1. C to U <scp>RNA</scp> editing mediated by <scp>APOBEC</scp> 1 requires <scp>RNA</scp> ‐binding protein <scp>RBM</scp> 47
- Author
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David A.F. Loebel, Kristen Barratt, Vanessa Jones, Doreen Liebhold, Nicolas Fossat, Tania Radziewic, Melinda Power, Patrick P.L. Tam, Karin Tourle, and Joshua B. Studdert
- Subjects
Apolipoprotein B ,APOBEC-1 Deaminase ,Gene Expression ,Mice, Transgenic ,RNA-binding protein ,Cytidine ,Biochemistry ,chemistry.chemical_compound ,Cytidine Deaminase ,Gene expression ,Genetics ,Animals ,Humans ,RNA, Messenger ,Uridine ,Molecular Biology ,Cell Nucleus ,biology ,APOBEC1 ,Scientific Reports ,RNA-Binding Proteins ,Cytidine deaminase ,Molecular biology ,Cell biology ,Protein Transport ,chemistry ,RNA editing ,biology.protein ,RNA Editing ,Caco-2 Cells - Abstract
Cytidine (C) to Uridine (U) RNA editing is a post-transcriptional modification that is accomplished by the deaminase APOBEC1 and its partnership with the RNA-binding protein A1CF. We identify and characterise here a novel RNA-binding protein, RBM47, that interacts with APOBEC1 and A1CF and is expressed in tissues where C to U RNA editing occurs. RBM47 can substitute for A1CF and is necessary and sufficient for APOBEC1-mediated editing in vitro. Editing is further impaired in Rbm47-deficient mutant mice. These findings suggest that RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing.
- Published
- 2014