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3. Endotoxin Engages Mitochondrial Quality Controlviaan iNOS-Reactive Oxygen Species Signaling Pathway in Hepatocytes

Author

Cyr, Anthony, primary, Chambers, Lauran, additional, Waltz, Paul K., additional, Whelan, Sean P., additional, Kohut, Lauryn, additional, Carchman, Evie, additional, Dyer, Mitchell, additional, Luciano, Jason, additional, Kautza, Benjamin, additional, Gomez, Hernando D., additional, Otterbein, Leo E., additional, Rosengart, Matthew R., additional, Shiva, Sruti, additional, and Zuckerbraun, Brian S., additional

Published
2019
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6. Inhaled Carbon Monoxide Protects against the Development of Shock and Mitochondrial Injury following Hemorrhage and Resuscitation

Author

Gomez, Hernando, primary, Kautza, Benjamin, additional, Escobar, Daniel, additional, Nassour, Ibrahim, additional, Luciano, Jason, additional, Botero, Ana Maria, additional, Gordon, Lisa, additional, Martinez, Silvia, additional, Holder, Andre, additional, Ogundele, Olufunmilayo, additional, Loughran, Patricia, additional, Rosengart, Matthew R., additional, Pinsky, Michael, additional, Shiva, Sruti, additional, and Zuckerbraun, Brian S., additional

Published
2015
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8. Carbon Monoxide Protects Against Hemorrhagic Shock and Resuscitation–Induced Microcirculatory Injury and Tissue Injury

Author

Nassour, Ibrahim, primary, Kautza, Benjamin, additional, Rubin, Mark, additional, Escobar, Daniel, additional, Luciano, Jason, additional, Loughran, Patricia, additional, Gomez, Hernando, additional, Scott, Jeffrey, additional, Gallo, David, additional, Brumfield, John, additional, Otterbein, Leo E., additional, and Zuckerbraun, Brian S., additional

Published
2015
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9. Blue light reduces organ injury from ischemia and reperfusion.

Author

Du Yuan, Collage, Richard D., Hai Huang, Xianghong Zhang, Kautza, Benjamin C., Lewis, Anthony J., Zuckerbraun, Brian S., Tsung, Allan, Angus, Derek C., and Rosengart, Matthew R.

Subjects
PHYSIOLOGICAL effects of blue light, LIVER injuries, NECROSIS, MYELOPEROXIDASE
Abstract

Evidence suggests that light and circadian rhythms profoundly influence the physiologic capacity with which an organism responds to stress. However, the ramifications of light spectrum on the course of critical illness remain to be determined. Here, we show that acute exposure to bright blue spectrum light reduces organ injury by comparison with bright red spectrum or ambient white fluorescent light in two murine models of sterile insult: warm liver ischemia/reperfusion (I/R) and unilateral renal I/R. Exposure to bright blue light before I/R reduced hepatocellular injury and necrosis and reduced acute kidney injury and necrosis. In both models, blue light reduced neutrophil influx, as evidenced by reduced myeloperoxidase (MPO) within each organ, and reduced the release of high-mobility group box 1 (HMGB1), a neutrophil chemotactant and key mediator in the pathogenesis of I/R injury. The protective mechanism appeared to involve an optic pathway and was mediated, in part, by a sympathetic (β3 adrenergic) pathway that functioned independent of significant alterations in melatonin or corticosterone concentrations to regulate neutrophil recruitment. These data suggest that modifying the spectrum of light may offer therapeutic utility in sterile forms of cellular injury. [ABSTRACT FROM AUTHOR]

Published
2016
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