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2. Immune mapping of human tuberculosis and sarcoidosis lung granulomas

Author

Carow, Berit, primary, Muliadi, Victoria, additional, Skålén, Kristina, additional, Yokota, Chika, additional, Kathamuthu, Gokul Raj, additional, Setiabudiawan, Todia Pediatama, additional, Lange, Christoph, additional, Scheu, Katrin, additional, Gaede, Karoline I., additional, Goldmann, Torsten, additional, Pandita, Ankur, additional, Masood, Kiran Iqbal, additional, Pervez, Shahid, additional, Grunewald, Johan, additional, Hasan, Zahra, additional, Levin, Max, additional, and Rottenberg, Martin E., additional

Published
2024
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6. Differential Frequencies of Intermediate Monocyte Subsets Among Individuals Infected With Drug-Sensitive or Drug-Resistant Mycobacterium tuberculosis

Author

Sampath, Pavithra, primary, Natarajan, Alangudi Palaniappan, additional, Moideen, Kadar, additional, Kathamuthu, Gokul Raj, additional, Hissar, Syed, additional, Dhanapal, Madhavan, additional, Jayabal, Lavanya, additional, Ramesh, Paranchi Murugesan, additional, Tripathy, Srikanth Prasad, additional, Ranganathan, Uma Devi, additional, Babu, Subash, additional, and Bethunaickan, Ramalingam, additional

Published
2022
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15. Dominant expansion of CD4+, CD8+ T and NK cells expressing Th1/Tc1/Type 1 cytokines in culture-positive lymph node tuberculosis.

Author

Kathamuthu, Gokul Raj, Sridhar, Rathinam, Baskaran, Dhanaraj, and Babu, Subash

Subjects
*KILLER cells, *CYTOTOXIC T cells, *LYMPH nodes, *TUBERCULOSIS, *CYTOKINES, *T cells, *TH1 cells
Abstract

Lymph node culture-positive tuberculosis (LNTB+) is associated with increased mycobacterial antigen-induced pro-inflammatory cytokine production compared to LN culture-negative tuberculosis (LNTB-). However, the frequencies of CD4+, CD8+ T cells and NK cells expressing Th1/Tc1/Type 1 (IFNγ, TNFα, IL-2), Th17/Tc17/Type 17 (IL-17A, IL-17F, IL-22) cytokines and cytotoxic (perforin [PFN], granzyme [GZE] B, CD107a) markers in LNTB+ and LNTB- individuals are not known. Thus, we have studied the unstimulated (UNS) and mycobacterial antigen-induced frequencies of CD4+, CD8+ T and NK cells expressing Th1, Th17 cytokines and cytotoxic markers using flow cytometry. The frequencies of CD4+, CD8+ T and NK cells expressing cytokines and cytotoxic markers were not significantly different between LNTB+ and LNTB- individuals in UNS condition. In contrast, upon Mtb antigen stimulation, LNTB+ individuals are associated with significantly increased frequencies of CD4+ T cells (PPD [IFNγ, TNFα], ESAT-6 PP [IFNγ, TNFα], CFP-10 PP [IFNγ, TNFα, IL-2]), CD8+ T cells (PPD [IFNγ], ESAT-6 PP [IFNγ], CFP-10 PP [TNFα]) and NK cells (PPD [IFNγ, TNFα], ESAT-6 PP [IFNγ, TNFα], CFP-10 PP [TNFα]) expressing Th1/Tc1/Type 1, but not Th17/Tc17/Type 17 cytokines and cytotoxic markers compared to LNTB- individuals. LNTB+ individuals did not show any significant alterations in the frequencies of CD4+, CD8+ T cells and NK cells expressing cytokines and cytotoxic markers compared to LNTB- individuals upon HIV Gag PP and P/I antigen stimulation. Increased frequencies of CD4+, CD8+ T and NK cells expressing Th1/Tc1/Type 1 cytokines among the LNTB+ group indicates that the presence of mycobacteria plays a dominant role in the activation of key correlates of immune protection or induces higher immunopathology. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Tuberculous Lymphadenitis Is Associated with Enhanced Baseline and Antigen-Specific Induction of Type 1 and Type 17 Cytokines and Reduced Interleukin-1β (IL-1β) and IL-18 at the Site of Infection

Author

Kathamuthu, Gokul Raj, primary, Moideen, Kadar, additional, Baskaran, Dhanaraj, additional, Banurekha, Vaithilingam V., additional, Nair, Dina, additional, Sekar, Gomathi, additional, Sridhar, Rathinam, additional, Vidyajayanthi, Bharathi, additional, Gajendraraj, Ganeshan, additional, Parandhaman, Dinesh Kumar, additional, Srinivasan, Alena, additional, and Babu, Subash, additional

Published
2017
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26. Fungal taxol extracted from Cladosporium oxysporum induces apoptosis in T47D human breast cancer cell line

Author

Kathamuthu Gokul Raj, Mohan Pandi, Shanmugam Sambantham, Chinnansamy Arulvasu, and Ramar Manikanadan

Subjects
Cancer Research, Paclitaxel, Epidemiology, DNA damage, bcl-X Protein, Down-Regulation, Antineoplastic Agents, Apoptosis, Breast Neoplasms, DNA Fragmentation, Biology, Flow cytometry, Fungal Proteins, chemistry.chemical_compound, Cell Line, Tumor, medicine, Humans, MTT assay, Cell Proliferation, bcl-2-Associated X Protein, medicine.diagnostic_test, Caspase 3, Public Health, Environmental and Occupational Health, NF-kappa B, Cytochromes c, Cell Cycle Checkpoints, Cell cycle, Molecular biology, Antineoplastic Agents, Phytogenic, Mitochondria, Up-Regulation, Oncology, chemistry, Cancer cell, DNA fragmentation, Female, Growth inhibition, Cladosporium
Abstract

Purpose: The present study concerns molecular mechanisms involved in induction of apoptosis by a fungal taxol extracted from the fungus Cladosporium oxysporum in T47D human breast cancer cells. Materials and Methods: Apoptosis-induced by the fungal taxol was assessed by MTT assay, nuclear staining, DNA fragmentation, flow cytometry and pro- as well as anti-apoptotic protein expression by Western blotting. Results: Our results showed inhibition of T47D cell proliferation with an IC 50 value of 2.5 μM/ml after 24 h incubation. It was suggested that the extract may exert its anti-proliferative effect on human breast cancer cell line by suppressing growth, arresting through the cell cycle, increase in DNA fragmentation as well as down-regulation of the expression of NF-ĸB, Bcl-2 and Bcl-XL and up-regulation of pro-apoptotic proteins like Bax, cyt-C and caspase-3. Conclusions: We propose that the fungal taxol contributes to growth inhibition in the human breast cancer cell through apoptosis induction via a mitochondrial mediated pathway, with possible potential as an anticancer therapeutic agent.

Published
2014

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