9 results on '"Kareva EN"'
Search Results
2. [Review of current and future directions of antiviral therapy of influenza and acute respiratory viral infections in Russia]
- Author
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Kareva En, V.A. Bulgakova, E. V. Volchkova, V. N Gorodin, E P Selkova, and N Y Pshenichnaya
- Subjects
0301 basic medicine ,Drug ,enisamium iodide ,History ,Oseltamivir ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,lcsh:Medicine ,Antiviral Agents ,Russia ,nobazid ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Immune system ,Zanamivir ,antivirals ,Drug Resistance, Viral ,Influenza, Human ,medicine ,Humans ,030212 general & internal medicine ,Respiratory system ,media_common ,biology ,business.industry ,immunomodulators ,lcsh:R ,acute respiratory viral infections ,nonsteroid anti inflammatory drugs ,General Medicine ,Clinical trial ,Enisamium Iodide ,030104 developmental biology ,chemistry ,Immunology ,biology.protein ,Family Practice ,business ,influenza ,Neuraminidase ,medicine.drug - Abstract
to determine the perspectives for the use of drugs with combined antiviral, anti - inflammatory and immunomodulatory activity on the basis of medical studies of existing antiviral drugs for the treatment of influenza and acute respiratory viral infections in Russia.A brief review of the antiviral drugs used in Russia for the treatment of influenza and acute respiratory viral infections was conducted on the basis of 37 articles published in Scopus, Web of Science (WoS), and RSCI databases in the period from 1997 to 2018.Resistance to neuraminidase inhibitors (oseltamivir, zanamivir), is slowly developing due to the mutations of the neuraminidase gene H275Y and Q136K. Most influenza A viruses remain resistant to adamantane antivirals. Repeated use of immunomodulators with indirect antiviral action leads to a hyporeactivity of the immune system and, subsequently, to a decrease in their effectiveness. Positive clinical and laboratory data in clinical trials were obtained using Enisamium iodide, a drug with combined action - direct antiviral, and immunomodulatory.According to the WHO strategy, the results of the review demonstrate the need for continued research of medications with combined antiviral and pathogenetic effects on the infectious process caused by influenza and acute respiratory viral infections.Одной из целей глобальной стратегии Всемирной организации здравоохранения (ВОЗ) по борьбе с гриппом является содействие разработке более эффективных противовирусных препаратов и иммуномодуляторов. Цель: на основе научных исследований, существующих на сегодняшний день противовирусных препаратов для терапии гриппа и острых респираторных вирусных инфекций (ОРВИ) в Российской Федерации определить перспективы использования лекарственных средств с комбинированной противовирусной, противовоспалительной и иммуномодулирующей активностью. Материалы и методы. На основе 37 научных публикаций за период с 1997 по 2018 г., размещенных в реферативных базах данных Scopus, Web of Science (WoS), РИНЦ, проведен краткий обзор широко используемых в российской практической медицине противовирусных препаратов для лечения гриппа и ОРВИ. Результаты. В арсенале практикующего врача для борьбы с ОРВИ и гриппом имеются противовирусные средства с различными механизмами действия. К ингибиторам нейраминидазы (осельтамивиру, занамивиру) медленно развивается резистентность, связанная с мутациями в гене нейраминидазы H275Y и Q136K. Продолжает сохраняться резистентность большинства вирусов гриппа типа А к производным адамантана (амантадину и римантадину). Гипореактивность иммунной системы при повторном назначении иммуномодуляторов с непрямым противовирусным действием приводит к снижению их эффективности. Позитивные данные получены при использовании в рамках клинических и доклинических исследований энисамия йодида, обладающего комбинированным действием - прямым противовирусным (влияет на процесс проникновения вирусов через клеточную мембрану), иммуномодулирующим и сопутствующим симптоматическим. Заключение. Результаты обзора согласуются со стратегией ВОЗ, демонстрируют необходимость продолжения исследования противовирусных препаратов с комбинированным действием - этиотропным, патогенетическим и симтоматическим при гриппе и ОРВИ. Энисамия йодид является одним из перспективных препаратов этиотропной и патогенетической терапии этой группы инфекционных заболеваний.
- Published
- 2020
3. Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders.
- Author
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Novakovic S, Jakovljevic V, Jovic N, Andric K, Milinkovic M, Anicic T, Pindovic B, Kareva EN, Fisenko VP, Dimitrijevic A, and Joksimovic Jovic J
- Abstract
Oxidative stress represents the pathophysiological basis for most disorders, including reproductive issues. Polycystic ovary syndrome (PCOS) is heterogeneous endocrine disorder of women characterized primarily by irregular menstrual cycles, hyper-androgenism, and ovulatory dysfunction. In the last decades, PCOS was recognized as a systemic silent inflammation and an oxidative disturbance-related disorder, exerting multifaceted symptoms, including metabolic. PCOS treatment should involve a personalized approach tailored to individual symptoms; however, the results are often unsatisfactory. Various supplementary treatments have been proposed to assist in the management and alleviation of PCOS symptoms. Cinnamon and ginger, known for millennia as herbs used in spices or traditional medicine for the treatment of various diseases, are of interest in this study. The aim of this study is to evaluate and investigate the effects of cinnamon and ginger in PCOS patients. Using relevant keywords we searched through PubMed/MEDLINE, Science Direct, Google Scholar and Web of science to find animal studies, pre-clinical, and clinical studies which were then reviewed for usage. Out of all of the reviewed studies a total of 65 studies were included in this review article. Cinnamon and ginger can affect hormonal status, lipid profile, obesity, and insulin resistance by mitigating oxidative stress and inflammation. Generally, based on current clinical evidence, it was revealed that supplementation with cinnamon or ginger had a useful impact in patients with PCOS. This review summarizes the antioxidative effects of ginger and cinnamon in PCOS treatment, highlighting their potential benefits in other oxidative stress-related pathologies.
- Published
- 2024
- Full Text
- View/download PDF
4. [The mechanisms of anti-inflammatory action of enisamium iodide].
- Author
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Kareva EN, Fedotcheva TA, Semeikin AV, Kochina NA, Krasnoshchok EV, and Shimanovskii NL
- Subjects
- Humans, Interleukin-10, Leukocytes, Mononuclear metabolism, Interleukin-6, Tumor Necrosis Factor-alpha, Interleukin-8 pharmacology, Cyclooxygenase 2 metabolism, Interleukin-4 pharmacology, Quality of Life, Anti-Inflammatory Agents pharmacology, Cytokines metabolism, Interleukin-1, NF-kappa B metabolism, NF-kappa B pharmacology, Respiratory Tract Infections
- Abstract
Aim: The role of cyclooxygenases (COX-1 and/or COX-2), transcription nuclear factor NF-κB, anti-inflammatory cytokines - TGF1b, IL-4, IL-10 and pro-inflammatory cytokines IL-1, IL-6 were studied to substantiate the expediency of antiviral agent enisamium iodide (Nobazit) using to regulate key inflammatory components in acute respiratory infections, IL-8, TNF-alpha in the realization of the pharmacological activity of this drug., Materials and Methods: Gene expression was determined by real-time RT-PCR, the concentration of interleukins was determined by ELISA, and the viability of peripheral blood mononuclear cells (PBMC) was assessed by the MTT spectrophotometric method. The chemiluminescence method was used to assess PBMC oxidant activity., Results: Enisamium iodide (10 μM) reduced mRNA levels of COX-1, COX-2, NF-κB, TGF1b, IL-1, IL-6 in stimulated PBMC of healthy donors by an average of 48% ( p ≤0.05). At 5 times higher concentration, 50 μM, enisamium iodide suppressed the expression of these genes by an average of 43% ( p ≤0.05). At a concentration of 100 μM, enisamium iodide reduced the expression of COX-2, TGF1b, IL-1, IL-6 by an average of 47% ( p ≤0.05). At a concentration of 10 μM, enisamium iodide stimulated the secretion of IL-10 by mononuclear cells by 1.2 times, p ≤0.05. The tested drug at a concentration of 50 μM did not affected on the concentration of IL-1, IL-4, IL-8 and TNF-alpha, but significantly stimulated the production of IL-10 by 1.5 times, p ≤0.05. The chemiluminescence method revealed that enisamium iodide in the entire concentration range (10-100 μM) does not reduce the viability of macrophages, but inhibits their oxidative activity (maximum value of CL intensity) by an average of 55% ( p ≤0.05)., Conclusion: The anti-inflammatory effect of enisamium iodide at a concentration of 10 μM may be associated with inhibition of the expression of COX-1, 2, NF-κB, IL-1, IL-6, TGF1b and an increase in the expression and production of IL-10. An additional contribution to the anti-inflammatory activity of enisamium iodide is made by its antioxidant and antiradical activity. The absence of the effect of enisamium iodide (10-100 µM) on the viability of PBMC indicates its safety for the cells of the immune system and the expediency of using it to suppress inflammatory reactions in acute respiratory infections, restore the quality of life of patients and the possibility of using Nobazit as an effective agent for treatment of these infections of various etiologies.
- Published
- 2022
- Full Text
- View/download PDF
5. [Pharmacoepidemiological research of COVID-19 in the Russian Federation EGIDA-2020].
- Author
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Pshenichnaya NY, Kareva EN, Leneva IA, Bulgakova VA, Kravchenko IE, Nikolaeva IV, Grekova AI, Ivanova AP, Puzyreva LV, Khasanova GM, Orlova SN, Tikhonova EP, Petrov VA, Malinin OV, Kolaeva NV, Volchkova EV, Kanshina NN, and Chulanov VP
- Subjects
- Male, Humans, Female, Middle Aged, Young Adult, Adult, Lopinavir therapeutic use, Ritonavir therapeutic use, Hydroxychloroquine therapeutic use, SARS-CoV-2, Retrospective Studies, Antiviral Agents therapeutic use, Interferons, Anti-Bacterial Agents therapeutic use, COVID-19 epidemiology
- Abstract
Aim: An analysis of coronavirus infection in Russia and evaluation of different AVT regimens effectiveness., Materials and Methods: The study involved a retrospective analysis of 1082 patient records with laboratory-confirmed COVID-19 in 17 regions of Russia. The number of men and women was equal, mean age 48.718.1 (median 50). Patients with moderate COVID-19 (85%) versus mild COVID-19 (15%) were characterized by higher age (median 54 vs 21 years; p0.001), higher body mass index (27.8 vs 23.4; p0.001), prevalence of chronic diseases (75.3% vs 8.5%; p0.001), including circulatory system diseases (37.8%). Moderate COVID-19 characterized higher intoxication (10.86.1 vs 4.22.7 days; p0.001) and catarrhal symptoms duration (10.25.4 vs 6.14.1 days; p0.001)., Results: During hospitalization 92% of the patients received AVT, 77% antibiotics, and 16% corticosteroids. Umifenovir therapy resulted in a significant reduction of intoxication (8.75.5 vs 11.75.5 days; p0.001) and catarrhal symptoms duration (8.85.1 vs 12.04.9 days; p0.001) compared to the group without AVT. The usage of INF reduced intoxication symptoms compared with the group without AVT (8.97.5 vs 11.75.5; p0.05). Therapy with hydroxychloroquine, imidazolylethanamide pentandioic acid, and lopinavir + ritonavir combination did not affect the course of COVID-19. Most of adverse reactions were related to antibiotics., Conclusion: Umifenovir therapy and inclusion of interferon in AVT regimens was associated improvement in the clinical manifestation of the disease among patients.
- Published
- 2021
- Full Text
- View/download PDF
6. [NSAID enteropathy].
- Author
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Kareva EN
- Subjects
- Anti-Inflammatory Agents, Non-Steroidal, Humans, Intestine, Small, Intestinal Diseases, Probiotics, Stomach Diseases
- Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used drugs in the world, and their side effects are very high. First of all, these are NSAID gastropathy, but in the long term, 5070% of NSAIDs cause damage to the small intestine (NSAID enteropathy), sometimes with serious consequences. To date, no drugs have been proposed with proven effectiveness to prevent this side effect. Apparently, this is not due to the fully clarified mechanism of pathogenesis. The most promising is the hypothesis of the participation of individual representatives of microflora in the development of enteropathy. Therefore, modulating the intestinal flora with the help of probiotics can be the basic therapeutic strategy for the prevention and treatment of such damage.
- Published
- 2020
- Full Text
- View/download PDF
7. [Review of current and future directions of antiviral therapy of influenza and acute respiratory viral infections in Russia].
- Author
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Pshenichnaya NY, Bulgakova VA, Volchkova EV, Kareva EN, Selkova EP, and Gorodin VN
- Subjects
- Drug Resistance, Viral drug effects, Humans, Oseltamivir, Russia, Zanamivir therapeutic use, Antiviral Agents therapeutic use, Influenza, Human drug therapy
- Abstract
Aim: to determine the perspectives for the use of drugs with combined antiviral, anti - inflammatory and immunomodulatory activity on the basis of medical studies of existing antiviral drugs for the treatment of influenza and acute respiratory viral infections in Russia., Materials and Methods: A brief review of the antiviral drugs used in Russia for the treatment of influenza and acute respiratory viral infections was conducted on the basis of 37 articles published in Scopus, Web of Science (WoS), and RSCI databases in the period from 1997 to 2018., Results: Resistance to neuraminidase inhibitors (oseltamivir, zanamivir), is slowly developing due to the mutations of the neuraminidase gene H275Y and Q136K. Most influenza A viruses remain resistant to adamantane antivirals. Repeated use of immunomodulators with indirect antiviral action leads to a hyporeactivity of the immune system and, subsequently, to a decrease in their effectiveness. Positive clinical and laboratory data in clinical trials were obtained using Enisamium iodide, a drug with combined action - direct antiviral, and immunomodulatory., Conclusion: According to the WHO strategy, the results of the review demonstrate the need for continued research of medications with combined antiviral and pathogenetic effects on the infectious process caused by influenza and acute respiratory viral infections.
- Published
- 2019
- Full Text
- View/download PDF
8. Nephrolithiasis against type 2 diabetes mellitus: on the effect of hypoglycemic therapy on lithogenesis.
- Author
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Yarovoy SK, Kareva EN, and Djalilov OV
- Subjects
- Humans, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents adverse effects, Hypoglycemic Agents therapeutic use, Nephrolithiasis chemically induced
- Abstract
Aim: To study the effects of oral hypoglycemic agents that can affect the probability of recurrence of nephrolithiasis., Materials and Methods: The article is based on the results of examination and treatment of 315 patients suffering from recurrent nephroli-thiasis and medically compensated type 2 diabetes mellitus treated at the N.A. Lopatkin Institute of Urology and Interventional Radio-logy - the branch of the SMRC of Radiology, Ministry of Health of Russia and D.D. Pletnev City Hospital Moscow Healthcare -Department in 2012-2017. The patients were divided into three groups according to the applied tool antidiabetic: metformin, glibenclamide, canagliflozin. The control group consisted of patients receiving insulin therapy., Results: The propensity of Metformin to reduce the pH of urine, which has a negative impact in the conditions of urate nephrolithiasis, which is most common in the population of patients with type 2 diabetes mellitus. Glibenclamide, on the contrary, somewhat latches urine. But changes in the reaction of urine under the influence of the drug do not go beyond normal values and are not clinically significant. Canagliflozin increases diuresis due to medication induced glycosuria and stimulates renal excretion of uric acid and its salts. However canagliflozin does not cause significant shifts in the pH of urine that may somewhat negates the increased risk of recurrence of urate stone formation in the background of the uricosuric effect of the drug., Conclusion: Drug therapy of type 2 diabetes mellitus significantly affects the properties of urine from patients with nephrolithiasis.
- Published
- 2018
- Full Text
- View/download PDF
9. [Concentrations of urine 6-sulfatoxymelatonin during the treatment of patients with epilepsy: a pilot clinical trial].
- Author
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Avakian GN, Oleĭnikova OM, Kareva EN, Bogomazova MA, Lagutin IuV, and Avakian GG
- Subjects
- Adult, Female, Humans, Male, Melatonin urine, Middle Aged, Pilot Projects, Anticonvulsants administration & dosage, Carbamazepine administration & dosage, Epilepsies, Partial drug therapy, Epilepsies, Partial urine, Melatonin analogs & derivatives, Valproic Acid administration & dosage
- Abstract
The effect of the epiphysis hormone melatonin on the brain bioelectrical activity is understudied: the data of experimental and clinical studies of melatonin effects are inconclusive and related mostly to exogenous administration. We studied 43 patients with focal epilepsy, 25 patients with cryptogenic epilepsy and 18 with symptomatic epilepsy. Carbamazepine and valproate were used as anticonvulsive drugs. Morning and evening urine concentrations of 6-sulfatoxymelatonin (6-COM), the main melatonin metabolite, were determined twice using immunoassay method: in autumn at the inclusion in the study and beginning of the anticonvulsant treatment and after 6 months, in spring, when anticonvulsant doses had been adjusted. The presence of epileptic seizures was associated with the reduction of melatonin concentration in the body that was supported by the decrease of urine 6-COM, in particular in the morning, in non-treated patients. Prescription of anticonvulsant treatment resulted in the increase of 6-COM. The concentration of the morning urine 6-COM was higher in patients with focal epilepsy receiving anticonvulsant treatment with valproate compared to those receiving carbamazepine: 49.28±6.71 and 37.09±5.43 ng/ml versus 20.00±3.6 and 13.11±2.08 ng/ml in patients treated with valproate and carbamazepine, respectively, before and after the adjustment.
- Published
- 2012
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