silvia, additional, Niggemann, Bernd, additional, Zänker, Kurt S., additional, and Dittmar, Thomas, additional
- Published
- 2017
- Full Text
- View/download PDF
6. Lipopolysaccharide (LPS) Promotes Apoptosis in Human Breast Epithelial × Breast Cancer Hybrids, but Not in Parental Cells
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Fried, Sabrina, primary, Tosun, Songuel, additional, Troost, Gabriele, additional, Keil, Silvia, additional, Zaenker, Kurt S., additional, and Dittmar, Thomas, additional
- Published
- 2016
- Full Text
- View/download PDF
7. Crescimento e Nutrição de Ocotea odorifera (Canela Sassafrás) Submetido à Fertilização e à Omissão de Nutrientes
- Author
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Keil, Silvia Schmidlin, Reissmann, Carlos Bruno, and Pellico Netto, Sylvio
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Ocotea odorifera ,fertilization ,nutrient omission ,fertilização ,omissão de nutriente - Abstract
The present paper has as objective the evaluation of the nutritional aspects, fertilization effect and omission of nutrients in the plants grow of canela sassafras (Ocotea odorifera (Vell.) Rohwer), in a vegetation house for 24 months, consisting of 11 treatments and five repetitions, with seasonal collections, using the springer material. The treatments consisted of control (natural soil), complete fertilization (N, P, K, Ca, Mg, S, Zn and B), fertilization with individual nutrients omission (-N, -P, -K, -Ca, -Mg, -S, -B, -Zn) and organic fertilization (bovine manure). Natural fertility soil and plants of canela sassafras originally from natural regeneration dispossess in causality statistical delineation were utilized. The height, diameter length and biomass were evaluated. To the development in height of the canela sassafras, the more limited nutrient were sulphur and to the diameter length was the fertilization with macro and micronutrients, but there was no significant difference between the treatments. The roots dry mass reduced when used macro and micronutrients fertilization, and the dry mass of the aerial part with the omission of N and P. The organic fertilization demonstrated to be efficient, so much for the increment in height, as for the production of foliar mass. doi: 10.4336/2009.pfb.58.17 Avaliaram-se os aspectos nutricionais e o efeito da fertilização e da omissão de nutrientes no desenvolvimento de plântulas de canela sassafrás (Ocotea odorifera (Vell.) Rohwer), conduzido em casa de vegetação durante 24 meses, constando de 11 tratamentos e cinco repetições, com coletas sazonais, sendo utilizado o material obtido na primavera. Os tratamentos consistiram de controle (solo natural), adubação completa (N, P, K, Ca, Mg, S, Zn, B), adubação com omissão individual de nutrientes (-N, -P, -K, -Ca, -Mg, -S, -B, -Zn) e tratamento com adubação orgânica (esterco bovino curtido). Foram utilizados vasos com solo de baixa fertilidade natural e plântulas de canela sassafrás oriundas de regeneração natural dispostos em delineamento estatístico inteiramente casualizado. Foram avaliados desenvolvimento em altura, diâmetro do colo e biomassa. Para o crescimento em altura da canela sassafrás, o nutriente mais limitante foi o enxofre, e para o diâmetro do colo foi a fertilização com macro e micronutrientes, embora não tenha havido diferença significativa entre os tratamentos. A massa seca radicular foi reduzida quando da fertilização com macro e micronutrientes e a massa seca aérea quando se omitiu N e P. A adubação orgânica demonstrou ser eficiente, tanto para o incremento em altura, quanto para a produção de massa foliar. doi: 10.4336/2009.pfb.58.17
- Published
- 2010
8. Crescimento, nutrição e composição do óleo essencial de sassafrás submetido à fertilização e à omissão de nutrientes
- Author
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Keil, Silvia Schmidlin, Pellico Netto, Sylvio, 1941, Universidade Federal do Paraná. Setor de Ciências Agrárias. Programa de Pós-Graduação em Engenharia Florestal, and Reissmann, Carlos Bruno
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Recursos florestais e engenharia florestal ,Essencias e oleos essenciais ,Plantas - Nutrição ,Sassafrás - Nutrição ,Plantas - Fertilização ,Oleo de sassafras ,Fertilidade do solo - Abstract
Orientador: Carlos Bruno Reissmann Coorientador: Sylvio Pellico Neto Inclui apêndice Tese (doutorado) - Universidade Federal do Paraná, Setor de Ciências Agrárias, Programa de Pós-Graduação em Engenharia Florestal. Defesa: Curitiba, 26/10/2007 Inclui bibliografia Área de concentração: Silvicultura
- Published
- 2007
9. Staatsangehörigkeit, nationale Identität und Fremdenfeindlichkeit : Deutschland, Frankreich und Großbritannien im empirischen Vergleich
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Keil, Silvia and Institut für Politikwissenschaften
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citizenship ,xenophobia ,nationale Identität ,Germany ,ddc:320 ,Fremdenfeindlichkeit ,Frankreich ,national identity ,Great Britain ,Staatsangehörigkeit ,Deutschland ,Political science - Abstract
In jeder westlichen Demokratie gibt es Bevölkerungsgruppen, die fremdenfeindliche Einstellungsmuster aufweisen. Diese Einstellungsmuster basieren auf Ideologien der Ungleichheit und widersprechen daher dem demokratischen Gleichheitsprinzip und gefährden den sozialen Frieden. Sozialpsychologische wie soziologische Theorieansätze zur Erklärung fremdenfeindlicher Einstellungen richten den Fokus zumeist auf das Individuum und vernachlässigen gesamtgesellschaftliche wie politische Entwicklungen sowie die politischen Rahmenbedingungen, die das Zusammenleben zwischen unterschiedlichen Bevölkerungsgruppen regeln. Das Bedürfnis des Individuums, nach einem positiven Selbstkonzept sowie nach Orientierung im Zeitalter der Globalisierung wird als Ausgangspunkt für die Ethnisierung gesellschaftlicher Konflikte um Anerkennung und Ressourcen betrachtet. In diesen Erklärungsansätzen vernachlässigt wird der Einfluss politischer und institutioneller Rahmenbedingungen. Der Konzeption des demokratischen Nationalstaates inhärent ist jedoch die juristische wie politische Unterscheidung zwischen Bürgern und Ausländern. In dieser Unterscheidung wird dem Staatsvolk eine positive kollektive Identität als Träger demokratischer Herrschaft zugeschrieben. Sind die juristischen Regelungen der nationalen Zugehörigkeit, wie in der Bundesrepublik Deutschland, ethnisch konnotiert, dann spielen ethnische Merkmale auch für die gesellschaftliche Definition von sog. Fremdgruppen eine zentrale Rolle. Eine zentrale Grundannahme meines Dissertationsprojektes ist, dass es einen spezifischen Zusammenhang zwischen der staatlich-institutionellen Definition und der politischen Konstruktion nationaler Identität gibt und dass sich dies auch in den Einstellungsmustern der Bevölkerung widerspiegelt. In der Bundesrepublik Deutschland wurde bis zur Staatsangehörigkeitsrechtsreform 2000 Ausländern aus einem anderen Kulturkreis die deutsche Staatsangehörigkeit generationenübergreifend nur erschwert gewährt. Mit der Staatsangehörigkeit verbunden sind Rechte und Pflichten. Kennzeichnend für Deutschland ist, dass ethnische Minderheiten in der Regel Ausländer sind und nicht über zentrale politische Partizipationsmöglichkeiten wie das passive und aktive Wahlrecht auf Landes- und Bundesebene verfügen. So sind sie keine gleichwertigen Mitglieder im Diskurs über nationale Identität. Ethnische Merkmale für die Definition von Gruppenzugehörigkeiten spielen so eine bedeutende Rolle. Gesellschaftliche Konflikte um materielle Ressourcen werden so verstärkt als Konflikte zwischen ethnischen Gruppen interpretiert. Die Entstehung fremdenfeindlicher Einstellungsmuster ist damit nicht unabhängig von der politischen und juristisch-institutionellen Definition des Staatsvolkes. Ziel des Dissertationsprojektes ist es, die Verbindung zwischen institutionellen und politischen Rahmenbedingungen einerseits und der Ebene der individuellen Einstellungen andererseits herzustellen. Des Weiteren gilt es, den Einfluss der juristisch-institutionellen und politischen Bedingungen für die Entstehung fremdenfeindlicher Einstellungen offen zu legen. Der interkulturelle Vergleich dieser Bedingungen unter Einbeziehung Frankreichs und Großbritanniens soll die Zusammenhänge genauer klären. Die Entstehung fremdenfeindlicher Einstellungsmuster in der Bevölkerung - so die These - ist nicht unabhängig von der politischen Konstruktion sowie der staatlich-institutionellen Definition nationaler Identität. So gerät der demokratische Nationalstaat in die Pflicht, institutionelle Rahmenbedingungen zu überdenken, um der Entstehung fremdenfeindlicher Einstellungsmuster entgegenzuwirken. Das Dissertationsprojekt wird mögliche Perspektiven aufzeigen. Angesichts des fortschreitenden europäischen Integrationsprozesses wird die Frage nach einer möglichen europäischen Identität zunehmend an Bedeutung gewinnen. Der Kampf gegen fremdenfeindliche Einstellungsmuster ist so nicht nur ein nationaler, sondern auch zunehmend ein europäischer. In every western democracy, there are sections of the population showing hostility towards immigrants and ethnic minorities. These attitudes are based upon ideologies of inequality and are contrary to the ideals of the democratic constitution. They also affect the relationship between different ethnic groups in society. Sociological and socio psychological theoretical approaches dealing with xenophobia generally focus on the individual and almost completely ignore the role of constitutional and political conditions. Individual needs for a positive self-concept are regarded as a starting point for social conflicts about ethnic and national recognition and about material resources. However, the conception of the democratic nation state is based upon the political and institutional differentiation between citizens and non-citizens. In this context, a positive collective identity is ascribed to the citizens as bearers of democracy. If the rules and regulations of belonging are linked to ethnicity - as in Germany - then ethnic indications become important for the definition of the out-group. This sense of not belonging is linked to the notion of citizenship. One of the main assumptions of my PhD-project is the fact that there is a specific connection between the institutional definition and political construction of national identity and that this relation is also reflected by attitudes towards immigrants and ethnic minorities in society. Up until the reform of nationality-law in 2000, gaining citizenship was extremely difficult for immigrants with a different cultural background. Even the children and grandchildren of immigrants were mostly excluded from becoming German citizens. Citizenship is connected with the granting of rights and duties. One characteristic of Germany is the fact that members of ethnic minorities are generally non-citizens and, as a result, they do not have the right to vote in central elections. Thus, they are excluded from the political discourse about national identity. Consequently, the ethnic background is essential for defining group identity. Social conflicts about economic resources and national identity tend to be interpreted as conflicts between ethnic groups. The disadvantages of non-citizenship include limited means of fighting against discrimination. The development of hostile attitudes towards foreigners is determined by the political and institutional definition of citizenship. On the one hand, the PhD-project focuses on the connection between the institutional and the political definition of belonging to the nation and, on the other hand, it tries to explain the development of hostile attitudes against foreigners. By including an intercultural approach between Germany, France and Great Britain, I will discuss the role of the institutional and political framework in creating xenophobic attitudes. Democratic nations have the duty to fight against antidemocratic ways of thinking. If the institutional and political definition of national identity influences attitudes against foreigners and ethnic minorities - which I think is the case - then political leaders have to prevent this by changing institutional and political general conditions. Considering the ongoing of the European integration, the struggle against xenophobia is no longer only a national affair, but has developed into an all-European concern.
- Published
- 2006
10. Labor migration, market competition and ethnocentrism: guest workers in Israel and Germany ; Ergebnisse eines Forschungsprojektes und Beschreibung des Datensatzes (ZA-Studien-Nr. 3974)
- Author
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Iser, Julia and Keil, Silvia
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labor migration ,Theorieanwendung ,ethnische Gruppe ,value-orientation ,Federal Republic of Germany ,Wertorientierung ,internationaler Vergleich ,migration ,documentation ,theory application ,ethnic group ,Einstellung ,empirisch-quantitativ ,Dokumentation ,Israel ,Migration, Sociology of Migration ,Arbeitsmigration ,Social sciences, sociology, anthropology ,Gesellschaft ,quantitative empirical ,Sozialwissenschaften, Soziologie ,Ausländer ,empirisch ,international comparison ,ausländischer Arbeitnehmer ,alien ,Migrationsforschung ,prejudice ,Diskriminierung ,Bundesrepublik Deutschland ,society ,attitude ,impact ,Auswirkung ,ddc:300 ,foreign worker ,migration research ,Vorurteil ,empirical ,discrimination - Abstract
'The major objective of the research was to examine attitudes and values toward guest workers in Israel and Germany in a comparative perspective. The main objects of examinations are the social conditions which shape the normative system of beliefs, attitudes, stereotypes, prejudice and behaviour toward foreign workers and ethnic minorities. The research was cast within theoretical frameworks that focus on the emergence of prejudice, discrimination and ethnic antagonism in modern societies. Two alternative, but by no means contradictory, models were used. The first is social psychological and centres on such concepts as social distance, prejudice, authoritarianism, and ethnocentrism. The second approach focuses on group competition over resources and rewards in national markets. Data to test the hypotheses were taken from national representative samples of adult citizens in Israel and Germany, respectively. The data was analysed using a variety of multivariate statistical models. It was our aim to contribute to a better understanding of the Israeli and German societies and to the theoretical knowledge regarding the social conditions that affect the system of values, attitudes, and behaviour toward migrant workers and ethnic minorities in modern societies. The comparison between Germany and Israel was one special point of interest, because Germany has been employing guest workers for more than a quarter of a century whereas Israel only recently began to rely on foreign workers. The influence of guest worker communities on contemporary societies is one significant social and economic problem of modern states. The study tried to increase the understanding of these mechanisms and phenomena.' (author's abstract)
- Published
- 2004
11. Labor migration, market competition and ethnocentrism: guest workers in Israel and Germany ; Ergebnisse eines Forschungsprojektes und Beschreibung des Datensatzes (ZA-Studien-Nr. 3974)
- Author
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Iser, Julia, Keil, Silvia, Iser, Julia, and Keil, Silvia
- Abstract
'The major objective of the research was to examine attitudes and values toward guest workers in Israel and Germany in a comparative perspective. The main objects of examinations are the social conditions which shape the normative system of beliefs, attitudes, stereotypes, prejudice and behaviour toward foreign workers and ethnic minorities. The research was cast within theoretical frameworks that focus on the emergence of prejudice, discrimination and ethnic antagonism in modern societies. Two alternative, but by no means contradictory, models were used. The first is social psychological and centres on such concepts as social distance, prejudice, authoritarianism, and ethnocentrism. The second approach focuses on group competition over resources and rewards in national markets. Data to test the hypotheses were taken from national representative samples of adult citizens in Israel and Germany, respectively. The data was analysed using a variety of multivariate statistical models. It was our aim to contribute to a better understanding of the Israeli and German societies and to the theoretical knowledge regarding the social conditions that affect the system of values, attitudes, and behaviour toward migrant workers and ethnic minorities in modern societies. The comparison between Germany and Israel was one special point of interest, because Germany has been employing guest workers for more than a quarter of a century whereas Israel only recently began to rely on foreign workers. The influence of guest worker communities on contemporary societies is one significant social and economic problem of modern states. The study tried to increase the understanding of these mechanisms and phenomena.' (author's abstract)
- Published
- 2010
12. Fusion of CCL21 Non-Migratory Active Breast Epithelial and Breast Cancer Cells Give Rise to CCL21 Migratory Active Tumor Hybrid Cell Lines
- Author
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Berndt, Benjamin, primary, Haverkampf, Sonja, additional, Reith, Georg, additional, Keil, Silvia, additional, Niggemann, Bernd, additional, Zänker, Kurt S., additional, and Dittmar, Thomas, additional
- Published
- 2013
- Full Text
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13. Propriedades físicas do solo e desenvolvimento da Araucaria angustifolia (Bert.)O. Ktze
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Keil, Silvia Schmidlin, 1960, Universidade Federal do Paraná. Setor de Ciências Agrárias. Programa de Pós-Graduação em Ciência do Solo, and Souza, Marcos Luiz de Paula, 1947
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Araucaria angustifólia ,Teses ,Fisica do solo - Abstract
Orientador: Marcos Luiz de Paula Souza Dissertaçao (mestrado) -Universidade Federal do Paraná. Curso de Pós-Graduaçao em Agronomia / Ciencia do Solo Inclui bibliografia Acervo transferido da AG para CF 2001 Resumo: O trabalho objetivou a determinação da influência das características físicas e armazenarnento de água no crescimento da Araucar'ia angustifolia, no 29 Planalto Paranaense, em quatro unidades de solo: dois Litõlicos (Re-5, Re-4); um Cambissolo (Ca-7) e um Pozólico Vermelho Amarelho (PVa-5). Os resultados mostraram que o melhor desenvolvimento seguiu a seqüência Pva-5 > Ca-7 > Re-5 > Re-4, devido às condições físicas (porosidade total e aeração), e às condições climáticas e topográficas dos solos estudados. As unidades de solo foram caracterizadas quanto às suas propriedades físicas (granulométrica, densidade do solo e partículas, macro e microporosidade, e retenção de água às energias de -60 cm, -344 cm e-15.495 cm de coluna de água) além de ter sido medido, durante o período de um ano, o armazenamento de água e a porosidade de aeração até a profundidade de 125 cm. Os dados obtidos foram comparados ao crescimento em altura dos povoamentos de Araucaria com 15 anos de idade (índice de sítio). Os resultados evidenciaram a importancia das propriedades físicas no crescimento da espécie em especial da porodidade de aeração e profundidade, bem como a topografia dos solos. Abstract: The present study determined the influence of soil physical characteristics and water retention on the growth of Araucaria angustifolia. The study site was located on the 2nd Plateau of the State of Parana and included for soil units: two Litolic soils (Re-5, Re-4) one Cambisol (Ca-7) and one Red-Yellow Podzolic Soil(PVa-5) .The results demonstrate better development on the soil units PVA and Ca-1. The ranking in development was PVa-5> Ca-7 > Re-5 > Re-4 due to soil physical conditions (total porosity and aeration), and climatic and topographic conditions of the study site. The soil units were characterized in their physical aspects (particle size distribution, bulk and particle densities, macro and microporosity, and water retention of -60, -344, -15.495 cm H 20. Water storage and aeration porosity was monitored during one year to a depth up to 125 cm, depending on the soil unit. The datas were compared to tree heights of a 15-year old plantation (site index). The results are an evidence of the importance of soil physical characteristics on the growth of the species, specially of the aeration porosity, as well as soil depth and its landscape position.
- Published
- 1989
14. Cell fusion: the origin of cancer stem cells?
- Author
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Schwitalla, Sarah, Keil, Silvia, Zänker, Kurt S., and Dittmar, Thomas
- Subjects
CELL fusion ,HOMEOSTASIS ,STEM cells ,TUMORS ,CANCER cells ,CANCER treatment ,CELL lines ,CELL cycle - Abstract
Cell fusion is a cell-biological phenomenon, which was originally described as an event of development and homeostasis. Moreover, recent discoveries give rise to the theory that fusion events between stem cells and tumor cells could act as malignant and crucial originators in cancer stem cell (CSC) generation, besides other theories such as CSCs deriving from tissue stem cells that have accumulated genetic aberrations or CSCs deriving from differentiated progenitor cells that have regained self- renewing capacity. By now CSCs are known as cancer-initiating cells with characteristic features of stem cells, such as self-renewing, differentiation, regeneration of tissues at low cell numbers and drug resistance. This rare population of cancer-initiating cells attracts attention as a target in cancer therapies and, therefore, there is an urgent need for further investigation on CSCs is present. After 24 h co-cultivation of M13SV1 enhanced green fluorescent protein (EGFP)-neo breast stem cells and invasive HS578T-Hyg breast cancer cells under selective conditions, cell clones that emerged from spontaneous fusion events were isolated and cultivated separately. Short tandem repeat analysis of hybrid cells showed an overlap of the parental alleles, indicating that hybrid cells have been originated from real cell fusion events. Despite some varieties concerning the data of the further hybrid cell characterization due to different genetic profile among them, one can detect clear tendencies of similarity between all hybrid cell lines compared with their parental cell lines. XTT-proliferation assays, for example, show a significantly higher proliferation rate of the hybrid cell lines compared with their parental cell lines. Dependent on the hybrid cell line a 5-10-times higher proliferation rate could be detected in comparison with the breast stem cell line M13SV1 EGFP-neo, whereas, in contrast to the breast cancer cell line HS578T Hyg, the proliferation shows an up to four-times higher rate. Moreover, expression pattern analysis by real-time PCR data revealed interesting results in multiple up- and down-regulation of cancer and drug metabolism genes compared with the HS578T cell line and the M13SV1 cell line, for example, upregulation of cell cycle regulators as p16 and p53 in all hybrids, drug resistance transporters as ABCC6, ABCB1 and major vault protein (MVP) in all hybrid cell lines as well as upregulation of androgen receptor in three of four hybrid cell lines, which stands in a reciprocal relationship to downregulation of estrogen receptor in some poor prognosis breast cancers, probably indicating that fusion might cause a switch to an estrogen-independent tumor growth. The real-time PCR data have been confirmed by Western blot analysis. On the basis of spontaneous fusion between M13SV1 breast stem cells and invasive HS578T breast cancer cells we could give a promising insight into characterization of fusion cells as a possible model for CSCs. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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