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2. Erratum: Acceleration of uranium beam to record power of 10.4 kW and observation of new isotopes at Facility for Rare Isotope Beams [Phys. Rev. Accel. beams 27, 060101 (2024)]

Author

P. N. Ostroumov, O. B. Tarasov, N. Bultman, F. Casagrande, Y. Choi, S. Cogan, M. Cortesi, K. Fukushima, A. Gonzalez, J. Guo, K. Haak, M. Hausmann, K. Hwang, M. Ikegami, D. Kaloyanov, T. Kanemura, S.-H. Kim, E. Kwan, M. Larmann, S. Lidia, G. Machicoane, T. Maruta, S. Miller, Y. Momozaki, D. Morris, A. Plastun, M. Portillo, X. Rao, I. Richardson, B. M. Sherrill, M. K. Smith, J. Song, M. Steiner, A. Stolz, S. Watters, J. Wei, T. Xu, T. Zhang, Q. Zhao, S. Zhao, D. S. Ahn, J. Hwang, T. Sumikama, and H. Suzuki

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2024
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3. THREE CASES OF TP53 BIALLELIC-MUTATED AML/MDS BRIDGED TO ALLO-HSCT BY AZA/VEN THERAPY

Author

T. Ueda, K. Fukushima, Y. Nannya, A. Hino, M. Hamada, Y. Mizutani, E. Mizuta, C. Hasegawa, Y. Yamaguchi, R. Kurashige, R. Nakai, S. Kusakabe, M. Ichii, J. Fujita, and N. Hosen

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: The prognosis of TP53 biallelic-mutated AML/MDS is severely poor. Azacitidine, venetoclax combination therapy (Aza/Ven) was shown to be effective and tolerable for AML patients who cannot receive standard chemotherapy and the efficacy even for adverse risk AML is expected. Methods: We report 3 cases of TP53 biallelic-mutated AML/MDS, successfully bridged to allo-HSCT by Aza/Ven. Results: Case 1 A 60-year-old male was diagnosed with MDS-MLD with complex karyotypes. TP53 p.V216G mutation (VAF 0.859) was detected by NGS. Because the disease progressed to MDS-EB1, one cycle of Aza/Ven was administered for disease control. No severe side effects happened during Aza/Ven. After allo-HSCT, CR was achieved and maintained for over 6 months. Case 2 A 57-year-old male was diagnosed as MDS-EB1 with complex karyotypes including -17. TP53 p.V216G mutation (VAF 0.733) and DNMT3A p.C497Y mutation were detected by NGS. After two cycles of Aza/Ven, myeloblasts in BM was decreased (9.4%→2.8%) without severe side effects. Although he received allo-HSCT, the disease relapsed. Case 3 A 62-year-old male was diagnosed with MDS-EB2. He has several complications including interstitial pneumonia. Although he received two cycles of Aza single therapy, the disease progressed. BM analysis revealed the complex karyotypes, including -17. TP53 p.R241 mutation (VAF 0.88) was detected by NGS. Thus, his treatment was switched to Aza/Ven. After two cycles of Aza/Ven, the disease did not progress, and no severe side effects were seen. He has just received allo-HSCT. Conclusions: Aza/Ven could be an effective treatment option as a bridging therapy toward allo-HSCT even in TP53 biallelic-mutated AML/MDS cases.

Published
2024
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4. First clinical evaluation of the QIAreachTM QuantiFERON-TB for tuberculosis infection and active pulmonary disease

Author

K. Fukushima, K. Akagi, A. Kondo, T. Kubo, N. Sakamoto, and H. Mukae

Subjects
QIAreachTM QuantiFERON-TB, QuantiFERON®-TB Gold Plus, Active tuberculosis, CD4 T-lymphocyte, CD8 T-lymphocyte, Diseases of the respiratory system, RC705-779
Abstract

Objective: 1) to compare the QIAreachTM QuantiFERON-TB (QIAreach QFT) vs. QuantiFERON®-TB Gold Plus assay (QFT-Plus) to detect tuberculosis (TB) infection; 2) to evaluate diagnostic sensitivity of QIAreach QFT using active TB as surrogate for TB infection; 3) to preliminarily evaluate QIAreach QFT in immunocompromised individuals. Methods: QIAreach QFT measures the level of interferon-γ (IFN-γ) in plasma specimens from blood stimulated by ESAT-6 and CFP-10 peptides in one blood collection tube (equivalent to the TB2 tube of the QFT-Plus). QIAreach QFT was applied to plasma samples from 41 patients with pulmonary TB and from 42 healthy or low-TB-risk individuals. Results: Sensitivity and specificity of QIAreach QFT vs. QFT-Plus were 100% (41/41) and 97.6% (41/42), respectively; overall concordance was 98.8% (82/83). All samples were measured within 20 min. The time to result of each sample was significantly correlated with IFN-γ level with a natural logarithmic scale (r = -0.913, p

Published
2022
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7. Beam commissioning in the first superconducting segment of the Facility for Rare Isotope Beams

Author

P. N. Ostroumov, T. Maruta, S. Cogan, K. Fukushima, S. H. Kim, S. Lidia, F. Marti, A. S. Plastun, J. Wei, T. Yoshimoto, T. Zhang, and Q. Zhao

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Linac segment 1 (LS1) of the FRIB driver linac is composed of 15 cryomodules, consisting of 104 superconducting (SC) resonators and 39 SC solenoids. Four ion beam species (Ne, Ar, Kr, and Xe) were successfully accelerated up to 20.3 MeV/u in LS1 and transported to the designated beam dumps located in folding segment 1 (FS1). 100% beam transmission was measured through all cryomodules and the warm section of LS1. High-power equivalent beams were delivered to the beam dump in two modes: pulsed and continuous wave (cw). In the pulsed mode, the peak intensity of the argon beam was 14.8 pμA at 3% duty factor, which constitutes 30% of the FRIB design intensity for this particular ion beam. A cw argon beam was accelerated, demonstrating that the FRIB linac in its current configuration is the highest-energy cw superconducting hadron linac in the world. This paper presents a detailed study of beam dynamics in LS1 prior to and after charge stripping with a carbon foil.

Published
2019
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9. Properties of poly(lactic acid) nanocomposites based on montmorillonite, sepiolite and zirconium phosphonate

Author

K. Fukushima, A. Fina, F. Geobaldo, A. Venturello, and G. Camino

Subjects
Nanocomposites, PLA, Montmorillonite Clay, Sepiolite, Zirconium phosphonate, Materials of engineering and construction. Mechanics of materials, TA401-492, Chemical technology, TP1-1185
Abstract

Poly(lactic acid) (PLA) based nanocomposites based on 5 wt.% of an organically modified montmorillonite (CLO), unmodified sepiolite (SEP) and organically modified zirconium phosphonate (ZrP) were obtained by melt blending. Wide angle X-ray scattering (WAXS) and scanning electron microscopy (SEM) analysis showed a different dispersion level depending on the type and functionalisation of nanoparticles. Differenctial scanning calorimetric (DSC) analysis showed that PLA was able to crystallize on heating, and that the addition of ZrP could promote extent of PLA crystallization, whereas the presence of CLO and SEP did not significantly affect the crystallization on heating and melting behaviour of PLA matrix. Dynamic Mechanical Thermoanalysis (DMTA) results showed that addition of all nanoparticles brought considerable improvements in E' of PLA, resulting in a remarkable increase of elastic properties for PLA nanocomposites. The melt viscosity and dynamic shear moduli (G',G") of PLA nanocomposites were also enhanced significantly by the presence of CLO and SEP, and attributed to the formation of a PLA/nanoparticle interconnected structure within the polymer matrix. The oxygen permeability of PLA did not significantly vary upon addition of SEP and ZrP nanoparticles. Only addition of CLO led to about 30% decrease compared to PLA permeability, due to the good clay dispersion and clay platelet-like morphology. The characteristic high transparency of PLA in the visible region was kept upon addition of the nanoparticles. Based on these achievements, a high potential of these PLA nanocomposites in sustainable packaging applications could be envisaged.

Published
2012
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10. Prodigiosin Production by Serratia marcescens UCP 1549 Using Renewable-Resources as a Low Cost Substrate

Author

Galba M. Campos Takaki, Helvia W. Casullo de Araújo, and K. Fukushima

Subjects
prodigiosin, Serratia marcescens, corn steep liquor, cassava liquid waste, mannitol, Organic chemistry, QD241-441
Abstract

A new strain of Serratia marcescens UCP1459 isolated from a semi-arid soil produced the natural red pigment prodigiosin, characterized by an uncommon pyrrolylpyrromethane skeleton. Prodigiosin is a promising drug due to its reported antifungal, immunosuppressive and anti-proliferative activities. The objective of this work was to indentify a suitable medium to simultaneously enhance S. marcescens growth and pigment production using renewable resources obtained from industrial wastes. S. marcescens produced the highest level of prodigiosin (49.5 g/L) at 48 h of cultivation using 6% “manipueira” (cassava wastewater) supplemented with mannitol (2%) at pH 7 and 28 °C. Carbohydrates in “manipueira” and mannitol play a role in the enhanced cell growth and prodigiosin production. The purified pigment extracted from the biomass was analyzed by mass spectrophotometry and showed the expected molecular weight of 324 Da corresponding to prodigiosin. In conclusion, we have successfully designed a new, economically feasible medium supporting enhanced S. marcescens growth and a high yield production of prodigiosin.

Published
2010
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11. Oral Candida flora from Brazilian human immunodeficiency virus-infected patients in the highly active antiretroviral therapy era

Author

NR Melo, H Taguchi, J Jorge, RJ Pedro, OP Almeida, K Fukushima, K Nishimura, and M Miyaji

Subjects
Candida, human immunodeficiency virus, antifungal drug, Brazil, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

One of the main opportunistic fungal infections amongst immunocompromised individuals is oral candidosis, which has been found in up to 90% of human immunodeficiency virus (HIV)-infected patients. This study employed yeasts isolated from the saliva and oral cavities of 114 HIV-infected patients living in Campinas, São Paulo. Of the isolates, 57.8% were identified as Candida albicans and 42.1% as non-C. albicans. The latter isolates were subsequently identified as C. krusei (7.5%), C. lusitaniae (5.2%), C. tropicalis (4.6%), C. parapsilosis (4.6%), C. glabrata (2.8%), C. kefyr (1.7%), C. guilliermondii (1.7%), C. intermedia (1.1%), C. norvegensis (0.5%), and Rhodotorula rubra (1.7%). Susceptibility of the isolates to amphotericin B, fluconazole, miconazole, and itraconazole was also determined by a microdilution method adopted by the National Committee for Clinical Laboratory Standards. The isolates demonstrated various susceptibilities to the antifungal agents. In particular 29 C. albicans and 13 non-C. albicans isolates showed low susceptibility to FLCZ (> 64 µg/ml). This study revealed huge diversity of Candida species, in particular the increasing emergence of non-C. albicans associated with the oral flora of HIV-infected patients.

Published
2004
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12. Coherent resonance stop bands in alternating gradient beam transport

Author

K. Ito, H. Okamoto, Y. Tokashiki, and K. Fukushima

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

An extensive experimental study is performed to confirm fundamental resonance bands of an intense hadron beam propagating through an alternating gradient linear transport channel. The present work focuses on the most common lattice geometry called “FODO” or “doublet” that consists of two quadrupoles of opposite polarities. The tabletop ion-trap system “S-POD” (Simulator of Particle Orbit Dynamics) developed at Hiroshima University is employed to clarify the parameter-dependence of coherent beam instability. S-POD can provide a non-neutral plasma physically equivalent to a charged-particle beam in a periodic focusing potential. In contrast with conventional experimental approaches relying on large-scale machines, it is straightforward in S-POD to control the doublet geometry characterized by the quadrupole filling factor and drift-space ratio. We verify that the resonance feature does not essentially change depending on these geometric factors. A few clear stop bands of low-order resonances always appear in the same pattern as previously found with the sinusoidal focusing model. All stop bands become widened and shift to the higher-tune side as the beam density is increased. In the space-charge-dominated regime, the most dangerous stop band is located at the bare betatron phase advance slightly above 90 degrees. Experimental data from S-POD suggest that this severe resonance is driven mainly by the linear self-field potential rather than by nonlinear external imperfections and, therefore, unavoidable at high beam density. The instability of the third-order coherent mode generates relatively weak but noticeable stop bands near the phase advances of 60 and 120 degrees. The latter sextupole stop band is considerably enhanced by lattice imperfections. In a strongly asymmetric focusing channel, extra attention may have to be paid to some coupling resonance lines induced by the Coulomb potential. Our interpretations of experimental data are supported by theoretical predictions and systematic multiparticle simulations.

Published
2017
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14. First clinical evaluation of the QIAreach

Author

K, Fukushima, K, Akagi, A, Kondo, T, Kubo, N, Sakamoto, and H, Mukae

Subjects
Aged, 80 and over, Male, Interferon-gamma, Latent Tuberculosis, Tuberculin Test, Humans, Tuberculosis, Female, Mycobacterium tuberculosis, Sensitivity and Specificity, Tuberculosis, Pulmonary, Interferon-gamma Release Tests, Aged
Abstract

1) to compare the QIAreachQIAreach QFT measures the level of interferon-γ (IFN-γ) in plasma specimens from blood stimulated by ESAT-6 and CFP-10 peptides in one blood collection tube (equivalent to the TB2 tube of the QFT-Plus). QIAreach QFT was applied to plasma samples from 41 patients with pulmonary TB and from 42 healthy or low-TB-risk individuals.Sensitivity and specificity of QIAreach QFT vs. QFT-Plus were 100% (41/41) and 97.6% (41/42), respectively; overall concordance was 98.8% (82/83). All samples were measured within 20 min. The time to result of each sample was significantly correlated with IFN-γ level with a natural logarithmic scale (r = -0.913, p 0.001). Seven cases in the active TB group were immunocompromised (CD4200/μL) and tested positive by QIAreach QFT.QIAreach QFT provides an objective readout with a minimum blood sample volume (1 mL/subject), potentially being a useful point-of-care screening test for TB infection in high-TB-burden, low-resource countries and for immunocompromised patients.

Published
2021

15. Isolation of fungi from nature in the region of Botucatu, state of São Paulo, Brazil, an endemic area of paracoccidioidomycosis

Author

MR Montenegro, M Miyaji, M Franco, K Nishimura, KI Coelho, Y Horie, RP Mendes, A Sano, K Fukushima, and D Fecchio

Subjects
ecology, nature, pathogenic fungi, Paracoccidioides brasiliensis, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

In an attempt to isolate Paracoccidioides brasiliensis from nature 887 samples of soil from Botucatu, SP, Brazil, were collected cultured in brain heart infusion agar supplemented with dextrose, in potato dextrose agar and in yeast extract starch dextrose agar, all with antibiotics, at 25º and 37ºC. Five thermo-dependent dimorphic fungi morphologically resembling P. brasiliensis were isolated; two from armadillo holes; further studies of the biology, antigenicity and genetic features of the five dimorphic fungi are necessary to clarify their taxonomy and their possible relation to P. brasiliensis. In addition, 98 dematiaceous fungi and 581 different species of Aspergillus spp. were also isolated. Our findings emphasize that armadillos and their environment are associated with thermo-dimorphic fungi and confirm the ubiquity of pathogenic dematiaceous fungi and Aspergillus spp.

Published
1996
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17. Simultaneous confinement of low-energy electrons and positrons in a compact magnetic mirror trap

Author

H Higaki, C Kaga, K Fukushima, H Okamoto, Y Nagata, Y Kanai, and Y Yamazaki

Subjects
electron–positron plasma, non-neutral plasma, magnetic mirror, Science, Physics, QC1-999
Abstract

More than 10 ^7 electrons and 10 ^5 positrons with energy less than a few eV were confined simultaneously for the first time in a compact magnetic mirror trap with plugging potentials. The exponential decay time constant of the confined positrons exceeded 70 ms at the beginning of the simultaneous confinement. Particle simulations in the early stages of the mixing process were also conducted. The results obtained in the experiments and simulations suggested that an improved setup would make it possible to investigate the unexplored field of low-energy electron–positron plasmas experimentally.

Published
2017
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18. Double stop-band structure near half-integer tunes in high-intensity rings

Author

K. Moriya, M. Ota, K. Fukushima, M. Yamaguchi, K. Ito, and H. Okamoto

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

This paper addresses a detailed experimental study of collective instability bands generated near every half-integer tune per lattice period by coherent dipole and quadrupole resonances. Both instabilities appear side by side or overlap each other but are mostly separable because the dipole resonance often creates a narrower stop band accompanied by more severe particle losses. The separation of these low-order resonance bands becomes greater as the beam intensity increases. In principle, the double stop-band structure can be formed even without machine imperfections when the beam’s initial phase-space profile is deviated from the ideal stationary distribution. The tabletop ion-trap system called “S-POD” is employed to experimentally demonstrate the parameter dependence of the double stop-band structure. Numerical simulations are also performed for comparison with experimental observations.

Published
2016
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19. Regulation of bile acid synthesis in the rat: relationship between hepatic cholesterol 7 alpha-hydroxylase activity and portal bile acids.

Author

K Fukushima, H Ichimiya, H Higashijima, H Yamashita, S Kuroki, K Chijiiwa, and M Tanaka

Subjects
Biochemistry, QD415-436
Abstract

Bile acid biosynthesis has been believed to be regulated by negative feedback control; however, recent experiments have cast considerable doubts on the concept. The aim of the study was to examine the consensus of the negative feedback regulation of bile acids by clarifying the correlation between the portal bile acids and the rate-limiting enzyme of bile acid biosynthesis, hepatic microsomal cholesterol 7 alpha-hydroxylase. We measured the enzyme activity and the portal bile acids in male Wistar rats that were orally administered three different bile acids or cholestyramine for 2 weeks. The serum level of 7 alpha-hydroxycholesterol was also determined to verify whether it would be a parameter of bile acid synthesis rate in the rat. The activity of cholesterol 7 alpha-hydroxylase increased about threefold in rats treated with cholestyramine when compared with controls. On the other hand, in rats fed ursodeoxycholic, chenodeoxycholic, and deoxycholic acids, the enzyme activities decreased to 40%, 26%, and 28%, respectively. Treatment with cholestyramine had no significant effect on the portal bile acid concentration. Administration of ursodeoxycholic and chenodeoxycholic acids resulted in a significant increase in the concentration of portal bile acids, whereas deoxycholic acid feeding did not significantly affect it. In the control group, conjugated cholic acid constituted a major part of the portal bile acids while the administered bile acid and its metabolites became predominant in each bile acid feeding group. Treatment with ursodeoxycholic acid made the portal bile acids more hydrophilic, but, by contrast, administration of chenodeoxycholic, deoxycholic acids, and cholestyramine made the portal bile acids more hydrophobic.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1995
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20. The correlations between anti-factor Xa activity values and PT/APTT at peak and trough times in patients with venous thromboembolism using high dose of apixaban

Author

K Fukushima, Y Hori, H Takahashi, R Ono, and T Yamazaki

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Medicine, Anti-Factor Xa Activity, Apixaban, In patient, Cardiology and Cardiovascular Medicine, business, Trough (economics), Venous thromboembolism, Gastroenterology, medicine.drug
Abstract

Background The high dose (20mg/day) of apixaban is used for the initial treatment of venous thromboembolism for the first week. Although patients taking direct oral anticoagulants do not require routine coagulation monitoring, the correlations between anti-factor Xa activity (AXA) and routine coagulation markers such as prothrombin time (PT) and activated partial thromboplastin time (APTT) at peak and trough times especially when using high dose of apixaban have not been reported so far. Purpose The purpose is to assess the correlations between AXA values and PT/APTT at peak and trough times in patients with venous thromboembolism using high dose of Apixaban. Methods Twenty-six patients (10 male; 71±15 years) with proximal venous thromboembolism or pulmonary embolism using high dose (20mg/day) of apixaban were enrolled. We measured AXA, using chromogenic assay with the HemosIL Liquid Heparin kit, PT and APTT at peak and trough times. The peak time was defined as 3 hours after the intake of apixaban, and the trough time was defined as that immediately before the intake of apixaban. Results A significant and strong positive correlation was observed between AXA and PT at both peak and trough times (R=0.795, p Conclusion Our findings reveal the relationship between AXA and PT at peak and trough times has a significant strong correlation. These results suggest measuring of PT may be alternative and effective way of monitoring of AXA values when using high dose of apixaban. Figure 1 Funding Acknowledgement Type of funding source: None

Published
2020
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21. The distribution of anti-factor Xa activity value, PT and APTT at peak and trough times in patients with direct anti-factor Xa inhibitors

Author

H Takahashi, K Fukushima, Y Hori, T Yamazaki, and R Ono

Subjects
Prothrombin time, Rivaroxaban, medicine.diagnostic_test, business.industry, Heparin, Pharmacology, Trough (economics), chemistry.chemical_compound, chemistry, Edoxaban, Medicine, Apixaban, Trough Concentration, Anti factor xa, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Background Although patients taking direct oral anticoagulants (DOACs) do not require routine coagulation monitoring, the distribution of anti-factor Xa activity (AXA) values, prothrombin time (PT), PT-international normalized ratio (INR) and activated partial thromboplastin time (APTT) in patients on apixaban, edoxaban and rivaroxaban therapy is still not clear. Purpose The aim is to set the standard values of AXA values, PT, PT-INR and APTT in patients using DOACs. Methods We measured AXA, using chromogenic assay with the HemosIL Liquid Heparin kit, PT, PT-INR and APTT at trough and peak times in 224 patients with non-valvular atrial fibrillation and venous thromboembolism, of whom 90 received apixaban, 100 received edoxaban and 34 received rivaroxaban. The peak time was defined as 3 hours after the intake of apixaban or rivaroxaban, and 2 hours after the intake of edoxaban. The trough time was defined as that immediately before the intake. The AXA values, PT, PT-INR and APTT were measured at least 72 hours after the start of treatment. The dosage of DOACs is defined according to the prescribing information in Japan. Results (The order of results below is apixaban, edoxaban and rivaroxaban, respectively.) The average AXA values were 2.29, 0.23 and 0.39 (IU/mL) at trough time, and 3.04, 1.01 and 1.70 (IU/mL) at peak time. The average PT values were 17.9, 12.9 and 13.1 (s) at trough time, and 19.7, 15.5 and 17.5 (s) at peak time. The average PT-INR values were 1.49, 1.07 and 1.08 at trough time, and 1.65, 1.29 and 1.45 at peak time. The average APPT values were 34.5, 31.3 and 32.0 (s) at trough time, and 39.5, 35.9 and 39.8 (s) at peak time. Conclusion Our findings reveal the standard values of AXA, PT, PT-INR and APTT in patients using apixaban, edoxaban and rivaroxaban in each dosage. The DOACs should be changed if the measured value is out of those standard values in 90% confidence interval. Funding Acknowledgement Type of funding source: None

Published
2020
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22. Multicenter study of QuantiFERON®-TB Gold Plus in patients with active tuberculosis

Author

David M. Koelle, Kevin L. Winthrop, A. H. Chang, M. Narita, Sarah A.R. Siegel, Andrea Kovacs, K Fukushima, P Anthony, K A Meekin, Brenda E. Jones, A Kamada, P. R. Kerndt, David J. Horne, and S Bhat

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, business.industry, 030106 microbiology, bacterial infections and mycoses, medicine.disease, Active tuberculosis, QuantiFERON, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Multicenter study, Tuberculosis diagnosis, Internal medicine, Epidemiology, medicine, In patient, 030212 general & internal medicine, Interferon-gamma Release Tests, business
Abstract

Setting QuantiFERON®-TB Gold Plus (QFT-Plus), recently approved for use in the United States, is a new-generation QuantiFERON assay that differs from its predecessors in that it uses an additional antigen tube containing peptides to elicit both CD8+ and CD4+ T-lymphocyte responses. Objective To assess the sensitivity of QFT-Plus compared with QuantiFERON®-TB Gold In-Tube (QFT-GIT) in participants with active TB. Design Adult patients with active TB at three US and two Japanese sites were eligible for this study if they had culture-confirmed TB and were either untreated or had received 14 days of anti-tuberculosis treatment. Results We enrolled 164 participants, nine of whom had indeterminate results. Excluding indeterminate values, there were 150 QFT-GIT-positive results among 159 tests and 146 QFT-Plus-positive results among 157 tests, with sensitivities of respectively 94.3% (95%CI 89.5-97.4) and 93.02% (95%CI 87.8-96.5%). The estimated sensitivities for the two tests were not significantly different (P = 0.16). Overall test agreement was 98.7%, with a κ statistic of 0.89 (95%CI 0.75-1.00). Conclusion In this multisite study, we found that QFT-Plus had similar sensitivity to QFT-GIT in adult patients with active TB.

Published
2018
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23. Experimental study of integer resonance crossing in a nonscaling fixed field alternating gradient accelerator with a Paul ion trap

Author

K. Moriya, K. Fukushima, K. Ito, T. Okano, H. Okamoto, S. L. Sheehy, D. J. Kelliher, S. Machida, and C. R. Prior

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

We present an experimental study aimed at exploring integer resonance crossing with a focus on nonscaling fixed field alternating gradient accelerators. The method uses the Simulator of Particle Orbit Dynamics system at Hiroshima University based on a compact ion trap known as a Paul trap. In a setup that mimics the Electron Model for Many Applications nonscaling fixed field alternating gradient accelerator, we have verified the theoretical prediction of the coherent excitation of dipole motion over a wide range of errors and crossing speeds. In addition, the cancellation of amplitude growth dependent on the relative betatron oscillation phase between two consecutive resonances is observed and studied. We also explore nonlinear effects and, in particular, the effects of amplitude-dependent tune shifts and find that these nonlinear effects are a key factor in understanding our experimental results.

Published
2015
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24. P3354Papillary muscle ischemia and global myocardial flow reserve: assessment by high-resolution cine imaging of 13N ammonia PET

Author

Y Matsuo, R Nakao, K. Fukushima, M. Momose, A Sakai, E Watanabe, N Kasuga, M Nagao, and Nobuhisa Hagiwara

Subjects
Cine imaging, (13N)Ammonia, business.industry, Medicine, High resolution, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Muscle ischemia
Abstract

Purpose Papillary muscle ischemia (PMI) is caused by micro-vessels' occlusion in the broad endocardium because papillary muscle perfusion is supply from micro-vessels of peripheral coronary arteries and is easy to fail by the increase in peripheral vascular resistance. However, the clinical significant is not understood because PMI could not be detected by existing perfusion imaging such as SPECT and MRI. We propose the detection method of PMI using 13N-ammonia PET (NH3-PET), and investigate the association with the global myocardial flow reserve (Global-MFR) reflecting coronary microvascular dysfunction. Methods Data of adenosine-stress NH3-PET for consecutive 260 patients with coronary artery disease (CAD) or suspected CAD was retrospectively analyzed. Using high-resolution cine imaging derived from NH3-PET, PMI was defined as the absence of the PM accumulation at stress conditions. Myocardial flow was generated from the time activity curve of left ventricle input and myocardial uptake using 3-compartment model and the first 2 minutes' dataset of list mode images. Global-MFR was calculated by stress to rest flow ratio. Summed stress score (SSS) was used as an estimate of the extent of myocardial ischemia. 150 out of 260 patients (58%) with SSS ≥4 or with the past history of coronary artery diseases were classified as ischemic group, and 110 patients (42%) with SSS Results PMI was seen in 68 of 260 patients (26.6%). The frequency of PMI was higher in the ischemic group than the non-ischemic group (37.8% vs. 10.1%, p Typical case of PMI Conclusion High-resolution cine imaging derived from NH3-PET makes it possible to detect PMI in about a quarter of patients with CAD or suspected CAD. PMI associates with reduced Global-MFR regardless of the presence of myocardial ischemia, suggesting that PMI is an important sign of early ischemia confined to the papillary muscle or the broad microvascular injury.

Published
2019
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25. Severity assessment in pigs after partial liver resection: evaluation of a score sheet

Author

Kerstin Hagemeister, Lisa Ernst, K Fukushima, Rene Tolba, Pramod Kadaba Srinivasan, and Hirokazu Tanaka

Subjects
medicine.medical_specialty, General Veterinary, business.industry, Sus scrofa, Resection, Surgery, Severity assessment, Models, Animal, medicine, Animals, Hepatectomy, Animal Science and Zoology, Female, business, Pain Measurement
Abstract

Severity assessment in biomedical research is required by the European authorities. Therefore, a variety of score sheets are available. The first score sheets were designed and introduced by Morton and Griffith (M&G) in 1985, to assess pain and distress in animals. Score sheets are an important part of the 3R principles to evaluate the degree of severity in different studies. Here, we used a modified score sheet from M&G for severity assessment of 12 Aachen minipigs after partial liver resection for safety testing of a novel synthetic sealant (VIVO-107). The control group was treated with the clinical standard fibrin. Estimation of recovery status of both groups was performed from the day of surgery to postoperative day 7 using a score sheet. Included parameters were blood loss during the surgical procedure, general state, spontaneous behaviour and clinical results. Values from 0 to 20 were graded for each category and resulted in the degree of strain (DS) from DS0 to DS4. An increasing DS indicated higher severity. Suitability of the implemented score sheet was evaluated. Higher score points were documented almost exclusively as an outcome of the clinical results, influenced mainly by increased temperature in the fibrin treated control group, whereas, spontaneous behaviour had only slight influence and general state had no influence. The average score seven days after surgery was

Published
2019

26. Beam commissioning in the first superconducting segment of the Facility for Rare Isotope Beams

Author

Alexander Plastun, Felix Marti, Sang-Hoon Kim, Peter Ostroumov, T. Zhang, Steven Lidia, Scott Cogan, K. Fukushima, J. Wei, Takashi Yoshimoto, Qiang Zhao, and T. Maruta

Subjects
Nuclear physics, Superconductivity, Physics, Nuclear and High Energy Physics, Physics and Astronomy (miscellaneous), Isotope, Beam commissioning, Physics::Accelerator Physics, lcsh:QC770-798, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Surfaces and Interfaces
Abstract

Linac segment 1 (LS1) of the FRIB driver linac is composed of 15 cryomodules, consisting of 104 superconducting (SC) resonators and 39 SC solenoids. Four ion beam species (Ne, Ar, Kr, and Xe) were successfully accelerated up to 20.3 MeV/u in LS1 and transported to the designated beam dumps located in folding segment 1 (FS1). 100% beam transmission was measured through all cryomodules and the warm section of LS1. High-power equivalent beams were delivered to the beam dump in two modes: pulsed and continuous wave (cw). In the pulsed mode, the peak intensity of the argon beam was 14.8 pμA at 3% duty factor, which constitutes 30% of the FRIB design intensity for this particular ion beam. A cw argon beam was accelerated, demonstrating that the FRIB linac in its current configuration is the highest-energy cw superconducting hadron linac in the world. This paper presents a detailed study of beam dynamics in LS1 prior to and after charge stripping with a carbon foil.

Published
2019

27. Heavy ion beam acceleration in the first three cryomodules at the Facility for Rare Isotope Beams at Michigan State University

Author

Alexander Plastun, J. Wong, T. Maruta, Qiang Zhao, J. Wei, Takashi Yoshimoto, Scott Cogan, Steven Lidia, Peter Ostroumov, and K. Fukushima

Subjects
Physics, Nuclear and High Energy Physics, Argon, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, Krypton, chemistry.chemical_element, Surfaces and Interfaces, 01 natural sciences, Electron cyclotron resonance, Ion source, Linear particle accelerator, Nuclear physics, Acceleration, chemistry, Radio-frequency quadrupole, 0103 physical sciences, 010306 general physics, Beam (structure)
Abstract

The Facility for Rare Isotope Beams (FRIB) being constructed at Michigan State University [J. Wei et al., The FRIB superconducting linac---status and plans, LINAC'16, Lansing, MI, p. 1, http://accelconf.web.cern.ch/AccelConf/linac2016/papers/mo1a01.pdf] is based on a cw superconducting linear accelerator which is designed to deliver unprecedented 400 kW heavy ion beam power to the fragmentation target. The installation of the accelerator equipment is approaching completion and multistage beam commissioning activities started in the summer of 2017 with expected completion in 2021. A room-temperature test electron cyclotron resonance ion source, ARTEMIS, provided argon and krypton beams for the commissioning of the low energy beam transport, a radio frequency quadrupole (RFQ), the medium energy beam transport (MEBT) and the first three accelerating cryomodules. The commissioning of the first linac segment (LS1), composed of 15 cryomodules, is planned in the spring of 2019. This paper describes the first results of experimental beam dynamics studies in the LEBT, RFQ, MEBT and the first three cryomodules with comparison to the numerical simulations.

Published
2019
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28. Recommendation for severity assessment following liver resection and liver transplantation in rats: Part I

Author

Rene Tolba, A Rix, K Fukushima, Hirokazu Tanaka, K. Pawlowsky, S Kanzler, Zoltan Czigany, and Babette Kögel

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Orthotopic liver transplantation, medicine.medical_treatment, macromolecular substances, Liver transplantation, Animal Welfare, Gastroenterology, Resection, 03 medical and health sciences, Severity assessment, Internal medicine, medicine, Lewis rats, Animals, Hepatectomy, Rats, Wistar, Pain Measurement, General Veterinary, business.industry, Liver Transplantation, Rats, Transplantation, Distress, 030104 developmental biology, Rats, Inbred Lew, Research Design, Animal Science and Zoology, business
Abstract

Score sheets were first introduced 30 years ago to assess pain, distress and suffering in animals. To date, however, there is still no general agreement on their use in research practice, and only a few publications can be found on this topic. In the present work, we demonstrate the use of a special score sheet for severity assessment in the first three postoperative days in two showcased studies performed on Wistar and Lewis rats undergoing liver resection or orthotopic liver transplantation, respectively. Scoring of different criteria and the total score were evaluated within each intervention. Additionally, both procedures were compared regarding their degree of severity. Suitability of these score sheets was evaluated for assessing severity of the procedures and these showed a minor severity within each investigated study. A comparison of both studies showed slightly higher scores involving liver transplantation. In contradiction to the common classification of these procedures as a moderate severity grade the score sheets applied here indicates a minor severity grade within each investigated study. Also, limitations and possible improvements in the design of our score sheets for defined interventions are reconsidered.

Published
2016
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29. Severity assessment in rabbits after partial hepatectomy: Part II

Author

Natascha Drude, Rene Tolba, K Fukushima, Hirokazu Tanaka, K. Pawlowsky, and Babette Kögel

Subjects
medicine.medical_specialty, General Veterinary, 040301 veterinary sciences, business.industry, 05 social sciences, 04 agricultural and veterinary sciences, Partial hepatectomy, Animal Welfare, Surgery, 0403 veterinary science, Severity assessment, Distress, Research Design, medicine, Animals, Hepatectomy, Female, 0501 psychology and cognitive sciences, Animal Science and Zoology, Rabbits, 050102 behavioral science & comparative psychology, business, Pain Measurement
Abstract

Although the recognition of pain, distress and discomfort has already been described in 1985 by Morton and Griffiths there is still very little known about the establishment of score sheets especially, regarding post-surgical pain and severity assessment for laboratory animals such as rabbits. In this paper we describe the estimation of severity and recovery status of 36 female New Zealand White rabbits (NZW) in a standardized liver resection model using two different adhesive treatments and one control group. Welfare was assessed at 3–4 consecutive days after surgery using a scoring system which included the following criteria: body weight, general state, clinical results, spontaneous behavior and clinical examination. Values could range from 0 to 20 where increasing values indicated increasing severity with a predefined humane endpoint for a score ≥20 points. Documented score points were almost exclusively a result of body weight loss, whereas clinical signs and general health status had no influence on the overall sum of points scored. Behavioral variation was solely observed postoperatively, within the first 24 h, with an average score ≤1. In contrast to the classification of a laparotomy as a moderate procedure in the EU Directive 2010/63 (annex VIII) the assessment herein presented showed a mild burden in all groups according to the scoring system used. The partial hepatectomy itself, as well as the adhesive treatment using either synthetic glue VIVO-107 or fibrin glue, were well tolerated.

Published
2016
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31. Experimental study of resonance crossing with a Paul trap

Author

H. Takeuchi, K. Fukushima, K. Ito, K. Moriya, H. Okamoto, and H. Sugimoto

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The effect of resonance crossing on beam stability is studied systematically by employing a novel tabletop experimental tool and a multiparticle simulation code. A large number of ions are confined in a compact linear Paul trap to reproduce the collective beam behavior. We can prove that the ion plasma in the trap is physically equivalent to a charged-particle beam propagating through a strong focusing channel. The plasma confinement force is quickly ramped such that the trap operating point traverses linear and nonlinear resonance stop bands. Assuming a nonscaling fixed field alternating gradient accelerator composed of many identical FODO cells, we measure how much ion losses occur under diverse conditions. It is experimentally and numerically demonstrated that too slow resonance crossing leads to significant ion losses as expected. Particular attention must be paid to the linear coherent resonance excited at a quarter-integer tune. When the beam intensity is high, this type of linear stop band can seriously affect the beam quality even for rather fast resonance crossing. A scaling law is given of the emittance growth caused by the quarter-integer resonance crossing.

Published
2012
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32. Multicenter study of QuantiFERON

Author

D J, Horne, B E, Jones, A, Kamada, K, Fukushima, K L, Winthrop, S A R, Siegel, A, Kovacs, P, Anthony, K A, Meekin, S, Bhat, P, Kerndt, A, Chang, D M, Koelle, and M, Narita

Subjects
Aged, 80 and over, CD4-Positive T-Lymphocytes, Male, Japan, Humans, Tuberculosis, Female, CD8-Positive T-Lymphocytes, Middle Aged, Sensitivity and Specificity, Interferon-gamma Release Tests, United States, Aged
Abstract

QuantiFERON®-TB Gold Plus (QFT-Plus), recently approved for use in the United States, is a new-generation QuantiFERON assay that differs from its predecessors in that it uses an additional antigen tube containing peptides to elicit both CD8+ and CD4+ T-lymphocyte responses.To assess the sensitivity of QFT-Plus compared with QuantiFERON®-TB Gold In-Tube (QFT-GIT) in participants with active TB.Adult patients with active TB at three US and two Japanese sites were eligible for this study if they had culture-confirmed TB and were either untreated or had received 14 days of anti-tuberculosis treatment.We enrolled 164 participants, nine of whom had indeterminate results. Excluding indeterminate values, there were 150 QFT-GIT-positive results among 159 tests and 146 QFT-Plus-positive results among 157 tests, with sensitivities of respectively 94.3% (95%CI 89.5-97.4) and 93.02% (95%CI 87.8-96.5%). The estimated sensitivities for the two tests were not significantly different (P = 0.16). Overall test agreement was 98.7%, with a κ statistic of 0.89 (95%CI 0.75-1.00).In this multisite study, we found that QFT-Plus had similar sensitivity to QFT-GIT in adult patients with active TB.

Published
2018

33. Experimental study on dipole motion of an ion plasma confined in a linear Paul trap

Author

K. Fukushima, Hiromi Okamoto, T. Okano, K. Moriya, Hiroyuki Higaki, and Kiyokazu Ito

Subjects
Nuclear and High Energy Physics, Chemistry, Plasma, Condensed Matter Physics, Penning trap, Atomic and Molecular Physics, and Optics, Ion, Trap (computing), Dipole, Physics::Plasma Physics, Magnetic trap, Physics::Atomic Physics, Ion trap, Physical and Theoretical Chemistry, Atomic physics, Quadrupole ion trap
Abstract

The compact non-neutral plasma trap systems named “S-POD” have been developed at Hiroshima University as an experimental simulator of beam dynamics. S-POD is based either on a linear Paul trap or on a Penning trap and can approximately reproduce the collective motion of a relativistic charged-particle beam observed in the center-of-mass frame.We here employ the Paul trap system to investigate the behavior of an ion plasma near a dipole resonance. A simple method is proposed to calibrate the data of secular frequency measurements by using the dipole instability condition. We also show that the transverse density profile of an ion plasma in the trap can be estimated from the time evolution of ion losses caused by the resonance.

Published
2015
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35. P4341Detection of undiagnosed cardiac sarcoidosis by FDG-PET and SPECT among patients with Atrioventricular Block routinely followed in a pacemaker outpatient clinic

Author

Tsuyoshi Shiga, Nobuhisa Hagiwara, M. Momose, K. Fukushima, and N. Serizawa

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Cardiac sarcoidosis, Single-photon emission computed tomography, medicine.disease, law.invention, Fluorodeoxyglucose positron emission tomography, law, Internal medicine, medicine, Cardiology, Artificial cardiac pacemaker, Outpatient clinic, Radiology, Cardiology and Cardiovascular Medicine, business, Atrioventricular block
Published
2017
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36. P3694Multicenter research of bleeding risk between low dose prasugrel and standard dose clopidogrel in patients with coronary artery disease undergoing percutaneous coronary intervention

Author

K. Fukushima, Nobuaki Shikama, Yoshio Kobayashi, M. Nameki, Hideki Kitahara, Takashi Nakayama, T. Shiba, S. Tokimasa, Yoshihide Fujimoto, and Toshiharu Himi

Subjects
medicine.medical_specialty, Prasugrel, business.industry, medicine.medical_treatment, Low dose, Percutaneous coronary intervention, Clopidogrel, medicine.disease, Coronary artery disease, Internal medicine, medicine, Cardiology, In patient, Cardiology and Cardiovascular Medicine, business, medicine.drug
Published
2017
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37. 4783The incidence and clinical significance of 18F-fluorodeoxyglucose re-uptake on cardiac positron emission tomography in patient with cardiac sarcoidosis after receiving corticosteroid therapy

Author

Tsuyoshi Shiga, N. Serizawa, Nobuhisa Hagiwara, K. Fukushima, M. Momose, and A. Nomura

Subjects
Fluorodeoxyglucose, medicine.medical_specialty, business.industry, Incidence (epidemiology), Cardiac sarcoidosis, Corticosteroid therapy, medicine, Clinical significance, In patient, Radiology, Cardiology and Cardiovascular Medicine, Cardiac positron emission tomography, business, medicine.drug
Published
2017
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38. Coherent resonance stop bands in alternating gradient beam transport

Author

Y. Tokashiki, K. Fukushima, Kiyokazu Ito, and Hiromi Okamoto

Subjects
Physics, Nuclear and High Energy Physics, Physics and Astronomy (miscellaneous), Condensed matter physics, 010308 nuclear & particles physics, Filling factor, Resonance, Surfaces and Interfaces, Stopband, Betatron, 01 natural sciences, Instability, Computational physics, Nonlinear system, 0103 physical sciences, Quadrupole, lcsh:QC770-798, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Electric potential, 010306 general physics
Abstract

An extensive experimental study is performed to confirm fundamental resonance bands of an intense hadron beam propagating through an alternating gradient linear transport channel. The present work focuses on the most common lattice geometry called ``FODO'' or ``doublet'' that consists of two quadrupoles of opposite polarities. The tabletop ion-trap system ``S-POD'' (Simulator of Particle Orbit Dynamics) developed at Hiroshima University is employed to clarify the parameter-dependence of coherent beam instability. S-POD can provide a non-neutral plasma physically equivalent to a charged-particle beam in a periodic focusing potential. In contrast with conventional experimental approaches relying on large-scale machines, it is straightforward in S-POD to control the doublet geometry characterized by the quadrupole filling factor and drift-space ratio. We verify that the resonance feature does not essentially change depending on these geometric factors. A few clear stop bands of low-order resonances always appear in the same pattern as previously found with the sinusoidal focusing model. All stop bands become widened and shift to the higher-tune side as the beam density is increased. In the space-charge-dominated regime, the most dangerous stop band is located at the bare betatron phase advance slightly above 90 degrees. Experimental data from S-POD suggest that this severe resonance is driven mainly by the linear self-field potential rather than by nonlinear external imperfections and, therefore, unavoidable at high beam density. The instability of the third-order coherent mode generates relatively weak but noticeable stop bands near the phase advances of 60 and 120 degrees. The latter sextupole stop band is considerably enhanced by lattice imperfections. In a strongly asymmetric focusing channel, extra attention may have to be paid to some coupling resonance lines induced by the Coulomb potential. Our interpretations of experimental data are supported by theoretical predictions and systematic multiparticle simulations.

Published
2017

39. J-PARC-HI Collaboration

Author

H. Fujii, S. Kato, Kenta Shigaki, I.K. Yoo, Ken Oyama, Masahiro Okamura, Chiho Nonaka, J. Kamiya, Masakiyo Kitazawa, Masayasu Harada, Prakhar Garg, Shoichi Hasegawa, K. Itakura, Tamás Csörgő, D. K. Mishra, L. Nadjdjerdj, Masanori Ogino, K. Sato, M. Naruki, K. Morita, K. Tanida, A. Okabe, E.J. Kim, M. Yoshimoto, Y. Watanabe, Tetsuo Hatsuda, H. Sako, F. Tamura, S. Sawada, T. Maruyama, K. Imai, Taku Gunji, Tatsuya Chujo, Yudai Ichikawa, Jovan Milosevic, X. Luo, M. Dordevic, Y. Takeuchi, Byung-Sik Hong, Predrag Cirkovic, T. Hachiya, Masayuki Asakawa, T. Ichisawa, Kyoichiro Ozawa, S. Esumi, M. Stojanovic, K. Fukushima, Motoi Inaba, Tetsufumi Hirano, H. Harada, Yasushi Nara, S. Yokkaichi, Susumu Sato, A. Kovalenko, M. Kinsho, J. Tamura, Y. Liu, Masashi Kaneta, M. Yamamoto, Aya Sakaguchi, S. Ashikaga, H. Tamura, T. Nonaka, Hideaki Hotchi, Hitoshi Sugimura, Y. Shobuda, N. Tani, A. Nakamura, Damir Devetak, S. Nagamiya, M. Chiu, Akira Ohnishi, S. Shimansky, B.C. Kim, S. Sakai, Yukinao Akamatsu, T. Nakamura, Katsuhisa Nishio, H. Kato, J.K. Ahn, Makoto Oka, K.H. Tanaka, Koichi Murase, T. Saito, Y. Tanaka, Oliver Busch, Yasuo Miake, Hideki Hamagaki, G. David, Takao Sakaguchi, S.H. Hwang, N. Xu, Maya Hachiya Shimomura, and Pranab Saha

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, High Energy Physics::Lattice, High Energy Physics::Phenomenology, Nuclear Theory, 0103 physical sciences, Physics::Accelerator Physics, Nuclear Experiment, 010306 general physics, 01 natural sciences
Abstract

XXVIIth International Conference on Ultrarelativistic Nucleus–Nucleus Collisions (Quark Matter 2018)

Published
2019
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40. P2.11-43 Management of Pulmonary Nodules Detected on CT: Multicenter Collaborative Study in Nagasaki Prefecture

Author

K. Kuroda, T. Fukuda, Masaaki Fukuda, Hiroko Hayashi, Shin Tsutsui, Y. Ogihara, M. Mori, Hiroshi Mukae, S. Yoshida, K Minami, K. Fukushima, Kazuto Ashizawa, Takeshi Nagayasu, A Fukushima, Hiroshi Takatani, Konosuke Morimoto, and Hiroyuki Yamaguchi

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Oncology, business.industry, medicine, Radiology, business
Published
2019
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41. PF748 ENTEROCOCCUS-PREDOMINANT INTESTINAL MICROBIOTA INDICATES POOR PROGNOSIS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

Author

Y. Doi, Takafumi Yokota, Y. Kanakura, K. Fukushima, A. Hino, H. Shibayama, Y. Nagate, D. Motooka, Shinsuke Kusakabe, Jiro Fujita, S. Nakamura, and R. Nakai

Subjects
Poor prognosis, Enterococcus, biology, business.industry, medicine.medical_treatment, Cancer research, medicine, Hematology, Hematopoietic stem cell transplantation, biology.organism_classification, business
Published
2019
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42. Moderated Poster Session 4: Monday 4 May 2015, 15:30-16:30 * Room: Moderated Poster Area

Author

R. A. Werner, Y. Maya, T. Yamane, C. Rischpler, K. Fukushima, X. Chen, C. Lapa, K. Herrmann, T. Higuchi, S. Thorn, M. Stacy, B. Purcell, H. Doviak, J. Shuman, E. Perez, J. Burdick, F. Spinale, A. Sinusas, T. Treibel, S. Bandula, M. Fontana, S. White, J. Gilbertson, S. Punwani, J. Gillmore, P. Hawkins, S. Taylor, J. Moon, F. Caobelli, T. Wollenweber, C. Kuehn, U. Bavendiek, C. Schuetze, L. Geworski, J. Bauersachs, A. Haverich, F. Bengel, N. Barysheva, I. Merkulova, M. Shabanova, S. Gaman, T. Veselova, M. Shariya, A. D. Kelion, M. Pakkal, F. Chowdhury, N. Nagaraj, J. Birchall, K. Dixon, W. Banya, G. Mccann, A. Gershlick, R. Dirschinger, S. Nicolosi, H. Kossmann, A. Meinicke, F. Hanus, K. Goetze, K. Laugwitz, M. Schwaiger, and S. Nekolla

Subjects
business.industry, Applied psychology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2015
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43. Magnetic phase diagram of Ni2Mn1.44−xCuxSn0.56 shape memory alloys

Author

Katsunari Oikawa, T. Miura, Tetsuo Shoji, Rie Y. Umetsu, K. Fukushima, Hironori Nishihara, Ryosuke Kainuma, K. Ohtsuki, K.R.A. Ziebeck, Wataru Ito, Takeshi Kanomata, K. Endo, and Yoshiya Adachi

Subjects
Austenite, Materials science, Condensed matter physics, Mechanical Engineering, Metals and Alloys, Paramagnetism, Magnetization, Magnetic shape-memory alloy, Mechanics of Materials, Phase (matter), Martensite, Materials Chemistry, Curie temperature, Phase diagram
Abstract

Magnetization measurements have been carried out on the magnetic shape memory alloys (MSMAs) Ni2Mn1.44−xCuxSn0.56 (0 ⩽ x ⩽ 0.09). On the basis of the experimental results, the phase diagram of Ni2Mn1.44−xCuxSn0.56 (0 ⩽ x ⩽ 0.09) alloys in the temperature-concentration plane has been determined. The resultant phase diagram is spanned by paramagnetic austenite (Para-A), ferromagnetic austenite (Ferro-A) and ferromagnetic martensite (Ferro-M) phases. The martensitic transition temperature TM makes a broad maximum as a function of x, whereas, in the austenite phase the Curie temperature TC decreases slightly with x. The TC of Ni2Mn1.415Cu0.025Sn0.56 was found to decrease linearly with pressure, whereas TM increased linearly with pressure. The values of dTM/dp and dTC/dp of Ni2Mn1.415Cu0.025Sn0.56 were found to be 0.88 K/kbar and −0.31 K/kbar, respectively.

Published
2014
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44. Club35 Poster Session Thursday 12 December: 12/12/2013, 08:30-18:00 * Location: Poster area

Author

M. Montoro Lopez, A. Iniesta Manjavacas, R. Mori Junco, L. Pena Conde, I. Pons De Antonio, S. Garcia Blas, T. Lopez Fernandez, R. Moreno Gomez, M. Moreno Yanguela, J. Lopez Sendon, A. Carro, A. Kiotsekoglou, J. Andoh, S. Brown, J. Kaski, Y. Imamura, K. Arai, S. Uematsu, K. Fukushima, H. Hoshi, K. Ashihara, A. Takagi, N. Hagiwara, K. Gillis, G. Bala, B. Roosens, I. Remory, S. Droogmans, G. Van Camp, B. Cosyns, C. Van De Heyning, J. Magne, L. Pierard, P. Bruyere, L. Davin, C. De Maeyer, B. Paelinck, C. Vrints, P. Lancellotti, A. Borowiec, R. Dabrowski, I. Kowalik, B. Firek, T. Chwyczko, J. Janas, H. Szwed, V. Tufaro, G. Fragasso, G. Ingallina, C. Marini, A. Fisicaro, F. Loiacono, A. Margonato, E. Agricola, F. Ferreira, T. Pereira, J. Abreu, J. Labandeiro, A. Fiarresga, A. Ferreira, A. Galrinho, L. Branco, A. Timoteo, R. Ferreira, R. Marmol, M. Gomez, K. Garcia, D. Sanmiguel, C. Cabades, M. Monteagudo, C. Nunez, C. Fernandez, J. Diez, I. Roldan, M. Kolesnyk, M. Ancona, M. Oppizzi, M. Krestjyaninov, V. Razin, R. Gimaev, M. Carminati, C. Piazzese, W. Tsang, R. Lang, E. Caiani, S. Goncalves, A. Ramalho, R. Placido, L. Marta, N. Cortez Dias, A. Magalhaes, M. Menezes, S. Martins, A. Almeida, A. Nunes Diogo, T. M. Stokke, V. Ruddox, S. I. Sarvari, J. E. Otterstad, E. Aune, T. Edvardsen, D. Pirone, V. De Francesco, F. Marino, F. Gervasi, C. Demartini, C. Goffredo, M. Bono, S. Mega, M. Chello, G. Di Sciascio, M. Martin Hidalgo, T. Seoane Garcia, F. Carrasco Avalos, M. Mesa Rubio, M. Delgado Ortega, M. Ruiz Ortiz, F. Mazuelos Bellido, J. Suarez De Lezo Herrero De Tejada, M. Pan Alvarez De Osorio, J. Suarez De Lezo Cruz Conde, A. Lopez Granados, M. Romero Moreno, M. Pan Alvarez-Ossorio, F. Menichetti, M. Bongiorni, B. Ferro, L. Segreti, P. Bertini, R. Mariotti, R. Baldassarri, A. Di Cori, G. Zucchelli, F. Guarracino, A. Santoro, F. Federco Alvino, G. Giovanni Antonelli, R. Raffaella De Vito, R. Roberta Molle, S. Sergio Mondillo, Y. Mahmoud, M. Abdel-Kader, R. Guindy, S. Elzahwy, E. Dijkema, M. Molenschot, M. Slieker, C. Oliveira Da Silva, A. Sahlen, R. Winter, M. Back, A. Ruck, M. Settergren, A. Manouras, K. Shahgaldi, and V. Ruzov

Subjects
Medical education, business.industry, Thursday, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2013
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45. Modeling of the Impurity-Gradient Effect in High-Voltage Laterally Diffused MOSFETs

Author

Masataka Miyake, Hideyuki Kikuchihara, Arata Tanaka, K. Fukushima, Mitiko Miura-Mattausch, Takahiro Iizuka, T. Sakuda, and Hans Jurgen Mattausch

Subjects
Materials science, Condensed matter physics, Channel length modulation, Doping, Analytical chemistry, Short-channel effect, High voltage, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Capacitance, Electronic, Optical and Magnetic Materials, Impurity, MOSFET, Condensed Matter::Strongly Correlated Electrons, Electrical and Electronic Engineering, Voltage
Abstract

MOSFET capacitance values in high-voltage laterally diffused MOSFETs, including the channel impurity concentration, which tails off along the channel from the source side to the drain side, are investigated. This pertinent doping inhomogeneity of the intrinsic MOSFET channel induces an additional electrostatic contribution to the amount of internal charges. With an emphasis on the deviations from homogeneous impurity-profile settings, the additional contribution was formulated within the framework of compact MOSFET models based on the surface-potential description. The developed capacitance-model enhancement requires a solution for the drain-side potentials at two uniform impurity concentrations, each of which corresponds to the source-side and the drain-side concentration of the impurity profile with gradient, respectively. The developed approach is found successful for all drain-source voltages, where the resulting high-voltage MOSFET-specific features are observed.

Published
2013
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46. Abstracts

Author

V. Dunet, A. Dabiri, G. Allenbach, A. Goyeneche Achigar, B. Waeber, F. Feihl, R. Heinzer, J. O. Prior, J. E. Van Velzen, J. D. Schuijf, F. R. De Graaf, M. A. De Graaf, M. J. Schalij, L. J. Kroft, A. De Roos, J. W. Jukema, E. E. Van Der Wall, J. J. Bax, E. Lankinen, A. Saraste, T. Noponen, R. Klen, M. Teras, T. Kokki, S. Kajander, M. Pietila, H. Ukkonen, J. Knuuti, A. P. Pazhenkottil, R. N. Nkoulou, J. R. Ghadri, B. A. Herzog, R. R. Buechel, S. M. Kuest, M. Wolfrum, O. Gaemperli, L. Husmann, P. A. Kaufmann, D. Andreini, G. Pontone, S. Mushtaq, L. Antonioli, E. Bertella, A. Formenti, S. Cortinovis, G. Ballerini, C. Fiorentini, M. Pepi, A. S. Koh, J. S. Flores, F. Y. J. Keng, R. S. Tan, T. S. J. Chua, A. D. Annoni, G. Tamborini, M. Fusari, A. L. Bartorelli, S. H. Ewe, A. C. T. Ng, V. Delgado, J. Schuijf, F. Van Der Kley, A. Colli, A. De Weger, N. A. Marsan, K. H. Yiu, A. C. Ng, S. A. J. Timmer, P. Knaapen, T. Germans, P. A. Dijkmans, M. Lubberink, J. M. Ten Berg, F. J. Ten Cate, I. K. Russel, A. A. Lammertsma, A. C. Van Rossum, Y. Y. Wong, G. Ruiter, P. Raijmakers, W. J. Van Der Laarse, N. Westerhof, A. Vonk-Noordegraaf, G. Youssef, E. Leung, G. Wisenberg, C. Marriot, K. Williams, J. Etele, R. A. Dekemp, J. Dasilva, D. Birnie, R. S. B. Beanlands, R. C. Thompson, A. H. Allam, L. S. Wann, A. H. Nureldin, G. Adelmaksoub, I. Badr, M. L. Sutherland, J. D. Sutherland, M. I. Miyamoto, G. S. Thomas, H. J. Harms, S. De Haan, M. C. Huisman, R. C. Schuit, A. D. Windhorst, C. Allaart, A. J. Einstein, T. Khawaja, C. Greer, A. Chokshi, M. Jones, K. Schaefle, K. Bhatia, D. Shimbo, P. C. Schulze, A. Srivastava, R. Chettiar, J. Moody, C. Weyman, D. Natale, W. Bruni, Y. Liu, E. Ficaro, A. J. Sinusas, A. Peix, E. Batista, L. O. Cabrera, K. Padron, L. Rodriguez, B. Sainz, V. Mendoza, R. Carrillo, Y. Fernandez, E. Mena, A. Naum, T. Bach-Gansmo, N. Kleven-Madsen, M. Biermann, B. Johnsen, J. Aase Husby, S. Rotevatn, J. E. Nordrehaug, J. Schaap, R. M. Kauling, M. C. Post, B. J. W. M. Rensing, J. F. Verzijlbergen, J. Sanchez, G. Giamouzis, N. Tziolas, P. Georgoulias, G. Karayannis, A. Chamaidi, N. Zavos, K. Koutrakis, G. Sitafidis, J. Skoularigis, F. Triposkiadis, S. Radovanovic, A. Djokovic, D. V. Simic, M. Krotin, A. Savic-Radojevic, M. Pljesa-Ercegovac, M. Zdravkovic, J. Saponjski, S. Jelic, T. Simic, R. Eckardt, B. J. Kjeldsen, L. I. Andersen, T. Haghfelt, P. Grupe, A. Johansen, B. Hesse, H. Pena, G. Cantinho, M. Wilk, Y. Srour, F. Godinho, N. Zafrir, A. Gutstein, I. Mats, A. Battler, A. Solodky, E. Sari, N. Singh, A. Vara, A. M. Peters, A. De Belder, S. Nair, N. Ryan, R. James, S. Dizdarevic, G. Depuey, M. Friedman, R. Wray, R. Old, H. Babla, B. Chuanyong, J. Maddahi, E. Tragardh Johansson, K. Sjostrand, L. Edenbrandt, S. Aguade-Bruix, G. Cuberas-Borros, M. N. Pizzi, M. Sabate-Fernandez, G. De Leon, D. Garcia-Dorado, J. Castell-Conesa, J. Candell-Riera, D. Casset-Senon, M. Edjlali-Goujon, D. Alison, A. Delhommais, P. Cosnay, C. S. Low, A. Notghi, J. O'brien, A. C. Tweddel, N. Bingham, P. O Neil, M. Harbinson, O. Lindner, W. Burchert, M. Schaefers, C. Marcassa, R. Campini, P. Calza, O. Zoccarato, A. Kisko, J. Kmec, M. Babcak, M. Vereb, M. Vytykacova, J. Cencarik, P. Gazdic, J. Stasko, A. Abreu, E. Pereira, L. Oliveira, P. Colarinha, V. Veloso, I. Enriksson, G. Proenca, P. Delgado, L. Rosario, J. Sequeira, I. Kosa, I. Vassanyi, C. S. Egyed, G. Y. Kozmann, S. Morita, M. Nanasato, I. Nanbu, Y. Yoshida, H. Hirayama, A. Allam, A. Sharef, I. Shawky, M. Farid, M. Mouden, J. P. Ottervanger, J. R. Timmer, M. J. De Boer, S. Reiffers, P. L. Jager, S. Knollema, G. M. Nasr, M. Mohy Eldin, M. Ragheb, I. Casans-Tormo, R. Diaz-Exposito, F. J. Hurtado-Mauricio, R. Ruano, M. Diego, F. Gomez-Caminero, C. Albarran, A. Martin De Arriba, A. Rosero, R. Lopez, C. Martin Luengo, J. R. Garcia-Talavera, I. E. K. Laitinen, M. Rudelius, E. Weidl, G. Henriksen, H. J. Wester, M. Schwaiger, X. B. Pan, T. Schindler, A. Quercioli, H. Zaidi, O. Ratib, J. M. Declerck, E. Alexanderson Rosas, R. Jacome, M. Jimenez-Santos, E. Romero, M. A. Pena-Cabral, A. Meave, J. Gonzalez, F. Rouzet, L. Bachelet, J. M. Alsac, M. Suzuki, L. Louedec, A. Petiet, F. Chaubet, D. Letourneur, J. B. Michel, D. Le Guludec, A. Aktas, A. Cinar, G. Yaman, T. Bahceci, K. Kavak, A. Gencoglu, A. Jimenez-Heffernan, E. Sanchez De Mora, J. Lopez-Martin, R. Lopez-Aguilar, C. Ramos, C. Salgado, A. Ortega, C. Sanchez-Gonzalez, J. Roa, A. Tobaruela, S. V. Nesterov, O. Turta, M. Maki, C. Han, D. Daou, M. Tawileh, S. O. Chamouine, C. Coaguila, E. Mariscal-Labrador, N. Kisiel-Gonzalez, P. De Araujo Goncalves, P. J. Sousa, H. Marques, J. O'neill, J. Pisco, R. Cale, J. Brito, A. Gaspar, F. P. Machado, J. Roquette, M. Martinez, G. Melendez, E. Kimura, J. M. Ochoa, A. M. Alessio, A. Patel, R. Lautamaki, F. M. Bengel, J. B. Bassingthwaighte, J. H. Caldwell, K. Rahbar, H. Seifarth, M. Schafers, L. Stegger, T. Spieker, A. Hoffmeier, D. Maintz, H. Scheld, O. Schober, M. Weckesser, H. Aoki, I. Matsunari, K. Kajinami, M. Martin Fernandez, M. Barreiro Perez, O. V. Fernandez Cimadevilla, D. Leon Duran, E. Velasco Alonso, J. P. Florez Munoz, L. H. Luyando, C. Templin, C. E. Veltman, J. H. C. Reiber, S. Venuraju, A. Yerramasu, S. Atwal, A. Lahiri, T. Kunimasa, M. Shiba, K. Ishii, J. Aikawa, E. S. J. Kroner, K. T. Ho, Q. W. Yong, K. C. Chua, C. Panknin, C. J. Roos, J. M. Van Werkhoven, A. J. Witkowska-Grzeslo, M. J. Boogers, D. V. Anand, D. Dey, D. Berman, F. Mut, R. Giubbini, L. Lusa, T. Massardo, A. Iskandrian, M. Dondi, A. Sato, Y. Kakefuda, E. Ojima, T. Adachi, A. Atsumi, T. Ishizu, Y. Seo, M. Hiroe, K. Aonuma, M. Kruk, R. Pracon, C. Kepka, J. Pregowski, A. Kowalewska, M. Pilka, M. Opolski, I. Michalowska, Z. Dzielinska, M. Demkow, V. Stoll, N. Sabharwal, A. Chakera, O. Ormerod, H. Fernandes, M. Bernardes, E. Martins, P. Oliveira, T. Vieira, G. Terroso, A. Oliveira, T. Faria, F. Ventura, J. Pereira, S. Fukuzawa, M. Inagaki, J. Sugioka, A. Ikeda, S. Okino, J. Maekawa, T. Uchiyama, N. Kamioka, S. Ichikawa, M. Afshar, R. Alvi, N. Aguilar, R. Ippili, H. Shaqra, J. Bella, N. Bhalodkar, A. Dos Santos, M. Daicz, L. O. Cendoya, H. G. Marrero, J. Casuscelli, M. Embon, G. Vera Janavel, E. Duronto, E. P. Gurfinkel, C. M. Cortes, Y. Takeishi, K. Nakajima, Y. Yamasaki, T. Nishimura, K. Hayes Brown, F. Collado, M. Alhaji, J. Green, S. Alexander, R. Vashistha, S. Jain, F. Aldaas, J. Shanes, R. Doukky, K. Ashikaga, Y. J. Akashi, M. Uemarsu, R. Kamijima, K. Yoneyama, K. Omiya, Y. Miyake, Y. Brodov, U. Raval, A. Berezin, V. Seden, E. Koretskaya, T. A. Panasenko, S. Matsuo, S. Kinuya, J. Chen, R. J. Van Bommel, B. Van Der Hiel, P. Dibbets-Schneider, E. V. Garcia, I. Rutten-Vermeltfoort, M. M. J. Gevers, B. Verhoeven, A. B. Dijk Van, E. Raaijmakers, P. G. H. M. Raijmakers, J. E. Engvall, M. Gjerde, J. De Geer, E. Olsson, P. Quick, A. Persson, M. Mazzanti, M. Marini, L. Pimpini, G. P. Perna, C. Marciano, P. Gargiulo, M. Galderisi, C. D'amore, G. Savarese, L. Casaretti, S. Paolillo, A. Cuocolo, P. Perrone Filardi, M. Al-Amoodi, E. C. Thompson, K. Kennedy, K. A. Bybee, A. I. Mcghie, J. H. O'keefe, T. M. Bateman, R. L. F. Van Der Palen, A. M. Mavinkurve-Groothuis, B. Bulten, L. Bellersen, H. W. M. Van Laarhoven, L. Kapusta, L. F. De Geus-Oei, P. P. Pollice, M. B. Bonifazi, F. P. Pollice, I. P. Clements, D. O. Hodge, C. G. Scott, M. De Ville De Goyet, B. Brichard, T. Pirotte, S. Moniotte, R. A. Tio, A. Elvan, R. A. I. O. Dierckx, R. H. J. A. Slart, T. Furuhashi, M. Moroi, H. Hase, N. Joki, H. Masai, R. Nakazato, H. Fukuda, K. Sugi, K. Kryczka, E. Kaczmarska, J. Petryka, L. Mazurkiewicz, W. Ruzyllo, P. Smanio, E. Vieira Segundo, M. Siqueira, J. Kelendjian, J. Ribeiro, J. Alaca, M. Oliveira, F. Alves, I. Peovska, J. Maksimovic, M. Vavlukis, N. Kostova, D. Pop Gorceva, V. Majstorov, M. Zdraveska, S. Hussain, M. Djearaman, E. Hoey, L. Morus, O. Erinfolami, A. Macnamara, M. P. Opolski, A. Witkowski, V. Berti, F. Ricci, R. Gallicchio, W. Acampa, G. Cerisano, C. Vigorito, R. Sciagra', A. Pupi, H. Sliem, F. M. Collado, S. Schmidt, A. Maheshwari, R. Kiriakos, V. Mwansa, S. Ljubojevic, S. Sedej, M. Holzer, G. Marsche, V. Marijanski, J. Kockskaemper, B. Pieske, A. Ricalde, G. Alexanderson, A. Mohani, P. Khanna, A. Sinusas, F. Lee, V. A. Pinas, B. L. F. Van Eck-Smit, H. J. Verberne, C. M. De Bruin, G. Guilhermina, L. Jimenez-Angeles, O. Ruiz De Jesus, O. Yanez-Suarez, E. Vallejo, E. Reyes, M. Chan, M. L. Hossen, S. R. Underwood, A. Karu, S. Bokhari, V. Pineda, L. M. Gracia-Sanchez, A. Garcia-Burillo, K. Zavadovskiy, Y. U. Lishmanov, W. Saushkin, I. Kovalev, A. Chernishov, A. Annoni, M. Tarkia, T. Saanijoki, V. Oikonen, T. Savunen, M. A. Green, M. Strandberg, A. Roivainen, M. C. Gaeta, C. Artigas, J. Deportos, L. Geraldo, A. Flotats, V. La Delfa, I. Carrio, W. J. Laarse, M. M. Izquierdo Gomez, J. Lacalzada Almeida, A. Barragan Acea, A. De La Rosa Hernandez, R. Juarez Prera, G. Blanco Palacios, J. A. Bonilla Arjona, J. J. Jimenez Rivera, J. L. Iribarren Sarrias, I. Laynez Cerdena, A. Dedic, A. Rossi, G. J. R. Ten Kate, A. Dharampal, A. Moelker, T. W. Galema, N. Mollet, P. J. De Feyter, K. Nieman, D. Trabattoni, A. Broersen, M. Frenay, M. M. Boogers, P. H. Kitslaar, J. Dijkstra, D. A. Annoni, M. Muratori, N. Johki, M. Tokue, A. S. Dharampal, A. C. Weustink, L. A. E. Neefjes, S. L. Papadopoulou, C. Chen, N. R. A. Mollet, E. H. Boersma, G. P. Krestin, J. A. Purvis, D. Sharma, S. M. Hughes, D. S. Berman, R. Taillefer, J. Udelson, M. Devine, J. Lazewatsky, G. Bhat, D. Washburn, D. Patel, T. Mazurek, S. Tandon, S. Bansal, S. Inzucchi, L. Staib, J. Davey, D. Chyun, L. Young, F. Wackers, M. T. Harbinson, G. Wells, J. Dougan, S. Borges-Neto, H. Phillips, A. Farzaneh-Far, Z. Starr, L. K. Shaw, M. Fiuzat, C. O'connor, M. Henzlova, W. L. Duvall, A. Levine, U. Baber, L. Croft, S. Sahni, S. Sethi, L. Hermann, A. Nureldin, A. Gomaa, M. A. T. Soliman, H. A. R. Hany, F. De Graaf, A. Pazhenkottil, H. M. J. Siebelink, J. H. Reiber, M. Ayub, T. Naveed, M. Azhar, A. Van Tosh, T. L. Faber, J. R. Votaw, N. Reichek, B. Pulipati, C. Palestro, K. J. Nichols, K. Okuda, Y. Kirihara, T. Ishikawa, J. Taki, M. Yoshita, M. Yamada, A. Salacata, S. Keavey, V. Chavarri, J. Mills, H. Nagaraj, P. Bhambhani, D. E. Kliner, P. Soman, J. Heo, A. E. Iskandrian, M. Jain, B. Lin, A. Walker, C. Nkonde, S. Bond, A. Baskin, J. Declerck, M. E. Soto, G. Mendoza, M. Aguilar, S. P. Williams, G. Colice, J. R. Mcardle, A. Lankford, D. K. Kajdasz, C. R. Reed, L. Angelini, F. Angelozzi, G. Ascoli, A. Jacobson, H. J. Lessig, M. C. Gerson, M. D. Cerqueira, J. Narula, M. Uematsu, K. Kida, K. Suzuki, P. E. Bravo, K. Fukushima, M. Chaudhry, J. Merrill, A. Alonso Tello, J. F. Rodriguez Palomares, G. Marti Aguasca, S. Aguade Bruix, V. Aliaga, P. Mahia, T. Gonzalez-Alujas, J. Candell, A. Evangelista, R. Mlynarski, A. Mlynarska, M. Sosnowski, B. Zerahn, P. Hasbak, C. E. Mortensen, H. F. Mathiesen, M. Andersson, D. Nielsen, L. Ferreira Santos, M. J. Ferreira, D. Ramos, D. Moreira, M. J. Cunha, A. Albuquerque, A. Moreira, J. Oliveira Santos, G. Costa, L. A. Providencia, Y. Arita, S. Kihara, N. Mitsusada, M. Miyawaki, H. Ueda, H. Hiraoka, Y. Matsuzawa, J. Askew, M. O'connor, L. Jordan, R. Ruter, R. Gibbons, T. Miller, L. Emmett, A. Ng, N. Sorensen, R. Mansberg, L. Kritharides, T. Gonzalez, H. Majmundar, N. P. Coats, S. Vernotico, J. H. Doan, T. M. Hernandez, M. Evini, A. D. Hepner, T. K. Ip, W. A. Chalela, A. M. Falcao, L. O. Azouri, J. A. F. Ramires, J. C. Meneghetti, F. Manganelli, M. Spadafora, P. Varrella, G. Peluso, R. Sauro, E. Di Lorenzo, F. Rotondi, S. Daniele, P. Miletto, A. J. M. Rijnders, B. W. Hendrickx, W. Van Der Bruggen, Y. G. C. J. America, P. J. Thorley, F. U. Chowdhury, C. J. Dickinson, S. I. Sazonova, I. Y. U. Proskokova, A. M. Gusakova, S. M. Minin, Y. U. B. Lishmanov, V. V. Saushkin, G. Rodriguez, F. Roffe, H. Ilarraza, D. Bialostozky, A. N. Kitsiou, P. Arsenos, I. Tsiantis, S. Charizopoulos, S. Karas, R. C. Vidal Perez, M. Garrido, V. Pubul, S. Argibay, C. Pena, M. Pombo, A. B. Ciobotaru, A. Sanchez-Salmon, A. Ruibal Morell, J. R. Gonzalez-Juanatey, E. Rodriguez-Gomez, B. Martinez, D. Pontillo, F. Benvissuto, F. Fiore Melacrinis, S. Maccafeo, E. V. Scabbia, R. Schiavo, Y. Golzar, C. Gidea, J. Golzar, D. Pop-Gorceva, M. Zdravkovska, S. Stojanovski, L. J. Georgievska-Ismail, T. Katsikis, A. Theodorakos, A. Kouzoumi, M. Koutelou, Y. Yoshimura, T. Toyama, H. Hoshizaki, S. Ohshima, M. Inoue, T. Suzuki, A. Uitterdijk, M. Dijkshoorn, M. Van Straten, W. J. Van Der Giessen, D. J. Duncker, D. Merkus, G. Platsch, J. Sunderland, C. Tonge, P. Arumugam, T. Dey, H. Wieczorek, R. Bippus, R. L. Romijn, B. E. Backus, T. Aach, M. Lomsky, L. Johansson, J. Marving, S. Svensson, J. L. Pou, F. P. Esteves, P. Raggi, R. Folks, Z. Keidar, J. W. Askew, L. Verdes, L. Campos, V. Gulyaev, A. Pankova, J. Santos, S. Carmona, I. Henriksson, A. Prata, M. Carrageta, A. I. Santos, K. Yoshinaga, M. Naya, C. Katoh, O. Manabe, S. Yamada, H. Iwano, S. Chiba, H. Tsutsui, N. Tamaki, I. Vassiliadis, E. Despotopoulos, O. Kaitozis, E. Hatzistamatiou, R. Thompson, J. Hatch, M. Zink, B. S. Gu, G. D. Bae, C. M. Dae, G. H. Min, E. J. Chun, S. I. Choi, M. Al-Mallah, K. Kassem, O. Khawaja, D. Goodman, D. Lipkin, L. Christiaens, B. Bonnet, J. Mergy, D. Coisne, J. Allal, N. Dias Ferreira, D. Leite, J. Rocha, M. Carvalho, D. Caeiro, N. Bettencourt, P. Braga, V. Gama Ribeiro, U. S. Kristoffersen, A. M. Lebech, H. Gutte, R. S. Ripa, N. Wiinberg, C. L. Petersen, G. Jensen, A. Kjaer, C. Bai, R. Conwell, R. D. Folks, L. Verdes-Moreiras, D. Manatunga, A. F. Jacobson, D. Belzer, Y. Hasid, M. Rehling, R. H. Poulsen, L. Falborg, J. T. Rasmussen, L. N. Waehrens, C. W. Heegaard, J. M. U. Silvola, S. Forsback, J. O. Laine, S. Heinonen, S. Ylaherttuala, A. Broisat, M. Ruiz, N. C. Goodman, J. Dimastromatteo, D. K. Glover, F. Hyafil, F. Blackwell, G. Pavon-Djavid, L. Sarda-Mantel, L. J. Feldman, A. Meddahi-Pelle, V. Tsatkin, Y.- H. Liu, R. De Kemp, P. J. Slomka, R. Klein, G. Germano, R. S. Beanlands, A. Rohani, V. Akbari, J. G. J. Groothuis, M. Fransen, A. M. Beek, S. L. Brinckman, M. R. Meijerink, M. B. M. Hofman, C. Van Kuijk, S. Kogure, E. Yamashita, J. Murakami, R. Kawaguchi, H. Adachi, S. Oshima, S. Minin, S. Popov, Y. U. Saushkina, G. Savenkova, D. Lebedev, E. Alexandridis, D. Rovithis, C. Parisis, I. Sazonova, V. Saushkin, V. Chernov, L. Zaabar, H. Bahri, S. Hadj Ali, A. Sellem, I. Slim, N. El Kadri, H. Slimen, H. Hammami, S. Lucic, A. Peter, S. Tadic, K. Nikoletic, R. Jung, M. Lucic, K. Tagil, D. Jakobsson, S.- E. Svensson, P. Wollmer, L. Leccisotti, L. Indovina, L. Paraggio, M. L. Calcagni, A. Giordano, M. Kapitan, A. Paolino, M. Nunez, J. Sweeny, N. Kulkarni, K. Guma, Y. Akashi, M. Takano, M. Takai, S. Koh, F. Miyake, N. Torun, G. Durmus Altun, A. Altun, E. Kaya, H. Saglam, D. T. Matsuoka, A. Sanchez, C. Bartolozzi, D. Padua, G. Ponta, A. Ponte, A. Carneiro, A. Thom, R. Ashrafi, P. Garg, G. Davis, A. Falcao, M. Costa, F. Bussolini, J. A. C. Meneghetti, M. Tobisaka, E. Correia, J. W. Jansen, P. A. Van Der Vleuten, T. P. Willems, F. Zijlstra, M. Sato, K. Taniguchi, M. Kurabayashi, D. Pop Gjorcheva, M. Zdraveska-Kochovska, K. Moriwaki, A. Kawamura, K. Watanabe, T. Omura, S. Sakabe, T. Seko, A. Kasai, M. Ito, M. Obana, T. Akasaka, C. Hruska, D. Truong, C. Pletta, D. Collins, C. Tortorelli, D. Rhodes, M. El-Prince, A. Martinez-Moeller, M. Marinelli, S. Weismueller, C. Hillerer, B. Jensen, S. G. Nekolla, H. Wakabayashi, K. Tsukamoto, S. M. E. A. Baker, K. M. H. S. Sirajul Haque, A. Siddique, S. Krishna Banarjee, A. Ahsan, F. Rahman, M. Mukhlesur Rahman, T. Parveen, M. Lutfinnessa, F. Nasreen, H. Sano, S. Naito, M. L. De Rimini, G. Borrelli, F. Baldascino, P. Calabro, C. Maiello, A. Russo, C. Amarelli, P. Muto, I. Danad, P. G. Raijmakers, Y. E. Appelman, O. S. Hoekstra, J. T. Marcus, A. Boonstra, D. V. Ryzhkova, T. V. Kuzmina, O. S. Borodina, M. A. Trukshina, I. S. Kostina, H. Hommel, G. Feuchtner, O. Pachinger, G. Friedrich, A. M. Stel, J. W. Deckers, V. Gama, A. Ciarka, L. A. Neefjes, N. R. Mollet, E. J. Sijbrands, J. Wilczek, C. Llibre Pallares, O. Abdul-Jawad Altisent, H. Cuellar Calabria, P. Mahia Casado, M. T. Gonzalez-Alujas, A. Evangelista Masip, D. Garcia-Dorado Garcia, Y. Tekabe, X. Shen, Q. Li, J. Luma, D. Weisenberger, A. M. Schmidt, R. Haubner, L. Johnson, L. Sleiman, S. Thorn, M. Hasu, M. Thabet, J. N. Dasilva, S. C. Whitman, D. Genovesi, A. Giorgetti, A. Gimelli, G. Cannizzaro, F. Bertagna, G. Fagioli, M. Rossi, R. Bonini, P. Marzullo, C. A. Paterson, S. A. Smith, A. D. Small, N. E. R. Goodfield, W. Martin, S. Nekolla, H. Sherif, S. Reder, M. Yu, A. Kusch, D. Li, J. Zou, M. S. Lloyd, K. Cao, D. W. Motherwell, A. Rice, G. M. Mccurrach, S. M. Cobbe, M. C. Petrie, I. Al Younis, E. Van Der Wall, T. Mirza, M. Raza, H. Hashemizadeh, L. Santos, B. A. Krishna, F. Perna, M. Lago, M. Leo, G. Pelargonio, G. Bencardino, M. L. Narducci, M. Casella, F. Bellocci, S. Kirac, O. Yaylali, M. Serteser, T. Yaylali, A. Okizaki, Y. Urano, M. Nakayama, S. Ishitoya, J. Sato, Y. Ishikawa, M. Sakaguchi, N. Nakagami, T. Aburano, S. V. Solav, R. Bhandari, S. Burrell, S. Dorbala, I. Bruno, C. Caldarella, A. Collarino, M. V. Mattoli, A. Stefanelli, A. Cannarile, F. Maggi, V. Soukhov, S. Bondarev, A. Yalfimov, M. Khan, P. P. Priyadharshan, G. Chandok, T. Aziz, M. Avison, R. A. Smith, D. S. Bulugahapitya, T. Vakhtangadze, F. Todua, M. Baramia, G. Antelava, N.- C. Roche, P. Paule, S. Kerebel, J.- M. Gil, L. Fourcade, A. Tzonevska, K. Tzvetkov, M. Atanasova, V. Parvanova, A. Chakarova, E. Piperkova, B. Kocabas, H. Muderrisoglu, C. P. Allaart, E. Entok, S. Simsek, B. Akcay, I. Ak, E. Vardareli, M. Stachura, P. J. Kwasiborski, G. J. Horszczaruk, E. Komar, A. Cwetsch, B. Zraik, R. Morales Demori, A. D. J. Almeida, M. E. Siqueira, E. Vieira, I. Balogh, G. Kerecsen, E. Marosi, Z. S. Szelid, A. Sattar, T. Swadia, J. Chattahi, W. Qureshi, F. Khalid, A. Gonzalez, S. Hechavarria, K. Takamura, S. Fujimoto, R. Nakanishi, S. Yamashina, A. Namiki, J. Yamazaki, K. Koshino, Y. Hashikawa, N. Teramoto, M. Hikake, S. Ishikane, T. Ikeda, H. Iida, Y. Takahashi, N. Oriuchi, H. Higashino, K. Endo, T. Mochizuki, K. Murase, A. Baali, R. Moreno, M. Chau, H. Rousseau, F. Nicoud, P. Dolliner, L. Brammen, G. Steurer, T. Traub-Weidinger, P. Ubl, P. Schaffarich, G. Dobrozemsky, A. Staudenherz, M. Ozgen Kiratli, B. Temelli, N. B. Kanat, T. Aksoy, G. A. Slavich, G. Piccoli, M. Puppato, S. Grillone, D. Gasparini, S. Perruchoud, C. Poitry-Yamate, M. Lepore, R. Gruetter, T. Pedrazzini, D. Anselm, A. Anselm, H. Atkins, J. Renaud, R. Dekemp, I. Burwash, A. Guo, R. Beanlands, C. Glover, I. Vilardi, B. Zangheri, L. Calabrese, P. Romano, A. Bruno, O. C. Fernandez Cimadevilla, V. A. Uusitalo, M. Luotolahti, M. Wendelin-Saarenhovi, J. Sundell, O. Raitakari, S. Huidu, R. Gadiraju, M. Ghesani, Q. Uddin, B. Wosnitzer, N. Takahashi, E. Alhaj, A. Legasto, B. Abiri, K. Elsaban, T. El Khouly, T. El Kammash, A. Al Ghamdi, B. Kyung Deok, K. Bon Seung, Y. Sang Geun, D. Chang Min, and M. Gwan Hong

Subjects
Cardiology and Cardiovascular Medicine
Published
2011
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47. Magnetic properties of Mn-rich Ni2MnSn Heusler alloys under pressure

Author

Kazuyuki Matsubayashi, Takeshi Kanomata, Ryosuke Kainuma, T. Shishido, Y. Chieda, K. Fukushima, Katsunari Oikawa, Kazuo Obara, Kiyohito Ishida, and Yoshiya Uwatoko

Subjects
Condensed matter physics, Mechanics of Materials, Chemistry, Permeability (electromagnetism), Mechanical Engineering, Initial permeability, Materials Chemistry, Metals and Alloys, Analytical chemistry, Curie temperature, Pressure derivative
Abstract

The pressure effect on the Curie temperature T C of Heusler alloys Ni 2 Mn 1+ x Sn 1− x (0 ≤ x ≤ 0.28) has been investigated by measuring the temperature dependence of initial permeability at various pressures up to 10 kbar. The pressure derivative of T C , d T C /d p , of Ni 2 MnSn is found to be +0.5 K/kbar. The values of d T C /d p for Ni 2 Mn 1+ x Sn 1− x (0 ≤ x ≤ 0.28) alloys decrease with increasing the concentration x . The pressure effect on T C for Ni 2 Mn 1+ x Sn 1− x (0 ≤ x ≤ 0.28) alloys is discussed qualitatively on the basis of the interatomic dependence of the exchange interactions.

Published
2009
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48. Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosis

Author

Michael J. McKenna, Markus Pfister, Guy Van Camp, K. Fukushima, D. J. Mcbride, Melissa Thys, Richard J.H. Smith, Nicole C. Meyer, and Wenjie Chen

Subjects
Male, Genotype, Single-nucleotide polymorphism, Human leukocyte antigen, Biology, Polymorphism, Single Nucleotide, Collagen Type I, Frameshift mutation, Mice, Genetics, medicine, Animals, Humans, Genetic Predisposition to Disease, Regulatory Elements, Transcriptional, Allele, Hearing Loss, Gene, Cells, Cultured, Genetics (clinical), Binding Sites, Haplotype, medicine.disease, Collagen Type I, alpha 1 Chain, Mice, Inbred C57BL, Otosclerosis, Haplotypes, Case-Control Studies, Female, Transcription Factors
Abstract

Otosclerosis (MIM 166800) has a prevalence of 0.2-1% among white adults, making it the single most common cause of hearing impairment in this ethnic group. Although measles virus, hormones, human leukocyte antigen alleles and genetic factors have been implicated in the development of otosclerosis, its etiology remains unknown. In a focused effort to identify genetic factors in otosclerosis, we have mapped four disease loci (MIM 166800/605727/608244/608787); however, cloning the disease-causing genes in these intervals has not been successful. Here, we used a case-control study design to investigate the association between collagen type I genes and otosclerosis. We identified susceptibility and protective haplotypes in COL1A1 that are significantly associated with otosclerosis in the Caucasian population. These haplotypes alter reporter gene activity in an osteoblast cell line by affecting binding of transcription factors to cis-acting elements. Our data suggest that increased amounts of collagen alpha1(I) homotrimers are causally related to the development of otosclerosis. Consistent with this hypothesis, mouse mutants homozygous for a Col1a2 frameshift mutation on a C57BL/6J background that deposit only homotrimeric type I collagen have hearing loss.

Published
2007
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50. High plasma concentrations of osteopontin in patients with interstitial pneumonia

Author

K. Fukushima, Toshimitsu Uede, Katsuhiko Mito, Yoshinobu Koguchi, Sumako Yoshioka, Atsushi Saito, Syunji Mizunoe, J. Kadota, Shigeyuki Kon, Kazuyoshi Kawakami, Shigeru Kohno, Masaru Nasu, and Hiroshi Mukae

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Sarcoidosis, Partial Pressure, Sialoglycoproteins, medicine.medical_treatment, Vital Capacity, Bleomycin, Sensitivity and Specificity, Immunoenzyme Techniques, chemistry.chemical_compound, Idiopathic pulmonary fibrosis, Sarcoidosis, Pulmonary, stomatognathic system, Macrophages, Alveolar, Blood plasma, Pulmonary fibrosis, medicine, Humans, Osteopontin, Aged, Interstitial pneumonia, Carbon Monoxide, Lung, biology, business.industry, Respiratory disease, Middle Aged, medicine.disease, Oxygen, Cytokine, medicine.anatomical_structure, chemistry, biology.protein, Female, Lung Diseases, Interstitial, business, Biomarkers
Abstract

Osteopontin (OPN) produced by alveolar macrophages functions as a fibrogenic cytokine in the development of bleomycin (BLM)-induced murine pulmonary fibrosis, and OPN mRNA is expressed on lung tissues from patients with idiopathic pulmonary fibrosis (IPF). The present study investigates plasma OPN levels in human interstitial pneumonia (IP) and their relationships with disease severity by analyzing the correlation between plasma OPN concentrations and pulmonary functions. The concentrations of OPN in plasma were measured in 17 patients with IP, in 9 with sarcoidosis and in 20 healthy controls using an antigen-capture enzyme-linked immunosorbent assay. The concentrations of OPN in plasma were significantly higher in IP patients than in those with sarcoidosis or in controls. Based on a Receiver Operating Characteristic curve analysis, cut-off points between 300 and 380ng/ml discriminated between IP and control subjects with 100% sensitivity and 100% specificity. In such case, the sensitivity for sarcoidosis decreased (55.5–33.3%) in cut-offs with 100% specificity. Plasma OPN levels inversely and closely correlated with arterial oxygen tension (PaO2) in patients with IP. Immunohistochemically, OPN was localized predominantly in macrophages and airway epithelium. These findings suggest that plasma OPN levels were found to be associated with the presence of IP, and that OPN play an important role in the development of IP.

Published
2005
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