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22 results on '"Kawano, Mahiru"'

6. The role of myeloid-derived suppressor cells in endometrial cancer displaying systemic inflammatory response: clinical and preclinical investigations

Author

Yokoi, Eriko, primary, Mabuchi, Seiji, additional, Komura, Naoko, additional, Shimura, Kotaro, additional, Kuroda, Hiromasa, additional, Kozasa, Katsumi, additional, Takahashi, Ryoko, additional, Sasano, Tomoyuki, additional, Kawano, Mahiru, additional, Matsumoto, Yuri, additional, Kodama, Michiko, additional, Hashimoto, Kae, additional, Sawada, Kenjiro, additional, and Kimura, Tadashi, additional

Published
2019
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8. Estrogen stimulates female cancer progression by inducing myeloid-derived suppressive cells: investigations on pregnant and non-pregnant experimental models

Author

Kozasa, Katsumi, primary, Mabuchi, Seiji, additional, Matsumoto, Yuri, additional, Kuroda, Hiromasa, additional, Yokoi, Eriko, additional, Komura, Naoko, additional, Kawano, Mahiru, additional, Takahashi, Ryoko, additional, Sasano, Tomoyuki, additional, Shimura, Kotaro, additional, Kodama, Michiko, additional, Hashimoto, Kae, additional, Sawada, Kenjiro, additional, Nagasaka, Kazunori, additional, and Kimura, Tadashi, additional

Published
2019
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9. Prostaglandin E2 produced by myeloid-derived suppressive cells induces cancer stem cells in uterine cervical cancer

Author

Kuroda, Hiromasa, primary, Mabuchi, Seiji, additional, Yokoi, Eriko, additional, Komura, Naoko, additional, Kozasa, Katsumi, additional, Matsumoto, Yuri, additional, Kawano, Mahiru, additional, Takahashi, Ryoko, additional, Sasano, Tomoyuki, additional, Shimura, Kotaro, additional, Kodama, Michiko, additional, Hashimoto, Kae, additional, Sawada, Kenjiro, additional, Morii, Eiichi, additional, and Kimura, Tadashi, additional

Published
2018
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12. The Highly Metastatic Nature of Uterine Cervical/Endometrial Cancer Displaying Tumor-Related Leukocytosis: Clinical and Preclinical Investigations

Author

Sasano, Tomoyuki, primary, Mabuchi, Seiji, additional, Kozasa, Katsumi, additional, Kuroda, Hiromasa, additional, Kawano, Mahiru, additional, Takahashi, Ryoko, additional, Komura, Naoko, additional, Yokoi, Eriko, additional, Matsumoto, Yuri, additional, Hashimoto, Kae, additional, Sawada, Kenjiro, additional, Morii, Eiichi, additional, and Kimura, Tadashi, additional

Published
2018
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14. Comparison of clinical utilities of the platelet count and platelet-lymphocyte ratio for predicting survival in patients with cervical cancer: a single institutional study and literature review

Author

Kozasa, Katsumi, primary, Mabuchi, Seiji, additional, Komura, Naoko, additional, Yokoi, Eriko, additional, Hiromasa, Kuroda, additional, Sasano, Tomoyuki, additional, Kawano, Mahiru, additional, Matsumoto, Yuri, additional, Kobayashi, Eiji, additional, and Kimura, Tadashi, additional

Published
2017
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15. Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary

Author

Takahashi, Ryoko, primary, Mabuchi, Seiji, additional, Kawano, Mahiru, additional, Sasano, Tomoyuki, additional, Matsumoto, Yuri, additional, Kuroda, Hiromasa, additional, Kozasa, Katsumi, additional, Hashimoto, Kae, additional, Sawada, Kenjiro, additional, and Kimura, Tadashi, additional

Published
2016
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16. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer

Author

Kawano, Mahiru, primary, Mabuchi, Seiji, additional, Matsumoto, Yuri, additional, Sasano, Tomoyuki, additional, Takahashi, Ryoko, additional, Kuroda, Hiromasa, additional, Kozasa, Katsumi, additional, Hashimoto, Kae, additional, Isobe, Aki, additional, Sawada, Kenjiro, additional, Hamasaki, Toshimitsu, additional, Morii, Eiichi, additional, and Kimura, Tadashi, additional

Published
2015
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18. Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary

Author

Sasano, Tomoyuki, primary, Mabuchi, Seiji, additional, Kuroda, Hiromasa, additional, Kawano, Mahiru, additional, Matsumoto, Yuri, additional, Takahashi, Ryoko, additional, Hisamatsu, Takeshi, additional, Sawada, Kenjiro, additional, Hashimoto, Kae, additional, Isobe, Aki, additional, Testa, Joseph R., additional, and Kimura, Tadashi, additional

Published
2014
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21. Abstract 378: The significance of vascular endothelial growth factor C in the lymphangiogenesis and lymph node metastasis of ovarian cancer.

Author

Hisamatsu, Takeshi, primary, Mabuchi, Seiji, additional, Sasano, Tomoyuki, additional, Takahashi, Ryoko, additional, Kawano, Mahiru, additional, Matsumoto, Yuri, additional, Hashimoto, Kae, additional, Isobe, Aki, additional, Sawada, Kenjiro, additional, Morishige, Kenichiro, additional, and Kimura, Tadashi, additional

Published
2013
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22. Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary.

Author

Sasano T, Mabuchi S, Kuroda H, Kawano M, Matsumoto Y, Takahashi R, Hisamatsu T, Sawada K, Hashimoto K, Isobe A, Testa JR, and Kimura T

Subjects
Animals, Antineoplastic Agents administration & dosage, Antineoplastic Agents pharmacology, Cell Line, Tumor, Cisplatin administration & dosage, Cisplatin pharmacology, Drug Resistance, Neoplasm drug effects, Drug Synergism, Female, Humans, Mechanistic Target of Rapamycin Complex 1, Mice, Multiprotein Complexes metabolism, Phosphorylcholine administration & dosage, Phosphorylcholine pharmacology, Signal Transduction drug effects, TOR Serine-Threonine Kinases metabolism, Xenograft Model Antitumor Assays, Adenocarcinoma, Clear Cell drug therapy, Adenocarcinoma, Clear Cell metabolism, Ovarian Neoplasms drug therapy, Ovarian Neoplasms metabolism, Phosphorylcholine analogs & derivatives, Proto-Oncogene Proteins c-akt metabolism
Abstract

Unlabelled: The aim of this study was to determine the role of AKT as a therapeutic target in ovarian clear cell carcinoma (CCC), an aggressive, chemoresistant histologic subtype of ovarian cancer. AKT activation was assessed by immunohistochemistry (IHC) using human tissue microarrays of primary ovarian cancers, composed of both CCC and serous adenocarcinoma (SAC). The growth-inhibitory effect of AKT-specific targeting by the small-molecule inhibitor, perifosine, was examined using ovarian CCC cell lines in vitro and in vivo. Finally, the activity of perifosine was examined using in CCC-derived tumors that had acquired resistance to anti-VEGF or chemotherapeutics such as bevacizumab or cisplatin, respectively. Interestingly, AKT was frequently activated both in early-stage and advanced-stage CCCs. Treatment of CCC cells with perifosine attenuated the activity of AKT-mTORC1 signaling, inhibited proliferation, and induced apoptosis. The effect of perifosine was more profound under conditions of high AKT activity compared with low AKT activity. Increased AKT activation and enhanced sensitivity to perifosine were observed in the context of cisplatin-resistant CCC. Treatment with perifosine concurrently with cisplatin significantly enhanced the antitumor effect of cisplatin. Moreover, perifosine showed significant antitumor activity in CCC-derived tumors that had acquired resistance to bevacizumab or cisplatin. Collectively, these data reveal that AKT is frequently activated in ovarian CCCs and is a promising therapeutic target in aggressive forms of ovarian cancer., Implications: AKT-targeted therapy has value in a first-line setting as well as a second-line treatment for recurrent disease developing after platinum-based chemotherapy or bevacizumab treatment., (©2014 American Association for Cancer Research.)

Published
2015
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