131 results on '"Körner, Philipp"'
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2. Fifty Years of Prolog and Beyond
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Körner, Philipp, Leuschel, Michael, Barbosa, João, Costa, Vítor Santos, Dahl, Verónica, Hermenegildo, Manuel V., Morales, Jose F., Wielemaker, Jan, Diaz, Daniel, Abreu, Salvador, and Ciatto, Giovanni
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Computer Science - Programming Languages - Abstract
Both logic programming in general, and Prolog in particular, have a long and fascinating history, intermingled with that of many disciplines they inherited from or catalyzed. A large body of research has been gathered over the last 50 years, supported by many Prolog implementations. Many implementations are still actively developed, while new ones keep appearing. Often, the features added by different systems were motivated by the interdisciplinary needs of programmers and implementors, yielding systems that, while sharing the "classic" core language, and, in particular, the main aspects of the ISO-Prolog standard, also depart from each other in other aspects. This obviously poses challenges for code portability. The field has also inspired many related, but quite different languages that have created their own communities. This article aims at integrating and applying the main lessons learned in the process of evolution of Prolog. It is structured into three major parts. Firstly, we overview the evolution of Prolog systems and the community approximately up to the ISO standard, considering both the main historic developments and the motivations behind several Prolog implementations, as well as other logic programming languages influenced by Prolog. Then, we discuss the Prolog implementations that are most active after the appearance of the standard: their visions, goals, commonalities, and incompatibilities. Finally, we perform a SWOT analysis in order to better identify the potential of Prolog, and propose future directions along which Prolog might continue to add useful features, interfaces, libraries, and tools, while at the same time improving compatibility between implementations., Comment: 87 pages, 2 figures. This article has been accepted for publication in Theory and Practice of Logic Programming (TPLP)
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- 2022
3. Rooting Formal Methods within Higher Education Curricula for Computer Science and Software Engineering -- A White Paper
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Cerone, Antonio, Roggenbach, Markus, Davenport, James, Denner, Casey, Farrell, Marie, Haveraaen, Magne, Moller, Faron, Koerner, Philipp, Krings, Sebastian, Olveczky, Peter, Schlingloff, Bernd-Holger, Shilov, Nikolay, and Zhumagambetov, Rustam
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Computer Science - Software Engineering - Abstract
This white paper argues that formal methods need to be better rooted in higher education curricula for computer science and software engineering programmes of study. To this end, it advocates (i) improved teaching of formal methods; (ii) systematic highlighting of formal methods within existing, `classical' computer science courses; and (iii) the inclusion of a compulsory formal methods course in computer science and software engineering curricula. These recommendations are based on the observations that (a) formal methods are an essential and cost-effective means to increase software quality; however (b) computer science and software engineering programmes typically fail to provide adequate training in formal methods; and thus (c) there is a lack of computer science graduates who are qualified to apply formal methods in industry. This white paper is the result of a collective effort by authors and participants of the 1st International Workshop on "Formal Methods, Fun for Everybody" which was held in Bergen, Norway, 2-3 December 2019. As such, it represents insights based on learning and teaching computer science and software engineering (with or without formal methods) at various universities across Europe.
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- 2020
4. Effectiveness of Annotation-Based Static Type Inference
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Wingen, Isabel and Körner, Philipp
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Computer Science - Programming Languages ,Computer Science - Logic in Computer Science - Abstract
Benefits of static type systems are well-known: they offer guarantees that no type error will occur during runtime and, inherently, inferred types serve as documentation on how functions are called. On the other hand, many type systems have to limit expressiveness of the language because, in general, it is undecidable whether a given program is correct regarding types. Another concern that was not addressed so far is that, for logic programming languages such as Prolog, it is impossible to distinguish between intended and unintended failure and, worse, intended and unintended success without additional annotations. In this paper, we elaborate on and discuss the aforementioned issues. As an alternative, we present a static type analysis which is based on plspec. Instead of ensuring full type-safety, we aim to statically identify type errors on a best-effort basis without limiting the expressiveness of Prolog programs. Finally, we evaluate our approach on real-world code featured in the SWI community packages and a large project implementing a model checker., Comment: 15 pages. Part of WFLP 2020 pre-proceedings
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- 2020
5. On the Performance of Bytecode Interpreters in Prolog
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Körner, Philipp, Schneider, David, and Leuschel, Michael
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Computer Science - Programming Languages - Abstract
The semantics and the recursive execution model of Prolog make it very natural to express language interpreters in form of AST (Abstract Syntax Tree) interpreters where the execution follows the tree representation of a program. An alternative implementation technique is that of bytecode interpreters. These interpreters transform the program into a compact and linear representation before evaluating it and are generally considered to be faster and to make better use of resources. In this paper, we discuss different ways to express the control flow of interpreters in Prolog and present several implementations of AST and bytecode interpreters. On a simple language designed for this purpose, we evaluate whether techniques best known from imperative languages are applicable in Prolog and how well they perform. Our ultimate goal is to assess which interpreter design in Prolog is the most efficient, as we intend to apply these results to a more complex language. However, we believe the analysis in this paper to be of more general interest., Comment: 15 pages. Part of WFLP 2020 pre-proceedings
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- 2020
6. A laboratory pilot study on voids in flowable bulk-fill composite restorations in bovine Class-II and endodontic access cavities after sonic vibration
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Körner, Philipp, Gerber, Sandra C., Gantner, Cindy, Hamza, Blend, Wegehaupt, Florian J., Attin, Thomas, and Deari, Shengjile
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- 2023
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7. Prolog Coding Guidelines: Status and Tool Support
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Nogatz, Falco, Körner, Philipp, and Krings, Sebastian
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Computer Science - Programming Languages ,Computer Science - Logic in Computer Science ,Computer Science - Software Engineering ,D.1.6 ,D.2.3 ,D.2.5 ,D.2.8 - Abstract
The importance of coding guidelines is generally accepted throughout developers of every programming language. Naturally, Prolog makes no exception. However, establishing coding guidelines is fraught with obstacles: Finding common ground on kind and selection of rules is matter of debate; once found, adhering to or enforcing rules is complicated as well, not least because of Prolog's flexible syntax without keywords. In this paper, we evaluate the status of coding guidelines in the Prolog community and discuss to what extent they can be automatically verified. We implemented a linter for Prolog and applied it to several packages to get a hold on the current state of the community., Comment: In Proceedings ICLP 2019, arXiv:1909.07646
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- 2019
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8. Measuring Coverage of Prolog Programs Using Mutation Testing
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Efremidis, Alexandros, Schmidt, Joshua, Krings, Sebastian, and Körner, Philipp
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Computer Science - Programming Languages ,Computer Science - Logic in Computer Science - Abstract
Testing is an important aspect in professional software development, both to avoid and identify bugs as well as to increase maintainability. However, increasing the number of tests beyond a reasonable amount hinders development progress. To decide on the completeness of a test suite, many approaches to assert test coverage have been suggested. Yet, frameworks for logic programs remain scarce. In this paper, we introduce a framework for Prolog programs measuring test coverage using mutations. We elaborate the main ideas of mutation testing and transfer them to logic programs. To do so, we discuss the usefulness of different mutations in the context of Prolog and empirically evaluate them in a new mutation testing framework on different examples., Comment: 16 pages, Accepted for presentation in WFLP 2018
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- 2018
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9. Effect of the toothbrush tuft arrangement and bristle stiffness on the abrasive dentin wear
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Hamza, Blend, Niedzwiecki, Maria, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian J.
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- 2022
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10. Integrating formal specifications into applications: the ProB Java API
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Körner, Philipp, Bendisposto, Jens, Dunkelau, Jannik, Krings, Sebastian, and Leuschel, Michael
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- 2021
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11. Symbolic Reachability Analysis of B through ProB and LTSmin
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Bendisposto, Jens, Koerner, Philipp, Leuschel, Michael, Meijer, Jeroen, van de Pol, Jaco, Treharne, Helen, and Whitefield, Jorden
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Computer Science - Software Engineering - Abstract
We present a symbolic reachability analysis approach for B that can provide a significant speedup over traditional explicit state model checking. The symbolic analysis is implemented by linking ProB to LTSmin, a high-performance language independent model checker. The link is achieved via LTSmin's PINS interface, allowing ProB to benefit from LTSmin's analysis algorithms, while only writing a few hundred lines of glue-code, along with a bridge between ProB and C using ZeroMQ. ProB supports model checking of several formal specification languages such as B, Event-B, Z and TLA. Our experiments are based on a wide variety of B-Method and Event-B models to demonstrate the efficiency of the new link. Among the tested categories are state space generation and deadlock detection; but action detection and invariant checking are also feasible in principle. In many cases we observe speedups of several orders of magnitude. We also compare the results with other approaches for improving model checking, such as partial order reduction or symmetry reduction. We thus provide a new scalable, symbolic analysis algorithm for the B-Method and Event-B, along with a platform to integrate other model checking improvements via LTSmin in the future.
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- 2016
12. Validation and real-life demonstration of ETCS hybrid level 3 principles using a formal B model
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Hansen, Dominik, Leuschel, Michael, Körner, Philipp, Krings, Sebastian, Naulin, Thomas, Nayeri, Nader, Schneider, David, and Skowron, Frank
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- 2020
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13. Effect of dentin pretreatment on the resulting abrasive dentin wear
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Hamza, Blend, Kazimi, Marina, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian Just
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- 2021
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14. Potential of different fluoride gels to prevent erosive tooth wear caused by gastroesophageal reflux
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Körner, Philipp, Georgis, Luca, Wiedemeier, Daniel B., Attin, Thomas, and Wegehaupt, Florian J.
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- 2021
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15. Correction to: Effect of dentin pretreatment on the resulting abrasive dentin wear
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Hamza, Blend, Kazimi, Marina, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian Just
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- 2021
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16. On Executing State-Based Specifications and Partial Order Reduction for High-Level Formalisms
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Körner, Philipp and Körner, Philipp
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- 2023
17. Effect of brushing force on the abrasive dentin wear using slurries with different abrasivity values
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Hamza, Blend, Martinola, Laura, Körner, Philipp, Gubler, Andrea, Attin, Thomas, Wegehaupt, Florian Just, University of Zurich, and Hamza, Blend
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3501 Dentistry (miscellaneous) ,Dentistry (miscellaneous) ,610 Medicine & health ,10067 Clinic for Orthodontics and Pediatric Dentistry - Abstract
The aim of this study was to investigate the resulting abrasive dentin wear using abrasive slurries with different RDA values and applying increasing brushing forces.Forty-five bovine incisors were randomly allocated in three groups (A, B, C, n = 15). One hundred and eighty dentin samples were prepared from these incisors and allocated to twelve groups (A1-A4, B1-B4, C1-C4; n = 15). The groups were subjected to a brushing cycle (120 strokes/min, 25 min) as follows: groups A1 to A4 with an abrasive slurry (RDA = 71) applying increasing brushing forces (1, 2, 3 and 4 N). Groups B1 to B4 were brushed using an abrasive slurry (RDA = 85) and C1 to C4 (RDA = 133) applying the same above-mentioned brushing forces. Abrasive dentin wear was recorded using a stylus profilometer and compared amongst the groups using robust models. Pairwise comparisons in each model were tested and corrected after Tukey's method (α = 0.05).Applying 1-N brushing force resulted in the same amount of abrasive dentin wear in all groups regardless of the abrasivity of the used slurry. Increasing the brushing force to 2 N resulted in statistically significantly higher abrasive wear in all groups. This increase in abrasive wear was much higher when the slurry with high abrasivity was used (RDA = 133) compared with the lower abrasive slurry (RDA = 71).The abrasivity of the used slurry does not add to the resulting abrasive wear when the brushing force is kept at 1 N. It seems better to advise and help the patients (showing signs of non-carious cervical lesions) calibrating their brushing force to 1 N, than only to advise them to use toothpastes with lower abrasivities.
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- 2023
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18. Erosive/Abrasive Enamel Wear While Using a Combination of Anti-Erosive Toothbrush/-Paste.
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Körner, Philipp, Inauen, Deborah S., Attin, Thomas, and Wegehaupt, Florian J.
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ANIMALS ,CATTLE ,DENTAL enamel ,DENTIFRICES ,TOOTH abrasion ,TOOTH care & hygiene ,TOOTH erosion - Abstract
Purpose: To investigate dental enamel wear caused by erosion and abrasion while using a combination of anti-erosive toothbrush/-paste.Materials and Methods: A total of 60 enamel specimens from bovine incisors were randomly assigned into five groups of 12 specimens each (G1-5, n = 12): (G1) control group (no treatment), (G2) standard medium toothbrush Paro M43 and standard toothpaste Elmex Caries Protection, (G3) standard medium toothbrush Paro M43 and anti-erosive toothpaste Elmex Protection Erosion, (G4) anti-erosive toothbrush Elmex Erosion Soft and standard toothpaste Elmex Caries Protection, (G5) anti-erosive toothbrush Elmex Erosion Soft and anti-erosive toothpaste Elmex Protection Erosion. Initially, surface baseline profiles were recorded using profilometry. In a total of 60 cycles, all specimens were exposed to hydrochloric acid (pH = 3) for 1 min, rinsed with tap water to stop the erosive attack and brushed according to the specific protocol of each group (15 brushing strokes per run). Enamel loss was determined by comparing the surface profiles before and after 60 cycles and the results were statistically analysed using analysis of variance (ANOVA).Results: The significantly highest loss of enamel was observed in the control group G1(1.4 ± 0.20 µm) (p < 0.001). G2 turned out to be the most abrasive toothbrush/-paste combination (1.12 ± 0.15 µm), G3 the least invasive (0.40 ± 0.04 µm) (p < 0.001, respectively).Conclusion: All combinations of the investigated toothbrushes/-pastes reduce erosive/abrasive enamel wear. However, the highest reduction was observed for the combination of anti-erosive toothpaste and standard toothbrush (G3). [ABSTRACT FROM AUTHOR]- Published
- 2020
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19. Validation of ERA5-Land temperature and relative humidity on four Peruvian glaciers using on-glacier observations
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Bonshoms, Martí, Ubeda Palenque, José, Liguori, Giovanni, Körner, Philipp, Navarro, Álvaro, Cruz, Rolando, Bonshoms, Martí, Ubeda Palenque, José, Liguori, Giovanni, Körner, Philipp, Navarro, Álvaro, and Cruz, Rolando
- Abstract
CRUE-CSIC (Acuerdos Transformativos 2022), Weather and climate conditions drive the evolution of tropical glaciers which play an important role as water reservoirs for Peruvian inhabitants in the arid coast and semi-arid Andean region. The scarcity of long-term high-quality observations over Peruvian glaciers has motivated the extensive use of reanalysis data to describe the climatic evolution of these glaciers. However, the representativeness and uncertainties of these reanalysis products over these glaciers are still poorly constrained. This study evaluates the ability of the ERA5-Land reanalysis (ERA5L) to reproduce hourly and monthly 2 m air temperature and relative humidity (T2m and Rh2m, respectively) over several Peruvian glaciers. We compared the ERA5L with data from four on-glacier automatic weather stations (AWS), whose hourly time series were completed with nearby stations, for the period January 2017 to December 2019. Results indicates a better performance of the reanalysis for T2m (r >0.80) than for Rh2m (∼0.4< r <∼0.6) in all four glaciers. Concerning the observations, both parameters show a daily cycle influenced by the presence of the glacier. This influence is more prominent during the dry months when the so-called glacier damping and cooling effects are stronger. On a monthly time scale, the ERA5L validation for both parameters are better in wet outer tropical sites (RMSE between ±0.2°C for T2m and between 3%–7% for Rh2m) rather than in dry outer tropical sites (RMSE between ±0.2°C for T2m and between 3%–7% for Rh2m). Among all sites considered in the study, the Rh2m bias is the highest in the Cavalca glacier (correlation of 0.81; RMSE 13%, MAE 11% and bias 8.3%) and the lowest in Artesonraju glacier (correlation of 0.96; RMSE 3%; MAE 2.3% and bias — 0.8%). Based on certain considerations outlined in this paper, it is appropriate to use ERA5L to characterize T2m and Rh2m conditions on Peruvian glaciers, particularly in the wet outer tropics., Ministerio de Ciencia e Innovación (MICINN), Depto. de Geografía, Fac. de Geografía e Historia, TRUE, pub
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- 2022
20. Klima-Referenzdatensatz Sachsen 1961-2020: Erzeugung eines lückenlosen, stationsbasierten und rasterbasierten KlimaReferenzdatensatzes für Sachsen für den Zeitraum 1961 bis 2020
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Franke, Johannes, Körner, Philipp, Vorobevskii, Ivan, Kronenberg, Rico, Homoudi, Ahmed, Franke, Johannes, Körner, Philipp, Vorobevskii, Ivan, Kronenberg, Rico, and Homoudi, Ahmed
- Abstract
Die Schriftenreihe informiert über den “Klima-Referenzdatensatz Sachsen, 1961-2020” als Basis für ein qualitativ gesichertes und flächendifferenziertes Klima- und Klimafolgen-Monitoring in Sachsen. Der Datensatz umfasst stations- und rasterbasierte Teildatensätze. Er basiert auf lückenlosen Zeitreihen mit Tageswerten für meteorologische Elemente an Messstationen aus nationalen (D, CZ, PL) und landeseigenen Messnetzen (SN) im Datengebiet des “Mitteldeutschen Kernensembles, 1961-2100”. Als erste Anwendung erfolgte eine Fortschreibung der “Starkregen-Analyse Sachsen” im Zeitraum 1961-2020. Die Erweiterung der Datenbasis um 5 Jahre zur Vorgängerstudie zeigt eine Verstärkung der Änderungssignale. Zusätzlich erfolgte eine Nebenrechnung nicht-registrierter Niederschlagsgewinne durch Nebelauskämmung. Das im Rahmen des Projektes erzeugte Material ist über ReKIS (www.rekis.org) frei zugänglich. Die Veröffentlichung richtet sich an regionale Akteure in der Fachverwaltung, Planungsbüros u.a. sowie an die breite Öffentlichkeit. Redaktionsschluss: 01.07.2022
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- 2022
21. Radarbasierte Niederschlagsdaten 2001-2020: Radarbasierte Niederschlagsdaten im Zeitraum 2001-2020: Beschaffung, Aufbereitung und Bereitstellung im ReKIS
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Franke, Johannes, Körner, Philipp, Franke, Johannes, and Körner, Philipp
- Abstract
Die Broschüre informiert über die Aufbereitung radarbasierter Niederschlagsdaten. Das hochaufgelöste RADOLAN-Produkt des Deutschen Wetterdienstes (räumlich: 1km, zeitlich: 1h) liegt nach der Aufbereitung lückenlos vor für den Zeitraum 2001 bis 2020 auf dem RaKliDa-konformen Gitter (Lagebezug: GK4) für das ReKIS-Datengebiet (Sachsen, Sachsen-Anhalt, Thüringen). Der Datensatz und die Produktbeschreibung richteten sich an Fachpublikum und steht über das Regionale Klima-Informationssystem ReKIS (www.rekis.org) frei zur Verfügung. Redaktionsschluss: 12.01.2022
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- 2022
22. Effect of the toothbrush tuft arrangement and bristle stiffness on the abrasive dentin wear
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Hamza, Blend; https://orcid.org/0000-0003-0493-2553, Niedzwiecki, Maria, Körner, Philipp; https://orcid.org/0000-0002-9254-7112, Attin, Thomas; https://orcid.org/0000-0002-6141-1263, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Hamza, Blend; https://orcid.org/0000-0003-0493-2553, Niedzwiecki, Maria, Körner, Philipp; https://orcid.org/0000-0002-9254-7112, Attin, Thomas; https://orcid.org/0000-0002-6141-1263, and Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561
- Abstract
The geometrical properties of toothbrushes play a role in developing abrasive tooth wear and non-carious cervical lesions. This study investigated the interplay between the toothbrush tuft arrangement (crossed vs. parallel) and bristle stiffness (soft vs. medium) on the abrasive dentin wear using three slurries with different levels of abrasivity (RDA: 67, 121 and 174). Twelve groups of bovine dentin samples (n = 20) were brushed with a combination of the aforementioned variables. Abrasive dentin wear was recorded with a profilometer and the resulting abrasive wear of each group was calculated and compared with each other using two-way ANOVA and pairwise tests. Toothbrushes with parallel tuft arrangement caused statistically significantly higher dentin wear compared to crossed tuft arrangement, regardless of the abrasivity level of the used slurry and the bristle stiffness. Soft crossed tuft toothbrushes caused statistically significantly higher abrasive dentin wear than medium crossed tuft toothbrushes, while soft and medium parallel tuft toothbrushes caused the same amounts of dentin wear, regardless of the RDA value of the used slurry. These results could be helpful for dentists and dental hygienists when advising patients. Crossed tuft toothbrushes could be a less-abrasive choice in comparison to parallel tuft toothbrushes.
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- 2022
23. A Verified Low-Level Implementation of the Adaptive Exterior Light and Speed Control System
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Krings, Sebastian, Körner, Philipp, Dunkelau, Jannik, and Rutenkolk, Chris
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Article - Abstract
In this article, we present an approach to the ABZ 2020 case study, that differs from the ones usually presented at ABZ: Rather than using a (correct-by-construction) approach following a formal method, we use MISRA C for a low-level implementation instead. We strictly adhere to test-driven development for validation, and only afterwards apply model checking using CBMC for verification. In consequence, our realization of the ABZ case study can serve as a baseline reference for comparison, allowing to assess the benefit provided by the various formal modeling languages, methods and tools.
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- 2020
24. Towards a Shared Specification Repository
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Körner, Philipp, Leuschel, Michael, and Dunkelau, Jannik
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Article - Abstract
Many formal methods research communities lack a shared set of benchmarks. As a result, many research articles in the past have evaluated new techniques on specifications that are specifically tailored to the problem or not publicly available. While this is great for proving the concept in question, it does not offer any insights on how it performs on real-world examples. Additionally, with machine learning techniques gaining more popularity, a larger set of public specifications is required. In this paper, we present our public set of B machines and urge contribution. As we think this to be an issue in other communities in scope of the ABZ as well, we are also interested in specifications expressed in other formalisms, for example Alloy, TLA\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^{+}$$\end{document} or Z.
- Published
- 2020
25. Effect of tapered-end and round-end bristles on the abrasive dentine wear applying increasing brushing forces
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Hamza, Blend, Svellenti, Leonardo, Körner, Philipp, Attin, Thomas, Wegehaupt, Florian J, University of Zurich, and Hamza, Blend
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Toothbrushing ,non ,Analysis of Variance ,Abrasive dentine wear ,tapered ,610 Medicine & health ,General Medicine ,Equipment Design ,10067 Clinic for Orthodontics and Pediatric Dentistry ,3500 General Dentistry ,round ,toothbrush ,carious cervical lesion ,Tooth Abrasion ,end bristles ,10066 Clinic of Conservative and Preventive Dentistry ,Dentin ,Animals ,Humans ,Cattle ,General Dentistry - Abstract
To investigate the effect of toothbrush bristles end configuration on the abrasive dentine wear at different brushing forces.One hundred and sixty bovine dentine samples were randomized into eight groups (Brushing with tapered-end bristles resulted in statistically significantly less abrasive dentine wear than round-end bristles regardless of the applied brushing force (1 N: 4.4 ± 1.5 vs. 7.7 ± 2.0 µm; 2 N: 7.7 ± 2.1 vs. 12.2 ± 2.7 µm; 3 N: 11.3 ± 2.6 vs. 19.4 ± 3.7 µm; 4 N: 11.2 ± 2.1 vs. 25.3 ± 4.8 µm). The interaction between bristle configuration and brushing force was statistically significantly (Tapered-end toothbrushes might be a safer choice for patients, especially when showing signs of non-carious cervical lesion. However, other toothbrush properties should also be considered.
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- 2022
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26. Klima-Referenzdatensatz Sachsen 1961-2020: Erzeugung eines lückenlosen, stationsbasierten und rasterbasierten KlimaReferenzdatensatzes für Sachsen für den Zeitraum 1961 bis 2020
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Körner, Philipp, Vorobevskii, Ivan, Kronenberg, Rico, Homoudi, Ahmed, and Franke, Johannes
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Sachsen, Klima, Monitoring ,ddc:551 ,Sachsen ,Klima ,Monitoring ,Geschichte 1961-2015 - Abstract
Die Schriftenreihe informiert über den “Klima-Referenzdatensatz Sachsen, 1961-2020” als Basis für ein qualitativ gesichertes und flächendifferenziertes Klima- und Klimafolgen-Monitoring in Sachsen. Der Datensatz umfasst stations- und rasterbasierte Teildatensätze. Er basiert auf lückenlosen Zeitreihen mit Tageswerten für meteorologische Elemente an Messstationen aus nationalen (D, CZ, PL) und landeseigenen Messnetzen (SN) im Datengebiet des “Mitteldeutschen Kernensembles, 1961-2100”. Als erste Anwendung erfolgte eine Fortschreibung der “Starkregen-Analyse Sachsen” im Zeitraum 1961-2020. Die Erweiterung der Datenbasis um 5 Jahre zur Vorgängerstudie zeigt eine Verstärkung der Änderungssignale. Zusätzlich erfolgte eine Nebenrechnung nicht-registrierter Niederschlagsgewinne durch Nebelauskämmung. Das im Rahmen des Projektes erzeugte Material ist über ReKIS (www.rekis.org) frei zugänglich. Die Veröffentlichung richtet sich an regionale Akteure in der Fachverwaltung, Planungsbüros u.a. sowie an die breite Öffentlichkeit. Redaktionsschluss: 01.07.2022
- Published
- 2022
27. Radarbasierte Niederschlagsdaten 2001-2020: Radarbasierte Niederschlagsdaten im Zeitraum 2001-2020: Beschaffung, Aufbereitung und Bereitstellung im ReKIS
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Körner, Philipp and Franke, Johannes
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ddc:333.7 ,Sachsen, Sachsen-Anhalt, Thüringen, Niederschlagsdaten, ReKIS ,Sachsen ,Sachsen-Anhalt ,Thüringen ,Umweltinformationssystem ,Niederschlagsmenge ,Geschichte 2001-2020 ,Radarmeteorologie ,Niederschlagsmessung - Abstract
Die Broschüre informiert über die Aufbereitung radarbasierter Niederschlagsdaten. Das hochaufgelöste RADOLAN-Produkt des Deutschen Wetterdienstes (räumlich: 1km, zeitlich: 1h) liegt nach der Aufbereitung lückenlos vor für den Zeitraum 2001 bis 2020 auf dem RaKliDa-konformen Gitter (Lagebezug: GK4) für das ReKIS-Datengebiet (Sachsen, Sachsen-Anhalt, Thüringen). Der Datensatz und die Produktbeschreibung richteten sich an Fachpublikum und steht über das Regionale Klima-Informationssystem ReKIS (www.rekis.org) frei zur Verfügung. Redaktionsschluss: 12.01.2022
- Published
- 2022
28. OralDisk: A Chair-Side Compatible Molecular Platform Using Whole Saliva for Monitoring Oral Health at the Dental Practice
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Baumgartner, Desirée, Johannsen, Benita, Specht, Mara, Lüddecke, Jan, Rombach, Markus, Hin, Sebastian, Paust, Nils, von Stetten, Felix, Zengerle, Roland, Herz, Christopher, Peham, Johannes R, Paqué, Pune N, Attin, Thomas, Jenzer, Joël S, Körner, Philipp, Schmidlin, Patrick R, Thurnheer, Thomas, Wegehaupt, Florian J, Kaman, Wendy E, Stubbs, Andrew, Hays, John P, Rusu, Viorel, Michie, Alex, Binsl, Thomas, Stejskal, David, Karpíšek, Michal, Bao, Kai, Bostanci, Nagihan, Belibasakis, Georgios N, Mitsakakis, Konstantinos, University of Zurich, Baumgartner, Desirée, Mitsakakis, Konstantinos, Medical Microbiology & Infectious Diseases, Pathology, and Oral Biochemistry
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Clinical Biochemistry ,610 Medicine & health ,SDG 10 - Reduced Inequalities ,General Medicine ,Dental Caries ,Microfluidic Analytical Techniques ,1308 Clinical Biochemistry ,Article ,treatment monitoring ,stomatognathic diseases ,stomatognathic system ,SDG 3 - Good Health and Well-being ,10066 Clinic of Conservative and Preventive Dentistry ,saliva diagnostics ,Humans ,oral health ,Saliva ,dental practice ,point-of-care diagnostics ,periodontitis ,TP248.13-248.65 ,caries ,Biotechnology - Abstract
Periodontitis and dental caries are two major bacterially induced, non-communicable diseases that cause the deterioration of oral health, with implications in patients’ general health. Early, precise diagnosis and personalized monitoring are essential for the efficient prevention and management of these diseases. Here, we present a disk-shaped microfluidic platform (OralDisk) compatible with chair-side use that enables analysis of non-invasively collected whole saliva samples and molecular-based detection of ten bacteria: seven periodontitis-associated (Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Fusobacterium nucleatum, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola) and three caries-associated (oral Lactobacilli, Streptococcus mutans, Streptococcus sobrinus). Each OralDisk test required 400 µL of homogenized whole saliva. The automated workflow included bacterial DNA extraction, purification and hydrolysis probe real-time PCR detection of the target pathogens. All reagents were pre-stored within the disk and sample-to-answer processing took <, 3 h using a compact, customized processing device. A technical feasibility study (25 OralDisks) was conducted using samples from healthy, periodontitis and caries patients. The comparison of the OralDisk with a lab-based reference method revealed a ~90% agreement amongst targets detected as positive and negative. This shows the OralDisk’s potential and suitability for inclusion in larger prospective implementation studies in dental care settings.
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- 2021
- Full Text
- View/download PDF
29. Enamel Softening Can Be Reduced by Rinsing with a Fluoride Mouthwash Before Dental Erosion but Not with a Calcium Solution
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Körner, Philipp, Nguyen, Thanh Phong, Hamza, Blend, Attin, Thomas, Wegehaupt, Florian J, and University of Zurich
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3503 Dental Hygiene ,10066 Clinic of Conservative and Preventive Dentistry ,610 Medicine & health ,10067 Clinic for Orthodontics and Pediatric Dentistry - Published
- 2021
- Full Text
- View/download PDF
30. Fog and fog deposition: A novel approach to estimate the occurrence of fog and the amount of fog deposition: a case study for Germany
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Körner, Philipp, Bernhofer, Christian, Klemm, Otto, Schütze, Niels, and Technische Universität Dresden
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Nebel, Lückenfüllen, Flüssigwassergehalt, gradient boosting ,ddc:550 ,fog, gap filling, liquid water content, gradient boosting - Abstract
This thesis is written as a cumulative dissertation. It presents methods and results which contribute to an improved understanding of the spatio-temporal variability of fog and fog deposition. The questions to be answered are: When is there how much fog, and where and how much fog is deposited on the vegetation as fog precipitation? Freely available data sets serve as a database. The meteorological input data are obtained from the Climate Data Center (CDC) of the German Meteorological Service (DWD). Station data for temperature, relative humidity and wind speed in hourly resolution are used. In addition, visibility data are used for validation purposes. Furthermore, Global Forest Heights (GFH) data from the National Aeronautics and Space Administration (NASA) are used as vegetation height data. The data from NASA’s Shuttle Radar Topography Mission (SRTM) is used as a digital elevation model. The first publication deals with gap filling and data compression for further calculations. This is necessary since the station density for hourly data is relatively low, especially before the 2000s. In addition, there are more frequent gaps in hourly data than in, for instance, daily data, which can thus be filled. It is shown that gradient boosting (gb) enables high quality gap filling in a short computing time. The second publication deals with the determination of the fog, especially with the liquid water content (lwc). Here the focus is on the correction of measurement errors of the relative humidity as well as methods of spatial interpolation are dealt with. The resulting lwc data for Germany with a temporal resolution of one hour and a spatial resolution of one kilometre, are validated against measured lwc data as well as visibility data of the DWD. The last publication uses the data and methods of the two previous publications. The vegetation and wind speed data are also used to determine fog precipitation from the lwc data. This is validated using data from other publications and water balance calculations. In addition to the measured precipitation, the fog precipitation data are used as an input variable for the modelling. This is also one of the possible applications: To determine precipitation from fog, which is not recorded by standard measuring methods, and thus to make water balance modelling more realistic.:1 MOTIVATION 6 2 PROBLEM DEFINITION AND TARGET SETTING 6 3 STRUCTURE 7 4 MODEL LIMITS 9 5 PUBLICATIONS 9 6 OUTLOOK 29
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- 2021
31. Effect of Caries Infiltrant on Margin Integrity of Composite Fillings Placed Adjacent to Demineralised Primary Enamel
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Attin, Rengin, Rüedi, Nathalie, Tauböck, Tobias T, Körner, Philipp, Wiedemeier, Daniel, Attin, Thomas, and University of Zurich
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10066 Clinic of Conservative and Preventive Dentistry ,610 Medicine & health ,10067 Clinic for Orthodontics and Pediatric Dentistry - Published
- 2021
- Full Text
- View/download PDF
32. Fog and fog deposition: A novel approach to estimate the occurrence of fog and the amount of fog deposition: a case study for Germany
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Bernhofer, Christian, Klemm, Otto, Schütze, Niels, Technische Universität Dresden, Körner, Philipp, Bernhofer, Christian, Klemm, Otto, Schütze, Niels, Technische Universität Dresden, and Körner, Philipp
- Abstract
This thesis is written as a cumulative dissertation. It presents methods and results which contribute to an improved understanding of the spatio-temporal variability of fog and fog deposition. The questions to be answered are: When is there how much fog, and where and how much fog is deposited on the vegetation as fog precipitation? Freely available data sets serve as a database. The meteorological input data are obtained from the Climate Data Center (CDC) of the German Meteorological Service (DWD). Station data for temperature, relative humidity and wind speed in hourly resolution are used. In addition, visibility data are used for validation purposes. Furthermore, Global Forest Heights (GFH) data from the National Aeronautics and Space Administration (NASA) are used as vegetation height data. The data from NASA’s Shuttle Radar Topography Mission (SRTM) is used as a digital elevation model. The first publication deals with gap filling and data compression for further calculations. This is necessary since the station density for hourly data is relatively low, especially before the 2000s. In addition, there are more frequent gaps in hourly data than in, for instance, daily data, which can thus be filled. It is shown that gradient boosting (gb) enables high quality gap filling in a short computing time. The second publication deals with the determination of the fog, especially with the liquid water content (lwc). Here the focus is on the correction of measurement errors of the relative humidity as well as methods of spatial interpolation are dealt with. The resulting lwc data for Germany with a temporal resolution of one hour and a spatial resolution of one kilometre, are validated against measured lwc data as well as visibility data of the DWD. The last publication uses the data and methods of the two previous publications. The vegetation and wind speed data are also used to determine fog precipitation from the lwc data. This is validated using data from other public
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- 2021
33. Salivary biomarkers for dental caries detection and personalized monitoring
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Paqué, Pune N., Herz, Christopher, Wiedemeier, Daniel B., Mitsakakis, Konstantinos, Attin, Thomas, Bao, Kai, Belibasakis, Georgios N., Hays, John P., Jenzer, Joël S., Kaman, Wendy E., Karpíšek, Michal, Körner, Philipp, Peham, Johannes R., Schmidlin, Patrick R., Thurnheer, Thomas, Wegehaupt, Florian J., Bostanci, Nagihan, Paqué, Pune N., Herz, Christopher, Wiedemeier, Daniel B., Mitsakakis, Konstantinos, Attin, Thomas, Bao, Kai, Belibasakis, Georgios N., Hays, John P., Jenzer, Joël S., Kaman, Wendy E., Karpíšek, Michal, Körner, Philipp, Peham, Johannes R., Schmidlin, Patrick R., Thurnheer, Thomas, Wegehaupt, Florian J., and Bostanci, Nagihan
- Abstract
This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries-and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis revealed four biomarkers (IL-4, IL-13, IL-2-RA, and eotaxin/CCL11) to be of high importance for the correct depiction of caries in 37 of 38 patients. The RF model was then used to classify 10 subjects (five caries-/gingivitis-free and five with caries), who were followed over a period of six months. The results were compared to the clinical assessments of dental specialists, revealing a high correlation between the RF prediction and the clinical classification. Due to the superior sensitivity of the RF model, there was a divergence in the prediction of two caries and four caries-/gingivitis-free subjects. These findings suggest IL-4, IL-13, IL-2-RA, and eotaxin/CCL11 as potential salivary biomarkers for identifying noninvasive caries. Furthermore, we suggest a potential association between JAK/STAT signaling and dental caries onset and progression.
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- 2021
34. Oraldisk:A chair-side compatible molecular platform using whole saliva for monitoring oral health at the dental practice
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Baumgartner, Desirée, Johannsen, Benita, Specht, Mara, Lüddecke, Jan, Rombach, Markus, Hin, Sebastian, Paust, Nils, von Stetten, Felix, Zengerle, Roland, Herz, Christopher, Peham, Johannes R., Paqué, Pune N., Attin, Thomas, Jenzer, Joël S., Körner, Philipp, Schmidlin, Patrick R., Thurnheer, Thomas, Wegehaupt, Florian J., Kaman, Wendy E., Stubbs, Andrew, Hays, John P., Rusu, Viorel, Michie, Alex, Binsl, Thomas, Stejskal, David, Karpíšek, Michal, Bao, Kai, Bostanci, Nagihan, Belibasakis, Georgios N., Mitsakakis, Konstantinos, Baumgartner, Desirée, Johannsen, Benita, Specht, Mara, Lüddecke, Jan, Rombach, Markus, Hin, Sebastian, Paust, Nils, von Stetten, Felix, Zengerle, Roland, Herz, Christopher, Peham, Johannes R., Paqué, Pune N., Attin, Thomas, Jenzer, Joël S., Körner, Philipp, Schmidlin, Patrick R., Thurnheer, Thomas, Wegehaupt, Florian J., Kaman, Wendy E., Stubbs, Andrew, Hays, John P., Rusu, Viorel, Michie, Alex, Binsl, Thomas, Stejskal, David, Karpíšek, Michal, Bao, Kai, Bostanci, Nagihan, Belibasakis, Georgios N., and Mitsakakis, Konstantinos
- Abstract
Periodontitis and dental caries are two major bacterially induced, non-communicable diseases that cause the deterioration of oral health, with implications in patients’ general health. Early, precise diagnosis and personalized monitoring are essential for the efficient prevention and management of these diseases. Here, we present a disk-shaped microfluidic platform (OralDisk) compatible with chair-side use that enables analysis of non-invasively collected whole saliva samples and molecular-based detection of ten bacteria: seven periodontitis-associated (Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Fusobacterium nucleatum, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola) and three caries-associated (oral Lactobacilli, Streptococcus mutans, Streptococcus sobrinus). Each OralDisk test required 400 µL of homogenized whole saliva. The automated workflow included bacterial DNA extraction, purification and hydrolysis probe real-time PCR detection of the target pathogens. All reagents were pre-stored within the disk and sample-to-answer processing took < 3 h using a compact, customized processing device. A technical feasibility study (25 OralDisks) was conducted using samples from healthy, periodontitis and caries patients. The comparison of the OralDisk with a lab-based reference method revealed a ~90% agreement amongst targets detected as positive and negative. This shows the OralDisk’s potential and suitability for inclusion in larger prospective implementation studies in dental care settings.
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- 2021
35. Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring
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Paqué, Pune N; https://orcid.org/0000-0002-4219-3395, Herz, Christopher, Wiedemeier, Daniel B; https://orcid.org/0000-0001-8997-700X, Mitsakakis, Konstantinos; https://orcid.org/0000-0002-3287-9123, Attin, Thomas, Bao, Kai, Belibasakis, Georgios N; https://orcid.org/0000-0002-8164-0653, Hays, John P, Jenzer, Joël S; https://orcid.org/0000-0002-0590-6894, Kaman, Wendy E, Karpíšek, Michal, Körner, Philipp, Peham, Johannes R, Schmidlin, Patrick R; https://orcid.org/0000-0002-1377-0325, Thurnheer, Thomas; https://orcid.org/0000-0002-8615-8209, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Bostanci, Nagihan, Paqué, Pune N; https://orcid.org/0000-0002-4219-3395, Herz, Christopher, Wiedemeier, Daniel B; https://orcid.org/0000-0001-8997-700X, Mitsakakis, Konstantinos; https://orcid.org/0000-0002-3287-9123, Attin, Thomas, Bao, Kai, Belibasakis, Georgios N; https://orcid.org/0000-0002-8164-0653, Hays, John P, Jenzer, Joël S; https://orcid.org/0000-0002-0590-6894, Kaman, Wendy E, Karpíšek, Michal, Körner, Philipp, Peham, Johannes R, Schmidlin, Patrick R; https://orcid.org/0000-0002-1377-0325, Thurnheer, Thomas; https://orcid.org/0000-0002-8615-8209, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, and Bostanci, Nagihan
- Abstract
This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis revealed four biomarkers (IL-4, IL-13, IL-2-RA, and eotaxin/CCL11) to be of high importance for the correct depiction of caries in 37 of 38 patients. The RF model was then used to classify 10 subjects (five caries-/gingivitis-free and five with caries), who were followed over a period of six months. The results were compared to the clinical assessments of dental specialists, revealing a high correlation between the RF prediction and the clinical classification. Due to the superior sensitivity of the RF model, there was a divergence in the prediction of two caries and four caries-/gingivitis-free subjects. These findings suggest IL-4, IL-13, IL-2-RA, and eotaxin/CCL11 as potential salivary biomarkers for identifying noninvasive caries. Furthermore, we suggest a potential association between JAK/STAT signaling and dental caries onset and progression.
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- 2021
36. Einschätzung von Zahnärzten zu vermuteten Gründen für das Scheitern von Kompositfüllungen mittels Adhäsivtechnik
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Körner, Philipp; https://orcid.org/0000-0002-9254-7112, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Attin, Thomas; https://orcid.org/0000-0002-6141-1263, Körner, Philipp; https://orcid.org/0000-0002-9254-7112, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, and Attin, Thomas; https://orcid.org/0000-0002-6141-1263
- Abstract
Aim of this study was to get an overview of what dentists estimate to be the reason for failure of adhesive composite restorations and to gain knowledge about potential future foci for targeted further education. Therefore, a survey about the fabrication of composite restorations was conducted in the course of seven dental conferences with the main topic tooth-prevention. A total of 577 dentists participated in the survey. The most often called estimated factor for failure of composite restorations was the "dentist" (70.7%), followed by "indication" (32.2%), "material" (8.5%) and "patient" (8.1%). Participants estimated insufficient drying and fluid management (67.9%), incorrect application of the adhesive system (41.8%), insufficient lightpolymerisation (31.2%) and errors in incremental technique (27.6%) to be the main mistakes. The participating dentists claimed to attach great importance to careful drying and fluid management (60.8%), thorough adhesive application (37.3%), adequate incremental technique (32.6%) and sufficient lightpolymerisation (28.8%) while placing their own restorations. According to the survey participants, the treating dentist has the greatest influence on the quality and longevity of composite restorations. Drying and fluid management was the most often called estimated reason for failure but at the same time the step which is given the greatest caution. Keywords: Adhäsivtechnik; Fortbildung; Kompositfüllung; Umfrage; Zahnarzt.
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- 2021
37. Toothpastes with Enzymes Support Gum Health and Reduce Plaque Formation
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Paqué, Pune N; https://orcid.org/0000-0002-4219-3395, Schmidlin, Patrick R; https://orcid.org/0000-0002-1377-0325, Wiedemeier, Daniel B, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Burrer, Phoebe D, Körner, Philipp, Deari, Shengjile, Sciotti, Michel-Angelo, Attin, Thomas, Paqué, Pune N; https://orcid.org/0000-0002-4219-3395, Schmidlin, Patrick R; https://orcid.org/0000-0002-1377-0325, Wiedemeier, Daniel B, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Burrer, Phoebe D, Körner, Philipp, Deari, Shengjile, Sciotti, Michel-Angelo, and Attin, Thomas
- Abstract
Enzymes in toothpastes can support host immune responses, and thus maintain oral health. This study aimed to investigate gingival health and the plaque-reducing effects of enzyme-containing toothpastes. A laboratory study tested the antimicrobial potential of different enzyme-containing toothpaste formulations. Two promising formulations (enzyme-containing toothpastes with glucose oxidase and D-glucose with (C+) and without Citrox (C-) Citrox) were investigated in a clinical crossover trial (two slurries: sodium lauryl sulfate-containing (SLS), a toothpaste without SLS (reference), and water). Subjects (n = 20) abstained from toothbrushing for four days and rinsed with a toothpaste slurry. Bleeding on probing (BOP) and plaque indices (PI) were measured. A mixed linear model was used to statistically compare the slurries with respect to BOP and PI change. The in vitro bacterial growth-inhibiting evaluation showed the best results for SLS, followed by C+ and C-. The change in BOP and PI exhibited statistically significant differences to water rinsing (BOP; PI changes in % points (difference of the baseline and post-rinse values: water = 8.8%; 90.0%; C+ = -1.4%; 80.4%; SLS = 1.5%; 72.1%; reference = 0.8%; 77.5%; C- = -1.8%; 75.1%). All slurries exhibited anti-gingivitis and anti-plaque effects, resulting in a prophylactic benefit for limited-access regions during brushing.
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- 2021
38. Effect of a sonic toothbrush on the abrasive dentine wear using toothpastes with different abrasivity values
- Author
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Hamza, Blend; https://orcid.org/0000-0003-0493-2553, Uka, Entoni, Körner, Philipp; https://orcid.org/0000-0002-9254-7112, Attin, Thomas; https://orcid.org/0000-0002-6141-1263, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Hamza, Blend; https://orcid.org/0000-0003-0493-2553, Uka, Entoni, Körner, Philipp; https://orcid.org/0000-0002-9254-7112, Attin, Thomas; https://orcid.org/0000-0002-6141-1263, and Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561
- Abstract
OBJECTIVE: This in vitro study aimed to investigate the effect of a sonic toothbrush on the resulting abrasive dentine wear using toothpastes with different abrasivities compared to the use of a manual toothbrush. METHODS: Ninety-six bovine dentine samples were divided into six groups and subjected to a brushing sequence (sonic: 20 min, 0.9 N, 10 strokes/min; manual: 20 min, 1.6 N, 60 strokes/min) as follows: group 1: Elmex Sensitive Plus (RDA = 28) + manual toothbrush; group 2: Elmex Sensitive + sonic toothbrush; group 3: Elmex Kariesschutz (RDA = 65) + manual toothbrush; group 4: Elmex Kariesschutz +sonic toothbrush; group 5: Colgate Total Original (RDA = 121) + manual toothbrush; and group 6: Colgate Total Original +sonic toothbrush. The abrasive dentine wear was measured profilometrically. RESULTS: The median (IQR) abrasive dentine wear was as follows: Elmex Sensitive Plus (manual toothbrush: 2.7 µm (0.8), sonic toothbrush: 3.1 µm (1.9)); Elmex Kariesschutz (manual toothbrush: 4.9 µm (1.4), sonic toothbrush: 6.4 µm (2.1)); and Colgate Total Original (manual toothbrush: 5.2 µm (1.1), sonic toothbrush: 9.0 µm (3.1)). Differences in dentine wear between sonic and manual toothbrushes were statistically significant only in the groups brushed with Elmex Kariesschutz and Colgate Total Original (p ≤ 0.05). CONCLUSION: Brushing with a sonic toothbrush could result in a higher abrasive dentine wear compared to manual toothbrush when combined with toothpastes with high abrasivity values.
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- 2021
39. Green Tea Extract Reduces the Erosive Dentine Wear Caused by Energy Drinks In Vitro
- Author
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Hamza, Blend; https://orcid.org/0000-0003-0493-2553, Rojas, Sheila Antonella Paucar, Körner, Philipp; https://orcid.org/0000-0002-9254-7112, Attin, Thomas; https://orcid.org/0000-0002-6141-1263, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Hamza, Blend; https://orcid.org/0000-0003-0493-2553, Rojas, Sheila Antonella Paucar, Körner, Philipp; https://orcid.org/0000-0002-9254-7112, Attin, Thomas; https://orcid.org/0000-0002-6141-1263, and Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561
- Abstract
PURPOSE: To investigate the effect of energy drinks supplementation with green tea extract on the erosive dentine wear. MATERIALS AND METHODS: Six groups of bovine dentine samples (n = 15) were subjected to four cycles erosive attacks (10 min, 25 °C) and remineralisation (artificial saliva, 60 min, 37°C) using the following formulas: tap water; green tea extract; Red Bull; Red Bull supplemented with green tea extract; Red Bull Light; Red Bull Light supplemented with green tea extract. The erosive dentine wear - ie, the irreversible dentine loss - was measured using a stylus profilometer (µm, accuracy = 40 nm). RESULTS: Median and interquartile range (IQR) of erosive dentine wear for the tested energy drinks before and after the supplementation with green tea extract were calculated as follows: Red Bull (before: 3.3 µm (1.0)); after: 1.2 µm (0.6)); Red Bull Light (before: 3.3 µm (0.9)); after: 2.0 µm (0.4)). The difference between the groups before and after the supplementation was statistically significant (P ˂0.05). The erosive dentine wear for the tap water group was calculated at 0.4 µm (0.6) and for the green tea extract group at -1.0 µm (1.3). CONCLUSIONS: Supplementation of energy drinks with green tea extract could reduce the erosive dentine wear caused by energy drink in vitro.
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- 2021
40. SPEED METAL.
- Author
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Eguiara, J. I. and Körner, Philipp
- Published
- 2023
41. Microbial Analysis of Saliva to Identify Oral Diseases Using a Point-of-Care Compatible qPCR Assay
- Author
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Paqué, Pune N; https://orcid.org/0000-0002-4219-3395, Herz, Christopher, Jenzer, Joël S; https://orcid.org/0000-0002-0590-6894, Wiedemeier, Daniel B; https://orcid.org/0000-0001-8997-700X, Attin, Thomas, Bostanci, Nagihan, Belibasakis, Georgios N; https://orcid.org/0000-0002-8164-0653, Bao, Kai, Körner, Philipp, Fritz, Tanja, Prinz, Julia; https://orcid.org/0000-0001-9996-7307, Schmidlin, Patrick R; https://orcid.org/0000-0002-1377-0325, Thurnheer, Thomas; https://orcid.org/0000-0002-8615-8209, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Mitsakakis, Konstantinos; https://orcid.org/0000-0002-3287-9123, Peham, Johannes R, Paqué, Pune N; https://orcid.org/0000-0002-4219-3395, Herz, Christopher, Jenzer, Joël S; https://orcid.org/0000-0002-0590-6894, Wiedemeier, Daniel B; https://orcid.org/0000-0001-8997-700X, Attin, Thomas, Bostanci, Nagihan, Belibasakis, Georgios N; https://orcid.org/0000-0002-8164-0653, Bao, Kai, Körner, Philipp, Fritz, Tanja, Prinz, Julia; https://orcid.org/0000-0001-9996-7307, Schmidlin, Patrick R; https://orcid.org/0000-0002-1377-0325, Thurnheer, Thomas; https://orcid.org/0000-0002-8615-8209, Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561, Mitsakakis, Konstantinos; https://orcid.org/0000-0002-3287-9123, and Peham, Johannes R
- Abstract
Oral health is maintained by a healthy microbiome, which can be monitored by state-of-the art diagnostics. Therefore, this study evaluated the presence and quantity of ten oral disease-associated taxa (P. gingivalis, T. forsythia, T. denticola, F. nucleatum, C. rectus, P. intermedia, A. actinomycetemcomitans, S. mutans, S. sobrinus, oral associated Lactobacilli) in saliva and their clinical status association in 214 individuals. Upon clinical examination, study subjects were grouped into healthy, caries and periodontitis and their saliva was collected. A highly specific point-of-care compatible dual color qPCR assay was developed and used to study the above-mentioned bacteria of interest in the collected saliva. Assay performance was compared to a commercially available microbial reference test. Eight out of ten taxa that were investigated during this study were strong discriminators between the periodontitis and healthy groups: C. rectus, T. forsythia, P. gingivalis, S. mutans, F. nucleatum, T. denticola, P. intermedia and oral Lactobacilli (p < 0.05). Significant differentiation between the periodontitis and caries group microbiome was only shown for S. mutans (p < 0.05). A clear distinction between oral health and disease was enabled by the analysis of quantitative qPCR data of target taxa levels in saliva.
- Published
- 2020
42. Effects of Additional Use of Bioactive Glasses or a Hydroxyapatite Toothpaste on Remineralization of Artificial Lesions in vitro
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Körner, Philipp, Schleich, Jana A, Wiedemeier, Daniel B, Attin, Thomas, Wegehaupt, Florian J, Körner, Philipp, Schleich, Jana A, Wiedemeier, Daniel B, Attin, Thomas, and Wegehaupt, Florian J
- Abstract
OBJECTIVES This in vitro study aimed to evaluate and compare the effect of two different bioactive glasses, a hydroxyapatite-containing, fluoride-free toothpaste (HTP) and a fluoride toothpaste (FTP) on the remineralization behavior of initial caries lesions. MATERIALS AND METHODS A total of 100 bovine enamel samples were randomly allocated to five groups of 20 samples each: NC = negative control group (artificial saliva); HTP = HTP group (Karex); FTP = FTP group (Elmex caries protection, 1,400 ppm); FTP + BGnano = FTP followed by Actimins bioactive glass; FTP + BGamorph = FTP followed by Schott bioactive glass. Radiographic documentation (advanced transversal microradiography; aTMR) was applied before and after all samples were exposed to a demineralizing gel for 10 days. Over a period of 28 days, samples were covered twice a day (every 12 h) with a toothpaste slurry of the respective test group or with artificial saliva in NC for 60 s and brushed with 15 brushing strokes. Samples in FTP + BGnano and FTP + BGamorph were additionally treated with the respective bioactive glass slurry for 30 s after brushing with the FTP. In the meantime, all samples were stored in artificial saliva. After 28 days, the structure of all samples was assessed again using aTMR and compared to the values measured after demineralization. The statistical evaluation of the integrated mineral loss was performed using Kruskal-Wallis test followed by a post hoc Conover test. RESULTS The FTP revealed the significantly highest increase of mineral content while the HTP showed the significantly lowest remineralization. Compared to artificial saliva, the use of the HTP or the combined application of FTP followed by bioactive glasses (FTP + BGnano and FTP + BGamorph) showed no significant remineralization. CONCLUSION Under remineralizing in vitro conditions, brushing with 1,400 ppm FTP induced significantly more remineralization compared to storage in artificial saliva. The additional administration
- Published
- 2020
43. Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring
- Author
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Paqué, Pune N., primary, Herz, Christopher, additional, Wiedemeier, Daniel B., additional, Mitsakakis, Konstantinos, additional, Attin, Thomas, additional, Bao, Kai, additional, Belibasakis, Georgios N., additional, Hays, John P., additional, Jenzer, Joël S., additional, Kaman, Wendy E., additional, Karpíšek, Michal, additional, Körner, Philipp, additional, Peham, Johannes R., additional, Schmidlin, Patrick R., additional, Thurnheer, Thomas, additional, Wegehaupt, Florian J., additional, and Bostanci, Nagihan, additional
- Published
- 2021
- Full Text
- View/download PDF
44. Toothpastes with Enzymes Support Gum Health and Reduce Plaque Formation
- Author
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Paqué, Pune N., primary, Schmidlin, Patrick R., additional, Wiedemeier, Daniel B., additional, Wegehaupt, Florian J., additional, Burrer, Phoebe D., additional, Körner, Philipp, additional, Deari, Shengjile, additional, Sciotti, Michel-Angelo, additional, and Attin, Thomas, additional
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- 2021
- Full Text
- View/download PDF
45. Einschätzung von Zahnärzten zu vermuteten Gründen für das Scheitern von Kompositfüllungen mittels Adhäsivtechnik
- Author
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Körner, Philipp, primary, Wegehaupt, Florian J., additional, and Attin, Thomas, additional
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- 2021
- Full Text
- View/download PDF
46. Integrating formal specifications into applications: the ProB Java API
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Körner, Philipp, primary, Bendisposto, Jens, additional, Dunkelau, Jannik, additional, Krings, Sebastian, additional, and Leuschel, Michael, additional
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- 2020
- Full Text
- View/download PDF
47. Microbial Analysis of Saliva to Identify Oral Diseases Using a Point-of-Care Compatible qPCR Assay
- Author
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Paqué, Pune N., primary, Herz, Christopher, additional, Jenzer, Joël S., additional, Wiedemeier, Daniel B., additional, Attin, Thomas, additional, Bostanci, Nagihan, additional, Belibasakis, Georgios N., additional, Bao, Kai, additional, Körner, Philipp, additional, Fritz, Tanja, additional, Prinz, Julia, additional, Schmidlin, Patrick R., additional, Thurnheer, Thomas, additional, Wegehaupt, Florian J., additional, Mitsakakis, Konstantinos, additional, and Peham, Johannes R., additional
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- 2020
- Full Text
- View/download PDF
48. REAL-Fog: A simple approach for calculating the fog in the atmosphere at ground level
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Körner, Philipp, primary, Kalaß, Dieter, additional, Kronenberg, Rico, additional, and Bernhofer, Christian, additional
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- 2020
- Full Text
- View/download PDF
49. FELIZ CUMPLE M.
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Eguiara, Juan Ignacio and Körner, Philipp
- Published
- 2022
50. “MI SUEÑO ES QUE EL URBAN REBEL SE CONDUZCA COMO UN KART”.
- Author
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KÖRNER., PHILIPP
- Published
- 2023
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