1. T cell acute lymphoblastic leukaemia presenting with sudden onset right oculomotor nerve palsy with normal neuroradiography and cerebrospinal fluid studies
- Author
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Sulagna Misra, Kavitha Paramanathan, Rajiv Bartaula, Vijaya Raj Bhatt, Qun Dai, Muhammad Popalzai, Srujitha Murukutla, and Muniba Naqi
- Subjects
Adult ,medicine.medical_specialty ,Pathology ,Neurology ,Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ,Article ,Diagnosis, Differential ,Cerebrospinal fluid ,Antineoplastic Combined Chemotherapy Protocols ,Oculomotor Nerve Diseases ,medicine ,Humans ,Palsy ,medicine.diagnostic_test ,business.industry ,Cranial nerves ,Magnetic resonance imaging ,General Medicine ,Combined Modality Therapy ,Magnetic Resonance Imaging ,Neuroradiography ,Female ,Right oculomotor nerve ,Differential diagnosis ,business ,Sudden onset - Abstract
Leptomeningeal disease presenting with neurological dysfunction is not uncommon in leukaemia. However, it is often accompanied by abnormalities in cerebrospinal fluid (CSF) studies and/or neuroradiography. Here, the authors describe a case of a young patient presenting with sudden onset right oculomotor nerve palsy with normal neuroradiography and CSF studies, who was subsequently diagnosed to have T cell acute lymphoblastic leukaemia (T-ALL). This case highlights that neurological manifestations can be the initial presenting feature of T-ALL and can occur suddenly despite normal neuroradiography and initial CSF studies.
- Published
- 2012
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