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1. Five simultaneous artificial intelligence data challenges on ultrasound, CT, and MRI

Author

Lassau, N., Estienne, T., de Vomecourt, P., Azoulay, M., Cagnol, J., Garcia, G., Majer, M., Jehanno, E., Renard-Penna, R., Balleyguier, C., Bidault, F., Caramella, C., Jacques, T., Dubrulle, F., Behr, J., Poussange, N., Bocquet, J., Montagne, S., Cornelis, F., Faruch, M., Bresson, B., Brunelle, S., Jalaguier-Coudray, A., Amoretti, N., Blum, A., Paisant, A., Herreros, V., Rouviere, O., Si-Mohamed, S., Di Marco, L., Hauger, O., Garetier, M., Pigneur, F., Bergère, A., Cyteval, C., Fournier, L., Malhaire, C., Drape, J.-L., Poncelet, E., Bordonne, C., Cauliez, H., Budzik, J.-F., Boisserie, M., Willaume, T., Molière, S., Peyron Faure, N., Caius Giurca, S., Juhan, V., Caramella, T., Perrey, A., Desmots, F., Faivre-Pierre, M., Abitbol, M., Lotte, R., Istrati, D., Guenoun, D., Luciani, A., Zins, M., Meder, J.-F., and Cotten, A.

Published
2019
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3. Development of ClearPEM-Sonic, a multimodal mammography system for PET and Ultrasound

Author

Cucciati, G, Auffray, E, Bugalho, R, Cao, L, Vara, N, Farina, F, Felix, N, Frisch, B, Ghezzi, A, Juhan, V, Jun, D, Lasaygues, P, Lecoq, P, Mensah, S, Mundler, O, Neves, J, Paganoni, M, Peter, J, Pizzichemi, M, Siles, P, Silva, J, Silva, R, Tavernier, S, Tessonnier, L, Varela, J, CUCCIATI, GIACOMO, FARINA, FABIO MARIO, GHEZZI, ALESSIO, PAGANONI, MARCO, PIZZICHEMI, MARCO, Varela, J., Cucciati, G, Auffray, E, Bugalho, R, Cao, L, Vara, N, Farina, F, Felix, N, Frisch, B, Ghezzi, A, Juhan, V, Jun, D, Lasaygues, P, Lecoq, P, Mensah, S, Mundler, O, Neves, J, Paganoni, M, Peter, J, Pizzichemi, M, Siles, P, Silva, J, Silva, R, Tavernier, S, Tessonnier, L, Varela, J, CUCCIATI, GIACOMO, FARINA, FABIO MARIO, GHEZZI, ALESSIO, PAGANONI, MARCO, PIZZICHEMI, MARCO, and Varela, J.

Abstract

ClearPEM-Sonic is an innovative imaging device specifically developed for breast cancer. The possibility to work in PEM-Ultrasound multimodality allows to obtain metabolic and morphological information increasing the specificity of the exam. The ClearPEM detector is developed to maximize the sensitivity and the spatial resolution as compared to Whole-Body PET scanners. It is coupled with a 3D ultrasound system, the SuperSonic Imagine Aixplorer that improves the specificity of the exam by providing a tissue elasticity map. This work describes the ClearPEM-Sonic project focusing on the technological developments it has required, the technical merits (and limits) and the first multimodal images acquired on a dedicated phantom. It finally presents selected clinical case studies that confirm the value of PEM information. © CERN 2014.

Published
2014

4. Breast Cancer Diagnosis: First Clinical Results with ClearPEM-Sonic, the Multimodal Positron Emission Mammograph and Ultrasound Scanner

Author

Tessonnier, L, Siles, P, Frisch, B, Rodriguez, F, Pizzichemi, M, Felix, N, Bughalo, R, Varela, J, Juhan, V, Lecoq, P, Mundler, O, PIZZICHEMI, MARCO, Mundler, O., Tessonnier, L, Siles, P, Frisch, B, Rodriguez, F, Pizzichemi, M, Felix, N, Bughalo, R, Varela, J, Juhan, V, Lecoq, P, Mundler, O, PIZZICHEMI, MARCO, and Mundler, O.

Abstract

Introduction: Breast cancer is the most frequent cancer amongst women. X‐ray mammography and ultrasound (US) exam are used for screening and routine diagnosis. However, breast cancer diagnosis can be difficult in patients with dense breasts, breast implants or prior surgery. Breast MRI is the most sensitive modality, h owever, its low specificity could lead to unnecessary biopsies. A new nuclear medical technique dedicated to breast imaging emerged, positron emission mammography (PEM). Goals: We therefore design a multimodal system that provides co‐registered metabolic, anatomical and structural information: ClearPEM‐Sonic . It combines the ClearPEM, a high‐resolution PEM developed by the Crystal Clear Collaboration, with the SuperSonic Aixplorer, a 3D ultrasound (US) and elastography system. ClearPEM‐Sonic is installed at Hopital Nord, Marseille, FR, and coordinated by CERIMED, the European Center for Research in Medical Imaging . Methods and Materials: ClearPEM  ‐  ClearPEM is a positron emission tomograph dedicated to mammography, based on LYSO:Ce crystals grouped into two planar detector plates of 16.2 x 14.1 cm2, allowing measurement of the depth of interaction . SuperSonic Imagine Aixplorer The SuperSonic Imagine Aixplorer ultrasound system combines classic B‐mode ultrasound with shearwave elastography The probe used in ClearPEM‐Sonic acquires a 3D B‐mode and elastography volume. Multimodality: A position tracking system records the exact location and inclination of the US transducer and allows image co‐registration with PEM. Phantoms: We used Ultra Micro Hotspot Phantom to obtain ClearPEM image resolution. We made breast fantoms by means of gelatin and Agar mimicking breast tissue and cancerous lesions that can be visualized by US and PEM. Clinical evaluation: We report preliminary results about an ongoing phase one clinical trial with patients who have a proven breast cancer and were injected with 18F‐ Fluorodeoxyglucose for a whole‐body PET/CT exa

Published
2012

6. Development of ClearPEM-Sonic, a multimodal mammography system for PET and Ultrasound

Author

O. Mundler, D. Jun, Joao Varela, N. Di Vara, P. Siles, Benjamin Frisch, V. Juhan, G. Cucciati, Paul Lecoq, M. Pizzichemi, N. Felix, Jorge A. Neves, Philippe Lasaygues, F Farina, J. Peter, l. Tessonnier, S. Tavernier, Serge Mensah, João Carlos Silva, Etiennette Auffray, M. Paganoni, R. Bugalho, Rui F. Silva, A Ghezzi, Liji Cao, Physics, Elementary Particle Physics, Ondes et Imagerie (O&I), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Cucciati, G, Auffray, E, Bugalho, R, Cao, L, Vara, N, Farina, F, Felix, N, Frisch, B, Ghezzi, A, Juhan, V, Jun, D, Lasaygues, P, Lecoq, P, Mensah, S, Mundler, O, Neves, J, Paganoni, M, Peter, J, Pizzichemi, M, Siles, P, Silva, J, Silva, R, Tavernier, S, Tessonnier, L, and Varela, J

Subjects
medicine.medical_specialty, Computer science, PET PET/CT, Imaging phantom, law.invention, law, Tissue elasticity, Multimodality systems, medicine, Mammography, 3D ultrasound, Medical physics, Multimodality system, Image resolution, Instrumentation, Gamma camera, coronary CT angiography (CTA), Mathematical Physics, medicine.diagnostic_test, business.industry, Ultrasound, Detector, 3. Good health, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], SPECT, business
Abstract

International audience; ClearPEM-Sonic is an innovative imaging device specifically developed for breast cancer. The possibility to work in PEM-Ultrasound multimodality allows to obtain metabolic and morphological information increasing the specificity of the exam. The ClearPEM detector is developed to maximize the sensitivity and the spatial resolution as compared to Whole-Body PET scanners. It is coupled with a 3D ultrasound system, the SuperSonic Imagine Aixplorer that improves the specificity of the exam by providing a tissue elasticity map. This work describes the ClearPEM-Sonic project focusing on the technological developments it has required, the technical merits (and limits) and the first multimodal images acquired on a dedicated phantom. It finally presents selected clinical case studies that confirm the value of PEM information.

7. Ovarian-Adnexal Reporting Data System Magnetic Resonance Imaging (O-RADS MRI) Score for Risk Stratification of Sonographically Indeterminate Adnexal Masses.

Author

Thomassin-Naggara I, Poncelet E, Jalaguier-Coudray A, Guerra A, Fournier LS, Stojanovic S, Millet I, Bharwani N, Juhan V, Cunha TM, Masselli G, Balleyguier C, Malhaire C, Perrot NF, Sadowski EA, Bazot M, Taourel P, Porcher R, Darai E, Reinhold C, and Rockall AG

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Middle Aged, Risk Assessment, Sensitivity and Specificity, Young Adult, False Negative Reactions, False Positive Reactions, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging standards, Ovarian Diseases diagnosis, Ultrasonography methods, Ultrasonography standards
Abstract

Importance: Approximately one-quarter of adnexal masses detected at ultrasonography are indeterminate for benignity or malignancy, posing a substantial clinical dilemma., Objective: To validate the accuracy of a 5-point Ovarian-Adnexal Reporting Data System Magnetic Resonance Imaging (O-RADS MRI) score for risk stratification of adnexal masses., Design, Setting, and Participants: This multicenter cohort study was conducted between March 1, 2013, and March 31, 2016. Among patients undergoing expectant management, 2-year follow-up data were completed by March 31, 2018. A routine pelvic MRI was performed among consecutive patients referred to characterize a sonographically indeterminate adnexal mass according to routine diagnostic practice at 15 referral centers. The MRI score was prospectively applied by 2 onsite readers and by 1 reader masked to clinical and ultrasonographic data. Data analysis was conducted between April and November 2018., Main Outcomes and Measures: The primary end point was the joint analysis of true-negative and false-negative rates according to the MRI score compared with the reference standard (ie, histology or 2-year follow-up)., Results: A total of 1340 women (mean [range] age, 49 [18-96] years) were enrolled. Of 1194 evaluable women, 1130 (94.6%) had a pelvic mass on MRI with a reference standard (surgery, 768 [67.9%]; 2-year follow-up, 362 [32.1%]). A total of 203 patients (18.0%) had at least 1 malignant adnexal or nonadnexal pelvic mass. No invasive cancer was assigned a score of 2. Positive likelihood ratios were 0.01 for score 2, 0.27 for score 3, 4.42 for score 4, and 38.81 for score 5. Area under the receiver operating characteristic curve was 0.961 (95% CI, 0.948-0.971) among experienced readers, with a sensitivity of 0.93 (95% CI, 0.89-0.96; 189 of 203 patients) and a specificity of 0.91 (95% CI, 0.89-0.93; 848 of 927 patients). There was good interrater agreement among both experienced and junior readers (κ = 0.784; 95% CI, 0.743-0824). Of 580 of 1130 women (51.3%) with a mass on MRI and no specific gynecological symptoms, 362 (62.4%) underwent surgery. Of them, 244 (67.4%) had benign lesions and a score of 3 or less. The MRI score correctly reclassified the mass origin as nonadnexal with a sensitivity of 0.99 (95% CI, 0.98-0.99; 1360 of 1372 patients) and a specificity of 0.78 (95% CI, 0.71-0.85; 102 of 130 patients)., Conclusions and Relevance: In this study, the O-RADS MRI score was accurate when stratifying the risk of malignancy in adnexal masses.

Published
2020
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