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3. Comparison of Unrelated Cord Blood Transplantation and HLA-Mismatched Unrelated Bone Marrow Transplantation for Adults with Leukemia

Author

Atsuta, Yoshiko, Morishima, Yasuo, Suzuki, Ritsuro, Nagamura-Inoue, Tokiko, Taniguchi, Shuichi, Takahashi, Satoshi, Kai, Shunro, Sakamaki, Hisashi, Kouzai, Yasushi, Kobayashi, Naoki, Fukuda, Takahiro, Azuma, Hiroshi, Takanashi, Minoko, Mori, Takehiko, Tsuchida, Masahiro, Kawase, Takakazu, Kawa, Keisei, Kodera, Yoshihisa, and Kato, Shunichi

Published
2012
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5. Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study

Author

Kanda, Junya, Hishizawa, Masakatsu, Utsunomiya, Atae, Taniguchi, Shuichi, Eto, Tetsuya, Moriuchi, Yukiyoshi, Tanosaki, Ryuji, Kawano, Fumio, Miyazaki, Yasushi, Masuda, Masato, Nagafuji, Koji, Hara, Masamichi, Takanashi, Minoko, Kai, Shunro, Atsuta, Yoshiko, Suzuki, Ritsuro, Kawase, Takakazu, Matsuo, Keitaro, Nagamura-Inoue, Tokiko, Kato, Shunichi, Sakamaki, Hisashi, Morishima, Yasuo, Okamura, Jun, Ichinohe, Tatsuo, and Uchiyama, Takashi

Published
2012
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8. Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study

Author

Hishizawa, Masakatsu, Kanda, Junya, Utsunomiya, Atae, Taniguchi, Shuichi, Eto, Tetsuya, Moriuchi, Yukiyoshi, Tanosaki, Ryuji, Kawano, Fumio, Miyazaki, Yasushi, Masuda, Masato, Nagafuji, Koji, Hara, Masamichi, Takanashi, Minoko, Kai, Shunro, Atsuta, Yoshiko, Suzuki, Ritsuro, Kawase, Takakazu, Matsuo, Keitaro, Nagamura-Inoue, Tokiko, Kato, Shunichi, Sakamaki, Hisashi, Morishima, Yasuo, Okamura, Jun, Ichinohe, Tatsuo, and Uchiyama, Takashi

Published
2010
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9. Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia

Author

Atsuta, Yoshiko, Suzuki, Ritsuro, Nagamura-Inoue, Tokiko, Taniguchi, Shuichi, Takahashi, Satoshi, Kai, Shunro, Sakamaki, Hisashi, Kouzai, Yasushi, Kasai, Masaharu, Fukuda, Takahiro, Azuma, Hiroshi, Takanashi, Minoko, Okamoto, Shinichiro, Tsuchida, Masahiro, Kawa, Keisei, Morishima, Yasuo, Kodera, Yoshihisa, and Kato, Shunichi

Published
2009
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14. HLA-DPB1 Mismatch Induces Low Hematological Relapse and Beneficial Survival in Single Unit Cord Blood Transplantation

Author

Yabe, Toshio, primary, Azuma, Fumihiro, additional, Kashiwase, Koichi, additional, Matsumoto, Kayoko, additional, Orihara, Takeshi, additional, Yabe, Hiromasa, additional, Kato, Shunichi, additional, Kato, Koji, additional, Kai, Shunro, additional, Mori, Tetsuo, additional, Morishima, Satoko, additional, Satake, Masahiro, additional, Takanashi, Minoko, additional, Nakajima, Kazunori, additional, and Morishima, Yasuo, additional

Published
2016
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15. Comparison of Outcomes after Double or Single-Unit Cord Blood Transplantation in Patients with Hematological Malignancies Using TBI-Containing Myeloablative Conditioning Regimen, a Retrospective Matched Control Study on Behalf of C-SHOT0507 and JSHCT Registry Data in Japan

Author

Wake, Atsushi, primary, Kai, Shunro, additional, Okada, Masaya, additional, Kato, Koji, additional, Uchida, Naoyuki, additional, Kobayashi, Naoki, additional, Aotsuka, Nobuyuki, additional, Ishikawa, Jun, additional, Takahashi, Satoshi, additional, Eto, Tetsuya, additional, Taniguchi, Shuichi, additional, Atsuta, Yoshiko, additional, and Kato, Shunichi, additional

Published
2014
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16. Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan

Author

Narimatsu, Hiroto, Miyakoshi, Shigesaburo, Yamaguchi, Takuhiro, Kami, Masahiro, Matsumura, Tomoko, Yuji, Koichiro, Murashige, Naoko, Kusumi, Eiji, Kodama, Yuko, Komatsu, Tsunehiko, Sakamaki, Hisashi, Kouzai, Yasushi, Okada, Masaya, Osugi, Yuko, Kobayashi, Ryoji, Inoue, Masami, Takahashi, Satoshi, Kai, Shunro, Kato, Koji, Inoue-Nagamura, Tokiko, Taniguchi, Shuichi, and Kato, Shunichi

Published
2008
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18. Contribution of HLA Incompatibility on Clinical Outcomes of CBT in Patients with MDS Including Secondary AML in Japan: Multivariate Analysis Using Competing Risk Regression Model

Author

Takahashi, Satoshi, primary, Yamaguchi, Takuhiro, primary, Monna-Ooiwa, Maki, primary, Taniguchi, Shuichi, primary, Sakamaki, Hisashi, primary, Morii, Takeshi, primary, Nagatoshi, Yoshihisa, primary, Aotsuka, Nobuyuki, primary, Kato, Shunichi, primary, Takanashi, Minoko, primary, Nagamura, Tokiko, primary, Azuma, Hiroshi, primary, Kai, Shunro, primary, Kato, Koji, primary, and Asano, Shigetaka, primary

Published
2008
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20. Allografting for Adult T-Cell Leukemia/Lymphoma: A Nationwide Retrospective Analysis.

Author

Hishizawa, Masakatsu, primary, Kanda, Junya, additional, Utsunomiya, Atae, additional, Taniguchi, Shuichi, additional, Eto, Tetsuya, additional, Moriuchi, Yukiyoshi, additional, Tanosaki, Ryuji, additional, Kawano, Fumio, additional, Miyazaki, Yasushi, additional, Nagafuji, Koji, additional, Hara, Masamichi, additional, Yoshiba, Fumiaki, additional, Takanashi, Minoko, additional, Kai, Shunro, additional, Atsuta, Yoshiko, additional, Kawase, Takakazu, additional, Nagamura-Inoue, Tokiko, additional, Matsuo, Keitaro, additional, Kato, Shunichi, additional, Morishima, Yasuo, additional, Okamura, Jun, additional, Kodera, Yoshihisa, additional, and Uchiyama, Takashi, additional

Published
2007
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21. Cord Blood Transplantation from Unrelated Donors for Children with Acute Lymphoblastic Leukemia in Japan: The Impact of Methotrexate on the Clinical Outcome.

Author

Kato, Koji, primary, Yoshimi, Ayami, primary, Ito, Etsuro, primary, Oki, Kentaro, primary, Hara, Jun, primary, Nagatoshi, Yoshihisa, primary, Kikuchi, Akira, primary, Kobayashi, Ryoji, primary, Nagamura-Inoue, Tokiko, primary, Kai, Shunro, primary, Azuma, Hiroshi, primary, Takanashi, Minoko, primary, Isoyama, Keiichi, primary, and Kato, Shunichi, primary

Published
2007
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22. Unrelated Cord Blood Transplanation for Malignant Lymphoma: A Retrospective Study from the Japan Cord Blood Bank Network (JCBNW).

Author

Takita, Morihito, primary, Yuji, Koichiro, primary, Yamaguchi, Takuhiro, primary, Matsumura, Tomoko, primary, Kami, Masahiro, primary, Sakamaki, Hisashi, primary, Kouzai, Yasushi, primary, Okada, Masaya, primary, Osugi, Yuko, primary, Kobayashi, Ryuji, primary, Inoue, Masami, primary, Takahashi, Satoshi, primary, Murata, Makoto, primary, Kai, Shunro, primary, Kato, Koji, primary, Nagamura, Tokiko, primary, Taniguchi, Shuichi, primary, and Kato, Shunichi, primary

Published
2007
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23. Acute Graft-Versus-Host Disease Following Umbilical Cord Blood Transplantation: Retrospective Survey Involving 2015 Japanese Patients.

Author

Miyakoshi, Shigesaburo, primary, Yamaguchi, Takuhiro, additional, Kami, Masahiro, additional, Matsumura, Tomoko, additional, Yuji, Koichiro, additional, Narimatsu, Hiroto, additional, Kusumi, Eiji, additional, Sakamaki, Hisashi, additional, Kouzai, Yasushi, additional, Okada, Masaya, additional, Osugi, Yuko, additional, Kobayashi, Ryuji, additional, Inoue, Masami, additional, Takahashi, Satoshi, additional, Murata, Makoto, additional, Kai, Shunro, additional, Kato, Koji, additional, Nagamura, Tokiko, additional, Taniguchi, Shuichi, additional, and Kato, Shunichi K., additional

Published
2007
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24. Comparison of 6586 Unrelated Bone Marrow Transplants (UBMT) and 2713 Unrelated Cord Blood Transplants (UCBT) in Japan.

Author

Kato, Shunichi, primary, Morishima, Yasuo, additional, Atsuta, Yoshiko, additional, Nagamura, Tokiko, additional, Takaue, Yoichiro, additional, Sakamaki, Hisashi, additional, Okamoto, Shinichiro, additional, Takahashi, Satoshi, additional, Taniguchi, Shuichi, additional, Kato, Koji, additional, Isoyama, Keiichi, additional, Takanashi, Minoko, additional, Kai, Shunro, additional, Azuma, Hiroshi, additional, Tsuchida, Masahiro, additional, Kawa, Keisei, additional, and Kodera, Yoshihisa, additional

Published
2007
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29. Infusions of Fresh Frozen Plasma to the Patients with a High-Risk Group for Hepatic VOD Associated with Stem Cell Transplantation Reduce Its Occurrence.

Author

Matsumoto, Masanori, primary, Kawa, Keisei, additional, Yagi, Hieo, additional, Park, Yong-Dong, additional, Takeshima, Yasuhiro, additional, Kosaka, Yoshiyuki, additional, Hara, Hiroshi, additional, Kai, Shunro, additional, Yamamoto, Masuji, additional, Kanemaru, Akihisa, additional, Fukuhara, Shirou, additional, Hino, Masayuki, additional, Sako, Masahiko, additional, Hiraoka, Akira, additional, Ogawa, Hiroyasu, additional, Hara, Junichi, additional, and Fujimura, Yoshihiro, additional

Published
2006
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30. Relationships between Hematological Recovery and Overall Survival in Older Adults Undergoing Allogeneic Bone Marrow Transplantation

Author

TABATA, Masahiko, primary, KAI, Shunro, additional, SATAKE, Atsushi, additional, WAKAE, Takeshi, additional, TODA, Akinari, additional, CHIN, Meishu, additional, NISHIOKA, Keisuke, additional, TANAKA, Hidehisa, additional, ITSUKUMA, Takeyoshi, additional, YAMAGUCHI, Masao, additional, OKADA, Masaya, additional, TAKATSUKA, Hiroyuki, additional, MISAWA, Mahito, additional, and HARA, Hiroshi, additional

Published
2005
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35. Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ V alpha 24+V beta 11+ natural killer T cells.

Author

Fujibayashi Y, Fujimori Y, Kasumoto I, Kai S, Hara H, Okamura H, Tsutsui H, Ogawa H, and Nakanishi K

Subjects
Cells, Cultured, Cytokines metabolism, Fetal Blood immunology, Humans, Killer Cells, Natural cytology, Killer Cells, Natural drug effects, Th1 Cells immunology, Th2 Cells immunology, CD4 Antigens metabolism, Fetal Blood cytology, Interleukin-18 pharmacology, Killer Cells, Natural immunology, Killer Cells, Natural metabolism, Lymphocyte Activation drug effects, Receptors, Antigen, T-Cell, alpha-beta metabolism, Th1 Cells drug effects, Th2 Cells drug effects
Abstract

Natural killer T (NKT) cells, exhibiting both T-cell and NK-cell markers, are known to regulate immune responses by secreting T-helper (Th) 1 and Th2 cytokines. We analyzed NKT cells in cord blood (CB) for phenotypical and functional characteristics and regulatory mechanisms that control Th1 and Th2 determination. Human CB V alpha 24+V beta 11+ NKT cells were predominantly the CD4+ single positive (SP) phenotype (approximately 96%), in contrast to adult peripheral blood V alpha 24+V beta 11+ NKT cells which are composed of a dominant population of the CD4-CD8-double negative (DN) phenotype and a minor population of the CD4+ SP phenotype. The CB CD4+ V alpha 24+ NKT cells, following stimulation with the primary culture, gained the capacity to secrete interferon (IFN)-gamma, a Th1 cytokine, and interleukin (IL)-13, a Th2 cytokine. The combination of IL-18 and IL-12 induced IFN-gamma production in CB CD4+ V alpha 24+ NKT cells, while IL-18 in combination with IL-2 induced IL-13 production in these cells. Thus, IL-18 regulates the determination of the Th1 or Th2 immune response by human CD4+ V alpha 24+ NKT cells through different cytokine combinations.

Published
2007

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