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25 results on '"Kasai, Michi"'

4. Pregnancy outcomes in patients with familial Mediterranean fever: systematic review and meta-analysis

Author

Hirahara, Yuhya, primary, Yamaguchi, Midori, additional, Takase-Minegishi, Kaoru, additional, Kirino, Yohei, additional, Aoki, Shigeru, additional, Hirahara, Lisa, additional, Obata, Soichiro, additional, Kasai, Michi, additional, Maeda, Ayaka, additional, Tsuchida, Naomi, additional, Yoshimi, Ryusuke, additional, Horita, Nobuyuki, additional, Nakajima, Hideaki, additional, and Miyagi, Etsuko, additional

Published
2023
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5. A case of cardiac arrest due to postpartum hemorrhage treated with hysterectomy and extracorporeal membrane oxygenation.

Author

Tsuchiya, Naoki, Obata, Soichiro, Kasai, Michi, Miyagi, Etsuko, and Aoki, Shigeru

Subjects
EXTRACORPOREAL membrane oxygenation, POSTPARTUM hemorrhage, DISSEMINATED intravascular coagulation, CARDIAC arrest, HYSTERECTOMY
Abstract

Key Clinical Message: Although extracorporeal membrane oxygenation is relatively contraindicated in patients with severe disseminated intravascular coagulation (DIC), it can be safely introduced by providing adequate anti‐DIC therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb)

Author

Maki, Shintaro, primary, Tanaka, Hiroaki, additional, Takakura, Sho, additional, Nii, Masafumi, additional, Tanaka, Kayo, additional, Ogura, Toru, additional, Kotera, Mayumi, additional, Nishimura, Yuki, additional, Tamaru, Satoshi, additional, Ushida, Takafumi, additional, Tanaka, Yasuhiro, additional, Kikuchi, Norihiko, additional, Kinjo, Tadatsugu, additional, Kawamura, Hiroshi, additional, Takano, Mayumi, additional, Nakamura, Koji, additional, Suga, Sachie, additional, Kasai, Michi, additional, Yasui, Osamu, additional, Nagao, Kenji, additional, Maegawa, Yuka, additional, Kotani, Tomomi, additional, Endo, Masayuki, additional, Yasuhi, Ichiro, additional, Aoki, Shigeru, additional, Aoki, Yoichi, additional, Yoshida, Yoshio, additional, Nakata, Masahiko, additional, Sekizawa, Akihiko, additional, and Ikeda, Tomoaki, additional

Published
2022
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8. Parasympathetic activity is the key regulator of heart rate variability between decelerations during brief repeated umbilical cord occlusions in fetal sheep

Author

Lear, Christopher A., primary, Westgate, Jenny A., additional, Kasai, Michi, additional, Beacom, Michael J., additional, Maeda, Yoshiki, additional, Magawa, Shoichi, additional, Miyagi, Etsuko, additional, Ikeda, Tomoaki, additional, Bennet, Laura, additional, and Gunn, Alistair J., additional

Published
2020
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10. Peripheral chemoreflex control of fetal heart rate decelerations overwhelms the baroreflex during brief umbilical cord occlusions in fetal sheep

Author

Lear, Christopher A., primary, Kasai, Michi, additional, Booth, Lindsea C., additional, Drury, Paul P., additional, Davidson, Joanne O., additional, Maeda, Yoshiki, additional, Magawa, Shoichi, additional, Miyagi, Etsuko, additional, Ikeda, Tomoaki, additional, Westgate, Jenny A., additional, Bennet, Laura, additional, and Gunn, Alistair J., additional

Published
2020
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11. Circulating catecholamines partially regulate T-wave morphology but not heart rate variability during repeated umbilical cord occlusions in fetal sheep

Author

Lear, Christopher A., primary, Beacom, Michael J., additional, Kasai, Michi, additional, Westgate, Jenny A., additional, Galinsky, Robert, additional, Magawa, Shoichi, additional, Miyagi, Etsuko, additional, Ikeda, Tomoaki, additional, Bennet, Laura, additional, and Gunn, Alistair J., additional

Published
2020
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13. Antithrombin deficiency in pregnancy

Author

Morikawa, Mamoru, Suzuki, Hirotada, Obata-Yasuoka, Mana, Kasai, Michi, Itoh, Hiroaki, Ohkuchi, Akihide, Hamada, Hiromi, Aoki, Shigeru, Kanayama, Naohiro, and Minakami, Hisanori

Subjects
acute fatty liver of pregnancy, antithrombin activity, maternal mortality, pregnancy complication, HELLP syndrome, disseminated intravascular coagulation
Abstract

Background and Aim: Liver dysfunction with decreased antithrombin activity (AT) and/or thrombocytopenia is life-threatening in pregnant women. Whether AT is clinically useful for prediction of liver dysfunction remains unclear. Methods: A total of 541 women were registered prospectively at gestational week 34.7 (20.0 - 41.4) with available data on antenatal AT and platelet count (PLC). Results: Liver dysfunction defined as serum AST > 45 IU/L concomitant with lactate dehydrogenase (LDH) > 400 IU/L occurred in five women antenatally (≤ 2 weeks before delivery) and in 17 women postpartum (within 1 week postpartum). Median (5th - 95th) antenatal value was 85 (62 - 110)% for AT and 202 (118 - 315)×10^9/L for PLC in the 541 women, and was significantly lower in women with than without perinatal liver dysfunction; 75 (51 - 108) vs. 86 (62 - 110)% and 179 (56 - 244) vs. 203 (121 - 316)×10^9/L, respectively. Nineteen (86%) women with liver dysfunction showed AT ≤ 62% or thrombocytopenia (PLC ≤ 118×10^9/L) perinatally, but five lacked thrombocytopenia throughout the perinatal period. The best cut-off (AT, 77%; PLC, 139×10^9/L) suggested by receiver operating characteristic curve gave antenatal AT and PLC sensitivity of 59% and 41% with positive predictive value (PPV) of 8.6% and 14%, respectively, and combined use of AT and PLC improved sensitivity to 73% (16/22) with PPV of 9.2% for prediction of perinatal liver dysfunction. Conclusions: Reduced AT not accompanied by thrombocytopenia can precede liver dysfunction. Clinical introduction of AT may enhance safety of pregnant women.

Published
2017

15. Expectant Management Leading to Successful Vaginal Delivery following Intrauterine Fetal Death in a Woman with an Incarcerated Uterus

Author

Yamamoto, Masafumi, Takami, Mio, Shindo, Ryosuke, Kasai, Michi, and Aoki, Shigeru

Subjects
Article Subject
Abstract

Expectant management leads to successful vaginal delivery following intrauterine fetal death in a woman with an incarcerated uterus. Management of intrauterine fetal death in the second or third trimester of pregnancy in women with an incarcerated uterus is challenging. We report a case of successful vaginal delivery following intrauterine fetal death by expectant management in a woman with an incarcerated uterus. In cases of intrauterine fetal death in women with an incarcerated uterus, vaginal delivery may be possible if the incarceration is successfully reduced. If the reduction is impossible, expectant management can reduce uterine retroversion, thereby leading to spontaneous reduction of the incarcerated uterus. Thereafter, vaginal delivery may be possible.

Published
2017
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17. Association of antenatal antithrombin activity with perinatal liver dysfunction : A prospective multicenter study

Author

1000000374380, Morikawa, Mamoru, Suzuki, Hirotada, 1000020420086, Obata-Yasuoka, Mana, Kasai, Michi, Itoh, Hiroaki, 1000010306136, Ohkuchi, Akihide, 1000060261799, Hamada, Hiromi, Aoki, Shigeru, Kanayama, Naohiro, 1000040102256, Minakami, Hisanori, 1000000374380, Morikawa, Mamoru, Suzuki, Hirotada, 1000020420086, Obata-Yasuoka, Mana, Kasai, Michi, Itoh, Hiroaki, 1000010306136, Ohkuchi, Akihide, 1000060261799, Hamada, Hiromi, Aoki, Shigeru, Kanayama, Naohiro, 1000040102256, and Minakami, Hisanori

Abstract

Background and Aim: Liver dysfunction with decreased antithrombin activity (AT) and/or thrombocytopenia is life-threatening in pregnant women. Whether AT is clinically useful for prediction of liver dysfunction remains unclear. Methods: A total of 541 women were registered prospectively at gestational week 34.7 (20.0 - 41.4) with available data on antenatal AT and platelet count (PLC). Results: Liver dysfunction defined as serum AST > 45 IU/L concomitant with lactate dehydrogenase (LDH) > 400 IU/L occurred in five women antenatally (≤ 2 weeks before delivery) and in 17 women postpartum (within 1 week postpartum). Median (5th - 95th) antenatal value was 85 (62 - 110)% for AT and 202 (118 - 315)×10^9/L for PLC in the 541 women, and was significantly lower in women with than without perinatal liver dysfunction; 75 (51 - 108) vs. 86 (62 - 110)% and 179 (56 - 244) vs. 203 (121 - 316)×10^9/L, respectively. Nineteen (86%) women with liver dysfunction showed AT ≤ 62% or thrombocytopenia (PLC ≤ 118×10^9/L) perinatally, but five lacked thrombocytopenia throughout the perinatal period. The best cut-off (AT, 77%; PLC, 139×10^9/L) suggested by receiver operating characteristic curve gave antenatal AT and PLC sensitivity of 59% and 41% with positive predictive value (PPV) of 8.6% and 14%, respectively, and combined use of AT and PLC improved sensitivity to 73% (16/22) with PPV of 9.2% for prediction of perinatal liver dysfunction. Conclusions: Reduced AT not accompanied by thrombocytopenia can precede liver dysfunction. Clinical introduction of AT may enhance safety of pregnant women.

Published
2017

18. Association of antenatal antithrombin activity with perinatal liver dysfunction : A prospective multicenter study

Author

Morikawa, Mamoru, Suzuki, Hirotada, Obata-Yasuoka, Mana, Kasai, Michi, Itoh, Hiroaki, Ohkuchi, Akihide, Hamada, Hiromi, Aoki, Shigeru, Kanayama, Naohiro, Minakami, Hisanori, Morikawa, Mamoru, Suzuki, Hirotada, Obata-Yasuoka, Mana, Kasai, Michi, Itoh, Hiroaki, Ohkuchi, Akihide, Hamada, Hiromi, Aoki, Shigeru, Kanayama, Naohiro, and Minakami, Hisanori

Abstract

Background and Aim: Liver dysfunction with decreased antithrombin activity (AT) and/or thrombocytopenia is life-threatening in pregnant women. Whether AT is clinically useful for prediction of liver dysfunction remains unclear. Methods: A total of 541 women were registered prospectively at gestational week 34.7 (20.0 - 41.4) with available data on antenatal AT and platelet count (PLC). Results: Liver dysfunction defined as serum AST > 45 IU/L concomitant with lactate dehydrogenase (LDH) > 400 IU/L occurred in five women antenatally (≤ 2 weeks before delivery) and in 17 women postpartum (within 1 week postpartum). Median (5th - 95th) antenatal value was 85 (62 - 110)% for AT and 202 (118 - 315)×10^9/L for PLC in the 541 women, and was significantly lower in women with than without perinatal liver dysfunction; 75 (51 - 108) vs. 86 (62 - 110)% and 179 (56 - 244) vs. 203 (121 - 316)×10^9/L, respectively. Nineteen (86%) women with liver dysfunction showed AT ≤ 62% or thrombocytopenia (PLC ≤ 118×10^9/L) perinatally, but five lacked thrombocytopenia throughout the perinatal period. The best cut-off (AT, 77%; PLC, 139×10^9/L) suggested by receiver operating characteristic curve gave antenatal AT and PLC sensitivity of 59% and 41% with positive predictive value (PPV) of 8.6% and 14%, respectively, and combined use of AT and PLC improved sensitivity to 73% (16/22) with PPV of 9.2% for prediction of perinatal liver dysfunction. Conclusions: Reduced AT not accompanied by thrombocytopenia can precede liver dysfunction. Clinical introduction of AT may enhance safety of pregnant women.

Published
2017

23. Parasympathetic activity is the key regulator of heart rate variability between decelerations during brief repeated umbilical cord occlusions in fetal sheep.

Author

Lear CA, Westgate JA, Kasai M, Beacom MJ, Maeda Y, Magawa S, Miyagi E, Ikeda T, Bennet L, and Gunn AJ

Subjects
Animals, Deceleration, Female, Fetal Hypoxia physiopathology, Pregnancy, Heart Rate, Fetal, Parasympathetic Nervous System physiology, Sheep, Umbilical Cord blood supply
Abstract

Fetal heart rate variability (FHRV) is a widely used index of intrapartum well being. Both arms of the autonomic system regulate FHRV under normoxic conditions in the antenatal period. However, autonomic control of FHRV during labor when the fetus is exposed to repeated, brief hypoxemia during uterine contractions is poorly understood. We have previously shown that the sympathetic nervous system (SNS) does not regulate FHRV during labor-like hypoxia. We therefore investigated the hypothesis that the parasympathetic system is the main mediator of intrapartum FHRV. Twenty-six chronically instrumented fetal sheep at 0.85 of gestation received either bilateral cervical vagotomy ( n = 7), atropine sulfate ( n = 7), or sham treatment (control, n = 12), followed by three 1-min complete umbilical cord occlusions (UCOs) separated by 4-min reperfusion periods. Parasympathetic blockade reduced three measures of FHRV before UCOs (all P < 0.01). Between UCOs, atropine and vagotomy were associated with marked tachycardia (both P < 0.005), suppressed measures of FHRV (all P < 0.01), and abolished FHRV on visual inspection compared with the control group. Tachycardia in the atropine and vagotomy groups resolved over the first 10 min after the final UCO, in association with evidence that the SNS contribution to FHRV progressively returned during this time. Our findings support that SNS control of FHRV is acutely suppressed for at least 4 min after a deep intrapartum deceleration and takes 5-10 min to recover. The parasympathetic system is therefore likely to be the key mediator of FHRV once frequent FHR decelerations are established during labor.

Published
2020
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25. Circulating catecholamines partially regulate T-wave morphology but not heart rate variability during repeated umbilical cord occlusions in fetal sheep.

Author

Lear CA, Beacom MJ, Kasai M, Westgate JA, Galinsky R, Magawa S, Miyagi E, Ikeda T, Bennet L, and Gunn AJ

Subjects
Adrenergic beta-Agonists pharmacology, Adrenergic beta-Antagonists pharmacology, Adult, Animals, Catecholamines blood, Electrocardiography, Female, Fetal Hypoxia physiopathology, Humans, Hypoxia physiopathology, Labor, Obstetric, Pregnancy, Propranolol pharmacology, Catecholamines physiology, Heart Rate, Fetal physiology, Sheep, Domestic physiology, Umbilical Cord physiology
Abstract

Fetal heart rate (FHR) variability (FHRV) and ST segment morphology are potential clinical indices of fetal well-being during labor. β-Adrenergic stimulation by circulating catecholamines has been hypothesized to contribute to both FHRV and ST segment morphology during labor, but this has not been tested during brief repeated fetal hypoxemia that is characteristic of labor. Near-term fetal sheep (0.85 gestation) received propranolol (β-adrenergic blockade; n = 10) or saline ( n = 7) 30 min before being exposed to three 2-min complete umbilical cord occlusions (UCOs) separated by 3-min reperfusions. T/QRS ratio was calculated throughout UCOs and reperfusion periods, and measures of FHRV (RMSSD, SDNN, and STV) were calculated between UCOs. During the baseline period, before the start of UCOs, propranolol was associated with reduced FHR, SDNN, and STV but did not affect RMSSD or T/QRS ratio. UCOs were associated with rapid FHR decelerations and increased T/QRS ratio; propranolol significantly reduced FHR during UCOs and was associated with a slower rise in T/QRS ratio during the first UCOs, without affecting the maximal rise or T/QRS ratio during the second and third UCO. Between UCOs propranolol reduced FHR and T/QRS ratio but did not affect any measure of FHRV. These data demonstrate that circulating catecholamines do not contribute to FHRV during labor-like hypoxemia. Furthermore, circulating catecholamines did not contribute to the major rise in T/QRS ratio during labor-like hypoxemia but may regulate T/QRS ratio between brief hypoxemia.

Published
2020
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