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17. Protein profiling of genomic instability in endometrial cancer

Author

Gemoll, Timo, Habermann, Jens K., Lahmann, Johanna, Szymczak, Silke, Lundgren, Caroline, Bündgen, Nana K., Jungbluth, Thomas, Nordström, Britta, Becker, Susanne, Lomnytska, Marta I., Bruch, Hans-Peter, Ziegler, Andreas, Hellman, Ulf, Auer, Gert, Roblick, Uwe J., and Jörnvall, Hans

Published
2012
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45. Metachronous metastasis- and survival-analysis show prognostic importance of lymphadenectomy for colon carcinomas

Author

Laubert Tilman, Habermann Jens K, Hemmelmann Claudia, Kleemann Markus, Oevermann Elisabeth, Bouchard Ralf, Hildebrand Philipp, Jungbluth Thomas, Bürk Conny, Esnaashari Hamed, Schlöricke Erik, Hoffmann Martin, Ziegler Andreas, Bruch Hans-Peter, and Roblick Uwe J

Subjects
Colon cancer, Lymph nodes, Metastasis, Prognosis, Survival, Recurrence free survival, Regression analysis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Lymphadenectomy is performed to assess patient prognosis and to prevent metastasizing. Recently, it was questioned whether lymph node metastases were capable of metastasizing and therefore, if lymphadenectomy was still adequate. We evaluated whether the nodal status impacts on the occurrence of distant metastases by analyzing a highly selected cohort of colon cancer patients. Methods 1,395 patients underwent surgery exclusively for colon cancer at the University of Lübeck between 01/1993 and 12/2008. The following exclusion criteria were applied: synchronous metastasis, R1-resection, prior/synchronous second carcinoma, age < 50 years, positive family history, inflammatory bowel disease, FAP, HNPCC, and follow-up < 5 years. The remaining 421 patients were divided into groups with (TM+, n = 75) or without (TM-, n = 346) the occurrence of metastasis throughout a 5-year follow-up. Results Five-year survival rates for TM + and TM- were 21% and 73%, respectively (p < 0.0001). Survival rates differed significantly for N0 vs. N2, grading 2 vs. 3, UICC-I vs. -II and UICC-I vs. -III (p < 0.05). Regression analysis revealed higher age upon diagnosis, increasing N- and increasing T-category to significantly impact on recurrence free survival while increasing N-and T-category were significant parameters for the risk to develop metastases within 5-years after surgery (HR 1.97 and 1.78; p < 0.0001). Conclusions Besides a higher T-category, a positive N-stage independently implies a higher probability to develop distant metastases and correlates with poor survival. Our data thus show a prognostic relevance of lymphadenectomy which should therefore be retained until conclusive studies suggest the unimportance of lmyphadenectomy.

Published
2012
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46. Technik in der Schweinehaltung

Author

Jungbluth, Thomas

Subjects
Pig Husbandry, Precision Livestock Farming, animal welfare, emissions, ddc:6, Veröffentlichung der TU Braunschweig, ddc:63, Article, Schweinehaltung, Precision Livestock Farming, Tierschutz, Tierwohl, Emissionen
Abstract

Die Forschungstätigkeit in der Schweinehaltung fokussiert sich auf Tierschutz bzw. Tierwohl. Dazu sind neue Haltungssysteme notwendig. Entwicklungen im Bereich des Precision Livestock Farmings betreffen Technologien zum Tier- und Gesundheitsmonitoring. Hierzu sind die RFID-Technik, Sensoren, Aktoren und Rechenalgorithmen zu verbessern. Die derzeit vernachlässigte Umweltforschung wird zukünftig wieder an Bedeutung gewinnen., Research in pig husbandry focuses on animal welfare. Therefore, new housing systems are necessary. New technical developments in Precision Livestock Farming apply to animal and health monitoring; RFID-technology, sensors, actuators and algorithms are to be improved here. Research on environmental impacts of pig housing has been neglected in the recent years, but will gain importance again very soon., Jahrbuch Agrartechnik, vol. 29Jahrbuch Agrartechnik 2017, vol. 29, 2017

Published
2018
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47. The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction – a phase III trial of the German AIO/CAO-V/CAOGI

Author

Al-Batran, Salah-Eddin, primary, Goetze, Thorsten O., additional, Mueller, Daniel W., additional, Vogel, Arndt, additional, Winkler, Michael, additional, Lorenzen, Sylvie, additional, Novotny, Alexander, additional, Pauligk, Claudia, additional, Homann, Nils, additional, Jungbluth, Thomas, additional, Reissfelder, Christoph, additional, Caca, Karel, additional, Retter, Steffen, additional, Horndasch, Eva, additional, Gumpp, Julia, additional, Bolling, Claus, additional, Fuchs, Karl-Hermann, additional, Blau, Wolfgang, additional, Padberg, Winfried, additional, Pohl, Michael, additional, Wunsch, Andreas, additional, Michl, Patrick, additional, Mannes, Frank, additional, Schwarzbach, Matthias, additional, Schmalenberg, Harald, additional, Hohaus, Michael, additional, Scholz, Christian, additional, Benckert, Christoph, additional, Knorrenschild, Jorge Riera, additional, Kanngießer, Veit, additional, Zander, Thomas, additional, Alakus, Hakan, additional, Hofheinz, Ralf-Dieter, additional, Roedel, Claus, additional, Shah, Manish A., additional, Sasako, Mitsuru, additional, Lorenz, Dietmar, additional, Izbicki, Jakob, additional, Bechstein, Wolf O., additional, Lang, Hauke, additional, and Moenig, Stefan P., additional

Published
2017
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49. Multiple Karzinome

Author

Hildebrand, Philipp, Humke, Janina, Övermann, Elisabeth, Schlöricke, Erik, Jungbluth, Thomas, Roblick, Uwe, and Bruch, Hans-Peter

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Das kolorektale Karzinom ist eines der häufigsten Karzinome in der westlichen Welt. Eine Vielzahl von Prognosefaktoren wurde bereits für das kolorektale Karzinom beschrieben. Inwieweit jedoch das Auftreten von multiplen Karzinomen die Prognose des Patienten beeinflusst wurde in[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
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50. Prognose des sporadischen Kolonkarzinoms - Analyse eines hoch selektierten Patientenkollektivs

Author

Laubert, Tilman, Hemmelmann, Claudia, Kleemann, Markus, Oevermann, Elisabeth, Bürk, Conny, Jungbluth, Thomas, Ziegler, Andreas, Bruch, Hans-Peter, Roblick, Uwe Johannes, and Habermann, Jens Karsten

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Prognose des kolorektalen Karzinoms hängt vom Tumorstadium und dem möglichen Auftreten von metachronen Fernmetastasen ab. Für eine genaue Analyse der Prognose ist es essentiell, diejenigen Faktoren zu berücksichtigen, die zusätzlich einen Einfluss auf die Prognose[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011

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